diff options
241 files changed, 32692 insertions, 16887 deletions
diff --git a/DESCRIPTION b/DESCRIPTION index e57a6758..41237793 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -2,7 +2,7 @@ Package: mkin Type: Package Title: Kinetic Evaluation of Chemical Degradation Data Version: 1.1.0 -Date: 2022-02-28 +Date: 2022-03-02 Authors@R: c( person("Johannes", "Ranke", role = c("aut", "cre", "cph"), email = "jranke@uni-bremen.de", @@ -156,7 +156,6 @@ nlmixr::nlmixr #' # lowest AIC #' plot(f_nlmixr_fomc_sfo_focei_obs_tc) #' summary(f_nlmixr_fomc_sfo_focei_obs_tc) -#' } #' #' # Two parallel metabolites #' dmta_ds <- lapply(1:7, function(i) { @@ -180,7 +179,7 @@ nlmixr::nlmixr #' dmta_ds, quiet = TRUE, error_model = "obs") #' nlmixr_model(f_dmta_sfo_sfo2) #' nlmixr_focei_dmta_sfo_sfo2 <- nlmixr(f_dmta_sfo_sfo2, est = "focei") -#' +#' } #' @export nlmixr.mmkin <- function(object, data = NULL, est = NULL, control = list(), diff --git a/docs/404.html b/docs/404.html index af049fc2..3215181e 100644 --- a/docs/404.html +++ b/docs/404.html @@ -1,66 +1,27 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - 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- - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-title-body"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -71,70 +32,73 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="https://pkgdown.jrwb.de/mkin/index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> <ul class="nav navbar-nav"> - <li> - <a href="reference/index.html">Functions and data</a> +<li> + <a href="https://pkgdown.jrwb.de/mkin/reference/index.html">Functions and data</a> </li> <li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + <a href="https://pkgdown.jrwb.de/mkin/#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> Articles <span class="caret"></span> </a> <ul class="dropdown-menu" role="menu"> +<li> + <a href="https://pkgdown.jrwb.de/mkin/articles/mkin.html">Introduction to mkin</a> + </li> <li> - <a href="articles/mkin.html">Introduction to mkin</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> </li> <li> - <a href="articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> - <a href="articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> </li> <li> - <a href="articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> - <a href="articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> </li> <li> - <a href="articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/twa.html">Calculation of time weighted average concentrations with mkin</a> </li> <li> - <a href="articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> </li> <li> - <a href="articles/web_only/benchmarks.html">Some benchmark timings</a> + <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/benchmarks.html">Some benchmark timings</a> </li> </ul> </li> <li> - <a href="news/index.html">News</a> + <a href="https://pkgdown.jrwb.de/mkin/news/index.html">News</a> </li> </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> +<ul class="nav navbar-nav navbar-right"> +<li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> </ul> - - </div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> +</div> +<!--/.nav-collapse --> + </div> +<!--/.container --> +</div> +<!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="contents col-md-9"> <div class="page-header"> <h1>Page not found (404)</h1> @@ -145,31 +109,31 @@ Content not found. Please use links in the navbar. </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> </nav> - </div> +</div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> - </div> +</div> + + </body> </html> - - diff --git a/docs/articles/FOCUS_D.html b/docs/articles/FOCUS_D.html index 1bfba6e5..7ef16ef8 100644 --- a/docs/articles/FOCUS_D.html +++ b/docs/articles/FOCUS_D.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,15 +99,15 @@ - </header><script src="FOCUS_D_files/header-attrs-2.7/header-attrs.js"></script><script src="FOCUS_D_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="FOCUS_D_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Example evaluation of FOCUS Example Dataset D</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 31 January 2019 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 31 January 2019 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/FOCUS_D.rmd"><code>vignettes/FOCUS_D.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_D.rmd" class="external-link"><code>vignettes/FOCUS_D.rmd</code></a></small> <div class="hidden name"><code>FOCUS_D.rmd</code></div> </div> @@ -111,72 +116,72 @@ <p>This is just a very simple vignette showing how to fit a degradation model for a parent compound with one transformation product using <code>mkin</code>. After loading the library we look at the data. We have observed concentrations in the column named <code>value</code> at the times specified in column <code>time</code> for the two observed variables named <code>parent</code> and <code>m1</code>.</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span><span class="op">)</span></code></pre></div> -<pre><code>## name time value -## 1 parent 0 99.46 -## 2 parent 0 102.04 -## 3 parent 1 93.50 -## 4 parent 1 92.50 -## 5 parent 3 63.23 -## 6 parent 3 68.99 -## 7 parent 7 52.32 -## 8 parent 7 55.13 -## 9 parent 14 27.27 -## 10 parent 14 26.64 -## 11 parent 21 11.50 -## 12 parent 21 11.64 -## 13 parent 35 2.85 -## 14 parent 35 2.91 -## 15 parent 50 0.69 -## 16 parent 50 0.63 -## 17 parent 75 0.05 -## 18 parent 75 0.06 -## 19 parent 100 NA -## 20 parent 100 NA -## 21 parent 120 NA -## 22 parent 120 NA -## 23 m1 0 0.00 -## 24 m1 0 0.00 -## 25 m1 1 4.84 -## 26 m1 1 5.64 -## 27 m1 3 12.91 -## 28 m1 3 12.96 -## 29 m1 7 22.97 -## 30 m1 7 24.47 -## 31 m1 14 41.69 -## 32 m1 14 33.21 -## 33 m1 21 44.37 -## 34 m1 21 46.44 -## 35 m1 35 41.22 -## 36 m1 35 37.95 -## 37 m1 50 41.19 -## 38 m1 50 40.01 -## 39 m1 75 40.09 -## 40 m1 75 33.85 -## 41 m1 100 31.04 -## 42 m1 100 33.13 -## 43 m1 120 25.15 -## 44 m1 120 33.31</code></pre> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## name time value</span> +<span class="co">## 1 parent 0 99.46</span> +<span class="co">## 2 parent 0 102.04</span> +<span class="co">## 3 parent 1 93.50</span> +<span class="co">## 4 parent 1 92.50</span> +<span class="co">## 5 parent 3 63.23</span> +<span class="co">## 6 parent 3 68.99</span> +<span class="co">## 7 parent 7 52.32</span> +<span class="co">## 8 parent 7 55.13</span> +<span class="co">## 9 parent 14 27.27</span> +<span class="co">## 10 parent 14 26.64</span> +<span class="co">## 11 parent 21 11.50</span> +<span class="co">## 12 parent 21 11.64</span> +<span class="co">## 13 parent 35 2.85</span> +<span class="co">## 14 parent 35 2.91</span> +<span class="co">## 15 parent 50 0.69</span> +<span class="co">## 16 parent 50 0.63</span> +<span class="co">## 17 parent 75 0.05</span> +<span class="co">## 18 parent 75 0.06</span> +<span class="co">## 19 parent 100 NA</span> +<span class="co">## 20 parent 100 NA</span> +<span class="co">## 21 parent 120 NA</span> +<span class="co">## 22 parent 120 NA</span> +<span class="co">## 23 m1 0 0.00</span> +<span class="co">## 24 m1 0 0.00</span> +<span class="co">## 25 m1 1 4.84</span> +<span class="co">## 26 m1 1 5.64</span> +<span class="co">## 27 m1 3 12.91</span> +<span class="co">## 28 m1 3 12.96</span> +<span class="co">## 29 m1 7 22.97</span> +<span class="co">## 30 m1 7 24.47</span> +<span class="co">## 31 m1 14 41.69</span> +<span class="co">## 32 m1 14 33.21</span> +<span class="co">## 33 m1 21 44.37</span> +<span class="co">## 34 m1 21 46.44</span> +<span class="co">## 35 m1 35 41.22</span> +<span class="co">## 36 m1 35 37.95</span> +<span class="co">## 37 m1 50 41.19</span> +<span class="co">## 38 m1 50 40.01</span> +<span class="co">## 39 m1 75 40.09</span> +<span class="co">## 40 m1 75 33.85</span> +<span class="co">## 41 m1 100 31.04</span> +<span class="co">## 42 m1 100 33.13</span> +<span class="co">## 43 m1 120 25.15</span> +<span class="co">## 44 m1 120 33.31</span></code></pre> <p>Next we specify the degradation model: The parent compound degrades with simple first-order kinetics (SFO) to one metabolite named m1, which also degrades with SFO kinetics.</p> <p>The call to mkinmod returns a degradation model. The differential equations represented in R code can be found in the character vector <code>$diffs</code> of the <code>mkinmod</code> object. If a C compiler (gcc) is installed and functional, the differential equation model will be compiled from auto-generated C code.</p> <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">SFO_SFO</span><span class="op">$</span><span class="va">diffs</span><span class="op">)</span></code></pre></div> -<pre><code>## parent -## "d_parent = - k_parent * parent" -## m1 -## "d_m1 = + f_parent_to_m1 * k_parent * parent - k_m1 * m1"</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">SFO_SFO</span><span class="op">$</span><span class="va">diffs</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## parent </span> +<span class="co">## "d_parent = - k_parent * parent" </span> +<span class="co">## m1 </span> +<span class="co">## "d_m1 = + f_parent_to_m1 * k_parent * parent - k_m1 * m1"</span></code></pre> <p>We do the fitting without progress report (<code>quiet = TRUE</code>).</p> <div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE): Observations with value -## of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE): Observations with value</span> +<span class="co">## of zero were removed from the data</span></code></pre> <p>A plot of the fit including a residual plot for both observed variables is obtained using the <code>plot_sep</code> method for <code>mkinfit</code> objects, which shows separate graphs for all compounds and their residuals.</p> <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_D_files/figure-html/plot-1.png" width="768"></p> <p>Confidence intervals for the parameter estimates are obtained using the <code>mkinparplot</code> function.</p> <div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> @@ -184,134 +189,134 @@ <p><img src="FOCUS_D_files/figure-html/plot_2-1.png" width="768"></p> <p>A comprehensive report of the results is obtained using the <code>summary</code> method for <code>mkinfit</code> objects.</p> <div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:28 2021 -## Date of summary: Wed Mar 31 19:18:29 2021 -## -## Equations: -## d_parent/dt = - k_parent * parent -## d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1 -## -## Model predictions using solution type analytical -## -## Fitted using 401 model solutions performed in 0.159 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 100.7500 state -## k_parent 0.1000 deparm -## k_m1 0.1001 deparm -## f_parent_to_m1 0.5000 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 100.750000 -Inf Inf -## log_k_parent -2.302585 -Inf Inf -## log_k_m1 -2.301586 -Inf Inf -## f_parent_qlogis 0.000000 -Inf Inf -## -## Fixed parameter values: -## value type -## m1_0 0 state -## -## -## Warning(s): -## Observations with value of zero were removed from the data -## -## Results: -## -## AIC BIC logLik -## 204.4486 212.6365 -97.22429 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 99.60000 1.57000 96.4000 102.8000 -## log_k_parent -2.31600 0.04087 -2.3990 -2.2330 -## log_k_m1 -5.24700 0.13320 -5.5180 -4.9770 -## f_parent_qlogis 0.05792 0.08926 -0.1237 0.2395 -## sigma 3.12600 0.35850 2.3960 3.8550 -## -## Parameter correlation: -## parent_0 log_k_parent log_k_m1 f_parent_qlogis sigma -## parent_0 1.000e+00 5.174e-01 -1.688e-01 -5.471e-01 -1.172e-06 -## log_k_parent 5.174e-01 1.000e+00 -3.263e-01 -5.426e-01 -8.483e-07 -## log_k_m1 -1.688e-01 -3.263e-01 1.000e+00 7.478e-01 8.205e-07 -## f_parent_qlogis -5.471e-01 -5.426e-01 7.478e-01 1.000e+00 1.305e-06 -## sigma -1.172e-06 -8.483e-07 8.205e-07 1.305e-06 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 99.600000 63.430 2.298e-36 96.400000 1.028e+02 -## k_parent 0.098700 24.470 4.955e-23 0.090820 1.073e-01 -## k_m1 0.005261 7.510 6.165e-09 0.004012 6.898e-03 -## f_parent_to_m1 0.514500 23.070 3.104e-22 0.469100 5.596e-01 -## sigma 3.126000 8.718 2.235e-10 2.396000 3.855e+00 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 6.398 4 15 -## parent 6.459 2 7 -## m1 4.690 2 8 -## -## Resulting formation fractions: -## ff -## parent_m1 0.5145 -## parent_sink 0.4855 -## -## Estimated disappearance times: -## DT50 DT90 -## parent 7.023 23.33 -## m1 131.761 437.70 -## -## Data: -## time variable observed predicted residual -## 0 parent 99.46 99.59848 -1.385e-01 -## 0 parent 102.04 99.59848 2.442e+00 -## 1 parent 93.50 90.23787 3.262e+00 -## 1 parent 92.50 90.23787 2.262e+00 -## 3 parent 63.23 74.07319 -1.084e+01 -## 3 parent 68.99 74.07319 -5.083e+00 -## 7 parent 52.32 49.91207 2.408e+00 -## 7 parent 55.13 49.91207 5.218e+00 -## 14 parent 27.27 25.01258 2.257e+00 -## 14 parent 26.64 25.01258 1.627e+00 -## 21 parent 11.50 12.53462 -1.035e+00 -## 21 parent 11.64 12.53462 -8.946e-01 -## 35 parent 2.85 3.14787 -2.979e-01 -## 35 parent 2.91 3.14787 -2.379e-01 -## 50 parent 0.69 0.71624 -2.624e-02 -## 50 parent 0.63 0.71624 -8.624e-02 -## 75 parent 0.05 0.06074 -1.074e-02 -## 75 parent 0.06 0.06074 -7.382e-04 -## 1 m1 4.84 4.80296 3.704e-02 -## 1 m1 5.64 4.80296 8.370e-01 -## 3 m1 12.91 13.02400 -1.140e-01 -## 3 m1 12.96 13.02400 -6.400e-02 -## 7 m1 22.97 25.04476 -2.075e+00 -## 7 m1 24.47 25.04476 -5.748e-01 -## 14 m1 41.69 36.69003 5.000e+00 -## 14 m1 33.21 36.69003 -3.480e+00 -## 21 m1 44.37 41.65310 2.717e+00 -## 21 m1 46.44 41.65310 4.787e+00 -## 35 m1 41.22 43.31313 -2.093e+00 -## 35 m1 37.95 43.31313 -5.363e+00 -## 50 m1 41.19 41.21832 -2.832e-02 -## 50 m1 40.01 41.21832 -1.208e+00 -## 75 m1 40.09 36.44704 3.643e+00 -## 75 m1 33.85 36.44704 -2.597e+00 -## 100 m1 31.04 31.98162 -9.416e-01 -## 100 m1 33.13 31.98162 1.148e+00 -## 120 m1 25.15 28.78984 -3.640e+00 -## 120 m1 33.31 28.78984 4.520e+00</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:18 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:18 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - k_parent * parent</span> +<span class="co">## d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 401 model solutions performed in 0.145 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 100.7500 state</span> +<span class="co">## k_parent 0.1000 deparm</span> +<span class="co">## k_m1 0.1001 deparm</span> +<span class="co">## f_parent_to_m1 0.5000 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 100.750000 -Inf Inf</span> +<span class="co">## log_k_parent -2.302585 -Inf Inf</span> +<span class="co">## log_k_m1 -2.301586 -Inf Inf</span> +<span class="co">## f_parent_qlogis 0.000000 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## value type</span> +<span class="co">## m1_0 0 state</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## Warning(s): </span> +<span class="co">## Observations with value of zero were removed from the data</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 204.4486 212.6365 -97.22429</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 99.60000 1.57000 96.4000 102.8000</span> +<span class="co">## log_k_parent -2.31600 0.04087 -2.3990 -2.2330</span> +<span class="co">## log_k_m1 -5.24700 0.13320 -5.5180 -4.9770</span> +<span class="co">## f_parent_qlogis 0.05792 0.08926 -0.1237 0.2395</span> +<span class="co">## sigma 3.12600 0.35850 2.3960 3.8550</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_k_parent log_k_m1 f_parent_qlogis sigma</span> +<span class="co">## parent_0 1.000e+00 5.174e-01 -1.688e-01 -5.471e-01 -1.172e-06</span> +<span class="co">## log_k_parent 5.174e-01 1.000e+00 -3.263e-01 -5.426e-01 -8.483e-07</span> +<span class="co">## log_k_m1 -1.688e-01 -3.263e-01 1.000e+00 7.478e-01 8.205e-07</span> +<span class="co">## f_parent_qlogis -5.471e-01 -5.426e-01 7.478e-01 1.000e+00 1.305e-06</span> +<span class="co">## sigma -1.172e-06 -8.483e-07 8.205e-07 1.305e-06 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 99.600000 63.430 2.298e-36 96.400000 1.028e+02</span> +<span class="co">## k_parent 0.098700 24.470 4.955e-23 0.090820 1.073e-01</span> +<span class="co">## k_m1 0.005261 7.510 6.165e-09 0.004012 6.898e-03</span> +<span class="co">## f_parent_to_m1 0.514500 23.070 3.104e-22 0.469100 5.596e-01</span> +<span class="co">## sigma 3.126000 8.718 2.235e-10 2.396000 3.855e+00</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 6.398 4 15</span> +<span class="co">## parent 6.459 2 7</span> +<span class="co">## m1 4.690 2 8</span> +<span class="co">## </span> +<span class="co">## Resulting formation fractions:</span> +<span class="co">## ff</span> +<span class="co">## parent_m1 0.5145</span> +<span class="co">## parent_sink 0.4855</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90</span> +<span class="co">## parent 7.023 23.33</span> +<span class="co">## m1 131.761 437.70</span> +<span class="co">## </span> +<span class="co">## Data:</span> +<span class="co">## time variable observed predicted residual</span> +<span class="co">## 0 parent 99.46 99.59848 -1.385e-01</span> +<span class="co">## 0 parent 102.04 99.59848 2.442e+00</span> +<span class="co">## 1 parent 93.50 90.23787 3.262e+00</span> +<span class="co">## 1 parent 92.50 90.23787 2.262e+00</span> +<span class="co">## 3 parent 63.23 74.07319 -1.084e+01</span> +<span class="co">## 3 parent 68.99 74.07319 -5.083e+00</span> +<span class="co">## 7 parent 52.32 49.91207 2.408e+00</span> +<span class="co">## 7 parent 55.13 49.91207 5.218e+00</span> +<span class="co">## 14 parent 27.27 25.01258 2.257e+00</span> +<span class="co">## 14 parent 26.64 25.01258 1.627e+00</span> +<span class="co">## 21 parent 11.50 12.53462 -1.035e+00</span> +<span class="co">## 21 parent 11.64 12.53462 -8.946e-01</span> +<span class="co">## 35 parent 2.85 3.14787 -2.979e-01</span> +<span class="co">## 35 parent 2.91 3.14787 -2.379e-01</span> +<span class="co">## 50 parent 0.69 0.71624 -2.624e-02</span> +<span class="co">## 50 parent 0.63 0.71624 -8.624e-02</span> +<span class="co">## 75 parent 0.05 0.06074 -1.074e-02</span> +<span class="co">## 75 parent 0.06 0.06074 -7.382e-04</span> +<span class="co">## 1 m1 4.84 4.80296 3.704e-02</span> +<span class="co">## 1 m1 5.64 4.80296 8.370e-01</span> +<span class="co">## 3 m1 12.91 13.02400 -1.140e-01</span> +<span class="co">## 3 m1 12.96 13.02400 -6.400e-02</span> +<span class="co">## 7 m1 22.97 25.04476 -2.075e+00</span> +<span class="co">## 7 m1 24.47 25.04476 -5.748e-01</span> +<span class="co">## 14 m1 41.69 36.69003 5.000e+00</span> +<span class="co">## 14 m1 33.21 36.69003 -3.480e+00</span> +<span class="co">## 21 m1 44.37 41.65310 2.717e+00</span> +<span class="co">## 21 m1 46.44 41.65310 4.787e+00</span> +<span class="co">## 35 m1 41.22 43.31313 -2.093e+00</span> +<span class="co">## 35 m1 37.95 43.31313 -5.363e+00</span> +<span class="co">## 50 m1 41.19 41.21832 -2.832e-02</span> +<span class="co">## 50 m1 40.01 41.21832 -1.208e+00</span> +<span class="co">## 75 m1 40.09 36.44704 3.643e+00</span> +<span class="co">## 75 m1 33.85 36.44704 -2.597e+00</span> +<span class="co">## 100 m1 31.04 31.98162 -9.416e-01</span> +<span class="co">## 100 m1 33.13 31.98162 1.148e+00</span> +<span class="co">## 120 m1 25.15 28.78984 -3.640e+00</span> +<span class="co">## 120 m1 33.31 28.78984 4.520e+00</span></code></pre> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> @@ -323,11 +328,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -336,5 +343,7 @@ + + </body> </html> diff --git a/docs/articles/FOCUS_D_files/figure-html/plot-1.png b/docs/articles/FOCUS_D_files/figure-html/plot-1.png Binary files differindex c3a5d56e..f0b51c1f 100644 --- a/docs/articles/FOCUS_D_files/figure-html/plot-1.png +++ b/docs/articles/FOCUS_D_files/figure-html/plot-1.png diff --git a/docs/articles/FOCUS_D_files/figure-html/plot_2-1.png b/docs/articles/FOCUS_D_files/figure-html/plot_2-1.png Binary files differindex 42e48dee..f6180470 100644 --- a/docs/articles/FOCUS_D_files/figure-html/plot_2-1.png +++ b/docs/articles/FOCUS_D_files/figure-html/plot_2-1.png diff --git a/docs/articles/FOCUS_L.html b/docs/articles/FOCUS_L.html index 7074816c..9efea93a 100644 --- a/docs/articles/FOCUS_L.html +++ b/docs/articles/FOCUS_L.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,30 +99,30 @@ - </header><script src="FOCUS_L_files/header-attrs-2.7/header-attrs.js"></script><script src="FOCUS_L_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="FOCUS_L_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Example evaluation of FOCUS Laboratory Data L1 to L3</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 17 November 2016 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 17 November 2016 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/FOCUS_L.rmd"><code>vignettes/FOCUS_L.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_L.rmd" class="external-link"><code>vignettes/FOCUS_L.rmd</code></a></small> <div class="hidden name"><code>FOCUS_L.rmd</code></div> </div> -<div id="laboratory-data-l1" class="section level1"> -<h1 class="hasAnchor"> -<a href="#laboratory-data-l1" class="anchor"></a>Laboratory Data L1</h1> +<div class="section level2"> +<h2 id="laboratory-data-l1">Laboratory Data L1<a class="anchor" aria-label="anchor" href="#laboratory-data-l1"></a> +</h2> <p>The following code defines example dataset L1 from the FOCUS kinetics report, p. 284:</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="va">FOCUS_2006_L1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html">data.frame</a></span><span class="op">(</span> - t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">5</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">21</span>, <span class="fl">30</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>, - parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">88.3</span>, <span class="fl">91.4</span>, <span class="fl">85.6</span>, <span class="fl">84.5</span>, <span class="fl">78.9</span>, <span class="fl">77.6</span>, +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<span class="va">FOCUS_2006_L1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">5</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">21</span>, <span class="fl">30</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>, + parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">88.3</span>, <span class="fl">91.4</span>, <span class="fl">85.6</span>, <span class="fl">84.5</span>, <span class="fl">78.9</span>, <span class="fl">77.6</span>, <span class="fl">72.0</span>, <span class="fl">71.9</span>, <span class="fl">50.3</span>, <span class="fl">59.4</span>, <span class="fl">47.0</span>, <span class="fl">45.1</span>, <span class="fl">27.7</span>, <span class="fl">27.3</span>, <span class="fl">10.0</span>, <span class="fl">10.4</span>, <span class="fl">2.9</span>, <span class="fl">4.0</span><span class="op">)</span><span class="op">)</span> <span class="va">FOCUS_2006_L1_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L1</span><span class="op">)</span></code></pre></div> @@ -125,94 +130,94 @@ <p>Since mkin version 0.9-32 (July 2014), we can use shorthand notation like <code>"SFO"</code> for parent only degradation models. The following two lines fit the model and produce the summary report of the model fit. This covers the numerical analysis given in the FOCUS report.</p> <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.L1.SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_L1_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.L1.SFO</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:31 2021 -## Date of summary: Wed Mar 31 19:18:31 2021 -## -## Equations: -## d_parent/dt = - k_parent * parent -## -## Model predictions using solution type analytical -## -## Fitted using 133 model solutions performed in 0.032 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 89.85 state -## k_parent 0.10 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 89.850000 -Inf Inf -## log_k_parent -2.302585 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 93.88778 96.5589 -43.94389 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 92.470 1.28200 89.740 95.200 -## log_k_parent -2.347 0.03763 -2.428 -2.267 -## sigma 2.780 0.46330 1.792 3.767 -## -## Parameter correlation: -## parent_0 log_k_parent sigma -## parent_0 1.000e+00 6.186e-01 -1.516e-09 -## log_k_parent 6.186e-01 1.000e+00 -3.124e-09 -## sigma -1.516e-09 -3.124e-09 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 92.47000 72.13 8.824e-21 89.74000 95.2000 -## k_parent 0.09561 26.57 2.487e-14 0.08824 0.1036 -## sigma 2.78000 6.00 1.216e-05 1.79200 3.7670 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 3.424 2 7 -## parent 3.424 2 7 -## -## Estimated disappearance times: -## DT50 DT90 -## parent 7.249 24.08 -## -## Data: -## time variable observed predicted residual -## 0 parent 88.3 92.471 -4.1710 -## 0 parent 91.4 92.471 -1.0710 -## 1 parent 85.6 84.039 1.5610 -## 1 parent 84.5 84.039 0.4610 -## 2 parent 78.9 76.376 2.5241 -## 2 parent 77.6 76.376 1.2241 -## 3 parent 72.0 69.412 2.5884 -## 3 parent 71.9 69.412 2.4884 -## 5 parent 50.3 57.330 -7.0301 -## 5 parent 59.4 57.330 2.0699 -## 7 parent 47.0 47.352 -0.3515 -## 7 parent 45.1 47.352 -2.2515 -## 14 parent 27.7 24.247 3.4528 -## 14 parent 27.3 24.247 3.0528 -## 21 parent 10.0 12.416 -2.4163 -## 21 parent 10.4 12.416 -2.0163 -## 30 parent 2.9 5.251 -2.3513 -## 30 parent 4.0 5.251 -1.2513</code></pre> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.SFO</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:22 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:22 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - k_parent * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 133 model solutions performed in 0.032 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 89.85 state</span> +<span class="co">## k_parent 0.10 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 89.850000 -Inf Inf</span> +<span class="co">## log_k_parent -2.302585 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 93.88778 96.5589 -43.94389</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 92.470 1.28200 89.740 95.200</span> +<span class="co">## log_k_parent -2.347 0.03763 -2.428 -2.267</span> +<span class="co">## sigma 2.780 0.46330 1.792 3.767</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_k_parent sigma</span> +<span class="co">## parent_0 1.000e+00 6.186e-01 -1.516e-09</span> +<span class="co">## log_k_parent 6.186e-01 1.000e+00 -3.124e-09</span> +<span class="co">## sigma -1.516e-09 -3.124e-09 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 92.47000 72.13 8.824e-21 89.74000 95.2000</span> +<span class="co">## k_parent 0.09561 26.57 2.487e-14 0.08824 0.1036</span> +<span class="co">## sigma 2.78000 6.00 1.216e-05 1.79200 3.7670</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 3.424 2 7</span> +<span class="co">## parent 3.424 2 7</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90</span> +<span class="co">## parent 7.249 24.08</span> +<span class="co">## </span> +<span class="co">## Data:</span> +<span class="co">## time variable observed predicted residual</span> +<span class="co">## 0 parent 88.3 92.471 -4.1710</span> +<span class="co">## 0 parent 91.4 92.471 -1.0710</span> +<span class="co">## 1 parent 85.6 84.039 1.5610</span> +<span class="co">## 1 parent 84.5 84.039 0.4610</span> +<span class="co">## 2 parent 78.9 76.376 2.5241</span> +<span class="co">## 2 parent 77.6 76.376 1.2241</span> +<span class="co">## 3 parent 72.0 69.412 2.5884</span> +<span class="co">## 3 parent 71.9 69.412 2.4884</span> +<span class="co">## 5 parent 50.3 57.330 -7.0301</span> +<span class="co">## 5 parent 59.4 57.330 2.0699</span> +<span class="co">## 7 parent 47.0 47.352 -0.3515</span> +<span class="co">## 7 parent 45.1 47.352 -2.2515</span> +<span class="co">## 14 parent 27.7 24.247 3.4528</span> +<span class="co">## 14 parent 27.3 24.247 3.0528</span> +<span class="co">## 21 parent 10.0 12.416 -2.4163</span> +<span class="co">## 21 parent 10.4 12.416 -2.0163</span> +<span class="co">## 30 parent 2.9 5.251 -2.3513</span> +<span class="co">## 30 parent 4.0 5.251 -1.2513</span></code></pre> <p>A plot of the fit is obtained with the plot function for mkinfit objects.</p> <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">m.L1.SFO</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - SFO"</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L1.SFO</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - SFO"</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-4-1.png" width="576"></p> <p>The residual plot can be easily obtained by</p> <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> @@ -221,566 +226,566 @@ <p>For comparison, the FOMC model is fitted as well, and the <span class="math inline">\(\chi^2\)</span> error level is checked.</p> <div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.L1.FOMC</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_L1_mkin</span>, quiet<span class="op">=</span><span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit("FOMC", FOCUS_2006_L1_mkin, quiet = TRUE): Optimisation did not converge: -## false convergence (8)</code></pre> +<pre><code><span class="co">## Warning in mkinfit("FOMC", FOCUS_2006_L1_mkin, quiet = TRUE): Optimisation did not converge:</span> +<span class="co">## false convergence (8)</span></code></pre> <div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - FOMC"</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - FOMC"</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-6-1.png" width="576"></p> <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:32 2021 -## Date of summary: Wed Mar 31 19:18:32 2021 -## -## Equations: -## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent -## -## Model predictions using solution type analytical -## -## Fitted using 369 model solutions performed in 0.083 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 89.85 state -## alpha 1.00 deparm -## beta 10.00 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 89.850000 -Inf Inf -## log_alpha 0.000000 -Inf Inf -## log_beta 2.302585 -Inf Inf -## -## Fixed parameter values: -## None -## -## -## Warning(s): -## Optimisation did not converge: -## false convergence (8) -## -## Results: -## -## AIC BIC logLik -## 95.88781 99.44929 -43.9439 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 92.47 1.2820 89.720 95.220 -## log_alpha 13.78 NaN NaN NaN -## log_beta 16.13 NaN NaN NaN -## sigma 2.78 0.4598 1.794 3.766 -## -## Parameter correlation: -## parent_0 log_alpha log_beta sigma -## parent_0 1.0000000 NaN NaN 0.0001671 -## log_alpha NaN 1 NaN NaN -## log_beta NaN NaN 1 NaN -## sigma 0.0001671 NaN NaN 1.0000000 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 9.247e+01 NA NA 89.720 95.220 -## alpha 9.658e+05 NA NA NA NA -## beta 1.010e+07 NA NA NA NA -## sigma 2.780e+00 NA NA 1.794 3.766 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 3.619 3 6 -## parent 3.619 3 6 -## -## Estimated disappearance times: -## DT50 DT90 DT50back -## parent 7.25 24.08 7.25</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:22 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:22 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 369 model solutions performed in 0.082 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 89.85 state</span> +<span class="co">## alpha 1.00 deparm</span> +<span class="co">## beta 10.00 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 89.850000 -Inf Inf</span> +<span class="co">## log_alpha 0.000000 -Inf Inf</span> +<span class="co">## log_beta 2.302585 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## Warning(s): </span> +<span class="co">## Optimisation did not converge:</span> +<span class="co">## false convergence (8)</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 95.88781 99.44929 -43.9439</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 92.47 1.2820 89.720 95.220</span> +<span class="co">## log_alpha 13.78 NaN NaN NaN</span> +<span class="co">## log_beta 16.13 NaN NaN NaN</span> +<span class="co">## sigma 2.78 0.4598 1.794 3.766</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_alpha log_beta sigma</span> +<span class="co">## parent_0 1.0000000 NaN NaN 0.0001671</span> +<span class="co">## log_alpha NaN 1 NaN NaN</span> +<span class="co">## log_beta NaN NaN 1 NaN</span> +<span class="co">## sigma 0.0001671 NaN NaN 1.0000000</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.247e+01 NA NA 89.720 95.220</span> +<span class="co">## alpha 9.658e+05 NA NA NA NA</span> +<span class="co">## beta 1.010e+07 NA NA NA NA</span> +<span class="co">## sigma 2.780e+00 NA NA 1.794 3.766</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 3.619 3 6</span> +<span class="co">## parent 3.619 3 6</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90 DT50back</span> +<span class="co">## parent 7.25 24.08 7.25</span></code></pre> <p>We get a warning that the default optimisation algorithm <code>Port</code> did not converge, which is an indication that the model is overparameterised, <em>i.e.</em> contains too many parameters that are ill-defined as a consequence.</p> <p>And in fact, due to the higher number of parameters, and the lower number of degrees of freedom of the fit, the <span class="math inline">\(\chi^2\)</span> error level is actually higher for the FOMC model (3.6%) than for the SFO model (3.4%). Additionally, the parameters <code>log_alpha</code> and <code>log_beta</code> internally fitted in the model have excessive confidence intervals, that span more than 25 orders of magnitude (!) when backtransformed to the scale of <code>alpha</code> and <code>beta</code>. Also, the t-test for significant difference from zero does not indicate such a significant difference, with p-values greater than 0.1, and finally, the parameter correlation of <code>log_alpha</code> and <code>log_beta</code> is 1.000, clearly indicating that the model is overparameterised.</p> <p>The <span class="math inline">\(\chi^2\)</span> error levels reported in Appendix 3 and Appendix 7 to the FOCUS kinetics report are rounded to integer percentages and partly deviate by one percentage point from the results calculated by mkin. The reason for this is not known. However, mkin gives the same <span class="math inline">\(\chi^2\)</span> error levels as the kinfit package and the calculation routines of the kinfit package have been extensively compared to the results obtained by the KinGUI software, as documented in the kinfit package vignette. KinGUI was the first widely used standard package in this field. Also, the calculation of <span class="math inline">\(\chi^2\)</span> error levels was compared with KinGUII, CAKE and DegKin manager in a project sponsored by the German Umweltbundesamt <span class="citation">(Ranke 2014)</span>.</p> </div> -<div id="laboratory-data-l2" class="section level1"> -<h1 class="hasAnchor"> -<a href="#laboratory-data-l2" class="anchor"></a>Laboratory Data L2</h1> +<div class="section level2"> +<h2 id="laboratory-data-l2">Laboratory Data L2<a class="anchor" aria-label="anchor" href="#laboratory-data-l2"></a> +</h2> <p>The following code defines example dataset L2 from the FOCUS kinetics report, p. 287:</p> <div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">FOCUS_2006_L2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html">data.frame</a></span><span class="op">(</span> - t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>, - parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">96.1</span>, <span class="fl">91.8</span>, <span class="fl">41.4</span>, <span class="fl">38.7</span>, +<code class="sourceCode R"><span class="va">FOCUS_2006_L2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>, + parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">96.1</span>, <span class="fl">91.8</span>, <span class="fl">41.4</span>, <span class="fl">38.7</span>, <span class="fl">19.3</span>, <span class="fl">22.3</span>, <span class="fl">4.6</span>, <span class="fl">4.6</span>, <span class="fl">2.6</span>, <span class="fl">1.2</span>, <span class="fl">0.3</span>, <span class="fl">0.6</span><span class="op">)</span><span class="op">)</span> <span class="va">FOCUS_2006_L2_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L2</span><span class="op">)</span></code></pre></div> -<div id="sfo-fit-for-l2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#sfo-fit-for-l2" class="anchor"></a>SFO fit for L2</h2> +<div class="section level3"> +<h3 id="sfo-fit-for-l2">SFO fit for L2<a class="anchor" aria-label="anchor" href="#sfo-fit-for-l2"></a> +</h3> <p>Again, the SFO model is fitted and the result is plotted. The residual plot can be obtained simply by adding the argument <code>show_residuals</code> to the plot command.</p> <div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.L2.SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet<span class="op">=</span><span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">m.L2.SFO</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.SFO</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L2 - SFO"</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-8-1.png" width="672"></p> <p>The <span class="math inline">\(\chi^2\)</span> error level of 14% suggests that the model does not fit very well. This is also obvious from the plots of the fit, in which we have included the residual plot.</p> <p>In the FOCUS kinetics report, it is stated that there is no apparent systematic error observed from the residual plot up to the measured DT90 (approximately at day 5), and there is an underestimation beyond that point.</p> <p>We may add that it is difficult to judge the random nature of the residuals just from the three samplings at days 0, 1 and 3. Also, it is not clear <em>a priori</em> why a consistent underestimation after the approximate DT90 should be irrelevant. However, this can be rationalised by the fact that the FOCUS fate models generally only implement SFO kinetics.</p> </div> -<div id="fomc-fit-for-l2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#fomc-fit-for-l2" class="anchor"></a>FOMC fit for L2</h2> +<div class="section level3"> +<h3 id="fomc-fit-for-l2">FOMC fit for L2<a class="anchor" aria-label="anchor" href="#fomc-fit-for-l2"></a> +</h3> <p>For comparison, the FOMC model is fitted as well, and the <span class="math inline">\(\chi^2\)</span> error level is checked.</p> <div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.L2.FOMC</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L2 - FOMC"</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-9-1.png" width="672"></p> <div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:32 2021 -## Date of summary: Wed Mar 31 19:18:32 2021 -## -## Equations: -## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent -## -## Model predictions using solution type analytical -## -## Fitted using 239 model solutions performed in 0.05 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 93.95 state -## alpha 1.00 deparm -## beta 10.00 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 93.950000 -Inf Inf -## log_alpha 0.000000 -Inf Inf -## log_beta 2.302585 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 61.78966 63.72928 -26.89483 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 93.7700 1.6130 90.05000 97.4900 -## log_alpha 0.3180 0.1559 -0.04149 0.6776 -## log_beta 0.2102 0.2493 -0.36460 0.7850 -## sigma 2.2760 0.4645 1.20500 3.3470 -## -## Parameter correlation: -## parent_0 log_alpha log_beta sigma -## parent_0 1.000e+00 -1.151e-01 -2.085e-01 -7.828e-09 -## log_alpha -1.151e-01 1.000e+00 9.741e-01 -1.602e-07 -## log_beta -2.085e-01 9.741e-01 1.000e+00 -1.372e-07 -## sigma -7.828e-09 -1.602e-07 -1.372e-07 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 93.770 58.120 4.267e-12 90.0500 97.490 -## alpha 1.374 6.414 1.030e-04 0.9594 1.969 -## beta 1.234 4.012 1.942e-03 0.6945 2.192 -## sigma 2.276 4.899 5.977e-04 1.2050 3.347 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 6.205 3 3 -## parent 6.205 3 3 -## -## Estimated disappearance times: -## DT50 DT90 DT50back -## parent 0.8092 5.356 1.612</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:23 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:23 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 239 model solutions performed in 0.049 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 93.95 state</span> +<span class="co">## alpha 1.00 deparm</span> +<span class="co">## beta 10.00 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 93.950000 -Inf Inf</span> +<span class="co">## log_alpha 0.000000 -Inf Inf</span> +<span class="co">## log_beta 2.302585 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 61.78966 63.72928 -26.89483</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 93.7700 1.6130 90.05000 97.4900</span> +<span class="co">## log_alpha 0.3180 0.1559 -0.04149 0.6776</span> +<span class="co">## log_beta 0.2102 0.2493 -0.36460 0.7850</span> +<span class="co">## sigma 2.2760 0.4645 1.20500 3.3470</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_alpha log_beta sigma</span> +<span class="co">## parent_0 1.000e+00 -1.151e-01 -2.085e-01 -7.828e-09</span> +<span class="co">## log_alpha -1.151e-01 1.000e+00 9.741e-01 -1.602e-07</span> +<span class="co">## log_beta -2.085e-01 9.741e-01 1.000e+00 -1.372e-07</span> +<span class="co">## sigma -7.828e-09 -1.602e-07 -1.372e-07 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 93.770 58.120 4.267e-12 90.0500 97.490</span> +<span class="co">## alpha 1.374 6.414 1.030e-04 0.9594 1.969</span> +<span class="co">## beta 1.234 4.012 1.942e-03 0.6945 2.192</span> +<span class="co">## sigma 2.276 4.899 5.977e-04 1.2050 3.347</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 6.205 3 3</span> +<span class="co">## parent 6.205 3 3</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90 DT50back</span> +<span class="co">## parent 0.8092 5.356 1.612</span></code></pre> <p>The error level at which the <span class="math inline">\(\chi^2\)</span> test passes is much lower in this case. Therefore, the FOMC model provides a better description of the data, as less experimental error has to be assumed in order to explain the data.</p> </div> -<div id="dfop-fit-for-l2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#dfop-fit-for-l2" class="anchor"></a>DFOP fit for L2</h2> +<div class="section level3"> +<h3 id="dfop-fit-for-l2">DFOP fit for L2<a class="anchor" aria-label="anchor" href="#dfop-fit-for-l2"></a> +</h3> <p>Fitting the four parameter DFOP model further reduces the <span class="math inline">\(\chi^2\)</span> error level.</p> <div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.L2.DFOP</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L2 - DFOP"</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-10-1.png" width="672"></p> <div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:33 2021 -## Date of summary: Wed Mar 31 19:18:33 2021 -## -## Equations: -## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -## * parent -## -## Model predictions using solution type analytical -## -## Fitted using 581 model solutions performed in 0.134 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 93.95 state -## k1 0.10 deparm -## k2 0.01 deparm -## g 0.50 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 93.950000 -Inf Inf -## log_k1 -2.302585 -Inf Inf -## log_k2 -4.605170 -Inf Inf -## g_qlogis 0.000000 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 52.36695 54.79148 -21.18347 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 93.950 9.998e-01 91.5900 96.3100 -## log_k1 3.112 1.842e+03 -4353.0000 4359.0000 -## log_k2 -1.088 6.285e-02 -1.2370 -0.9394 -## g_qlogis -0.399 9.946e-02 -0.6342 -0.1638 -## sigma 1.414 2.886e-01 0.7314 2.0960 -## -## Parameter correlation: -## parent_0 log_k1 log_k2 g_qlogis sigma -## parent_0 1.000e+00 6.783e-07 -3.390e-10 2.665e-01 -2.967e-10 -## log_k1 6.783e-07 1.000e+00 1.116e-04 -2.196e-04 -1.031e-05 -## log_k2 -3.390e-10 1.116e-04 1.000e+00 -7.903e-01 2.917e-09 -## g_qlogis 2.665e-01 -2.196e-04 -7.903e-01 1.000e+00 -4.408e-09 -## sigma -2.967e-10 -1.031e-05 2.917e-09 -4.408e-09 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 93.9500 9.397e+01 2.036e-12 91.5900 96.3100 -## k1 22.4800 5.553e-04 4.998e-01 0.0000 Inf -## k2 0.3369 1.591e+01 4.697e-07 0.2904 0.3909 -## g 0.4016 1.680e+01 3.238e-07 0.3466 0.4591 -## sigma 1.4140 4.899e+00 8.776e-04 0.7314 2.0960 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 2.53 4 2 -## parent 2.53 4 2 -## -## Estimated disappearance times: -## DT50 DT90 DT50back DT50_k1 DT50_k2 -## parent 0.5335 5.311 1.599 0.03084 2.058</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:23 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:23 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="co">## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="co">## * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 581 model solutions performed in 0.131 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 93.95 state</span> +<span class="co">## k1 0.10 deparm</span> +<span class="co">## k2 0.01 deparm</span> +<span class="co">## g 0.50 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 93.950000 -Inf Inf</span> +<span class="co">## log_k1 -2.302585 -Inf Inf</span> +<span class="co">## log_k2 -4.605170 -Inf Inf</span> +<span class="co">## g_qlogis 0.000000 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 52.36695 54.79148 -21.18347</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 93.950 9.998e-01 91.5900 96.3100</span> +<span class="co">## log_k1 3.112 1.842e+03 -4353.0000 4359.0000</span> +<span class="co">## log_k2 -1.088 6.285e-02 -1.2370 -0.9394</span> +<span class="co">## g_qlogis -0.399 9.946e-02 -0.6342 -0.1638</span> +<span class="co">## sigma 1.414 2.886e-01 0.7314 2.0960</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_k1 log_k2 g_qlogis sigma</span> +<span class="co">## parent_0 1.000e+00 6.783e-07 -3.390e-10 2.665e-01 -2.967e-10</span> +<span class="co">## log_k1 6.783e-07 1.000e+00 1.116e-04 -2.196e-04 -1.031e-05</span> +<span class="co">## log_k2 -3.390e-10 1.116e-04 1.000e+00 -7.903e-01 2.917e-09</span> +<span class="co">## g_qlogis 2.665e-01 -2.196e-04 -7.903e-01 1.000e+00 -4.408e-09</span> +<span class="co">## sigma -2.967e-10 -1.031e-05 2.917e-09 -4.408e-09 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 93.9500 9.397e+01 2.036e-12 91.5900 96.3100</span> +<span class="co">## k1 22.4800 5.553e-04 4.998e-01 0.0000 Inf</span> +<span class="co">## k2 0.3369 1.591e+01 4.697e-07 0.2904 0.3909</span> +<span class="co">## g 0.4016 1.680e+01 3.238e-07 0.3466 0.4591</span> +<span class="co">## sigma 1.4140 4.899e+00 8.776e-04 0.7314 2.0960</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 2.53 4 2</span> +<span class="co">## parent 2.53 4 2</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="co">## parent 0.5335 5.311 1.599 0.03084 2.058</span></code></pre> <p>Here, the DFOP model is clearly the best-fit model for dataset L2 based on the chi^2 error level criterion. However, the failure to calculate the covariance matrix indicates that the parameter estimates correlate excessively. Therefore, the FOMC model may be preferred for this dataset.