From 1718d434efae26de02754c6622c43f4dc9e624b9 Mon Sep 17 00:00:00 2001 From: jranke Date: Thu, 15 Mar 2012 15:54:14 +0000 Subject: Update kinfit and mkin to the latest version published on BerliOS. git-svn-id: svn+ssh://svn.r-forge.r-project.org/svnroot/kinfit/pkg/mkin@17 edb9625f-4e0d-4859-8d74-9fd3b1da38cb --- inst/GUI/.RData | Bin 0 -> 17960 bytes inst/GUI/.Rhistory | 3 + inst/GUI/gdf-test.R | 12 + inst/GUI/simple-Gtk.R | 33 + inst/GUI/simple.R | 68 + inst/GUI/test.R | 17 + inst/doc/Rplots.pdf | 23902 +++++++++++++++++++++++++++++++++++++++ inst/doc/mkin.Rnw | 25 +- inst/doc/mkin.pdf | Bin 176018 -> 178902 bytes inst/doc/references.bib | 7 + inst/unitTests/runit.mkinfit.R | 28 +- inst/unitTests/runit.mkinmod.R | 61 +- 12 files changed, 24140 insertions(+), 16 deletions(-) create mode 100644 inst/GUI/.RData create mode 100644 inst/GUI/.Rhistory create mode 100644 inst/GUI/gdf-test.R create mode 100644 inst/GUI/simple-Gtk.R create mode 100644 inst/GUI/simple.R create mode 100644 inst/GUI/test.R create mode 100644 inst/doc/Rplots.pdf (limited to 'inst') diff --git a/inst/GUI/.RData b/inst/GUI/.RData new file mode 100644 index 0000000..2e82ef7 Binary files /dev/null and b/inst/GUI/.RData differ diff --git a/inst/GUI/.Rhistory b/inst/GUI/.Rhistory new file mode 100644 index 0000000..0704745 --- /dev/null +++ b/inst/GUI/.Rhistory @@ -0,0 +1,3 @@ +require(gWidgetsWWW) +localServerStart("simple.R") +quit("yes") diff --git a/inst/GUI/gdf-test.R b/inst/GUI/gdf-test.R new file mode 100644 index 0000000..b1ec20a --- /dev/null +++ b/inst/GUI/gdf-test.R @@ -0,0 +1,12 @@ +w <- gwindow("gdf test") +g <- ggroup(horizontal=FALSE, cont=w) +d <- gdf(data.frame(a=c(1.1, 2.2, 3.3), b= c("one", "two", "three"), stringsAsFactors=FALSE), + name = "Test for editing character columns", cont=g) +size(d) <- c(400,400) +gbutton("Change [1,2]", handler=function(h,...) { + d[1,2] <- "test" +}, container=g) +gbutton("Value of [1,2]", handler=function(h,...) { + galert(d[1,2], parent=d) +}, cont=g) +visible(w) <- TRUE diff --git a/inst/GUI/simple-Gtk.R b/inst/GUI/simple-Gtk.R new file mode 100644 index 0000000..8affdcc --- /dev/null +++ b/inst/GUI/simple-Gtk.R @@ -0,0 +1,33 @@ +# Work in progress - simple Gtk2 GUI for mkin +require(gWidgets) +options("guiToolkit"="RGtk2") + +w <- gwindow("Simple R GUI for kinetic evaluations", + width=800, height=500) + +# Project definition expanding group +pr <- gexpandgroup("Project definition", container=w) + +n.observed <- 1 +max.n.observed <- 9 +observed.names = c("parent", paste("M", 1:(max.n.observed - 1), sep="")) + +prg <- ggroup(horizontal=FALSE, cont = w) +prl <- glayout(cont = prg) +prl[1,1] <- glabel("Number of observed variables", cont=prl) +prl[1,2] <- (n.observed.gw = gcombobox( + 1:max.n.observed, + handler = function(h, ...) { + n.observed <- svalue(n.observed.gw) + visible(observed.gw) <- c( + rep(TRUE, svalue(n.observed)), + rep(FALSE, max.n.observed - n.observed)) + }, + cont=prl)) + +observed.gw <- gdf( + items = data.frame(Index = 1:max.n.observed, + Name = observed.names, stringsAsFactors=FALSE), + name = "Names of observed variables", + cont=prg) + diff --git a/inst/GUI/simple.R b/inst/GUI/simple.R new file mode 100644 index 0000000..c187414 --- /dev/null +++ b/inst/GUI/simple.R @@ -0,0 +1,68 @@ +# Work in progress - simple GUI for mkin +w <- gwindow('Simple R GUI for kinetic evaluations', visible=FALSE) +# Project definition {{{ +pr <- gexpandgroup("Project", cont=w) + +n.observed <- 1 +max.n.observed <- 9 +observed.names = c("parent", paste("M", 1:(max.n.observed - 1), sep="")) + +prg <- ggroup(horizontal=FALSE, cont = pr) +prl <- glayout(cont = prg) +prl[1,1] <- glabel("Number of observed variables", cont=prl) +prl[1,2] <- (n.observed.gw = gcombobox( + 1:max.n.observed, + handler = function(h, ...) { + n.observed <<- svalue(n.observed.gw) + filter.expression <- paste("^[1-", n.observed, "]$", sep="") + observed.gw$filter("Index", filter.expression) + }, + cont=prl)) + +observed.gw <- gdf( + items = data.frame(Index = 1:max.n.observed, + Name = observed.names, stringsAsFactors=FALSE), + name = "Names of observed variables", + width = 500, height=250, cont=prg) + +addSpace(prg, 15) +prf <- gfile("Project file in binary R format (preferably use .RData as extension)", + container = prg) +addSpring(prg) +addSpace(prg, 15) +pr.ok <- gbutton("save", + handler=function(h,...) { + galert(svalue(prf), parent=w) + }, container=prg) + +gbutton("ok", handler = function(h, ...) { + observed <- observed.gw[1:n.observed,2] + save(observed, file="observed.RData") + visible(pr) <- FALSE + }, + cont=prg +) + +visible(pr) <- TRUE +# }}} + +# Dataset definition +ds <- gexpandgroup("Datasets", cont=w) +s <- gdf(data.frame( Author = c("Meier"), Year = "3", Title = "4"), + name = "Studies", +cont=ds) + +size(s) <- c(800,200) +visible(ds) <- TRUE + +# Model definition +ms <- gexpandgroup("Models", cont=w) +visible(ms) <- FALSE + +# Evaluation window +mw <- gframe("Evaluations", cont=w) + +# Status bar +gstatusbar("Powered by gWidgetsWWW", cont = w) +visible(w) <- TRUE +# vim: set foldmethod=marker: diff --git a/inst/GUI/test.R b/inst/GUI/test.R new file mode 100644 index 0000000..e33e077 --- /dev/null +++ b/inst/GUI/test.R @@ -0,0 +1,17 @@ +require(gWidgetsWWW) +localServerStart("simple.R") + +localServerStart("gdf-test.R") +localServerStart("gdf-test-john.R") + +localServerStart("Examples/ex-actions.R", package="gWidgetsWWW") +localServerStart("Examples/ex-add-widget-dynamically.R", package="gWidgetsWWW") +localServerStart("Examples/ex-clt.R", package="gWidgetsWWW") +localServerStart("Examples/ex-form.R", package="gWidgetsWWW") +localServerStart("Examples/ex-gcombobox.R", package="gWidgetsWWW") +localServerStart("Examples/ex-gtable.R", package="gWidgetsWWW") +localServerStart("Examples/ex-index.R", package="gWidgetsWWW") +localServerStart("Examples/ex-layouts.R", package="gWidgetsWWW") +localServerStart("Examples/ex-simple-gui.R", package="gWidgetsWWW") 