Update online docs

author: Johannes Ranke <jranke@uni-bremen.de> 2022-11-14 21:47:45 +0100
committer: Johannes Ranke <jranke@uni-bremen.de> 2022-11-14 21:47:45 +0100
commit: 9275bcb39b5ee25753ef489d334b4906401970b3 (patch)
tree: 9ddaaf518f8655f38a44f1a0516335989085d490 /docs
parent: d6168b0851a52adeaed8099e41a960d79acedae9 (diff)
34 files changed, 1760 insertions, 1704 deletions
diff --git a/docs/dev/articles/index.html b/docs/dev/articles/index.html
index 45ba1c77..d7af1f11 100644
--- a/docs/dev/articles/index.html
+++ b/docs/dev/articles/index.html
@@ -107,6 +107,8 @@
         <dd>
         </dd><dt><a href="web_only/multistart.html">Short demo of the multistart method</a></dt>
         <dd>
+        </dd><dt><a href="web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a></dt>
+        <dd>
       </dd></dl></div>
   </div>
 </div>
diff --git a/docs/dev/articles/web_only/benchmarks.html b/docs/dev/articles/web_only/benchmarks.html
index 2aa2f45a..cb048453 100644
--- a/docs/dev/articles/web_only/benchmarks.html
+++ b/docs/dev/articles/web_only/benchmarks.html
@@ -109,7 +109,7 @@
       <h1 data-toc-skip>Benchmark timings for mkin</h1>
                         <h4 data-toc-skip class="author">Johannes Ranke</h4>
             
-            <h4 data-toc-skip class="date">Last change 14 July 2022 (rebuilt 2022-11-01)</h4>
+            <h4 data-toc-skip class="date">Last change 14 July 2022 (rebuilt 2022-11-14)</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/benchmarks.rmd" class="external-link"><code>vignettes/web_only/benchmarks.rmd</code></a></small>
       <div class="hidden name"><code>benchmarks.rmd</code></div>
@@ -153,7 +153,7 @@
 <span>  parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span>
 <span>  m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span>
 <span><span class="va">DFOP_SFO</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span>
-<span>  parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span>
+<span>  parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>, <span class="co"># erroneously used FOMC twice, not fixed for consistency</span></span>
 <span>  m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span>
 <span><span class="va">t3</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
 <span><span class="va">t4</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>,</span>
@@ -348,8 +348,8 @@
 <td align="left">Ryzen 7 1700</td>
 <td align="left">4.2.2</td>
 <td align="left">1.2.0</td>
-<td align="right">2.020</td>
-<td align="right">3.608</td>
+<td align="right">2.030</td>
+<td align="right">3.791</td>
 </tr>
 </tbody>
 </table>
@@ -528,8 +528,8 @@
 <td align="left">4.2.2</td>
 <td align="left">1.2.0</td>
 <td align="right">1.579</td>
-<td align="right">5.973</td>
-<td align="right">2.839</td>
+<td align="right">6.591</td>
+<td align="right">3.107</td>
 </tr>
 </tbody>
 </table>
@@ -761,12 +761,12 @@
 <td align="left">Ryzen 7 1700</td>
 <td align="left">4.2.2</td>
 <td align="left">1.2.0</td>
-<td align="right">0.920</td>
-<td align="right">1.295</td>
-<td align="right">1.518</td>
-<td align="right">3.060</td>
-<td align="right">1.895</td>
-<td align="right">2.740</td>
+<td align="right">0.915</td>
+<td align="right">1.426</td>
+<td align="right">1.613</td>
+<td align="right">3.224</td>
+<td align="right">2.068</td>
+<td align="right">2.962</td>
 </tr>
 </tbody>
 </table>
diff --git a/docs/dev/articles/web_only/saem_benchmarks.html b/docs/dev/articles/web_only/saem_benchmarks.html
new file mode 100644
index 00000000..97ea6fd4
--- /dev/null
+++ b/docs/dev/articles/web_only/saem_benchmarks.html
@@ -0,0 +1,415 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en">
+<head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta http-equiv="X-UA-Compatible" content="IE=edge">
+<meta name="viewport" content="width=device-width, initial-scale=1.0">
+<title>Benchmark timings for saem.mmkin • mkin</title>
+<!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous">
+<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../../bootstrap-toc.css">
+<script src="../../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
+<!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../../pkgdown.css" rel="stylesheet">
+<script src="../../pkgdown.js"></script><meta property="og:title" content="Benchmark timings for saem.mmkin">
+<meta property="og:description" content="mkin">
+<meta name="robots" content="noindex">
+<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]-->
+</head>
+<body data-spy="scroll" data-target="#toc">
+    
+
+    <div class="container template-article">
+      <header><div class="navbar navbar-default navbar-fixed-top" role="navigation">
+  <div class="container">
+    <div class="navbar-header">
+      <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false">
+        <span class="sr-only">Toggle navigation</span>
+        <span class="icon-bar"></span>
+        <span class="icon-bar"></span>
+        <span class="icon-bar"></span>
+      </button>
+      <span class="navbar-brand">
+        <a class="navbar-link" href="../../index.html">mkin</a>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
+      </span>
+    </div>
+
+    <div id="navbar" class="navbar-collapse collapse">
+      <ul class="nav navbar-nav">
+<li>
+  <a href="../../reference/index.html">Functions and data</a>
+</li>
+<li class="dropdown">
+  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false">
+    Articles
+     
+    <span class="caret"></span>
+  </a>
+  <ul class="dropdown-menu" role="menu">
+<li>
+      <a href="../../articles/mkin.html">Introduction to mkin</a>
+    </li>
+    <li>
+      <a href="../../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a>
+    </li>
+    <li>
+      <a href="../../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/multistart.html">Short demo of the multistart method</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+    </li>
+    <li>
+      <a href="../../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a>
+    </li>
+    <li>
+      <a href="../../articles/web_only/benchmarks.html">Some benchmark timings</a>
+    </li>
+  </ul>
+</li>
+<li>
+  <a href="../../news/index.html">News</a>
+</li>
+      </ul>
+<ul class="nav navbar-nav navbar-right">
+<li>
+  <a href="https://github.com/jranke/mkin/" class="external-link">
+    <span class="fab fa-github fa-lg"></span>
+     
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+</li>
+      </ul>
+</div>
+<!--/.nav-collapse -->
+  </div>
+<!--/.container -->
+</div>
+<!--/.navbar -->
+
+      
+
+      </header><script src="saem_benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row">
+  <div class="col-md-9 contents">
+    <div class="page-header toc-ignore">
+      <h1 data-toc-skip>Benchmark timings for saem.mmkin</h1>
+                        <h4 data-toc-skip class="author">Johannes Ranke</h4>
+            
+            <h4 data-toc-skip class="date">Last change 14 November 2022 (rebuilt 2022-11-14)</h4>
+      
+      <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/saem_benchmarks.rmd" class="external-link"><code>vignettes/web_only/saem_benchmarks.rmd</code></a></small>
+      <div class="hidden name"><code>saem_benchmarks.rmd</code></div>
+
+    </div>
+
+    
+    
+<p>Each system is characterized by operating system type, CPU type, mkin version, saemix version and R version. A compiler was available, so if no analytical solution was available, compiled ODE models are used.</p>
+<p>Every fit is only performed once, so the accuracy of the benchmarks is limited.</p>
+<p>For the initial mmkin fits, we use all available cores.</p>
+<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">n_cores</span> <span class="op">&lt;-</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div>
+<div class="section level2">
+<h2 id="test-data">Test data<a class="anchor" aria-label="anchor" href="#test-data"></a>
+</h2>
+<p>Please refer to the vignette <code>dimethenamid_2018</code> for an explanation of the following preprocessing.</p>
+<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">dmta_ds</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span>
+<span>  <span class="va">ds_i</span> <span class="op">&lt;-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span>
+<span>  <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op">&lt;-</span>  <span class="st">"DMTA"</span></span>
+<span>  <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">&lt;-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span>
+<span>  <span class="va">ds_i</span></span>
+<span><span class="op">}</span><span class="op">)</span></span>
+<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span>
+<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span>
+<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op">&lt;-</span> <span class="cn">NULL</span></span>
+<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op">&lt;-</span> <span class="cn">NULL</span></span></code></pre></div>
+</div>
+<div class="section level2">
+<h2 id="test-cases">Test cases<a class="anchor" aria-label="anchor" href="#test-cases"></a>
+</h2>
+<div class="section level3">
+<h3 id="parent-only">Parent only<a class="anchor" aria-label="anchor" href="#parent-only"></a>
+</h3>
+<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">parent_mods</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span>, <span class="st">"SFORB"</span>, <span class="st">"HS"</span><span class="op">)</span></span>
+<span><span class="va">parent_sep_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">parent_mods</span>, <span class="va">dmta_ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span></span>
+<span><span class="va">parent_sep_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">parent_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">t1</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sfo_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t2</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t3</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"SFORB"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t4</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">hs_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t5</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sfo_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t6</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t7</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"SFORB"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t8</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">hs_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div>
+<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span></span>
+<span>  <span class="va">sfo_const</span>, <span class="va">dfop_const</span>, <span class="va">sforb_const</span>, <span class="va">hs_const</span>,</span>
+<span>  <span class="va">sfo_tc</span>, <span class="va">dfop_tc</span>, <span class="va">sforb_tc</span>, <span class="va">hs_tc</span><span class="op">)</span> <span class="op">|&gt;</span> <span class="fu">kable</span><span class="op">(</span>, digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div>
+<table class="table">
+<thead><tr class="header">
+<th align="left"></th>
+<th align="right">npar</th>
+<th align="right">AIC</th>
+<th align="right">BIC</th>
+<th align="right">Lik</th>
+</tr></thead>
+<tbody>
+<tr class="odd">
+<td align="left">sfo_const</td>
+<td align="right">5</td>
+<td align="right">796.3</td>
+<td align="right">795.3</td>
+<td align="right">-393.2</td>
+</tr>
+<tr class="even">
+<td align="left">sfo_tc</td>
+<td align="right">6</td>
+<td align="right">798.3</td>
+<td align="right">797.1</td>
+<td align="right">-393.2</td>
+</tr>
+<tr class="odd">
+<td align="left">dfop_const</td>
+<td align="right">9</td>
+<td align="right">709.4</td>
+<td align="right">707.5</td>
+<td align="right">-345.7</td>
+</tr>
+<tr class="even">
+<td align="left">sforb_const</td>
+<td align="right">9</td>
+<td align="right">710.0</td>
+<td align="right">708.1</td>
+<td align="right">-346.0</td>
+</tr>
+<tr class="odd">
+<td align="left">hs_const</td>
+<td align="right">9</td>
+<td align="right">713.7</td>
+<td align="right">711.8</td>
+<td align="right">-347.8</td>
+</tr>
+<tr class="even">
+<td align="left">dfop_tc</td>
+<td align="right">10</td>
+<td align="right">669.8</td>
+<td align="right">667.7</td>
+<td align="right">-324.9</td>
+</tr>
+<tr class="odd">
+<td align="left">sforb_tc</td>
+<td align="right">10</td>
+<td align="right">662.8</td>
+<td align="right">660.7</td>
+<td align="right">-321.4</td>
+</tr>
+<tr class="even">
+<td align="left">hs_tc</td>
+<td align="right">10</td>
+<td align="right">667.3</td>
+<td align="right">665.2</td>
+<td align="right">-323.6</td>
+</tr>
+</tbody>
+</table>
+<p>The above model comparison suggests to use the SFORB model with two-component error. For comparison, we keep the DFOP model with two-component error, as it competes with SFORB for biphasic curves.</p>
+<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">dfop_tc</span><span class="op">)</span></span></code></pre></div>
+<pre><code><span><span class="co">## [1] "sd(log_k2)"</span></span></code></pre>
+<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">sforb_tc</span><span class="op">)</span></span></code></pre></div>
+<pre><code><span><span class="co">## [1] "sd(log_k_DMTA_bound_free)"</span></span></code></pre>
+<p>For these two models, random effects for the transformed parameters <code>k2</code> and <code>k_DMTA_bound_free</code> could not be quantified.</p>
+</div>
+<div class="section level3">
+<h3 id="one-metabolite">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite"></a>
+</h3>
+<p>We remove parameters that were found to be ill-defined in the parent only fits.</p>
+<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">one_met_mods</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span>
+<span>  DFOP_SFO <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span>
+<span>    DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"M23"</span><span class="op">)</span>,</span>
+<span>    M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span>,</span>
+<span>  SFORB_SFO <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span>
+<span>    DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"M23"</span><span class="op">)</span>,</span>
+<span>    M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">one_met_sep_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">one_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"const"</span>,</span>
+<span>  cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span>
+<span><span class="va">one_met_sep_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">one_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span>
+<span>  cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">t9</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_sfo_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">one_met_sep_tc</span><span class="op">[</span><span class="st">"DFOP_SFO"</span>, <span class="op">]</span>,</span>
+<span>    no_random_effect <span class="op">=</span> <span class="st">"log_k2"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span>
+<span><span class="va">t10</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_sfo_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">one_met_sep_tc</span><span class="op">[</span><span class="st">"SFORB_SFO"</span>, <span class="op">]</span>,</span>
+<span>    no_random_effect <span class="op">=</span> <span class="st">"log_k_DMTA_bound_free"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div>
+</div>
+<div class="section level3">
+<h3 id="three-metabolites">Three metabolites<a class="anchor" aria-label="anchor" href="#three-metabolites"></a>
+</h3>
+<p>For the case of three metabolites, we only keep the SFORB model in order to limit the time for compiling this vignette, and as fitting in parallel may disturb the benchmark. Again, we do not include random effects that were ill-defined in previous fits of subsets of the degradation model.</p>
+<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">sforb_sfo_tc</span><span class="op">)</span></span></code></pre></div>
+<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">three_met_mods</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span>
+<span>  SFORB_SFO3_plus <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span>
+<span>    DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span>
+<span>    M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span>
+<span>    M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span>
+<span>    M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">three_met_sep_tc</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">three_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span>
+<span>  cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span>
+<span></span>
+<span><span class="va">t11</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_sfo3_plus_const</span> <span class="op">&lt;-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">three_met_sep_tc</span><span class="op">[</span><span class="st">"SFORB_SFO3_plus"</span>, <span class="op">]</span>,</span>
+<span>    no_random_effect <span class="op">=</span> <span class="st">"log_k_DMTA_bound_free"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div>
+</div>
+</div>
+<div class="section level2">
+<h2 id="results">Results<a class="anchor" aria-label="anchor" href="#results"></a>
+</h2>
+<p>Benchmarks for all available error models are shown. They are intended for improving mkin, not for comparing CPUs or operating systems. All trademarks belong to their respective owners.</p>
+<div class="section level3">
+<h3 id="parent-only-1">Parent only<a class="anchor" aria-label="anchor" href="#parent-only-1"></a>
+</h3>
+<p>Constant variance for SFO, DFOP, SFORB and HS.</p>
+<table class="table">
+<thead><tr class="header">
+<th align="left">CPU</th>
+<th align="left">OS</th>
+<th align="left">mkin</th>
+<th align="left">saemix</th>
+<th align="right">t1</th>
+<th align="right">t2</th>
+<th align="right">t3</th>
+<th align="right">t4</th>
+</tr></thead>
+<tbody><tr class="odd">
+<td align="left">Ryzen 7 1700</td>
+<td align="left">Linux</td>
+<td align="left">1.2.0</td>
+<td align="left">3.2</td>
+<td align="right">2.589</td>
+<td align="right">4.945</td>
+<td align="right">4.786</td>
+<td align="right">4.484</td>
+</tr></tbody>
+</table>
+<p>Two-component error fits for SFO, DFOP, SFORB and HS.</p>
+<table class="table">
+<thead><tr class="header">
+<th align="left">CPU</th>
+<th align="left">OS</th>
+<th align="left">mkin</th>
+<th align="left">saemix</th>
+<th align="right">t5</th>
+<th align="right">t6</th>
+<th align="right">t7</th>
+<th align="right">t8</th>
+</tr></thead>
+<tbody><tr class="odd">
+<td align="left">Ryzen 7 1700</td>
+<td align="left">Linux</td>
+<td align="left">1.2.0</td>
+<td align="left">3.2</td>
+<td align="right">5.645</td>
+<td align="right">8.115</td>
+<td align="right">7.737</td>
+<td align="right">7.782</td>
+</tr></tbody>
+</table>
+</div>
+<div class="section level3">
+<h3 id="one-metabolite-1">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite-1"></a>
+</h3>
+<p>Two-component error for DFOP-SFO and SFORB-SFO.</p>
+<table class="table">
+<thead><tr class="header">
+<th align="left">CPU</th>
+<th align="left">OS</th>
+<th align="left">mkin</th>
+<th align="left">saemix</th>
+<th align="right">t9</th>
+<th align="right">t10</th>
+</tr></thead>
+<tbody><tr class="odd">
+<td align="left">Ryzen 7 1700</td>
+<td align="left">Linux</td>
+<td align="left">1.2.0</td>
+<td align="left">3.2</td>
+<td align="right">25.921</td>
+<td align="right">766.034</td>
+</tr></tbody>
+</table>
+</div>
+<div class="section level3">
+<h3 id="three-metabolites-1">Three metabolites<a class="anchor" aria-label="anchor" href="#three-metabolites-1"></a>
+</h3>
+<p>Two-component error for SFORB-SFO3-plus</p>
+<table class="table">
+<thead><tr class="header">
+<th align="left">CPU</th>
+<th align="left">OS</th>
+<th align="left">mkin</th>
+<th align="left">saemix</th>
+<th align="right">t11</th>
+</tr></thead>
+<tbody><tr class="odd">
+<td align="left">Ryzen 7 1700</td>
+<td align="left">Linux</td>
+<td align="left">1.2.0</td>
+<td align="left">3.2</td>
+<td align="right">1269.799</td>
+</tr></tbody>
+</table>
+</div>
+</div>
+  </div>
+
+  <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
+
+        <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2>
+    </nav>
+</div>
+
+</div>
+
+
+
+      <footer><div class="copyright">
+  <p></p>
+<p>Developed by Johannes Ranke.</p>
+</div>
+
+<div class="pkgdown">
+  <p></p>
+<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
+</div>
+
+      </footer>
+</div>
+
+  
+
+
+  
+
+  </body>
+</html>
diff --git a/docs/dev/articles/web_only/saem_benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/web_only/saem_benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js
new file mode 100644
index 00000000..ca349fd6
--- /dev/null
+++ b/docs/dev/articles/web_only/saem_benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js
@@ -0,0 +1,15 @@
+// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) -->
+// v0.0.1
+// Written by JooYoung Seo (jooyoung@psu.edu) and Atsushi Yasumoto on June 1st, 2020.
+
+document.addEventListener('DOMContentLoaded', function() {
+  const codeList = document.getElementsByClassName("sourceCode");
+  for (var i = 0; i < codeList.length; i++) {
+    var linkList = codeList[i].getElementsByTagName('a');
+    for (var j = 0; j < linkList.length; j++) {
+      if (linkList[j].innerHTML === "") {
+        linkList[j].setAttribute('aria-hidden', 'true');
+      }
+    }
+  }
+});
diff --git a/docs/dev/news/index.html b/docs/dev/news/index.html
index 7eff175c..f363d409 100644
--- a/docs/dev/news/index.html
+++ b/docs/dev/news/index.html
@@ -91,6 +91,7 @@
 <li><p>‘R/illparms.R’: New generic to show ill-defined parameters with methods for ‘mkinfit’, ‘mmkin’, ‘saem.mmkin’ and ‘mhmkin’ objects.</p></li>
 <li><p>‘R/multistart.R’: New method for testing multiple start parameters for hierarchical model fits, with function ‘llhist’ and new generic ‘parplot’ for diagnostics, and new generics ‘which.best’ and ‘best’ for extracting the fit with the highest likelihood</p></li>
 <li><p>‘R/saem.R’: ‘logLik’, ‘update’ and ‘anova’ methods for ‘saem.mmkin’ objects.</p></li>
+<li><p>‘R/saem.R’: Automatic estimation of start parameters for random effects for the case of mkin transformations, nicely improving convergence and reducing problems with iterative ODE solutions.</p></li>
 <li><p>‘R/status.R’: New generic to show status information for fit array objects with methods for ‘mmkin’, ‘mhmkin’ and ‘multistart’ objects.</p></li>
 <li><p>‘R/summary.mmkin.R’: Summary method for mmkin objects.</p></li>
 <li><p>‘R/saem.R’: Implement and test saemix transformations for FOMC and HS. Also, error out if saemix transformations are requested but not supported.</p></li>
diff --git a/docs/dev/pkgdown.yml b/docs/dev/pkgdown.yml
index c5d5d820..5c7a8a3e 100644
--- a/docs/dev/pkgdown.yml
+++ b/docs/dev/pkgdown.yml
@@ -12,7 +12,8 @@ articles:
   compiled_models: web_only/compiled_models.html
   dimethenamid_2018: web_only/dimethenamid_2018.html
   multistart: web_only/multistart.html
-last_built: 2022-11-03T11:38Z
+  saem_benchmarks: web_only/saem_benchmarks.html
+last_built: 2022-11-14T20:05Z
 urls:
   reference: https://pkgdown.jrwb.de/mkin/reference
   article: https://pkgdown.jrwb.de/mkin/articles
diff --git a/docs/dev/reference/DFOP.solution-1.png b/docs/dev/reference/DFOP.solution-1.png
index 616e19d5..5ebba336 100644
--- a/docs/dev/reference/DFOP.solution-1.png
+++ b/docs/dev/reference/DFOP.solution-1.png
diff --git a/docs/dev/reference/DFOP.solution.html b/docs/dev/reference/DFOP.solution.html
index 3ee660f2..f41d8e9b 100644
--- a/docs/dev/reference/DFOP.solution.html
+++ b/docs/dev/reference/DFOP.solution.html
@@ -1,68 +1,13 @@
-<!-- Generated by pkgdown: do not edit by hand -->
 <!DOCTYPE html>
-<html lang="en">
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-  <meta charset="utf-8">
-<meta http-equiv="X-UA-Compatible" content="IE=edge">
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-<!-- jquery -->
-<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
-<!-- Bootstrap -->
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-<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" />
-
-<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script>
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-<script src="../bootstrap-toc.js"></script>
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-<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" />
-
-<!-- clipboard.js -->
-<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script>
-
-<!-- headroom.js -->
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-<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script>
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-<meta property="og:title" content="Double First-Order in Parallel kinetics — DFOP.solution" />
-<meta property="og:description" content="Function describing decline from a defined starting value using the sum of
-two exponential decline functions." />
-
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-
-<!--[if lt IE 9]>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Double First-Order in Parallel kinetics — DFOP.solution • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Double First-Order in Parallel kinetics — DFOP.solution"><meta property="og:description" content="Function describing decline from a defined starting value using the sum of
+two exponential decline functions."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
 <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]-->
-
+<![endif]--></head><body data-spy="scroll" data-target="#toc">
+    
 