</p> </div> </div> -<div id="laboratory-data-l3" class="section level1"> -<h1 class="hasAnchor"> -<a href="#laboratory-data-l3" class="anchor"></a>Laboratory Data L3</h1> +<div class="section level2"> +<h2 id="laboratory-data-l3">Laboratory Data L3<a class="anchor" aria-label="anchor" href="#laboratory-data-l3"></a> +</h2> <p>The following code defines example dataset L3 from the FOCUS kinetics report, p. 290.</p> <div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">FOCUS_2006_L3</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html">data.frame</a></span><span class="op">(</span> - t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>, - parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">97.8</span>, <span class="fl">60</span>, <span class="fl">51</span>, <span class="fl">43</span>, <span class="fl">35</span>, <span class="fl">22</span>, <span class="fl">15</span>, <span class="fl">12</span><span class="op">)</span><span class="op">)</span> +<code class="sourceCode R"><span class="va">FOCUS_2006_L3</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>, + parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">97.8</span>, <span class="fl">60</span>, <span class="fl">51</span>, <span class="fl">43</span>, <span class="fl">35</span>, <span class="fl">22</span>, <span class="fl">15</span>, <span class="fl">12</span><span class="op">)</span><span class="op">)</span> <span class="va">FOCUS_2006_L3_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L3</span><span class="op">)</span></code></pre></div> -<div id="fit-multiple-models" class="section level2"> -<h2 class="hasAnchor"> -<a href="#fit-multiple-models" class="anchor"></a>Fit multiple models</h2> +<div class="section level3"> +<h3 id="fit-multiple-models">Fit multiple models<a class="anchor" aria-label="anchor" href="#fit-multiple-models"></a> +</h3> <p>As of mkin version 0.9-39 (June 2015), we can fit several models to one or more datasets in one call to the function <code>mmkin</code>. The datasets have to be passed in a list, in this case a named list holding only the L3 dataset prepared above.</p> <div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="co"># Only use one core here, not to offend the CRAN checks</span> -<span class="va">mm.L3</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, - <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="st">"FOCUS L3"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L3_mkin</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">)</span></code></pre></div> +<span class="va">mm.L3</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, + <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS L3"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L3_mkin</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-12-1.png" width="700"></p> <p>The <span class="math inline">\(\chi^2\)</span> error level of 21% as well as the plot suggest that the SFO model does not fit very well. The FOMC model performs better, with an error level at which the <span class="math inline">\(\chi^2\)</span> test passes of 7%. Fitting the four parameter DFOP model further reduces the <span class="math inline">\(\chi^2\)</span> error level considerably.</p> </div> -<div id="accessing-mmkin-objects" class="section level2"> -<h2 class="hasAnchor"> -<a href="#accessing-mmkin-objects" class="anchor"></a>Accessing mmkin objects</h2> +<div class="section level3"> +<h3 id="accessing-mmkin-objects">Accessing mmkin objects<a class="anchor" aria-label="anchor" href="#accessing-mmkin-objects"></a> +</h3> <p>The objects returned by mmkin are arranged like a matrix, with models as a row index and datasets as a column index.</p> <p>We can extract the summary and plot for <em>e.g.</em> the DFOP fit, using square brackets for indexing which will result in the use of the summary and plot functions working on mkinfit objects.</p> <div class="sourceCode" id="cb24"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:33 2021 -## Date of summary: Wed Mar 31 19:18:33 2021 -## -## Equations: -## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -## * parent -## -## Model predictions using solution type analytical -## -## Fitted using 376 model solutions performed in 0.081 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 97.80 state -## k1 0.10 deparm -## k2 0.01 deparm -## g 0.50 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 97.800000 -Inf Inf -## log_k1 -2.302585 -Inf Inf -## log_k2 -4.605170 -Inf Inf -## g_qlogis 0.000000 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 32.97732 33.37453 -11.48866 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 97.7500 1.01900 94.5000 101.000000 -## log_k1 -0.6612 0.10050 -0.9812 -0.341300 -## log_k2 -4.2860 0.04322 -4.4230 -4.148000 -## g_qlogis -0.1739 0.05270 -0.3416 -0.006142 -## sigma 1.0170 0.25430 0.2079 1.827000 -## -## Parameter correlation: -## parent_0 log_k1 log_k2 g_qlogis sigma -## parent_0 1.000e+00 1.732e-01 2.282e-02 4.009e-01 -9.664e-08 -## log_k1 1.732e-01 1.000e+00 4.945e-01 -5.809e-01 7.147e-07 -## log_k2 2.282e-02 4.945e-01 1.000e+00 -6.812e-01 1.022e-06 -## g_qlogis 4.009e-01 -5.809e-01 -6.812e-01 1.000e+00 -7.926e-07 -## sigma -9.664e-08 7.147e-07 1.022e-06 -7.926e-07 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 97.75000 95.960 1.248e-06 94.50000 101.00000 -## k1 0.51620 9.947 1.081e-03 0.37490 0.71090 -## k2 0.01376 23.140 8.840e-05 0.01199 0.01579 -## g 0.45660 34.920 2.581e-05 0.41540 0.49850 -## sigma 1.01700 4.000 1.400e-02 0.20790 1.82700 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 2.225 4 4 -## parent 2.225 4 4 -## -## Estimated disappearance times: -## DT50 DT90 DT50back DT50_k1 DT50_k2 -## parent 7.464 123 37.03 1.343 50.37 -## -## Data: -## time variable observed predicted residual -## 0 parent 97.8 97.75 0.05396 -## 3 parent 60.0 60.45 -0.44933 -## 7 parent 51.0 49.44 1.56338 -## 14 parent 43.0 43.84 -0.83632 -## 30 parent 35.0 35.15 -0.14707 -## 60 parent 22.0 23.26 -1.25919 -## 91 parent 15.0 15.18 -0.18181 -## 120 parent 12.0 10.19 1.81395</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:24 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:24 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="co">## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="co">## * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 376 model solutions performed in 0.079 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 97.80 state</span> +<span class="co">## k1 0.10 deparm</span> +<span class="co">## k2 0.01 deparm</span> +<span class="co">## g 0.50 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 97.800000 -Inf Inf</span> +<span class="co">## log_k1 -2.302585 -Inf Inf</span> +<span class="co">## log_k2 -4.605170 -Inf Inf</span> +<span class="co">## g_qlogis 0.000000 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 32.97732 33.37453 -11.48866</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 97.7500 1.01900 94.5000 101.000000</span> +<span class="co">## log_k1 -0.6612 0.10050 -0.9812 -0.341300</span> +<span class="co">## log_k2 -4.2860 0.04322 -4.4230 -4.148000</span> +<span class="co">## g_qlogis -0.1739 0.05270 -0.3416 -0.006142</span> +<span class="co">## sigma 1.0170 0.25430 0.2079 1.827000</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_k1 log_k2 g_qlogis sigma</span> +<span class="co">## parent_0 1.000e+00 1.732e-01 2.282e-02 4.009e-01 -9.664e-08</span> +<span class="co">## log_k1 1.732e-01 1.000e+00 4.945e-01 -5.809e-01 7.147e-07</span> +<span class="co">## log_k2 2.282e-02 4.945e-01 1.000e+00 -6.812e-01 1.022e-06</span> +<span class="co">## g_qlogis 4.009e-01 -5.809e-01 -6.812e-01 1.000e+00 -7.926e-07</span> +<span class="co">## sigma -9.664e-08 7.147e-07 1.022e-06 -7.926e-07 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.75000 95.960 1.248e-06 94.50000 101.00000</span> +<span class="co">## k1 0.51620 9.947 1.081e-03 0.37490 0.71090</span> +<span class="co">## k2 0.01376 23.140 8.840e-05 0.01199 0.01579</span> +<span class="co">## g 0.45660 34.920 2.581e-05 0.41540 0.49850</span> +<span class="co">## sigma 1.01700 4.000 1.400e-02 0.20790 1.82700</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 2.225 4 4</span> +<span class="co">## parent 2.225 4 4</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="co">## parent 7.464 123 37.03 1.343 50.37</span> +<span class="co">## </span> +<span class="co">## Data:</span> +<span class="co">## time variable observed predicted residual</span> +<span class="co">## 0 parent 97.8 97.75 0.05396</span> +<span class="co">## 3 parent 60.0 60.45 -0.44933</span> +<span class="co">## 7 parent 51.0 49.44 1.56338</span> +<span class="co">## 14 parent 43.0 43.84 -0.83632</span> +<span class="co">## 30 parent 35.0 35.15 -0.14707</span> +<span class="co">## 60 parent 22.0 23.26 -1.25919</span> +<span class="co">## 91 parent 15.0 15.18 -0.18181</span> +<span class="co">## 120 parent 12.0 10.19 1.81395</span></code></pre> <div class="sourceCode" id="cb26"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-13-1.png" width="700"></p> <p>Here, a look to the model plot, the confidence intervals of the parameters and the correlation matrix suggest that the parameter estimates are reliable, and the DFOP model can be used as the best-fit model based on the <span class="math inline">\(\chi^2\)</span> error level criterion for laboratory data L3.</p> <p>This is also an example where the standard t-test for the parameter <code>g_ilr</code> is misleading, as it tests for a significant difference from zero. In this case, zero appears to be the correct value for this parameter, and the confidence interval for the backtransformed parameter <code>g</code> is quite narrow.</p> </div> </div> -<div id="laboratory-data-l4" class="section level1"> -<h1 class="hasAnchor"> -<a href="#laboratory-data-l4" class="anchor"></a>Laboratory Data L4</h1> +<div class="section level2"> +<h2 id="laboratory-data-l4">Laboratory Data L4<a class="anchor" aria-label="anchor" href="#laboratory-data-l4"></a> +</h2> <p>The following code defines example dataset L4 from the FOCUS kinetics report, p. 293:</p> <div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">FOCUS_2006_L4</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html">data.frame</a></span><span class="op">(</span> - t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>, - parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">96.6</span>, <span class="fl">96.3</span>, <span class="fl">94.3</span>, <span class="fl">88.8</span>, <span class="fl">74.9</span>, <span class="fl">59.9</span>, <span class="fl">53.5</span>, <span class="fl">49.0</span><span class="op">)</span><span class="op">)</span> +<code class="sourceCode R"><span class="va">FOCUS_2006_L4</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>, + parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">96.6</span>, <span class="fl">96.3</span>, <span class="fl">94.3</span>, <span class="fl">88.8</span>, <span class="fl">74.9</span>, <span class="fl">59.9</span>, <span class="fl">53.5</span>, <span class="fl">49.0</span><span class="op">)</span><span class="op">)</span> <span class="va">FOCUS_2006_L4_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L4</span><span class="op">)</span></code></pre></div> <p>Fits of the SFO and FOMC models, plots and summaries are produced below:</p> <div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="co"># Only use one core here, not to offend the CRAN checks</span> -<span class="va">mm.L4</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, - <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="st">"FOCUS L4"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L4_mkin</span><span class="op">)</span>, +<span class="va">mm.L4</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, + <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS L4"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L4_mkin</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">)</span></code></pre></div> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_L_files/figure-html/unnamed-chunk-15-1.png" width="700"></p> <p>The <span class="math inline">\(\chi^2\)</span> error level of 3.3% as well as the plot suggest that the SFO model fits very well. The error level at which the <span class="math inline">\(\chi^2\)</span> test passes is slightly lower for the FOMC model. However, the difference appears negligible.</p> <div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:34 2021 -## Date of summary: Wed Mar 31 19:18:34 2021 -## -## Equations: -## d_parent/dt = - k_parent * parent -## -## Model predictions using solution type analytical -## -## Fitted using 142 model solutions performed in 0.03 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 96.6 state -## k_parent 0.1 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 96.600000 -Inf Inf -## log_k_parent -2.302585 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 47.12133 47.35966 -20.56067 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 96.440 1.69900 92.070 100.800 -## log_k_parent -5.030 0.07059 -5.211 -4.848 -## sigma 3.162 0.79050 1.130 5.194 -## -## Parameter correlation: -## parent_0 log_k_parent sigma -## parent_0 1.000e+00 5.938e-01 3.387e-07 -## log_k_parent 5.938e-01 1.000e+00 5.830e-07 -## sigma 3.387e-07 5.830e-07 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 96.440000 56.77 1.604e-08 92.070000 1.008e+02 -## k_parent 0.006541 14.17 1.578e-05 0.005455 7.842e-03 -## sigma 3.162000 4.00 5.162e-03 1.130000 5.194e+00 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 3.287 2 6 -## parent 3.287 2 6 -## -## Estimated disappearance times: -## DT50 DT90 -## parent 106 352</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:25 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:25 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - k_parent * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 142 model solutions performed in 0.029 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 96.6 state</span> +<span class="co">## k_parent 0.1 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 96.600000 -Inf Inf</span> +<span class="co">## log_k_parent -2.302585 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 47.12133 47.35966 -20.56067</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 96.440 1.69900 92.070 100.800</span> +<span class="co">## log_k_parent -5.030 0.07059 -5.211 -4.848</span> +<span class="co">## sigma 3.162 0.79050 1.130 5.194</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_k_parent sigma</span> +<span class="co">## parent_0 1.000e+00 5.938e-01 3.387e-07</span> +<span class="co">## log_k_parent 5.938e-01 1.000e+00 5.830e-07</span> +<span class="co">## sigma 3.387e-07 5.830e-07 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.440000 56.77 1.604e-08 92.070000 1.008e+02</span> +<span class="co">## k_parent 0.006541 14.17 1.578e-05 0.005455 7.842e-03</span> +<span class="co">## sigma 3.162000 4.00 5.162e-03 1.130000 5.194e+00</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 3.287 2 6</span> +<span class="co">## parent 3.287 2 6</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90</span> +<span class="co">## parent 106 352</span></code></pre> <div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> -<pre><code>## mkin version used for fitting: 1.0.4 -## R version used for fitting: 4.0.4 -## Date of fit: Wed Mar 31 19:18:34 2021 -## Date of summary: Wed Mar 31 19:18:34 2021 -## -## Equations: -## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent -## -## Model predictions using solution type analytical -## -## Fitted using 224 model solutions performed in 0.046 s -## -## Error model: Constant variance -## -## Error model algorithm: OLS -## -## Starting values for parameters to be optimised: -## value type -## parent_0 96.6 state -## alpha 1.0 deparm -## beta 10.0 deparm -## -## Starting values for the transformed parameters actually optimised: -## value lower upper -## parent_0 96.600000 -Inf Inf -## log_alpha 0.000000 -Inf Inf -## log_beta 2.302585 -Inf Inf -## -## Fixed parameter values: -## None -## -## Results: -## -## AIC BIC logLik -## 40.37255 40.69032 -16.18628 -## -## Optimised, transformed parameters with symmetric confidence intervals: -## Estimate Std. Error Lower Upper -## parent_0 99.1400 1.2670 95.6300 102.7000 -## log_alpha -0.3506 0.2616 -1.0770 0.3756 -## log_beta 4.1740 0.3938 3.0810 5.2670 -## sigma 1.8300 0.4575 0.5598 3.1000 -## -## Parameter correlation: -## parent_0 log_alpha log_beta sigma -## parent_0 1.000e+00 -4.696e-01 -5.543e-01 -2.468e-07 -## log_alpha -4.696e-01 1.000e+00 9.889e-01 2.478e-08 -## log_beta -5.543e-01 9.889e-01 1.000e+00 5.211e-08 -## sigma -2.468e-07 2.478e-08 5.211e-08 1.000e+00 -## -## Backtransformed parameters: -## Confidence intervals for internally transformed parameters are asymmetric. -## t-test (unrealistically) based on the assumption of normal distribution -## for estimators of untransformed parameters. -## Estimate t value Pr(>t) Lower Upper -## parent_0 99.1400 78.250 7.993e-08 95.6300 102.700 -## alpha 0.7042 3.823 9.365e-03 0.3407 1.456 -## beta 64.9800 2.540 3.201e-02 21.7800 193.900 -## sigma 1.8300 4.000 8.065e-03 0.5598 3.100 -## -## FOCUS Chi2 error levels in percent: -## err.min n.optim df -## All data 2.029 3 5 -## parent 2.029 3 5 -## -## Estimated disappearance times: -## DT50 DT90 DT50back -## parent 108.9 1644 494.9</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## mkin version used for fitting: 1.1.0 </span> +<span class="co">## R version used for fitting: 4.1.2 </span> +<span class="co">## Date of fit: Wed Mar 2 13:44:25 2022 </span> +<span class="co">## Date of summary: Wed Mar 2 13:44:25 2022 </span> +<span class="co">## </span> +<span class="co">## Equations:</span> +<span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="co">## </span> +<span class="co">## Model predictions using solution type analytical </span> +<span class="co">## </span> +<span class="co">## Fitted using 224 model solutions performed in 0.045 s</span> +<span class="co">## </span> +<span class="co">## Error model: Constant variance </span> +<span class="co">## </span> +<span class="co">## Error model algorithm: OLS </span> +<span class="co">## </span> +<span class="co">## Starting values for parameters to be optimised:</span> +<span class="co">## value type</span> +<span class="co">## parent_0 96.6 state</span> +<span class="co">## alpha 1.0 deparm</span> +<span class="co">## beta 10.0 deparm</span> +<span class="co">## </span> +<span class="co">## Starting values for the transformed parameters actually optimised:</span> +<span class="co">## value lower upper</span> +<span class="co">## parent_0 96.600000 -Inf Inf</span> +<span class="co">## log_alpha 0.000000 -Inf Inf</span> +<span class="co">## log_beta 2.302585 -Inf Inf</span> +<span class="co">## </span> +<span class="co">## Fixed parameter values:</span> +<span class="co">## None</span> +<span class="co">## </span> +<span class="co">## Results:</span> +<span class="co">## </span> +<span class="co">## AIC BIC logLik</span> +<span class="co">## 40.37255 40.69032 -16.18628</span> +<span class="co">## </span> +<span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="co">## Estimate Std. Error Lower Upper</span> +<span class="co">## parent_0 99.1400 1.2670 95.6300 102.7000</span> +<span class="co">## log_alpha -0.3506 0.2616 -1.0770 0.3756</span> +<span class="co">## log_beta 4.1740 0.3938 3.0810 5.2670</span> +<span class="co">## sigma 1.8300 0.4575 0.5598 3.1000</span> +<span class="co">## </span> +<span class="co">## Parameter correlation:</span> +<span class="co">## parent_0 log_alpha log_beta sigma</span> +<span class="co">## parent_0 1.000e+00 -4.696e-01 -5.543e-01 -2.468e-07</span> +<span class="co">## log_alpha -4.696e-01 1.000e+00 9.889e-01 2.478e-08</span> +<span class="co">## log_beta -5.543e-01 9.889e-01 1.000e+00 5.211e-08</span> +<span class="co">## sigma -2.468e-07 2.478e-08 5.211e-08 1.000e+00</span> +<span class="co">## </span> +<span class="co">## Backtransformed parameters:</span> +<span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="co">## for estimators of untransformed parameters.</span> +<span class="co">## Estimate t value Pr(>t) Lower Upper</span> +<span class="co">## parent_0 99.1400 78.250 7.993e-08 95.6300 102.700</span> +<span class="co">## alpha 0.7042 3.823 9.365e-03 0.3407 1.456</span> +<span class="co">## beta 64.9800 2.540 3.201e-02 21.7800 193.900</span> +<span class="co">## sigma 1.8300 4.000 8.065e-03 0.5598 3.100</span> +<span class="co">## </span> +<span class="co">## FOCUS Chi2 error levels in percent:</span> +<span class="co">## err.min n.optim df</span> +<span class="co">## All data 2.029 3 5</span> +<span class="co">## parent 2.029 3 5</span> +<span class="co">## </span> +<span class="co">## Estimated disappearance times:</span> +<span class="co">## DT50 DT90 DT50back</span> +<span class="co">## parent 108.9 1644 494.9</span></code></pre> </div> -<div id="references" class="section level1 unnumbered"> -<h1 class="hasAnchor"> -<a href="#references" class="anchor"></a>References</h1> +<div class="section level2"> +<h2 class="unnumbered" id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> <div id="refs" class="references hanging-indent"> <div id="ref-ranke2014"> <p>Ranke, Johannes. 2014. “Prüfung und Validierung von Modellierungssoftware als Alternative zu ModelMaker 4.0.” Umweltbundesamt Projektnummer 27452.</p> @@ -800,11 +805,13 @@ <footer><div class="copyright"> - 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-<!--[if lt IE 9]> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Articles • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-article-index"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -71,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -86,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -97,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -111,30 +58,23 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Articles</h1> @@ -144,45 +84,43 @@ <h3>All vignettes</h3> <p class="section-desc"></p> - <dl> - <dt><a href="FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a></dt> - <dd></dt> - <dt><a href="FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a></dt> - <dd></dt> - <dt><a href="mkin.html">Introduction to mkin</a></dt> - <dd></dt> - <dt><a href="twa.html">Calculation of time weighted average concentrations with mkin</a></dt> - <dd></dt> - <dt><a href="web_only/FOCUS_Z.html">Example evaluation of FOCUS dataset Z</a></dt> - <dd></dt> - <dt><a href="web_only/NAFTA_examples.html">Evaluation of example datasets from Attachment 1 to the US EPA SOP for the NAFTA guidance</a></dt> - <dd></dt> - <dt><a href="web_only/benchmarks.html">Benchmark timings for mkin</a></dt> - <dd></dt> - <dt><a href="web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a></dt> - <dd></dt> - </dl> - </div> + <dl><dt><a href="FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a></dt> + <dd> + </dd><dt><a href="FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a></dt> + <dd> + </dd><dt><a href="mkin.html">Introduction to mkin</a></dt> + <dd> + </dd><dt><a href="twa.html">Calculation of time weighted average concentrations with mkin</a></dt> + <dd> + </dd><dt><a href="web_only/FOCUS_Z.html">Example evaluation of FOCUS dataset Z</a></dt> + <dd> + </dd><dt><a href="web_only/NAFTA_examples.html">Evaluation of example datasets from Attachment 1 to the US EPA SOP for the NAFTA guidance</a></dt> + <dd> + </dd><dt><a href="web_only/benchmarks.html">Benchmark timings for mkin</a></dt> + <dd> + </dd><dt><a href="web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a></dt> + <dd> + </dd><dt><a href="web_only/dimethenamid_2018.html">Example evaluations of the dimethenamid data from 2018</a></dt> + <dd> + </dd></dl></div> </div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/articles/mkin.html b/docs/articles/mkin.html index a0fccc16..e51356ee 100644 --- a/docs/articles/mkin.html +++ b/docs/articles/mkin.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,28 +99,28 @@ - </header><script src="mkin_files/header-attrs-2.7/header-attrs.js"></script><script src="mkin_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="mkin_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Introduction to mkin</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 15 February 2021 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 15 February 2021 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/mkin.rmd"><code>vignettes/mkin.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/mkin.rmd" class="external-link"><code>vignettes/mkin.rmd</code></a></small> <div class="hidden name"><code>mkin.rmd</code></div> </div> -<p><a href="https://www.jrwb.de">Wissenschaftlicher Berater, Kronacher Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br><a href="http://chem.uft.uni-bremen.de/ranke/">Privatdozent at the University of Bremen</a></p> -<div id="abstract" class="section level1"> -<h1 class="hasAnchor"> -<a href="#abstract" class="anchor"></a>Abstract</h1> +<p><a href="https://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br> Privatdozent at the University of Freiburg</p> +<div class="section level2"> +<h2 id="abstract">Abstract<a class="anchor" aria-label="anchor" href="#abstract"></a> +</h2> <p>In the regulatory evaluation of chemical substances like plant protection products (pesticides), biocides and other chemicals, degradation data play an important role. For the evaluation of pesticide degradation experiments, detailed guidance has been developed, based on nonlinear optimisation. The <code>R</code> add-on package <code>mkin</code> implements fitting some of the models recommended in this guidance from within R and calculates some statistical measures for data series within one or more compartments, for parent and metabolites.</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="co"># Define the kinetic model</span> <span class="va">m_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>, M1 <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>, @@ -124,12 +129,12 @@ <span class="co"># Produce model predictions using some arbitrary parameters</span> -<span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span> +<span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span> <span class="va">d_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO_SFO_SFO</span>, - <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.03</span>, - f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>, k_M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">100</span>, - f_M1_to_M2 <span class="op">=</span> <span class="fl">0.9</span>, k_M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">50</span><span class="op">)</span>, - <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, + <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.03</span>, + f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>, k_M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">100</span>, + f_M1_to_M2 <span class="op">=</span> <span class="fl">0.9</span>, k_M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">50</span><span class="op">)</span>, + <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span> <span class="co"># Generate a dataset by adding normally distributed errors with</span> @@ -142,31 +147,31 @@ <span class="va">f_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_SFO_SFO_SFO</span>, <span class="va">d_SFO_SFO_SFO_err</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="co"># Plot the results separately for parent and metabolites</span> -<span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_SFO_SFO_SFO</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_SFO_SFO_SFO</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></code></pre></div> <p><img src="mkin_files/figure-html/unnamed-chunk-2-1.png" width="768"></p> </div> -<div id="background" class="section level1"> -<h1 class="hasAnchor"> -<a href="#background" class="anchor"></a>Background</h1> +<div class="section level2"> +<h2 id="background">Background<a class="anchor" aria-label="anchor" href="#background"></a> +</h2> <p>The <code>mkin</code> package <span class="citation">(Ranke 2021)</span> implements the approach to degradation kinetics recommended in the kinetics report provided by the FOrum for Co-ordination of pesticide fate models and their USe <span class="citation">(FOCUS Work Group on Degradation Kinetics 2006, 2014)</span>. It covers data series describing the decline of one compound, data series with transformation products (commonly termed metabolites) and data series for more than one compartment. It is possible to include back reactions. Therefore, equilibrium reactions and equilibrium partitioning can be specified, although this often leads to an overparameterisation of the model.</p> <p>When the first <code>mkin</code> code was published in 2010, the most commonly used tools for fitting more complex kinetic degradation models to experimental data were KinGUI <span class="citation">(Schäfer et al. 2007)</span>, a MATLAB based tool with a graphical user interface that was specifically tailored to the task and included some output as proposed by the FOCUS Kinetics Workgroup, and ModelMaker, a general purpose compartment based tool providing infrastructure for fitting dynamic simulation models based on differential equations to data.</p> -<p>The ‘mkin’ code was first uploaded to the BerliOS development platform. When this was taken down, the version control history was imported into the R-Forge site (see <em>e.g.</em> <a href="https://cgit.jrwb.de/mkin/commit/?id=30cbb4092f6d2d3beff5800603374a0d009ad770">the initial commit on 11 May 2010</a>), where the code is still being updated.</p> +<p>The ‘mkin’ code was first uploaded to the BerliOS development platform. When this was taken down, the version control history was imported into the R-Forge site (see <em>e.g.</em> <a href="https://cgit.jrwb.de/mkin/commit/?id=30cbb4092f6d2d3beff5800603374a0d009ad770" class="external-link">the initial commit on 11 May 2010</a>), where the code is still being updated.</p> <p>At that time, the R package <code>FME</code> (Flexible Modelling Environment) <span class="citation">(Soetaert and Petzoldt 2010)</span> was already available, and provided a good basis for developing a package specifically tailored to the task. The remaining challenge was to make it as easy as possible for the users (including the author of this vignette) to specify the system of differential equations and to include the output requested by the FOCUS guidance, such as the <span class="math inline">\(\chi^2\)</span> error level as defined in this guidance.</p> <p>Also, <code>mkin</code> introduced using analytical solutions for parent only kinetics for improved optimization speed. Later, Eigenvalue based solutions were introduced to <code>mkin</code> for the case of linear differential equations (<em>i.e.</em> where the FOMC or DFOP models were not used for the parent compound), greatly improving the optimization speed for these cases. This, has become somehow obsolete, as the use of compiled code described below gives even faster execution times.</p> <p>The possibility to specify back-reactions and a biphasic model (SFORB) for metabolites were present in <code>mkin</code> from the very beginning.</p> -<div id="derived-software-tools" class="section level2"> -<h2 class="hasAnchor"> -<a href="#derived-software-tools" class="anchor"></a>Derived software tools</h2> +<div class="section level3"> +<h3 id="derived-software-tools">Derived software tools<a class="anchor" aria-label="anchor" href="#derived-software-tools"></a> +</h3> <p>Soon after the publication of <code>mkin</code>, two derived tools were published, namely KinGUII (developed at Bayer Crop Science) and CAKE (commissioned to Tessella by Syngenta), which added a graphical user interface (GUI), and added fitting by iteratively reweighted least squares (IRLS) and characterisation of likely parameter distributions by Markov Chain Monte Carlo (MCMC) sampling.</p> <p>CAKE focuses on a smooth use experience, sacrificing some flexibility in the model definition, originally allowing only two primary metabolites in parallel. The current version 3.4 of CAKE released in May 2020 uses a scheme for up to six metabolites in a flexible arrangement and supports biphasic modelling of metabolites, but does not support back-reactions (non-instantaneous equilibria).</p> <p>KinGUI offers an even more flexible widget for specifying complex kinetic models. Back-reactions (non-instantaneous equilibria) were supported early on, but until 2014, only simple first-order models could be specified for transformation products. Starting with KinGUII version 2.1, biphasic modelling of metabolites was also available in KinGUII.</p> -<p>A further graphical user interface (GUI) that has recently been brought to a decent degree of maturity is the browser based GUI named <code>gmkin</code>. Please see its <a href="https://pkgdown.jrwb.de/gmkin/">documentation page</a> and <a href="https://pkgdown.jrwb.de/gmkin/articles/gmkin_manual.html">manual</a> for further information.</p> +<p>A further graphical user interface (GUI) that has recently been brought to a decent degree of maturity is the browser based GUI named <code>gmkin</code>. Please see its <a href="https://pkgdown.jrwb.de/gmkin/" class="external-link">documentation page</a> and <a href="https://pkgdown.jrwb.de/gmkin/articles/gmkin_manual.html" class="external-link">manual</a> for further information.</p> <p>A comparison of scope, usability and numerical results obtained with these tools has been recently been published by <span class="citation">Ranke, Wöltjen, and Meinecke (2018)</span>.</p> </div> </div> -<div id="unique-features" class="section level1"> -<h1 class="hasAnchor"> -<a href="#unique-features" class="anchor"></a>Unique features</h1> +<div class="section level2"> +<h2 id="unique-features">Unique features<a class="anchor" aria-label="anchor" href="#unique-features"></a> +</h2> <p>Currently, the main unique features available in <code>mkin</code> are</p> <ul> <li>the <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">speed increase</a> by using compiled code when a compiler is present,</li> @@ -177,66 +182,66 @@ </ul> <p>The iteratively reweighted least squares fitting of different variances for each variable as introduced by <span class="citation">Gao et al. (2011)</span> has been available in mkin since <a href="https://pkgdown.jrwb.de/mkin/news/index.html#mkin-0-9-22-2013-10-26">version 0.9-22</a>. With <a href="https://pkgdown.jrwb.de/mkin/news/index.html#mkin-0-9-49-5-2019-07-04">release 0.9.49.5</a>, the IRLS algorithm has been complemented by direct or step-wise maximisation of the likelihood function, which makes it possible not only to fit the variance by variable error model but also a <a href="https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html">two-component error model</a> inspired by error models developed in analytical chemistry <span class="citation">(Ranke and Meinecke 2019)</span>.</p> </div> -<div id="internal-parameter-transformations" class="section level1"> -<h1 class="hasAnchor"> -<a href="#internal-parameter-transformations" class="anchor"></a>Internal parameter transformations</h1> +<div class="section level2"> +<h2 id="internal-parameter-transformations">Internal parameter transformations<a class="anchor" aria-label="anchor" href="#internal-parameter-transformations"></a> +</h2> <p>For rate constants, the log transformation is used, as proposed by Bates and Watts <span class="citation">(1988, 77, 149)</span>. Approximate intervals are constructed for the transformed rate constants <span class="citation">(compare Bates and Watts 1988, 135)</span>, <em>i.e.</em> for their logarithms. Confidence intervals for the rate constants are then obtained using the appropriate backtransformation using the exponential function.</p> <p>In the first version of <code>mkin</code> allowing for specifying models using formation fractions, a home-made reparameterisation was used in order to ensure that the sum of formation fractions would not exceed unity.</p> <p>This method is still used in the current version of KinGUII (v2.1 from April 2014), with a modification that allows for fixing the pathway to sink to zero. CAKE uses penalties in the objective function in order to enforce this constraint.</p> <p>In 2012, an alternative reparameterisation of the formation fractions was proposed together with René Lehmann <span class="citation">(Ranke and Lehmann 2012)</span>, based on isometric logratio transformation (ILR). The aim was to improve the validity of the linear approximation of the objective function during the parameter estimation procedure as well as in the subsequent calculation of parameter confidence intervals. In the current version of mkin, a logit transformation is used for parameters that are bound between 0 and 1, such as the g parameter of the DFOP model.</p> -<div id="confidence-intervals-based-on-transformed-parameters" class="section level2"> -<h2 class="hasAnchor"> -<a href="#confidence-intervals-based-on-transformed-parameters" class="anchor"></a>Confidence intervals based on transformed parameters</h2> +<div class="section level3"> +<h3 id="confidence-intervals-based-on-transformed-parameters">Confidence intervals based on transformed parameters<a class="anchor" aria-label="anchor" href="#confidence-intervals-based-on-transformed-parameters"></a> +</h3> <p>In the first attempt at providing improved parameter confidence intervals introduced to <code>mkin</code> in 2013, confidence intervals obtained from FME on the transformed parameters were simply all backtransformed one by one to yield asymmetric confidence intervals for the backtransformed parameters.</p> <p>However, while there is a 1:1 relation between the rate constants in the model and the transformed parameters fitted in the model, the parameters obtained by the isometric logratio transformation are calculated from the set of formation fractions that quantify the paths to each of the compounds formed from a specific parent compound, and no such 1:1 relation exists.</p> <p>Therefore, parameter confidence intervals for formation fractions obtained with this method only appear valid for the case of a single transformation product, where currently the logit transformation is used for the formation fraction.</p> <p>The confidence intervals obtained by backtransformation for the cases where a 1:1 relation between transformed and original parameter exist are considered by the author of this vignette to be more accurate than those obtained using a re-estimation of the Hessian matrix after backtransformation, as implemented in the FME package.</p> </div> -<div id="parameter-t-test-based-on-untransformed-parameters" class="section level2"> -<h2 class="hasAnchor"> -<a href="#parameter-t-test-based-on-untransformed-parameters" class="anchor"></a>Parameter t-test based on untransformed parameters</h2> +<div class="section level3"> +<h3 id="parameter-t-test-based-on-untransformed-parameters">Parameter t-test based on untransformed parameters<a class="anchor" aria-label="anchor" href="#parameter-t-test-based-on-untransformed-parameters"></a> +</h3> <p>The standard output of many nonlinear regression software packages includes the results from a test for significant difference from zero for all parameters. Such a test is also recommended to check the validity of rate constants in the FOCUS guidance <span class="citation">(FOCUS Work Group on Degradation Kinetics 2014, 96ff)</span>.</p> <p>It has been argued that the precondition for this test, <em>i.e.</em> normal distribution of the estimator for the parameters, is not fulfilled in the case of nonlinear regression <span class="citation">(Ranke and Lehmann 2015)</span>. However, this test is commonly used by industry, consultants and national authorities in order to decide on the reliability of parameter estimates, based on the FOCUS guidance mentioned above. Therefore, the results of this one-sided t-test are included in the summary output from <code>mkin</code>.</p> <p>As it is not reasonable to test for significant difference of the transformed parameters (<em>e.g.</em> <span class="math inline">\(log(k)\)</span>) from zero, the t-test is calculated based on the model definition before parameter transformation, <em>i.e.</em> in a similar way as in packages that do not apply such an internal parameter transformation. A note is included in the <code>mkin</code> output, pointing to the fact that the t-test is based on the unjustified assumption of normal distribution of the parameter estimators.</p> </div> </div> -<div id="references" class="section level1"> -<h1 class="hasAnchor"> -<a href="#references" class="anchor"></a>References</h1> +<div class="section level2"> +<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> <!-- vim: set foldmethod=syntax: --> <div id="refs" class="references hanging-indent"> <div id="ref-bates1988"> <p>Bates, D., and D. Watts. 1988. <em>Nonlinear Regression and Its Applications</em>. Wiley-Interscience.</p> </div> <div id="ref-FOCUS2006"> -<p>FOCUS Work Group on Degradation Kinetics. 2006. <em>Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration. Report of the Focus Work Group on Degradation Kinetics</em>. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> +<p>FOCUS Work Group on Degradation Kinetics. 2006. <em>Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration. Report of the Focus Work Group on Degradation Kinetics</em>. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> </div> <div id="ref-FOCUSkinetics2014"> -<p>———. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> +<p>———. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> </div> <div id="ref-gao11"> <p>Gao, Z., J. W. Green, J. Vanderborght, and W. Schmitt. 2011. “Improving Uncertainty Analysis in Kinetic Evaluations Using Iteratively Reweighted Least Squares.” Journal. <em>Environmental Science and Technology</em> 45: 4429–37.</p> </div> <div id="ref-pkg:mkin"> -<p>Ranke, J. 2021. <em>‘mkin‘: Kinetic Evaluation of Chemical Degradation Data</em>. <a href="https://CRAN.R-project.org/package=mkin">https://CRAN.R-project.org/package=mkin</a>.</p> +<p>Ranke, J. 2021. <em>‘mkin‘: Kinetic Evaluation of Chemical Degradation Data</em>. <a href="https://CRAN.R-project.org/package=mkin" class="external-link">https://CRAN.R-project.org/package=mkin</a>.</p> </div> <div id="ref-ranke2012"> <p>Ranke, J., and R. Lehmann. 2012. “Parameter Reliability in Kinetic Evaluation of Environmental Metabolism Data - Assessment and the Influence of Model Specification.” In <em>SETAC World 20-24 May</em>. Berlin.</p> </div> <div id="ref-ranke2015"> -<p>———. 2015. “To T-Test or Not to T-Test, That Is the Question.” In <em>XV Symposium on Pesticide Chemistry 2-4 September 2015</em>. Piacenza. <a href="http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf">http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf</a>.</p> +<p>———. 2015. “To T-Test or Not to T-Test, That Is the Question.” In <em>XV Symposium on Pesticide Chemistry 2-4 September 2015</em>. Piacenza. <a href="http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf" class="external-link">http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf</a>.</p> </div> <div id="ref-ranke2019"> -<p>Ranke, Johannes, and Stefan Meinecke. 2019. “Error Models for the Kinetic Evaluation of Chemical Degradation Data.” <em>Environments</em> 6 (12). <a href="https://doi.org/10.3390/environments6120124">https://doi.org/10.3390/environments6120124</a>.</p> +<p>Ranke, Johannes, and Stefan Meinecke. 2019. “Error Models for the Kinetic Evaluation of Chemical Degradation Data.” <em>Environments</em> 6 (12). <a href="https://doi.org/10.3390/environments6120124" class="external-link">https://doi.org/10.3390/environments6120124</a>.</p> </div> <div id="ref-ranke2018"> -<p>Ranke, Johannes, Janina Wöltjen, and Stefan Meinecke. 2018. “Comparison of Software Tools for Kinetic Evaluation of Chemical Degradation Data.” <em>Environmental Sciences Europe</em> 30 (1): 17. <a href="https://doi.org/10.1186/s12302-018-0145-1">https://doi.org/10.1186/s12302-018-0145-1</a>.</p> +<p>Ranke, Johannes, Janina Wöltjen, and Stefan Meinecke. 2018. “Comparison of Software Tools for Kinetic Evaluation of Chemical Degradation Data.” <em>Environmental Sciences Europe</em> 30 (1): 17. <a href="https://doi.org/10.1186/s12302-018-0145-1" class="external-link">https://doi.org/10.1186/s12302-018-0145-1</a>.</p> </div> <div id="ref-schaefer2007"> <p>Schäfer, D., B. Mikolasch, P. Rainbird, and B. Harvey. 2007. “KinGUI: A New Kinetic Software Tool for Evaluations According to FOCUS Degradation Kinetics.” In <em>Proceedings of the Xiii Symposium Pesticide Chemistry</em>, edited by Del Re A. A. M., Capri E., Fragoulis G., and Trevisan M., 916–23. Piacenza.</p> </div> <div id="ref-soetaert2010"> -<p>Soetaert, Karline, and Thomas Petzoldt. 2010. “Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME.” <em>Journal of Statistical Software</em> 33 (3): 1–28. <a href="https://www.jstatsoft.org/v33/i03/">https://www.jstatsoft.org/v33/i03/</a>.</p> +<p>Soetaert, Karline, and Thomas Petzoldt. 2010. “Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME.” <em>Journal of Statistical Software</em> 33 (3): 1–28. <a href="https://doi.org/10.18637/jss.v033.i03" class="external-link">https://doi.org/10.18637/jss.v033.i03</a>.</p> </div> </div> </div> @@ -253,11 +258,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -266,5 +273,7 @@ + + </body> </html> diff --git a/docs/articles/mkin_files/figure-html/unnamed-chunk-2-1.png b/docs/articles/mkin_files/figure-html/unnamed-chunk-2-1.png Binary files differindex 8a182047..63246387 100644 --- a/docs/articles/mkin_files/figure-html/unnamed-chunk-2-1.png +++ b/docs/articles/mkin_files/figure-html/unnamed-chunk-2-1.png diff --git a/docs/articles/twa.html b/docs/articles/twa.html index 167f60d3..5b1c333d 100644 --- a/docs/articles/twa.html +++ b/docs/articles/twa.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,15 +99,15 @@ - </header><script src="twa_files/header-attrs-2.7/header-attrs.js"></script><script src="twa_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="twa_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Calculation of time weighted average concentrations with mkin</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 18 September 2019 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 18 September 2019 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/twa.rmd"><code>vignettes/twa.