diff options
author | Johannes Ranke <jranke@uni-bremen.de> | 2022-10-28 13:39:15 +0200 |
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committer | Johannes Ranke <jranke@uni-bremen.de> | 2022-10-28 13:39:15 +0200 |
commit | f820bf5b91be0f589de16c3e3250f5f79672df75 (patch) | |
tree | 2b1406e1c9286634ca017db586e09e2299dec048 /R/parhist.R | |
parent | b1740ade9a1746ccdb325b95915ef88872489f03 (diff) |
Rename parhist to parplot and make it generic
That parhist name was not the brightest idea, as it does
not show histograms.
Diffstat (limited to 'R/parhist.R')
-rw-r--r-- | R/parhist.R | 99 |
1 files changed, 0 insertions, 99 deletions
diff --git a/R/parhist.R b/R/parhist.R deleted file mode 100644 index 0f9c9964..00000000 --- a/R/parhist.R +++ /dev/null @@ -1,99 +0,0 @@ -#' Plot parameter distributions from multistart objects -#' -#' Produces a boxplot with all parameters from the multiple runs, scaled -#' either by the parameters of the run with the highest likelihood, -#' or by their medians as proposed in the paper by Duchesne et al. (2021). -#' -#' @param object The [multistart] object -#' @param llmin The minimum likelihood of objects to be shown -#' @param scale By default, scale parameters using the best available fit. -#' If 'median', parameters are scaled using the median parameters from all fits. -#' @param main Title of the plot -#' @param lpos Positioning of the legend. -#' @param \dots Passed to [boxplot] -#' @references Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -#' identifiability in the frame of nonlinear mixed effects models: the example -#' of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -#' doi: 10.1186/s12859-021-04373-4. -#' @seealso [multistart] -#' @importFrom stats median -#' @export -parhist <- function(object, llmin = -Inf, scale = c("best", "median"), - lpos = "bottomleft", main = "", ...) -{ - oldpar <- par(no.readonly = TRUE) - on.exit(par(oldpar, no.readonly = TRUE)) - - orig <- attr(object, "orig") - orig_parms <- parms(orig) - start_parms <- orig$mean_dp_start - all_parms <- parms(object) - - if (inherits(object, "multistart.saem.mmkin")) { - llfunc <- function(object) { - if (inherits(object$so, "try-error")) return(NA) - else return(logLik(object$so)) - } - } else { - stop("parhist is only implemented for multistart.saem.mmkin objects") - } - ll <- sapply(object, llfunc) - selected <- which(ll > llmin) - selected_parms <- all_parms[selected, ] - - par(las = 1) - if (orig$transformations == "mkin") { - degparm_names_transformed <- names(start_parms) - degparm_index <- which(names(orig_parms) %in% degparm_names_transformed) - orig_parms[degparm_names_transformed] <- backtransform_odeparms( - orig_parms[degparm_names_transformed], - orig$mmkin[[1]]$mkinmod, - transform_rates = orig$mmkin[[1]]$transform_rates, - transform_fractions = orig$mmkin[[1]]$transform_fractions) - start_parms <- backtransform_odeparms(start_parms, - orig$mmkin[[1]]$mkinmod, - transform_rates = orig$mmkin[[1]]$transform_rates, - transform_fractions = orig$mmkin[[1]]$transform_fractions) - degparm_names <- names(start_parms) - - names(orig_parms) <- c(degparm_names, names(orig_parms[-degparm_index])) - - selected_parms[, degparm_names_transformed] <- - t(apply(selected_parms[, degparm_names_transformed], 1, backtransform_odeparms, - orig$mmkin[[1]]$mkinmod, - transform_rates = orig$mmkin[[1]]$transform_rates, - transform_fractions = orig$mmkin[[1]]$transform_fractions)) - colnames(selected_parms)[1:length(degparm_names)] <- degparm_names - } - - scale <- match.arg(scale) - parm_scale <- switch(scale, - best = selected_parms[which.best(object[selected]), ], - median = apply(selected_parms, 2, median) - ) - - # Boxplots of all scaled parameters - selected_scaled_parms <- t(apply(selected_parms, 1, function(x) x / parm_scale)) - boxplot(selected_scaled_parms, log = "y", main = main, , - ylab = "Normalised parameters", ...) - - # Show starting parameters - start_scaled_parms <- rep(NA_real_, length(orig_parms)) - names(start_scaled_parms) <- names(orig_parms) - start_scaled_parms[names(start_parms)] <- - start_parms / parm_scale[names(start_parms)] - points(start_scaled_parms, col = 3, cex = 3) - - # Show parameters of original run - orig_scaled_parms <- orig_parms / parm_scale - points(orig_scaled_parms, col = 2, cex = 2) - - abline(h = 1, lty = 2) - - legend(lpos, inset = c(0.05, 0.05), bty = "n", - pch = 1, col = 3:1, lty = c(NA, NA, 1), - legend = c( - "Starting parameters", - "Original run", - "Multistart runs")) -} |