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authorJohannes Ranke <jranke@uni-bremen.de>2022-10-28 13:39:15 +0200
committerJohannes Ranke <jranke@uni-bremen.de>2022-10-28 13:39:15 +0200
commitf820bf5b91be0f589de16c3e3250f5f79672df75 (patch)
tree2b1406e1c9286634ca017db586e09e2299dec048 /R/parhist.R
parentb1740ade9a1746ccdb325b95915ef88872489f03 (diff)
Rename parhist to parplot and make it generic
That parhist name was not the brightest idea, as it does not show histograms.
Diffstat (limited to 'R/parhist.R')
-rw-r--r--R/parhist.R99
1 files changed, 0 insertions, 99 deletions
diff --git a/R/parhist.R b/R/parhist.R
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-#' Plot parameter distributions from multistart objects
-#'
-#' Produces a boxplot with all parameters from the multiple runs, scaled
-#' either by the parameters of the run with the highest likelihood,
-#' or by their medians as proposed in the paper by Duchesne et al. (2021).
-#'
-#' @param object The [multistart] object
-#' @param llmin The minimum likelihood of objects to be shown
-#' @param scale By default, scale parameters using the best available fit.
-#' If 'median', parameters are scaled using the median parameters from all fits.
-#' @param main Title of the plot
-#' @param lpos Positioning of the legend.
-#' @param \dots Passed to [boxplot]
-#' @references Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical
-#' identifiability in the frame of nonlinear mixed effects models: the example
-#' of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478.
-#' doi: 10.1186/s12859-021-04373-4.
-#' @seealso [multistart]
-#' @importFrom stats median
-#' @export
-parhist <- function(object, llmin = -Inf, scale = c("best", "median"),
- lpos = "bottomleft", main = "", ...)
-{
- oldpar <- par(no.readonly = TRUE)
- on.exit(par(oldpar, no.readonly = TRUE))
-
- orig <- attr(object, "orig")
- orig_parms <- parms(orig)
- start_parms <- orig$mean_dp_start
- all_parms <- parms(object)
-
- if (inherits(object, "multistart.saem.mmkin")) {
- llfunc <- function(object) {
- if (inherits(object$so, "try-error")) return(NA)
- else return(logLik(object$so))
- }
- } else {
- stop("parhist is only implemented for multistart.saem.mmkin objects")
- }
- ll <- sapply(object, llfunc)
- selected <- which(ll > llmin)
- selected_parms <- all_parms[selected, ]
-
- par(las = 1)
- if (orig$transformations == "mkin") {
- degparm_names_transformed <- names(start_parms)
- degparm_index <- which(names(orig_parms) %in% degparm_names_transformed)
- orig_parms[degparm_names_transformed] <- backtransform_odeparms(
- orig_parms[degparm_names_transformed],
- orig$mmkin[[1]]$mkinmod,
- transform_rates = orig$mmkin[[1]]$transform_rates,
- transform_fractions = orig$mmkin[[1]]$transform_fractions)
- start_parms <- backtransform_odeparms(start_parms,
- orig$mmkin[[1]]$mkinmod,
- transform_rates = orig$mmkin[[1]]$transform_rates,
- transform_fractions = orig$mmkin[[1]]$transform_fractions)
- degparm_names <- names(start_parms)
-
- names(orig_parms) <- c(degparm_names, names(orig_parms[-degparm_index]))
-
- selected_parms[, degparm_names_transformed] <-
- t(apply(selected_parms[, degparm_names_transformed], 1, backtransform_odeparms,
- orig$mmkin[[1]]$mkinmod,
- transform_rates = orig$mmkin[[1]]$transform_rates,
- transform_fractions = orig$mmkin[[1]]$transform_fractions))
- colnames(selected_parms)[1:length(degparm_names)] <- degparm_names
- }
-
- scale <- match.arg(scale)
- parm_scale <- switch(scale,
- best = selected_parms[which.best(object[selected]), ],
- median = apply(selected_parms, 2, median)
- )
-
- # Boxplots of all scaled parameters
- selected_scaled_parms <- t(apply(selected_parms, 1, function(x) x / parm_scale))
- boxplot(selected_scaled_parms, log = "y", main = main, ,
- ylab = "Normalised parameters", ...)
-
- # Show starting parameters
- start_scaled_parms <- rep(NA_real_, length(orig_parms))
- names(start_scaled_parms) <- names(orig_parms)
- start_scaled_parms[names(start_parms)] <-
- start_parms / parm_scale[names(start_parms)]
- points(start_scaled_parms, col = 3, cex = 3)
-
- # Show parameters of original run
- orig_scaled_parms <- orig_parms / parm_scale
- points(orig_scaled_parms, col = 2, cex = 2)
-
- abline(h = 1, lty = 2)
-
- legend(lpos, inset = c(0.05, 0.05), bty = "n",
- pch = 1, col = 3:1, lty = c(NA, NA, 1),
- legend = c(
- "Starting parameters",
- "Original run",
- "Multistart runs"))
-}

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