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/twa.rmd" class="external-link"><code>vignettes/twa.rmd</code></a></small> <div class="hidden name"><code>twa.rmd</code></div> </div> @@ -140,10 +145,10 @@ <p><span class="math display">\[f_\textrm{twa} = \frac{1}{t} \left( \frac{1}{k_1} \left( 1 - e^{- k_1 t_b} \right) + \frac{e^{- k_1 t_b}}{k_2} \left( 1 - e^{- k_2 (t - t_b)} \right) \right) \]</span></p> -<p>Note that a method for calculating maximum moving window time weighted average concentrations for a model fitted by ‘mkinfit’ or from parent decline model parameters is included in the <code><a href="../reference/max_twa_parent.html">max_twa_parent()</a></code> function. If the same is needed for metabolites, the function <code><a href="https://pkgdown.jrwb.de/pfm/reference/max_twa.html">pfm::max_twa()</a></code> from the ‘pfm’ package can be used.</p> +<p>Note that a method for calculating maximum moving window time weighted average concentrations for a model fitted by ‘mkinfit’ or from parent decline model parameters is included in the <code><a href="../reference/max_twa_parent.html">max_twa_parent()</a></code> function. If the same is needed for metabolites, the function <code><a href="https://pkgdown.jrwb.de/pfm/reference/max_twa.html" class="external-link">pfm::max_twa()</a></code> from the ‘pfm’ package can be used.</p> <div id="refs" class="references hanging-indent"> <div id="ref-FOCUSkinetics2014"> -<p>FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> +<p>FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> </div> </div> </div> @@ -157,11 +162,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -170,5 +177,7 @@ + + </body> </html> diff --git a/docs/articles/web_only/FOCUS_Z.html b/docs/articles/web_only/FOCUS_Z.html index e4a6cb52..326fc121 100644 --- a/docs/articles/web_only/FOCUS_Z.html +++ b/docs/articles/web_only/FOCUS_Z.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,124 +99,124 @@ - </header><script src="FOCUS_Z_files/header-attrs-2.7/header-attrs.js"></script><script src="FOCUS_Z_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="FOCUS_Z_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Example evaluation of FOCUS dataset Z</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 16 January 2018 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 16 January 2018 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/web_only/FOCUS_Z.rmd"><code>vignettes/web_only/FOCUS_Z.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/FOCUS_Z.rmd" class="external-link"><code>vignettes/web_only/FOCUS_Z.rmd</code></a></small> <div class="hidden name"><code>FOCUS_Z.rmd</code></div> </div> -<p><a href="http://www.jrwb.de">Wissenschaftlicher Berater, Kronacher Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br><a href="http://chem.uft.uni-bremen.de/ranke">Privatdozent at the University of Bremen</a></p> -<div id="the-data" class="section level1"> -<h1 class="hasAnchor"> -<a href="#the-data" class="anchor"></a>The data</h1> +<p><a href="http://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br><a href="http://chem.uft.uni-bremen.de/ranke" class="external-link">Privatdozent at the University of Bremen</a></p> +<div class="section level2"> +<h2 id="the-data">The data<a class="anchor" aria-label="anchor" href="#the-data"></a> +</h2> <p>The following code defines the example dataset from Appendix 7 to the FOCUS kinetics report <span class="citation">(FOCUS Work Group on Degradation Kinetics 2014, 354)</span>.</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="va">LOD</span> <span class="op">=</span> <span class="fl">0.5</span> -<span class="va">FOCUS_2006_Z</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html">data.frame</a></span><span class="op">(</span> - t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">0.04</span>, <span class="fl">0.125</span>, <span class="fl">0.29</span>, <span class="fl">0.54</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">4</span>, <span class="fl">7</span>, <span class="fl">10</span>, <span class="fl">14</span>, <span class="fl">21</span>, +<span class="va">FOCUS_2006_Z</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">0.04</span>, <span class="fl">0.125</span>, <span class="fl">0.29</span>, <span class="fl">0.54</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">4</span>, <span class="fl">7</span>, <span class="fl">10</span>, <span class="fl">14</span>, <span class="fl">21</span>, <span class="fl">42</span>, <span class="fl">61</span>, <span class="fl">96</span>, <span class="fl">124</span><span class="op">)</span>, - Z0 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">100</span>, <span class="fl">81.7</span>, <span class="fl">70.4</span>, <span class="fl">51.1</span>, <span class="fl">41.2</span>, <span class="fl">6.6</span>, <span class="fl">4.6</span>, <span class="fl">3.9</span>, <span class="fl">4.6</span>, <span class="fl">4.3</span>, <span class="fl">6.8</span>, + Z0 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">100</span>, <span class="fl">81.7</span>, <span class="fl">70.4</span>, <span class="fl">51.1</span>, <span class="fl">41.2</span>, <span class="fl">6.6</span>, <span class="fl">4.6</span>, <span class="fl">3.9</span>, <span class="fl">4.6</span>, <span class="fl">4.3</span>, <span class="fl">6.8</span>, <span class="fl">2.9</span>, <span class="fl">3.5</span>, <span class="fl">5.3</span>, <span class="fl">4.4</span>, <span class="fl">1.2</span>, <span class="fl">0.7</span><span class="op">)</span>, - Z1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">18.3</span>, <span class="fl">29.6</span>, <span class="fl">46.3</span>, <span class="fl">55.1</span>, <span class="fl">65.7</span>, <span class="fl">39.1</span>, <span class="fl">36</span>, <span class="fl">15.3</span>, <span class="fl">5.6</span>, <span class="fl">1.1</span>, + Z1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">18.3</span>, <span class="fl">29.6</span>, <span class="fl">46.3</span>, <span class="fl">55.1</span>, <span class="fl">65.7</span>, <span class="fl">39.1</span>, <span class="fl">36</span>, <span class="fl">15.3</span>, <span class="fl">5.6</span>, <span class="fl">1.1</span>, <span class="fl">1.6</span>, <span class="fl">0.6</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span><span class="op">)</span>, - Z2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">2.6</span>, <span class="fl">3.8</span>, <span class="fl">15.3</span>, <span class="fl">37.2</span>, <span class="fl">31.7</span>, <span class="fl">35.6</span>, <span class="fl">14.5</span>, + Z2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">2.6</span>, <span class="fl">3.8</span>, <span class="fl">15.3</span>, <span class="fl">37.2</span>, <span class="fl">31.7</span>, <span class="fl">35.6</span>, <span class="fl">14.5</span>, <span class="fl">0.8</span>, <span class="fl">2.1</span>, <span class="fl">1.9</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span><span class="op">)</span>, - Z3 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">9.2</span>, <span class="fl">13.1</span>, <span class="fl">22.3</span>, <span class="fl">28.4</span>, <span class="fl">32.5</span>, + Z3 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">9.2</span>, <span class="fl">13.1</span>, <span class="fl">22.3</span>, <span class="fl">28.4</span>, <span class="fl">32.5</span>, <span class="fl">25.2</span>, <span class="fl">17.2</span>, <span class="fl">4.8</span>, <span class="fl">4.5</span>, <span class="fl">2.8</span>, <span class="fl">4.4</span><span class="op">)</span><span class="op">)</span> <span class="va">FOCUS_2006_Z_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_Z</span><span class="op">)</span></code></pre></div> </div> -<div id="parent-and-one-metabolite" class="section level1"> -<h1 class="hasAnchor"> -<a href="#parent-and-one-metabolite" class="anchor"></a>Parent and one metabolite</h1> +<div class="section level2"> +<h2 id="parent-and-one-metabolite">Parent and one metabolite<a class="anchor" aria-label="anchor" href="#parent-and-one-metabolite"></a> +</h2> <p>The next step is to set up the models used for the kinetic analysis. As the simultaneous fit of parent and the first metabolite is usually straightforward, Step 1 (SFO for parent only) is skipped here. We start with the model 2a, with formation and decline of metabolite Z1 and the pathway from parent directly to sink included (default in mkin).</p> <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">Z.2a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span><span class="op">)</span>, Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.2a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.2a</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.2a, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.2a, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.2a</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png" width="700"></p> <div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.Z.2a</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> -<pre><code>## Estimate se_notrans t value Pr(>t) Lower Upper -## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642 -## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600 -## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762 -## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000 -## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.2a</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> +<pre><code><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="co">## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642</span> +<span class="co">## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600</span> +<span class="co">## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762</span> +<span class="co">## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000</span> +<span class="co">## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</span></code></pre> <p>As obvious from the parameter summary (the component of the summary), the kinetic rate constant from parent compound Z to sink is very small and the t-test for this parameter suggests that it is not significantly different from zero. This suggests, in agreement with the analysis in the FOCUS kinetics report, to simplify the model by removing the pathway to sink.</p> <p>A similar result can be obtained when formation fractions are used in the model formulation:</p> <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">Z.2a.ff</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span><span class="op">)</span>, Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.2a.ff</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.2a.ff</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.2a.ff, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.2a.ff, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.2a.ff</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_2-1.png" width="700"></p> <div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.Z.2a.ff</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> -<pre><code>## Estimate se_notrans t value Pr(>t) Lower Upper -## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642 -## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600 -## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762 -## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000 -## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.2a.ff</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> +<pre><code><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="co">## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642</span> +<span class="co">## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600</span> +<span class="co">## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762</span> +<span class="co">## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000</span> +<span class="co">## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</span></code></pre> <p>Here, the ilr transformed formation fraction fitted in the model takes a very large value, and the backtransformed formation fraction from parent Z to Z1 is practically unity. Here, the covariance matrix used for the calculation of confidence intervals is not returned as the model is overparameterised.</p> <p>A simplified model is obtained by removing the pathway to the sink. </p> <p>In the following, we use the parameterisation with formation fractions in order to be able to compare with the results in the FOCUS guidance, and as it makes it easier to use parameters obtained in a previous fit when adding a further metabolite.</p> <div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">Z.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.3</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.3</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_3-1.png" width="700"></p> <div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.Z.3</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> -<pre><code>## Estimate se_notrans t value Pr(>t) Lower Upper -## Z0_0 97.01488 2.597342 37.352 2.0106e-24 91.67597 102.3538 -## k_Z0 2.23601 0.146904 15.221 9.1477e-15 1.95354 2.5593 -## k_Z1 0.48212 0.041727 11.554 4.8268e-12 0.40355 0.5760 -## sigma 4.80411 0.620208 7.746 1.6110e-08 3.52925 6.0790</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.3</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> +<pre><code><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="co">## Z0_0 97.01488 2.597342 37.352 2.0106e-24 91.67597 102.3538</span> +<span class="co">## k_Z0 2.23601 0.146904 15.221 9.1477e-15 1.95354 2.5593</span> +<span class="co">## k_Z1 0.48212 0.041727 11.554 4.8268e-12 0.40355 0.5760</span> +<span class="co">## sigma 4.80411 0.620208 7.746 1.6110e-08 3.52925 6.0790</span></code></pre> <p>As there is only one transformation product for Z0 and no pathway to sink, the formation fraction is internally fixed to unity.</p> </div> -<div id="metabolites-z2-and-z3" class="section level1"> -<h1 class="hasAnchor"> -<a href="#metabolites-z2-and-z3" class="anchor"></a>Metabolites Z2 and Z3</h1> +<div class="section level2"> +<h2 id="metabolites-z2-and-z3">Metabolites Z2 and Z3<a class="anchor" aria-label="anchor" href="#metabolites-z2-and-z3"></a> +</h2> <p>As suggested in the FOCUS report, the pathway to sink was removed for metabolite Z1 as well in the next step. While this step appears questionable on the basis of the above results, it is followed here for the purpose of comparison. Also, in the FOCUS report, it is assumed that there is additional empirical evidence that Z1 quickly and exclusively hydrolyses to Z2.</p> <div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">Z.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.5, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.5, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.5</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_5-1.png" width="700"></p> @@ -222,45 +227,45 @@ Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>, Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb30"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.FOCUS</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.FOCUS</span>, <span class="va">FOCUS_2006_Z_mkin</span>, parms.ini <span class="op">=</span> <span class="va">m.Z.5</span><span class="op">$</span><span class="va">bparms.ode</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, : -## Observations with value of zero were removed from the data</code></pre> -<pre><code>## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, : Optimisation did not converge: -## false convergence (8)</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, :</span> +<span class="co">## Observations with value of zero were removed from the data</span></code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, : Optimisation did not converge:</span> +<span class="co">## false convergence (8)</span></code></pre> <div class="sourceCode" id="cb33"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_6-1.png" width="700"></p> <div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> -<pre><code>## Estimate se_notrans t value Pr(>t) Lower Upper -## Z0_0 96.838822 1.994274 48.5584 4.0280e-42 92.826981 100.850664 -## k_Z0 2.215393 0.118458 18.7019 1.0413e-23 1.989456 2.466989 -## k_Z1 0.478305 0.028258 16.9266 6.2418e-22 0.424708 0.538666 -## k_Z2 0.451627 0.042139 10.7176 1.6314e-14 0.374339 0.544872 -## k_Z3 0.058692 0.015245 3.8499 1.7803e-04 0.034808 0.098965 -## f_Z2_to_Z3 0.471502 0.058351 8.0805 9.6608e-11 0.357769 0.588274 -## sigma 3.984431 0.383402 10.3923 4.5575e-14 3.213126 4.755736</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></code></pre></div> +<pre><code><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="co">## Z0_0 96.838822 1.994274 48.5584 4.0280e-42 92.826981 100.850664</span> +<span class="co">## k_Z0 2.215393 0.118458 18.7019 1.0413e-23 1.989456 2.466989</span> +<span class="co">## k_Z1 0.478305 0.028258 16.9266 6.2418e-22 0.424708 0.538666</span> +<span class="co">## k_Z2 0.451627 0.042139 10.7176 1.6314e-14 0.374339 0.544872</span> +<span class="co">## k_Z3 0.058692 0.015245 3.8499 1.7803e-04 0.034808 0.098965</span> +<span class="co">## f_Z2_to_Z3 0.471502 0.058351 8.0805 9.6608e-11 0.357769 0.588274</span> +<span class="co">## sigma 3.984431 0.383402 10.3923 4.5575e-14 3.213126 4.755736</span></code></pre> <div class="sourceCode" id="cb36"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span><span class="op">)</span></code></pre></div> -<pre><code>## $ff -## Z2_Z3 Z2_sink -## 0.4715 0.5285 -## -## $distimes -## DT50 DT90 -## Z0 0.31288 1.0394 -## Z1 1.44917 4.8141 -## Z2 1.53478 5.0984 -## Z3 11.80986 39.2315</code></pre> +<pre><code><span class="co">## $ff</span> +<span class="co">## Z2_Z3 Z2_sink </span> +<span class="co">## 0.4715 0.5285 </span> +<span class="co">## </span> +<span class="co">## $distimes</span> +<span class="co">## DT50 DT90</span> +<span class="co">## Z0 0.31288 1.0394</span> +<span class="co">## Z1 1.44917 4.8141</span> +<span class="co">## Z2 1.53478 5.0984</span> +<span class="co">## Z3 11.80986 39.2315</span></code></pre> <p>This fit corresponds to the final result chosen in Appendix 7 of the FOCUS report. Confidence intervals returned by mkin are based on internally transformed parameters, however.</p> </div> -<div id="using-the-sforb-model" class="section level1"> -<h1 class="hasAnchor"> -<a href="#using-the-sforb-model" class="anchor"></a>Using the SFORB model</h1> +<div class="section level2"> +<h2 id="using-the-sforb-model">Using the SFORB model<a class="anchor" aria-label="anchor" href="#using-the-sforb-model"></a> +</h2> <p>As the FOCUS report states, there is a certain tailing of the time course of metabolite Z3. Also, the time course of the parent compound is not fitted very well using the SFO model, as residues at a certain low level remain.</p> <p>Therefore, an additional model is offered here, using the single first-order reversible binding (SFORB) model for metabolite Z3. As expected, the <span class="math inline">\(\chi^2\)</span> error level is lower for metabolite Z3 using this model and the graphical fit for Z3 is improved. However, the covariance matrix is not returned.</p> <div class="sourceCode" id="cb38"><pre class="downlit sourceCode r"> @@ -268,27 +273,27 @@ Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>, Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb40"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.mkin.1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.1</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.mkin.1, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.mkin.1, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb42"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.1</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_7-1.png" width="700"></p> <div class="sourceCode" id="cb43"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/summary.html">summary</a></span><span class="op">(</span><span class="va">m.Z.mkin.1</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">cov.unscaled</span></code></pre></div> -<pre><code>## NULL</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.mkin.1</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">cov.unscaled</span></code></pre></div> +<pre><code><span class="co">## NULL</span></code></pre> <p>Therefore, a further stepwise model building is performed starting from the stage of parent and two metabolites, starting from the assumption that the model fit for the parent compound can be improved by using the SFORB model.</p> <div class="sourceCode" id="cb45"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">Z.mkin.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb47"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.mkin.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.3</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.mkin.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with -## value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.mkin.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span> +<span class="co">## value of zero were removed from the data</span></code></pre> <div class="sourceCode" id="cb49"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.3</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_9-1.png" width="700"></p> @@ -299,13 +304,14 @@ Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>, Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb52"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.mkin.4</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.4</span>, <span class="va">FOCUS_2006_Z_mkin</span>, parms.ini <span class="op">=</span> <span class="va">m.Z.mkin.3</span><span class="op">$</span><span class="va">bparms.ode</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.mkin.4, FOCUS_2006_Z_mkin, parms.ini = m.Z.mkin. -## 3$bparms.ode, : Observations with value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.mkin.4, FOCUS_2006_Z_mkin, parms.ini =</span> +<span class="co">## m.Z.mkin.3$bparms.ode, : Observations with value of zero were removed from the</span> +<span class="co">## data</span></code></pre> <div class="sourceCode" id="cb54"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.4</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_10-1.png" width="700"></p> @@ -315,25 +321,27 @@ Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>, Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb57"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.mkin.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>, parms.ini <span class="op">=</span> <span class="va">m.Z.mkin.4</span><span class="op">$</span><span class="va">bparms.ode</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini = m.Z.mkin. -## 4$bparms.ode[1:4], : Observations with value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini =</span> +<span class="co">## m.Z.mkin.4$bparms.ode[1:4], : Observations with value of zero were removed from</span> +<span class="co">## the data</span></code></pre> <div class="sourceCode" id="cb59"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.5</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_11-1.png" width="700"></p> <p>The summary view of the backtransformed parameters shows that we get no confidence intervals due to overparameterisation. As the optimized is excessively small, it seems reasonable to fix it to zero.</p> <div class="sourceCode" id="cb60"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">m.Z.mkin.5a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>, - parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="va">m.Z.mkin.5</span><span class="op">$</span><span class="va">bparms.ode</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span><span class="op">]</span>, + parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="va">m.Z.mkin.5</span><span class="op">$</span><span class="va">bparms.ode</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span><span class="op">]</span>, k_Z3_bound_free <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, fixed_parms <span class="op">=</span> <span class="st">"k_Z3_bound_free"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini = c(m.Z.mkin. -## 5$bparms.ode[1:7], : Observations with value of zero were removed from the data</code></pre> +<pre><code><span class="co">## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini =</span> +<span class="co">## c(m.Z.mkin.5$bparms.ode[1:7], : Observations with value of zero were removed</span> +<span class="co">## from the data</span></code></pre> <div class="sourceCode" id="cb62"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.5a</span><span class="op">)</span></code></pre></div> <p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_11a-1.png" width="700"></p> @@ -345,29 +353,29 @@ <p>The endpoints obtained with this model are</p> <div class="sourceCode" id="cb64"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="fu"><a href="../../reference/endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m.Z.mkin.5a</span><span class="op">)</span></code></pre></div> -<pre><code>## $ff -## Z0_free Z2_Z3 Z2_sink Z3_free -## 1.00000 0.53656 0.46344 1.00000 -## -## $SFORB -## Z0_b1 Z0_b2 Z3_b1 Z3_b2 -## 2.4471322 0.0075125 0.0800069 0.0000000 -## -## $distimes -## DT50 DT90 DT50back DT50_Z0_b1 DT50_Z0_b2 DT50_Z3_b1 DT50_Z3_b2 -## Z0 0.3043 1.1848 0.35666 0.28325 92.266 NA NA -## Z1 1.5148 5.0320 NA NA NA NA NA -## Z2 1.6414 5.4526 NA NA NA NA NA -## Z3 NA NA NA NA NA 8.6636 Inf</code></pre> +<pre><code><span class="co">## $ff</span> +<span class="co">## Z0_free Z2_Z3 Z2_sink Z3_free </span> +<span class="co">## 1.00000 0.53656 0.46344 1.00000 </span> +<span class="co">## </span> +<span class="co">## $SFORB</span> +<span class="co">## Z0_b1 Z0_b2 Z3_b1 Z3_b2 </span> +<span class="co">## 2.4471322 0.0075125 0.0800069 0.0000000 </span> +<span class="co">## </span> +<span class="co">## $distimes</span> +<span class="co">## DT50 DT90 DT50back DT50_Z0_b1 DT50_Z0_b2 DT50_Z3_b1 DT50_Z3_b2</span> +<span class="co">## Z0 0.3043 1.1848 0.35666 0.28325 92.266 NA NA</span> +<span class="co">## Z1 1.5148 5.0320 NA NA NA NA NA</span> +<span class="co">## Z2 1.6414 5.4526 NA NA NA NA NA</span> +<span class="co">## Z3 NA NA NA NA NA 8.6636 Inf</span></code></pre> <p>It is clear the degradation rate of Z3 towards the end of the experiment is very low as DT50_Z3_b2 (the second Eigenvalue of the system of two differential equations representing the SFORB system for Z3, corresponding to the slower rate constant of the DFOP model) is reported to be infinity. However, this appears to be a feature of the data.</p> </div> -<div id="references" class="section level1"> -<h1 class="hasAnchor"> -<a href="#references" class="anchor"></a>References</h1> +<div class="section level2"> +<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> <!-- vim: set foldmethod=syntax: --> <div id="refs" class="references hanging-indent"> <div id="ref-FOCUSkinetics2014"> -<p>FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> +<p>FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in Eu Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>.</p> </div> </div> </div> @@ -384,11 +392,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -397,5 +407,7 @@ + + </body> </html> diff --git a/docs/articles/web_only/FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png b/docs/articles/web_only/FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png Binary files differindex 2e70b207..be652d31 100644 --- a/docs/articles/web_only/FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png +++ b/docs/articles/web_only/FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png diff --git 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b/docs/articles/web_only/NAFTA_examples.html index 65a71b56..996e5d49 100644 --- a/docs/articles/web_only/NAFTA_examples.html +++ b/docs/articles/web_only/NAFTA_examples.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,908 +99,908 @@ - </header><script src="NAFTA_examples_files/header-attrs-2.7/header-attrs.js"></script><script src="NAFTA_examples_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="NAFTA_examples_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Evaluation of example datasets from Attachment 1 to the US EPA SOP for the NAFTA guidance</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">26 February 2019 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">26 February 2019 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/web_only/NAFTA_examples.rmd"><code>vignettes/web_only/NAFTA_examples.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/NAFTA_examples.rmd" class="external-link"><code>vignettes/web_only/NAFTA_examples.rmd</code></a></small> <div class="hidden name"><code>NAFTA_examples.rmd</code></div> </div> -<div id="introduction" class="section level1"> -<h1 class="hasAnchor"> -<a href="#introduction" class="anchor"></a>Introduction</h1> +<div class="section level2"> +<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> +</h2> <p>In this document, the example evaluations provided in Attachment 1 to the SOP of US EPA for using the NAFTA guidance <span class="citation">(US EPA 2015)</span> are repeated using mkin. The original evaluations reported in the attachment were performed using PestDF in version 0.8.4. Note that PestDF 0.8.13 is the version distributed at the US EPA website today (2019-02-26).</p> <p>The datasets are now distributed with the mkin package.</p> </div> -<div id="examples-where-dfop-did-not-converge-with-pestdf-0-8-4" class="section level1"> -<h1 class="hasAnchor"> -<a href="#examples-where-dfop-did-not-converge-with-pestdf-0-8-4" class="anchor"></a>Examples where DFOP did not converge with PestDF 0.8.4</h1> +<div class="section level2"> +<h2 id="examples-where-dfop-did-not-converge-with-pestdf-0-8-4">Examples where DFOP did not converge with PestDF 0.8.4<a class="anchor" aria-label="anchor" href="#examples-where-dfop-did-not-converge-with-pestdf-0-8-4"></a> +</h2> <p>In attachment 1, it is reported that the DFOP model does not converge for these datasets when PestDF 0.8.4 was used. For all four datasets, the DFOP model can be fitted with mkin (see below). The negative half-life given by PestDF 0.8.4 for these fits appears to be the result of a bug. The results for the other two models (SFO and IORE) are the same.</p> -<div id="example-on-page-5-upper-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-5-upper-panel" class="anchor"></a>Example on page 5, upper panel</h2> +<div class="section level3"> +<h3 id="example-on-page-5-upper-panel">Example on page 5, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-5-upper-panel"></a> +</h3> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p5a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p5a-1.png" width="700"></p> <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 465.21753 56.27506 32.06401 -## -## Critical sum of squares for checking the SFO model: -## [1] 64.4304 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 95.8401 4.67e-21 92.245 99.4357 -## k_parent 0.0102 3.92e-12 0.009 0.0117 -## sigma 4.8230 3.81e-06 3.214 6.4318 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 1.01e+02 NA 9.91e+01 1.02e+02 -## k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05 -## N_parent 2.57e+00 NA 2.25e+00 2.89e+00 -## sigma 1.68e+00 NA 1.12e+00 2.24e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 9.99e+01 1.41e-26 98.8116 101.0810 -## k1 2.67e-02 5.05e-06 0.0243 0.0295 -## k2 2.26e-12 5.00e-01 0.0000 Inf -## g 6.47e-01 3.67e-06 0.6248 0.6677 -## sigma 1.27e+00 8.91e-06 0.8395 1.6929 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 67.7 2.25e+02 6.77e+01 -## IORE 58.2 1.07e+03 3.22e+02 -## DFOP 55.5 5.59e+11 3.07e+11 -## -## Representative half-life: -## [1] 321.51</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 465.21753 56.27506 32.06401 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 64.4304</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 95.8401 4.67e-21 92.245 99.4357</span> +<span class="co">## k_parent 0.0102 3.92e-12 0.009 0.0117</span> +<span class="co">## sigma 4.8230 3.81e-06 3.214 6.4318</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.01e+02 NA 9.91e+01 1.02e+02</span> +<span class="co">## k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05</span> +<span class="co">## N_parent 2.57e+00 NA 2.25e+00 2.89e+00</span> +<span class="co">## sigma 1.68e+00 NA 1.12e+00 2.24e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.99e+01 1.41e-26 98.8116 101.0810</span> +<span class="co">## k1 2.67e-02 5.05e-06 0.0243 0.0295</span> +<span class="co">## k2 2.26e-12 5.00e-01 0.0000 Inf</span> +<span class="co">## g 6.47e-01 3.67e-06 0.6248 0.6677</span> +<span class="co">## sigma 1.27e+00 8.91e-06 0.8395 1.6929</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 67.7 2.25e+02 6.77e+01</span> +<span class="co">## IORE 58.2 1.07e+03 3.22e+02</span> +<span class="co">## DFOP 55.5 5.59e+11 3.07e+11</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 321.51</span></code></pre> </div> -<div id="example-on-page-5-lower-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-5-lower-panel" class="anchor"></a>Example on page 5, lower panel</h2> +<div class="section level3"> +<h3 id="example-on-page-5-lower-panel">Example on page 5, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-5-lower-panel"></a> +</h3> <div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p5b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p5b-1.png" width="700"></p> <div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 94.81123 10.10936 7.55871 -## -## Critical sum of squares for checking the SFO model: -## [1] 11.77879 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 96.497 2.32e-24 94.85271 98.14155 -## k_parent 0.008 3.42e-14 0.00737 0.00869 -## sigma 2.295 1.22e-05 1.47976 3.11036 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 9.85e+01 1.17e-28 9.79e+01 9.92e+01 -## k__iore_parent 1.53e-04 6.50e-03 7.21e-05 3.26e-04 -## N_parent 1.94e+00 5.88e-13 1.76e+00 2.12e+00 -## sigma 7.49e-01 1.63e-05 4.82e-01 1.02e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 9.84e+01 1.24e-27 97.8078 98.9187 -## k1 1.55e-02 4.10e-04 0.0143 0.0167 -## k2 8.63e-12 5.00e-01 0.0000 Inf -## g 6.89e-01 2.92e-03 0.6626 0.7142 -## sigma 6.48e-01 2.38e-05 0.4147 0.8813 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 86.6 2.88e+02 8.66e+01 -## IORE 85.5 7.17e+02 2.16e+02 -## DFOP 83.6 1.32e+11 8.04e+10 -## -## Representative half-life: -## [1] 215.87</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 94.81123 10.10936 7.55871 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 11.77879</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.497 2.32e-24 94.85271 98.14155</span> +<span class="co">## k_parent 0.008 3.42e-14 0.00737 0.00869</span> +<span class="co">## sigma 2.295 1.22e-05 1.47976 3.11036</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.85e+01 1.17e-28 9.79e+01 9.92e+01</span> +<span class="co">## k__iore_parent 1.53e-04 6.50e-03 7.21e-05 3.26e-04</span> +<span class="co">## N_parent 1.94e+00 5.88e-13 1.76e+00 2.12e+00</span> +<span class="co">## sigma 7.49e-01 1.63e-05 4.82e-01 1.02e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.84e+01 1.24e-27 97.8078 98.9187</span> +<span class="co">## k1 1.55e-02 4.10e-04 0.0143 0.0167</span> +<span class="co">## k2 8.63e-12 5.00e-01 0.0000 Inf</span> +<span class="co">## g 6.89e-01 2.92e-03 0.6626 0.7142</span> +<span class="co">## sigma 6.48e-01 2.38e-05 0.4147 0.8813</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 86.6 2.88e+02 8.66e+01</span> +<span class="co">## IORE 85.5 7.17e+02 2.16e+02</span> +<span class="co">## DFOP 83.6 1.32e+11 8.04e+10</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 215.87</span></code></pre> </div> -<div id="example-on-page-6" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-6" class="anchor"></a>Example on page 6</h2> +<div class="section level3"> +<h3 id="example-on-page-6">Example on page 6<a class="anchor" aria-label="anchor" href="#example-on-page-6"></a> +</h3> <div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p6</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p6"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p6-1.png" width="700"></p> <div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 188.45361 51.00699 42.46931 -## -## Critical sum of squares for checking the SFO model: -## [1] 58.39888 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 94.7759 7.29e-24 92.3478 97.2039 -## k_parent 0.0179 8.02e-16 0.0166 0.0194 -## sigma 3.0696 3.81e-06 2.0456 4.0936 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 97.12446 2.63e-26 95.62461 98.62431 -## k__iore_parent 0.00252 1.95e-03 0.00134 0.00472 -## N_parent 1.49587 4.07e-13 1.33896 1.65279 -## sigma 1.59698 5.05e-06 1.06169 2.13227 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 9.66e+01 1.57e-25 95.3476 97.8979 -## k1 2.55e-02 7.33e-06 0.0233 0.0278 -## k2 3.22e-11 5.00e-01 0.0000 Inf -## g 8.61e-01 7.55e-06 0.8314 0.8867 -## sigma 1.46e+00 6.93e-06 0.9661 1.9483 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 38.6 1.28e+02 3.86e+01 -## IORE 34.0 1.77e+02 5.32e+01 -## DFOP 34.1 1.01e+10 2.15e+10 -## -## Representative half-life: -## [1] 53.17</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 188.45361 51.00699 42.46931 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 58.39888</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 94.7759 7.29e-24 92.3478 97.2039</span> +<span class="co">## k_parent 0.0179 8.02e-16 0.0166 0.0194</span> +<span class="co">## sigma 3.0696 3.81e-06 2.0456 4.0936</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.12446 2.63e-26 95.62461 98.62431</span> +<span class="co">## k__iore_parent 0.00252 1.95e-03 0.00134 0.00472</span> +<span class="co">## N_parent 1.49587 4.07e-13 1.33896 1.65279</span> +<span class="co">## sigma 1.59698 5.05e-06 1.06169 2.13227</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.66e+01 1.57e-25 95.3476 97.8979</span> +<span class="co">## k1 2.55e-02 7.33e-06 0.0233 0.0278</span> +<span class="co">## k2 3.22e-11 5.00e-01 0.0000 Inf</span> +<span class="co">## g 8.61e-01 7.55e-06 0.8314 0.8867</span> +<span class="co">## sigma 1.46e+00 6.93e-06 0.9661 1.9483</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 38.6 1.28e+02 3.86e+01</span> +<span class="co">## IORE 34.0 1.77e+02 5.32e+01</span> +<span class="co">## DFOP 34.1 1.01e+10 2.15e+10</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 53.17</span></code></pre> </div> -<div id="example-on-page-7" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-7" class="anchor"></a>Example on page 7</h2> +<div class="section level3"> +<h3 id="example-on-page-7">Example on page 7<a class="anchor" aria-label="anchor" href="#example-on-page-7"></a> +</h3> <div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p7</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p7"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p7-1.png" width="700"></p> <div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 3661.661 3195.030 3174.145 -## -## Critical sum of squares for checking the SFO model: -## [1] 3334.194 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 96.41796 4.80e-53 93.32245 99.51347 -## k_parent 0.00735 7.64e-21 0.00641 0.00843 -## sigma 7.94557 1.83e-15 6.46713 9.42401 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 9.92e+01 NA 9.55e+01 1.03e+02 -## k__iore_parent 1.60e-05 NA 1.45e-07 1.77e-03 -## N_parent 2.45e+00 NA 1.35e+00 3.54e+00 -## sigma 7.42e+00 NA 6.04e+00 8.80e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 9.89e+01 9.44e-49 95.4640 102.2573 -## k1 1.81e-02 1.75e-01 0.0116 0.0281 -## k2 3.63e-10 5.00e-01 0.0000 Inf -## g 6.06e-01 2.19e-01 0.4826 0.7178 -## sigma 7.40e+00 2.97e-15 6.0201 8.7754 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 94.3 3.13e+02 9.43e+01 -## IORE 96.7 1.51e+03 4.55e+02 -## DFOP 96.4 3.77e+09 1.91e+09 -## -## Representative half-life: -## [1] 454.55</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 3661.661 3195.030 3174.145 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 3334.194</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.41796 4.80e-53 93.32245 99.51347</span> +<span class="co">## k_parent 0.00735 7.64e-21 0.00641 0.00843</span> +<span class="co">## sigma 7.94557 1.83e-15 6.46713 9.42401</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.92e+01 NA 9.55e+01 1.03e+02</span> +<span class="co">## k__iore_parent 1.60e-05 NA 1.45e-07 1.77e-03</span> +<span class="co">## N_parent 2.45e+00 NA 1.35e+00 3.54e+00</span> +<span class="co">## sigma 7.42e+00 NA 6.04e+00 8.80e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.89e+01 9.44e-49 95.4640 102.2573</span> +<span class="co">## k1 1.81e-02 1.75e-01 0.0116 0.0281</span> +<span class="co">## k2 3.63e-10 5.00e-01 0.0000 Inf</span> +<span class="co">## g 6.06e-01 2.19e-01 0.4826 0.7178</span> +<span class="co">## sigma 7.40e+00 2.97e-15 6.0201 8.7754</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 94.3 3.13e+02 9.43e+01</span> +<span class="co">## IORE 96.7 1.51e+03 4.55e+02</span> +<span class="co">## DFOP 96.4 3.77e+09 1.91e+09</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 454.55</span></code></pre> </div> </div> -<div id="examples-where-the-representative-half-life-deviates-from-the-observed-dt50" class="section level1"> -<h1 class="hasAnchor"> -<a href="#examples-where-the-representative-half-life-deviates-from-the-observed-dt50" class="anchor"></a>Examples where the representative half-life deviates from the observed DT50</h1> -<div id="example-on-page-8" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-8" class="anchor"></a>Example on page 8</h2> +<div class="section level2"> +<h2 id="examples-where-the-representative-half-life-deviates-from-the-observed-dt50">Examples where the representative half-life deviates from the observed DT50<a class="anchor" aria-label="anchor" href="#examples-where-the-representative-half-life-deviates-from-the-observed-dt50"></a> +</h2> +<div class="section level3"> +<h3 id="example-on-page-8">Example on page 8<a class="anchor" aria-label="anchor" href="#example-on-page-8"></a> +</h3> <p>For this dataset, the IORE fit does not converge when the default starting values used by mkin for the IORE model are used. Therefore, a lower value for the rate constant is used here.</p> <div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">p8</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p8"</span><span class="op">]</span><span class="op">]</span>, parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span>k__iore_parent <span class="op">=</span> <span class="fl">1e-3</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<code class="sourceCode R"><span class="va">p8</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p8"</span><span class="op">]</span><span class="op">]</span>, parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k__iore_parent <span class="op">=</span> <span class="fl">1e-3</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p8-1.png" width="700"></p> <div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 1996.9408 444.9237 547.5616 -## -## Critical sum of squares for checking the SFO model: -## [1] 477.4924 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 88.16549 6.53e-29 83.37344 92.95754 -## k_parent 0.00803 1.67e-13 0.00674 0.00957 -## sigma 7.44786 4.17e-10 5.66209 9.23363 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 9.77e+01 7.03e-35 9.44e+01 1.01e+02 -## k__iore_parent 6.14e-05 3.20e-02 2.12e-05 1.78e-04 -## N_parent 2.27e+00 4.23e-18 2.00e+00 2.54e+00 -## sigma 3.52e+00 5.36e-10 2.67e+00 4.36e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 95.70619 8.99e-32 91.87941 99.53298 -## k1 0.02500 5.25e-04 0.01422 0.04394 -## k2 0.00273 6.84e-03 0.00125 0.00597 -## g 0.58835 2.84e-06 0.36595 0.77970 -## sigma 3.90001 6.94e-10 2.96260 4.83741 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 86.3 287 86.3 -## IORE 53.4 668 201.0 -## DFOP 55.6 517 253.0 -## -## Representative half-life: -## [1] 201.03</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 1996.9408 444.9237 547.5616 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 477.4924</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 88.16549 6.53e-29 83.37344 92.95754</span> +<span class="co">## k_parent 0.00803 1.67e-13 0.00674 0.00957</span> +<span class="co">## sigma 7.44786 4.17e-10 5.66209 9.23363</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.77e+01 7.03e-35 9.44e+01 1.01e+02</span> +<span class="co">## k__iore_parent 6.14e-05 3.20e-02 2.12e-05 1.78e-04</span> +<span class="co">## N_parent 2.27e+00 4.23e-18 2.00e+00 2.54e+00</span> +<span class="co">## sigma 3.52e+00 5.36e-10 2.67e+00 4.36e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 95.70619 8.99e-32 91.87941 99.53298</span> +<span class="co">## k1 0.02500 5.25e-04 0.01422 0.04394</span> +<span class="co">## k2 0.00273 6.84e-03 0.00125 0.00597</span> +<span class="co">## g 0.58835 2.84e-06 0.36595 0.77970</span> +<span class="co">## sigma 3.90001 6.94e-10 2.96260 4.83741</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 86.3 287 86.3</span> +<span class="co">## IORE 53.4 668 201.0</span> +<span class="co">## DFOP 55.6 517 253.0</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 201.03</span></code></pre> </div> </div> -<div id="examples-where-sfo-was-not-selected-for-an-abiotic-study" class="section level1"> -<h1 class="hasAnchor"> -<a href="#examples-where-sfo-was-not-selected-for-an-abiotic-study" class="anchor"></a>Examples where SFO was not selected for an abiotic study</h1> -<div id="example-on-page-9-upper-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-9-upper-panel" class="anchor"></a>Example on page 9, upper panel</h2> +<div class="section level2"> +<h2 id="examples-where-sfo-was-not-selected-for-an-abiotic-study">Examples where SFO was not selected for an abiotic study<a class="anchor" aria-label="anchor" href="#examples-where-sfo-was-not-selected-for-an-abiotic-study"></a> +</h2> +<div class="section level3"> +<h3 id="example-on-page-9-upper-panel">Example on page 9, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-9-upper-panel"></a> +</h3> <div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p9a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p9a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p9a-1.png" width="700"></p> <div class="sourceCode" id="cb35"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 839.35238 88.57064 9.93363 -## -## Critical sum of squares for checking the SFO model: -## [1] 105.5678 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 88.1933 3.06e-12 79.9447 96.4419 -## k_parent 0.0409 2.07e-07 0.0324 0.0516 -## sigma 7.2429 3.92e-05 4.4768 10.0090 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 9.89e+01 1.12e-16 9.54e+01 1.02e+02 -## k__iore_parent 1.93e-05 1.13e-01 3.49e-06 1.06e-04 -## N_parent 2.91e+00 1.45e-09 2.50e+00 3.32e+00 -## sigma 2.35e+00 5.31e-05 1.45e+00 3.26e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 9.85e+01 2.54e-20 97.390 99.672 -## k1 1.38e-01 3.52e-05 0.131 0.146 -## k2 9.02e-13 5.00e-01 0.000 Inf -## g 6.52e-01 8.13e-06 0.642 0.661 -## sigma 7.88e-01 6.13e-02 0.481 1.095 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 16.9 5.63e+01 1.69e+01 -## IORE 11.6 3.37e+02 1.01e+02 -## DFOP 10.5 1.38e+12 7.69e+11 -## -## Representative half-life: -## [1] 101.43</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 839.35238 88.57064 9.93363 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 105.5678</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 88.1933 3.06e-12 79.9447 96.4419</span> +<span class="co">## k_parent 0.0409 2.07e-07 0.0324 0.0516</span> +<span class="co">## sigma 7.2429 3.92e-05 4.4768 10.0090</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.89e+01 1.12e-16 9.54e+01 1.02e+02</span> +<span class="co">## k__iore_parent 1.93e-05 1.13e-01 3.49e-06 1.06e-04</span> +<span class="co">## N_parent 2.91e+00 1.45e-09 2.50e+00 3.32e+00</span> +<span class="co">## sigma 2.35e+00 5.31e-05 1.45e+00 3.26e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 9.85e+01 2.54e-20 97.390 99.672</span> +<span class="co">## k1 1.38e-01 3.52e-05 0.131 0.146</span> +<span class="co">## k2 9.02e-13 5.00e-01 0.000 Inf</span> +<span class="co">## g 6.52e-01 8.13e-06 0.642 0.661</span> +<span class="co">## sigma 7.88e-01 6.13e-02 0.481 1.095</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 16.9 5.63e+01 1.69e+01</span> +<span class="co">## IORE 11.6 3.37e+02 1.01e+02</span> +<span class="co">## DFOP 10.5 1.38e+12 7.69e+11</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 101.43</span></code></pre> <p>In this example, the residuals of the SFO indicate a lack of fit of this model, so even if it was an abiotic experiment, the data do not suggest a simple exponential decline.