-
-  </head>
-
-  <body data-spy="scroll" data-target="#toc">
     <div class="container template-reference-topic">
-      <header>
-      <div class="navbar navbar-default navbar-fixed-top" role="navigation">
+      <header><div class="navbar navbar-default navbar-fixed-top" role="navigation">
   <div class="container">
     <div class="navbar-header">
       <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false">
@@ -73,23 +18,21 @@ two exponential decline functions." />
       </button>
       <span class="navbar-brand">
         <a class="navbar-link" href="../index.html">mkin</a>
-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
       </span>
     </div>
 
     <div id="navbar" class="navbar-collapse collapse">
-      <ul class="nav navbar-nav">
-        <li>
+      <ul class="nav navbar-nav"><li>
   <a href="../reference/index.html">Functions and data</a>
 </li>
 <li class="dropdown">
-  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
+  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false">
     Articles
      
     <span class="caret"></span>
   </a>
-  <ul class="dropdown-menu" role="menu">
-    <li>
+  <ul class="dropdown-menu" role="menu"><li>
       <a href="../articles/mkin.html">Introduction to mkin</a>
     </li>
     <li>
@@ -99,12 +42,18 @@ two exponential decline functions." />
       <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a>
     </li>
     <li>
-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
     </li>
     <li>
       <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a>
     </li>
     <li>
+      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+    </li>
+    <li>
       <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
     </li>
     <li>
@@ -113,34 +62,27 @@ two exponential decline functions." />
     <li>
       <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a>
     </li>
-  </ul>
-</li>
+  </ul></li>
 <li>
   <a href="../news/index.html">News</a>
 </li>
-      </ul>
-      <ul class="nav navbar-nav navbar-right">
-        <li>
-  <a href="https://github.com/jranke/mkin/">
+      </ul><ul class="nav navbar-nav navbar-right"><li>
+  <a href="https://github.com/jranke/mkin/" class="external-link">
     <span class="fab fa-github fa-lg"></span>
      
   </a>
 </li>
-      </ul>
-      
-    </div><!--/.nav-collapse -->
+      </ul></div><!--/.nav-collapse -->
   </div><!--/.container -->
 </div><!--/.navbar -->
 
       
 
-      </header>
-
-<div class="row">
+      </header><div class="row">
   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>Double First-Order in Parallel kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>DFOP.solution.Rd</code></div>
     </div>
 
@@ -149,89 +91,92 @@ two exponential decline functions." />
 two exponential decline functions.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>DFOP.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>g</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>k1</th>
-      <td><p>First kinetic constant.</p></td>
-    </tr>
-    <tr>
-      <th>k2</th>
-      <td><p>Second kinetic constant.</p></td>
-    </tr>
-    <tr>
-      <th>g</th>
-      <td><p>Fraction of the starting value declining according to the first
-kinetic constant.</p></td>
-    </tr>
-    </table>
-
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
-
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
-
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
+
+<dt>k1</dt>
+<dd><p>First kinetic constant.</p></dd>
+
+
+<dt>k2</dt>
+<dd><p>Second kinetic constant.</p></dd>
+
+
+<dt>g</dt>
+<dd><p>Fraction of the starting value declining according to the first
+kinetic constant.</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
-FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
+FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>DFOP.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>5</span>, <span class='fl'>0.5</span>, <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>4</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>,<span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='img'><img src='DFOP.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-</div></pre>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">5</span>, <span class="fl">0.5</span>, <span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">4</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="DFOP.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
-    </nav>
-  </div>
+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
 </div>
 
 
-      <footer>
-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
 </div>
 
 <div class="pkgdown">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
+  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
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diff --git a/docs/dev/reference/FOMC.solution-1.png b/docs/dev/reference/FOMC.solution-1.png
index 1d32355a..9d222d42 100644
--- a/docs/dev/reference/FOMC.solution-1.png
+++ b/docs/dev/reference/FOMC.solution-1.png
diff --git a/docs/dev/reference/FOMC.solution.html b/docs/dev/reference/FOMC.solution.html
index 1a5124e0..f64e759c 100644
--- a/docs/dev/reference/FOMC.solution.html
+++ b/docs/dev/reference/FOMC.solution.html
@@ -1,68 +1,13 @@
-<!-- Generated by pkgdown: do not edit by hand -->
 <!DOCTYPE html>
-<html lang="en">
-  <head>
-  <meta charset="utf-8">
-<meta http-equiv="X-UA-Compatible" content="IE=edge">
-<meta name="viewport" content="width=device-width, initial-scale=1.0">
-
-<title>First-Order Multi-Compartment kinetics — FOMC.solution • mkin</title>
-
-
-<!-- jquery -->
-<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
-<!-- Bootstrap -->
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+a decreasing rate constant."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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+<![endif]--></head><body data-spy="scroll" data-target="#toc">
+    
 
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@@ -73,23 +18,21 @@ a decreasing rate constant." />
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         <a class="navbar-link" href="../index.html">mkin</a>
-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
       </span>
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+      <ul class="nav navbar-nav"><li>
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 </li>
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@@ -99,12 +42,18 @@ a decreasing rate constant." />
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-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
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       <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a>
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+      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+    </li>
+    <li>
       <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
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@@ -113,34 +62,27 @@ a decreasing rate constant." />
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   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>First-Order Multi-Compartment kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>FOMC.solution.Rd</code></div>
     </div>
 
@@ -149,98 +91,103 @@ a decreasing rate constant." />
 a decreasing rate constant.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>FOMC.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>alpha</span>, <span class='va'>beta</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>alpha</th>
-      <td><p>Shape parameter determined by coefficient of variation of rate
-constant values.</p></td>
-    </tr>
-    <tr>
-      <th>beta</th>
-      <td><p>Location parameter.</p></td>
-    </tr>
-    </table>
-
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
-
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">alpha</span>, <span class="va">beta</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
+
+<dt>alpha</dt>
+<dd><p>Shape parameter determined by coefficient of variation of rate
+constant values.</p></dd>
+
+
+<dt>beta</dt>
+<dd><p>Location parameter.</p></dd>
 
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="details">
+    <h2>Details</h2>
     <p>The form given here differs slightly from the original reference by
 Gustafson and Holden (1990). The parameter <code>beta</code> corresponds to 1/beta
 in the original equation.</p>
-    <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2>
-
+    </div>
+    <div id="note">
+    <h2>Note</h2>
     <p>The solution of the FOMC kinetic model reduces to the
-<code><a href='SFO.solution.html'>SFO.solution</a></code> for large values of <code>alpha</code> and
-<code>beta</code> with \(k = \frac{\beta}{\alpha}\).</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
-
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+<code><a href="SFO.solution.html">SFO.solution</a></code> for large values of <code>alpha</code> and <code>beta</code>
+with \(k = \frac{\beta}{\alpha}\).</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-<p>FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+<p>FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
 <p>Gustafson DI and Holden LR (1990) Nonlinear pesticide dissipation in soil:
 A new model based on spatial variability. <em>Environmental Science and
 Technology</em> <b>24</b>, 1032-1038</p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>FOMC.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>10</span>, <span class='fl'>2</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='img'><img src='FOMC.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-</div></pre>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">10</span>, <span class="fl">2</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="FOMC.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
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+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
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-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
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diff --git a/docs/dev/reference/HS.solution-1.png b/docs/dev/reference/HS.solution-1.png
index 32d04b2d..dd7a76c8 100644
--- a/docs/dev/reference/HS.solution-1.png
+++ b/docs/dev/reference/HS.solution-1.png
diff --git a/docs/dev/reference/HS.solution.html b/docs/dev/reference/HS.solution.html
index 1b79e8b6..5fcef9c0 100644
--- a/docs/dev/reference/HS.solution.html
+++ b/docs/dev/reference/HS.solution.html
@@ -1,68 +1,13 @@
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@@ -73,23 +18,21 @@ between them." />
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-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
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+      <ul class="nav navbar-nav"><li>
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@@ -99,12 +42,18 @@ between them." />
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+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
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@@ -113,34 +62,27 @@ between them." />
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   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>Hockey-Stick kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>HS.solution.Rd</code></div>
     </div>
 
@@ -149,90 +91,93 @@ between them." />
 between them.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>HS.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>tb</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>k1</th>
-      <td><p>First kinetic constant.</p></td>
-    </tr>
-    <tr>
-      <th>k2</th>
-      <td><p>Second kinetic constant.</p></td>
-    </tr>
-    <tr>
-      <th>tb</th>
-      <td><p>Break point. Before this time, exponential decline according to
-<code>k1</code> is calculated, after this time, exponential decline proceeds
-according to <code>k2</code>.</p></td>
-    </tr>
-    </table>
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">HS.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">tb</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
 
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
+<dt>k1</dt>
+<dd><p>First kinetic constant.</p></dd>
 
