R : Copyright 2006, The R Foundation for Statistical Computing Version 2.3.0 (2006-04-24) ISBN 3-900051-07-0 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(drfit) Loading required package: MASS Loading required package: RODBC > data(IM1xIPC81) > rIM1xIPC81 <- drfit(IM1xIPC81,linlogit=TRUE) IM13 BF4: Fitting data... IM14 BF4: Fitting data... Error in nls(response ~ linlogitf(dose, 1, f, logED50, b), data = tmp, : singular gradient Error in numericDeriv(form[[3]], names(ind), env) : Missing value or an infinity produced when evaluating the model In addition: Warning message: NaNs produced in: pnorm(q, mean, sd, lower.tail, log.p) IM15 BF4: Fitting data... IM16 BF4: Fitting data... IM17 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env) : Missing value or an infinity produced when evaluating the model In addition: Warning message: NaNs produced in: pnorm(q, mean, sd, lower.tail, log.p) IM18 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env) : Missing value or an infinity produced when evaluating the model In addition: Warning message: NaNs produced in: pnorm(q, mean, sd, lower.tail, log.p) IM19 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env) : Missing value or an infinity produced when evaluating the model In addition: Warning message: NaNs produced in: pnorm(q, mean, sd, lower.tail, log.p) IM1-10 BF4: Fitting data... Waiting for profiling to be done... > rIM1xIPC81 Substance ndl n lld lhd mtype logED50 2.5% 1 IM13 BF4 9 81 0.59176003 3.000000 inactive NA NA 2 IM14 BF4 20 216 -0.01030017 3.176091 no fit NA NA 3 IM15 BF4 9 135 0.59176003 3.000000 inactive NA NA 4 IM16 BF4 9 108 0.59176003 3.000000 inactive NA NA 5 IM17 BF4 9 81 0.59176003 3.000000 linlogit 2.5785719 2.5057219 6 IM18 BF4 9 135 0.59176003 3.000000 linlogit 1.6806040 1.6229756 7 IM19 BF4 9 81 0.59176003 3.000000 linlogit 1.6496121 1.5984793 8 IM1-10 BF4 11 162 -0.01030017 3.000000 linlogit 0.7696961 0.6870081 97.5% unit sigma a b c 1 NA 然 NA NA NA NA 2 NA 然 NA NA NA NA 3 NA 然 NA NA NA NA 4 NA 然 NA NA NA NA 5 2.6617385 然 0.2375857 2.5785719 2.300216 0.01468034 6 1.7418917 然 0.2324871 1.6806040 2.237338 0.05719295 7 1.7031463 然 0.1452716 1.6496121 1.976976 0.10956088 8 0.8544213 然 0.2987708 0.7696961 1.936253 0.45808611 >