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authorJohannes Ranke <jranke@uni-bremen.de>2022-03-01 10:42:56 +0100
committerJohannes Ranke <jranke@uni-bremen.de>2022-03-01 10:42:56 +0100
commitc013e35de82825786a12fa98a202219dd241257e (patch)
treed0bf144328f1a43b5cd5b5b33ed319829c8eab9d /print_nlmixr_saem_biphasic_tc.txt
parent1d581d24bc85402770a195b44e453a1449597faf (diff)
Some more tests for nlmixr.mmkin
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+Kinetic nonlinear mixed-effects model fit by saem using nlmixr
+Structural model:
+d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
+ time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))
+ * parent
+d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)
+ * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *
+ exp(-k2 * time))) * parent - k_m1 * m1
+
+Data:
+507 observations of 2 variable(s) grouped in 15 datasets
+
+Likelihood:
+ AIC BIC logLik
+ 2400 2468 -1184
+
+Fitted parameters:
+ Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD)
+parent_0 100 0.685 0.682 100 (99, 102) 0.278
+log_k_m1 -5.35 0.0812 1.52 0.00477 (0.00407, 0.00559) 13.7
+f_parent_qlogis -0.091 0.096 106 0.477 (0.431, 0.524) 0.320
+log_k1 -2.76 0.0969 3.5 0.063 (0.0521, 0.0762) 29.9
+log_k2 -4.49 0.0658 1.47 0.0113 (0.00991, 0.0128) 18.6
+g_qlogis -0.167 0.142 85.3 0.458 (0.39, 0.528) 0.339
+sigma_low_parent 1.04 1.04
+rsd_high_parent 0.0531 0.0531
+sigma_low_m1 0.819 0.819
+rsd_high_m1 0.058 0.058
+ Shrink(SD)%
+parent_0 87.7%>
+log_k_m1 44.8%>
+f_parent_qlogis -0.375%>
+log_k1 6.76%<
+log_k2 10.4%<
+g_qlogis 20.3%=
+sigma_low_parent
+rsd_high_parent
+sigma_low_m1
+rsd_high_m1

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