R version 2.6.0 RC (2007-09-25 r42980) Copyright (C) 2007 The R Foundation for Statistical Computing ISBN 3-900051-07-0 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for an HTML browser interface to help. Type 'q()' to quit R. > library(drfit) Loading required package: MASS Loading required package: RODBC > data(IM1xIPC81) > rIM1xIPC81 <- drfit(IM1xIPC81,linlogit=TRUE) IM13 BF4: Fitting data... IM14 BF4: Fitting data... Error in nls(response ~ linlogitf(dose, 1, f, logED50, b), data = tmp, : Convergence failure: false convergence (8) Error in numericDeriv(form[[3]], names(ind), env, ifelse(internalPars < : Missing value or an infinity produced when evaluating the model In addition: Warning message: In pnorm(q, mean, sd, lower.tail, log.p) : NaNs produced IM15 BF4: Fitting data... IM16 BF4: Fitting data... IM17 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env, ifelse(internalPars < : Missing value or an infinity produced when evaluating the model In addition: Warning message: In pnorm(q, mean, sd, lower.tail, log.p) : NaNs produced IM18 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env, ifelse(internalPars < : Missing value or an infinity produced when evaluating the model In addition: Warning message: In pnorm(q, mean, sd, lower.tail, log.p) : NaNs produced IM19 BF4: Fitting data... Waiting for profiling to be done... Error in numericDeriv(form[[3]], names(ind), env, ifelse(internalPars < : Missing value or an infinity produced when evaluating the model In addition: Warning message: In pnorm(q, mean, sd, lower.tail, log.p) : NaNs produced IM1-10 BF4: Fitting data... Waiting for profiling to be done... > print(rIM1xIPC81,digits=5) Substance ndl n lld lhd mtype logED50 2.5% 97.5% unit 1 IM13 BF4 9 81 0.591760 3.0000 inactive NA NA NA microM 2 IM14 BF4 20 216 -0.010300 3.1761 no fit NA NA NA microM 3 IM15 BF4 9 135 0.591760 3.0000 inactive NA NA NA microM 4 IM16 BF4 9 108 0.591760 3.0000 inactive NA NA NA microM 5 IM17 BF4 9 81 0.591760 3.0000 linlogit 2.5786 2.50572 2.66174 microM 6 IM18 BF4 9 135 0.591760 3.0000 linlogit 1.6806 1.62298 1.74189 microM 7 IM19 BF4 9 81 0.591760 3.0000 linlogit 1.6496 1.59848 1.70315 microM 8 IM1-10 BF4 11 162 -0.010300 3.0000 linlogit 0.7697 0.68701 0.85442 microM sigma a b c 1 NA NA NA NA 2 NA NA NA NA 3 NA NA NA NA 4 NA NA NA NA 5 0.23759 2.5786 2.3002 0.014680 6 0.23249 1.6806 2.2373 0.057193 7 0.14527 1.6496 1.9770 0.109561 8 0.29877 0.7697 1.9363 0.458090 >