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from the FOCUS kinetics -report as distributed with the \Rpackage{kinfit} package +report as distributed with the \Rpackage{mkin} package <>= library("mkin") @@ -101,8 +102,9 @@ as shown in the following listing <>= example_data <- data.frame( + name = rep("parent", 9), time = c(0, 1, 3, 7, 14, 28, 63, 91, 119), - parent = c(85.1, 57.9, 29.9, 14.6, 9.7, 6.6, 4, 3.9, 0.6) + value = c(85.1, 57.9, 29.9, 14.6, 9.7, 6.6, 4, 3.9, 0.6) ) @ @@ -122,12 +124,23 @@ SFORB_SFO <- mkinmod( m1 = list(type = "SFO")) @ +The model definitions given above define sets of linear first-order ordinary +differential equations. In these cases, a coefficient matrix is also returned. + +Other models that include time on the right-hand side of the differential +equation are the first-order multi-compartment (FOMC) model and the +Hockey-Stick (HS) model. At present, only the FOMC model can only be used, and +only for the parent compound. + \subsection{Fitting the model} Then the model parameters should be fitted to the data. The function \Robject{mkinfit} internally creates a cost function using \Robject{modCost} from the \Rpackage{FME} package and the produces a fit using \Robject{modFit} -from the same package. +from the same package. In cases of linear first-order differential +equations, the solution used for calculating the cost function is based +on the fundamental system of the coefficient matrix, as proposed by +\citet{bates88}. <>= # Do not show significance stars as they interfere with vignette generation @@ -136,8 +149,10 @@ SFO.fit <- mkinfit(SFO, FOCUS_2006_C) summary(SFO.fit) SFORB.fit <- mkinfit(SFORB, FOCUS_2006_C) summary(SFORB.fit) -SFO_SFO.fit <- mkinfit(SFO_SFO, FOCUS_2006_D) -summary(SFO_SFO.fit) +SFO_SFO.fit <- mkinfit(SFO_SFO, FOCUS_2006_D, plot=TRUE) +summary(SFO_SFO.fit, data=FALSE) +SFORB_SFO.fit <- mkinfit(SFORB_SFO, FOCUS_2006_D, plot=TRUE) +summary(SFORB_SFO.fit, data=FALSE) @ \bibliographystyle{plainnat} diff --git a/inst/doc/mkin.pdf b/inst/doc/mkin.pdf index 4d2e1d1..f963d1e 100644 Binary files a/inst/doc/mkin.pdf and b/inst/doc/mkin.pdf differ diff --git a/inst/doc/references.bib b/inst/doc/references.bib index b158eeb..24672e2 100644 --- a/inst/doc/references.bib +++ b/inst/doc/references.bib @@ -53,3 +53,10 @@ address = {Piacenza}, pages = {916--923} } + +@Book{ bates88, + title = {Nonlinear regression and its applications}, + author = {D. Bates and D. Watts}, + year = {1988}, + publisher = {Wiley-Interscience} +} diff --git a/inst/unitTests/runit.mkinfit.R b/inst/unitTests/runit.mkinfit.R index df09cc6..831c069 100644 --- a/inst/unitTests/runit.mkinfit.R +++ b/inst/unitTests/runit.mkinfit.R @@ -1,3 +1,23 @@ +# $Id: runit.mkinfit.R 68 2010-09-09 22:40:04Z jranke $ + +# Copyright (C) 2010 Johannes Ranke +# Contact: mkin-devel@lists.berlios.de + +# This file is part of the R