</p> </div> -<div id="example-on-page-9-lower-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-9-lower-panel" class="anchor"></a>Example on page 9, lower panel</h2> +<div class="section level3"> +<h3 id="example-on-page-9-lower-panel">Example on page 9, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-9-lower-panel"></a> +</h3> <div class="sourceCode" id="cb37"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p9b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p9b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(diag(covar_notrans)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb44"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p9b-1.png" width="700"></p> <div class="sourceCode" id="cb45"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 35.64867 23.22334 35.64867 -## -## Critical sum of squares for checking the SFO model: -## [1] 28.54188 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 94.7123 2.15e-19 93.178 96.2464 -## k_parent 0.0389 4.47e-14 0.037 0.0408 -## sigma 1.5957 1.28e-04 0.932 2.2595 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 93.863 2.32e-18 92.4565 95.269 -## k__iore_parent 0.127 1.85e-02 0.0504 0.321 -## N_parent 0.711 1.88e-05 0.4843 0.937 -## sigma 1.288 1.76e-04 0.7456 1.830 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 94.7123 1.61e-16 93.1355 96.2891 -## k1 0.0389 1.08e-04 0.0266 0.0569 -## k2 0.0389 2.23e-04 0.0255 0.0592 -## g 0.5256 NaN NA NA -## sigma 1.5957 2.50e-04 0.9135 2.2779 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 17.8 59.2 17.8 -## IORE 18.4 49.2 14.8 -## DFOP 17.8 59.2 17.8 -## -## Representative half-life: -## [1] 14.8</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 35.64867 23.22334 35.64867 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 28.54188</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 94.7123 2.15e-19 93.178 96.2464</span> +<span class="co">## k_parent 0.0389 4.47e-14 0.037 0.0408</span> +<span class="co">## sigma 1.5957 1.28e-04 0.932 2.2595</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 93.863 2.32e-18 92.4565 95.269</span> +<span class="co">## k__iore_parent 0.127 1.85e-02 0.0504 0.321</span> +<span class="co">## N_parent 0.711 1.88e-05 0.4843 0.937</span> +<span class="co">## sigma 1.288 1.76e-04 0.7456 1.830</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 94.7123 1.61e-16 93.1355 96.2891</span> +<span class="co">## k1 0.0389 1.08e-04 0.0266 0.0569</span> +<span class="co">## k2 0.0389 2.23e-04 0.0255 0.0592</span> +<span class="co">## g 0.5256 NaN NA NA</span> +<span class="co">## sigma 1.5957 2.50e-04 0.9135 2.2779</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 17.8 59.2 17.8</span> +<span class="co">## IORE 18.4 49.2 14.8</span> +<span class="co">## DFOP 17.8 59.2 17.8</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 14.8</span></code></pre> <p>Here, mkin gives a longer slow DT50 for the DFOP model (17.8 days) than PestDF (13.5 days). Presumably, this is related to the fact that PestDF gives a negative value for the proportion of the fast degradation which should be between 0 and 1, inclusive. This parameter is called f in PestDF and g in mkin. In mkin, it is restricted to the interval from 0 to 1.</p> </div> -<div id="example-on-page-10" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-10" class="anchor"></a>Example on page 10</h2> +<div class="section level3"> +<h3 id="example-on-page-10">Example on page 10<a class="anchor" aria-label="anchor" href="#example-on-page-10"></a> +</h3> <div class="sourceCode" id="cb47"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p10</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p10"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb53"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p10-1.png" width="700"></p> <div class="sourceCode" id="cb54"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 899.4089 336.4348 899.4089 -## -## Critical sum of squares for checking the SFO model: -## [1] 413.4841 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 101.7315 6.42e-11 91.9259 111.5371 -## k_parent 0.0495 1.70e-07 0.0404 0.0607 -## sigma 8.0152 1.28e-04 4.6813 11.3491 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 96.86 3.32e-12 90.848 102.863 -## k__iore_parent 2.96 7.91e-02 0.687 12.761 -## N_parent 0.00 5.00e-01 -0.372 0.372 -## sigma 4.90 1.77e-04 2.837 6.968 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 101.7315 1.41e-09 91.6534 111.8097 -## k1 0.0495 6.58e-03 0.0303 0.0809 -## k2 0.0495 2.60e-03 0.0410 0.0598 -## g 0.4487 5.00e-01 NA NA -## sigma 8.0152 2.50e-04 4.5886 11.4418 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 14.0 46.5 14.00 -## IORE 16.4 29.4 8.86 -## DFOP 14.0 46.5 14.00 -## -## Representative half-life: -## [1] 8.86</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 899.4089 336.4348 899.4089 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 413.4841</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 101.7315 6.42e-11 91.9259 111.5371</span> +<span class="co">## k_parent 0.0495 1.70e-07 0.0404 0.0607</span> +<span class="co">## sigma 8.0152 1.28e-04 4.6813 11.3491</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.86 3.32e-12 90.848 102.863</span> +<span class="co">## k__iore_parent 2.96 7.91e-02 0.687 12.761</span> +<span class="co">## N_parent 0.00 5.00e-01 -0.372 0.372</span> +<span class="co">## sigma 4.90 1.77e-04 2.837 6.968</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 101.7315 1.41e-09 91.6534 111.8097</span> +<span class="co">## k1 0.0495 6.58e-03 0.0303 0.0809</span> +<span class="co">## k2 0.0495 2.60e-03 0.0410 0.0598</span> +<span class="co">## g 0.4487 5.00e-01 NA NA</span> +<span class="co">## sigma 8.0152 2.50e-04 4.5886 11.4418</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 14.0 46.5 14.00</span> +<span class="co">## IORE 16.4 29.4 8.86</span> +<span class="co">## DFOP 14.0 46.5 14.00</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 8.86</span></code></pre> <p>Here, a value below N is given for the IORE model, because the data suggests a faster decline towards the end of the experiment, which appears physically rather unlikely in the case of a photolysis study. It seems PestDF does not constrain N to values above zero, thus the slight difference in IORE model parameters between PestDF and mkin.</p> </div> </div> -<div id="the-dt50-was-not-observed-during-the-study" class="section level1"> -<h1 class="hasAnchor"> -<a href="#the-dt50-was-not-observed-during-the-study" class="anchor"></a>The DT50 was not observed during the study</h1> -<div id="example-on-page-11" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-11" class="anchor"></a>Example on page 11</h2> +<div class="section level2"> +<h2 id="the-dt50-was-not-observed-during-the-study">The DT50 was not observed during the study<a class="anchor" aria-label="anchor" href="#the-dt50-was-not-observed-during-the-study"></a> +</h2> +<div class="section level3"> +<h3 id="example-on-page-11">Example on page 11<a class="anchor" aria-label="anchor" href="#example-on-page-11"></a> +</h3> <div class="sourceCode" id="cb56"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p11</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p11"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb59"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p11-1.png" width="700"></p> <div class="sourceCode" id="cb60"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 579.6805 204.7932 144.7783 -## -## Critical sum of squares for checking the SFO model: -## [1] 251.6944 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 96.15820 4.83e-13 90.24934 1.02e+02 -## k_parent 0.00321 4.71e-05 0.00222 4.64e-03 -## sigma 6.43473 1.28e-04 3.75822 9.11e+00 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 1.05e+02 NA 9.90e+01 1.10e+02 -## k__iore_parent 3.11e-17 NA 1.35e-20 7.18e-14 -## N_parent 8.36e+00 NA 6.62e+00 1.01e+01 -## sigma 3.82e+00 NA 2.21e+00 5.44e+00 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 1.05e+02 9.47e-13 99.9990 109.1224 -## k1 4.41e-02 5.95e-03 0.0296 0.0658 -## k2 9.94e-13 5.00e-01 0.0000 Inf -## g 3.22e-01 1.45e-03 0.2814 0.3650 -## sigma 3.22e+00 3.52e-04 1.8410 4.5906 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 2.16e+02 7.18e+02 2.16e+02 -## IORE 9.73e+02 1.37e+08 4.11e+07 -## DFOP 3.07e+11 1.93e+12 6.98e+11 -## -## Representative half-life: -## [1] 41148170</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 579.6805 204.7932 144.7783 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 251.6944</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.15820 4.83e-13 90.24934 1.02e+02</span> +<span class="co">## k_parent 0.00321 4.71e-05 0.00222 4.64e-03</span> +<span class="co">## sigma 6.43473 1.28e-04 3.75822 9.11e+00</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.05e+02 NA 9.90e+01 1.10e+02</span> +<span class="co">## k__iore_parent 3.11e-17 NA 1.35e-20 7.18e-14</span> +<span class="co">## N_parent 8.36e+00 NA 6.62e+00 1.01e+01</span> +<span class="co">## sigma 3.82e+00 NA 2.21e+00 5.44e+00</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.05e+02 9.47e-13 99.9990 109.1224</span> +<span class="co">## k1 4.41e-02 5.95e-03 0.0296 0.0658</span> +<span class="co">## k2 9.94e-13 5.00e-01 0.0000 Inf</span> +<span class="co">## g 3.22e-01 1.45e-03 0.2814 0.3650</span> +<span class="co">## sigma 3.22e+00 3.52e-04 1.8410 4.5906</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 2.16e+02 7.18e+02 2.16e+02</span> +<span class="co">## IORE 9.73e+02 1.37e+08 4.11e+07</span> +<span class="co">## DFOP 3.07e+11 1.93e+12 6.98e+11</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 41148170</span></code></pre> <p>In this case, the DFOP fit reported for PestDF resulted in a negative value for the slower rate constant, which is not possible in mkin. The other results are in agreement.</p> </div> </div> -<div id="n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant" class="section level1"> -<h1 class="hasAnchor"> -<a href="#n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant" class="anchor"></a>N is less than 1 and the DFOP rate constants are like the SFO rate constant</h1> +<div class="section level2"> +<h2 id="n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant">N is less than 1 and the DFOP rate constants are like the SFO rate constant<a class="anchor" aria-label="anchor" href="#n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant"></a> +</h2> <p>In the following three examples, the same results are obtained with mkin as reported for PestDF. As in the case on page 10, the N values below 1 are deemed unrealistic and appear to be the result of an overparameterisation.</p> -<div id="example-on-page-12-upper-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-12-upper-panel" class="anchor"></a>Example on page 12, upper panel</h2> +<div class="section level3"> +<h3 id="example-on-page-12-upper-panel">Example on page 12, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-12-upper-panel"></a> +</h3> <div class="sourceCode" id="cb62"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p12a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p12a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in summary.mkinfit(x): Could not calculate correlation; no covariance -## matrix</code></pre> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(diag(covar_notrans)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in summary.mkinfit(x): Could not calculate correlation; no covariance</span> +<span class="co">## matrix</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb70"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p12a-1.png" width="700"></p> <div class="sourceCode" id="cb71"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 695.4440 220.0685 695.4440 -## -## Critical sum of squares for checking the SFO model: -## [1] 270.4679 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 100.521 8.75e-12 92.461 108.581 -## k_parent 0.124 3.61e-08 0.104 0.148 -## sigma 7.048 1.28e-04 4.116 9.980 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 96.823 NA NA NA -## k__iore_parent 2.436 NA NA NA -## N_parent 0.263 NA NA NA -## sigma 3.965 NA NA NA -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 100.521 2.74e-10 92.2366 108.805 -## k1 0.124 2.53e-05 0.0908 0.170 -## k2 0.124 2.52e-02 0.0456 0.339 -## g 0.793 NaN NA NA -## sigma 7.048 2.50e-04 4.0349 10.061 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 5.58 18.5 5.58 -## IORE 6.49 13.2 3.99 -## DFOP 5.58 18.5 5.58 -## -## Representative half-life: -## [1] 3.99</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 695.4440 220.0685 695.4440 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 270.4679</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 100.521 8.75e-12 92.461 108.581</span> +<span class="co">## k_parent 0.124 3.61e-08 0.104 0.148</span> +<span class="co">## sigma 7.048 1.28e-04 4.116 9.980</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 96.823 NA NA NA</span> +<span class="co">## k__iore_parent 2.436 NA NA NA</span> +<span class="co">## N_parent 0.263 NA NA NA</span> +<span class="co">## sigma 3.965 NA NA NA</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 100.521 2.74e-10 92.2366 108.805</span> +<span class="co">## k1 0.124 2.53e-05 0.0908 0.170</span> +<span class="co">## k2 0.124 2.52e-02 0.0456 0.339</span> +<span class="co">## g 0.793 NaN NA NA</span> +<span class="co">## sigma 7.048 2.50e-04 4.0349 10.061</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 5.58 18.5 5.58</span> +<span class="co">## IORE 6.49 13.2 3.99</span> +<span class="co">## DFOP 5.58 18.5 5.58</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 3.99</span></code></pre> </div> -<div id="example-on-page-12-lower-panel" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-12-lower-panel" class="anchor"></a>Example on page 12, lower panel</h2> +<div class="section level3"> +<h3 id="example-on-page-12-lower-panel">Example on page 12, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-12-lower-panel"></a> +</h3> <div class="sourceCode" id="cb73"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p12b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p12b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in qt(alpha/2, rdf): NaNs produced</code></pre> -<pre><code>## Warning in qt(1 - alpha/2, rdf): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(diag(covar_notrans)): NaNs produced</code></pre> -<pre><code>## Warning in pt(abs(tval), rdf, lower.tail = FALSE): NaNs produced</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in qt(alpha/2, rdf): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in qt(1 - alpha/2, rdf): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in pt(abs(tval), rdf, lower.tail = FALSE): NaNs produced</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb80"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p12b-1.png" width="700"></p> <div class="sourceCode" id="cb81"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 58.90242 19.06353 58.90242 -## -## Critical sum of squares for checking the SFO model: -## [1] 51.51756 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 97.6840 0.00039 85.9388 109.4292 -## k_parent 0.0589 0.00261 0.0431 0.0805 -## sigma 3.4323 0.04356 -1.2377 8.1023 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 95.523 0.0055 74.539157 116.51 -## k__iore_parent 0.333 0.1433 0.000717 154.57 -## N_parent 0.568 0.0677 -0.989464 2.13 -## sigma 1.953 0.0975 -5.893100 9.80 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 97.6840 NaN NaN NaN -## k1 0.0589 NaN NA NA -## k2 0.0589 NaN NA NA -## g 0.6473 NaN NA NA -## sigma 3.4323 NaN NaN NaN -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 11.8 39.1 11.80 -## IORE 12.9 31.4 9.46 -## DFOP 11.8 39.1 11.80 -## -## Representative half-life: -## [1] 9.46</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 58.90242 19.06353 58.90242 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 51.51756</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.6840 0.00039 85.9388 109.4292</span> +<span class="co">## k_parent 0.0589 0.00261 0.0431 0.0805</span> +<span class="co">## sigma 3.4323 0.04356 -1.2377 8.1023</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 95.523 0.0055 74.539157 116.51</span> +<span class="co">## k__iore_parent 0.333 0.1433 0.000717 154.57</span> +<span class="co">## N_parent 0.568 0.0677 -0.989464 2.13</span> +<span class="co">## sigma 1.953 0.0975 -5.893100 9.80</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.6840 NaN NaN NaN</span> +<span class="co">## k1 0.0589 NaN NA NA</span> +<span class="co">## k2 0.0589 NaN NA NA</span> +<span class="co">## g 0.6473 NaN NA NA</span> +<span class="co">## sigma 3.4323 NaN NaN NaN</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 11.8 39.1 11.80</span> +<span class="co">## IORE 12.9 31.4 9.46</span> +<span class="co">## DFOP 11.8 39.1 11.80</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 9.46</span></code></pre> </div> -<div id="example-on-page-13" class="section level2"> -<h2 class="hasAnchor"> -<a href="#example-on-page-13" class="anchor"></a>Example on page 13</h2> +<div class="section level3"> +<h3 id="example-on-page-13">Example on page 13<a class="anchor" aria-label="anchor" href="#example-on-page-13"></a> +</h3> <div class="sourceCode" id="cb83"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p13</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p13"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb86"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p13-1.png" width="700"></p> <div class="sourceCode" id="cb87"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 174.5971 142.3951 174.5971 -## -## Critical sum of squares for checking the SFO model: -## [1] 172.131 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 92.73500 5.99e-17 89.61936 95.85065 -## k_parent 0.00258 2.42e-09 0.00223 0.00299 -## sigma 3.41172 7.07e-05 2.05455 4.76888 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 91.6016 6.34e-16 88.53086 94.672 -## k__iore_parent 0.0396 2.36e-01 0.00207 0.759 -## N_parent 0.3541 1.46e-01 -0.35153 1.060 -## sigma 3.0811 9.64e-05 1.84296 4.319 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 92.73500 NA 8.95e+01 95.92118 -## k1 0.00258 NA 4.14e-04 0.01611 -## k2 0.00258 NA 1.74e-03 0.00383 -## g 0.16452 NA 0.00e+00 1.00000 -## sigma 3.41172 NA 2.02e+00 4.79960 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 269 892 269 -## IORE 261 560 169 -## DFOP 269 892 269 -## -## Representative half-life: -## [1] 168.51</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 174.5971 142.3951 174.5971 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 172.131</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 92.73500 5.99e-17 89.61936 95.85065</span> +<span class="co">## k_parent 0.00258 2.42e-09 0.00223 0.00299</span> +<span class="co">## sigma 3.41172 7.07e-05 2.05455 4.76888</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 91.6016 6.34e-16 88.53086 94.672</span> +<span class="co">## k__iore_parent 0.0396 2.36e-01 0.00207 0.759</span> +<span class="co">## N_parent 0.3541 1.46e-01 -0.35153 1.060</span> +<span class="co">## sigma 3.0811 9.64e-05 1.84296 4.319</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 92.73500 NA 8.95e+01 95.92118</span> +<span class="co">## k1 0.00258 NA 4.14e-04 0.01611</span> +<span class="co">## k2 0.00258 NA 1.74e-03 0.00383</span> +<span class="co">## g 0.16452 NA 0.00e+00 1.00000</span> +<span class="co">## sigma 3.41172 NA 2.02e+00 4.79960</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 269 892 269</span> +<span class="co">## IORE 261 560 169</span> +<span class="co">## DFOP 269 892 269</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 168.51</span></code></pre> </div> </div> -<div id="dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf" class="section level1"> -<h1 class="hasAnchor"> -<a href="#dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf" class="anchor"></a>DT50 not observed in the study and DFOP problems in PestDF</h1> +<div class="section level2"> +<h2 id="dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf">DT50 not observed in the study and DFOP problems in PestDF<a class="anchor" aria-label="anchor" href="#dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf"></a> +</h2> <div class="sourceCode" id="cb89"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p14</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p14"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb95"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p14-1.png" width="700"></p> <div class="sourceCode" id="cb96"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 48.43249 28.67746 27.26248 -## -## Critical sum of squares for checking the SFO model: -## [1] 32.83337 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 99.47124 2.06e-30 98.42254 1.01e+02 -## k_parent 0.00279 3.75e-15 0.00256 3.04e-03 -## sigma 1.55616 3.81e-06 1.03704 2.08e+00 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 1.00e+02 NA NaN NaN -## k__iore_parent 9.44e-08 NA NaN NaN -## N_parent 3.31e+00 NA NaN NaN -## sigma 1.20e+00 NA 0.796 1.6 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 1.00e+02 2.96e-28 99.40280 101.2768 -## k1 9.53e-03 1.20e-01 0.00638 0.0143 -## k2 6.08e-12 5.00e-01 0.00000 Inf -## g 3.98e-01 2.19e-01 0.30481 0.4998 -## sigma 1.17e+00 7.68e-06 0.77406 1.5610 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 2.48e+02 8.25e+02 2.48e+02 -## IORE 4.34e+02 2.22e+04 6.70e+03 -## DFOP 3.05e+10 2.95e+11 1.14e+11 -## -## Representative half-life: -## [1] 6697.44</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 48.43249 28.67746 27.26248 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 32.83337</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 99.47124 2.06e-30 98.42254 1.01e+02</span> +<span class="co">## k_parent 0.00279 3.75e-15 0.00256 3.04e-03</span> +<span class="co">## sigma 1.55616 3.81e-06 1.03704 2.08e+00</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.00e+02 NA NaN NaN</span> +<span class="co">## k__iore_parent 9.44e-08 NA NaN NaN</span> +<span class="co">## N_parent 3.31e+00 NA NaN NaN</span> +<span class="co">## sigma 1.20e+00 NA 0.796 1.6</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.00e+02 2.96e-28 99.40280 101.2768</span> +<span class="co">## k1 9.53e-03 1.20e-01 0.00638 0.0143</span> +<span class="co">## k2 6.08e-12 5.00e-01 0.00000 Inf</span> +<span class="co">## g 3.98e-01 2.19e-01 0.30481 0.4998</span> +<span class="co">## sigma 1.17e+00 7.68e-06 0.77406 1.5610</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 2.48e+02 8.25e+02 2.48e+02</span> +<span class="co">## IORE 4.34e+02 2.22e+04 6.70e+03</span> +<span class="co">## DFOP 3.05e+10 2.95e+11 1.14e+11</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 6697.44</span></code></pre> <p>The slower rate constant reported by PestDF is negative, which is not physically realistic, and not possible in mkin. The other fits give the same results in mkin and PestDF.</p> </div> -<div id="n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero" class="section level1"> -<h1 class="hasAnchor"> -<a href="#n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero" class="anchor"></a>N is less than 1 and DFOP fraction parameter is below zero</h1> +<div class="section level2"> +<h2 id="n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero">N is less than 1 and DFOP fraction parameter is below zero<a class="anchor" aria-label="anchor" href="#n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero"></a> +</h2> <div class="sourceCode" id="cb98"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p15a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p15a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb101"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p15a-1.png" width="700"></p> <div class="sourceCode" id="cb102"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 245.5248 135.0132 245.5248 -## -## Critical sum of squares for checking the SFO model: -## [1] 165.9335 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 97.96751 2.00e-15 94.32049 101.615 -## k_parent 0.00952 4.93e-09 0.00824 0.011 -## sigma 4.18778 1.28e-04 2.44588 5.930 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 95.874 2.94e-15 92.937 98.811 -## k__iore_parent 0.629 2.11e-01 0.044 8.982 -## N_parent 0.000 5.00e-01 -0.642 0.642 -## sigma 3.105 1.78e-04 1.795 4.416 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 97.96751 2.85e-13 94.21913 101.7159 -## k1 0.00952 6.28e-02 0.00250 0.0363 -## k2 0.00952 1.27e-04 0.00646 0.0140 -## g 0.21241 5.00e-01 0.00000 1.0000 -## sigma 4.18778 2.50e-04 2.39747 5.9781 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 72.8 242 72.8 -## IORE 76.3 137 41.3 -## DFOP 72.8 242 72.8 -## -## Representative half-life: -## [1] 41.33</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 245.5248 135.0132 245.5248 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 165.9335</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.96751 2.00e-15 94.32049 101.615</span> +<span class="co">## k_parent 0.00952 4.93e-09 0.00824 0.011</span> +<span class="co">## sigma 4.18778 1.28e-04 2.44588 5.930</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 95.874 2.94e-15 92.937 98.811</span> +<span class="co">## k__iore_parent 0.629 2.11e-01 0.044 8.982</span> +<span class="co">## N_parent 0.000 5.00e-01 -0.642 0.642</span> +<span class="co">## sigma 3.105 1.78e-04 1.795 4.416</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 97.96751 2.85e-13 94.21913 101.7159</span> +<span class="co">## k1 0.00952 6.28e-02 0.00250 0.0363</span> +<span class="co">## k2 0.00952 1.27e-04 0.00646 0.0140</span> +<span class="co">## g 0.21241 5.00e-01 0.00000 1.0000</span> +<span class="co">## sigma 4.18778 2.50e-04 2.39747 5.9781</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 72.8 242 72.8</span> +<span class="co">## IORE 76.3 137 41.3</span> +<span class="co">## DFOP 72.8 242 72.8</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 41.33</span></code></pre> <div class="sourceCode" id="cb104"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p15b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p15b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## Warning in sqrt(diag(covar)): NaNs produced</code></pre> -<pre><code>## Warning in sqrt(1/diag(V)): NaNs produced</code></pre> -<pre><code>## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is -## doubtful</code></pre> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The half-life obtained from the IORE model may be used</code></pre> +<pre><code><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></code></pre> +<pre><code><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result is</span> +<span class="co">## doubtful</span></code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The half-life obtained from the IORE model may be used</span></code></pre> <div class="sourceCode" id="cb110"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p15b-1.png" width="700"></p> <div class="sourceCode" id="cb111"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 106.91629 68.55574 106.91629 -## -## Critical sum of squares for checking the SFO model: -## [1] 84.25618 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 1.01e+02 3.06e-17 98.31594 1.03e+02 -## k_parent 4.86e-03 2.48e-10 0.00435 5.42e-03 -## sigma 2.76e+00 1.28e-04 1.61402 3.91e+00 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 99.83 1.81e-16 97.51349 102.14 -## k__iore_parent 0.38 3.22e-01 0.00352 41.05 -## N_parent 0.00 5.00e-01 -1.07696 1.08 -## sigma 2.21 2.57e-04 1.23245 3.19 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 1.01e+02 NA 9.82e+01 1.04e+02 -## k1 4.86e-03 NA 8.63e-04 2.73e-02 -## k2 4.86e-03 NA 3.21e-03 7.35e-03 -## g 1.88e-01 NA NA NA -## sigma 2.76e+00 NA 1.58e+00 3.94e+00 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 143 474 143.0 -## IORE 131 236 71.2 -## DFOP 143 474 143.0 -## -## Representative half-life: -## [1] 71.18</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 106.91629 68.55574 106.91629 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 84.25618</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.01e+02 3.06e-17 98.31594 1.03e+02</span> +<span class="co">## k_parent 4.86e-03 2.48e-10 0.00435 5.42e-03</span> +<span class="co">## sigma 2.76e+00 1.28e-04 1.61402 3.91e+00</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 99.83 1.81e-16 97.51349 102.14</span> +<span class="co">## k__iore_parent 0.38 3.22e-01 0.00352 41.05</span> +<span class="co">## N_parent 0.00 5.00e-01 -1.07696 1.08</span> +<span class="co">## sigma 2.21 2.57e-04 1.23245 3.19</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 1.01e+02 NA 9.82e+01 1.04e+02</span> +<span class="co">## k1 4.86e-03 NA 8.63e-04 2.73e-02</span> +<span class="co">## k2 4.86e-03 NA 3.21e-03 7.35e-03</span> +<span class="co">## g 1.88e-01 NA NA NA</span> +<span class="co">## sigma 2.76e+00 NA 1.58e+00 3.94e+00</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 143 474 143.0</span> +<span class="co">## IORE 131 236 71.2</span> +<span class="co">## DFOP 143 474 143.0</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 71.18</span></code></pre> <p>In mkin, only the IORE fit is affected (deemed unrealistic), as the fraction parameter of the DFOP model is restricted to the interval between 0 and 1 in mkin. The SFO fits give the same results for both mkin and PestDF.</p> </div> -<div id="the-dfop-fraction-parameter-is-greater-than-1" class="section level1"> -<h1 class="hasAnchor"> -<a href="#the-dfop-fraction-parameter-is-greater-than-1" class="anchor"></a>The DFOP fraction parameter is greater than 1</h1> +<div class="section level2"> +<h2 id="the-dfop-fraction-parameter-is-greater-than-1">The DFOP fraction parameter is greater than 1<a class="anchor" aria-label="anchor" href="#the-dfop-fraction-parameter-is-greater-than-1"></a> +</h2> <div class="sourceCode" id="cb113"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">p16</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p16"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></code></pre></div> -<pre><code>## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</code></pre> -<pre><code>## The representative half-life of the IORE model is longer than the one corresponding</code></pre> -<pre><code>## to the terminal degradation rate found with the DFOP model.</code></pre> -<pre><code>## The representative half-life obtained from the DFOP model may be used</code></pre> +<pre><code><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></code></pre> +<pre><code><span class="co">## The representative half-life of the IORE model is longer than the one corresponding</span></code></pre> +<pre><code><span class="co">## to the terminal degradation rate found with the DFOP model.</span></code></pre> +<pre><code><span class="co">## The representative half-life obtained from the DFOP model may be used</span></code></pre> <div class="sourceCode" id="cb118"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html">plot</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></code></pre></div> <p><img src="NAFTA_examples_files/figure-html/p16-1.png" width="700"></p> <div class="sourceCode" id="cb119"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></code></pre></div> -<pre><code>## Sums of squares: -## SFO IORE DFOP -## 3831.804 2062.008 1550.980 -## -## Critical sum of squares for checking the SFO model: -## [1] 2247.348 -## -## Parameters: -## $SFO -## Estimate Pr(>t) Lower Upper -## parent_0 71.953 2.33e-13 60.509 83.40 -## k_parent 0.159 4.86e-05 0.102 0.25 -## sigma 11.302 1.25e-08 8.308 14.30 -## -## $IORE -## Estimate Pr(>t) Lower Upper -## parent_0 8.74e+01 2.48e-16 7.72e+01 97.52972 -## k__iore_parent 4.55e-04 2.16e-01 3.48e-05 0.00595 -## N_parent 2.70e+00 1.21e-08 1.99e+00 3.40046 -## sigma 8.29e+00 1.61e-08 6.09e+00 10.49062 -## -## $DFOP -## Estimate Pr(>t) Lower Upper -## parent_0 88.5333 7.40e-18 79.9836 97.083 -## k1 18.8461 5.00e-01 0.0000 Inf -## k2 0.0776 1.41e-05 0.0518 0.116 -## g 0.4733 1.41e-09 0.3674 0.582 -## sigma 7.1902 2.11e-08 5.2785 9.102 -## -## -## DTx values: -## DT50 DT90 DT50_rep -## SFO 4.35 14.4 4.35 -## IORE 1.48 32.1 9.67 -## DFOP 0.67 21.4 8.93 -## -## Representative half-life: -## [1] 8.93</code></pre> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></code></pre></div> +<pre><code><span class="co">## Sums of squares:</span> +<span class="co">## SFO IORE DFOP </span> +<span class="co">## 3831.804 2062.008 1550.980 </span> +<span class="co">## </span> +<span class="co">## Critical sum of squares for checking the SFO model:</span> +<span class="co">## [1] 2247.348</span> +<span class="co">## </span> +<span class="co">## Parameters:</span> +<span class="co">## $SFO</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 71.953 2.33e-13 60.509 83.40</span> +<span class="co">## k_parent 0.159 4.86e-05 0.102 0.25</span> +<span class="co">## sigma 11.302 1.25e-08 8.308 14.30</span> +<span class="co">## </span> +<span class="co">## $IORE</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 8.74e+01 2.48e-16 7.72e+01 97.52972</span> +<span class="co">## k__iore_parent 4.55e-04 2.16e-01 3.48e-05 0.00595</span> +<span class="co">## N_parent 2.70e+00 1.21e-08 1.99e+00 3.40046</span> +<span class="co">## sigma 8.29e+00 1.61e-08 6.09e+00 10.49062</span> +<span class="co">## </span> +<span class="co">## $DFOP</span> +<span class="co">## Estimate Pr(>t) Lower Upper</span> +<span class="co">## parent_0 88.5333 7.40e-18 79.9836 97.083</span> +<span class="co">## k1 18.8461 5.00e-01 0.0000 Inf</span> +<span class="co">## k2 0.0776 1.41e-05 0.0518 0.116</span> +<span class="co">## g 0.4733 1.41e-09 0.3674 0.582</span> +<span class="co">## sigma 7.1902 2.11e-08 5.2785 9.102</span> +<span class="co">## </span> +<span class="co">## </span> +<span class="co">## DTx values:</span> +<span class="co">## DT50 DT90 DT50_rep</span> +<span class="co">## SFO 4.35 14.4 4.35</span> +<span class="co">## IORE 1.48 32.1 9.67</span> +<span class="co">## DFOP 0.67 21.4 8.93</span> +<span class="co">## </span> +<span class="co">## Representative half-life:</span> +<span class="co">## [1] 8.93</span></code></pre> <p>In PestDF, the DFOP fit seems to have stuck in a local minimum, as mkin finds a solution with a much lower <span class="math inline">\(\chi^2\)</span> error level. As the half-life from the slower rate constant of the DFOP model is larger than the IORE derived half-life, the NAFTA recommendation obtained with mkin is to use the DFOP representative half-life of 8.9 days.</p> </div> -<div id="conclusions" class="section level1"> -<h1 class="hasAnchor"> -<a href="#conclusions" class="anchor"></a>Conclusions</h1> +<div class="section level2"> +<h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#conclusions"></a> +</h2> <p>The results obtained with mkin deviate from the results obtained with PestDF either in cases where one of the interpretive rules would apply, i.e. the IORE parameter N is less than one or the DFOP k values obtained with PestDF are equal to the SFO k values, or in cases where the DFOP model did not converge, which often lead to negative rate constants returned by PestDF.</p> <p>Therefore, mkin appears to suitable for kinetic evaluations according to the NAFTA guidance.</p> </div> -<div id="references" class="section level1 unnumbered"> -<h1 class="hasAnchor"> -<a href="#references" class="anchor"></a>References</h1> +<div class="section level2"> +<h2 class="unnumbered" id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> <div id="refs" class="references hanging-indent"> <div id="ref-usepa2015"> <p>US EPA. 2015. “Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-Life Values and Characterizing Pesticide Degradation.”</p> @@ -1015,11 +1020,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -1028,5 +1035,7 @@ + + </body> </html> diff --git 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template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,15 +99,15 @@ - </header><script src="benchmarks_files/header-attrs-2.7/header-attrs.js"></script><script src="benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Benchmark timings for mkin</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">Last change 13 May 2020 (rebuilt 2021-03-31)</h4> + <h4 data-toc-skip class="date">Last change 13 May 2020 (rebuilt 2022-03-02)</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/web_only/benchmarks.rmd"><code>vignettes/web_only/benchmarks.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/benchmarks.rmd" class="external-link"><code>vignettes/web_only/benchmarks.rmd</code></a></small> <div class="hidden name"><code>benchmarks.rmd</code></div> </div> @@ -110,17 +115,17 @@ <p>Each system is characterized by its CPU type, the operating system type and the mkin version. Currently only values for one system are available. A compiler was available, so if no analytical solution was available, compiled ODE models are used.</p> -<div id="test-cases" class="section level2"> -<h2 class="hasAnchor"> -<a href="#test-cases" class="anchor"></a>Test cases</h2> +<div class="section level2"> +<h2 id="test-cases">Test cases<a class="anchor" aria-label="anchor" href="#test-cases"></a> +</h2> <p>Parent only:</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> <code class="sourceCode R"><span class="va">FOCUS_C</span> <span class="op"><-</span> <span class="va">FOCUS_2006_C</span> -<span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> -<span class="va">parent_datasets</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">FOCUS_C</span>, <span class="va">FOCUS_D</span><span class="op">)</span> +<span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> +<span class="va">parent_datasets</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_C</span>, <span class="va">FOCUS_D</span><span class="op">)</span> -<span class="va">t1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span>, +<span class="va">t1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> +<span class="va">t2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></code></pre></div> <p>One metabolite:</p> <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> @@ -133,10 +138,10 @@ <span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span> -<span class="va">t3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t4</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>, +<span class="va">t3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> +<span class="va">t4</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t5</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>, +<span class="va">t5</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></code></pre></div> <p>Two metabolites, synthetic data:</p> <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> @@ -145,7 +150,7 @@ M2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> -<span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>, +<span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>, M1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, M2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> @@ -154,31 +159,31 @@ <span class="va">DFOP_par_c</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span> -<span class="va">t6</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t7</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> +<span class="va">t6</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> +<span class="va">t7</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t8</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>, +<span class="va">t8</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t9</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>, +<span class="va">t9</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t10</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>, +<span class="va">t10</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span> -<span class="va">t11</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>, +<span class="va">t11</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></code></pre></div> <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">mkin_benchmarks</span><span class="op">[</span><span class="va">system_string</span>, <span class="fu"><a href="https://rdrr.io/r/base/paste.html">paste0</a></span><span class="op">(</span><span class="st">"t"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">11</span><span class="op">)</span><span class="op">]</span> <span class="op"><-</span> - <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="va">t1</span>, <span class="va">t2</span>, <span class="va">t3</span>, <span class="va">t4</span>, <span class="va">t5</span>, <span class="va">t6</span>, <span class="va">t7</span>, <span class="va">t8</span>, <span class="va">t9</span>, <span class="va">t10</span>, <span class="va">t11</span><span class="op">)</span> -<span class="fu"><a href="https://rdrr.io/r/base/save.html">save</a></span><span class="op">(</span><span class="va">mkin_benchmarks</span>, file <span class="op">=</span> <span class="st">"~/git/mkin/vignettes/web_only/mkin_benchmarks.rda"</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="va">mkin_benchmarks</span><span class="op">[</span><span class="va">system_string</span>, <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"t"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">11</span><span class="op">)</span><span class="op">]</span> <span class="op"><-</span> + <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="va">t1</span>, <span class="va">t2</span>, <span class="va">t3</span>, <span class="va">t4</span>, <span class="va">t5</span>, <span class="va">t6</span>, <span class="va">t7</span>, <span class="va">t8</span>, <span class="va">t9</span>, <span class="va">t10</span>, <span class="va">t11</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/save.html" class="external-link">save</a></span><span class="op">(</span><span class="va">mkin_benchmarks</span>, file <span class="op">=</span> <span class="st">"~/git/mkin/vignettes/web_only/mkin_benchmarks.rda"</span><span class="op">)</span></code></pre></div> </div> -<div id="results" class="section level2"> -<h2 class="hasAnchor"> -<a href="#results" class="anchor"></a>Results</h2> +<div class="section level2"> +<h2 id="results">Results<a class="anchor" aria-label="anchor" href="#results"></a> +</h2> <p>Currently, we only have benchmark information on one system, therefore only the mkin version is shown with the results below. Timings are in seconds, shorter is better. All results were obtained by serial, i.e. not using multiple computing cores.</p> <p>Benchmarks for all available error models are shown.</p> -<div id="parent-only" class="section level3"> -<h3 class="hasAnchor"> -<a href="#parent-only" class="anchor"></a>Parent only</h3> +<div class="section level3"> +<h3 id="parent-only">Parent only<a class="anchor" aria-label="anchor" href="#parent-only"></a> +</h3> <p>Constant variance (t1) and two-component error model (t2) for four models fitted to two datasets, i.e. eight fits for each test.</p> <table class="table"> <thead><tr class="header"> @@ -237,12 +242,17 @@ <td align="right">1.867</td> <td align="right">3.450</td> </tr> +<tr class="odd"> +<td align="left">1.1.0</td> +<td align="right">1.938</td> +<td align="right">3.517</td> +</tr> </tbody> </table> </div> -<div id="one-metabolite" class="section level3"> -<h3 class="hasAnchor"> -<a href="#one-metabolite" class="anchor"></a>One metabolite</h3> +<div class="section level3"> +<h3 id="one-metabolite">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite"></a> +</h3> <p>Constant variance (t3), two-component error model (t4), and variance by variable (t5) for three models fitted to one dataset, i.e. three fits for each test.</p> <table class="table"> <thead><tr class="header"> @@ -312,12 +322,18 @@ <td align="right">6.364</td> <td align="right">2.820</td> </tr> +<tr class="odd"> +<td align="left">1.1.0</td> +<td align="right">1.470</td> +<td align="right">6.508</td> +<td align="right">2.894</td> +</tr> </tbody> </table> </div> -<div id="two-metabolites" class="section level3"> -<h3 class="hasAnchor"> -<a href="#two-metabolites" class="anchor"></a>Two metabolites</h3> +<div class="section level3"> +<h3 id="two-metabolites">Two metabolites<a class="anchor" aria-label="anchor" href="#two-metabolites"></a> +</h3> <p>Constant variance (t6 and t7), two-component error model (t8 and t9), and variance by variable (t10 and t11) for one model fitted to one dataset, i.e. one fit for each test.