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
 
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+<dt>k2</dt>
+<dd><p>Second kinetic constant.</p></dd>
+
+
+<dt>tb</dt>
+<dd><p>Break point. Before this time, exponential decline according to
+<code>k1</code> is calculated, after this time, exponential decline proceeds
+according to <code>k2</code>.</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
-FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
+FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>HS.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>2</span>, <span class='fl'>0.3</span>, <span class='fl'>0.5</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim<span class='op'>=</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>,<span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='img'><img src='HS.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-</div></pre>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">HS.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">2</span>, <span class="fl">0.3</span>, <span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim<span class="op">=</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="HS.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
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-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
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+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
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+  <p></p><p>Developed by Johannes Ranke.</p>
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diff --git a/docs/dev/reference/IORE.solution-1.png b/docs/dev/reference/IORE.solution-1.png
index 42643a58..9b6ab58f 100644
--- a/docs/dev/reference/IORE.solution-1.png
+++ b/docs/dev/reference/IORE.solution-1.png
diff --git a/docs/dev/reference/IORE.solution.html b/docs/dev/reference/IORE.solution.html
index bc17319e..90eccde9 100644
--- a/docs/dev/reference/IORE.solution.html
+++ b/docs/dev/reference/IORE.solution.html
@@ -1,68 +1,13 @@
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@@ -99,12 +42,18 @@ a concentration dependent rate constant." />
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     <h1>Indeterminate order rate equation kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>IORE.solution.Rd</code></div>
     </div>
 
@@ -149,100 +91,106 @@ a concentration dependent rate constant." />
 a concentration dependent rate constant.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>IORE.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k__iore</span>, <span class='va'>N</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>k__iore</th>
-      <td><p>Rate constant. Note that this depends on the concentration
-units used.</p></td>
-    </tr>
-    <tr>
-      <th>N</th>
-      <td><p>Exponent describing the nonlinearity of the rate equation</p></td>
-    </tr>
-    </table>
-
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
-
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2>
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">IORE.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k__iore</span>, <span class="va">N</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
+
+<dt>k__iore</dt>
+<dd><p>Rate constant. Note that this depends on the concentration
+units used.</p></dd>
 
+
+<dt>N</dt>
+<dd><p>Exponent describing the nonlinearity of the rate equation</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="note">
+    <h2>Note</h2>
     <p>The solution of the IORE kinetic model reduces to the
-<code><a href='SFO.solution.html'>SFO.solution</a></code> if N = 1.  The parameters of the IORE model can
+<code><a href="SFO.solution.html">SFO.solution</a></code> if N = 1.  The parameters of the IORE model can
 be transformed to equivalent parameters of the FOMC mode - see the NAFTA
 guidance for details.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
-
+    </div>
+    <div id="references">
+    <h2>References</h2>
     <p>NAFTA Technical Working Group on Pesticides (not dated) Guidance
 for Evaluating and Calculating Degradation Kinetics in Environmental Media</p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>IORE.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.2</span>, <span class='fl'>1.3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='img'><img src='IORE.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='co'># \dontrun{</span>
-    <span class='va'>fit.fomc</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-    <span class='va'>fit.iore</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"IORE"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-    <span class='va'>fit.iore.deS</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"IORE"</span>, <span class='va'>FOCUS_2006_C</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-
-    <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span><span class='va'>fit.fomc</span><span class='op'>$</span><span class='va'>par</span>, <span class='va'>fit.iore</span><span class='op'>$</span><span class='va'>par</span>, <span class='va'>fit.iore.deS</span><span class='op'>$</span><span class='va'>par</span>, 
-                     row.names <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"model par"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>4</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;             fit.fomc.par fit.iore.par fit.iore.deS.par
-#&gt; model par 1  85.87489063    85.874890        85.874890
-#&gt; model par 2   0.05192238    -4.826631        -4.826631
-#&gt; model par 3   0.65096665     1.949403         1.949403
-#&gt; model par 4   1.85744396     1.857444         1.857444</div><div class='input'>    <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/cbind.html'>rbind</a></span><span class='op'>(</span>fomc <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.fomc</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span>, iore <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.iore</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span>, 
-                iore.deS <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.iore</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;              DT50    DT90 DT50back
-#&gt; fomc     1.785233 15.1479 4.559973
-#&gt; iore     1.785233 15.1479 4.559973
-#&gt; iore.deS 1.785233 15.1479 4.559973</div><div class='input'>  <span class='co'># }</span>
-
-</div></pre>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">IORE.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.2</span>, <span class="fl">1.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="IORE.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span>  <span class="co"># \dontrun{</span></span></span>
+<span class="r-in"><span>    <span class="va">fit.fomc</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="va">fit.iore</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="va">fit.iore.deS</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore.deS</span><span class="op">$</span><span class="va">par</span>,</span></span>
+<span class="r-in"><span>                     row.names <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"model par"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>             fit.fomc.par fit.iore.par fit.iore.deS.par</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> model par 1  85.87489063    85.874890        85.874890</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> model par 2   0.05192238    -4.826631        -4.826631</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> model par 3   0.65096665     1.949403         1.949403</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> model par 4   1.85744396     1.857444         1.857444</span>
+<span class="r-in"><span>    <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span>fomc <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>, iore <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>,</span></span>
+<span class="r-in"><span>                iore.deS <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>              DT50    DT90 DT50back</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> fomc     1.785233 15.1479 4.559973</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> iore     1.785233 15.1479 4.559973</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> iore.deS 1.785233 15.1479 4.559973</span>
+<span class="r-in"><span>  <span class="co"># }</span></span></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
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+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
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index f06a860e..27feab09 100644
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diff --git a/docs/dev/reference/Rplot003.png b/docs/dev/reference/Rplot003.png
index 1af5d4b4..774715e0 100644
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+++ b/docs/dev/reference/Rplot003.png
diff --git a/docs/dev/reference/Rplot004.png b/docs/dev/reference/Rplot004.png
index 12d337a4..37e0e95e 100644
--- a/docs/dev/reference/Rplot004.png
+++ b/docs/dev/reference/Rplot004.png
diff --git a/docs/dev/reference/SFO.solution-1.png b/docs/dev/reference/SFO.solution-1.png
index 56d27ef6..a00499cb 100644
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+++ b/docs/dev/reference/SFO.solution-1.png
diff --git a/docs/dev/reference/SFO.solution.html b/docs/dev/reference/SFO.solution.html
index 43c434c6..970a62c5 100644
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-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
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@@ -98,12 +41,18 @@
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+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
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+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
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       <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
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+      </header><div class="row">
   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>Single First-Order kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>SFO.solution.Rd</code></div>
     </div>
 
@@ -147,80 +89,83 @@
     <p>Function describing exponential decline from a defined starting value.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>SFO.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>k</th>
-      <td><p>Kinetic rate constant.</p></td>
-    </tr>
-    </table>
-
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
-
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
-
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">SFO.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
+
+<dt>k</dt>
+<dd><p>Kinetic rate constant.</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
-FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
+FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>SFO.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span><span class='op'>)</span>
-</div><div class='img'><img src='SFO.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-</div></pre>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFO.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="SFO.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
-    </nav>
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+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
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-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
 </div>
 
 <div class="pkgdown">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
+  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
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diff --git a/docs/dev/reference/SFORB.solution-1.png b/docs/dev/reference/SFORB.solution-1.png
index 4eeb0d41..7bea3b78 100644
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+++ b/docs/dev/reference/SFORB.solution-1.png
diff --git a/docs/dev/reference/SFORB.solution.html b/docs/dev/reference/SFORB.solution.html
index 807fbe5c..e3e43557 100644
--- a/docs/dev/reference/SFORB.solution.html
+++ b/docs/dev/reference/SFORB.solution.html
@@ -1,71 +1,16 @@
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-
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-<meta property="og:description" content="Function describing the solution of the differential equations describing
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 the kinetic model with first-order terms for a two-way transfer from a free
 to a bound fraction, and a first-order degradation term for the free
 fraction.  The initial condition is a defined amount in the free fraction
-and no substance in the bound fraction." />
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+and no substance in the bound fraction."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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 <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]-->
-
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+<![endif]--></head><body data-spy="scroll" data-target="#toc">
+    
 
-  </head>
-
-  <body data-spy="scroll" data-target="#toc">
     <div class="container template-reference-topic">
-      <header>
-      <div class="navbar navbar-default navbar-fixed-top" role="navigation">
+      <header><div class="navbar navbar-default navbar-fixed-top" role="navigation">
   <div class="container">
     <div class="navbar-header">
       <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false">
@@ -76,23 +21,21 @@ and no substance in the bound fraction." />
       </button>
       <span class="navbar-brand">
         <a class="navbar-link" href="../index.html">mkin</a>
-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
       </span>
     </div>
 
     <div id="navbar" class="navbar-collapse collapse">
-      <ul class="nav navbar-nav">
-        <li>
+      <ul class="nav navbar-nav"><li>
   <a href="../reference/index.html">Functions and data</a>
 </li>
 <li class="dropdown">
-  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
+  <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false">
     Articles
      
     <span class="caret"></span>
   </a>
-  <ul class="dropdown-menu" role="menu">
-    <li>
+  <ul class="dropdown-menu" role="menu"><li>
       <a href="../articles/mkin.html">Introduction to mkin</a>
     </li>
     <li>
@@ -102,12 +45,18 @@ and no substance in the bound fraction." />
       <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a>
     </li>
     <li>
-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
     </li>
     <li>
       <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a>
     </li>
     <li>
+      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+    </li>
+    <li>
       <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
     </li>
     <li>
@@ -116,34 +65,27 @@ and no substance in the bound fraction." />
     <li>
       <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a>
     </li>
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+  </ul></li>
 <li>
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 </li>
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+      </ul><ul class="nav navbar-nav navbar-right"><li>
+  <a href="https://github.com/jranke/mkin/" class="external-link">
     <span class="fab fa-github fa-lg"></span>
      
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 </li>
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-      
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+      </ul></div><!--/.nav-collapse -->
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 </div><!--/.navbar -->
 
       
 
-      </header>
-
-<div class="row">
+      </header><div class="row">
   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>Single First-Order Reversible Binding kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>SFORB.solution.Rd</code></div>
     </div>
 
@@ -155,90 +97,93 @@ fraction.  The initial condition is a defined amount in the free fraction
 and no substance in the bound fraction.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>SFORB.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k_12</span>, <span class='va'>k_21</span>, <span class='va'>k_1output</span><span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>k_12</th>
-      <td><p>Kinetic constant describing transfer from free to bound.</p></td>
-    </tr>
-    <tr>
-      <th>k_21</th>
-      <td><p>Kinetic constant describing transfer from bound to free.</p></td>
-    </tr>
-    <tr>
-      <th>k_1output</th>
-      <td><p>Kinetic constant describing degradation of the free
-fraction.</p></td>
-    </tr>
-    </table>
-
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
-
-    <p>The value of the response variable, which is the sum of free and
-bound fractions at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k_12</span>, <span class="va">k_21</span>, <span class="va">k_1output</span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
+
+
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
+
+
+<dt>k_12</dt>
+<dd><p>Kinetic constant describing transfer from free to bound.</p></dd>
+
 
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+<dt>k_21</dt>
+<dd><p>Kinetic constant describing transfer from bound to free.</p></dd>
+
+
+<dt>k_1output</dt>
+<dd><p>Kinetic constant describing degradation of the free
+fraction.</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable, which is the sum of free and
+bound fractions at time <code>t</code>.</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
-FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
+FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>SFORB.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.5</span>, <span class='fl'>2</span>, <span class='fl'>3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span><span class='op'>)</span>
-</div><div class='img'><img src='SFORB.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-</div></pre>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div>
+    </div>
+
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.5</span>, <span class="fl">2</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="SFORB.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
-    </nav>
-  </div>
+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
 </div>
 
 
-      <footer>
-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
 </div>
 
 <div class="pkgdown">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
+  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
 </div>
 
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+      </footer></div>
 
   
 
 
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+  
 
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diff --git a/docs/dev/reference/endpoints.html b/docs/dev/reference/endpoints.html
index ed72ec47..e8198521 100644
--- a/docs/dev/reference/endpoints.html
+++ b/docs/dev/reference/endpoints.html
@@ -23,7 +23,7 @@ advantage that the SFORB model can also be used for metabolites."><meta name="ro
       </button>
       <span class="navbar-brand">
         <a class="navbar-link" href="../index.html">mkin</a>
-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.1.2</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
       </span>
     </div>
 
@@ -50,12 +50,15 @@ advantage that the SFORB model can also be used for metabolites."><meta name="ro
       <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
     </li>
     <li>
-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
     </li>
     <li>
       <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a>
     </li>
     <li>
+      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+    </li>
+    <li>
       <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a>
     </li>
     <li>
@@ -104,21 +107,20 @@ advantage that the SFORB model can also be used for metabolites.</p>
     <div id="arguments">
     <h2>Arguments</h2>
     <dl><dt>fit</dt>
-<dd><p>An object of class <a href="mkinfit.html">mkinfit</a>, <a href="nlme.mmkin.html">nlme.mmkin</a> or <a href="saem.html">saem.mmkin</a>,
-or another object that has list components
-mkinmod containing an <a href="mkinmod.html">mkinmod</a> degradation model, and two numeric vectors,
-bparms.optim and bparms.fixed, that contain parameter values
-for that model.</p></dd>
+<dd><p>An object of class <a href="mkinfit.html">mkinfit</a>, <a href="nlme.mmkin.html">nlme.mmkin</a> or <a href="saem.html">saem.mmkin</a>, or
+another object that has list components mkinmod containing an <a href="mkinmod.html">mkinmod</a>
+degradation model, and two numeric vectors, bparms.optim and bparms.fixed,
+that contain parameter values for that model.</p></dd>
 
 </dl></div>
     <div id="value">
     <h2>Value</h2>
     
 
-<p>A list with a matrix of dissipation times named distimes,
-and, if applicable, a vector of formation fractions named ff
-and, if the SFORB model was in use, a vector of eigenvalues
-of these SFORB models, equivalent to DFOP rate constants</p>
+<p>A list with a matrix of dissipation times named distimes, and, if
+applicable, a vector of formation fractions named ff and, if the SFORB model
+was in use, a vector of eigenvalues of these SFORB models, equivalent to
+DFOP rate constants</p>
     </div>
     <div id="details">
     <h2>Details</h2>
@@ -158,8 +160,8 @@ HS and DFOP, as well as from Eigenvalues b1 and b2 of any SFORB models</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span>           1 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> $SFORB</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_b1 parent_b2 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> 0.4595574 0.0178488 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_b1 parent_b2  parent_g </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 0.4595574 0.0178488 0.8539454 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> $distimes</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>            DT50     DT90 DT50back DT50_parent_b1 DT50_parent_b2</span>
diff --git a/docs/dev/reference/logistic.solution-1.png b/docs/dev/reference/logistic.solution-1.png
index 84d8e722..73dad0a4 100644
--- a/docs/dev/reference/logistic.solution-1.png
+++ b/docs/dev/reference/logistic.solution-1.png
diff --git a/docs/dev/reference/logistic.solution-2.png b/docs/dev/reference/logistic.solution-2.png
index 73e6436d..8d2514a3 100644
--- a/docs/dev/reference/logistic.solution-2.png
+++ b/docs/dev/reference/logistic.solution-2.png
diff --git a/docs/dev/reference/logistic.solution.html b/docs/dev/reference/logistic.solution.html
index ab68c99e..1d1880fd 100644
--- a/docs/dev/reference/logistic.solution.html
+++ b/docs/dev/reference/logistic.solution.html
@@ -1,68 +1,13 @@
-<!-- Generated by pkgdown: do not edit by hand -->
 <!DOCTYPE html>
-<html lang="en">
-  <head>
-  <meta charset="utf-8">
-<meta http-equiv="X-UA-Compatible" content="IE=edge">
-<meta name="viewport" content="width=device-width, initial-scale=1.0">
-
-<title>Logistic kinetics — logistic.solution • mkin</title>
-
-
-<!-- jquery -->
-<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
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+an increasing rate constant, supposedly caused by microbial growth"><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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@@ -73,23 +18,21 @@ an increasing rate constant, supposedly caused by microbial growth" />
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-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
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+      <ul class="nav navbar-nav"><li>
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 </li>
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@@ -99,12 +42,18 @@ an increasing rate constant, supposedly caused by microbial growth" />
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-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
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@@ -113,34 +62,27 @@ an increasing rate constant, supposedly caused by microbial growth" />
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     <div class="page-header">
     <h1>Logistic kinetics</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small>
     <div class="hidden name"><code>logistic.solution.Rd</code></div>
     </div>
 