package mkin + +# mkin is free software: you can redistribute it and/or modify it under the +# terms of the GNU General Public License as published by the Free Software +# Foundation, either version 3 of the License, or (at your option) any later +# version. + +# This program is distributed in the hope that it will be useful, but WITHOUT +# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS +# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more +# details. + +# You should have received a copy of the GNU General Public License along with +# this program. If not, see + test.mkinmod.schaefer07_complex_example <- function() { schaefer07_complex_model <- mkinmod( @@ -17,16 +37,16 @@ test.mkinmod.schaefer07_complex_example <- function() r$mkin <- c( k_parent, s$distimes["parent", "DT50"], - k_parent_A1/k_parent, + s$ff["parent_A1"], sum(k_A1_sink, k_A1_A2), s$distimes["A1", "DT50"], - k_parent_B1/k_parent, + s$ff["parent_B1"], k_B1_sink, s$distimes["B1", "DT50"], - k_parent_C1/k_parent, + s$ff["parent_C1"], k_C1_sink, s$distimes["C1", "DT50"], - k_A1_A2/(k_A1_A2 + k_A1_sink), + s$ff["A1_A2"], k_A2_sink, s$distimes["A2", "DT50"]) r$means <- (r$KinGUI + r$ModelMaker)/2 diff --git a/inst/unitTests/runit.mkinmod.R b/inst/unitTests/runit.mkinmod.R index 44d9ffb..a0e8996 100644 --- a/inst/unitTests/runit.mkinmod.R +++ b/inst/unitTests/runit.mkinmod.R @@ -1,3 +1,23 @@ +# $Id: runit.mkinmod.R 64 2010-09-01 13:33:51Z jranke $ + +# Copyright (C) 2010 Johannes Ranke +# Contact: mkin-devel@lists.berlios.de + +# This file is part of the R package mkin + +# mkin is free software: you can redistribute it and/or modify it under the +# terms of the GNU General Public License as published by the Free Software +# Foundation, either version 3 of the License, or (at your option) any later +# version. + +# This program is distributed in the hope that it will be useful, but WITHOUT +# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS +# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more +# details. + +# You should have received a copy of the GNU General Public License along with +# this program. If not, see + test.mkinmod.SFO <- function() { SFO.diffs <- c( @@ -5,7 +25,9 @@ test.mkinmod.SFO <- function() ) SFO.parms <- c("k_parent_sink") SFO.map <- list(parent = c(SFO = "parent")) - SFO <- list(diffs = SFO.diffs, parms = SFO.parms, map = SFO.map) + SFO.coefmat <- matrix("- k_parent_sink", dimnames = list("parent", "parent")) + SFO <- list(diffs = SFO.diffs, parms = SFO.parms, map = SFO.map, + coefmat = SFO.coefmat) class(SFO) <- "mkinmod" SFO.1 <- mkinmod( parent = list(type = "SFO", to = NULL, sink = TRUE) @@ -39,7 +61,13 @@ test.mkinmod.SFORB <- function() ) SFORB.parms <- c("k_parent_free_sink", "k_parent_free_bound", "k_parent_bound_free") SFORB.map <- list(parent = c(SFORB = "parent_free", SFORB = "parent_bound")) - SFORB <- list(diffs = SFORB.diffs, parms = SFORB.parms, map = SFORB.map) + vars <- paste("parent", c("free", "bound"), sep="_") + SFORB.coefmat <- matrix( + c("- k_parent_free_sink - k_parent_free_bound", "k_parent_bound_free", + "k_parent_free_bound", "- k_parent_bound_free"), nrow=2, byrow=TRUE, + dimnames=list(vars, vars)) + SFORB <- list(diffs = SFORB.diffs, parms = SFORB.parms, + map = SFORB.map, coefmat = SFORB.coefmat) class(SFORB) <- "mkinmod" SFORB.mkinmod <- mkinmod( parent = list(type = "SFORB", to = NULL, sink=TRUE) @@ -55,7 +83,12 @@ test.mkinmod.SFO_SFO <- function() ) SFO_SFO.parms <- c("k_parent_sink", "k_m1_sink", "k_parent_m1") SFO_SFO.map <- list(parent = c(SFO = "parent"), m1 = c(SFO = "m1")) - SFO_SFO <- list(diffs = SFO_SFO.diffs, parms = SFO_SFO.parms, map = SFO_SFO.map) + vars <- c("parent", "m1") + SFO_SFO.coefmat <- matrix(c("- k_parent_sink - k_parent_m1", + "0", "k_parent_m1", "- k_m1_sink"), nrow=2, byrow=TRUE, + dimnames=list(vars, vars)) + SFO_SFO <- list(diffs = SFO_SFO.diffs, parms = SFO_SFO.parms, + map = SFO_SFO.map, coefmat = SFO_SFO.coefmat) class(SFO_SFO) <- "mkinmod" SFO_SFO.mkinmod <- mkinmod( parent = list(type = "SFO", to = "m1", sink=TRUE), @@ -73,7 +106,14 @@ test.mkinmod.SFO_SFO2 <- function() ) SFO_SFO2.parms <- c("k_parent_sink", "k_m1_sink", "k_m2_sink", "k_parent_m1", "k_parent_m2") SFO_SFO2.map <- list(parent = c(SFO = "parent"), m1 = c(SFO = "m1"), m2 = c(SFO = "m2")) - SFO_SFO2 <- list(diffs = SFO_SFO2.diffs, parms = SFO_SFO2.parms, map = SFO_SFO2.map) + vars <- c("parent", "m1", "m2") + SFO_SFO2.coefmat <- matrix( + c("- k_parent_sink - k_parent_m1 - k_parent_m2", "0", "0", + "k_parent_m1", "- k_m1_sink", "0", + "k_parent_m2", "0", "- k_m2_sink"), nrow=3, byrow=TRUE, + dimnames=list(vars, vars)) + SFO_SFO2 <- list(diffs = SFO_SFO2.diffs, parms = SFO_SFO2.parms, + map = SFO_SFO2.map, coefmat = SFO_SFO2.coefmat) class(SFO_SFO2) <- "mkinmod" SFO_SFO2.mkinmod <- mkinmod( parent = list(type = "SFO", to = c("m1", "m2"), sink=TRUE), @@ -90,9 +130,16 @@ test.mkinmod.FOMC_SFO2 <- function() m1 = "d_m1 = - k_m1_sink * m1 + f_to_m1 * (alpha/beta) * ((time/beta) + 1)^-1 * parent", m2 = "d_m2 = - k_m2_sink * m2 + (1 - f_to_m1) * f_to_m2 * (alpha/beta) * ((time/beta) + 1)^-1 * parent" ) - FOMC_SFO2.parms <- c("alpha", "beta", "k_m1_sink", "k_m2_sink", "f_to_m1", "f_to_m2") - FOMC_SFO2.map <- list(parent = c(FOMC = "parent"), m1 = c(SFO = "m1"), m2 = c(SFO = "m2")) - FOMC_SFO2 <- list(diffs = FOMC_SFO2.diffs, parms = FOMC_SFO2.parms, map = FOMC_SFO2.map) + FOMC_SFO2.parms <- c("alpha", "beta", "k_m1_sink", "k_m2_sink", + "f_to_m1", "f_to_m2") + FOMC_SFO2.map <- list(parent = c(FOMC = "parent"), + m1 = c(SFO = "m1"), + m2 = c(SFO = "m2")) + FOMC_SFO2.ff <- c( + m1 = "f_to_m1", + m2 = "(1 - f_to_m1) * f_to_m2") + FOMC_SFO2 <- list(diffs = FOMC_SFO2.diffs, parms = FOMC_SFO2.parms, + map = FOMC_SFO2.map, ff = FOMC_SFO2.ff) class(FOMC_SFO2) <- "mkinmod" FOMC_SFO2.mkinmod <- mkinmod( parent = list(type = "FOMC", to = c("m1", "m2"), sink=TRUE), -- cgit v1.2.1