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author | Johannes Ranke <jranke@uni-bremen.de> | 2022-02-08 17:17:29 +0100 |
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committer | Johannes Ranke <jranke@uni-bremen.de> | 2022-02-08 17:17:29 +0100 |
commit | 0fa8a770812775d697717ad723f7f61fb04b7fef (patch) | |
tree | 17473ddf787541745d47dab063bc643ec59a9557 /man/summary.saem.mmkin.Rd | |
parent | d081384ddcb75a9f92fad33e4e3f6d6796f98e67 (diff) | |
parent | c0638c84568d475b3b059e2c6e593e6f03b846bc (diff) |
Merge branch 'nlmixr'
Diffstat (limited to 'man/summary.saem.mmkin.Rd')
-rw-r--r-- | man/summary.saem.mmkin.Rd | 100 |
1 files changed, 100 insertions, 0 deletions
diff --git a/man/summary.saem.mmkin.Rd b/man/summary.saem.mmkin.Rd new file mode 100644 index 00000000..67cb3cbb --- /dev/null +++ b/man/summary.saem.mmkin.Rd @@ -0,0 +1,100 @@ +% Generated by roxygen2: do not edit by hand +% Please edit documentation in R/summary.saem.mmkin.R +\name{summary.saem.mmkin} +\alias{summary.saem.mmkin} +\alias{print.summary.saem.mmkin} +\title{Summary method for class "saem.mmkin"} +\usage{ +\method{summary}{saem.mmkin}(object, data = FALSE, verbose = FALSE, distimes = TRUE, ...) + +\method{print}{summary.saem.mmkin}(x, digits = max(3, getOption("digits") - 3), verbose = x$verbose, ...) +} +\arguments{ +\item{object}{an object of class \link{saem.mmkin}} + +\item{data}{logical, indicating whether the full data should be included in +the summary.} + +\item{verbose}{Should the summary be verbose?} + +\item{distimes}{logical, indicating whether DT50 and DT90 values should be +included.} + +\item{\dots}{optional arguments passed to methods like \code{print}.} + +\item{x}{an object of class \link{summary.saem.mmkin}} + +\item{digits}{Number of digits to use for printing} +} +\value{ +The summary function returns a list based on the \link[saemix:SaemixObject-class]{saemix::SaemixObject} +obtained in the fit, with at least the following additional components +\item{saemixversion, mkinversion, Rversion}{The saemix, mkin and R versions used} +\item{date.fit, date.summary}{The dates where the fit and the summary were +produced} +\item{diffs}{The differential equations used in the degradation model} +\item{use_of_ff}{Was maximum or minimum use made of formation fractions} +\item{data}{The data} +\item{confint_trans}{Transformed parameters as used in the optimisation, with confidence intervals} +\item{confint_back}{Backtransformed parameters, with confidence intervals if available} +\item{confint_errmod}{Error model parameters with confidence intervals} +\item{ff}{The estimated formation fractions derived from the fitted +model.} +\item{distimes}{The DT50 and DT90 values for each observed variable.} +\item{SFORB}{If applicable, eigenvalues of SFORB components of the model.} +The print method is called for its side effect, i.e. printing the summary. +} +\description{ +Lists model equations, initial parameter values, optimised parameters +for fixed effects (population), random effects (deviations from the +population mean) and residual error model, as well as the resulting +endpoints such as formation fractions and DT50 values. Optionally +(default is FALSE), the data are listed in full. +} +\examples{ +# Generate five datasets following DFOP-SFO kinetics +sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120) +dfop_sfo <- mkinmod(parent = mkinsub("DFOP", "m1"), + m1 = mkinsub("SFO"), quiet = TRUE) +set.seed(1234) +k1_in <- rlnorm(5, log(0.1), 0.3) +k2_in <- rlnorm(5, log(0.02), 0.3) +g_in <- plogis(rnorm(5, qlogis(0.5), 0.3)) +f_parent_to_m1_in <- plogis(rnorm(5, qlogis(0.3), 0.3)) +k_m1_in <- rlnorm(5, log(0.02), 0.3) + +pred_dfop_sfo <- function(k1, k2, g, f_parent_to_m1, k_m1) { + mkinpredict(dfop_sfo, + c(k1 = k1, k2 = k2, g = g, f_parent_to_m1 = f_parent_to_m1, k_m1 = k_m1), + c(parent = 100, m1 = 0), + sampling_times) +} + +ds_mean_dfop_sfo <- lapply(1:5, function(i) { + mkinpredict(dfop_sfo, + c(k1 = k1_in[i], k2 = k2_in[i], g = g_in[i], + f_parent_to_m1 = f_parent_to_m1_in[i], k_m1 = k_m1_in[i]), + c(parent = 100, m1 = 0), + sampling_times) +}) +names(ds_mean_dfop_sfo) <- paste("ds", 1:5) + +ds_syn_dfop_sfo <- lapply(ds_mean_dfop_sfo, function(ds) { + add_err(ds, + sdfunc = function(value) sqrt(1^2 + value^2 * 0.07^2), + n = 1)[[1]] +}) + +\dontrun{ +# Evaluate using mmkin and saem +f_mmkin_dfop_sfo <- mmkin(list(dfop_sfo), ds_syn_dfop_sfo, + quiet = TRUE, error_model = "tc", cores = 5) +f_saem_dfop_sfo <- saem(f_mmkin_dfop_sfo) +summary(f_saem_dfop_sfo, data = TRUE) +} + +} +\author{ +Johannes Ranke for the mkin specific parts +saemix authors for the parts inherited from saemix. +} |