@@ -149,136 +91,143 @@ an increasing rate constant, supposedly caused by microbial growth" />
 an increasing rate constant, supposedly caused by microbial growth</p>
     </div>
 
-    <pre class="usage"><span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>kmax</span>, <span class='va'>k0</span>, <span class='va'>r</span><span class='op'>)</span></pre>
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">logistic.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">kmax</span>, <span class="va">k0</span>, <span class="va">r</span><span class="op">)</span></span></code></pre></div>
+    </div>
 
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>t</th>
-      <td><p>Time.</p></td>
-    </tr>
-    <tr>
-      <th>parent_0</th>
-      <td><p>Starting value for the response variable at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>kmax</th>
-      <td><p>Maximum rate constant.</p></td>
-    </tr>
-    <tr>
-      <th>k0</th>
-      <td><p>Minimum rate constant effective at time zero.</p></td>
-    </tr>
-    <tr>
-      <th>r</th>
-      <td><p>Growth rate of the increase in the rate constant.</p></td>
-    </tr>
-    </table>
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>t</dt>
+<dd><p>Time.</p></dd>
 
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
 
-    <p>The value of the response variable at time <code>t</code>.</p>
-    <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2>
+<dt>parent_0</dt>
+<dd><p>Starting value for the response variable at time zero.</p></dd>
 
-    <p>The solution of the logistic model reduces to the
-<code><a href='SFO.solution.html'>SFO.solution</a></code> if <code>k0</code> is equal to <code>kmax</code>.</p>
-    <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2>
 
-    <p>FOCUS (2006) &#8220;Guidance Document on Estimating Persistence
+<dt>kmax</dt>
+<dd><p>Maximum rate constant.</p></dd>
+
+
+<dt>k0</dt>
+<dd><p>Minimum rate constant effective at time zero.</p></dd>
+
+
+<dt>r</dt>
+<dd><p>Growth rate of the increase in the rate constant.</p></dd>
+
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
+
+<p>The value of the response variable at time <code>t</code>.</p>
+    </div>
+    <div id="note">
+    <h2>Note</h2>
+    <p>The solution of the logistic model reduces to the
+<code><a href="SFO.solution.html">SFO.solution</a></code> if <code>k0</code> is equal to <code>kmax</code>.</p>
+    </div>
+    <div id="references">
+    <h2>References</h2>
+    <p>FOCUS (2006) “Guidance Document on Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
-FOCUS (2014) &#8220;Generic guidance for Estimating Persistence
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>
+FOCUS (2014) “Generic guidance for Estimating Persistence
 and Degradation Kinetics from Environmental Fate Studies on Pesticides in
-EU Registration&#8221; Report of the FOCUS Work Group on Degradation Kinetics,
+EU Registration” Report of the FOCUS Work Group on Degradation Kinetics,
 Version 1.1, 18 December 2014
-<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
-    <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
-
-    <div class='dont-index'><p>Other parent solutions: 
-<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>,
-<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>,
-<code><a href='HS.solution.html'>HS.solution</a>()</code>,
-<code><a href='IORE.solution.html'>IORE.solution</a>()</code>,
-<code><a href='SFO.solution.html'>SFO.solution</a>()</code>,
-<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code></p></div>
-
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-  <span class='co'># Reproduce the plot on page 57 of FOCUS (2014)</span>
-  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.2</span><span class='op'>)</span>,
-       from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span>,
-       xlab <span class='op'>=</span> <span class='st'>"Time"</span>, ylab <span class='op'>=</span> <span class='st'>"Residue"</span><span class='op'>)</span>
-</div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.4</span><span class='op'>)</span>,
-       from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>2</span>, col <span class='op'>=</span> <span class='fl'>2</span><span class='op'>)</span>
-</div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.8</span><span class='op'>)</span>,
-       from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>3</span>, col <span class='op'>=</span> <span class='fl'>3</span><span class='op'>)</span>
-</div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.001</span>, <span class='fl'>0.2</span><span class='op'>)</span>,
-       from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>4</span>, col <span class='op'>=</span> <span class='fl'>4</span><span class='op'>)</span>
-</div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.08</span>, <span class='fl'>0.2</span><span class='op'>)</span>,
-       from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>5</span>, col <span class='op'>=</span> <span class='fl'>5</span><span class='op'>)</span>
-</div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></span><span class='op'>(</span><span class='st'>"topright"</span>, inset <span class='op'>=</span> <span class='fl'>0.05</span>,
-         legend <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='st'>"k0 = "</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.0001</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.001</span>, <span class='fl'>0.08</span><span class='op'>)</span>,
-                         <span class='st'>", r = "</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.2</span>, <span class='fl'>0.4</span>, <span class='fl'>0.8</span>, <span class='fl'>0.2</span>, <span class='fl'>0.2</span><span class='op'>)</span><span class='op'>)</span>,
-         lty <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span>, col <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span><span class='op'>)</span>
-</div><div class='img'><img src='logistic.solution-1.png' alt='' width='700' height='433' /></div><div class='input'>
-  <span class='co'># Fit with synthetic data</span>
-  <span class='va'>logistic</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"logistic"</span><span class='op'>)</span><span class='op'>)</span>
-
-  <span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span>
-  <span class='va'>parms_logistic</span> <span class='op'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>kmax <span class='op'>=</span> <span class='fl'>0.08</span>, k0 <span class='op'>=</span> <span class='fl'>0.0001</span>, r <span class='op'>=</span> <span class='fl'>0.2</span><span class='op'>)</span>
-  <span class='va'>d_logistic</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>logistic</span>,
-    <span class='va'>parms_logistic</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>,
-    <span class='va'>sampling_times</span><span class='op'>)</span>
-  <span class='va'>d_2_1</span> <span class='op'>&lt;-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_logistic</span>,
-    sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'><a href='sigma_twocomp.html'>sigma_twocomp</a></span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>0.5</span>, <span class='fl'>0.07</span><span class='op'>)</span>,
-    n <span class='op'>=</span> <span class='fl'>1</span>, reps <span class='op'>=</span> <span class='fl'>2</span>, digits <span class='op'>=</span> <span class='fl'>5</span>, LOD <span class='op'>=</span> <span class='fl'>0.1</span>, seed <span class='op'>=</span> <span class='fl'>123456</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span>
+<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p>
+    </div>
+    <div id="see-also">
+    <h2>See also</h2>
+    <div class="dont-index"><p>Other parent solutions: 
+<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>,
+<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>,
+<code><a href="HS.solution.html">HS.solution</a>()</code>,
+<code><a href="IORE.solution.html">IORE.solution</a>()</code>,
+<code><a href="SFO.solution.html">SFO.solution</a>()</code>,
+<code><a href="SFORB.solution.html">SFORB.solution</a>()</code></p></div>
+    </div>
 
-  <span class='va'>m</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"logistic"</span>, <span class='va'>d_2_1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-  <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span>
-</div><div class='img'><img src='logistic.solution-2.png' alt='' width='700' height='433' /></div><div class='input'>  <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span>
-</div><div class='output co'>#&gt;              Estimate   se_notrans   t value       Pr(&gt;t)        Lower
-#&gt; parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02
-#&gt; kmax     6.398190e-02 0.0143201029  4.467978 3.841828e-04 3.929235e-02
-#&gt; k0       1.612775e-04 0.0005866813  0.274898 3.940351e-01 5.846688e-08
-#&gt; r        2.263946e-01 0.1718110662  1.317695 1.061043e-01 4.335843e-02
-#&gt; sigma    5.332935e+00 0.9145907310  5.830952 4.036926e-05 3.340213e+00
-#&gt;                Upper
-#&gt; parent_0 109.9341588
-#&gt; kmax       0.1041853
-#&gt; k0         0.4448749
-#&gt; r          1.1821120
-#&gt; sigma      7.3256566</div><div class='input'>  <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span>
-</div><div class='output co'>#&gt;            DT50     DT90  DT50_k0 DT50_kmax
-#&gt; parent 36.86533 62.41511 4297.853  10.83349</div><div class='input'>
-</div></pre>
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="co"># Reproduce the plot on page 57 of FOCUS (2014)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       xlab <span class="op">=</span> <span class="st">"Time"</span>, ylab <span class="op">=</span> <span class="st">"Residue"</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.4</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">2</span>, col <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.8</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">3</span>, col <span class="op">=</span> <span class="fl">3</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">4</span>, col <span class="op">=</span> <span class="fl">4</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.08</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>       from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">5</span>, col <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></span><span class="op">(</span><span class="st">"topright"</span>, inset <span class="op">=</span> <span class="fl">0.05</span>,</span></span>
+<span class="r-in"><span>         legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"k0 = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.001</span>, <span class="fl">0.08</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>                         <span class="st">", r = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.2</span>, <span class="fl">0.4</span>, <span class="fl">0.8</span>, <span class="fl">0.2</span>, <span class="fl">0.2</span><span class="op">)</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>         lty <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, col <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="logistic.solution-1.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="co"># Fit with synthetic data</span></span></span>
+<span class="r-in"><span>  <span class="va">logistic</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"logistic"</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="va">parms_logistic</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>kmax <span class="op">=</span> <span class="fl">0.08</span>, k0 <span class="op">=</span> <span class="fl">0.0001</span>, r <span class="op">=</span> <span class="fl">0.2</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="va">d_logistic</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">logistic</span>,</span></span>
+<span class="r-in"><span>    <span class="va">parms_logistic</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>    <span class="va">sampling_times</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="va">d_2_1</span> <span class="op">&lt;-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_logistic</span>,</span></span>
+<span class="r-in"><span>    sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="sigma_twocomp.html">sigma_twocomp</a></span><span class="op">(</span><span class="va">x</span>, <span class="fl">0.5</span>, <span class="fl">0.07</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>    n <span class="op">=</span> <span class="fl">1</span>, reps <span class="op">=</span> <span class="fl">2</span>, digits <span class="op">=</span> <span class="fl">5</span>, LOD <span class="op">=</span> <span class="fl">0.1</span>, seed <span class="op">=</span> <span class="fl">123456</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span>  <span class="va">m</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"logistic"</span>, <span class="va">d_2_1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span></span></span>
+<span class="r-plt img"><img src="logistic.solution-2.png" alt="" width="700" height="433"></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>              Estimate   se_notrans   t value       Pr(&gt;t)        Lower</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> kmax     6.398190e-02 0.0143201029  4.467978 3.841828e-04 3.929235e-02</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> k0       1.612775e-04 0.0005866813  0.274898 3.940351e-01 5.846688e-08</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> r        2.263946e-01 0.1718110662  1.317695 1.061043e-01 4.335843e-02</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> sigma    5.332935e+00 0.9145907310  5.830952 4.036926e-05 3.340213e+00</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>                Upper</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0 109.9341588</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> kmax       0.1041853</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> k0         0.4448749</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> r          1.1821120</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> sigma      7.3256566</span>
+<span class="r-in"><span>  <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>            DT50     DT90  DT50_k0 DT50_kmax</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent 36.86533 62.41511 4297.853  10.83349</span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
-    </nav>
-  </div>
+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
 </div>
 
 
-      <footer>
-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
 </div>
 
 <div class="pkgdown">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
+  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
 </div>
 
-      </footer>
-   </div>
+      </footer></div>
 
   
 
 
-  </body>
-</html>
+  
 
+  </body></html>
 
diff --git a/docs/dev/reference/mhmkin.html b/docs/dev/reference/mhmkin.html
index cbfeae60..e87e20a1 100644
--- a/docs/dev/reference/mhmkin.html
+++ b/docs/dev/reference/mhmkin.html
@@ -99,7 +99,7 @@ mixed-effects model fitting functions.</p>
     </div>
 
     <div id="ref-usage">
-    <div class="sourceCode"><pre><code>mhmkin(objects, backend = "saemix", algorithm = "saem", ...)
+    <div class="sourceCode"><pre><code>mhmkin(objects, ...)
 
 # S3 method for mmkin
 mhmkin(objects, ...)
@@ -108,6 +108,9 @@ mhmkin(objects, ...)
 mhmkin(
   objects,
   backend = "saemix",
+  algorithm = "saem",
+  no_random_effect = NULL,
+  auto_ranef_threshold = 3,
   ...,
   cores = if (Sys.info()["sysname"] == "Windows") 1 else parallel::detectCores(),
   cluster = NULL
@@ -129,6 +132,11 @@ Alternatively, a single <a href="mmkin.html">mmkin</a> object containing fits of
 degradation models to the same data</p></dd>
 
 
+<dt>...</dt>
+<dd><p>Further arguments that will be passed to the nonlinear mixed-effects
+model fitting function.</p></dd>
+
+
 <dt>backend</dt>
 <dd><p>The backend to be used for fitting. Currently, only saemix is
 supported</p></dd>
@@ -138,9 +146,17 @@ supported</p></dd>
 <dd><p>The algorithm to be used for fitting (currently not used)</p></dd>
 
 
-<dt>...</dt>
-<dd><p>Further arguments that will be passed to the nonlinear mixed-effects
-model fitting function.</p></dd>
+<dt>no_random_effect</dt>
+<dd><p>Default is NULL and will be passed to <a href="saem.html">saem</a>. If
+you specify "auto", random effects are only included if the number
+of datasets in which the parameter passed the t-test is at least 'auto_ranef_threshold'.
+Beware that while this may make for convenient model reduction or even
+numerical stability of the algorithm, it will likely lead to
+underparameterised models.</p></dd>
+
+
+<dt>auto_ranef_threshold</dt>
+<dd><p>See 'no_random_effect.</p></dd>
 
 
 <dt>cores</dt>
diff --git a/docs/dev/reference/mkinpredict.html b/docs/dev/reference/mkinpredict.html
index 1ebaecb5..14f2b75b 100644
--- a/docs/dev/reference/mkinpredict.html
+++ b/docs/dev/reference/mkinpredict.html
@@ -1,69 +1,14 @@
-<!-- Generated by pkgdown: do not edit by hand -->
 <!DOCTYPE html>
-<html lang="en">
-  <head>
-  <meta charset="utf-8">
-<meta http-equiv="X-UA-Compatible" content="IE=edge">
-<meta name="viewport" content="width=device-width, initial-scale=1.0">
-
-<title>Produce predictions from a kinetic model using specific parameters — mkinpredict • mkin</title>
-
-
-<!-- jquery -->
-<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
-<!-- Bootstrap -->
-
-<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" />
-
-<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script>
-
-<!-- bootstrap-toc -->
-<link rel="stylesheet" href="../bootstrap-toc.css">
-<script src="../bootstrap-toc.js"></script>
-
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-kinetic parameters and initial values for the state variables." />
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@@ -74,23 +19,21 @@ kinetic parameters and initial values for the state variables." />
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-        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.0.3.9000</span>
+        <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.0</span>
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@@ -100,12 +43,18 @@ kinetic parameters and initial values for the state variables." />
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-      <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a>
+      <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a>
+    </li>
+    <li>
+      <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a>
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+    <li>
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@@ -114,343 +63,358 @@ kinetic parameters and initial values for the state variables." />
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   <div class="col-md-9 contents">
     <div class="page-header">
     <h1>Produce predictions from a kinetic model using specific parameters</h1>
-    <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinpredict.R'><code>R/mkinpredict.R</code></a></small>
+    <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinpredict.R" class="external-link"><code>R/mkinpredict.R</code></a></small>
     <div class="hidden name"><code>mkinpredict.Rd</code></div>
     </div>
 
