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authorJohannes Ranke <jranke@uni-bremen.de>2020-12-09 13:08:01 +0100
committerJohannes Ranke <jranke@uni-bremen.de>2020-12-09 13:08:01 +0100
commit3b15daaf373ebc36da2eb92f2e37ed569731f07d (patch)
tree75339d1b69c30edf26251a48fedeee70b6069d82 /tests/testthat/test_saem.R
parentc6944440507b4b793a3715704122dfffb350a5a0 (diff)
More tests
Diffstat (limited to 'tests/testthat/test_saem.R')
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diff --git a/tests/testthat/test_saem.R b/tests/testthat/test_saem.R
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-context("Nonlinear mixed effects models fitted with SAEM from saemix")
-
-set.seed(123456)
-sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)
-n <- n_biphasic <- 15
-log_sd <- 0.3
-err_1 = list(const = 1, prop = 0.05)
-tc <- function(value) sigma_twocomp(value, err_1$const, err_1$prop)
-const <- function(value) 2
-
-SFO <- mkinmod(parent = mkinsub("SFO"))
-k_parent = rlnorm(n, log(0.03), log_sd)
-ds_sfo <- lapply(1:n, function(i) {
- ds_mean <- mkinpredict(SFO, c(k_parent = k_parent[i]),
- c(parent = 100), sampling_times)
- add_err(ds_mean, tc, n = 1)[[1]]
-})
-
-DFOP <- mkinmod(parent = mkinsub("DFOP"))
-dfop_pop <- list(parent_0 = 100, k1 = 0.06, k2 = 0.015, g = 0.4)
-dfop_parms <- as.matrix(data.frame(
- k1 = rlnorm(n, log(dfop_pop$k1), log_sd),
- k2 = rlnorm(n, log(dfop_pop$k2), log_sd),
- g = plogis(rnorm(n, qlogis(dfop_pop$g), log_sd))))
-ds_dfop <- lapply(1:n, function(i) {
- ds_mean <- mkinpredict(DFOP, dfop_parms[i, ],
- c(parent = dfop_pop$parent_0), sampling_times)
- add_err(ds_mean, const, n = 1)[[1]]
-})
-
-set.seed(123456)
-DFOP_SFO <- mkinmod(
- parent = mkinsub("DFOP", "m1"),
- m1 = mkinsub("SFO"),
- quiet = TRUE)
-syn_biphasic_parms <- as.matrix(data.frame(
- k1 = rlnorm(n_biphasic, log(0.05), log_sd),
- k2 = rlnorm(n_biphasic, log(0.01), log_sd),
- g = plogis(rnorm(n_biphasic, 0, log_sd)),
- f_parent_to_m1 = plogis(rnorm(n_biphasic, 0, log_sd)),
- k_m1 = rlnorm(n_biphasic, log(0.002), log_sd)))
-ds_biphasic_mean <- lapply(1:n_biphasic,
- function(i) {
- mkinpredict(DFOP_SFO, syn_biphasic_parms[i, ],
- c(parent = 100, m1 = 0), sampling_times)
- }
-)
-ds_biphasic <- lapply(ds_biphasic_mean, function(ds) {
- add_err(ds,
- sdfunc = function(value) sqrt(err_1$const^2 + value^2 * err_1$prop^2),
- n = 1, secondary = "m1")[[1]]
-})
-
-test_that("Parent only models can be fitted with saemix", {
- # Some fits were done in the setup script
- mmkin_sfo_2 <- mmkin("SFO", ds_sfo, fixed_initials = c(parent = 100), quiet = TRUE)
-
- sfo_saemix_2 <- saem(mmkin_sfo_1, quiet = TRUE, transformations = "mkin")
- sfo_saemix_3 <- expect_error(saem(mmkin_sfo_2, quiet = TRUE), "at least two parameters")
- s_sfo_s1 <- summary(sfo_saemix_1)
- s_sfo_s2 <- summary(sfo_saemix_2)
-
- sfo_nlme_1 <- expect_warning(nlme(mmkin_sfo_1), "not converge")
- s_sfo_n <- summary(sfo_nlme_1)
-
- # Compare with input
- expect_equal(round(s_sfo_s2$confint_ranef["SD.log_k_parent", "est."], 1), 0.3)