</p> <table class="table"> <thead><tr class="header"> @@ -420,6 +436,15 @@ <td align="right">1.936</td> <td align="right">2.826</td> </tr> +<tr class="odd"> +<td align="left">1.1.0</td> +<td align="right">0.810</td> +<td align="right">1.264</td> +<td align="right">1.503</td> +<td align="right">3.096</td> +<td align="right">1.984</td> +<td align="right">2.847</td> +</tr> </tbody> </table> </div> @@ -437,11 +462,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -450,5 +477,7 @@ + + </body> </html> diff --git a/docs/articles/web_only/compiled_models.html b/docs/articles/web_only/compiled_models.html index ce8d8481..35ea6f27 100644 --- a/docs/articles/web_only/compiled_models.html +++ b/docs/articles/web_only/compiled_models.html @@ -19,6 +19,8 @@ <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-article"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -31,7 +33,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -57,6 +59,9 @@ <a href="../../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -79,7 +84,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -94,53 +99,53 @@ - </header><script src="compiled_models_files/header-attrs-2.6/header-attrs.js"></script><script src="compiled_models_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + </header><script src="compiled_models_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> <div class="col-md-9 contents"> <div class="page-header toc-ignore"> <h1 data-toc-skip>Performance benefit by using compiled model definitions in mkin</h1> - <h4 class="author">Johannes Ranke</h4> + <h4 data-toc-skip class="author">Johannes Ranke</h4> - <h4 class="date">2021-02-15</h4> + <h4 data-toc-skip class="date">2022-03-02</h4> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/master/vignettes/web_only/compiled_models.rmd"><code>vignettes/web_only/compiled_models.rmd</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/compiled_models.rmd" class="external-link"><code>vignettes/web_only/compiled_models.rmd</code></a></small> <div class="hidden name"><code>compiled_models.rmd</code></div> </div> -<div id="how-to-benefit-from-compiled-models" class="section level2"> -<h2 class="hasAnchor"> -<a href="#how-to-benefit-from-compiled-models" class="anchor"></a>How to benefit from compiled models</h2> +<div class="section level2"> +<h2 id="how-to-benefit-from-compiled-models">How to benefit from compiled models<a class="anchor" aria-label="anchor" href="#how-to-benefit-from-compiled-models"></a> +</h2> <p>When using an mkin version equal to or greater than 0.9-36 and a C compiler is available, you will see a message that the model is being compiled from autogenerated C code when defining a model using mkinmod. Starting from version 0.9.49.9, the <code><a href="../../reference/mkinmod.html">mkinmod()</a></code> function checks for presence of a compiler using</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu">pkgbuild</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/pkgbuild/man/has_compiler.html">has_compiler</a></span><span class="op">(</span><span class="op">)</span></code></pre></div> -<p>In previous versions, it used <code><a href="https://rdrr.io/r/base/Sys.which.html">Sys.which("gcc")</a></code> for this check.</p> +<code class="sourceCode R"><span class="fu">pkgbuild</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/pkgbuild/man/has_compiler.html" class="external-link">has_compiler</a></span><span class="op">(</span><span class="op">)</span></code></pre></div> +<p>In previous versions, it used <code>Sys.which("gcc")</code> for this check.</p> <p>On Linux, you need to have the essential build tools like make and gcc or clang installed. On Debian based linux distributions, these will be pulled in by installing the build-essential package.</p> <p>On MacOS, which I do not use personally, I have had reports that a compiler is available by default.</p> <p>On Windows, you need to install Rtools and have the path to its bin directory in your PATH variable. You do not need to modify the PATH variable when installing Rtools. Instead, I would recommend to put the line</p> <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/Sys.setenv.html">Sys.setenv</a></span><span class="op">(</span>PATH <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html">paste</a></span><span class="op">(</span><span class="st">"C:/Rtools/bin"</span>, <span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html">Sys.getenv</a></span><span class="op">(</span><span class="st">"PATH"</span><span class="op">)</span>, sep<span class="op">=</span><span class="st">";"</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/Sys.setenv.html" class="external-link">Sys.setenv</a></span><span class="op">(</span>PATH <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"C:/Rtools/bin"</span>, <span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"PATH"</span><span class="op">)</span>, sep<span class="op">=</span><span class="st">";"</span><span class="op">)</span><span class="op">)</span></code></pre></div> <p>into your .Rprofile startup file. This is just a text file with some R code that is executed when your R session starts. It has to be named .Rprofile and has to be located in your home directory, which will generally be your Documents folder. You can check the location of the home directory used by R by issuing</p> <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html">Sys.getenv</a></span><span class="op">(</span><span class="st">"HOME"</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"HOME"</span><span class="op">)</span></code></pre></div> </div> -<div id="comparison-with-other-solution-methods" class="section level2"> -<h2 class="hasAnchor"> -<a href="#comparison-with-other-solution-methods" class="anchor"></a>Comparison with other solution methods</h2> +<div class="section level2"> +<h2 id="comparison-with-other-solution-methods">Comparison with other solution methods<a class="anchor" aria-label="anchor" href="#comparison-with-other-solution-methods"></a> +</h2> <p>First, we build a simple degradation model for a parent compound with one metabolite, and we remove zero values from the dataset.</p> <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> <div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></code></pre></div> <p>We can compare the performance of the Eigenvalue based solution against the compiled version and the R implementation of the differential equations using the benchmark package. In the output of below code, the warnings about zero being removed from the FOCUS D dataset are suppressed. Since mkin version 0.9.49.11, an analytical solution is also implemented, which is included in the tests below.</p> <div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span> - <span class="va">b.1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html">benchmark</a></span><span class="op">(</span> +<code class="sourceCode R"><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span> + <span class="va">b.1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span> <span class="st">"deSolve, not compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>, @@ -152,50 +157,50 @@ solution_type <span class="op">=</span> <span class="st">"analytical"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>, replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>, - columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span> - <span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">b.1</span><span class="op">)</span> + columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span> + <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">b.1</span><span class="op">)</span> <span class="op">}</span> <span class="kw">else</span> <span class="op">{</span> - <span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="st">"R package rbenchmark is not available"</span><span class="op">)</span> + <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="st">"R package rbenchmark is not available"</span><span class="op">)</span> <span class="op">}</span></code></pre></div> -<pre><code>## test replications relative elapsed -## 4 analytical 1 1.000 0.181 -## 3 deSolve, compiled 1 1.812 0.328 -## 2 Eigenvalue based 1 2.088 0.378 -## 1 deSolve, not compiled 1 45.923 8.312</code></pre> +<pre><code><span class="co">## test replications relative elapsed</span> +<span class="co">## 4 analytical 1 1.000 0.216</span> +<span class="co">## 3 deSolve, compiled 1 1.708 0.369</span> +<span class="co">## 2 Eigenvalue based 1 1.866 0.403</span> +<span class="co">## 1 deSolve, not compiled 1 34.009 7.346</span></code></pre> <p>We see that using the compiled model is by more than a factor of 10 faster than using deSolve without compiled code.</p> </div> -<div id="model-without-analytical-solution" class="section level2"> -<h2 class="hasAnchor"> -<a href="#model-without-analytical-solution" class="anchor"></a>Model without analytical solution</h2> +<div class="section level2"> +<h2 id="model-without-analytical-solution">Model without analytical solution<a class="anchor" aria-label="anchor" href="#model-without-analytical-solution"></a> +</h2> <p>This evaluation is also taken from the example section of mkinfit. No analytical solution is available for this system, and now Eigenvalue based solution is possible, so only deSolve using with or without compiled code is available.</p> <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span> +<code class="sourceCode R"><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span> <span class="va">FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span> - <span class="va">b.2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html">benchmark</a></span><span class="op">(</span> + <span class="va">b.2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span> <span class="st">"deSolve, not compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>, <span class="st">"deSolve, compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>, replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>, - columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span> - <span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">)</span> - <span class="va">factor_FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html">round</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">[</span><span class="st">"1"</span>, <span class="st">"relative"</span><span class="op">]</span><span class="op">)</span> + columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span> + <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">)</span> + <span class="va">factor_FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">[</span><span class="st">"1"</span>, <span class="st">"relative"</span><span class="op">]</span><span class="op">)</span> <span class="op">}</span> <span class="kw">else</span> <span class="op">{</span> <span class="va">factor_FOMC_SFO</span> <span class="op"><-</span> <span class="cn">NA</span> - <span class="fu"><a href="https://rdrr.io/r/base/print.html">print</a></span><span class="op">(</span><span class="st">"R package benchmark is not available"</span><span class="op">)</span> + <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="st">"R package benchmark is not available"</span><span class="op">)</span> <span class="op">}</span></code></pre></div> -<pre><code>## Temporary DLL for differentials generated and loaded</code></pre> -<pre><code>## test replications relative elapsed -## 2 deSolve, compiled 1 1.000 0.486 -## 1 deSolve, not compiled 1 31.597 15.356</code></pre> -<p>Here we get a performance benefit of a factor of 32 using the version of the differential equation model compiled from C code!</p> -<p>This vignette was built with mkin 1.0.3 on</p> -<pre><code>## R version 4.0.3 (2020-10-10) -## Platform: x86_64-pc-linux-gnu (64-bit) -## Running under: Debian GNU/Linux bullseye/sid</code></pre> -<pre><code>## CPU model: AMD Ryzen 7 1700 Eight-Core Processor</code></pre> +<pre><code><span class="co">## Temporary DLL for differentials generated and loaded</span></code></pre> +<pre><code><span class="co">## test replications relative elapsed</span> +<span class="co">## 2 deSolve, compiled 1 1.000 0.533</span> +<span class="co">## 1 deSolve, not compiled 1 25.146 13.403</span></code></pre> +<p>Here we get a performance benefit of a factor of 25 using the version of the differential equation model compiled from C code!</p> +<p>This vignette was built with mkin 1.1.0 on</p> +<pre><code><span class="co">## R version 4.1.2 (2021-11-01)</span> +<span class="co">## Platform: x86_64-pc-linux-gnu (64-bit)</span> +<span class="co">## Running under: Debian GNU/Linux 11 (bullseye)</span></code></pre> +<pre><code><span class="co">## CPU model: AMD Ryzen 7 1700 Eight-Core Processor</span></code></pre> </div> </div> @@ -210,11 +215,13 @@ <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" 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src="dimethenamid_2018_files/accessible-code-block-0.0.1/empty-anchor.js"></script><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header toc-ignore"> + <h1 data-toc-skip>Example evaluations of the dimethenamid data from 2018</h1> + <h4 data-toc-skip class="author">Johannes Ranke</h4> + + <h4 data-toc-skip class="date">Last change 10 February 2022, built on 02 Mär 2022</h4> + + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/dimethenamid_2018.rmd" class="external-link"><code>vignettes/web_only/dimethenamid_2018.rmd</code></a></small> + <div class="hidden name"><code>dimethenamid_2018.rmd</code></div> + + </div> + + + +<p><a href="http://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher Str. 12, 79639 Grenzach-Wyhlen, Germany</a></p> +<div class="section level2"> +<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> +</h2> +<p>During the preparation of the journal article on nonlinear mixed-effects models in degradation kinetics <span class="citation">(Ranke et al. 2021)</span> and the analysis of the dimethenamid degradation data analysed therein, a need for a more detailed analysis using not only nlme and saemix, but also nlmixr for fitting the mixed-effects models was identified, as many model variants do not converge when fitted with nlme, and not all relevant error models can be fitted with saemix.</p> +<p>This vignette is an attempt to satisfy this need.</p> +</div> +<div class="section level2"> +<h2 id="data">Data<a class="anchor" aria-label="anchor" href="#data"></a> +</h2> +<p>Residue data forming the basis for the endpoints derived in the conclusion on the peer review of the pesticide risk assessment of dimethenamid-P published by the European Food Safety Authority (EFSA) in 2018 <span class="citation">(EFSA 2018)</span> were transcribed from the risk assessment report <span class="citation">(Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria 2018)</span> which can be downloaded from the Open EFSA repository <a href="https://open.efsa.europa.eu" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a>.</p> +<p>The data are <a href="https://pkgdown.jrwb.de/mkin/reference/dimethenamid_2018.html">available in the mkin package</a>. The following code (hidden by default, please use the button to the right to show it) treats the data available for the racemic mixture dimethenamid (DMTA) and its enantiomer dimethenamid-P (DMTAP) in the same way, as no difference between their degradation behaviour was identified in the EU risk assessment. The observation times of each dataset are multiplied with the corresponding normalisation factor also available in the dataset, in order to make it possible to describe all datasets with a single set of parameters.</p> +<p>Also, datasets observed in the same soil are merged, resulting in dimethenamid (DMTA) data from six soils.</p> +<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span> + <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span> + <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span> + <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span> + <span class="va">ds_i</span> +<span class="op">}</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span> +<span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> +<span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span> +<span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></code></pre></div> +</div> +<div class="section level2"> +<h2 id="parent-degradation">Parent degradation<a class="anchor" aria-label="anchor" href="#parent-degradation"></a> +</h2> +<p>We evaluate the observed degradation of the parent compound using simple exponential decline (SFO) and biexponential decline (DFOP), using constant variance (const) and a two-component variance (tc) as error models.</p> +<div class="section level3"> +<h3 id="separate-evaluations">Separate evaluations<a class="anchor" aria-label="anchor" href="#separate-evaluations"></a> +</h3> +<p>As a first step, to get a visual impression of the fit of the different models, we do separate evaluations for each soil using the mmkin function from the mkin package:</p> +<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_mkin_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">dmta_ds</span>, + error_model <span class="op">=</span> <span class="st">"const"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> +<span class="va">f_parent_mkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">dmta_ds</span>, + error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> +<p>The plot of the individual SFO fits shown below suggests that at least in some datasets the degradation slows down towards later time points, and that the scatter of the residuals error is smaller for smaller values (panel to the right):</p> +<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_sfo_const-1.png" width="700"></p> +<p>Using biexponential decline (DFOP) results in a slightly more random scatter of the residuals:</p> +<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_const-1.png" width="700"></p> +<p>The population curve (bold line) in the above plot results from taking the mean of the individual transformed parameters, i.e. of log k1 and log k2, as well as of the logit of the g parameter of the DFOP model). Here, this procedure does not result in parameters that represent the degradation well, because in some datasets the fitted value for k2 is extremely close to zero, leading to a log k2 value that dominates the average. This is alleviated if only rate constants that pass the t-test for significant difference from zero (on the untransformed scale) are considered in the averaging:</p> +<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_const_test-1.png" width="700"></p> +<p>While this is visually much more satisfactory, such an average procedure could introduce a bias, as not all results from the individual fits enter the population curve with the same weight. This is where nonlinear mixed-effects models can help out by treating all datasets with equally by fitting a parameter distribution model together with the degradation model and the error model (see below).</p> +<p>The remaining trend of the residuals to be higher for higher predicted residues is reduced by using the two-component error model:</p> +<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_tc_test-1.png" width="700"></p> +<p>However, note that in the case of using this error model, the fits to the Flaach and BBA 2.3 datasets appear to be ill-defined, indicated by the fact that they did not converge:</p> +<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></code></pre></div> +<pre><code><mmkin> object +Status of individual fits: + + dataset +model Calke Borstel Flaach BBA 2.2 BBA 2.3 Elliot + DFOP OK OK C OK C OK + +OK: No warnings +C: Optimisation did not converge: +iteration limit reached without convergence (10)</code></pre> +</div> +<div class="section level3"> +<h3 id="nonlinear-mixed-effects-models">Nonlinear mixed-effects models<a class="anchor" aria-label="anchor" href="#nonlinear-mixed-effects-models"></a> +</h3> +<p>Instead of taking a model selection decision for each of the individual fits, we fit nonlinear mixed-effects models (using different fitting algorithms as implemented in different packages) and do model selection using all available data at the same time. In order to make sure that these decisions are not unduly influenced by the type of algorithm used, by implementation details or by the use of wrong control parameters, we compare the model selection results obtained with different R packages, with different algorithms and checking control parameters.</p> +<div class="section level4"> +<h4 id="nlme">nlme<a class="anchor" aria-label="anchor" href="#nlme"></a> +</h4> +<p>The nlme package was the first R extension providing facilities to fit nonlinear mixed-effects models. We would like to do model selection from all four combinations of degradation models and error models based on the AIC. However, fitting the DFOP model with constant variance and using default control parameters results in an error, signalling that the maximum number of 50 iterations was reached, potentially indicating overparameterisation. Nevertheless, the algorithm converges when the two-component error model is used in combination with the DFOP model. This can be explained by the fact that the smaller residues observed at later sampling times get more weight when using the two-component error model which will counteract the tendency of the algorithm to try parameter combinations unsuitable for fitting these data.</p> +<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span> +<span class="va">f_parent_nlme_sfo_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span> +<span class="co"># f_parent_nlme_dfop_const <- nlme(f_parent_mkin_const["DFOP", ])</span> +<span class="va">f_parent_nlme_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span> +<span class="va">f_parent_nlme_dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></code></pre></div> +<p>Note that a certain degree of overparameterisation is also indicated by a warning obtained when fitting DFOP with the two-component error model (‘false convergence’ in the ‘LME step’ in iteration 3). However, as this warning does not occur in later iterations, and specifically not in the last of the 6 iterations, we can ignore this warning.</p> +<p>The model comparison function of the nlme package can directly be applied to these fits showing a much lower AIC for the DFOP model fitted with the two-component error model. Also, the likelihood ratio test indicates that this difference is significant as the p-value is below 0.0001.</p> +<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span> + <span class="va">f_parent_nlme_sfo_const</span>, <span class="va">f_parent_nlme_sfo_tc</span>, <span class="va">f_parent_nlme_dfop_tc</span> +<span class="op">)</span></code></pre></div> +<pre><code> Model df AIC BIC logLik Test L.Ratio p-value +f_parent_nlme_sfo_const 1 5 796.60 811.82 -393.30 +f_parent_nlme_sfo_tc 2 6 798.60 816.86 -393.30 1 vs 2 0.00 0.998 +f_parent_nlme_dfop_tc 3 10 671.91 702.34 -325.96 2 vs 3 134.69 <.0001</code></pre> +<p>In addition to these fits, attempts were also made to include correlations between random effects by using the log Cholesky parameterisation of the matrix specifying them. The code used for these attempts can be made visible below.</p> +<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlme_sfo_const_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, + random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k_DMTA</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_const</span>, <span class="va">f_parent_nlme_sfo_const_logchol</span><span class="op">)</span> +<span class="va">f_parent_nlme_sfo_tc_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, + random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k_DMTA</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_tc</span>, <span class="va">f_parent_nlme_sfo_tc_logchol</span><span class="op">)</span> +<span class="va">f_parent_nlme_dfop_tc_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, + random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k1</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k2</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">g_qlogis</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span>, <span class="va">f_parent_nlme_dfop_tc_logchol</span><span class="op">)</span></code></pre></div> +<p>While the SFO variants converge fast, the additional parameters introduced by this lead to convergence warnings for the DFOP model. The model comparison clearly show that adding correlations between random effects does not improve the fits.</p> +<p>The selected model (DFOP with two-component error) fitted to the data assuming no correlations between random effects is shown below.</p> +<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/plot_parent_nlme-1.png" width="700"></p> +</div> +<div class="section level4"> +<h4 id="saemix">saemix<a class="anchor" aria-label="anchor" href="#saemix"></a> +</h4> +<p>The saemix package provided the first Open Source implementation of the Stochastic Approximation to the Expectation Maximisation (SAEM) algorithm. SAEM fits of degradation models can be conveniently performed using an interface to the saemix package available in current development versions of the mkin package.</p> +<p>The corresponding SAEM fits of the four combinations of degradation and error models are fitted below. As there is no convergence criterion implemented in the saemix package, the convergence plots need to be manually checked for every fit. As we will compare the SAEM implementation of saemix to the results obtained using the nlmixr package later, we define control settings that work well for all the parent data fits shown in this vignette.</p> +<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span> +<span class="va">saemix_control</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">800</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>, + print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span> +<span class="va">saemix_control_moreiter</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1600</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>, + print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span> +<span class="va">saemix_control_10k</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10000</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>, + print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div> +<p>The convergence plot for the SFO model using constant variance is shown below.</p> +<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_sfo_const</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, + control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_sfo_const-1.png" width="700"></p> +<p>Obviously the default number of iterations is sufficient to reach convergence. This can also be said for the SFO fit using the two-component error model.</p> +<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_sfo_tc</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, + control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_sfo_tc-1.png" width="700"></p> +<p>When fitting the DFOP model with constant variance (see below), parameter convergence is not as unambiguous.</p> +<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_dfop_const</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, + control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_dfop_const-1.png" width="700"></p> +<p>This is improved when the DFOP model is fitted with the two-component error model. Convergence of the variance of k2 is enhanced, it remains more or less stable already after 200 iterations of the first phase.</p> +<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_dfop_tc</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, + control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span> +<span class="va">f_parent_saemix_dfop_tc_moreiter</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, + control <span class="op">=</span> <span class="va">saemix_control_moreiter</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_dfop_tc-1.png" width="700"></p> +<p>Doubling the number of iterations in the first phase of the algorithm leads to a slightly lower likelihood, and therefore to slightly higher AIC and BIC values. With even more iterations, the algorithm stops with an error message. This is related to the variance of k2 approximating zero. This has been submitted as a <a href="https://github.com/saemixdevelopment/saemixextension/issues/29" class="external-link">bug to the saemix package</a>, as the algorithm does not converge in this case.</p> +<p>An alternative way to fit DFOP in combination with the two-component error model is to use the model formulation with transformed parameters as used per default in mkin. When using this option, convergence is slower, but eventually the algorithm stops as well with the same error message.</p> +<p>The four combinations (SFO/const, SFO/tc, DFOP/const and DFOP/tc) and the version with increased iterations can be compared using the model comparison function of the saemix package:</p> +<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">AIC_parent_saemix</span> <span class="op"><-</span> <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span> + <span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, + <span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>, + <span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, + <span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, + <span class="va">f_parent_saemix_dfop_tc_moreiter</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></code></pre></div> +<pre><code>Likelihoods calculated by importance sampling</code></pre> +<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">AIC_parent_saemix</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span> + <span class="st">"SFO const"</span>, <span class="st">"SFO tc"</span>, <span class="st">"DFOP const"</span>, <span class="st">"DFOP tc"</span>, <span class="st">"DFOP tc more iterations"</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix</span><span class="op">)</span></code></pre></div> +<pre><code> AIC BIC +SFO const 796.38 795.34 +SFO tc 798.38 797.13 +DFOP const 705.75 703.88 +DFOP tc 665.65 663.57 +DFOP tc more iterations 665.88 663.80</code></pre> +<p>In order to check the influence of the likelihood calculation algorithms implemented in saemix, the likelihood from Gaussian quadrature is added to the best fit, and the AIC values obtained from the three methods are compared.</p> +<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span> <span class="op"><-</span> + <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/llgq.saemix.html" class="external-link">llgq.saemix</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span> +<span class="va">AIC_parent_saemix_methods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span> + is <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"is"</span><span class="op">)</span>, + gq <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"gq"</span><span class="op">)</span>, + lin <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"lin"</span><span class="op">)</span> +<span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix_methods</span><span class="op">)</span></code></pre></div> +<pre><code> is gq lin +665.65 665.68 665.11 </code></pre> +<p>The AIC values based on importance sampling and Gaussian quadrature are very similar. Using linearisation is known to be less accurate, but still gives a similar value. In order to illustrate that the comparison of the three method depends on the degree of convergence obtained in the fit, the same comparison is shown below for the fit using the defaults for the number of iterations and the number of MCMC chains.</p> +<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_saemix_dfop_tc_defaults</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span> +<span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span> <span class="op"><-</span> + <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/llgq.saemix.html" class="external-link">llgq.saemix</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span><span class="op">)</span> +<span class="va">AIC_parent_saemix_methods_defaults</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span> + is <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"is"</span><span class="op">)</span>, + gq <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"gq"</span><span class="op">)</span>, + lin <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"lin"</span><span class="op">)</span> +<span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix_methods_defaults</span><span class="op">)</span></code></pre></div> +<pre><code> is gq lin +668.27 718.36 666.49 </code></pre> +</div> +<div class="section level4"> +<h4 id="nlmixr">nlmixr<a class="anchor" aria-label="anchor" href="#nlmixr"></a> +</h4> +<p>In the last years, a lot of effort has been put into the nlmixr package which is designed for pharmacokinetics, where nonlinear mixed-effects models are routinely used, but which can also be used for related data like chemical degradation data. A current development branch of the mkin package provides an interface between mkin and nlmixr. Here, we check if we get equivalent results when using a refined version of the First Order Conditional Estimation (FOCE) algorithm used in nlme, namely the First Order Conditional Estimation with Interaction (FOCEI), and the SAEM algorithm as implemented in nlmixr.</p> +<p>First, the focei algorithm is used for the four model combinations.</p> +<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/nlmixrdevelopment/nlmixr" class="external-link">nlmixr</a></span><span class="op">)</span> +<span class="va">f_parent_nlmixr_focei_sfo_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span> +<span class="va">f_parent_nlmixr_focei_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span> +<span class="va">f_parent_nlmixr_focei_dfop_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span> +<span class="va">f_parent_nlmixr_focei_dfop_tc</span><span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></code></pre></div> +<p>For the SFO model with constant variance, the AIC values are the same, for the DFOP model, there are significant differences between the AIC values. These may be caused by different solutions that are found, but also by the fact that the AIC values for the nlmixr fits are calculated based on Gaussian quadrature, not on linearisation.</p> +<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">aic_nlmixr_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span> + <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_focei_sfo_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_focei_sfo_tc</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_focei_dfop_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_focei_dfop_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span>, + <span class="va">AIC</span><span class="op">)</span> +<span class="va">aic_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span> + <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_const</span>, <span class="cn">NA</span>, <span class="va">f_parent_nlme_sfo_tc</span>, <span class="va">f_parent_nlme_dfop_tc</span><span class="op">)</span>, + <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/NA.html" class="external-link">is.na</a></span><span class="op">(</span><span class="va">x</span><span class="op">[</span><span class="fl">1</span><span class="op">]</span><span class="op">)</span><span class="op">)</span> <span class="cn">NA</span> <span class="kw">else</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">x</span><span class="op">)</span><span class="op">)</span> +<span class="va">aic_nlme_nlmixr_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + <span class="st">"Degradation model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"SFO"</span>, <span class="st">"DFOP"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, + <span class="st">"Error model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"constant variance"</span>, <span class="st">"two-component"</span><span class="op">)</span>, <span class="fl">2</span><span class="op">)</span>, + <span class="st">"AIC (nlme)"</span> <span class="op">=</span> <span class="va">aic_nlme</span>, + <span class="st">"AIC (nlmixr with FOCEI)"</span> <span class="op">=</span> <span class="va">aic_nlmixr_focei</span>, + check.names <span class="op">=</span> <span class="cn">FALSE</span> +<span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">aic_nlme_nlmixr_focei</span><span class="op">)</span></code></pre></div> +<pre><code> Degradation model Error model AIC (nlme) AIC (nlmixr with FOCEI) +1 SFO constant variance 796.60 796.60 +2 SFO two-component NA 798.64 +3 DFOP constant variance 798.60 745.87 +4 DFOP two-component 671.91 740.42</code></pre> +<p>Secondly, we use the SAEM estimation routine and check the convergence plots. The control parameters, which were also used for the saemix fits, are defined beforehand.</p> +<div class="sourceCode" id="cb30"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">nlmixr_saem_control_800</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>logLik <span class="op">=</span> <span class="cn">TRUE</span>, + nBurn <span class="op">=</span> <span class="fl">800</span>, nEm <span class="op">=</span> <span class="fl">300</span>, nmc <span class="op">=</span> <span class="fl">15</span><span class="op">)</span> +<span class="va">nlmixr_saem_control_moreiter</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>logLik <span class="op">=</span> <span class="cn">TRUE</span>, + nBurn <span class="op">=</span> <span class="fl">1600</span>, nEm <span class="op">=</span> <span class="fl">300</span>, nmc <span class="op">=</span> <span class="fl">15</span><span class="op">)</span> +<span class="va">nlmixr_saem_control_10k</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>logLik <span class="op">=</span> <span class="cn">TRUE</span>, + nBurn <span class="op">=</span> <span class="fl">10000</span>, nEm <span class="op">=</span> <span class="fl">1000</span>, nmc <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></code></pre></div> +<p>Then we fit SFO with constant variance</p> +<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_sfo_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_800</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_sfo_const</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_sfo_const-1.png" width="700"></p> +<p>and SFO with two-component error.</p> +<div class="sourceCode" id="cb32"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_800</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_sfo_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_sfo_tc-1.png" width="700"></p> +<p>For DFOP with constant variance, the convergence plots show considerable instability of the fit, which indicates overparameterisation which was already observed above for this model combination. Also note that the variance of k2 approximates zero, which was already observed in the saemix fits of the DFOP model.</p> +<div class="sourceCode" id="cb33"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_dfop_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_800</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_dfop_const</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_dfop_const-1.png" width="700"></p> +<p>For DFOP with two-component error, a less erratic convergence is seen, but the variance of k2 again approximates zero.</p> +<div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_800</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_dfop_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_dfop_tc-1.png" width="700"></p> +<p>To check if an increase in the number of iterations improves the fit, we repeat the fit with 1000 iterations for the burn in phase and 300 iterations for the second phase.</p> +<div class="sourceCode" id="cb35"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_dfop_tc_moreiter</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_moreiter</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_dfop_tc_moreiter</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_dfop_tc_1k-1.png" width="700"></p> +<p>Here the fit looks very similar, but we will see below that it shows a higher AIC than the fit with 800 iterations in the burn in phase. Next we choose 10 000 iterations for the burn in phase and 1000 iterations for the second phase for comparison with saemix.</p> +<div class="sourceCode" id="cb36"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">f_parent_nlmixr_saem_dfop_tc_10k</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>, + control <span class="op">=</span> <span class="va">nlmixr_saem_control_10k</span><span class="op">)</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/traceplot.html" class="external-link">traceplot</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_dfop_tc_10k</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<p><img src="dimethenamid_2018_files/figure-html/f_parent_nlmixr_saem_dfop_tc_10k-1.png" width="700"></p> +<p>The AIC values are internally calculated using Gaussian quadrature.</p> +<div class="sourceCode" id="cb37"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_sfo_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_saem_sfo_tc</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_saem_dfop_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_saem_dfop_tc</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_saem_dfop_tc_moreiter</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_saem_dfop_tc_10k</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></code></pre></div> +<pre><code> df AIC +f_parent_nlmixr_saem_sfo_const$nm 5 798.71 +f_parent_nlmixr_saem_sfo_tc$nm 6 808.64 +f_parent_nlmixr_saem_dfop_const$nm 9 1995.96 +f_parent_nlmixr_saem_dfop_tc$nm 10 664.96 +f_parent_nlmixr_saem_dfop_tc_moreiter$nm 10 4464.93 +f_parent_nlmixr_saem_dfop_tc_10k$nm 10 Inf</code></pre> +<p>We can see that again, the DFOP/tc model shows the best goodness of fit. However, increasing the number of burn-in iterations from 800 to 1600 results in a higher AIC. If we further increase the number of iterations to 10 000 (burn-in) and 1000 (second phase), the AIC cannot be calculated for the nlmixr/saem fit, confirming that this fit does not converge properly with the SAEM algorithm.</p> +</div> +<div class="section level4"> +<h4 id="comparison">Comparison<a class="anchor" aria-label="anchor" href="#comparison"></a> +</h4> +<p>The following table gives the AIC values obtained with the three packages using the same control parameters (800 iterations burn-in, 300 iterations second phase, 15 chains).</p> +<div class="sourceCode" id="cb39"><pre class="downlit sourceCode r"> +<code class="sourceCode R"><span class="va">AIC_all</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span> + check.names <span class="op">=</span> <span class="cn">FALSE</span>, + <span class="st">"Degradation model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"SFO"</span>, <span class="st">"DFOP"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, + <span class="st">"Error model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"const"</span>, <span class="st">"tc"</span>, <span class="st">"const"</span>, <span class="st">"tc"</span><span class="op">)</span>, + nlme <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_const</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_tc</span><span class="op">)</span>, <span class="cn">NA</span>, <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span><span class="op">)</span><span class="op">)</span>, + nlmixr_focei <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_focei_sfo_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_focei_sfo_tc</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_focei_dfop_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_focei_dfop_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span>, <span class="va">AIC</span><span class="op">)</span>, + saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>, + <span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span>, <span class="va">AIC</span><span class="op">)</span>, + nlmixr_saem <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_nlmixr_saem_sfo_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_saem_sfo_tc</span><span class="op">$</span><span class="va">nm</span>, + <span class="va">f_parent_nlmixr_saem_dfop_const</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_parent_nlmixr_saem_dfop_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span>, <span class="va">AIC</span><span class="op">)</span> +<span class="op">)</span> +<span class="fu">kable</span><span class="op">(</span><span class="va">AIC_all</span><span class="op">)</span></code></pre></div> +<table class="table"> +<thead><tr class="header"> +<th align="left">Degradation model</th> +<th align="left">Error model</th> +<th align="right">nlme</th> +<th align="right">nlmixr_focei</th> +<th align="right">saemix</th> +<th align="right">nlmixr_saem</th> +</tr></thead> +<tbody> +<tr class="odd"> +<td align="left">SFO</td> +<td align="left">const</td> +<td align="right">796.60</td> +<td align="right">796.60</td> +<td align="right">796.38</td> +<td align="right">798.71</td> +</tr> +<tr class="even"> +<td align="left">SFO</td> +<td align="left">tc</td> +<td align="right">798.60</td> +<td align="right">798.64</td> +<td align="right">798.38</td> +<td align="right">808.64</td> +</tr> +<tr class="odd"> +<td align="left">DFOP</td> +<td align="left">const</td> +<td align="right">NA</td> +<td align="right">745.87</td> +<td align="right">705.75</td> +<td align="right">1995.96</td> +</tr> +<tr class="even"> +<td align="left">DFOP</td> +<td align="left">tc</td> +<td align="right">671.91</td> +<td align="right">740.42</td> +<td align="right">665.65</td> +<td align="right">664.96</td> +</tr> +</tbody> +</table> +</div> +</div> +</div> +<div class="section level2"> +<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> +<!-- vim: set foldmethod=syntax: --> +<div id="refs" class="references hanging-indent"> +<div id="ref-efsa_2018_dimethenamid"> +<p>EFSA. 2018. “Peer Review of the Pesticide Risk Assessment of the Active Substance Dimethenamid-P.” <em>EFSA Journal</em> 16 (4): 5211.</p> +</div> +<div id="ref-ranke2021"> +<p>Ranke, Johannes, Janina Wöltjen, Jana Schmidt, and Emmanuelle Comets. 2021. “Taking Kinetic Evaluations of Degradation Data to the Next Level with Nonlinear Mixed-Effects Models.” <em>Environments</em> 8 (8). <a href="https://doi.org/10.3390/environments8080071" class="external-link">https://doi.org/10.3390/environments8080071</a>.</p> +</div> +<div id="ref-dimethenamid_rar_2018_b8"> +<p>Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria. 2018. “Renewal Assessment Report Dimethenamid-P Volume 3 - B.8 Environmental fate and behaviour, Rev. 2 - November 2017.” <a href="https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a>.