     <div class="ref-description">
     <p>This function produces a time series for all the observed variables in a
-kinetic model as specified by <code><a href='mkinmod.html'>mkinmod</a></code>, using a specific set of
+kinetic model as specified by <a href="mkinmod.html">mkinmod</a>, using a specific set of
 kinetic parameters and initial values for the state variables.</p>
     </div>
 
-    <pre class="usage"><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>x</span>, <span class='va'>odeparms</span>, <span class='va'>odeini</span>, <span class='va'>outtimes</span>, <span class='va'>...</span><span class='op'>)</span>
-
-<span class='co'># S3 method for mkinmod</span>
-<span class='fu'>mkinpredict</span><span class='op'>(</span>
-  <span class='va'>x</span>,
-  odeparms <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent_sink <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-  odeini <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>,
-  outtimes <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>120</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-  solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>,
-  use_compiled <span class='op'>=</span> <span class='st'>"auto"</span>,
-  method.ode <span class='op'>=</span> <span class='st'>"lsoda"</span>,
-  atol <span class='op'>=</span> <span class='fl'>1e-08</span>,
-  rtol <span class='op'>=</span> <span class='fl'>1e-10</span>,
-  map_output <span class='op'>=</span> <span class='cn'>TRUE</span>,
-  na_stop <span class='op'>=</span> <span class='cn'>TRUE</span>,
-  <span class='va'>...</span>
-<span class='op'>)</span>
-
-<span class='co'># S3 method for mkinfit</span>
-<span class='fu'>mkinpredict</span><span class='op'>(</span>
-  <span class='va'>x</span>,
-  odeparms <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>bparms.ode</span>,
-  odeini <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>bparms.state</span>,
-  outtimes <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>120</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-  solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>,
-  use_compiled <span class='op'>=</span> <span class='st'>"auto"</span>,
-  method.ode <span class='op'>=</span> <span class='st'>"lsoda"</span>,
-  atol <span class='op'>=</span> <span class='fl'>1e-08</span>,
-  rtol <span class='op'>=</span> <span class='fl'>1e-10</span>,
-  map_output <span class='op'>=</span> <span class='cn'>TRUE</span>,
-  <span class='va'>...</span>
-<span class='op'>)</span></pre>
-
-    <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
-    <table class="ref-arguments">
-    <colgroup><col class="name" /><col class="desc" /></colgroup>
-    <tr>
-      <th>x</th>
-      <td><p>A kinetic model as produced by <code><a href='mkinmod.html'>mkinmod</a></code>, or a kinetic
-fit as fitted by <code><a href='mkinfit.html'>mkinfit</a></code>. In the latter case, the fitted
-parameters are used for the prediction.</p></td>
-    </tr>
-    <tr>
-      <th>odeparms</th>
-      <td><p>A numeric vector specifying the parameters used in the
-kinetic model, which is generally defined as a set of ordinary
-differential equations.</p></td>
-    </tr>
-    <tr>
-      <th>odeini</th>
-      <td><p>A numeric vector containing the initial values of the state
+    <div id="ref-usage">
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">x</span>, <span class="va">odeparms</span>, <span class="va">odeini</span>, <span class="va">outtimes</span>, <span class="va">...</span><span class="op">)</span></span>
+<span></span>
+<span><span class="co"># S3 method for mkinmod</span></span>
+<span><span class="fu">mkinpredict</span><span class="op">(</span></span>
+<span>  <span class="va">x</span>,</span>
+<span>  odeparms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent_sink <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span>
+<span>  odeini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span>
+<span>  outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span>
+<span>  solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span>
+<span>  use_compiled <span class="op">=</span> <span class="st">"auto"</span>,</span>
+<span>  method.ode <span class="op">=</span> <span class="st">"lsoda"</span>,</span>
+<span>  atol <span class="op">=</span> <span class="fl">1e-08</span>,</span>
+<span>  rtol <span class="op">=</span> <span class="fl">1e-10</span>,</span>
+<span>  maxsteps <span class="op">=</span> <span class="fl">20000</span>,</span>
+<span>  map_output <span class="op">=</span> <span class="cn">TRUE</span>,</span>
+<span>  na_stop <span class="op">=</span> <span class="cn">TRUE</span>,</span>
+<span>  <span class="va">...</span></span>
+<span><span class="op">)</span></span>
+<span></span>
+<span><span class="co"># S3 method for mkinfit</span></span>
+<span><span class="fu">mkinpredict</span><span class="op">(</span></span>
+<span>  <span class="va">x</span>,</span>
+<span>  odeparms <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.ode</span>,</span>
+<span>  odeini <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.state</span>,</span>
+<span>  outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span>
+<span>  solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span>
+<span>  use_compiled <span class="op">=</span> <span class="st">"auto"</span>,</span>
+<span>  method.ode <span class="op">=</span> <span class="st">"lsoda"</span>,</span>
+<span>  atol <span class="op">=</span> <span class="fl">1e-08</span>,</span>
+<span>  rtol <span class="op">=</span> <span class="fl">1e-10</span>,</span>
+<span>  map_output <span class="op">=</span> <span class="cn">TRUE</span>,</span>
+<span>  <span class="va">...</span></span>
+<span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div id="arguments">
+    <h2>Arguments</h2>
+    <dl><dt>x</dt>
+<dd><p>A kinetic model as produced by <a href="mkinmod.html">mkinmod</a>, or a kinetic fit as
+fitted by <a href="mkinfit.html">mkinfit</a>. In the latter case, the fitted parameters are used for
+the prediction.</p></dd>
+
+
+<dt>odeparms</dt>
+<dd><p>A numeric vector specifying the parameters used in the
+kinetic model, which is generally defined as a set of ordinary differential
+equations.</p></dd>
+
+
+<dt>odeini</dt>
+<dd><p>A numeric vector containing the initial values of the state
 variables of the model. Note that the state variables can differ from the
-observed variables, for example in the case of the SFORB model.</p></td>
-    </tr>
-    <tr>
-      <th>outtimes</th>
-      <td><p>A numeric vector specifying the time points for which model
-predictions should be generated.</p></td>
-    </tr>
-    <tr>
-      <th>...</th>
-      <td><p>Further arguments passed to the ode solver in case such a
-solver is used.</p></td>
-    </tr>
-    <tr>
-      <th>solution_type</th>
-      <td><p>The method that should be used for producing the
+observed variables, for example in the case of the SFORB model.</p></dd>
+
+
+<dt>outtimes</dt>
+<dd><p>A numeric vector specifying the time points for which model
+predictions should be generated.</p></dd>
+
+
+<dt>...</dt>
+<dd><p>Further arguments passed to the ode solver in case such a
+solver is used.</p></dd>
+
+
+<dt>solution_type</dt>
+<dd><p>The method that should be used for producing the
 predictions. This should generally be "analytical" if there is only one
 observed variable, and usually "deSolve" in the case of several observed
 variables. The third possibility "eigen" is faster but not applicable to
-some models e.g.  using FOMC for the parent compound.</p></td>
-    </tr>
-    <tr>
-      <th>use_compiled</th>
-      <td><p>If set to <code>FALSE</code>, no compiled version of the
-<code><a href='mkinmod.html'>mkinmod</a></code> model is used, even if is present.</p></td>
-    </tr>
-    <tr>
-      <th>method.ode</th>
-      <td><p>The solution method passed via <code>mkinpredict</code>
-to <code>ode</code> in case the solution type is "deSolve". The default
-"lsoda" is performant, but sometimes fails to converge.</p></td>
-    </tr>
-    <tr>
-      <th>atol</th>
-      <td><p>Absolute error tolerance, passed to <code>ode</code>. Default
-is 1e-8, lower than in <code>lsoda</code>.</p></td>
-    </tr>
-    <tr>
-      <th>rtol</th>
-      <td><p>Absolute error tolerance, passed to <code>ode</code>. Default
-is 1e-10, much lower than in <code>lsoda</code>.</p></td>
-    </tr>
-    <tr>
-      <th>map_output</th>
-      <td><p>Boolean to specify if the output should list values for
+some models e.g.  using FOMC for the parent compound.</p></dd>
+
+
+<dt>use_compiled</dt>
+<dd><p>If set to <code>FALSE</code>, no compiled version of the
+<a href="mkinmod.html">mkinmod</a> model is used, even if is present.</p></dd>
+
+
+<dt>method.ode</dt>
+<dd><p>The solution method passed via mkinpredict to ode] in
+case the solution type is "deSolve". The default "lsoda" is performant, but
+sometimes fails to converge.</p></dd>
+
+
+<dt>atol</dt>
+<dd><p>Absolute error tolerance, passed to ode. Default is 1e-8,
+lower than in lsoda.</p></dd>
+
+
+<dt>rtol</dt>
+<dd><p>Absolute error tolerance, passed to ode. Default is 1e-10,
+much lower than in lsoda.</p></dd>
+
+
+<dt>maxsteps</dt>
+<dd><p>Maximum number of steps, passed to ode.</p></dd>
+
+
+<dt>map_output</dt>
+<dd><p>Boolean to specify if the output should list values for
 the observed variables (default) or for all state variables (if set to
 FALSE). Setting this to FALSE has no effect for analytical solutions,
-as these always return mapped output.</p></td>
-    </tr>
-    <tr>
-      <th>na_stop</th>
-      <td><p>Should it be an error if deSolve::ode returns NaN values</p></td>
-    </tr>
-    </table>
+as these always return mapped output.</p></dd>
+
 
-    <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
+<dt>na_stop</dt>
+<dd><p>Should it be an error if ode returns NaN values</p></dd>
 
-    <p>A matrix with the numeric solution in wide format</p>
-    <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2>
+</dl></div>
+    <div id="value">
+    <h2>Value</h2>
+    
 
+<p>A matrix with the numeric solution in wide format</p>
+    </div>
+    <div id="author">
+    <h2>Author</h2>
     <p>Johannes Ranke</p>
+    </div>
 
