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<meta property="og:description" content="This function calculates DT50 and DT90 values as well as formation fractions
from kinetic models fitted with mkinfit. If the SFORB model was specified
for one of the parents or metabolites, the Eigenvalues are returned. These
are equivalent to the rate constants of the DFOP model, but with the
advantage that the SFORB model can also be used for metabolites." />
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<h1>Function to calculate endpoints for further use from kinetic models fitted
with mkinfit</h1>
<small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/endpoints.R'><code>R/endpoints.R</code></a></small>
<div class="hidden name"><code>endpoints.Rd</code></div>
</div>
<div class="ref-description">
<p>This function calculates DT50 and DT90 values as well as formation fractions
from kinetic models fitted with mkinfit. If the SFORB model was specified
for one of the parents or metabolites, the Eigenvalues are returned. These
are equivalent to the rate constants of the DFOP model, but with the
advantage that the SFORB model can also be used for metabolites.</p>
</div>
<pre class="usage"><span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span></pre>
<h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
<table class="ref-arguments">
<colgroup><col class="name" /><col class="desc" /></colgroup>
<tr>
<th>fit</th>
<td><p>An object of class <a href='mkinfit.html'>mkinfit</a>, <a href='nlme.mmkin.html'>nlme.mmkin</a> or
<a href='saem.html'>saem.mmkin</a>. Or another object that has list components
mkinmod containing an <a href='mkinmod.html'>mkinmod</a> degradation model, and two numeric vectors,
bparms.optim and bparms.fixed, that contain parameter values
for that model.</p></td>
</tr>
</table>
<h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
<p>A list with a matrix of dissipation times named distimes,
and, if applicable, a vector of formation fractions named ff
and, if the SFORB model was in use, a vector of eigenvalues
of these SFORB models, equivalent to DFOP rate constants</p>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p>Additional DT50 values are calculated from the FOMC DT90 and k1 and k2 from
HS and DFOP, as well as from Eigenvalues b1 and b2 of any SFORB models</p>
<h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2>
<p>The function is used internally by <a href='summary.mkinfit.html'>summary.mkinfit</a>,
<a href='summary.nlme.mmkin.html'>summary.nlme.mmkin</a> and <a href='summary.saem.mmkin.html'>summary.saem.mmkin</a>.</p>
<h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2>
<p>Johannes Ranke</p>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'>
<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
<span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span>
</div><div class='output co'>#> $distimes
#> DT50 DT90 DT50back
#> parent 1.785233 15.1479 4.559973
#> </div><div class='input'> <span class='co'># \dontrun{</span>
<span class='va'>fit_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
<span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit_2</span><span class='op'>)</span>
</div><div class='output co'>#> $distimes
#> DT50 DT90 DT50back DT50_k1 DT50_k2
#> parent 1.886925 21.25106 6.397207 1.508293 38.83438
#> </div><div class='input'> <span class='va'>fit_3</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFORB"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
<span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit_3</span><span class='op'>)</span>
</div><div class='output co'>#> $ff
#> parent_free
#> 1
#>
#> $SFORB
#> parent_b1 parent_b2
#> 0.4595574 0.0178488
#>
#> $distimes
#> DT50 DT90 DT50back DT50_parent_b1 DT50_parent_b2
#> parent 1.886925 21.25106 6.397208 1.508293 38.83438
#> </div><div class='input'> <span class='co'># }</span>
</div></pre>
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