</p> +</div> +</div> +</div> + </div> + + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + + <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> + </nav> +</div> + +</div> + + + + <footer><div class="copyright"> + <p></p> +<p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer> +</div> + + + + + + + </body> +</html> diff --git a/docs/articles/web_only/dimethenamid_2018_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/articles/web_only/dimethenamid_2018_files/accessible-code-block-0.0.1/empty-anchor.js new file mode 100644 index 00000000..ca349fd6 --- /dev/null +++ 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class="navbar-link" href="index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -86,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -97,6 +41,9 @@ <a href="articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -111,53 +58,66 @@ <li> <a href="articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="contents col-md-9"> - <div class="page-header"> - <h1>Authors</h1> + <div class="section level2 authors-section"> + <div class="page-header"> + <h1>Authors</h1> + </div> + + + <ul class="list-unstyled"><li> + <p><strong>Johannes Ranke</strong>. Author, maintainer, copyright holder. <a href="https://orcid.org/0000-0003-4371-6538" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> + </p> + </li> + <li> + <p><strong>Katrin Lindenberger</strong>. Contributor. + <br><small>contributed to mkinresplot()</small></p> + </li> + <li> + <p><strong>René Lehmann</strong>. Contributor. + <br><small>ilr() and invilr()</small></p> + </li> + <li> + <p><strong>Eurofins Regulatory AG</strong>. Copyright holder. + <br><small>copyright for some of the contributions of JR 2012-2014</small></p> + </li> + </ul></div> + <div class="section level2 citation-section"> + <div> + <h1 id="citation">Citation</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/DESCRIPTION" class="external-link"><code>DESCRIPTION</code></a></small> + </div> </div> - <ul class="list-unstyled"> - <li> - <p><strong>Johannes Ranke</strong>. Author, maintainer, copyright holder. <a href='https://orcid.org/0000-0003-4371-6538' target='orcid.widget' aria-label='ORCID'><span class='fab fa-orcid orcid' aria-hidden='true'></span></a> - </p> - </li> - <li> - <p><strong>Katrin Lindenberger</strong>. Contributor. - <br /><small>contributed to mkinresplot()</small></p> - </li> - <li> - <p><strong>René Lehmann</strong>. Contributor. - <br /><small>ilr() and invilr()</small></p> - </li> - <li> - <p><strong>Eurofins Regulatory AG</strong>. Copyright holder. - <br /><small>copyright for some of the contributions of JR 2012-2014</small></p> - </li> - </ul> + + <p>Ranke J (2022). +<em>mkin: Kinetic Evaluation of Chemical Degradation Data</em>. +R package version 1.1.0, <a href="https://pkgdown.jrwb.de/mkin/">https://pkgdown.jrwb.de/mkin/</a>. +</p> + <pre>@Manual{, + title = {mkin: Kinetic Evaluation of Chemical Degradation Data}, + author = {Johannes Ranke}, + year = {2022}, + note = {R package version 1.1.0}, + url = {https://pkgdown.jrwb.de/mkin/}, +}</pre> </div> @@ -165,22 +125,20 @@ - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/index.html b/docs/index.html index 59d4f596..df842cce 100644 --- a/docs/index.html +++ b/docs/index.html @@ -16,15 +16,22 @@ 2014). Includes a function for conveniently defining differential equation models, model solution based on eigenvalues if possible or using numerical solvers. If a C compiler (on windows: Rtools) is installed, differential - equation models are solved using automatically generated C functions. Please - note that no warranty is implied for correctness of results or fitness for a - particular purpose."> + equation models are solved using automatically generated C functions. + Heteroscedasticity can be taken into account using variance by variable or + two-component error models as described by Ranke and Meinecke (2018) + <doi:10.3390/environments6120124>. Interfaces to several nonlinear + mixed-effects model packages are available, some of which are described by + Ranke et al. (2021) <doi:10.3390/environments8080071>. Please note that no + warranty is implied for correctness of results or fitness for a particular + purpose."> <!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> <![endif]--> </head> <body data-spy="scroll" data-target="#toc"> + + <div class="container template-home"> <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> @@ -37,7 +44,7 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> @@ -63,6 +70,9 @@ <a href="articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -85,7 +95,7 @@ </ul> <ul class="nav navbar-nav navbar-right"> <li> - <a href="https://github.com/jranke/mkin/"> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> @@ -102,39 +112,39 @@ </header><div class="row"> <div class="contents col-md-9"> -<div id="mkin" class="section level1"> -<div class="page-header"><h1 class="hasAnchor"> -<a href="#mkin" class="anchor"></a>mkin</h1></div> +<div class="section level1"> +<div class="page-header"><h1 id="mkin">mkin<a class="anchor" aria-label="anchor" href="#mkin"></a> +</h1></div> <p>The R package <strong>mkin</strong> provides calculation routines for the analysis of chemical degradation data, including <b>m</b>ulticompartment <b>kin</b>etics as needed for modelling the formation and decline of transformation products, or if several degradation compartments are involved.</p> -<div id="installation" class="section level2"> -<h2 class="hasAnchor"> -<a href="#installation" class="anchor"></a>Installation</h2> -<p>You can install the latest released version from <a href="https://cran.r-project.org/package=mkin">CRAN</a> from within R:</p> +<div class="section level2"> +<h2 id="installation">Installation<a class="anchor" aria-label="anchor" href="#installation"></a> +</h2> +<p>You can install the latest released version from <a href="https://cran.r-project.org/package=mkin" class="external-link">CRAN</a> from within R:</p> <div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/utils/install.packages.html">install.packages</a></span><span class="op">(</span><span class="st">"mkin"</span><span class="op">)</span></code></pre></div> +<code class="sourceCode R"><span class="fu"><a href="https://rdrr.io/r/utils/install.packages.html" class="external-link">install.packages</a></span><span class="op">(</span><span class="st">"mkin"</span><span class="op">)</span></code></pre></div> </div> -<div id="background" class="section level2"> -<h2 class="hasAnchor"> -<a href="#background" class="anchor"></a>Background</h2> +<div class="section level2"> +<h2 id="background">Background<a class="anchor" aria-label="anchor" href="#background"></a> +</h2> <p>In the regulatory evaluation of chemical substances like plant protection products (pesticides), biocides and other chemicals, degradation data play an important role. For the evaluation of pesticide degradation experiments, detailed guidance and helpful tools have been developed as detailed in ‘Credits and historical remarks’ below.</p> </div> -<div id="usage" class="section level2"> -<h2 class="hasAnchor"> -<a href="#usage" class="anchor"></a>Usage</h2> +<div class="section level2"> +<h2 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a> +</h2> <p>For a start, have a look at the code examples provided for <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mkinfit.html"><code>plot.mkinfit</code></a> and <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mmkin.html"><code>plot.mmkin</code></a>, and at the package vignettes <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_L.html"><code>FOCUS L</code></a> and <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_D.html"><code>FOCUS D</code></a>.</p> </div> -<div id="documentation" class="section level2"> -<h2 class="hasAnchor"> -<a href="#documentation" class="anchor"></a>Documentation</h2> -<p>The HTML documentation of the latest version released to CRAN is available at <a href="https://pkgdown.jrwb.de/mkin/">jrwb.de</a> and <a href="https://jranke.github.io/mkin/">github</a>. Documentation of the development version is found in the <a href="https://pkgdown.jrwb.de/mkin/dev/">‘dev’ subdirectory</a>.</p> +<div class="section level2"> +<h2 id="documentation">Documentation<a class="anchor" aria-label="anchor" href="#documentation"></a> +</h2> +<p>The HTML documentation of the latest version released to CRAN is available at <a href="https://pkgdown.jrwb.de/mkin/">jrwb.de</a> and <a href="https://jranke.github.io/mkin/" class="external-link">github</a>. Documentation of the development version is found in the <a href="https://pkgdown.jrwb.de/mkin/dev/">‘dev’ subdirectory</a>.</p> </div> -<div id="features" class="section level2"> -<h2 class="hasAnchor"> -<a href="#features" class="anchor"></a>Features</h2> -<div id="general" class="section level3"> -<h3 class="hasAnchor"> -<a href="#general" class="anchor"></a>General</h3> +<div class="section level2"> +<h2 id="features">Features<a class="anchor" aria-label="anchor" href="#features"></a> +</h2> +<div class="section level3"> +<h3 id="general">General<a class="anchor" aria-label="anchor" href="#general"></a> +</h3> <ul> <li>Highly flexible model specification using <a href="https://pkgdown.jrwb.de/mkin/reference/mkinmod.html"><code>mkinmod</code></a>, including equilibrium reactions and using the single first-order reversible binding (SFORB) model, which will automatically create two latent state variables for the observed variable.</li> <li>Model solution (forward modelling) in the function <a href="https://pkgdown.jrwb.de/mkin/reference/mkinpredict.html"><code>mkinpredict</code></a> is performed either using the analytical solution for the case of parent only degradation, an eigenvalue based solution if only simple first-order (SFO) or SFORB kinetics are used in the model, or using a numeric solver from the <code>deSolve</code> package (default is <code>lsoda</code>).</li> @@ -144,9 +154,9 @@ <li>The ‘variance by variable’ error model which is often fitted using Iteratively Reweighted Least Squares (IRLS) should now be specified as <code>error_model = "obs"</code>.</li> </ul> </div> -<div id="unique-in-mkin" class="section level3"> -<h3 class="hasAnchor"> -<a href="#unique-in-mkin" class="anchor"></a>Unique in mkin</h3> +<div class="section level3"> +<h3 id="unique-in-mkin">Unique in mkin<a class="anchor" aria-label="anchor" href="#unique-in-mkin"></a> +</h3> <ul> <li>Three different error models can be selected using the argument <code>error_model</code> to the <a href="https://pkgdown.jrwb.de/mkin/reference/mkinfit.html"><code>mkinfit</code></a> function. A two-component error model similar to the one proposed by <a href="https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html">Rocke and Lorenzato</a> can be selected using the argument <code>error_model = "tc"</code>.</li> <li>Model comparisons using the Akaike Information Criterion (AIC) are supported which can also be used for non-constant variance. In such cases the FOCUS chi-squared error level is not meaningful.</li> @@ -156,37 +166,37 @@ <li>Nonlinear mixed-effects models can be created from fits of the same degradation model to different datasets for the same compound by using the <a href="https://pkgdown.jrwb.de/mkin/reference/nlme.mmkin.html">nlme.mmkin</a> method. Note that the convergence of the nlme fits depends on the quality of the data. Convergence is better for simple models and data for many groups (e.g. soils).</li> </ul> </div> -<div id="performance" class="section level3"> -<h3 class="hasAnchor"> -<a href="#performance" class="anchor"></a>Performance</h3> +<div class="section level3"> +<h3 id="performance">Performance<a class="anchor" aria-label="anchor" href="#performance"></a> +</h3> <ul> <li>Parallel fitting of several models to several datasets is supported, see for example <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mmkin.html"><code>plot.mmkin</code></a>.</li> -<li>If a C compiler is installed, the kinetic models are compiled from automatically generated C code, see <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">vignette <code>compiled_models</code></a>. The autogeneration of C code was inspired by the <a href="https://github.com/karlines/ccSolve"><code>ccSolve</code></a> package. Thanks to Karline Soetaert for her work on that.</li> -<li>Even if no compiler is installed, many degradation models still give <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/benchmarks.html">very good performance</a>, as current versions of mkin also have <a href="https://jrwb.de/performance-improvements-mkin/">analytical solutions for some models with one metabolite</a>, and if SFO or SFORB are used for the parent compound, Eigenvalue based solutions of the degradation model are available.</li> +<li>If a C compiler is installed, the kinetic models are compiled from automatically generated C code, see <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">vignette <code>compiled_models</code></a>. The autogeneration of C code was inspired by the <a href="https://github.com/karlines/ccSolve" class="external-link"><code>ccSolve</code></a> package. Thanks to Karline Soetaert for her work on that.</li> +<li>Even if no compiler is installed, many degradation models still give <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/benchmarks.html">very good performance</a>, as current versions of mkin also have <a href="https://jrwb.de/performance-improvements-mkin/" class="external-link">analytical solutions for some models with one metabolite</a>, and if SFO or SFORB are used for the parent compound, Eigenvalue based solutions of the degradation model are available.</li> </ul> </div> </div> -<div id="gui" class="section level2"> -<h2 class="hasAnchor"> -<a href="#gui" class="anchor"></a>GUI</h2> -<p>There is a graphical user interface that may be useful. Please refer to its <a href="https://pkgdown.jrwb.de/gmkin/">documentation page</a> for installation instructions and a manual.</p> +<div class="section level2"> +<h2 id="gui">GUI<a class="anchor" aria-label="anchor" href="#gui"></a> +</h2> +<p>There is a graphical user interface that may be useful. Please refer to its <a href="https://pkgdown.jrwb.de/gmkin/" class="external-link">documentation page</a> for installation instructions and a manual.</p> </div> -<div id="news" class="section level2"> -<h2 class="hasAnchor"> -<a href="#news" class="anchor"></a>News</h2> -<p>There is a list of changes for the latest <a href="https://cran.r-project.org/package=mkin/news/news.html">CRAN release</a> and one for each github branch, e.g. <a href="https://github.com/jranke/mkin/blob/master/NEWS.md">the main branch</a>.</p> +<div class="section level2"> +<h2 id="news">News<a class="anchor" aria-label="anchor" href="#news"></a> +</h2> +<p>There is a list of changes for the latest <a href="https://cran.r-project.org/package=mkin/news/news.html" class="external-link">CRAN release</a> and one for each github branch, e.g. <a href="https://github.com/jranke/mkin/blob/main/NEWS.md" class="external-link">the main branch</a>.</p> </div> -<div id="credits-and-historical-remarks" class="section level2"> -<h2 class="hasAnchor"> -<a href="#credits-and-historical-remarks" class="anchor"></a>Credits and historical remarks</h2> -<p><code>mkin</code> would not be possible without the underlying software stack consisting of, among others, R and the package <a href="https://cran.r-project.org/package=deSolve">deSolve</a>. In previous version, <code>mkin</code> was also using the functionality of the <a href="https://cran.r-project.org/package=FME">FME</a> package. Please refer to the <a href="https://cran.r-project.org/package=mkin">package page on CRAN</a> for the full list of imported and suggested R packages. Also, <a href="https://debian.org">Debian Linux</a>, the vim editor and the <a href="https://github.com/jalvesaq/Nvim-R">Nvim-R</a> plugin have been invaluable in its development.</p> -<p><code>mkin</code> could not have been written without me being introduced to regulatory fate modelling of pesticides by Adrian Gurney during my time at Harlan Laboratories Ltd (formerly RCC Ltd). <code>mkin</code> greatly profits from and largely follows the work done by the <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics">FOCUS Degradation Kinetics Workgroup</a>, as detailed in their guidance document from 2006, slightly updated in 2011 and in 2014.</p> +<div class="section level2"> +<h2 id="credits-and-historical-remarks">Credits and historical remarks<a class="anchor" aria-label="anchor" href="#credits-and-historical-remarks"></a> +</h2> +<p><code>mkin</code> would not be possible without the underlying software stack consisting of, among others, R and the package <a href="https://cran.r-project.org/package=deSolve" class="external-link">deSolve</a>. In previous version, <code>mkin</code> was also using the functionality of the <a href="https://cran.r-project.org/package=FME" class="external-link">FME</a> package. Please refer to the <a href="https://cran.r-project.org/package=mkin" class="external-link">package page on CRAN</a> for the full list of imported and suggested R packages. Also, <a href="https://debian.org" class="external-link">Debian Linux</a>, the vim editor and the <a href="https://github.com/jalvesaq/Nvim-R" class="external-link">Nvim-R</a> plugin have been invaluable in its development.</p> +<p><code>mkin</code> could not have been written without me being introduced to regulatory fate modelling of pesticides by Adrian Gurney during my time at Harlan Laboratories Ltd (formerly RCC Ltd). <code>mkin</code> greatly profits from and largely follows the work done by the <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">FOCUS Degradation Kinetics Workgroup</a>, as detailed in their guidance document from 2006, slightly updated in 2011 and in 2014.</p> <p>Also, it was inspired by the first version of KinGUI developed by BayerCropScience, which is based on the MatLab runtime environment.</p> -<p>The companion package <a href="http://kinfit.r-forge.r-project.org/kinfit_static/index.html">kinfit</a> (now deprecated) was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=2">started in 2008</a> and <a href="https://cran.r-project.org/src/contrib/Archive/kinfit/">first published</a> on CRAN on 01 May 2010.</p> -<p>The first <code>mkin</code> code was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=8">published on 11 May 2010</a> and the <a href="https://cran.r-project.org/src/contrib/Archive/mkin/">first CRAN version</a> on 18 May 2010.</p> +<p>The companion package <a href="http://kinfit.r-forge.r-project.org/kinfit_static/index.html" class="external-link">kinfit</a> (now deprecated) was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=2" class="external-link">started in 2008</a> and <a href="https://cran.r-project.org/src/contrib/Archive/kinfit/" class="external-link">first published</a> on CRAN on 01 May 2010.</p> +<p>The first <code>mkin</code> code was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=8" class="external-link">published on 11 May 2010</a> and the <a href="https://cran.r-project.org/src/contrib/Archive/mkin/" class="external-link">first CRAN version</a> on 18 May 2010.</p> <p>In 2011, Bayer Crop Science started to distribute an R based successor to KinGUI named KinGUII whose R code is based on <code>mkin</code>, but which added, among other refinements, a closed source graphical user interface (GUI), iteratively reweighted least squares (IRLS) optimisation of the variance for each of the observed variables, and Markov Chain Monte Carlo (MCMC) simulation functionality, similar to what is available e.g. in the <code>FME</code> package.</p> -<p>Somewhat in parallel, Syngenta has sponsored the development of an <code>mkin</code> and KinGUII based GUI application called CAKE, which also adds IRLS and MCMC, is more limited in the model formulation, but puts more weight on usability. CAKE is available for download from the <a href="https://www.tessella.com/showcase/computer-assisted-kinetic-evaluation">CAKE website</a>, where you can also find a zip archive of the R scripts derived from <code>mkin</code>, published under the GPL license.</p> -<p>Finally, there is <a href="https://github.com/zhenglei-gao/KineticEval">KineticEval</a>, which contains a further development of the scripts used for KinGUII, so the different tools will hopefully be able to learn from each other in the future as well.</p> +<p>Somewhat in parallel, Syngenta has sponsored the development of an <code>mkin</code> and KinGUII based GUI application called CAKE, which also adds IRLS and MCMC, is more limited in the model formulation, but puts more weight on usability. CAKE is available for download from the <a href="https://cake-kinetics.org" class="external-link">CAKE website</a>, where you can also find a zip archive of the R scripts derived from <code>mkin</code>, published under the GPL license.</p> +<p>Finally, there is <a href="https://github.com/zhenglei-gao/KineticEval" class="external-link">KineticEval</a>, which contains a further development of the scripts used for KinGUII, so the different tools will hopefully be able to learn from each other in the future as well.</p> <p>Thanks to René Lehmann, formerly working at the Umweltbundesamt, for the nice cooperation cooperation on parameter transformations, especially the isometric log-ratio transformation that is now used for formation fractions in case there are more than two transformation targets.</p> <p>Many inspirations for improvements of mkin resulted from doing kinetic evaluations of degradation data for my clients while working at Harlan Laboratories and at Eurofins Regulatory AG, and now as an independent consultant.</p> <p>Funding was received from the Umweltbundesamt in the course of the projects</p> @@ -199,30 +209,30 @@ <li>Project Number 146839 (Checking the feasibility of using mixed-effects models for the derivation of kinetic modelling parameters from degradation studies, 2020-2021)</li> </ul> </div> -<div id="references" class="section level2"> -<h2 class="hasAnchor"> -<a href="#references" class="anchor"></a>References</h2> +<div class="section level2"> +<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> +</h2> <table class="table"> <tr> <td> -Ranke J, Wöltjen J, Schmidt J, and Comets E (2021) Taking kinetic evaluations of degradation data to the next level with nonlinear mixed-effects models. <i>Environments</i> <b>8</b> (8) 71 <a href="https://doi.org/10.3390/environments8080071">doi:10.3390/environments8080071</a> +Ranke J, Wöltjen J, Schmidt J, and Comets E (2021) Taking kinetic evaluations of degradation data to the next level with nonlinear mixed-effects models. <i>Environments</i> <b>8</b> (8) 71 <a href="https://doi.org/10.3390/environments8080071" class="external-link">doi:10.3390/environments8080071</a> </td> </tr> <tr> <td> -Ranke J, Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical Degradation Data <i>Environments</i> <b>6</b> (12) 124 <a href="https://doi.org/10.3390/environments6120124">doi:10.3390/environments6120124</a> +Ranke J, Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical Degradation Data <i>Environments</i> <b>6</b> (12) 124 <a href="https://doi.org/10.3390/environments6120124" class="external-link">doi:10.3390/environments6120124</a> </td> </tr> <tr> <td> -Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic evaluation of chemical degradation data <i>Environmental Sciences Europe</i> <b>30</b> 17 <a href="https://doi.org/10.1186/s12302-018-0145-1">doi:10.1186/s12302-018-0145-1</a> +Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic evaluation of chemical degradation data <i>Environmental Sciences Europe</i> <b>30</b> 17 <a href="https://doi.org/10.1186/s12302-018-0145-1" class="external-link">doi:10.1186/s12302-018-0145-1</a> </td> </tr> </table> </div> -<div id="development" class="section level2"> -<h2 class="hasAnchor"> -<a href="#development" class="anchor"></a>Development</h2> +<div class="section level2"> +<h2 id="development">Development<a class="anchor" aria-label="anchor" href="#development"></a> +</h2> <p>Contributions are welcome!</p> </div> </div> @@ -230,48 +240,58 @@ Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> <div class="links"> -<h2>Links</h2> +<h2 data-toc-skip>Links</h2> <ul class="list-unstyled"> -<li>Download from CRAN at <br><a href="https://cloud.r-project.org/package=mkin">https://cloud.r-project.org/package=mkin</a> -</li> -<li>Browse source code at <br><a href="https://github.com/jranke/mkin/">https://github.com/jranke/mkin/</a> -</li> -<li>Report a bug at <br><a href="https://github.com/jranke/mkin/issues/">https://github.com/jranke/mkin/issues/</a> -</li> +<li><a href="https://cloud.r-project.org/package=mkin" class="external-link">View on CRAN</a></li> +<li><a href="https://github.com/jranke/mkin/" class="external-link">Browse source code</a></li> +<li><a href="https://github.com/jranke/mkin/issues/" class="external-link">Report a bug</a></li> </ul> </div> + <div class="license"> -<h2>License</h2> +<h2 data-toc-skip>License</h2> <ul class="list-unstyled"> <li>GPL</li> </ul> </div> -<div class="developers"> -<h2>Developers</h2> + + +<div class="citation"> +<h2 data-toc-skip>Citation</h2> <ul class="list-unstyled"> -<li>Johannes Ranke <br><small class="roles"> Author, maintainer, copyright holder </small> <a href="https://orcid.org/0000-0003-4371-6538" target="orcid.widget" aria-label="ORCID"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li> -<li><a href="authors.html">All authors...</a></li> +<li><a href="authors.html#citation">Citing mkin</a></li> </ul> </div> - <div class="dev-status"> -<h2>Dev status</h2> +<div class="developers"> +<h2 data-toc-skip>Developers</h2> <ul class="list-unstyled"> -<li><a href="https://cran.r-project.org/package=mkin"><img src="https://www.r-pkg.org/badges/version/mkin"></a></li> -<li><a href="https://app.travis-ci.com/github/jranke/mkin"><img src="https://travis-ci.com/jranke/mkin.svg?branch=master" alt="Build Status"></a></li> -<li><a href="https://codecov.io/github/jranke/mkin"><img src="https://codecov.io/github/jranke/mkin/branch/master/graphs/badge.svg" alt="codecov"></a></li> +<li>Johannes Ranke <br><small class="roles"> Author, maintainer, copyright holder </small> <a href="https://orcid.org/0000-0003-4371-6538" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li> +<li><a href="authors.html">More about authors...</a></li> </ul> </div> + +<div class="dev-status"> +<h2 data-toc-skip>Dev status</h2> +<ul class="list-unstyled"> +<li><a href="https://cran.r-project.org/package=mkin" class="external-link"><img src="https://www.r-pkg.org/badges/version/mkin"></a></li> +<li><a href="https://app.travis-ci.com/github/jranke/mkin" class="external-link"><img src="https://travis-ci.com/jranke/mkin.svg?branch=main" alt="Build Status"></a></li> +<li><a href="https://codecov.io/github/jranke/mkin" class="external-link"><img src="https://codecov.io/github/jranke/mkin/branch/main/graphs/badge.svg" alt="codecov"></a></li> +</ul> </div> + + </div> </div> <footer><div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <p></p> +<p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p> +<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> </footer> @@ -280,5 +300,7 @@ Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic + + </body> </html> diff --git a/docs/news/index.html b/docs/news/index.html index 75b701d2..0a73f051 100644 --- a/docs/news/index.html +++ b/docs/news/index.html @@ -1,66 +1,12 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Changelog • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" 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-<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-news"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -71,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -86,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -97,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -111,85 +58,72 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1 data-toc-skip>Changelog <small></small></h1> - <small>Source: <a href='https://github.com/jranke/mkin/blob/master/NEWS.md'><code>NEWS.md</code></a></small> + <small>Source: <a href="https://github.com/jranke/mkin/blob/HEAD/NEWS.md" class="external-link"><code>NEWS.md</code></a></small> </div> - <div id="mkin-105-2021-09-15" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.5"> -<a href="#mkin-105-2021-09-15" class="anchor"></a>mkin 1.0.5 (2021-09-15)</h1> -<ul> -<li>‘dimethenamid_2018’: Correct the data for the Borstel soil. The five observations from Staudenmaier (2013) that were previously stored as “Borstel 2” are actually just a subset of the 16 observations in “Borstel 1” which is now simply “Borstel”</li> -</ul> -</div> - <div id="mkin-104-2021-04-20" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.4"> -<a href="#mkin-104-2021-04-20" class="anchor"></a>mkin 1.0.4 (2021-04-20)</h1> -<ul> -<li><p>All plotting functions setting graphical parameters: Use on.exit() for resetting graphical parameters</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.1.0" id="mkin-110-unreleased">mkin 1.1.0 (unreleased)<a class="anchor" aria-label="anchor" href="#mkin-110-unreleased"></a></h2> +<div class="section level3"> +<h3 id="mixed-effects-models-1-1-0">Mixed-effects models<a class="anchor" aria-label="anchor" href="#mixed-effects-models-1-1-0"></a></h3> +<ul><li><p>Introduce an interface to nlmixr, supporting estimation methods ‘saem’ and ‘focei’: S3 method ‘nlmixr.mmkin’ using the helper functions ‘nlmixr_model’ and ‘nlmixr_data’ to set up nlmixr models for mmkin row objects, with summary and plot methods.</p></li> +<li><p>Reintroduce the interface to saemix (now on CRAN), in particular the generic function ‘saem’ with a generator ‘saem.mmkin’, currently using ‘saemix_model’ and ‘saemix_data’, summary and plot methods</p></li> +<li><p>‘mean_degparms’: New argument ‘test_log_parms’ that makes the function only consider log-transformed parameters where the untransformed parameters pass the t-test for a certain confidence level. This can be used to obtain more plausible starting parameters for the different mixed-effects model backends</p></li> +<li><p>‘plot.mixed.mmkin’: Gains arguments ‘test_log_parms’ and ‘conf.level’</p></li> +<li><p>‘vignettes/web_only/dimethenamid_2018.rmd’: Example evaluations of the dimethenamid data.</p></li> +<li><p>‘intervals’: Provide methods of this nlme function for ‘nlmixr.mmkin’ and ‘saem.mmkin’ objects.</p></li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.5" id="mkin-105-2021-09-15">mkin 1.0.5 (2021-09-15)<a class="anchor" aria-label="anchor" href="#mkin-105-2021-09-15"></a></h2> +<ul><li>‘dimethenamid_2018’: Correct the data for the Borstel soil. The five observations from Staudenmaier (2013) that were previously stored as “Borstel 2” are actually just a subset of the 16 observations in “Borstel 1” which is now simply “Borstel”</li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.4" id="mkin-104-2021-04-20">mkin 1.0.4 (2021-04-20)<a class="anchor" aria-label="anchor" href="#mkin-104-2021-04-20"></a></h2> +<ul><li><p>All plotting functions setting graphical parameters: Use on.exit() for resetting graphical parameters</p></li> <li><p>‘plot.mkinfit’: Use xlab and xlim for the residual plot if show_residuals is TRUE</p></li> <li><p>‘mmkin’: Use cores = 1 per default on Windows to make it easier for first time users</p></li> -</ul> -</div> - <div id="mkin-103-2021-02-15" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.3"> -<a href="#mkin-103-2021-02-15" class="anchor"></a>mkin 1.0.3 (2021-02-15)</h1> -<ul> -<li>Review and update README, the ‘Introduction to mkin’ vignette and some of the help pages</li> -</ul> -</div> - <div id="mkin-102-unreleased" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.2"> -<a href="#mkin-102-unreleased" class="anchor"></a>mkin 1.0.2 (Unreleased)</h1> -<ul> -<li>‘mkinfit’: Keep model names stored in ‘mkinmod’ objects, avoiding their loss in ‘gmkin’</li> -</ul> -</div> - <div id="mkin-101-2021-02-10" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.1"> -<a href="#mkin-101-2021-02-10" class="anchor"></a>mkin 1.0.1 (2021-02-10)</h1> -<ul> -<li><p>‘confint.mmkin’, ‘nlme.mmkin’, ‘transform_odeparms’: Fix example code in dontrun sections that failed with current defaults</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.3" id="mkin-103-2021-02-15">mkin 1.0.3 (2021-02-15)<a class="anchor" aria-label="anchor" href="#mkin-103-2021-02-15"></a></h2> +<ul><li>Review and update README, the ‘Introduction to mkin’ vignette and some of the help pages</li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.2" id="mkin-102-unreleased">mkin 1.0.2 (Unreleased)<a class="anchor" aria-label="anchor" href="#mkin-102-unreleased"></a></h2> +<ul><li>‘mkinfit’: Keep model names stored in ‘mkinmod’ objects, avoiding their loss in ‘gmkin’</li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.1" id="mkin-101-2021-02-10">mkin 1.0.1 (2021-02-10)<a class="anchor" aria-label="anchor" href="#mkin-101-2021-02-10"></a></h2> +<ul><li><p>‘confint.mmkin’, ‘nlme.mmkin’, ‘transform_odeparms’: Fix example code in dontrun sections that failed with current defaults</p></li> <li><p>‘logLik.mkinfit’: Improve example code to avoid warnings and show convenient syntax</p></li> <li><p>‘mkinresplot’: Re-add Katrin Lindenberger as coauthor who was accidentally removed long ago</p></li> <li><p>Remove tests relying on non-convergence of the FOMC fit to the FOCUS A dataset as this is platform dependent (revealed by the new additional tests on CRAN, thanks!)</p></li> <li><p>Increase test tolerance for some parameter comparisons that also proved to be platform dependent</p></li> -</ul> -</div> - <div id="mkin-100-2021-02-03" class="section level1"> -<h1 class="page-header" data-toc-text="1.0.0"> -<a href="#mkin-100-2021-02-03" class="anchor"></a>mkin 1.0.0 (2021-02-03)</h1> -<div id="general" class="section level2"> -<h2 class="hasAnchor"> -<a href="#general" class="anchor"></a>General</h2> -<ul> -<li><p>‘mkinmod’ models gain arguments ‘name’ and ‘dll_dir’ which, in conjunction with a current version of the ‘inline’ package, make it possible to still use the DLL used for fast ODE solutions with ‘deSolve’ after saving and restoring the ‘mkinmod’ object.</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="1.0.0" id="mkin-100-2021-02-03">mkin 1.0.0 (2021-02-03)<a class="anchor" aria-label="anchor" href="#mkin-100-2021-02-03"></a></h2> +<div class="section level3"> +<h3 id="general-1-0-0">General<a class="anchor" aria-label="anchor" href="#general-1-0-0"></a></h3> +<ul><li><p>‘mkinmod’ models gain arguments ‘name’ and ‘dll_dir’ which, in conjunction with a current version of the ‘inline’ package, make it possible to still use the DLL used for fast ODE solutions with ‘deSolve’ after saving and restoring the ‘mkinmod’ object.</p></li> <li><p>‘mkindsg’ R6 class for groups of ‘mkinds’ datasets with metadata</p></li> <li><p>‘f_norm_temp_focus’ generic function to normalise time intervals using the FOCUS method, with methods for numeric vectors and ‘mkindsg’ objects</p></li> <li><p>‘D24_2014’ and ‘dimethenamid_2018’ datasets</p></li> @@ -198,23 +132,17 @@ <li><p>‘transform_odeparms’, ‘backtransform_odeparms’: Use logit transformation for solitary fractions like the g parameter of the DFOP model, or formation fractions for a pathway to only one target variable</p></li> <li><p>‘plot.mmkin’: Add a ylab argument, making it possible to customize the y axis label of the panels on the left without affecting the residual plots. Reduce legend size and vertical distance between panels</p></li> <li><p>‘plot.mkinfit’: Change default ylab from “Observed” to “Residue”. Pass xlab to residual plot if show_residuals is TRUE.</p></li> -</ul> -</div> -<div id="mixed-effects-models" class="section level2"> -<h2 class="hasAnchor"> -<a href="#mixed-effects-models" class="anchor"></a>Mixed-effects models</h2> -<ul> -<li><p>‘mixed.mmkin’ New container for mmkin objects for plotting with the ‘plot.mixed.mmkin’ method</p></li> +</ul></div> +<div class="section level3"> +<h3 id="mixed-effects-models-1-0-0">Mixed-effects models<a class="anchor" aria-label="anchor" href="#mixed-effects-models-1-0-0"></a></h3> +<ul><li><p>‘mixed.mmkin’ New container for mmkin objects for plotting with the ‘plot.mixed.mmkin’ method</p></li> <li><p>‘plot.mixed.mmkin’ method used for ‘nlme.mmkin’ inheriting from ‘mixed.mmkin’ (currently virtual)</p></li> <li><p>‘plot’, ‘summary’ and ‘print’ methods for ‘nlme.mmkin’ objects</p></li> -</ul> +</ul></div> </div> -</div> - <div id="mkin-09503-2020-10-08" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.50.3"> -<a href="#mkin-09503-2020-10-08" class="anchor"></a>mkin 0.9.50.3 (2020-10-08)</h1> -<ul> -<li><p>‘parms’: Add a method for mmkin objects</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.50.3" id="mkin-09503-2020-10-08">mkin 0.9.50.3 (2020-10-08)<a class="anchor" aria-label="anchor" href="#mkin-09503-2020-10-08"></a></h2> +<ul><li><p>‘parms’: Add a method for mmkin objects</p></li> <li><p>‘mmkin’ and ‘confint(method = ’profile’): Use all cores detected by parallel::detectCores() per default</p></li> <li><p>‘confint(method = ’profile’): Choose accuracy based on ‘rel_tol’ argument, relative to the bounds obtained by the quadratic approximation</p></li> <li><p>‘mkinfit’: Make ‘use_of_ff’ = “max” also the default for models specified using short names like “SFO” or “FOMC”</p></li> @@ -223,76 +151,52 @@ <li><p>‘mmkin’: Do not fail any more if one of the fits fails, but assign the try-error to the respective position in the mmkin object</p></li> <li><p>‘mkinfit’: Ignore components of state.ini that do not correspond to state variables in the model</p></li> <li><p>‘endpoints’: Back-calculate DT50 value from DT90 also for the biphasic models DFOP, HS and SFORB</p></li> -</ul> -</div> - <div id="mkin-09502-2020-05-12" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.50.2"> -<a href="#mkin-09502-2020-05-12" class="anchor"></a>mkin 0.9.50.2 (2020-05-12)</h1> -<ul> -<li><p>Increase tolerance for a platform specific test results on the Solaris test machine on CRAN</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.50.2" id="mkin-09502-2020-05-12">mkin 0.9.50.2 (2020-05-12)<a class="anchor" aria-label="anchor" href="#mkin-09502-2020-05-12"></a></h2> +<ul><li><p>Increase tolerance for a platform specific test results on the Solaris test machine on CRAN</p></li> <li><p>Updates and corrections (using the spelling package) to the documentation</p></li> -</ul> -</div> - <div id="mkin-09501-2020-05-11" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.50.1"> -<a href="#mkin-09501-2020-05-11" class="anchor"></a>mkin 0.9.50.1 (2020-05-11)</h1> -<ul> -<li><p>Support SFORB with formation fractions</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.50.1" id="mkin-09501-2020-05-11">mkin 0.9.50.1 (2020-05-11)<a class="anchor" aria-label="anchor" href="#mkin-09501-2020-05-11"></a></h2> +<ul><li><p>Support SFORB with formation fractions</p></li> <li><p>‘mkinmod’: Make ‘use_of_ff’ = “max” the default</p></li> <li><p>Improve performance by a) avoiding expensive calls in the cost function like merge() and data.frame(), and b) by implementing analytical solutions for SFO-SFO and DFOP-SFO</p></li> -</ul> -</div> - <div id="mkin-094911-2020-04-20" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.11"> -<a href="#mkin-094911-2020-04-20" class="anchor"></a>mkin 0.9.49.11 (2020-04-20)</h1> -<ul> -<li>Increase a test tolerance to make it pass on all CRAN check machines</li> -</ul> -</div> - <div id="mkin-094910-2020-04-18" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.10"> -<a href="#mkin-094910-2020-04-18" class="anchor"></a>mkin 0.9.49.10 (2020-04-18)</h1> -<ul> -<li><p>‘nlme.mmkin’: An nlme method for mmkin row objects and an associated S3 class with print, plot, anova and endpoint methods</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.11" id="mkin-094911-2020-04-20">mkin 0.9.49.11 (2020-04-20)<a class="anchor" aria-label="anchor" href="#mkin-094911-2020-04-20"></a></h2> +<ul><li>Increase a test tolerance to make it pass on all CRAN check machines</li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.10" id="mkin-094910-2020-04-18">mkin 0.9.49.10 (2020-04-18)<a class="anchor" aria-label="anchor" href="#mkin-094910-2020-04-18"></a></h2> +<ul><li><p>‘nlme.mmkin’: An nlme method for mmkin row objects and an associated S3 class with print, plot, anova and endpoint methods</p></li> <li><p>‘mean_degparms, nlme_data, nlme_function’: Three new functions to facilitate building nlme models from mmkin row objects</p></li> <li><p>‘endpoints’: Don’t return the SFORB list component if it’s empty. This reduces distraction and complies with the documentation</p></li> <li><p>Article in compiled models: Add some platform specific code and suppress warnings about zero values being removed from the FOCUS D dataset</p></li> <li><p>‘plot.mmkin’: Add the argument ‘standardized’ to avoid warnings that occurred when it was passed as part of the additional arguments captured by the dots (…)</p></li> <li><p>‘summary.mkinfit’: Add AIC, BIC and log likelihood to the summary</p></li> -</ul> -</div> - <div id="mkin-09499-2020-03-31" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.9"> -<a href="#mkin-09499-2020-03-31" class="anchor"></a>mkin 0.9.49.9 (2020-03-31)</h1> -<ul> -<li><p>‘mkinmod’: Use pkgbuild::has_compiler instead of Sys.which(‘gcc’), as the latter will often fail even if Rtools are installed</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.9" id="mkin-09499-2020-03-31">mkin 0.9.49.9 (2020-03-31)<a class="anchor" aria-label="anchor" href="#mkin-09499-2020-03-31"></a></h2> +<ul><li><p>‘mkinmod’: Use pkgbuild::has_compiler instead of Sys.which(‘gcc’), as the latter will often fail even if Rtools are installed</p></li> <li><p>‘mkinds’: Use roxygen for documenting fields and methods of this R6 class</p></li> -</ul> -</div> - <div id="mkin-09498-2020-01-09" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.8"> -<a href="#mkin-09498-2020-01-09" class="anchor"></a>mkin 0.9.49.8 (2020-01-09)</h1> -<ul> -<li><p>‘aw’: Generic function for calculating Akaike weights, methods for mkinfit objects and mmkin columns</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.8" id="mkin-09498-2020-01-09">mkin 0.9.49.8 (2020-01-09)<a class="anchor" aria-label="anchor" href="#mkin-09498-2020-01-09"></a></h2> +<ul><li><p>‘aw’: Generic function for calculating Akaike weights, methods for mkinfit objects and mmkin columns</p></li> <li><p>‘loftest’: Add a lack-of-fit test</p></li> <li><p>‘plot_res’, ‘plot_sep’ and ‘mkinerrplot’: Add the possibility to show standardized residuals and make it the default for fits with error models other than ‘const’</p></li> <li><p>‘lrtest.mkinfit’: Improve naming of the compared fits in the case of fixed parameters</p></li> <li><p>‘confint.mkinfit’: Make the quadratic approximation the default, as the likelihood profiling takes a lot of time, especially if the fit has more than three parameters</p></li> -</ul> -</div> - <div id="mkin-09497-2019-11-01" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.7"> -<a href="#mkin-09497-2019-11-01" class="anchor"></a>mkin 0.9.49.7 (2019-11-01)</h1> -<ul> -<li><p>Fix a bug introduced in 0.9.49.6 that occurred if the direct optimisation yielded a higher likelihood than the three-step optimisation in the d_3 algorithm, which caused the fitted parameters of the three-step optimisation to be returned instead of the parameters of the direct optimisation</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.7" id="mkin-09497-2019-11-01">mkin 0.9.49.7 (2019-11-01)<a class="anchor" aria-label="anchor" href="#mkin-09497-2019-11-01"></a></h2> +<ul><li><p>Fix a bug introduced in 0.9.49.6 that occurred if the direct optimisation yielded a higher likelihood than the three-step optimisation in the d_3 algorithm, which caused the fitted parameters of the three-step optimisation to be returned instead of the parameters of the direct optimisation</p></li> <li><p>Add a ‘nobs’ method for mkinfit objects, enabling the default ‘BIC’ method from the stats package. Also, add a ‘BIC’ method for mmkin column objects.</p></li> -</ul> -</div> - <div id="mkin-09496-2019-10-31" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.6"> -<a href="#mkin-09496-2019-10-31" class="anchor"></a>mkin 0.9.49.6 (2019-10-31)</h1> -<ul> -<li><p>Implement a likelihood ratio test as a method for ‘lrtest’ from the lmtest package</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.6" id="mkin-09496-2019-10-31">mkin 0.9.49.6 (2019-10-31)<a class="anchor" aria-label="anchor" href="#mkin-09496-2019-10-31"></a></h2> +<ul><li><p>Implement a likelihood ratio test as a method for ‘lrtest’ from the lmtest package</p></li> <li><p>Add an ‘update’ method for mkinfit objects which remembers fitted parameters if appropriate</p></li> <li><p>Add a ‘residuals’ method for mkinfit objects that supports scaling based on the error model</p></li> <li><p>Fix a bug in ‘mkinfit’ that prevented summaries of objects fitted with fixed parameters to be generated</p></li> @@ -305,13 +209,10 @@ <li><p>Update README and the introductory vignette</p></li> <li><p>Report ‘OLS’ as error_model_algorithm in the summary in the case that the default error_model (‘const’) is used</p></li> <li><p>Support summarizing ‘mkinfit’ objects generated with versions < 0.9.49.5</p></li> -</ul> -</div> - <div id="mkin-09495-2019-07-04" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.49.5"> -<a href="#mkin-09495-2019-07-04" class="anchor"></a>mkin 0.9.49.5 (2019-07-04)</h1> -<ul> -<li><p>Several algorithms for minimization of the negative log-likelihood for non-constant error models (two-component and variance by variable). In the case the error model is constant variance, least squares is used as this is more stable. The default algorithm ‘d_3’ tries direct minimization and a three-step procedure, and returns the model with the highest likelihood.</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.49.5" id="mkin-09495-2019-07-04">mkin 0.9.49.5 (2019-07-04)<a class="anchor" aria-label="anchor" href="#mkin-09495-2019-07-04"></a></h2> +<ul><li><p>Several algorithms for minimization of the negative log-likelihood for non-constant error models (two-component and variance by variable). In the case the error model is constant variance, least squares is used as this is more stable. The default algorithm ‘d_3’ tries direct minimization and a three-step procedure, and returns the model with the highest likelihood.</p></li> <li><p>The argument ‘reweight.method’ to mkinfit and mmkin is now obsolete, use ‘error_model’ and ‘error_model_algorithm’ instead</p></li> <li><p>Add a test that checks if we get the best known AIC for parent only fits to 12 test datasets. Add these test datasets for this purpose.