-    <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
-    <pre class="examples"><div class='input'>
-<span class='va'>SFO</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span>
-<span class='co'># Compare solution types</span>
-<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"analytical"</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;    time  degradinol
-#&gt; 0     0 100.0000000
-#&gt; 1     1  74.0818221
-#&gt; 2     2  54.8811636
-#&gt; 3     3  40.6569660
-#&gt; 4     4  30.1194212
-#&gt; 5     5  22.3130160
-#&gt; 6     6  16.5298888
-#&gt; 7     7  12.2456428
-#&gt; 8     8   9.0717953
-#&gt; 9     9   6.7205513
-#&gt; 10   10   4.9787068
-#&gt; 11   11   3.6883167
-#&gt; 12   12   2.7323722
-#&gt; 13   13   2.0241911
-#&gt; 14   14   1.4995577
-#&gt; 15   15   1.1108997
-#&gt; 16   16   0.8229747
-#&gt; 17   17   0.6096747
-#&gt; 18   18   0.4516581
-#&gt; 19   19   0.3345965
-#&gt; 20   20   0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;    time  degradinol
-#&gt; 0     0 100.0000000
-#&gt; 1     1  74.0818221
-#&gt; 2     2  54.8811636
-#&gt; 3     3  40.6569660
-#&gt; 4     4  30.1194212
-#&gt; 5     5  22.3130160
-#&gt; 6     6  16.5298888
-#&gt; 7     7  12.2456428
-#&gt; 8     8   9.0717953
-#&gt; 9     9   6.7205513
-#&gt; 10   10   4.9787068
-#&gt; 11   11   3.6883167
-#&gt; 12   12   2.7323722
-#&gt; 13   13   2.0241911
-#&gt; 14   14   1.4995577
-#&gt; 15   15   1.1108996
-#&gt; 16   16   0.8229747
-#&gt; 17   17   0.6096747
-#&gt; 18   18   0.4516581
-#&gt; 19   19   0.3345965
-#&gt; 20   20   0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;    time  degradinol
-#&gt; 0     0 100.0000000
-#&gt; 1     1  74.0818221
-#&gt; 2     2  54.8811636
-#&gt; 3     3  40.6569660
-#&gt; 4     4  30.1194212
-#&gt; 5     5  22.3130160
-#&gt; 6     6  16.5298888
-#&gt; 7     7  12.2456428
-#&gt; 8     8   9.0717953
-#&gt; 9     9   6.7205513
-#&gt; 10   10   4.9787068
-#&gt; 11   11   3.6883167
-#&gt; 12   12   2.7323722
-#&gt; 13   13   2.0241911
-#&gt; 14   14   1.4995577
-#&gt; 15   15   1.1108996
-#&gt; 16   16   0.8229747
-#&gt; 17   17   0.6096747
-#&gt; 18   18   0.4516581
-#&gt; 19   19   0.3345965
-#&gt; 20   20   0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"eigen"</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;    time  degradinol
-#&gt; 0     0 100.0000000
-#&gt; 1     1  74.0818221
-#&gt; 2     2  54.8811636
-#&gt; 3     3  40.6569660
-#&gt; 4     4  30.1194212
-#&gt; 5     5  22.3130160
-#&gt; 6     6  16.5298888
-#&gt; 7     7  12.2456428
-#&gt; 8     8   9.0717953
-#&gt; 9     9   6.7205513
-#&gt; 10   10   4.9787068
-#&gt; 11   11   3.6883167
-#&gt; 12   12   2.7323722
-#&gt; 13   13   2.0241911
-#&gt; 14   14   1.4995577
-#&gt; 15   15   1.1108997
-#&gt; 16   16   0.8229747
-#&gt; 17   17   0.6096747
-#&gt; 18   18   0.4516581
-#&gt; 19   19   0.3345965
-#&gt; 20   20   0.2478752</div><div class='input'>
-<span class='co'># Compare integration methods to analytical solution</span>
-<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"analytical"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      method <span class='op'>=</span> <span class='st'>"lsoda"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      method <span class='op'>=</span> <span class='st'>"ode45"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>,
-      method <span class='op'>=</span> <span class='st'>"rk4"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2480043 </div><div class='input'><span class='co'># rk4 is not as precise here</span>
-
-<span class='co'># The number of output times used to make a lot of difference until the</span>
-<span class='co'># default for atol was adjusted</span>
-<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>2001</span>,<span class='op'>]</span>
-</div><div class='output co'>#&gt;       time degradinol 
-#&gt; 20.0000000  0.2478752 </div><div class='input'>
-<span class='co'># Comparison of the performance of solution types</span>
-<span class='va'>SFO_SFO</span> <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span>,
-                  m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span>
-</div><div class='output co'>#&gt; <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='kw'>if</span><span class='op'>(</span><span class='kw'><a href='https://rdrr.io/r/base/library.html'>require</a></span><span class='op'>(</span><span class='va'><a href='http://rbenchmark.googlecode.com'>rbenchmark</a></span><span class='op'>)</span><span class='op'>)</span> <span class='op'>{</span>
-  <span class='fu'><a href='https://rdrr.io/pkg/rbenchmark/man/benchmark.html'>benchmark</a></span><span class='op'>(</span>replications <span class='op'>=</span> <span class='fl'>10</span>, order <span class='op'>=</span> <span class='st'>"relative"</span>, columns <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"test"</span>, <span class='st'>"relative"</span>, <span class='st'>"elapsed"</span><span class='op'>)</span>,
-    eigen <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"eigen"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>,
-    deSolve_compiled <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>,
-    deSolve <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>,
-    analytical <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>,
-      <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>,
-      solution_type <span class='op'>=</span> <span class='st'>"analytical"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span><span class='op'>)</span>
-<span class='op'>}</span>
-</div><div class='output co'>#&gt;               test relative elapsed
-#&gt; 2 deSolve_compiled      1.0   0.005
-#&gt; 4       analytical      1.0   0.005
-#&gt; 1            eigen      4.4   0.022
-#&gt; 3          deSolve     46.8   0.234</div><div class='input'>
-<span class='co'># \dontrun{</span>
-  <span class='co'># Predict from a fitted model</span>
-  <span class='va'>f</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>
-  <span class='va'>f</span> <span class='op'>&lt;-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span>
-  <span class='fu'><a href='https://rdrr.io/r/utils/head.html'>head</a></span><span class='op'>(</span><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span><span class='op'>)</span>
-</div><div class='output co'>#&gt;     time   parent       m1
-#&gt; 0    0.0 82.49216 0.000000
-#&gt; 0.1  0.1 80.00562 1.236394
-#&gt; 0.2  0.2 77.59404 2.423201
-#&gt; 0.3  0.3 75.25514 3.562040
-#&gt; 0.4  0.4 72.98675 4.654478
-#&gt; 0.5  0.5 70.78673 5.702033</div><div class='input'><span class='co'># }</span>
-
-</div></pre>
+    <div id="ref-examples">
+    <h2>Examples</h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="va">SFO</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-in"><span><span class="co"># Compare solution types</span></span></span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    time  degradinol</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 0     0 100.0000000</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1     1  74.0818221</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2     2  54.8811636</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3     3  40.6569660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 4     4  30.1194212</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 5     5  22.3130160</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 6     6  16.5298888</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 7     7  12.2456428</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 8     8   9.0717953</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 9     9   6.7205513</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 10   10   4.9787068</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 11   11   3.6883167</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 12   12   2.7323722</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 13   13   2.0241911</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 14   14   1.4995577</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 15   15   1.1108997</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 16   16   0.8229747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 17   17   0.6096747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 18   18   0.4516581</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 19   19   0.3345965</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20   20   0.2478752</span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    time  degradinol</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 0     0 100.0000000</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1     1  74.0818221</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2     2  54.8811636</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3     3  40.6569660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 4     4  30.1194212</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 5     5  22.3130160</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 6     6  16.5298888</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 7     7  12.2456428</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 8     8   9.0717953</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 9     9   6.7205513</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 10   10   4.9787068</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 11   11   3.6883167</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 12   12   2.7323722</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 13   13   2.0241911</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 14   14   1.4995577</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 15   15   1.1108996</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 16   16   0.8229747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 17   17   0.6096747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 18   18   0.4516581</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 19   19   0.3345965</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20   20   0.2478752</span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    time  degradinol</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 0     0 100.0000000</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1     1  74.0818221</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2     2  54.8811636</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3     3  40.6569660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 4     4  30.1194212</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 5     5  22.3130160</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 6     6  16.5298888</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 7     7  12.2456428</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 8     8   9.0717953</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 9     9   6.7205513</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 10   10   4.9787068</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 11   11   3.6883167</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 12   12   2.7323722</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 13   13   2.0241911</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 14   14   1.4995577</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 15   15   1.1108996</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 16   16   0.8229747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 17   17   0.6096747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 18   18   0.4516581</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 19   19   0.3345965</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20   20   0.2478752</span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    time  degradinol</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 0     0 100.0000000</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1     1  74.0818221</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2     2  54.8811636</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3     3  40.6569660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 4     4  30.1194212</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 5     5  22.3130160</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 6     6  16.5298888</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 7     7  12.2456428</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 8     8   9.0717953</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 9     9   6.7205513</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 10   10   4.9787068</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 11   11   3.6883167</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 12   12   2.7323722</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 13   13   2.0241911</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 14   14   1.4995577</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 15   15   1.1108997</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 16   16   0.8229747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 17   17   0.6096747</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 18   18   0.4516581</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 19   19   0.3345965</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20   20   0.2478752</span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="co"># Compare integration methods to analytical solution</span></span></span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2478752 </span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      method <span class="op">=</span> <span class="st">"lsoda"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2478752 </span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      method <span class="op">=</span> <span class="st">"ode45"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2478752 </span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span>
+<span class="r-in"><span>      method <span class="op">=</span> <span class="st">"rk4"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2480043 </span>
+<span class="r-in"><span><span class="co"># rk4 is not as precise here</span></span></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="co"># The number of output times used to make a lot of difference until the</span></span></span>
+<span class="r-in"><span><span class="co"># default for atol was adjusted</span></span></span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2478752 </span>
+<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">2001</span>,<span class="op">]</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       time degradinol </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 20.0000000  0.2478752 </span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="co"># Comparison of the performance of solution types</span></span></span>
+<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>                  m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span>
+<span class="r-msg co"><span class="r-pr">#&gt;</span> Temporary DLL for differentials generated and loaded</span>
+<span class="r-in"><span><span class="kw">if</span><span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span>replications <span class="op">=</span> <span class="fl">10</span>, order <span class="op">=</span> <span class="st">"relative"</span>, columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>    eigen <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span>
+<span class="r-in"><span>    deSolve_compiled <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span>
+<span class="r-in"><span>    deSolve <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span>
+<span class="r-in"><span>    analytical <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span>
+<span class="r-in"><span>      solution_type <span class="op">=</span> <span class="st">"analytical"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span><span class="op">)</span></span></span>
+<span class="r-in"><span><span class="op">}</span></span></span>
+<span class="r-msg co"><span class="r-pr">#&gt;</span> Loading required package: rbenchmark</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>               test relative elapsed</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2 deSolve_compiled     1.00   0.004</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 4       analytical     5.25   0.021</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1            eigen     6.00   0.024</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3          deSolve    52.50   0.210</span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="co"># \dontrun{</span></span></span>
+<span class="r-in"><span>  <span class="co"># Predict from a fitted model</span></span></span>
+<span class="r-in"><span>  <span class="va">f</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="va">f</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span>
+<span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">f</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> DLSODA-  At current T (=R1), MXSTEP (=I1) steps   </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>       taken on this call before reaching TOUT     </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> In above message, I1 = 1</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> In above message, R1 = 9.99904e-07</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  </span>
+<span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>an excessive amount of work (&gt; maxsteps ) was done, but integration was not successful - increase maxsteps</span>
+<span class="r-wrn co"><span class="r-pr">#&gt;</span> <span class="warning">Warning: </span>Returning early. Results are accurate, as far as they go</span>
+<span class="r-err co"><span class="r-pr">#&gt;</span> <span class="error">Error in out[available, var]:</span> (subscript) logical subscript too long</span>
+<span class="r-in"><span><span class="co"># }</span></span></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
   </div>
   <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
-    <nav id="toc" data-toggle="toc" class="sticky-top">
-      <h2 data-toc-skip>Contents</h2>
-    </nav>
-  </div>
+    <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2>
+    </nav></div>
 </div>
 
 
-      <footer>
-      <div class="copyright">
-  <p>Developed by Johannes Ranke.</p>
+      <footer><div class="copyright">
+  <p></p><p>Developed by Johannes Ranke.</p>
 </div>
 
 <div class="pkgdown">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
+  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p>
 </div>
 
-      </footer>
-   </div>
+      </footer></div>
 
   
 
 
-  </body>
-</html>
+  
 
+  </body></html>
 
diff --git a/docs/dev/reference/saem-1.png b/docs/dev/reference/saem-1.png
index 08939d4f..9e310252 100644
--- a/docs/dev/reference/saem-1.png
+++ b/docs/dev/reference/saem-1.png
diff --git a/docs/dev/reference/saem-2.png b/docs/dev/reference/saem-2.png
index b737db03..de1bcf57 100644
--- a/docs/dev/reference/saem-2.png
+++ b/docs/dev/reference/saem-2.png
diff --git a/docs/dev/reference/saem-3.png b/docs/dev/reference/saem-3.png
index 08e0f544..de569ce0 100644
--- a/docs/dev/reference/saem-3.png
+++ b/docs/dev/reference/saem-3.png
diff --git a/docs/dev/reference/saem-4.png b/docs/dev/reference/saem-4.png
index bb775c25..0f2ee3e7 100644
--- a/docs/dev/reference/saem-4.png
+++ b/docs/dev/reference/saem-4.png
diff --git a/docs/dev/reference/saem.html b/docs/dev/reference/saem.html
index 8ea0ef6e..968dc68c 100644
--- a/docs/dev/reference/saem.html
+++ b/docs/dev/reference/saem.html
@@ -106,13 +106,14 @@ Expectation Maximisation algorithm (SAEM).</p>
 <span>  conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span>
 <span>  solution_type <span class="op">=</span> <span class="st">"auto"</span>,</span>
 <span>  covariance.model <span class="op">=</span> <span class="st">"auto"</span>,</span>
+<span>  omega.init <span class="op">=</span> <span class="st">"auto"</span>,</span>
 <span>  covariates <span class="op">=</span> <span class="cn">NULL</span>,</span>
 <span>  covariate_models <span class="op">=</span> <span class="cn">NULL</span>,</span>
 <span>  no_random_effect <span class="op">=</span> <span class="cn">NULL</span>,</span>
+<span>  error.init <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fl">0.1</span><span class="op">)</span>,</span>
 <span>  nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">300</span>, <span class="fl">100</span><span class="op">)</span>,</span>
 <span>  control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>displayProgress <span class="op">=</span> <span class="cn">FALSE</span>, print <span class="op">=</span> <span class="cn">FALSE</span>, nbiter.saemix <span class="op">=</span> <span class="va">nbiter.saemix</span>,</span>
 <span>    save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span>
-<span>  fail_with_errors <span class="op">=</span> <span class="cn">TRUE</span>,</span>
 <span>  verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span>
 <span>  quiet <span class="op">=</span> <span class="cn">FALSE</span>,</span>
 <span>  <span class="va">...</span></span>
@@ -129,8 +130,10 @@ Expectation Maximisation algorithm (SAEM).</p>
 <span>  degparms_start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>,</span>
 <span>  covariance.model <span class="op">=</span> <span class="st">"auto"</span>,</span>
 <span>  no_random_effect <span class="op">=</span> <span class="cn">NULL</span>,</span>
+<span>  omega.init <span class="op">=</span> <span class="st">"auto"</span>,</span>
 <span>  covariates <span class="op">=</span> <span class="cn">NULL</span>,</span>
 <span>  covariate_models <span class="op">=</span> <span class="cn">NULL</span>,</span>
+<span>  error.init <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>,</span>
 <span>  test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>,</span>
 <span>  conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span>
 <span>  verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span>
@@ -189,11 +192,21 @@ automatic choice is not desired</p></dd>
 
 
 <dt>covariance.model</dt>
-<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel()</a></code>. Per
+<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>. Per
 default, uncorrelated random effects are specified for all degradation
 parameters.</p></dd>
 
 
+<dt>omega.init</dt>
+<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>. If using
+mkin transformations and the default covariance model with optionally
+excluded random effects, the variances of the degradation parameters
+are estimated using <a href="mean_degparms.html">mean_degparms</a>, with testing of untransformed
+log parameters for significant difference from zero. If not using
+mkin transformations or a custom covariance model, the default
+initialisation of <a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel</a> is used for omega.init.</p></dd>
+
+
 <dt>covariates</dt>
 <dd><p>A data frame with covariate data for use in
 'covariate_models', with dataset names as row names.</p></dd>
@@ -211,6 +224,10 @@ which there should be no variability over the groups. Only used
 if the covariance model is not explicitly specified.</p></dd>
 
 
+<dt>error.init</dt>
+<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>.</p></dd>
+
+
 <dt>nbiter.saemix</dt>
 <dd><p>Convenience option to increase the number of
 iterations</p></dd>
@@ -220,11 +237,6 @@ iterations</p></dd>
 <dd><p>Passed to <a href="https://rdrr.io/pkg/saemix/man/saemix.html" class="external-link">saemix::saemix</a>.</p></dd>
 
