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1 files changed, 119 insertions, 185 deletions
diff --git a/docs/reference/mixed.html b/docs/reference/mixed.html
index b3bf35bf..dc0d1681 100644
--- a/docs/reference/mixed.html
+++ b/docs/reference/mixed.html
@@ -1,67 +1,12 @@
-<!-- Generated by pkgdown: do not edit by hand -->
<!DOCTYPE html>
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+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Create a mixed effects model from an mmkin row object — mixed • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Create a mixed effects model from an mmkin row object — mixed"><meta property="og:description" content="Create a mixed effects model from an mmkin row object"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-<![endif]-->
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+<![endif]--></head><body data-spy="scroll" data-target="#toc">
+
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-
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+ <header><div class="navbar navbar-default navbar-fixed-top" role="navigation">
<div class="container">
<div class="navbar-header">
<button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false">
@@ -72,13 +17,12 @@
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<span class="navbar-brand">
<a class="navbar-link" href="../index.html">mkin</a>
- <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span>
+ <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span>
</span>
</div>
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- <ul class="nav navbar-nav">
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+ <ul class="nav navbar-nav"><li>
<a href="../reference/index.html">Functions and data</a>
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<li class="dropdown">
@@ -87,8 +31,7 @@
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- <ul class="dropdown-menu" role="menu">
- <li>
+ <ul class="dropdown-menu" role="menu"><li>
<a href="../articles/mkin.html">Introduction to mkin</a>
</li>
<li>
@@ -98,6 +41,9 @@
<a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a>
</li>
<li>
+ <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+ </li>
+ <li>
<a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
</li>
<li>
@@ -112,34 +58,27 @@
<li>
<a href="../articles/web_only/benchmarks.html">Some benchmark timings</a>
</li>
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+ </ul></li>
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- <a href="https://github.com/jranke/mkin/">
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+ <a href="https://github.com/jranke/mkin/" class="external-link">
<span class="fab fa-github fa-lg"></span>
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+ </ul></div><!--/.nav-collapse -->
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+ </header><div class="row">
<div class="col-md-9 contents">
<div class="page-header">
<h1>Create a mixed effects model from an mmkin row object</h1>
- <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mixed.mmkin.R'><code>R/mixed.mmkin.R</code></a></small>
+ <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mixed.mmkin.R" class="external-link"><code>R/mixed.mmkin.R</code></a></small>
<div class="hidden name"><code>mixed.Rd</code></div>
</div>
@@ -147,131 +86,126 @@
<p>Create a mixed effects model from an mmkin row object</p>
</div>
- <pre class="usage"><span class='fu'>mixed</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span>
-
-<span class='co'># S3 method for mmkin</span>
-<span class='fu'>mixed</span><span class='op'>(</span><span class='va'>object</span>, method <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"none"</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span>
-
-<span class='co'># S3 method for mixed.mmkin</span>
-<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span></pre>
+ <div id="ref-usage">
+ <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span>
- <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
- <table class="ref-arguments">
- <colgroup><col class="name" /><col class="desc" /></colgroup>
- <tr>
- <th>object</th>
- <td><p>An <a href='mmkin.html'>mmkin</a> row object</p></td>
- </tr>
- <tr>
- <th>...</th>
- <td><p>Currently not used</p></td>
- </tr>
- <tr>
- <th>method</th>
- <td><p>The method to be used</p></td>
- </tr>
- <tr>
- <th>x</th>
- <td><p>A mixed.mmkin object to print</p></td>
- </tr>
- <tr>
- <th>digits</th>
- <td><p>Number of digits to use for printing.</p></td>
- </tr>
- </table>
+<span class="co"># S3 method for mmkin</span>
+<span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"none"</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span>
+<span class="co"># S3 method for mixed.mmkin</span>
+<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></code></pre></div>
+ </div>
- <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
- <pre class="examples"><div class='input'><span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span>
-<span class='va'>n_biphasic</span> <span class='op'>&lt;-</span> <span class='fl'>8</span>
-<span class='va'>err_1</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>const <span class='op'>=</span> <span class='fl'>1</span>, prop <span class='op'>=</span> <span class='fl'>0.07</span><span class='op'>)</span>
-
-<span class='va'>DFOP_SFO</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>
- parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='st'>"m1"</span><span class='op'>)</span>,
- m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>,
- quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-
-<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>123456</span><span class='op'>)</span>
-<span class='va'>log_sd</span> <span class='op'>&lt;-</span> <span class='fl'>0.3</span>
-<span class='va'>syn_biphasic_parms</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/matrix.html'>as.matrix</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span>
- k1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.05</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span>,
- k2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.01</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span>,
- g <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Logistic.html'>plogis</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/stats/Normal.html'>rnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fl'>0</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span>,
- f_parent_to_m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Logistic.html'>plogis</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/stats/Normal.html'>rnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fl'>0</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span>,
- k_m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.002</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span>
-
-<span class='va'>ds_biphasic_mean</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='fl'>1</span><span class='op'>:</span><span class='va'>n_biphasic</span>,
- <span class='kw'>function</span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'>{</span>
- <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>DFOP_SFO</span>, <span class='va'>syn_biphasic_parms</span><span class='op'>[</span><span class='va'>i</span>, <span class='op'>]</span>,
- <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='va'>sampling_times</span><span class='op'>)</span>
- <span class='op'>}</span>
-<span class='op'>)</span>
-
-<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>123456L</span><span class='op'>)</span>
-<span class='va'>ds_biphasic</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>ds_biphasic_mean</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'>{</span>
- <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>ds</span>,
- sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>sqrt</a></span><span class='op'>(</span><span class='va'>err_1</span><span class='op'>$</span><span class='va'>const</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>+</span> <span class='va'>value</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>*</span> <span class='va'>err_1</span><span class='op'>$</span><span class='va'>prop</span><span class='op'>^</span><span class='fl'>2</span><span class='op'>)</span>,
- n <span class='op'>=</span> <span class='fl'>1</span>, secondary <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span>
-<span class='op'>}</span><span class='op'>)</span>
-
-<span class='co'># \dontrun{</span>
-<span class='va'>f_mmkin</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"DFOP-SFO"</span> <span class='op'>=</span> <span class='va'>DFOP_SFO</span><span class='op'>)</span>, <span class='va'>ds_biphasic</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
+ <div id="arguments">
+ <h2>Arguments</h2>
+ <dl><dt>object</dt>
+<dd><p>An <a href="mmkin.html">mmkin</a> row object</p></dd>
+<dt>...</dt>
+<dd><p>Currently not used</p></dd>
+<dt>method</dt>
+<dd><p>The method to be used</p></dd>
+<dt>x</dt>
+<dd><p>A mixed.mmkin object to print</p></dd>
+<dt>digits</dt>
+<dd><p>Number of digits to use for printing.</p></dd>
+</dl></div>
+ <div id="value">
+ <h2>Value</h2>
+ <p>An object of class 'mixed.mmkin' which has the observed data in a
+single dataframe which is convenient for plotting</p>
+ </div>
-<span class='va'>f_mixed</span> <span class='op'>&lt;-</span> <span class='fu'>mixed</span><span class='op'>(</span><span class='va'>f_mmkin</span><span class='op'>)</span>
-<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f_mixed</span><span class='op'>)</span>
-</div><div class='output co'>#&gt; Kinetic model fitted by nonlinear regression to each dataset
-#&gt; Structural model:
-#&gt; d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
-#&gt; time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
-#&gt; * parent
-#&gt; d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
-#&gt; * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
-#&gt; exp(-k2 * time))) * parent - k_m1 * m1
-#&gt;
-#&gt; Data:
-#&gt; 271 observations of 2 variable(s) grouped in 8 datasets
-#&gt;
-#&gt; &lt;mmkin&gt; object
-#&gt; Status of individual fits:
-#&gt;
-#&gt; dataset
-#&gt; model 1 2 3 4 5 6 7 8
-#&gt; DFOP-SFO OK OK OK OK OK OK OK OK
-#&gt;
-#&gt; OK: No warnings
-#&gt;
-#&gt; Mean fitted parameters:
-#&gt; parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2
-#&gt; 100.674757 -8.761916 -0.004347 -3.348812 -3.986853
-#&gt; g_qlogis
-#&gt; -0.087392 </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_mixed</span><span class='op'>)</span>
-</div><div class='img'><img src='mixed-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span>
-</div></pre>
+ <div id="ref-examples">
+ <h2>Examples</h2>
+ <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span>
+<span class="r-in"><span class="va">n_biphasic</span> <span class="op">&lt;-</span> <span class="fl">8</span></span>
+<span class="r-in"><span class="va">err_1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>const <span class="op">=</span> <span class="fl">1</span>, prop <span class="op">=</span> <span class="fl">0.07</span><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="va">DFOP_SFO</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span>
+<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span>
+<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span>
+<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456</span><span class="op">)</span></span>
+<span class="r-in"><span class="va">log_sd</span> <span class="op">&lt;-</span> <span class="fl">0.3</span></span>
+<span class="r-in"><span class="va">syn_biphasic_parms</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">as.matrix</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span>
+<span class="r-in"> k1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.05</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span>
+<span class="r-in"> k2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.01</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span>
+<span class="r-in"> g <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span>
+<span class="r-in"> f_parent_to_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span>
+<span class="r-in"> k_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.002</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="va">ds_biphasic_mean</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="va">n_biphasic</span>,</span>
+<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span>
+<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">syn_biphasic_parms</span><span class="op">[</span><span class="va">i</span>, <span class="op">]</span>,</span>
+<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span>
+<span class="r-in"> <span class="op">}</span></span>
+<span class="r-in"><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456L</span><span class="op">)</span></span>
+<span class="r-in"><span class="va">ds_biphasic</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_biphasic_mean</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span>
+<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span>
+<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="va">err_1</span><span class="op">$</span><span class="va">const</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="va">err_1</span><span class="op">$</span><span class="va">prop</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span>
+<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span>, secondary <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span>
+<span class="r-in"><span class="op">}</span><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="co"># \dontrun{</span></span>
+<span class="r-in"><span class="va">f_mmkin</span> <span class="op">&lt;-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="va">ds_biphasic</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span>
+<span class="r-in"></span>
+<span class="r-in"><span class="va">f_mixed</span> <span class="op">&lt;-</span> <span class="fu">mixed</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span>
+<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Kinetic model fitted by nonlinear regression to each dataset</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Structural model:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> * parent</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> exp(-k2 * time))) * parent - k_m1 * m1</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Data:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 271 observations of 2 variable(s) grouped in 8 datasets</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> &lt;mmkin&gt; object</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Status of individual fits:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> dataset</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> model 1 2 3 4 5 6 7 8 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> DFOP-SFO OK OK OK OK OK OK OK OK</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> OK: No warnings</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Mean fitted parameters:</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 100.674757 -8.761916 -0.004347 -3.348812 -3.986853 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> -0.087392 </span>
+<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span>
+<span class="r-plt img"><img src="mixed-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span class="co"># }</span></span>
+</code></pre></div>
+ </div>
</div>
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