</p></li> <li><p>New function ‘mkinerrplot’. This function is also used for residual plots in ‘plot.mmkin’ if the argument ‘resplot = “errmod”’ is given, and in ‘plot.mkinfit’ if ‘show_errplot’ is set to TRUE.</p></li> @@ -323,13 +224,10 @@ <li><p>Adapt tests</p></li> <li><p>Fix an error in the FOCUS chi2 error level calculations that occurred if parameters were specified in parms.ini that were not in the model. A warning was already issued, but when fitting in parallel via mmkin this could go unnoticed.</p></li> <li><p>Add example datasets obtained from risk assessment reports published by the European Food Safety Agency.</p></li> -</ul> -</div> - <div id="mkin-09481-2019-03-04" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.48.1"> -<a href="#mkin-09481-2019-03-04" class="anchor"></a>mkin 0.9.48.1 (2019-03-04)</h1> -<ul> -<li><p>Add the function ‘logLik.mkinfit’ which makes it possible to calculate an AIC for mkinfit objects</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.48.1" id="mkin-09481-2019-03-04">mkin 0.9.48.1 (2019-03-04)<a class="anchor" aria-label="anchor" href="#mkin-09481-2019-03-04"></a></h2> +<ul><li><p>Add the function ‘logLik.mkinfit’ which makes it possible to calculate an AIC for mkinfit objects</p></li> <li><p>Add the function ‘AIC.mmkin’ to make it easy to compare columns of mmkin objects</p></li> <li><p>‘add_err’: Respect the argument giving the number of replicates in the synthetic dataset</p></li> <li><p>‘max_twa_parent’: Support maximum time weighted average concentration calculations for the hockey stick (HS) model</p></li> @@ -339,468 +237,317 @@ <li><p>Add the function ‘CAKE_export’ to facilitate cross-checking of results</p></li> <li><p>Implement the logistic model (only tested for parent fits)</p></li> <li><p>‘nafta’: Add evaluations according to the NAFTA guidance</p></li> -</ul> -</div> - <div id="mkin-09475-2018-09-14" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.47.5"> -<a href="#mkin-09475-2018-09-14" class="anchor"></a>mkin 0.9.47.5 (2018-09-14)</h1> -<ul> -<li><p>Make the two-component error model stop in cases where it is inadequate to avoid nls crashes on windows</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.47.5" id="mkin-09475-2018-09-14">mkin 0.9.47.5 (2018-09-14)<a class="anchor" aria-label="anchor" href="#mkin-09475-2018-09-14"></a></h2> +<ul><li><p>Make the two-component error model stop in cases where it is inadequate to avoid nls crashes on windows</p></li> <li><p>Move two vignettes to a location where they will not be built on CRAN (to avoid more NOTES from long execution times)</p></li> <li><p>Exclude more example code from testing on CRAN to avoid NOTES from long execution times</p></li> -</ul> -</div> - <div id="mkin-09473" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.47.3"> -<a href="#mkin-09473" class="anchor"></a>mkin 0.9.47.3</h1> -<ul> -<li><p>‘mkinfit’: Improve fitting the error model for reweight.method = ‘tc’. Add ‘manual’ to possible arguments for ‘weight’</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.47.3" id="mkin-09473">mkin 0.9.47.3<a class="anchor" aria-label="anchor" href="#mkin-09473"></a></h2> +<ul><li><p>‘mkinfit’: Improve fitting the error model for reweight.method = ‘tc’. Add ‘manual’ to possible arguments for ‘weight’</p></li> <li><p>Test that FOCUS_2006_C can be evaluated with DFOP and reweight.method = ‘tc’</p></li> -</ul> -</div> - <div id="mkin-09472-2018-07-19" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.47.2"> -<a href="#mkin-09472-2018-07-19" class="anchor"></a>mkin 0.9.47.2 (2018-07-19)</h1> -<ul> -<li><p>‘sigma_twocomp’: Rename ‘sigma_rl’ to ‘sigma_twocomp’ as the Rocke and Lorenzato model assumes lognormal distribution for large y. Correct references to the Rocke and Lorenzato model accordingly.</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.47.2" id="mkin-09472-2018-07-19">mkin 0.9.47.2 (2018-07-19)<a class="anchor" aria-label="anchor" href="#mkin-09472-2018-07-19"></a></h2> +<ul><li><p>‘sigma_twocomp’: Rename ‘sigma_rl’ to ‘sigma_twocomp’ as the Rocke and Lorenzato model assumes lognormal distribution for large y. Correct references to the Rocke and Lorenzato model accordingly.</p></li> <li><p>‘mkinfit’: Use 1.1 as starting value for N parameter of IORE models to obtain convergence in more difficult cases. Show parameter names when ‘trace_parms’ is ‘TRUE’.</p></li> -</ul> -</div> - <div id="mkin-09471-2018-02-06" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.47.1"> -<a href="#mkin-09471-2018-02-06" class="anchor"></a>mkin 0.9.47.1 (2018-02-06)</h1> -<ul> -<li><p>Skip some tests on CRAN and winbuilder to avoid timeouts</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.47.1" id="mkin-09471-2018-02-06">mkin 0.9.47.1 (2018-02-06)<a class="anchor" aria-label="anchor" href="#mkin-09471-2018-02-06"></a></h2> +<ul><li><p>Skip some tests on CRAN and winbuilder to avoid timeouts</p></li> <li><p>‘test_data_from_UBA_2014’: Added this list of datasets containing experimental data used in the expertise from 2014</p></li> <li><p>‘mkinfit’: Added the iterative reweighting method ‘tc’ using the two-component error model from Rocke and Lorenzato. NA values in the data are not returned any more.</p></li> <li><p>‘mkinfit’: Work around a bug in the current FME version that prevented the convergence message to be returned in the case of non-convergence.</p></li> <li><p>‘summary.mkinfit’: Improved output regarding weighting method. No predictions are returned for NA values in the model (see above).</p></li> <li><p>‘summary.mkinfit’: Show versions of mkin and R used for fitting (not the ones used for the summary) if the fit was generated with mkin >= 0.9.47.1</p></li> -</ul> -</div> - <div id="mkin-09463-2017-11-16" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.46.3"> -<a href="#mkin-09463-2017-11-16" class="anchor"></a>mkin 0.9.46.3 (2017-11-16)</h1> -<ul> -<li><p><code>README.md</code>, <code>vignettes/mkin.Rmd</code>: URLs were updated</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.46.3" id="mkin-09463-2017-11-16">mkin 0.9.46.3 (2017-11-16)<a class="anchor" aria-label="anchor" href="#mkin-09463-2017-11-16"></a></h2> +<ul><li><p><code>README.md</code>, <code>vignettes/mkin.Rmd</code>: URLs were updated</p></li> <li><p><code>synthetic_data_for_UBA</code>: Add the code used to generate the data in the interest of reproducibility</p></li> -</ul> -</div> - <div id="mkin-09462-2017-10-10" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.46.2"> -<a href="#mkin-09462-2017-10-10" class="anchor"></a>mkin 0.9.46.2 (2017-10-10)</h1> -<ul> -<li><p>Converted the vignette FOCUS_Z from tex/pdf to markdown/html</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.46.2" id="mkin-09462-2017-10-10">mkin 0.9.46.2 (2017-10-10)<a class="anchor" aria-label="anchor" href="#mkin-09462-2017-10-10"></a></h2> +<ul><li><p>Converted the vignette FOCUS_Z from tex/pdf to markdown/html</p></li> <li><p><code>DESCRIPTION</code>: Add ORCID</p></li> -</ul> -</div> - <div id="mkin-09461-2017-09-14" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.46.1"> -<a href="#mkin-09461-2017-09-14" class="anchor"></a>mkin 0.9.46.1 (2017-09-14)</h1> -<ul> -<li><p><code>plot.mkinfit</code>: Fix scaling of residual plots for the case of separate plots for each observed variable</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.46.1" id="mkin-09461-2017-09-14">mkin 0.9.46.1 (2017-09-14)<a class="anchor" aria-label="anchor" href="#mkin-09461-2017-09-14"></a></h2> +<ul><li><p><code>plot.mkinfit</code>: Fix scaling of residual plots for the case of separate plots for each observed variable</p></li> <li><p><code>plot.mkinfit</code>: Use all data points of the fitted curve for y axis scaling for the case of separate plots for each observed variable</p></li> <li><p>Documentation updates</p></li> -</ul> -</div> - <div id="mkin-0946-2017-07-24" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.46"> -<a href="#mkin-0946-2017-07-24" class="anchor"></a>mkin 0.9.46 (2017-07-24)</h1> -<ul> -<li>Remove <code>test_FOMC_ill-defined.R</code> as it is too platform dependent</li> -</ul> -</div> - <div id="mkin-09452-2017-07-24" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.45.2"> -<a href="#mkin-09452-2017-07-24" class="anchor"></a>mkin 0.9.45.2 (2017-07-24)</h1> -<ul> -<li><p>Rename <code>twa</code> to <code>max_twa_parent</code> to avoid conflict with <code>twa</code> from my <code>pfm</code> package</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.46" id="mkin-0946-2017-07-24">mkin 0.9.46 (2017-07-24)<a class="anchor" aria-label="anchor" href="#mkin-0946-2017-07-24"></a></h2> +<ul><li>Remove <code>test_FOMC_ill-defined.R</code> as it is too platform dependent</li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.45.2" id="mkin-09452-2017-07-24">mkin 0.9.45.2 (2017-07-24)<a class="anchor" aria-label="anchor" href="#mkin-09452-2017-07-24"></a></h2> +<ul><li><p>Rename <code>twa</code> to <code>max_twa_parent</code> to avoid conflict with <code>twa</code> from my <code>pfm</code> package</p></li> <li><p>Update URLs in documentation</p></li> <li><p>Limit test code to one core to pass on windows</p></li> <li><p>Switch from <code>microbenchmark</code> to <code>rbenchmark</code> as the former is not supported on all platforms</p></li> -</ul> -</div> - <div id="mkin-09451-2016-12-20" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.45.1"> -<a href="#mkin-09451-2016-12-20" class="anchor"></a>mkin 0.9.45.1 (2016-12-20)</h1> -<div id="new-features" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features" class="anchor"></a>New features</h2> -<ul> -<li>A <code>twa</code> function, calculating maximum time weighted average concentrations for the parent (SFO, FOMC and DFOP).</li> -</ul> -</div> -</div> - <div id="mkin-0945-2016-12-08" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.45"> -<a href="#mkin-0945-2016-12-08" class="anchor"></a>mkin 0.9.45 (2016-12-08)</h1> -<div id="minor-changes" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes" class="anchor"></a>Minor changes</h2> -<ul> -<li><p><code>plot.mkinfit</code> and <code>plot.mmkin</code>: If the plotting device is <code>tikz</code>, LaTeX markup is being used for the chi2 error in the graphs.</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.45.1" id="mkin-09451-2016-12-20">mkin 0.9.45.1 (2016-12-20)<a class="anchor" aria-label="anchor" href="#mkin-09451-2016-12-20"></a></h2> +<div class="section level3"> +<h3 id="new-features-0-9-45-1">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-45-1"></a></h3> +<ul><li>A <code>twa</code> function, calculating maximum time weighted average concentrations for the parent (SFO, FOMC and DFOP).</li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.45" id="mkin-0945-2016-12-08">mkin 0.9.45 (2016-12-08)<a class="anchor" aria-label="anchor" href="#mkin-0945-2016-12-08"></a></h2> +<div class="section level3"> +<h3 id="minor-changes-0-9-45">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-45"></a></h3> +<ul><li><p><code>plot.mkinfit</code> and <code>plot.mmkin</code>: If the plotting device is <code>tikz</code>, LaTeX markup is being used for the chi2 error in the graphs.</p></li> <li><p>Use <code>pkgdown</code>, the successor of <code>staticdocs</code> for generating static HTML documentation. Include example output and graphs also for <code>dontrun</code> sections.</p></li> <li><p><code>plot.mkinfit</code>: Plotting does not fail any more when the compiled model is not available, e.g. because it was removed from the temporary directory. In this case, the uncompiled model is now used for plotting</p></li> -</ul> -</div> -</div> - <div id="mkin-0944-2016-06-29" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.44"> -<a href="#mkin-0944-2016-06-29" class="anchor"></a>mkin 0.9.44 (2016-06-29)</h1> -<div id="bug-fixes" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes" class="anchor"></a>Bug fixes</h2> -<ul> -<li>The test <code>test_FOMC_ill-defined</code> failed on several architectures, so the test is now skipped</li> -</ul> -</div> -</div> - <div id="mkin-0943-2016-06-28" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.43"> -<a href="#mkin-0943-2016-06-28" class="anchor"></a>mkin 0.9.43 (2016-06-28)</h1> -<div id="major-changes" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes" class="anchor"></a>Major changes</h2> -<ul> -<li><p>The title was changed to <code>Kinetic evaluations of chemical degradation data</code></p></li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.44" id="mkin-0944-2016-06-29">mkin 0.9.44 (2016-06-29)<a class="anchor" aria-label="anchor" href="#mkin-0944-2016-06-29"></a></h2> +<div class="section level3"> +<h3 id="bug-fixes-0-9-44">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-44"></a></h3> +<ul><li>The test <code>test_FOMC_ill-defined</code> failed on several architectures, so the test is now skipped</li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.43" id="mkin-0943-2016-06-28">mkin 0.9.43 (2016-06-28)<a class="anchor" aria-label="anchor" href="#mkin-0943-2016-06-28"></a></h2> +<div class="section level3"> +<h3 id="major-changes-0-9-43">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-43"></a></h3> +<ul><li><p>The title was changed to <code>Kinetic evaluations of chemical degradation data</code></p></li> <li><p><code>plot.mkinfit</code>: Add the possibility to show fits (and residual plots if requested) separately for the observed variables</p></li> <li><p><code>plot.mkinfit</code>: Add the possibility to show the chi2 error levels in the plot, similar to the way they are shown in <code>plot.mmkin</code></p></li> <li><p><code>plot_sep</code>: Add this function as a convenience wrapper for plotting observed variables of mkinfit objects separately, with chi2 error values and residual plots.</p></li> <li><p>Vignettes: The main vignette <code>mkin</code> was converted to R markdown and updated. The other vignettes were also updated to show current improved functionality.</p></li> <li><p>The function <code>add_err</code> was added to the package, making it easy to generate simulated data using an error model based on the normal distribution</p></li> -</ul> -</div> -<div id="minor-changes-1" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-1" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>Remove an outdated reference to the inline package in the <code>compiled_models</code> vignette</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-43">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-43"></a></h3> +<ul><li><p>Remove an outdated reference to the inline package in the <code>compiled_models</code> vignette</p></li> <li><p><code>mkinfit</code>: Do not error out in cases where the fit converges, but the Jacobian for the untransformed model cost can not be estimated. Give a warning instead and return NA for the t-test results.</p></li> <li><p><code>summary.mkinfit</code>: Give a warning message when the covariance matrix can not be obtained.</p></li> <li><p>A test has been added to containing a corresponding edge case to check that the warnings are correctly issued and the fit does not terminate.</p></li> <li><p><code>plot.mmkin</code>: Round the chi2 error value to three significant digits, instead of two decimal digits.</p></li> <li><p><code>mkinfit</code>: Return the <code>err</code> values used on weighted fits as a column named <code>err</code>. Also include these inverse weights when the column <code>value</code> in the observed data is used, which is returned as <code>observed</code> in the data component of the mkinfit object.</p></li> -</ul> -</div> -<div id="bug-fixes-1" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-1" class="anchor"></a>Bug fixes</h2> -<ul> -<li><p><code>endpoints</code>: When the name of a substance degrading to a metabolite (e.g. a parent compound) used in the model formulation ended in the letter <code>f</code>, some rate parameters could be listed as formation fractions with mixed up names. These would also appear in the summary.</p></li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-43">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-43"></a></h3> +<ul><li><p><code>endpoints</code>: When the name of a substance degrading to a metabolite (e.g. a parent compound) used in the model formulation ended in the letter <code>f</code>, some rate parameters could be listed as formation fractions with mixed up names. These would also appear in the summary.</p></li> <li><p><code>mkinfit</code>: Check for all observed variables when checking if the user tried to fix formation fractions when fitting them using ilr transformation.</p></li> <li><p><code>plot.mmkin</code>: Set the plot margins correctly, also in the case of a single fit to be plotted, so the main title is placed in a reasonable way.</p></li> <li><p><code>plot.mkinfit</code>: Correct default values for <code>col_obs</code>, <code>pch_obs</code> and <code>lty_obs</code> for the case that <code>obs_vars</code> is specified.</p></li> -</ul> -</div> -</div> - <div id="mkin-0942-2016-03-25" class="section level1"> -<h1 class="page-header" data-toc-text="0.9.42"> -<a href="#mkin-0942-2016-03-25" class="anchor"></a>mkin 0.9.42 (2016-03-25)</h1> -<div id="major-changes-1" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes-1" class="anchor"></a>Major changes</h2> -<ul> -<li>Add the argument <code>from_max_mean</code> to <code>mkinfit</code>, for fitting only the decline from the maximum observed value for models with a single observed variable</li> -</ul> -</div> -<div id="minor-changes-2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-2" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>Add plots to <code>compiled_models</code> vignette</p></li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9.42" id="mkin-0942-2016-03-25">mkin 0.9.42 (2016-03-25)<a class="anchor" aria-label="anchor" href="#mkin-0942-2016-03-25"></a></h2> +<div class="section level3"> +<h3 id="major-changes-0-9-42">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-42"></a></h3> +<ul><li>Add the argument <code>from_max_mean</code> to <code>mkinfit</code>, for fitting only the decline from the maximum observed value for models with a single observed variable</li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-42">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-42"></a></h3> +<ul><li><p>Add plots to <code>compiled_models</code> vignette</p></li> <li><p>Give an explanatory error message when mkinmod fails due to a missing definition of a target variable</p></li> <li><p><code><a href="../reference/mkinmod.html">print.mkinmod()</a></code>: Improve formatting when printing mkinmod model definitions</p></li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-41-2015-11-09" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-41"> -<a href="#mkin-09-41-2015-11-09" class="anchor"></a>mkin 0.9-41 (2015-11-09)</h1> -<div id="minor-changes-3" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-3" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>Add an R6 class <code>mkinds</code> representing datasets with a printing method</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-41" id="mkin-09-41-2015-11-09">mkin 0.9-41 (2015-11-09)<a class="anchor" aria-label="anchor" href="#mkin-09-41-2015-11-09"></a></h2> +<div class="section level3"> +<h3 id="minor-changes-0-9-41">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-41"></a></h3> +<ul><li><p>Add an R6 class <code>mkinds</code> representing datasets with a printing method</p></li> <li><p>Add a printing method for mkinmod objects</p></li> <li><p>Make it possible to specify arbitrary strings as names for the compounds in <code>mkinmod</code>, and show them in the plot</p></li> <li><p>Use an index.r file to group help topics in static documentation</p></li> -</ul> -</div> -<div id="bug-fixes-2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-2" class="anchor"></a>Bug fixes</h2> -<ul> -<li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-41">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-41"></a></h3> +<ul><li> <code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Avoid an error that occurred when printing summaries generated with mkin versions before 0.9-36</li> -</ul> -</div> -</div> - <div id="mkin-09-40-2015-07-21" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-40"> -<a href="#mkin-09-40-2015-07-21" class="anchor"></a>mkin 0.9-40 (2015-07-21)</h1> -<div id="bug-fixes-3" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-3" class="anchor"></a>Bug fixes</h2> -<ul> -<li> -<code><a href="../reference/endpoints.html">endpoints()</a></code>: For DFOP and SFORB models, where <code><a href="https://rdrr.io/r/stats/optimize.html">optimize()</a></code> is used, make use of the fact that the DT50 must be between DT50_k1 and DT50_k2 (DFOP) or DT50_b1 and DT50_b2 (SFORB), as <code><a href="https://rdrr.io/r/stats/optimize.html">optimize()</a></code> sometimes did not find the minimum. Likewise for finding DT90 values. Also fit on the log scale to make the function more efficient.</li> -</ul> -</div> -<div id="internal-changes" class="section level2"> -<h2 class="hasAnchor"> -<a href="#internal-changes" class="anchor"></a>Internal changes</h2> -<ul> -<li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-40" id="mkin-09-40-2015-07-21">mkin 0.9-40 (2015-07-21)<a class="anchor" aria-label="anchor" href="#mkin-09-40-2015-07-21"></a></h2> +<div class="section level3"> +<h3 id="bug-fixes-0-9-40">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-40"></a></h3> +<ul><li> +<code><a href="../reference/endpoints.html">endpoints()</a></code>: For DFOP and SFORB models, where <code><a href="https://rdrr.io/r/stats/optimize.html" class="external-link">optimize()</a></code> is used, make use of the fact that the DT50 must be between DT50_k1 and DT50_k2 (DFOP) or DT50_b1 and DT50_b2 (SFORB), as <code><a href="https://rdrr.io/r/stats/optimize.html" class="external-link">optimize()</a></code> sometimes did not find the minimum. Likewise for finding DT90 values. Also fit on the log scale to make the function more efficient.</li> +</ul></div> +<div class="section level3"> +<h3 id="internal-changes-0-9-40">Internal changes<a class="anchor" aria-label="anchor" href="#internal-changes-0-9-40"></a></h3> +<ul><li> <code>DESCRIPTION</code>, <code>NAMESPACE</code>, <code>R/*.R</code>: Import (from) stats, graphics and methods packages, and qualify some function calls for non-base packages installed with R to avoid NOTES made by R CMD check –as-cran with upcoming R versions.</li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-39-2015-06-26" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-39"> -<a href="#mkin-09-39-2015-06-26" class="anchor"></a>mkin 0.9-39 (2015-06-26)</h1> -<div id="major-changes-2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes-2" class="anchor"></a>Major changes</h2> -<ul> -<li><p>New function <code><a href="../reference/mmkin.html">mmkin()</a></code>: This function takes a character vector of model shorthand names, or alternatively a list of mkinmod models, as well as a list of dataset as main arguments. It returns a matrix of mkinfit objects, with a row for each model and a column for each dataset. A subsetting method with single brackets is available. Fitting the models in parallel using the <code>parallel</code> package is supported.</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-39" id="mkin-09-39-2015-06-26">mkin 0.9-39 (2015-06-26)<a class="anchor" aria-label="anchor" href="#mkin-09-39-2015-06-26"></a></h2> +<div class="section level3"> +<h3 id="major-changes-0-9-39">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-39"></a></h3> +<ul><li><p>New function <code><a href="../reference/mmkin.html">mmkin()</a></code>: This function takes a character vector of model shorthand names, or alternatively a list of mkinmod models, as well as a list of dataset as main arguments. It returns a matrix of mkinfit objects, with a row for each model and a column for each dataset. A subsetting method with single brackets is available. Fitting the models in parallel using the <code>parallel</code> package is supported.</p></li> <li><p>New function <code><a href="../reference/plot.mmkin.html">plot.mmkin()</a></code>: Plots single-row or single-column <code>mmkin</code> objects including residual plots.</p></li> -</ul> -</div> -<div id="bug-fixes-4" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-4" class="anchor"></a>Bug fixes</h2> -<ul> -<li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-39">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-39"></a></h3> +<ul><li> <code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Fix the x axis scaling for rate constants and formation fractions that got confused by the introduction of the t-values of transformed parameters.</li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-38-2015-06-24" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-38"> -<a href="#mkin-09-38-2015-06-24" class="anchor"></a>mkin 0.9-38 (2015-06-24)</h1> -<div id="minor-changes-4" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-4" class="anchor"></a>Minor changes</h2> -<ul> -<li><p><code>vignettes/compiled_models.html</code>: Show the performance improvement factor actually obtained when building the vignette, as well as mkin version, some system info and the CPU model used for building the vignette.</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-38" id="mkin-09-38-2015-06-24">mkin 0.9-38 (2015-06-24)<a class="anchor" aria-label="anchor" href="#mkin-09-38-2015-06-24"></a></h2> +<div class="section level3"> +<h3 id="minor-changes-0-9-38">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-38"></a></h3> +<ul><li><p><code>vignettes/compiled_models.html</code>: Show the performance improvement factor actually obtained when building the vignette, as well as mkin version, some system info and the CPU model used for building the vignette.</p></li> <li><p><code>GNUMakefile</code>,<code>vignettes/*</code>: Clean up vignette generation and include table of contents in HTML vignettes.</p></li> -</ul> -</div> -<div id="bug-fixes-5" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-5" class="anchor"></a>Bug fixes</h2> -<ul> -<li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-38">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-38"></a></h3> +<ul><li> <code><a href="../reference/mkinmod.html">mkinmod()</a></code>: When generating the C code for the derivatives, only declare the time variable when it is needed and remove the ‘-W-no-unused-variable’ compiler flag as the C compiler used in the CRAN checks on Solaris does not know it.</li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-36-2015-06-21" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-36"> -<a href="#mkin-09-36-2015-06-21" class="anchor"></a>mkin 0.9-36 (2015-06-21)</h1> -<div id="major-changes-3" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes-3" class="anchor"></a>Major changes</h2> -<ul> -<li><p><code><a href="../reference/summary.mkinfit.html">summary.mkinfit()</a></code>: A one-sided t-test for significant difference of untransformed parameters from zero is now always shown, based on the assumption of normal distribution for estimators of all untransformed parameters. Use with caution, as this assumption is unrealistic e.g. for rate constants in these nonlinear kinetic models.</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-36" id="mkin-09-36-2015-06-21">mkin 0.9-36 (2015-06-21)<a class="anchor" aria-label="anchor" href="#mkin-09-36-2015-06-21"></a></h2> +<div class="section level3"> +<h3 id="major-changes-0-9-36">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-36"></a></h3> +<ul><li><p><code><a href="../reference/summary.mkinfit.html">summary.mkinfit()</a></code>: A one-sided t-test for significant difference of untransformed parameters from zero is now always shown, based on the assumption of normal distribution for estimators of all untransformed parameters. Use with caution, as this assumption is unrealistic e.g. for rate constants in these nonlinear kinetic models.</p></li> <li><p>If a compiler (gcc) is installed, use a version of the differential equation model compiled from C code, which is a huge performance boost for models where only the deSolve method works.</p></li> <li><p><code><a href="../reference/mkinmod.html">mkinmod()</a></code>: Create a list component $cf (of class CFuncList) in the list returned by mkinmod, if a version can be compiled from autogenerated C code (see above).</p></li> <li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Set the default <code>solution_type</code> to <code>deSolve</code> when a compiled version of the model is present, except when an analytical solution is possible.</p></li> -</ul> -</div> -<div id="minor-changes-5" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-5" class="anchor"></a>Minor changes</h2> -<ul> -<li>Added a simple showcase vignette with an evaluation of FOCUS example dataset D</li> -</ul> -</div> -</div> - <div id="mkin-09-35-2015-05-15" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-35"> -<a href="#mkin-09-35-2015-05-15" class="anchor"></a>mkin 0.9-35 (2015-05-15)</h1> -<div id="major-changes-4" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes-4" class="anchor"></a>Major changes</h2> -<ul> -<li>Switch from RUnit to testthat for testing</li> -</ul> -</div> -<div id="bug-fixes-6" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-6" class="anchor"></a>Bug fixes</h2> -<ul> -<li><p><code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Avoid warnings that occurred when not all confidence intervals were available in the summary of the fit</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-36">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-36"></a></h3> +<ul><li>Added a simple showcase vignette with an evaluation of FOCUS example dataset D</li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-35" id="mkin-09-35-2015-05-15">mkin 0.9-35 (2015-05-15)<a class="anchor" aria-label="anchor" href="#mkin-09-35-2015-05-15"></a></h2> +<div class="section level3"> +<h3 id="major-changes-0-9-35">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-35"></a></h3> +<ul><li>Switch from RUnit to testthat for testing</li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-35">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-35"></a></h3> +<ul><li><p><code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Avoid warnings that occurred when not all confidence intervals were available in the summary of the fit</p></li> <li><p><code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Fix printing the summary for the case that the number of iterations is not available</p></li> <li><p>NAMESPACE: export S3 methods plot.mkinfit, summary.mkinfit and print.summary.mkinfit to satisfy R CMD check on R-devel</p></li> <li><p><code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Avoid warning in R CMD check about undeclared global variable <code>Lower</code></p></li> -</ul> -</div> -<div id="new-features-1" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features-1" class="anchor"></a>New features</h2> -<ul> -<li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Report successful termination when quiet = FALSE. This is helpful for more difficult problems fitted with reweight.method = obs, as no progress is often indicated during the reweighting.</p></li> +</ul></div> +<div class="section level3"> +<h3 id="new-features-0-9-35">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-35"></a></h3> +<ul><li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Report successful termination when quiet = FALSE. This is helpful for more difficult problems fitted with reweight.method = obs, as no progress is often indicated during the reweighting.</p></li> <li><p>A first test using results established in the expertise written for the German Federal Environmental Agency (UBA) was added.</p></li> <li><p>Add synthetic datasets generated for expertise written for the German Federal Environmental Agency UBA</p></li> <li><p>Add tests based on these datasets</p></li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-34-2014-11-22" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-34"> -<a href="#mkin-09-34-2014-11-22" class="anchor"></a>mkin 0.9-34 (2014-11-22)</h1> -<div id="new-features-2" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features-2" class="anchor"></a>New features</h2> -<ul> -<li><p>Add the convenience function <code><a href="../reference/mkinmod.html">mkinsub()</a></code> for creating the lists used in <code><a href="../reference/mkinmod.html">mkinmod()</a></code></p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-34" id="mkin-09-34-2014-11-22">mkin 0.9-34 (2014-11-22)<a class="anchor" aria-label="anchor" href="#mkin-09-34-2014-11-22"></a></h2> +<div class="section level3"> +<h3 id="new-features-0-9-34">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-34"></a></h3> +<ul><li><p>Add the convenience function <code><a href="../reference/mkinmod.html">mkinsub()</a></code> for creating the lists used in <code><a href="../reference/mkinmod.html">mkinmod()</a></code></p></li> <li><p>Add the possibility to fit indeterminate order rate equation (IORE) models using an analytical solution (parent only) or a numeric solution. Paths from IORE compounds to metabolites are supported when using formation fractions (use_of_ff = ‘max’). Note that the numerical solution (method.ode = ‘deSolve’) of the IORE differential equations sometimes fails due to numerical problems.</p></li> <li><p>Switch to using the Port algorithm (using a model/trust region approach) per default. While needing more iterations than the Levenberg-Marquardt algorithm previously used per default, it is less sensitive to starting parameters.</p></li> -</ul> -</div> -<div id="minor-changes-6" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-6" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>The formatting of differential equations in the summary was further improved</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-34">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-34"></a></h3> +<ul><li><p>The formatting of differential equations in the summary was further improved</p></li> <li><p>Always include 0 on y axis when plotting during the fit</p></li> -</ul> +</ul></div> </div> -</div> - <div id="mkin-09-33-2014-10-22" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-33"> -<a href="#mkin-09-33-2014-10-22" class="anchor"></a>mkin 0.9-33 (2014-10-22)</h1> -<div id="new-features-3" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features-3" class="anchor"></a>New features</h2> -<ul> -<li><p>The initial value (state.ini) for the observed variable with the highest observed residue is set to 100 in case it has no time zero observation and <code>state.ini = "auto"</code></p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-33" id="mkin-09-33-2014-10-22">mkin 0.9-33 (2014-10-22)<a class="anchor" aria-label="anchor" href="#mkin-09-33-2014-10-22"></a></h2> +<div class="section level3"> +<h3 id="new-features-0-9-33">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-33"></a></h3> +<ul><li><p>The initial value (state.ini) for the observed variable with the highest observed residue is set to 100 in case it has no time zero observation and <code>state.ini = "auto"</code></p></li> <li><p>A basic unit test for <code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code> was written</p></li> -</ul> -</div> -<div id="bug-fixes-7" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-7" class="anchor"></a>Bug fixes</h2> -<ul> -<li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: The internally fitted parameter for <code>g</code> was named <code>g_ilr</code> even when <code>transform_fractions=FALSE</code></p></li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-33">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-33"></a></h3> +<ul><li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: The internally fitted parameter for <code>g</code> was named <code>g_ilr</code> even when <code>transform_fractions=FALSE</code></p></li> <li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: The initial value (state.ini) for the parent compound was not set when the parent was not the (only) variable with the highest value in the observed data.</p></li> <li><p><code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code>: When checking for degrees of freedom for metabolites, check if their time zero value is fixed instead of checking if the observed value is zero. This ensures correct calculation of degrees of freedom also in cases where the metabolite residue at time zero is greater zero.</p></li> <li><p><code><a href="../reference/plot.mkinfit.html">plot.mkinfit()</a></code>: Avoid a warning message about only using the first component of ylim that occurred when ylim was specified explicitly</p></li> -</ul> -</div> -<div id="minor-changes-7" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-7" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>The formatting of differential equations in the summary was improved by wrapping overly long lines</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-33">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-33"></a></h3> +<ul><li><p>The formatting of differential equations in the summary was improved by wrapping overly long lines</p></li> <li><p>The FOCUS_Z vignette was rebuilt with the above improvement and using a width of 70 to avoid output outside of the grey area</p></li> <li><p><code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Avoid a warning that occurred when gmkin showed summaries of initial fits without iterations</p></li> <li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Avoid a warning that occurred when summarising a fit that was performed with maxitmodFit = 0 as done in gmkin for configuring new fits.</p></li> -</ul> +</ul></div> </div> -</div> - <div id="mkin-09-32-2014-07-24" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-32"> -<a href="#mkin-09-32-2014-07-24" class="anchor"></a>mkin 0.9-32 (2014-07-24)</h1> -<div id="new-features-4" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features-4" class="anchor"></a>New features</h2> -<ul> -<li><p>The number of degrees of freedom is difficult to define in the case of ilr transformation of formation fractions. Now for each source compartment the number of ilr parameters (=number of optimised parameters) is divided by the number of pathways to metabolites (=number of affected data series) which leads to fractional degrees of freedom in some cases.</p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-32" id="mkin-09-32-2014-07-24">mkin 0.9-32 (2014-07-24)<a class="anchor" aria-label="anchor" href="#mkin-09-32-2014-07-24"></a></h2> +<div class="section level3"> +<h3 id="new-features-0-9-32">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-32"></a></h3> +<ul><li><p>The number of degrees of freedom is difficult to define in the case of ilr transformation of formation fractions. Now for each source compartment the number of ilr parameters (=number of optimised parameters) is divided by the number of pathways to metabolites (=number of affected data series) which leads to fractional degrees of freedom in some cases.</p></li> <li><p>The default for the initial value for the first state value is now taken from the mean of the observations at time zero, if available.</p></li> <li><p>The kinetic model can alternatively be specified with a shorthand name for parent only degradation models, e.g. <code>SFO</code>, or <code>DFOP</code>.</p></li> <li><p>Optimisation method, number of model evaluations and time elapsed during optimisation are given in the summary of mkinfit objects.</p></li> <li><p>The maximum number of iterations in the optimisation algorithm can be specified using the argument <code>maxit.modFit</code> to the mkinfit function.</p></li> <li><p>mkinfit gives a warning when the fit does not converge (does not apply to SANN method). This warning is included in the summary.</p></li> -</ul> -</div> -<div id="bug-fixes-8" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-8" class="anchor"></a>Bug fixes</h2> -<ul> -<li><p>Avoid plotting an artificial 0 residual at time zero in <code>mkinresplot</code></p></li> +</ul></div> +<div class="section level3"> +<h3 id="bug-fixes-0-9-32">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-32"></a></h3> +<ul><li><p>Avoid plotting an artificial 0 residual at time zero in <code>mkinresplot</code></p></li> <li><p>In the determination of the degrees of freedom in <code>mkinerrmin</code>, formation fractions were accounted for multiple times in the case of parallel formation of metabolites. See the new feature described above for the solution.</p></li> <li><p><code>transform_rates=FALSE</code> in <code>mkinfit</code> now also works for FOMC and HS models.</p></li> <li><p>Initial values for formation fractions were not set in all cases.</p></li> <li><p>No warning was given when the fit did not converge when a method other than the default Levenberg-Marquardt method <code>Marq</code> was used.</p></li> -</ul> -</div> -<div id="minor-changes-8" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-8" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>Vignettes were rebuilt to reflect the changes in the summary method.</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-32">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-32"></a></h3> +<ul><li><p>Vignettes were rebuilt to reflect the changes in the summary method.</p></li> <li><p>Algorithm <code>Pseudo</code> was excluded because it needs user-defined parameter limits which are not supported.</p></li> <li><p>Algorithm <code>Newton</code> was excluded because of its different way to specify the maximum number of iterations and because it does not appear to provide additional benefits.</p></li> -</ul> -</div> -</div> - <div id="mkin-09-31-2014-07-14" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-31"> -<a href="#mkin-09-31-2014-07-14" class="anchor"></a>mkin 0.9-31 (2014-07-14)</h1> -<div id="bug-fixes-9" class="section level2"> -<h2 class="hasAnchor"> -<a href="#bug-fixes-9" class="anchor"></a>Bug fixes</h2> -<ul> -<li>The internal renaming of optimised parameters in Version 0.9-30 led to errors in the determination of the degrees of freedom for the chi2 error level calulations in <code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code> used by the summary function.</li> -</ul> -</div> -</div> - <div id="mkin-09-30-2014-07-11" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-30"> -<a href="#mkin-09-30-2014-07-11" class="anchor"></a>mkin 0.9-30 (2014-07-11)</h1> -<div id="new-features-5" class="section level2"> -<h2 class="hasAnchor"> -<a href="#new-features-5" class="anchor"></a>New features</h2> -<ul> -<li>It is now possible to use formation fractions in combination with turning off the sink in <code><a href="../reference/mkinmod.html">mkinmod()</a></code>.</li> -</ul> -</div> -<div id="major-changes-5" class="section level2"> -<h2 class="hasAnchor"> -<a href="#major-changes-5" class="anchor"></a>Major changes</h2> -<ul> -<li><p>The original and the transformed parameters now have different names (e.g. <code>k_parent</code> and <code>log_k_parent</code>. They also differ in how many they are when we have formation fractions but no pathway to sink.</p></li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-31" id="mkin-09-31-2014-07-14">mkin 0.9-31 (2014-07-14)<a class="anchor" aria-label="anchor" href="#mkin-09-31-2014-07-14"></a></h2> +<div class="section level3"> +<h3 id="bug-fixes-0-9-31">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-31"></a></h3> +<ul><li>The internal renaming of optimised parameters in Version 0.9-30 led to errors in the determination of the degrees of freedom for the chi2 error level calulations in <code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code> used by the summary function.</li> +</ul></div> +</div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-30" id="mkin-09-30-2014-07-11">mkin 0.9-30 (2014-07-11)<a class="anchor" aria-label="anchor" href="#mkin-09-30-2014-07-11"></a></h2> +<div class="section level3"> +<h3 id="new-features-0-9-30">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-30"></a></h3> +<ul><li>It is now possible to use formation fractions in combination with turning off the sink in <code><a href="../reference/mkinmod.html">mkinmod()</a></code>.</li> +</ul></div> +<div class="section level3"> +<h3 id="major-changes-0-9-30">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-30"></a></h3> +<ul><li><p>The original and the transformed parameters now have different names (e.g. <code>k_parent</code> and <code>log_k_parent</code>. They also differ in how many they are when we have formation fractions but no pathway to sink.</p></li> <li><p>The order of some of the information blocks in <code>print.summary.mkinfit.R()</code> has been ordered in a more logical way.</p></li> -</ul> -</div> -<div id="minor-changes-9" class="section level2"> -<h2 class="hasAnchor"> -<a href="#minor-changes-9" class="anchor"></a>Minor changes</h2> -<ul> -<li><p>The vignette FOCUS_Z has been simplified to use formation fractions with turning off the sink, and slightly amended to use the new versions of DT50 values calculated since mkin 0.9-29.</p></li> +</ul></div> +<div class="section level3"> +<h3 id="minor-changes-0-9-30">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-30"></a></h3> +<ul><li><p>The vignette FOCUS_Z has been simplified to use formation fractions with turning off the sink, and slightly amended to use the new versions of DT50 values calculated since mkin 0.9-29.</p></li> <li><p>All vignettes have been rebuilt so they reflect all changes.</p></li> <li><p>The ChangeLog was renamed to NEWS.md and the entries were converted to markdown syntax compatible with the <code>tools::news()</code> function built into R.</p></li> <li><p>The test suite was overhauled. Tests of the DFOP and SFORB models with dataset FOCUS_2006_A were removed, as they were too much dependent on the optimisation algorithm and/or starting parameters, because the dataset is SFO (compare kinfit vignette).</p></li> <li><p>Also, the Schaefer complex case can now be fitted using formation fractions, and with the ‘Port’ optimisation method we also fit A2 in the same way as published in the Piacenza paper.</p></li> <li><p>Some more checks were introduced to <code><a href="../reference/mkinfit.html">mkinfit()</a></code>, leading to warnings or stopping execution if unsupported combinations of methods and parameters are requested.