 
-<dt>fail_with_errors</dt>
-<dd><p>Should a failure to compute standard errors
-from the inverse of the Fisher Information Matrix be a failure?</p></dd>
-
-
 <dt>verbose</dt>
 <dd><p>Should we print information about created objects of
 type <a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel</a> and <a href="https://rdrr.io/pkg/saemix/man/SaemixData-class.html" class="external-link">saemix::SaemixData</a>?</p></dd>
@@ -293,15 +305,15 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>             npar    AIC    BIC     Lik</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.26 622.31 -307.13</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc    7 467.87 465.13 -226.93</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.98 490.47 -237.99</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.33 622.38 -307.17</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc    7 467.85 465.11 -226.92</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.76 490.24 -237.88</span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_sfo</span>, <span class="va">f_saem_dfop</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>             npar    AIC    BIC     Lik  Chisq Df Pr(&gt;Chisq)    </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.26 622.31 -307.13                         </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.98 490.47 -237.99 138.28  4  &lt; 2.2e-16 ***</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.33 622.38 -307.17                         </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.76 490.24 -237.88 138.57  4  &lt; 2.2e-16 ***</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> ---</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span>
 <span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop</span><span class="op">)</span></span></span>
@@ -311,16 +323,16 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>                 npar    AIC    BIC     Lik Chisq Df Pr(&gt;Chisq)</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop_red    8 490.64 487.52 -237.32                    </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop        9 493.98 490.47 -237.99     0  1          1</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop_red    8 488.68 485.55 -236.34                    </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop        9 493.76 490.24 -237.88     0  1          1</span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_sfo</span>, <span class="va">f_saem_fomc</span>, <span class="va">f_saem_dfop</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>             npar    AIC    BIC     Lik</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.26 622.31 -307.13</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc    7 467.87 465.13 -226.93</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.98 490.47 -237.99</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_sfo     5 624.33 622.38 -307.17</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc    7 467.85 465.11 -226.92</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_dfop    9 493.76 490.24 -237.88</span>
 <span class="r-in"><span><span class="co"># The returned saem.mmkin object contains an SaemixObject, therefore we can use</span></span></span>
 <span class="r-in"><span><span class="co"># functions from saemix</span></span></span>
 <span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span></span>
@@ -335,9 +347,9 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span><span class="va">f_saem_sfo</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_dfop</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span></span>
 <span class="r-msg co"><span class="r-pr">#&gt;</span> Likelihoods calculated by importance sampling</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>        AIC      BIC</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> 1 624.2598 622.3070</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> 2 467.8664 465.1324</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> 3 493.9811 490.4660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 1 624.3316 622.3788</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 2 467.8472 465.1132</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> 3 493.7592 490.2441</span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></span>
 <span class="r-plt img"><img src="saem-1.png" alt="" width="700" height="433"></span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"individual.fit"</span><span class="op">)</span></span></span>
@@ -354,9 +366,9 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_fomc</span>, <span class="va">f_saem_fomc_tc</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>                npar    AIC    BIC     Lik  Chisq Df Pr(&gt;Chisq)</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc       7 467.87 465.13 -226.93                     </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc_tc    8 469.80 466.68 -226.90 0.0645  1     0.7995</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>                npar    AIC    BIC     Lik Chisq Df Pr(&gt;Chisq)</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc       7 467.85 465.11 -226.92                    </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_saem_fomc_tc    8 469.83 466.71 -226.92 0.015  1     0.9027</span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="va">sfo_sfo</span> <span class="op">&lt;-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span>
 <span class="r-in"><span>  A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span>
@@ -393,32 +405,32 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span> 170 observations of 2 variable(s) grouped in 5 datasets</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Likelihood computed by importance sampling</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   AIC   BIC logLik</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   842 836.9   -408</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>     AIC   BIC logLik</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   839.2 834.1 -406.6</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Fitted parameters:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>                    estimate   lower   upper</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0            93.7701 91.1458 96.3945</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1            -5.8116 -7.5998 -4.0234</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis     -0.9608 -1.3654 -0.5562</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1              -2.5841 -3.6876 -1.4805</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2              -3.5228 -5.3254 -1.7203</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis            -0.1027 -0.8719  0.6665</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> a.1                  1.8856  1.6676  2.1037</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0          2.7682  0.7668  4.7695</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1          1.7447  0.4047  3.0848</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis   0.4525  0.1620  0.7431</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1            1.2423  0.4560  2.0285</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2            2.0390  0.7601  3.3180</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis          0.4439 -0.3069  1.1947</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>                    estimate    lower   upper</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0           93.70402 91.04104 96.3670</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1           -5.83760 -7.66452 -4.0107</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis    -0.95718 -1.35955 -0.5548</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1             -2.35514 -3.39402 -1.3163</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2             -3.79634 -5.64009 -1.9526</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis           -0.02108 -0.66463  0.6225</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> a.1                 1.88191  1.66491  2.0989</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0         2.81628  0.78922  4.8433</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1         1.78751  0.42105  3.1540</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis  0.45016  0.16116  0.7391</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1           1.06923  0.31676  1.8217</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2           2.03768  0.70938  3.3660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis         0.44024 -0.09262  0.9731</span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span></span>
 <span class="r-plt img"><img src="saem-4.png" alt="" width="700" height="433"></span>
 <span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> saemix version used for fitting:      3.2 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> mkin version used for pre-fitting:  1.2.0 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> R version used for fitting:         4.2.2 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> Date of fit:     Tue Nov  1 14:12:07 2022 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> Date of summary: Tue Nov  1 14:12:07 2022 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Date of fit:     Mon Nov 14 21:06:30 2022 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Date of summary: Mon Nov 14 21:06:30 2022 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Equations:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span>
@@ -433,7 +445,7 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Model predictions using solution type analytical </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> Fitted in 8.45 s</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Fitted in 9.625 s</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Using 300, 100 iterations and 10 chains</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Variance model: Constant variance </span>
@@ -450,237 +462,237 @@ using <a href="mmkin.html">mmkin</a>.</p>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Results:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Likelihood computed by importance sampling</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   AIC   BIC logLik</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   842 836.9   -408</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>     AIC   BIC logLik</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   839.2 834.1 -406.6</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Optimised parameters:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>                       est.   lower   upper</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0           93.7701 91.1458 96.3945</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1           -5.8116 -7.5998 -4.0234</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis    -0.9608 -1.3654 -0.5562</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1             -2.5841 -3.6876 -1.4805</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2             -3.5228 -5.3254 -1.7203</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis           -0.1027 -0.8719  0.6665</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> a.1                 1.8856  1.6676  2.1037</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0         2.7682  0.7668  4.7695</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1         1.7447  0.4047  3.0848</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis  0.4525  0.1620  0.7431</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1           1.2423  0.4560  2.0285</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2           2.0390  0.7601  3.3180</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis         0.4439 -0.3069  1.1947</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>                        est.    lower   upper</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0           93.70402 91.04104 96.3670</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1           -5.83760 -7.66452 -4.0107</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis    -0.95718 -1.35955 -0.5548</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1             -2.35514 -3.39402 -1.3163</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2             -3.79634 -5.64009 -1.9526</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis           -0.02108 -0.66463  0.6225</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> a.1                 1.88191  1.66491  2.0989</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0         2.81628  0.78922  4.8433</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1         1.78751  0.42105  3.1540</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis  0.45016  0.16116  0.7391</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1           1.06923  0.31676  1.8217</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2           2.03768  0.70938  3.3660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis         0.44024 -0.09262  0.9731</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Correlation: </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>                 parnt_0 lg_k_A1 f_prnt_ log_k1  log_k2 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1        -0.0160                                </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis -0.0263  0.0612                        </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1           0.0100 -0.0014 -0.0033                </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2           0.0131  0.0050 -0.0011  0.0071        </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis        -0.0419 -0.0199  0.0026 -0.0765 -0.0707</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k_A1        -0.0147                                </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_qlogis -0.0269  0.0573                        </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k1           0.0263 -0.0011 -0.0040                </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> log_k2           0.0020  0.0065 -0.0002 -0.0776        </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> g_qlogis        -0.0248 -0.0180 -0.0004 -0.0903 -0.0603</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Random effects:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>                      est.   lower  upper</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0        2.7682  0.7668 4.7695</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1        1.7447  0.4047 3.0848</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis 0.4525  0.1620 0.7431</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1          1.2423  0.4560 2.0285</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2          2.0390  0.7601 3.3180</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis        0.4439 -0.3069 1.1947</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>                      est.    lower  upper</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.parent_0        2.8163  0.78922 4.8433</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k_A1        1.7875  0.42105 3.1540</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.f_parent_qlogis 0.4502  0.16116 0.7391</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k1          1.0692  0.31676 1.8217</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.log_k2          2.0377  0.70938 3.3660</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> SD.g_qlogis        0.4402 -0.09262 0.9731</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Variance model:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>      est. lower upper</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> a.1 1.886 1.668 2.104</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> a.1 1.882 1.665 2.099</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Backtransformed parameters:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>                     est.     lower    upper</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0       93.770115 9.115e+01 96.39447</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> k_A1            0.002993 5.005e-04  0.01789</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_to_A1  0.276720 2.034e-01  0.36443</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> k1              0.075467 2.503e-02  0.22753</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> k2              0.029516 4.867e-03  0.17902</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> g               0.474353 2.949e-01  0.66073</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_0       93.704015 9.104e+01 96.36699</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> k_A1            0.002916 4.692e-04  0.01812</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> f_parent_to_A1  0.277443 2.043e-01  0.36475</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> k1              0.094880 3.357e-02  0.26813</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> k2              0.022453 3.553e-03  0.14191</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> g               0.494731 3.397e-01  0.65078</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Resulting formation fractions:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>                 ff</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_A1   0.2767</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent_sink 0.7233</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_A1   0.2774</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent_sink 0.7226</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Estimated disappearance times:</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>          DT50   DT90 DT50back DT50_k1 DT50_k2</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> parent  14.56  58.26    17.54   9.185   23.48</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> A1     231.62 769.41       NA      NA      NA</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>         DT50   DT90 DT50back DT50_k1 DT50_k2</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> parent  14.0  72.38    21.79   7.306   30.87</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> A1     237.7 789.68       NA      NA      NA</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Data:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>          ds   name time observed predicted residual   std standardized</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    0     97.2  95.78623  1.41377 1.886     0.749758</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    0     96.4  95.78623  0.61377 1.886     0.325498</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    3     71.1  71.34666 -0.24666 1.886    -0.130812</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    3     69.2  71.34666 -2.14666 1.886    -1.138429</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    6     58.1  56.49768  1.60232 1.886     0.849749</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    6     56.6  56.49768  0.10232 1.886     0.054262</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   10     44.4  44.53511 -0.13511 1.886    -0.071650</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   10     43.4  44.53511 -1.13511 1.886    -0.601974</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   20     33.3  29.77451  3.52549 1.886     1.869656</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   20     29.2  29.77451 -0.57451 1.886    -0.304675</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   34     17.6  19.32540 -1.72540 1.886    -0.915023</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   34     18.0  19.32540 -1.32540 1.886    -0.702894</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   55     10.5  10.42781  0.07219 1.886     0.038282</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   55      9.3  10.42781 -1.12781 1.886    -0.598107</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   90      4.5   3.74190  0.75810 1.886     0.402037</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   90      4.7   3.74190  0.95810 1.886     0.508102</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  112      3.0   1.96485  1.03515 1.886     0.548966</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  112      3.4   1.96485  1.43515 1.886     0.761096</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  132      2.3   1.09395  1.20605 1.886     0.639596</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  132      2.7   1.09395  1.60605 1.886     0.851726</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    3      4.3   4.72702 -0.42702 1.886    -0.226458</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    3      4.6   4.72702 -0.12702 1.886    -0.067361</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    6      7.0   7.51314 -0.51314 1.886    -0.272128</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    6      7.2   7.51314 -0.31314 1.886    -0.166063</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   10      8.2   9.63719 -1.43719 1.886    -0.762179</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   10      8.0   9.63719 -1.63719 1.886    -0.868244</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   20     11.0  11.84931 -0.84931 1.886    -0.450409</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   20     13.7  11.84931  1.85069 1.886     0.981468</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   34     11.5  12.82336 -1.32336 1.886    -0.701808</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   34     12.7  12.82336 -0.12336 1.886    -0.065418</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   55     14.9  12.89456  2.00544 1.886     1.063533</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   55     14.5  12.89456  1.60544 1.886     0.851403</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   90     12.1  11.55919  0.54081 1.886     0.286806</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   90     12.3  11.55919  0.74081 1.886     0.392871</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  112      9.9  10.42334 -0.52334 1.886    -0.277539</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  112     10.2  10.42334 -0.22334 1.886    -0.118442</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  132      8.8   9.37987 -0.57987 1.886    -0.307519</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  132      7.8   9.37987 -1.57987 1.886    -0.837844</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    0     93.6  90.95702  2.64298 1.886     1.401639</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    0     92.3  90.95702  1.34298 1.886     0.712217</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    3     87.0  84.77506  2.22494 1.886     1.179942</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    3     82.2  84.77506 -2.57506 1.886    -1.365616</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    7     74.0  77.60962 -3.60962 1.886    -1.914268</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    7     73.9  77.60962 -3.70962 1.886    -1.967301</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   14     64.2  67.50646 -3.30646 1.886    -1.753499</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   14     69.5  67.50646  1.99354 1.886     1.057221</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   30     54.0  52.48909  1.51091 1.886     0.801271</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   30     54.6  52.48909  2.11091 1.886     1.119465</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   60     41.1  39.54372  1.55628 1.886     0.825335</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   60     38.4  39.54372 -1.14372 1.886    -0.606542</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   90     32.5  33.87968 -1.37968 1.886    -0.731676</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   90     35.5  33.87968  1.62032 1.886     0.859298</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  120     28.1  30.41071 -2.31071 1.886    -1.225427</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  120     29.0  30.41071 -1.41071 1.886    -0.748135</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  180     26.5  25.36386  1.13614 1.886     0.602524</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  180     27.6  25.36386  2.23614 1.886     1.185881</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    3      3.9   2.74863  1.15137 1.886     0.610600</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    3      3.1   2.74863  0.35137 1.886     0.186341</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    7      6.9   5.92686  0.97314 1.886     0.516081</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    7      6.6   5.92686  0.67314 1.886     0.356983</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   14     10.4  10.38800  0.01200 1.886     0.006362</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   14      8.3  10.38800 -2.08800 1.886    -1.107320</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   30     14.4  16.93529 -2.53529 1.886    -1.344524</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   30     13.7  16.93529 -3.23529 1.886    -1.715751</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   60     22.1  22.33044 -0.23044 1.886    -0.122209</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   60     22.3  22.33044 -0.03044 1.886    -0.016144</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   90     27.5  24.42300  3.07700 1.886     1.631809</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   90     25.4  24.42300  0.97700 1.886     0.518127</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  120     28.0  25.51140  2.48860 1.886     1.319768</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  120     26.6  25.51140  1.08860 1.886     0.577313</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  180     25.8  26.80282 -1.00282 1.886    -0.531818</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  180     25.3  26.80282 -1.50282 1.886    -0.796981</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    0     91.9  91.08733  0.81267 1.886     0.430980</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    0     90.8  91.08733 -0.28733 1.886    -0.152377</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    1     64.9  67.55332 -2.65332 1.886    -1.407123</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    1     66.2  67.55332 -1.35332 1.886    -0.717701</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    3     43.5  41.65811  1.84189 1.886     0.976800</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    3     44.1  41.65811  2.44189 1.886     1.294994</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    8     18.3  19.65773 -1.35773 1.886    -0.720038</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    8     18.1  19.65773 -1.55773 1.886    -0.826103</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   14     10.2  10.65118 -0.45118 1.886    -0.239269</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   14     10.8  10.65118  0.14882 1.886     0.078925</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   27      4.9   3.11694  1.78306 1.886     0.945601</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   27      3.3   3.11694  0.18306 1.886     0.097082</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   48      1.6   0.43165  1.16835 1.886     0.619603</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   48      1.5   0.43165  1.06835 1.886     0.566570</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   70      1.1   0.05441  1.04559 1.886     0.554503</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   70      0.9   0.05441  0.84559 1.886     0.448438</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    1      9.6   7.66431  1.93569 1.886     1.026546</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    1      7.7   7.66431  0.03569 1.886     0.018930</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    3     15.0  15.57948 -0.57948 1.886    -0.307311</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    3     15.1  15.57948 -0.47948 1.886    -0.254279</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    8     21.2  20.38988  0.81012 1.886     0.429625</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    8     21.1  20.38988  0.71012 1.886     0.376593</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   14     19.7  20.16439 -0.46439 1.886    -0.246276</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   14     18.9  20.16439 -1.26439 1.886    -0.670535</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   27     17.5  16.40918  1.09082 1.886     0.578489</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   27     15.9  16.40918 -0.50918 1.886    -0.270030</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   48      9.5  10.12011 -0.62011 1.886    -0.328861</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   48      9.8  10.12011 -0.32011 1.886    -0.169764</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   70      6.2   5.79080  0.40920 1.886     0.217011</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   70      6.1   5.79080  0.30920 1.886     0.163979</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    0     99.8  97.38786  2.41214 1.886     1.279218</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    0     98.3  97.38786  0.91214 1.886     0.483731</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    1     77.1  79.25431 -2.15431 1.886    -1.142481</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    1     77.2  79.25431 -2.05431 1.886    -1.089449</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    3     59.0  55.69866  3.30134 1.886     1.750781</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    3     58.1  55.69866  2.40134 1.886     1.273489</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    8     27.4  31.64893 -4.24893 1.886    -2.253314</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    8     29.2  31.64893 -2.44893 1.886    -1.298729</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   14     19.1  22.57316 -3.47316 1.886    -1.841901</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   14     29.6  22.57316  7.02684 1.886     3.726507</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   27     10.1  14.11345 -4.01345 1.886    -2.128430</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   27     18.2  14.11345  4.08655 1.886     2.167199</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   48      4.5   6.95586 -2.45586 1.886    -1.302400</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   48      9.1   6.95586  2.14414 1.886     1.137093</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   70      2.3   3.31753 -1.01753 1.886    -0.539619</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   70      2.9   3.31753 -0.41753 1.886    -0.221424</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   91      2.0   1.63642  0.36358 1.886     0.192816</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   91      1.8   1.63642  0.16358 1.886     0.086751</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent  120      2.0   0.61667  1.38333 1.886     0.733614</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent  120      2.2   0.61667  1.58333 1.886     0.839679</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    1      4.2   3.67247  0.52753 1.886     0.279763</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    1      3.9   3.67247  0.22753 1.886     0.120666</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    3      7.4   8.36240 -0.96240 1.886    -0.510385</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    3      7.9   8.36240 -0.46240 1.886    -0.245223</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    8     14.5  12.80590  1.69410 1.886     0.898422</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    8     13.7  12.80590  0.89410 1.886     0.474162</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   14     14.2  13.99625  0.20375 1.886     0.108053</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   14     12.2  13.99625 -1.79625 1.886    -0.952596</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   27     13.7  14.22730 -0.52730 1.886    -0.279641</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   27     13.2  14.22730 -1.02730 1.886    -0.544803</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   48     13.6  13.33713  0.26287 1.886     0.139406</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   48     15.4  13.33713  2.06287 1.886     1.093991</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   70     10.4  11.84008 -1.44008 1.886    -0.763708</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   70     11.6  11.84008 -0.24008 1.886    -0.127318</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   91     10.0  10.30732 -0.30732 1.886    -0.162980</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   91      9.5  10.30732 -0.80732 1.886    -0.428142</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1  120      9.1   8.33981  0.76019 1.886     0.403149</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1  120      9.0   8.33981  0.66019 1.886     0.350117</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    0     96.1  93.70349  2.39651 1.886     1.270926</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    0     94.3  93.70349  0.59651 1.886     0.316342</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    8     73.9  77.86253 -3.96253 1.886    -2.101429</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    8     73.9  77.86253 -3.96253 1.886    -2.101429</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   14     69.4  70.18665 -0.78665 1.886    -0.417182</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   14     73.1  70.18665  2.91335 1.886     1.545019</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   21     65.6  64.03245  1.56755 1.886     0.831308</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   21     65.3  64.03245  1.26755 1.886     0.672210</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   41     55.9  54.71491  1.18509 1.886     0.628480</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   41     54.4  54.71491 -0.31491 1.886    -0.167007</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   63     47.0  49.63436 -2.63436 1.886    -1.397065</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   63     49.3  49.63436 -0.33436 1.886    -0.177319</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   91     44.7  45.08853 -0.38853 1.886    -0.206049</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   91     46.7  45.08853  1.61147 1.886     0.854600</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent  120     42.1  41.07653  1.02347 1.886     0.542772</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent  120     41.3  41.07653  0.22347 1.886     0.118513</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1    8      3.3   4.08295 -0.78295 1.886    -0.415218</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1    8      3.4   4.08295 -0.68295 1.886    -0.362186</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   14      3.9   6.04367 -2.14367 1.886    -1.136841</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   14      2.9   6.04367 -3.14367 1.886    -1.667165</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   21      6.4   7.59693 -1.19693 1.886    -0.634761</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   21      7.2   7.59693 -0.39693 1.886    -0.210502</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   41      9.1   9.86436 -0.76436 1.886    -0.405361</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   41      8.5   9.86436 -1.36436 1.886    -0.723555</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   63     11.7  10.99397  0.70603 1.886     0.374425</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   63     12.0  10.99397  1.00603 1.886     0.533522</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   91     13.3  11.91274  1.38726 1.886     0.735696</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   91     13.2  11.91274  1.28726 1.886     0.682663</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1  120     14.3  12.66519  1.63481 1.886     0.866981</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1  120     12.1  12.66519 -0.56519 1.886    -0.299733</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    0     97.2  95.70025  1.49975 1.882      0.79693</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    0     96.4  95.70025  0.69975 1.882      0.37183</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    3     71.1  71.44670 -0.34670 1.882     -0.18423</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    3     69.2  71.44670 -2.24670 1.882     -1.19384</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    6     58.1  56.59283  1.50717 1.882      0.80087</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent    6     56.6  56.59283  0.00717 1.882      0.00381</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   10     44.4  44.56648 -0.16648 1.882     -0.08847</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   10     43.4  44.56648 -1.16648 1.882     -0.61984</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   20     33.3  29.76020  3.53980 1.882      1.88096</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   20     29.2  29.76020 -0.56020 1.882     -0.29767</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   34     17.6  19.39208 -1.79208 1.882     -0.95226</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   34     18.0  19.39208 -1.39208 1.882     -0.73971</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   55     10.5  10.55761 -0.05761 1.882     -0.03061</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   55      9.3  10.55761 -1.25761 1.882     -0.66826</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   90      4.5   3.84742  0.65258 1.882      0.34676</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent   90      4.7   3.84742  0.85258 1.882      0.45304</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  112      3.0   2.03997  0.96003 1.882      0.51013</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  112      3.4   2.03997  1.36003 1.882      0.72268</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  132      2.3   1.14585  1.15415 1.882      0.61328</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6 parent  132      2.7   1.14585  1.55415 1.882      0.82583</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    3      4.3   4.86054 -0.56054 1.882     -0.29786</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    3      4.6   4.86054 -0.26054 1.882     -0.13844</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    6      7.0   7.74179 -0.74179 1.882     -0.39417</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1    6      7.2   7.74179 -0.54179 1.882     -0.28789</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   10      8.2   9.94048 -1.74048 1.882     -0.92485</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   10      8.0   9.94048 -1.94048 1.882     -1.03112</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   20     11.0  12.19109 -1.19109 1.882     -0.63291</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   20     13.7  12.19109  1.50891 1.882      0.80180</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   34     11.5  13.10706 -1.60706 1.882     -0.85395</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   34     12.7  13.10706 -0.40706 1.882     -0.21630</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   55     14.9  13.06131  1.83869 1.882      0.97703</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   55     14.5  13.06131  1.43869 1.882      0.76448</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   90     12.1  11.54495  0.55505 1.882      0.29494</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1   90     12.3  11.54495  0.75505 1.882      0.40122</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  112      9.9  10.31533 -0.41533 1.882     -0.22070</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  112     10.2  10.31533 -0.11533 1.882     -0.06128</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  132      8.8   9.20222 -0.40222 1.882     -0.21373</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 6     A1  132      7.8   9.20222 -1.40222 1.882     -0.74510</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    0     93.6  90.82357  2.77643 1.882      1.47532</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    0     92.3  90.82357  1.47643 1.882      0.78453</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    3     87.0  84.73448  2.26552 1.882      1.20384</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    3     82.2  84.73448 -2.53448 1.882     -1.34675</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    7     74.0  77.65013 -3.65013 1.882     -1.93958</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent    7     73.9  77.65013 -3.75013 1.882     -1.99272</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   14     64.2  67.60639 -3.40639 1.882     -1.81007</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   14     69.5  67.60639  1.89361 1.882      1.00621</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   30     54.0  52.53663  1.46337 1.882      0.77760</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   30     54.6  52.53663  2.06337 1.882      1.09642</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   60     41.1  39.42728  1.67272 1.882      0.88884</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   60     38.4  39.42728 -1.02728 1.882     -0.54587</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   90     32.5  33.76360 -1.26360 1.882     -0.67144</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent   90     35.5  33.76360  1.73640 1.882      0.92268</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  120     28.1  30.39975 -2.29975 1.882     -1.22203</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  120     29.0  30.39975 -1.39975 1.882     -0.74379</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  180     26.5  25.62379  0.87621 1.882      0.46559</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7 parent  180     27.6  25.62379  1.97621 1.882      1.05010</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    3      3.9   2.70005  1.19995 1.882      0.63762</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    3      3.1   2.70005  0.39995 1.882      0.21252</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    7      6.9   5.83475  1.06525 1.882      0.56605</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1    7      6.6   5.83475  0.76525 1.882      0.40663</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   14     10.4  10.26142  0.13858 1.882      0.07364</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   14      8.3  10.26142 -1.96142 1.882     -1.04225</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   30     14.4  16.82999 -2.42999 1.882     -1.29123</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   30     13.7  16.82999 -3.12999 1.882     -1.66319</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   60     22.1  22.32486 -0.22486 1.882     -0.11949</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   60     22.3  22.32486 -0.02486 1.882     -0.01321</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   90     27.5  24.45927  3.04073 1.882      1.61576</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1   90     25.4  24.45927  0.94073 1.882      0.49988</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  120     28.0  25.54862  2.45138 1.882      1.30260</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  120     26.6  25.54862  1.05138 1.882      0.55868</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  180     25.8  26.82277 -1.02277 1.882     -0.54347</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 7     A1  180     25.3  26.82277 -1.52277 1.882     -0.80916</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    0     91.9  91.16791  0.73209 1.882      0.38901</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    0     90.8  91.16791 -0.36791 1.882     -0.19550</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    1     64.9  67.58358 -2.68358 1.882     -1.42598</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    1     66.2  67.58358 -1.38358 1.882     -0.73520</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    3     43.5  41.62086  1.87914 1.882      0.99853</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    3     44.1  41.62086  2.47914 1.882      1.31735</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    8     18.3  19.60116 -1.30116 1.882     -0.69140</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent    8     18.1  19.60116 -1.50116 1.882     -0.79768</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   14     10.2  10.63101 -0.43101 1.882     -0.22903</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   14     10.8  10.63101  0.16899 1.882      0.08980</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   27      4.9   3.12435  1.77565 1.882      0.94354</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   27      3.3   3.12435  0.17565 1.882      0.09334</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   48      1.6   0.43578  1.16422 1.882      0.61864</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   48      1.5   0.43578  1.06422 1.882      0.56550</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   70      1.1   0.05534  1.04466 1.882      0.55510</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8 parent   70      0.9   0.05534  0.84466 1.882      0.44883</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    1      9.6   7.63450  1.96550 1.882      1.04442</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    1      7.7   7.63450  0.06550 1.882      0.03481</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    3     15.0  15.52593 -0.52593 1.882     -0.27947</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    3     15.1  15.52593 -0.42593 1.882     -0.22633</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    8     21.2  20.32192  0.87808 1.882      0.46659</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1    8     21.1  20.32192  0.77808 1.882      0.41345</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   14     19.7  20.09721 -0.39721 1.882     -0.21107</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   14     18.9  20.09721 -1.19721 1.882     -0.63617</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   27     17.5  16.37477  1.12523 1.882      0.59792</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   27     15.9  16.37477 -0.47477 1.882     -0.25228</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   48      9.5  10.13141 -0.63141 1.882     -0.33551</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   48      9.8  10.13141 -0.33141 1.882     -0.17610</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   70      6.2   5.81827  0.38173 1.882      0.20284</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 8     A1   70      6.1   5.81827  0.28173 1.882      0.14970</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    0     99.8  97.48728  2.31272 1.882      1.22892</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    0     98.3  97.48728  0.81272 1.882      0.43186</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    1     77.1  79.29476 -2.19476 1.882     -1.16624</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    1     77.2  79.29476 -2.09476 1.882     -1.11310</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    3     59.0  55.67060  3.32940 1.882      1.76915</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    3     58.1  55.67060  2.42940 1.882      1.29092</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    8     27.4  31.57871 -4.17871 1.882     -2.22046</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent    8     29.2  31.57871 -2.37871 1.882     -1.26398</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   14     19.1  22.51546 -3.41546 1.882     -1.81489</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   14     29.6  22.51546  7.08454 1.882      3.76454</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   27     10.1  14.09074 -3.99074 1.882     -2.12057</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   27     18.2  14.09074  4.10926 1.882      2.18355</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   48      4.5   6.95747 -2.45747 1.882     -1.30584</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   48      9.1   6.95747  2.14253 1.882      1.13848</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   70      2.3   3.32472 -1.02472 1.882     -0.54451</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   70      2.9   3.32472 -0.42472 1.882     -0.22569</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   91      2.0   1.64300  0.35700 1.882      0.18970</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent   91      1.8   1.64300  0.15700 1.882      0.08343</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent  120      2.0   0.62073  1.37927 1.882      0.73291</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9 parent  120      2.2   0.62073  1.57927 1.882      0.83918</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    1      4.2   3.64568  0.55432 1.882      0.29455</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    1      3.9   3.64568  0.25432 1.882      0.13514</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    3      7.4   8.30173 -0.90173 1.882     -0.47916</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    3      7.9   8.30173 -0.40173 1.882     -0.21347</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    8     14.5  12.71589  1.78411 1.882      0.94803</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1    8     13.7  12.71589  0.98411 1.882      0.52293</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   14     14.2  13.90452  0.29548 1.882      0.15701</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   14     12.2  13.90452 -1.70452 1.882     -0.90574</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   27     13.7  14.15523 -0.45523 1.882     -0.24190</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   27     13.2  14.15523 -0.95523 1.882     -0.50759</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   48     13.6  13.31038  0.28962 1.882      0.15389</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   48     15.4  13.31038  2.08962 1.882      1.11037</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   70     10.4  11.85965 -1.45965 1.882     -0.77562</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   70     11.6  11.85965 -0.25965 1.882     -0.13797</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   91     10.0  10.36294 -0.36294 1.882     -0.19286</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1   91      9.5  10.36294 -0.86294 1.882     -0.45855</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1  120      9.1   8.43003  0.66997 1.882      0.35601</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   Dataset 9     A1  120      9.0   8.43003  0.56997 1.882      0.30287</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    0     96.1  93.95603  2.14397 1.882      1.13925</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    0     94.3  93.95603  0.34397 1.882      0.18278</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    8     73.9  77.70592 -3.80592 1.882     -2.02237</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent    8     73.9  77.70592 -3.80592 1.882     -2.02237</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   14     69.4  70.04570 -0.64570 1.882     -0.34311</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   14     73.1  70.04570  3.05430 1.882      1.62298</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   21     65.6  64.01710  1.58290 1.882      0.84111</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   21     65.3  64.01710  1.28290 1.882      0.68170</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   41     55.9  54.98434  0.91566 1.882      0.48656</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   41     54.4  54.98434 -0.58434 1.882     -0.31050</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   63     47.0  49.87137 -2.87137 1.882     -1.52577</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   63     49.3  49.87137 -0.57137 1.882     -0.30361</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   91     44.7  45.06727 -0.36727 1.882     -0.19516</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent   91     46.7  45.06727  1.63273 1.882      0.86759</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent  120     42.1  40.76402  1.33598 1.882      0.70991</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10 parent  120     41.3  40.76402  0.53598 1.882      0.28481</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1    8      3.3   4.14599 -0.84599 1.882     -0.44954</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1    8      3.4   4.14599 -0.74599 1.882     -0.39640</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   14      3.9   6.08478 -2.18478 1.882     -1.16093</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   14      2.9   6.08478 -3.18478 1.882     -1.69231</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   21      6.4   7.59411 -1.19411 1.882     -0.63452</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   21      7.2   7.59411 -0.39411 1.882     -0.20942</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   41      9.1   9.78292 -0.68292 1.882     -0.36289</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   41      8.5   9.78292 -1.28292 1.882     -0.68171</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   63     11.7  10.93274  0.76726 1.882      0.40770</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   63     12.0  10.93274  1.06726 1.882      0.56711</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   91     13.3  11.93986  1.36014 1.882      0.72274</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1   91     13.2  11.93986  1.26014 1.882      0.66961</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1  120     14.3  12.79238  1.50762 1.882      0.80111</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>  Dataset 10     A1  120     12.1  12.79238 -0.69238 1.882     -0.36791</span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="co"># The following takes about 6 minutes</span></span></span>
 <span class="r-in"><span><span class="co">#f_saem_dfop_sfo_deSolve &lt;- saem(f_mmkin["DFOP-SFO", ], solution_type = "deSolve",</span></span></span>
diff --git a/docs/dev/reference/summary.mkinfit.html b/docs/dev/reference/summary.mkinfit.html
index 993544c7..3994a424 100644
--- a/docs/dev/reference/summary.mkinfit.html
+++ b/docs/dev/reference/summary.mkinfit.html
@@ -108,7 +108,7 @@ values.</p>
     <div id="arguments">
     <h2>Arguments</h2>
     <dl><dt>object</dt>
-<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd>
+<dd><p>an object of class <a href="mkinfit.html">mkinfit</a>.</p></dd>
 
