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-rw-r--r--R/nlmixr.R30
1 files changed, 29 insertions, 1 deletions
diff --git a/R/nlmixr.R b/R/nlmixr.R
index fd12f555..e41777ac 100644
--- a/R/nlmixr.R
+++ b/R/nlmixr.R
@@ -157,6 +157,30 @@ nlmixr::nlmixr
#' plot(f_nlmixr_fomc_sfo_focei_obs_tc)
#' summary(f_nlmixr_fomc_sfo_focei_obs_tc)
#' }
+#'
+#' # Two parallel metabolites
+#' dmta_ds <- lapply(1:7, function(i) {
+#' ds_i <- dimethenamid_2018$ds[[i]]$data
+#' ds_i[ds_i$name == "DMTAP", "name"] <- "DMTA"
+#' ds_i$time <- ds_i$time * dimethenamid_2018$f_time_norm[i]
+#' ds_i
+#' })
+#' names(dmta_ds) <- sapply(dimethenamid_2018$ds, function(ds) ds$title)
+#' dmta_ds[["Elliot"]] <- rbind(dmta_ds[["Elliot 1"]], dmta_ds[["Elliot 2"]])
+#' dmta_ds[["Elliot 1"]] <- NULL
+#' dmta_ds[["Elliot 2"]] <- NULL
+#' sfo_sfo2 <- mkinmod(
+#' DMTA = mkinsub("SFO", c("M23", "M27")),
+#' M23 = mkinsub("SFO"),
+#' M27 = mkinsub("SFO"),
+#' quiet = TRUE
+#' )
+#' f_dmta_sfo_sfo2 <- mmkin(
+#' list("SFO-SFO2" = sfo_sfo2),
+#' dmta_ds, quiet = TRUE, error_model = "obs")
+#' nlmixr_model(f_dmta_sfo_sfo2)
+#' nlmixr_focei_dmta_sfo_sfo2 <- nlmixr(f_dmta_sfo_sfo2, est = "focei")
+#'
#' @export
nlmixr.mmkin <- function(object, data = NULL,
est = NULL, control = list(),
@@ -452,11 +476,15 @@ nlmixr_model <- function(object,
# Population initial values for logit transformed parameters
for (parm_name in grep("_qlogis$", names(degparms_start), value = TRUE)) {
- parm_name_new <- names(
+ if (grepl("_tffm0_", parm_name)) {
+ parm_name_new <- gsub("_qlogis$", "", parm_name)
+ } else {
+ parm_name_new <- names(
backtransform_odeparms(degparms_start[parm_name],
object[[1]]$mkinmod,
object[[1]]$transform_rates,
object[[1]]$transform_fractions))
+ }
model_block <- paste0(
model_block,
parm_name_new, " = ",

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