- # k_parent is a bit different from input 0.03 here
- expect_equal(round(s_sfo_s1$confint_back["k_parent", "est."], 3), 0.035)
- expect_equal(round(s_sfo_s2$confint_back["k_parent", "est."], 3), 0.035)
-
- # But the result is pretty unanimous between methods
- expect_equal(round(s_sfo_s1$confint_back["k_parent", "est."], 3),
- round(s_sfo_s2$confint_back["k_parent", "est."], 3))
- expect_equal(round(s_sfo_s1$confint_back["k_parent", "est."], 3),
- round(s_sfo_n$confint_back["k_parent", "est."], 3))
-
- mmkin_dfop_1 <- mmkin("DFOP", ds_dfop, quiet = TRUE)
-
- dfop_saemix_1 <- saem(mmkin_dfop_1, quiet = TRUE, transformations = "mkin")
- dfop_saemix_2 <- saem(mmkin_dfop_1, quiet = TRUE, transformations = "saemix")
- dfop_nlme_1 <- nlme(mmkin_dfop_1)
- s_dfop_s1 <- summary(dfop_saemix_1)
- s_dfop_s2 <- summary(dfop_saemix_2)
- s_dfop_n <- summary(dfop_nlme_1)
-
- dfop_pop <- as.numeric(dfop_pop)
- expect_true(all(s_dfop_s1$confint_back[, "lower"] < dfop_pop))
- expect_true(all(s_dfop_s1$confint_back[, "upper"] > dfop_pop))
- expect_true(all(s_dfop_s2$confint_back[, "lower"] < dfop_pop))
- expect_true(all(s_dfop_s2$confint_back[, "upper"] > dfop_pop))
-
-
- # We get < 20% deviations with transformations made in mkin
- rel_diff_1 <- (s_dfop_s1$confint_back[, "est."] - dfop_pop) / dfop_pop
- expect_true(all(rel_diff_1 < 0.2))
-
- # We get < 8% deviations with transformations made in saemix
- rel_diff_2 <- (s_dfop_s2$confint_back[, "est."] - dfop_pop) / dfop_pop
- expect_true(all(rel_diff_2 < 0.08))
-})
-
-test_that("Print methods work", {
- expect_known_output(print(sfo_saemix_1, digits = 1), "print_sfo_saemix_1.txt")
- expect_known_output(print(mmkin_biphasic_mixed, digits = 2), "print_mmkin_biphasic_mixed.txt")
-})
-
-test_that("Saemix results are reproducible", {
-
- test_summary <- summary(saem_biphasic_s)
- test_summary$saemixversion <- "Dummy 0.0 for testing"
- test_summary$mkinversion <- "Dummy 0.0 for testing"
- test_summary$Rversion <- "Dummy R version for testing"
- test_summary$date.fit <- "Dummy date for testing"
- test_summary$date.summary <- "Dummy date for testing"
- test_summary$time <- c(elapsed = "test time 0")
-
- expect_known_output(print(test_summary, digits = 2), "summary_saem_biphasic_s.txt")
-
- dfop_sfo_pop <- as.numeric(dfop_sfo_pop)
- ci_dfop_sfo_s_s <- summary(saem_biphasic_s)$confint_back
- expect_true(all(ci_dfop_sfo_s_s[, "lower"] < dfop_sfo_pop))
- expect_true(all(ci_dfop_sfo_s_s[, "upper"] > dfop_sfo_pop))
-
- # The following does not work, as k1 and k2 are not fitted well
- ci_dfop_sfo_s_m <- summary(saem_biphasic_m)$confint_back
- # expect_true(all(ci_dfop_sfo_s_m[, "lower"] < dfop_sfo_pop))
- # expect_true(all(ci_dfop_sfo_s_m[, "upper"] > dfop_sfo_pop))
-
- # Somehow this does not work at the moment. But it took forever (~ 10 min) anyways...
- #saem_biphasic_2 <- saem(mmkin_biphasic, solution_type = "deSolve", quiet = TRUE)
-
-})

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