 
 <dt>data</dt>
@@ -189,7 +189,8 @@ model.</p></dd>
 <dd><p>The DT50 and DT90 values for each observed variable.</p></dd>
 
 <dt>SFORB</dt>
-<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd>
+<dd><p>If applicable, eigenvalues and fractional eigenvector component
+g of SFORB systems in the model.</p></dd>
 
 </dl><p>The print method is called for its side effect, i.e. printing the summary.</p>
     </div>
@@ -212,8 +213,8 @@ EC Document Reference Sanco/10058/2005 version 2.0, 434 pp,
 <span class="r-in"><span>  <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_A</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> mkin version used for fitting:    1.2.0 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> R version used for fitting:       4.2.2 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> Date of fit:     Tue Nov  1 14:12:09 2022 </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> Date of summary: Tue Nov  1 14:12:09 2022 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Date of fit:     Mon Nov 14 21:06:31 2022 </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> Date of summary: Mon Nov 14 21:06:31 2022 </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> Equations:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> d_parent/dt = - k_parent * parent</span>
diff --git a/docs/dev/sitemap.xml b/docs/dev/sitemap.xml
index 17f86f6c..04cf230e 100644
--- a/docs/dev/sitemap.xml
+++ b/docs/dev/sitemap.xml
@@ -37,6 +37,9 @@
     <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/multistart.html</loc>
   </url>
   <url>
+    <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/saem_benchmarks.html</loc>
+  </url>
+  <url>
     <loc>https://pkgdown.jrwb.de/mkin/authors.html</loc>
   </url>
   <url>
author	Johannes Ranke <jranke@uni-bremen.de>	2022-11-14 21:47:45 +0100
committer	Johannes Ranke <jranke@uni-bremen.de>	2022-11-14 21:47:45 +0100
commit	9275bcb39b5ee25753ef489d334b4906401970b3 (patch)
tree	9ddaaf518f8655f38a44f1a0516335989085d490 /docs
parent	d6168b0851a52adeaed8099e41a960d79acedae9 (diff)