Dose-Response data for 1-methyl-3-alkylimidazolium tetrafluoroborates in IPC-81 cells

This is the raw data documenting the influence of the alkyl chain length in 3 position on the toxicity to the promyelocytic leukemia rat cell line IPC-81. The substances are named according to the UFT naming scheme of these substances. IM13 BF4 means 1-methyl-3-propylimidazolium tetrafluoroborate, IM14 BF4 means 1-methyl-3-butylimidazolium tetrafluoroborate and IM1-10 BF4 means 1-methyl-3-decylimidazolium tetrafluoroborate. This is a subset (only the BF4 anion) of the data shown in Figure 3 in Ranke et al. (2004).

data(IM1xIPC81)

Format

A dataframe containing the data as required for the drfit function. An additional column contains the tested organism (name of the cell line).

Source

Ranke J, Mölter K, Stock F, Bottin-Weber U, Poczobutt J, Hoffmann J, Ondruschka B, Filser J, Jastorff B (2004) Biological effects of imidazolium ionic liquids with varying chain lenghts in acute Vibrio fischeri and WST-1 cell viability assays. Ecotoxicology and Environmental Safety 58(3) 396-404

Examples

  rIM1xIPC81 <- drfit(IM1xIPC81, linlogit = TRUE, showED50 = TRUE, EDx = 10)
#> 
#> IM13 BF4: Fitting data...
#> 
#> IM14 BF4: Fitting data...
#> Warning: NaNs wurden erzeugt
#> 
#> IM15 BF4: Fitting data...
#> 
#> IM16 BF4: Fitting data...
#> 
#> IM17 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs wurden erzeugt
#> 
#> IM18 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs wurden erzeugt
#> 
#> IM19 BF4: Fitting data...
#> Waiting for profiling to be done...
#> Warning: NaNs wurden erzeugt
#> 
#> IM1-10 BF4: Fitting data...
#> Waiting for profiling to be done...

  rIM1xIPC81.drc <- drcfit(IM1xIPC81, linlogit = TRUE, showED50 = TRUE, EDx = 10)
#> 
#> IM13 BF4: Fitting data...
#> 
#> IM14 BF4: Fitting data...
#> 
#> IM15 BF4: Fitting data...
#> 
#> IM16 BF4: Fitting data...
#> 
#> IM17 BF4: Fitting data...
#> 
#> IM18 BF4: Fitting data...
#> 
#> IM19 BF4: Fitting data...
#> 
#> IM1-10 BF4: Fitting data...

  print(rIM1xIPC81,digits=4)
#>    Substance ndl   n     lld   lhd    mtype logED50  2.5%  97.5%   unit  sigma
#> 1   IM13 BF4   9  81  0.5918 3.000 inactive      NA    NA     NA microM     NA
#> 2   IM14 BF4  20 216 -0.0103 3.176   no fit      NA    NA     NA microM     NA
#> 3   IM15 BF4   9 135  0.5918 3.000 inactive      NA    NA     NA microM     NA
#> 4   IM16 BF4   9 108  0.5918 3.000 inactive      NA    NA     NA microM     NA
#> 5   IM17 BF4   9  81  0.5918 3.000 linlogit  2.5786 2.506 2.6617 microM 0.2376
#> 6   IM18 BF4   9 135  0.5918 3.000 linlogit  1.6806 1.623 1.7419 microM 0.2325
#> 7   IM19 BF4   9  81  0.5918 3.000 linlogit  1.6496 1.598 1.7031 microM 0.1453
#> 8 IM1-10 BF4  11 162 -0.0103 3.000 linlogit  0.7697 0.687 0.8544 microM 0.2988
#>        a     b       c    ED50 ED50 2.5% ED50 97.5%   EDx10
#> 1     NA    NA      NA      NA        NA         NA      NA
#> 2     NA    NA      NA      NA        NA         NA      NA
#> 3     NA    NA      NA      NA        NA         NA      NA
#> 4     NA    NA      NA      NA        NA         NA      NA
#> 5 2.5786 2.300 0.01468 378.941   320.424    458.918 230.782
#> 6 1.6806 2.237 0.05719  47.930    41.973     55.194  27.367
#> 7 1.6496 1.977 0.10956  44.628    39.671     50.483  23.031
#> 8 0.7697 1.936 0.45809   5.884     4.864      7.152   2.835
  print(rIM1xIPC81.drc,digits=4)
#>    Substance ndl   n     lld   lhd    mtype logED50   2.5%  97.5%   unit  sigma
#> 1   IM13 BF4   9  81  0.5918 3.000 inactive      NA     NA     NA microM     NA
#> 2   IM14 BF4  20 216 -0.0103 3.176 linlogit      NA     NA     NA microM 0.1529
#> 3   IM15 BF4   9 135  0.5918 3.000 inactive      NA     NA     NA microM     NA
#> 4   IM16 BF4   9 108  0.5918 3.000 inactive      NA     NA     NA microM     NA
#> 5   IM17 BF4   9  81  0.5918 3.000 linlogit  2.5786 2.4935 2.6497 microM 0.2376
#> 6   IM18 BF4   9 135  0.5918 3.000 linlogit  1.6806 1.6168 1.7362 microM 0.2325
#> 7   IM19 BF4   9  81  0.5918 3.000 linlogit  1.6496 1.5940 1.6990 microM 0.1453
#> 8 IM1-10 BF4  11 162 -0.0103 3.000 linlogit  0.7697 0.6774 0.8458 microM 0.2988
#>           a      b          c    ED50 ED50 2.5% ED50 97.5%   EDx10 EDx10 2.5%
#> 1        NA     NA         NA      NA        NA         NA      NA         NA
#> 2 5.390e+15 0.3148 -0.0001736      NA        NA         NA      NA         NA
#> 3        NA     NA         NA      NA        NA         NA      NA         NA
#> 4        NA     NA         NA      NA        NA         NA      NA         NA
#> 5 1.281e+02 2.3001  0.0146821 378.964   311.555    446.372 230.790    202.915
#> 6 2.079e+01 2.2373  0.0571925  47.930    41.382     54.478  27.367     23.809
#> 7 1.342e+01 1.9773  0.1094542  44.630    39.260     50.000  23.036     20.614
#> 8 2.258e+00 1.9362  0.4580784   5.884     4.758      7.011   2.835      2.181
#>   EDx10 97.5%
#> 1          NA
#> 2          NA
#> 3          NA
#> 4          NA
#> 5     258.665
#> 6      30.925
#> 7      25.459
#> 8       3.489