</p></li> -</ul> -</div> +</ul></div> </div> - <div id="mkin-09-29-2014-06-27" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-29"> -<a href="#mkin-09-29-2014-06-27" class="anchor"></a>mkin 0.9-29 (2014-06-27)</h1> -<ul> -<li><p>R/mkinresplot.R: Make it possible to specify <code>xlim</code></p></li> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-29" id="mkin-09-29-2014-06-27">mkin 0.9-29 (2014-06-27)<a class="anchor" aria-label="anchor" href="#mkin-09-29-2014-06-27"></a></h2> +<ul><li><p>R/mkinresplot.R: Make it possible to specify <code>xlim</code></p></li> <li><p>R/geometric_mean.R, man/geometric_mean.Rd: Add geometric mean function</p></li> <li><p>R/endpoints.R, man/endpoints.Rd: Calculate additional (pseudo)-DT50 values for FOMC, DFOP, HS and SFORB. Avoid calculation of formation fractions from rate constants when they are directly fitted</p></li> -</ul> -</div> - <div id="mkin-09-28-2014-05-20" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-28"> -<a href="#mkin-09-28-2014-05-20" class="anchor"></a>mkin 0.9-28 (2014-05-20)</h1> -<ul> -<li><p>Do not backtransform confidence intervals for formation fractions if more than one compound is formed, as such parameters only define the pathways as a set</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-28" id="mkin-09-28-2014-05-20">mkin 0.9-28 (2014-05-20)<a class="anchor" aria-label="anchor" href="#mkin-09-28-2014-05-20"></a></h2> +<ul><li><p>Do not backtransform confidence intervals for formation fractions if more than one compound is formed, as such parameters only define the pathways as a set</p></li> <li><p>Add historical remarks and some background to the main package vignette</p></li> <li><p>Correct ‘isotropic’ into ‘isometric’ for the ilr transformation</p></li> -</ul> -</div> - <div id="mkin-09-27-2014-05-10" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-27"> -<a href="#mkin-09-27-2014-05-10" class="anchor"></a>mkin 0.9-27 (2014-05-10)</h1> -<ul> -<li><p>Fork the GUI into a separate package <a href="https://github.com/jranke/gmkin">gmkin</a></p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-27" id="mkin-09-27-2014-05-10">mkin 0.9-27 (2014-05-10)<a class="anchor" aria-label="anchor" href="#mkin-09-27-2014-05-10"></a></h2> +<ul><li><p>Fork the GUI into a separate package <a href="https://github.com/jranke/gmkin" class="external-link">gmkin</a></p></li> <li><p>DESCRIPTION, NAMESPACE, TODO: Adapt and add copyright information</p></li> <li><p>Remove files belonging to the GUI</p></li> <li><p>Possibility to fit without parameter transformations, using bounds as implemented in FME</p></li> @@ -817,22 +564,16 @@ <li><p>Add a starter function for the GUI: <code>gmkin()</code></p></li> <li><p>Change the format of the workspace files of gmkin so they can be distributed and documented in the package</p></li> <li><p>Add gmkin workspace datasets FOCUS_2006_gmkin and FOCUS_2006_Z_gmkin</p></li> -</ul> -</div> - <div id="mkin-09-24-2013-11-06" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-24"> -<a href="#mkin-09-24-2013-11-06" class="anchor"></a>mkin 0.9-24 (2013-11-06)</h1> -<ul> -<li><p>Bugfix re-enabling the fixing of any combination of initial values for state variables</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-24" id="mkin-09-24-2013-11-06">mkin 0.9-24 (2013-11-06)<a class="anchor" aria-label="anchor" href="#mkin-09-24-2013-11-06"></a></h2> +<ul><li><p>Bugfix re-enabling the fixing of any combination of initial values for state variables</p></li> <li><p>Default values for kinetic rate constants are not all 0.1 any more but are “salted” with a small increment to avoid numeric artefacts with the eigenvalue based solutions</p></li> <li><p>Backtransform fixed ODE parameters for the summary</p></li> -</ul> -</div> - <div id="mkin-09-22-2013-10-26" class="section level1"> -<h1 class="page-header" data-toc-text="0.9-22"> -<a href="#mkin-09-22-2013-10-26" class="anchor"></a>mkin 0.9-22 (2013-10-26)</h1> -<ul> -<li><p>Get rid of the optimisation step in <code>mkinerrmin</code> - this was unnecessary. Thanks to KinGUII for the inspiration - actually this is equation 6-2 in FOCUS kinetics p. 91 that I had overlooked originally</p></li> +</ul></div> + <div class="section level2"> +<h2 class="page-header" data-toc-text="0.9-22" id="mkin-09-22-2013-10-26">mkin 0.9-22 (2013-10-26)<a class="anchor" aria-label="anchor" href="#mkin-09-22-2013-10-26"></a></h2> +<ul><li><p>Get rid of the optimisation step in <code>mkinerrmin</code> - this was unnecessary. Thanks to KinGUII for the inspiration - actually this is equation 6-2 in FOCUS kinetics p. 91 that I had overlooked originally</p></li> <li><p>Fix <code>plot.mkinfit</code> as it passed graphical arguments like main to the solver</p></li> <li><p>Do not use <code>plot=TRUE</code> in <code><a href="../reference/mkinfit.html">mkinfit()</a></code> example</p></li> <li><p>The first successful fits in the not so simple GUI</p></li> @@ -843,36 +584,31 @@ <li><p>Correct the output of the data in the case of manual weighting</p></li> <li><p>Implement IRLS assuming different variances for observed variables</p></li> <li><p>Do not use 0 values at time zero for chi2 error level calculations. This is the way it is done in KinGUII and it makes sense. It does impact the chi2 error levels in the output. Generally they seem to be lower for metabolites now, presumably because the mean of the observed values is higher</p></li> -</ul> -<p>For a detailed list of changes to the mkin source please consult the commit history on <a href="http://github.com/jranke/mkin" class="uri">http://github.com/jranke/mkin</a></p> +</ul><p>For a detailed list of changes to the mkin source please consult the commit history on <a href="http://github.com/jranke/mkin" class="external-link uri">http://github.com/jranke/mkin</a></p> </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/pkgdown.css b/docs/pkgdown.css index 1273238d..80ea5b83 100644 --- a/docs/pkgdown.css +++ b/docs/pkgdown.css @@ -56,8 +56,10 @@ img.icon { float: right; } -img { +/* Ensure in-page images don't run outside their container */ +.contents img { max-width: 100%; + height: auto; } /* Fix bug in bootstrap (only seen in firefox) */ @@ -78,11 +80,10 @@ dd { /* Section anchors ---------------------------------*/ a.anchor { - margin-left: -30px; - display:inline-block; - width: 30px; - height: 30px; - visibility: hidden; + display: none; + margin-left: 5px; + width: 20px; + height: 20px; background-image: url(./link.svg); background-repeat: no-repeat; @@ -90,17 +91,15 @@ a.anchor { background-position: center center; } -.hasAnchor:hover a.anchor { - visibility: visible; -} - -@media (max-width: 767px) { - .hasAnchor:hover a.anchor { - visibility: hidden; - } +h1:hover .anchor, +h2:hover .anchor, +h3:hover .anchor, +h4:hover .anchor, +h5:hover .anchor, +h6:hover .anchor { + display: inline-block; } - /* Fixes for fixed navbar --------------------------*/ .contents h1, .contents h2, .contents h3, .contents h4 { @@ -264,31 +263,26 @@ table { /* Syntax highlighting ---------------------------------------------------- */ -pre { - word-wrap: normal; - word-break: normal; - border: 1px solid #eee; -} - -pre, code { +pre, code, pre code { background-color: #f8f8f8; color: #333; } +pre, pre code { + white-space: pre-wrap; + word-break: break-all; + overflow-wrap: break-word; +} -pre code { - overflow: auto; - word-wrap: normal; - white-space: pre; +pre { + border: 1px solid #eee; } -pre .img { +pre .img, pre .r-plt { margin: 5px 0; } -pre .img img { +pre .img img, pre .r-plt img { background-color: #fff; - display: block; - height: auto; } code a, pre a { @@ -305,9 +299,8 @@ a.sourceLine:hover { .kw {color: #264D66;} /* keyword */ .co {color: #888888;} /* comment */ -.message { color: black; font-weight: bolder;} -.error { color: orange; font-weight: bolder;} -.warning { color: #6A0366; font-weight: bolder;} +.error {font-weight: bolder;} +.warning {font-weight: bolder;} /* Clipboard --------------------------*/ @@ -365,3 +358,27 @@ mark { content: ""; } } + +/* Section anchors --------------------------------- + Added in pandoc 2.11: https://github.com/jgm/pandoc-templates/commit/9904bf71 +*/ + +div.csl-bib-body { } +div.csl-entry { + clear: both; +} +.hanging-indent div.csl-entry { + margin-left:2em; + text-indent:-2em; +} +div.csl-left-margin { + min-width:2em; + float:left; +} +div.csl-right-inline { + margin-left:2em; + padding-left:1em; +} +div.csl-indent { + margin-left: 2em; +} diff --git a/docs/pkgdown.js b/docs/pkgdown.js index 7e7048fa..6f0eee40 100644 --- a/docs/pkgdown.js +++ b/docs/pkgdown.js @@ -80,7 +80,7 @@ $(document).ready(function() { var copyButton = "<button type='button' class='btn btn-primary btn-copy-ex' type = 'submit' title='Copy to clipboard' aria-label='Copy to clipboard' data-toggle='tooltip' data-placement='left auto' data-trigger='hover' data-clipboard-copy><i class='fa fa-copy'></i></button>"; - $(".examples, div.sourceCode").addClass("hasCopyButton"); + $("div.sourceCode").addClass("hasCopyButton"); // Insert copy buttons: $(copyButton).prependTo(".hasCopyButton"); @@ -91,7 +91,7 @@ // Initialize clipboard: var clipboardBtnCopies = new ClipboardJS('[data-clipboard-copy]', { text: function(trigger) { - return trigger.parentNode.textContent; + return trigger.parentNode.textContent.replace(/\n#>[^\n]*/g, ""); } }); diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index c655c059..48a22c2f 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -1,16 +1,17 @@ pandoc: 2.9.2.1 -pkgdown: 1.6.1 +pkgdown: 2.0.2 pkgdown_sha: ~ articles: FOCUS_D: FOCUS_D.html FOCUS_L: FOCUS_L.html mkin: mkin.html twa: twa.html - web_only/FOCUS_Z: FOCUS_Z.html - web_only/NAFTA_examples: NAFTA_examples.html - web_only/benchmarks: benchmarks.html - web_only/compiled_models: compiled_models.html -last_built: 2021-10-01T11:50Z + FOCUS_Z: web_only/FOCUS_Z.html + NAFTA_examples: web_only/NAFTA_examples.html + benchmarks: web_only/benchmarks.html + compiled_models: web_only/compiled_models.html + dimethenamid_2018: web_only/dimethenamid_2018.html +last_built: 2022-03-02T16:55Z urls: reference: https://pkgdown.jrwb.de/mkin/reference article: https://pkgdown.jrwb.de/mkin/articles diff --git a/docs/reference/AIC.mmkin.html b/docs/reference/AIC.mmkin.html index fbc90802..35becede 100644 --- a/docs/reference/AIC.mmkin.html +++ b/docs/reference/AIC.mmkin.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> 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data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ same dataset." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ same dataset." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ same dataset." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ same dataset." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Calculate the AIC for a column of an mmkin object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/AIC.mmkin.R'><code>R/AIC.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/AIC.mmkin.R" class="external-link"><code>R/AIC.mmkin.R</code></a></small> <div class="hidden name"><code>AIC.mmkin.Rd</code></div> </div> @@ -149,102 +88,103 @@ same dataset." /> same dataset.</p> </div> - <pre class="usage"><span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span>, k <span class='op'>=</span> <span class='fl'>2</span><span class='op'>)</span> - -<span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>BIC</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An object of class <code><a href='mmkin.html'>mmkin</a></code>, containing only one -column.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>For compatibility with the generic method</p></td> - </tr> - <tr> - <th>k</th> - <td><p>As in the generic method</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span>, k <span class="op">=</span> <span class="fl">2</span><span class="op">)</span> + +<span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An object of class <code><a href="mmkin.html">mmkin</a></code>, containing only one +column.</p></dd> +<dt>...</dt> +<dd><p>For compatibility with the generic method</p></dd> +<dt>k</dt> +<dd><p>As in the generic method</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>As in the generic method (a numeric value for single fits, or a dataframe if there are several fits in the column).</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='co'># skip, as it takes > 10 s on winbuilder</span> - <span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"FOCUS A"</span> <span class='op'>=</span> <span class='va'>FOCUS_2006_A</span>, - <span class='st'>"FOCUS C"</span> <span class='op'>=</span> <span class='va'>FOCUS_2006_C</span><span class='op'>)</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='co'># We get a warning because the FOMC model does not converge for the</span> - <span class='co'># FOCUS A dataset, as it is well described by SFO</span> - - <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span><span class='st'>"SFO"</span>, <span class='st'>"FOCUS A"</span><span class='op'>]</span><span class='op'>)</span> <span class='co'># We get a single number for a single fit</span> -</div><div class='output co'>#> [1] 55.28197</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[[</span><span class='st'>"SFO"</span>, <span class='st'>"FOCUS A"</span><span class='op'>]</span><span class='op'>]</span><span class='op'>)</span> <span class='co'># or when extracting an mkinfit object</span> -</div><div class='output co'>#> [1] 55.28197</div><div class='input'> - <span class='co'># For FOCUS A, the models fit almost equally well, so the higher the number</span> - <span class='co'># of parameters, the higher (worse) the AIC</span> - <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='st'>"FOCUS A"</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> df AIC -#> SFO 3 55.28197 -#> FOMC 4 57.28222 -#> DFOP 5 59.28197</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='st'>"FOCUS A"</span><span class='op'>]</span>, k <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span> <span class='co'># If we do not penalize additional parameters, we get nearly the same</span> -</div><div class='output co'>#> df AIC -#> SFO 3 49.28197 -#> FOMC 4 49.28222 -#> DFOP 5 49.28197</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>BIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='st'>"FOCUS A"</span><span class='op'>]</span><span class='op'>)</span> <span class='co'># Comparing the BIC gives a very similar picture</span> -</div><div class='output co'>#> df BIC -#> SFO 3 55.52030 -#> FOMC 4 57.59999 -#> DFOP 5 59.67918</div><div class='input'> - <span class='co'># For FOCUS C, the more complex models fit better</span> - <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='st'>"FOCUS C"</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> df AIC -#> SFO 3 59.29336 -#> FOMC 4 44.68652 -#> DFOP 5 29.02372</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>BIC</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='st'>"FOCUS C"</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> df BIC -#> SFO 3 59.88504 -#> FOMC 4 45.47542 -#> DFOP 5 30.00984</div><div class='input'> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="co"># skip, as it takes > 10 s on winbuilder</span></span> +<span class="r-in"> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span> +<span class="r-in"> <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="co"># We get a warning because the FOMC model does not converge for the</span></span> +<span class="r-in"> <span class="co"># FOCUS A dataset, as it is well described by SFO</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span> <span class="co"># We get a single number for a single fit</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 55.28197</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> <span class="co"># or when extracting an mkinfit object</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 55.28197</span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># For FOCUS A, the models fit almost equally well, so the higher the number</span></span> +<span class="r-in"> <span class="co"># of parameters, the higher (worse) the AIC</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 3 55.28197</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC 4 57.28222</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 5 59.28197</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span>, k <span class="op">=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># If we do not penalize additional parameters, we get nearly the same</span></span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 3 49.28197</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC 4 49.28222</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 5 49.28197</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span> <span class="co"># Comparing the BIC gives a very similar picture</span></span> +<span class="r-out co"><span class="r-pr">#></span> df BIC</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 3 55.52030</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC 4 57.59999</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 5 59.67918</span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># For FOCUS C, the more complex models fit better</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 3 59.29336</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC 4 44.68652</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 5 29.02372</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> df BIC</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 3 59.88504</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC 4 45.47542</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 5 30.00984</span> +<span class="r-in"> </span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/CAKE_export.html b/docs/reference/CAKE_export.html index 05cd04a7..d36f5ed9 100644 --- a/docs/reference/CAKE_export.html +++ b/docs/reference/CAKE_export.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Export a list of datasets format to a CAKE study file — CAKE_export • 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property="og:description" content="In addition to the datasets, the pathways in the degradation model can be +specified as well."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ specified as well." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ specified as well." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ specified as well." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ specified as well." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Export a list of datasets format to a CAKE study file</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/CAKE_export.R'><code>R/CAKE_export.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/CAKE_export.R" class="external-link"><code>R/CAKE_export.R</code></a></small> <div class="hidden name"><code>CAKE_export.Rd</code></div> </div> @@ -149,116 +88,88 @@ specified as well." /> specified as well.</p> </div> - <pre class="usage"><span class='fu'>CAKE_export</span><span class='op'>(</span> - <span class='va'>ds</span>, - map <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='st'>"Parent"</span><span class='op'>)</span>, - links <span class='op'>=</span> <span class='cn'>NA</span>, - filename <span class='op'>=</span> <span class='st'>"CAKE_export.csf"</span>, - path <span class='op'>=</span> <span class='st'>"."</span>, - overwrite <span class='op'>=</span> <span class='cn'>FALSE</span>, - study <span class='op'>=</span> <span class='st'>"Codlemone aerobic soil degradation"</span>, - description <span class='op'>=</span> <span class='st'>""</span>, - time_unit <span class='op'>=</span> <span class='st'>"days"</span>, - res_unit <span class='op'>=</span> <span class='st'>"% AR"</span>, - comment <span class='op'>=</span> <span class='st'>"Created using mkin::CAKE_export"</span>, - date <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Sys.time.html'>Sys.Date</a></span><span class='op'>(</span><span class='op'>)</span>, - optimiser <span class='op'>=</span> <span class='st'>"IRLS"</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">CAKE_export</span><span class="op">(</span> + <span class="va">ds</span>, + map <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="st">"Parent"</span><span class="op">)</span>, + links <span class="op">=</span> <span class="cn">NA</span>, + filename <span class="op">=</span> <span class="st">"CAKE_export.csf"</span>, + path <span class="op">=</span> <span class="st">"."</span>, + overwrite <span class="op">=</span> <span class="cn">FALSE</span>, + study <span class="op">=</span> <span class="st">"Codlemone aerobic soil degradation"</span>, + description <span class="op">=</span> <span class="st">""</span>, + time_unit <span class="op">=</span> <span class="st">"days"</span>, + res_unit <span class="op">=</span> <span class="st">"% AR"</span>, + comment <span class="op">=</span> <span class="st">"Created using mkin::CAKE_export"</span>, + date <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Sys.time.html" class="external-link">Sys.Date</a></span><span class="op">(</span><span class="op">)</span>, + optimiser <span class="op">=</span> <span class="st">"IRLS"</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>ds</th> - <td><p>A named list of datasets in long format as compatible with -<code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>map</th> - <td><p>A character vector with CAKE compartment names (Parent, A1, ...), -named with the names used in the list of datasets.</p></td> - </tr> - <tr> - <th>links</th> - <td><p>An optional character vector of target compartments, named with + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>ds</dt> +<dd><p>A named list of datasets in long format as compatible with +<code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>map</dt> +<dd><p>A character vector with CAKE compartment names (Parent, A1, ...), +named with the names used in the list of datasets.</p></dd> +<dt>links</dt> +<dd><p>An optional character vector of target compartments, named with the names of the source compartments. In order to make this easier, the -names are used as in the datasets supplied.</p></td> - </tr> - <tr> - <th>filename</th> - <td><p>Where to write the result. Should end in .csf in order to be -compatible with CAKE.</p></td> - </tr> - <tr> - <th>path</th> - <td><p>An optional path to the output file.</p></td> - </tr> - <tr> - <th>overwrite</th> - <td><p>If TRUE, existing files are overwritten.</p></td> - </tr> - <tr> - <th>study</th> - <td><p>The name of the study.</p></td> - </tr> - <tr> - <th>description</th> - <td><p>An optional description.</p></td> - </tr> - <tr> - <th>time_unit</th> - <td><p>The time unit for the residue data.</p></td> - </tr> - <tr> - <th>res_unit</th> - <td><p>The unit used for the residues.</p></td> - </tr> - <tr> - <th>comment</th> - <td><p>An optional comment.</p></td> - </tr> - <tr> - <th>date</th> - <td><p>The date of file creation.</p></td> - </tr> - <tr> - <th>optimiser</th> - <td><p>Can be OLS or IRLS.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +names are used as in the datasets supplied.</p></dd> +<dt>filename</dt> +<dd><p>Where to write the result. Should end in .csf in order to be +compatible with CAKE.</p></dd> +<dt>path</dt> +<dd><p>An optional path to the output file.</p></dd> +<dt>overwrite</dt> +<dd><p>If TRUE, existing files are overwritten.</p></dd> +<dt>study</dt> +<dd><p>The name of the study.</p></dd> +<dt>description</dt> +<dd><p>An optional description.</p></dd> +<dt>time_unit</dt> +<dd><p>The time unit for the residue data.</p></dd> +<dt>res_unit</dt> +<dd><p>The unit used for the residues.</p></dd> +<dt>comment</dt> +<dd><p>An optional comment.</p></dd> +<dt>date</dt> +<dd><p>The date of file creation.</p></dd> +<dt>optimiser</dt> +<dd><p>Can be OLS or IRLS.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/D24_2014.html b/docs/reference/D24_2014.html index c59bfad6..b18e6285 100644 --- a/docs/reference/D24_2014.html +++ b/docs/reference/D24_2014.html @@ -1,72 +1,17 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 — D24_2014 • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - -<!-- Font Awesome icons --> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous" /> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" /> - -<!-- clipboard.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script> - -<!-- headroom.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script> - -<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 — D24_2014" /> -<meta property="og:description" content="The five datasets were extracted from the active substance evaluation dossier +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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Kinetic evaluations shown for these datasets are intended to illustrate and advance kinetic modelling. The fact that these data and some results are shown here does not imply a license to use them in the context of pesticide registrations, as the use of the data may be -constrained by data protection regulations." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +constrained by data protection regulations."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -77,13 +22,12 @@ constrained by data protection regulations." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -92,8 +36,7 @@ constrained by data protection regulations." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -103,6 +46,9 @@ constrained by data protection regulations." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -117,34 +63,27 @@ constrained by data protection regulations." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/D24_2014.R'><code>R/D24_2014.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/D24_2014.R" class="external-link"><code>R/D24_2014.R</code></a></small> <div class="hidden name"><code>D24_2014.Rd</code></div> </div> @@ -157,20 +96,23 @@ context of pesticide registrations, as the use of the data may be constrained by data protection regulations.</p> </div> - <pre class="usage"><span class='va'>D24_2014</span></pre> - - - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> - - <p>An <a href='mkindsg.html'>mkindsg</a> object grouping five datasets</p> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">D24_2014</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>An <a href="mkindsg.html">mkindsg</a> object grouping five datasets</p> + </div> + <div id="source"> + <h2>Source</h2> <p>Hellenic Ministry of Rural Development and Agriculture (2014) Final addendum to the Renewal Assessment Report - public version - 2,4-D Volume 3 Annex B.8 Fate and behaviour in the environment -<a href='http://registerofquestions.efsa.europa.eu/roqFrontend/outputLoader?output=ON-3812'>http://registerofquestions.efsa.europa.eu/roqFrontend/outputLoader?output=ON-3812</a></p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - +<a href="http://registerofquestions.efsa.europa.eu/roqFrontend/outputLoader?output=ON-3812" class="external-link">http://registerofquestions.efsa.europa.eu/roqFrontend/outputLoader?output=ON-3812</a></p> + </div> + <div id="details"> + <h2>Details</h2> <p>Data for the first dataset are from p. 685. Data for the other four datasets were used in the preprocessed versions given in the kinetics section (p. 761ff.), with the exception of residues smaller than 1 for DCP @@ -178,114 +120,119 @@ in the soil from Site I2, where the values given on p. 694 were used.</p> <p>The R code used to create this data object is installed with this package in the 'dataset_generation' directory. In the code, page numbers are given for specific pieces of information in the comments.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>D24_2014</span><span class='op'>)</span> -</div><div class='output co'>#> <mkindsg> holding 5 mkinds objects -#> Title $title: Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 -#> Occurrence of observed compounds $observed_n: -#> D24 DCP DCA -#> 5 4 4 -#> Time normalisation factors $f_time_norm: -#> [1] 1.6062378 0.7118732 0.7156063 0.7156063 0.8977124 -#> Meta information $meta: -#> study usda_soil_type study_moisture_ref_type -#> Mississippi Cohen 1991 Silt loam <NA> -#> Fayette Liu and Adelfinskaya 2011 Silt loam pF1 -#> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1 -#> Site E1 Liu and Adelfinskaya 2011 Loam pF1 -#> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1 -#> rel_moisture temperature -#> Mississippi NA 25 -#> Fayette 0.5 20 -#> RefSol 03-G 0.5 20 -#> Site E1 0.5 20 -#> Site I2 0.5 20</div><div class='input'><span class='co'># \dontrun{</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>D24_2014</span><span class='op'>$</span><span class='va'>ds</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span>, data <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <mkinds> with $title: Mississippi -#> Observed compounds $observed: D24 -#> Sampling times $sampling_times: -#> 0, 2, 4, 7, 15, 24, 35, 56, 71, 114, 183, 273, 365 -#> With a maximum of 1 replicates -#> time D24 -#> 1 0 96.8 -#> 2 2 81.0 -#> 3 4 81.7 -#> 4 7 88.2 -#> 5 15 66.3 -#> 6 24 72.9 -#> 7 35 62.6 -#> 8 56 54.6 -#> 9 71 35.2 -#> 10 114 18.0 -#> 11 183 11.3 -#> 12 273 9.9 -#> 13 365 6.3</div><div class='input'><span class='va'>m_D24</span> <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>D24 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"DCP"</span><span class='op'>)</span>, - DCP <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"DCA"</span><span class='op'>)</span>, - DCA <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>m_D24</span><span class='op'>)</span> -</div><div class='output co'>#> <mkinmod> model generated with -#> Use of formation fractions $use_of_ff: max -#> Specification $spec: -#> $D24 -#> $type: SFO; $to: DCP; $sink: TRUE -#> $DCP -#> $type: SFO; $to: DCA; $sink: TRUE -#> $DCA -#> $type: SFO; $sink: TRUE -#> Coefficient matrix $coefmat available -#> Compiled model $cf available -#> Differential equations: -#> d_D24/dt = - k_D24 * D24 -#> d_DCP/dt = + f_D24_to_DCP * k_D24 * D24 - k_DCP * DCP -#> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</div><div class='input'><span class='va'>m_D24_2</span> <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>D24 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='st'>"DCP"</span><span class='op'>)</span>, - DCP <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"DCA"</span><span class='op'>)</span>, - DCA <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>m_D24_2</span><span class='op'>)</span> -</div><div class='output co'>#> <mkinmod> model generated with -#> Use of formation fractions $use_of_ff: max -#> Specification $spec: -#> $D24 -#> $type: DFOP; $to: DCP; $sink: TRUE -#> $DCP -#> $type: SFO; $to: DCA; $sink: TRUE -#> $DCA -#> $type: SFO; $sink: TRUE -#> Compiled model $cf available -#> Differential equations: -#> d_D24/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -#> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -#> * D24 -#> d_DCP/dt = + f_D24_to_DCP * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * -#> exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 -#> * time))) * D24 - k_DCP * DCP -#> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">D24_2014</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> +<span class="r-out co"><span class="r-pr">#></span> Title $title: Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 </span> +<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> +<span class="r-out co"><span class="r-pr">#></span> D24 DCP DCA </span> +<span class="r-out co"><span class="r-pr">#></span> 5 4 4 </span> +<span class="r-out co"><span class="r-pr">#></span> Time normalisation factors $f_time_norm:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1.6062378 0.7118732 0.7156063 0.7156063 0.8977124</span> +<span class="r-out co"><span class="r-pr">#></span> Meta information $meta:</span> +<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type</span> +<span class="r-out co"><span class="r-pr">#></span> Mississippi Cohen 1991 Silt loam <NA></span> +<span class="r-out co"><span class="r-pr">#></span> Fayette Liu and Adelfinskaya 2011 Silt loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> Site E1 Liu and Adelfinskaya 2011 Loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1</span> +<span class="r-out co"><span class="r-pr">#></span> rel_moisture temperature</span> +<span class="r-out co"><span class="r-pr">#></span> Mississippi NA 25</span> +<span class="r-out co"><span class="r-pr">#></span> Fayette 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> Site E1 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> Site I2 0.5 20</span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">D24_2014</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Mississippi </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: D24 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 2, 4, 7, 15, 24, 35, 56, 71, 114, 183, 273, 365 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 1 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> time D24</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 96.8</span> +<span class="r-out co"><span class="r-pr">#></span> 2 2 81.0</span> +<span class="r-out co"><span class="r-pr">#></span> 3 4 81.7</span> +<span class="r-out co"><span class="r-pr">#></span> 4 7 88.2</span> +<span class="r-out co"><span class="r-pr">#></span> 5 15 66.3</span> +<span class="r-out co"><span class="r-pr">#></span> 6 24 72.9</span> +<span class="r-out co"><span class="r-pr">#></span> 7 35 62.6</span> +<span class="r-out co"><span class="r-pr">#></span> 8 56 54.6</span> +<span class="r-out co"><span class="r-pr">#></span> 9 71 35.2</span> +<span class="r-out co"><span class="r-pr">#></span> 10 114 18.0</span> +<span class="r-out co"><span class="r-pr">#></span> 11 183 11.3</span> +<span class="r-out co"><span class="r-pr">#></span> 12 273 9.9</span> +<span class="r-out co"><span class="r-pr">#></span> 13 365 6.3</span> +<span class="r-in"><span class="va">m_D24</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>D24 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCP"</span><span class="op">)</span>,</span> +<span class="r-in"> DCP <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCA"</span><span class="op">)</span>,</span> +<span class="r-in"> DCA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">m_D24</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> +<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> +<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> +<span class="r-out co"><span class="r-pr">#></span> $D24</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCP; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> $DCP</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCA; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> $DCA</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> Coefficient matrix $coefmat available</span> +<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> +<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_D24/dt = - k_D24 * D24</span> +<span class="r-out co"><span class="r-pr">#></span> d_DCP/dt = + f_D24_to_DCP * k_D24 * D24 - k_DCP * DCP</span> +<span class="r-out co"><span class="r-pr">#></span> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</span> +<span class="r-in"><span class="va">m_D24_2</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>D24 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"DCP"</span><span class="op">)</span>,</span> +<span class="r-in"> DCP <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCA"</span><span class="op">)</span>,</span> +<span class="r-in"> DCA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">m_D24_2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> +<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> +<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> +<span class="r-out co"><span class="r-pr">#></span> $D24</span> +<span class="r-out co"><span class="r-pr">#></span> $type: DFOP; $to: DCP; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> $DCP</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCA; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> $DCA</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> +<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_D24/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * D24</span> +<span class="r-out co"><span class="r-pr">#></span> d_DCP/dt = + f_D24_to_DCP * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2</span> +<span class="r-out co"><span class="r-pr">#></span> * time))) * D24 - k_DCP * DCP</span> +<span class="r-out co"><span class="r-pr">#></span> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + 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data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ two exponential decline functions." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ two exponential decline functions." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ two exponential decline functions." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ two exponential decline functions." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Double First-Order in Parallel kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>DFOP.solution.Rd</code></div> </div> @@ -149,89 +88,81 @@ two exponential decline functions." /> two exponential decline functions.</p> </div> - <pre class="usage"><span class='fu'>DFOP.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>g</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>k1</th> - <td><p>First kinetic constant.</p></td> - </tr> - <tr> - <th>k2</th> - <td><p>Second kinetic constant.</p></td> - </tr> - <tr> - <th>g</th> - <td><p>Fraction of the starting value declining according to the first -kinetic constant.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>k1</dt> +<dd><p>First kinetic constant.</p></dd> +<dt>k2</dt> +<dd><p>Second kinetic constant.</p></dd> +<dt>g</dt> +<dd><p>Fraction of the starting value declining according to the first +kinetic constant.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>DFOP.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>5</span>, <span class='fl'>0.5</span>, <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>4</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>,<span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='DFOP.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">5</span>, <span class="fl">0.5</span>, <span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">4</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="DFOP.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> 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data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Subsetting method for mmkin objects</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mmkin.R'><code>R/mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mmkin.R" class="external-link"><code>R/mmkin.R</code></a></small> <div class="hidden name"><code>Extract.mmkin.Rd</code></div> </div> @@ -147,122 +86,116 @@ <p>Subsetting method for mmkin objects</p> </div> - <pre class="usage"># S3 method for mmkin -[(x, i, j, ..., drop = FALSE)</pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An <code><a href='mmkin.html'>mmkin</a> object</code></p></td> - </tr> - <tr> - <th>i</th> - <td><p>Row index selecting the fits for specific models</p></td> - </tr> - <tr> - <th>j</th> - <td><p>Column index selecting the fits to specific datasets</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used, only there to satisfy the generic method definition</p></td> - </tr> - <tr> - <th>drop</th> - <td><p>If FALSE, the method always returns an mmkin object, otherwise -either a list of mkinfit objects or a single mkinfit object.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>An object of class <code><a href='mmkin.html'>mmkin</a></code>.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre><code># S3 method for mmkin +[(x, i, j, ..., drop = FALSE)</code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An <code><a href="mmkin.html">mmkin</a> object</code></p></dd> +<dt>i</dt> +<dd><p>Row index selecting the fits for specific models</p></dd> +<dt>j</dt> +<dd><p>Column index selecting the fits to specific datasets</p></dd> +<dt>...</dt> +<dd><p>Not used, only there to satisfy the generic method definition</p></dd> +<dt>drop</dt> +<dd><p>If FALSE, the method always returns an mmkin object, otherwise +either a list of mkinfit objects or a single mkinfit object.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An object of class <code><a href="mmkin.html">mmkin</a></code>.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='co'># Only use one core, to pass R CMD check --as-cran</span> - <span class='va'>fits</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>B <span class='op'>=</span> <span class='va'>FOCUS_2006_B</span>, C <span class='op'>=</span> <span class='va'>FOCUS_2006_C</span><span class='op'>)</span>, - cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>fits</span><span class='op'>[</span><span class='st'>"FOMC"</span>, <span class='op'>]</span> -</div><div class='output co'>#> <mmkin> object -#> Status of individual fits: -#> -#> dataset -#> model B C -#> FOMC OK OK -#> -#> OK: No warnings</div><div class='input'> <span class='va'>fits</span><span class='op'>[</span>, <span class='st'>"B"</span><span class='op'>]</span> -</div><div class='output co'>#> <mmkin> object -#> Status of individual fits: -#> -#> dataset -#> model B -#> SFO OK -#> FOMC OK -#> -#> OK: No warnings</div><div class='input'> <span class='va'>fits</span><span class='op'>[</span><span class='st'>"SFO"</span>, <span class='st'>"B"</span><span class='op'>]</span> -</div><div class='output co'>#> <mmkin> object -#> Status of individual fits: -#> -#> dataset -#> model B -#> SFO OK -#> -#> OK: No warnings</div><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/utils/head.html'>head</a></span><span class='op'>(</span> - <span class='co'># This extracts an mkinfit object with lots of components</span> - <span class='va'>fits</span><span class='op'>[[</span><span class='st'>"FOMC"</span>, <span class='st'>"B"</span><span class='op'>]</span><span class='op'>]</span> - <span class='op'>)</span> -</div><div class='output co'>#> $par -#> parent_0 log_alpha log_beta sigma -#> 99.666192 2.549850 5.050586 1.890202 -#> -#> $objective -#> [1] 28.58291 -#> -#> $convergence -#> [1] 0 -#> -#> $iterations -#> [1] 21 -#> -#> $evaluations -#> function gradient -#> 25 78 -#> -#> $message -#> [1] "both X-convergence and relative convergence (5)" -#> </div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="co"># Only use one core, to pass R CMD check --as-cran</span></span> +<span class="r-in"> <span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>B <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, C <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span> +<span class="r-in"> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> +<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> dataset</span> +<span class="r-out co"><span class="r-pr">#></span> model B C </span> +<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> +<span class="r-in"> <span class="va">fits</span><span class="op">[</span>, <span class="st">"B"</span><span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> +<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> dataset</span> +<span class="r-out co"><span class="r-pr">#></span> model B </span> +<span class="r-out co"><span class="r-pr">#></span> SFO OK</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC OK</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> +<span class="r-in"> <span class="va">fits</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="st">"B"</span><span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> +<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> dataset</span> +<span class="r-out co"><span class="r-pr">#></span> model B </span> +<span class="r-out co"><span class="r-pr">#></span> SFO OK</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="co"># This extracts an mkinfit object with lots of components</span></span> +<span class="r-in"> <span class="va">fits</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="st">"B"</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"> <span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $par</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_alpha log_beta sigma </span> +<span class="r-out co"><span class="r-pr">#></span> 99.666192 2.549850 5.050586 1.890202 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $objective</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 28.58291</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $convergence</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $iterations</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 21</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $evaluations</span> +<span class="r-out co"><span class="r-pr">#></span> function gradient </span> +<span class="r-out co"><span class="r-pr">#></span> 25 78 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $message</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "both X-convergence and relative convergence (5)"</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs 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href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Results of fitting the DFOP model to Datasets A to B of FOCUS (2006) — FOCUS_2006_DFOP_ref_A_to_B"><meta property="og:description" content="A table with the fitted parameters and the resulting DT50 and DT90 values generated with different software packages. Taken directly from FOCUS (2006). The results from fitting the data with the Topfit software was removed, as the initial concentration of the parent compound was fixed to a value of 100 -in this fit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +in this fit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ in this fit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ in this fit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ in this fit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,30 +62,23 @@ in this fit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)</h1> @@ -155,59 +94,73 @@ the initial concentration of the parent compound was fixed to a value of 100 in this fit.</p> </div> - <pre class="usage"><span class='va'>FOCUS_2006_DFOP_ref_A_to_B</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">FOCUS_2006_DFOP_ref_A_to_B</span></code></pre></div> + </div> + + <div id="format"> + <h2>Format</h2> + <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> +<dd><p>a factor giving the name of the software package</p></dd> + <dt><code>M0</code></dt> +<dd><p>The fitted initial concentration of the parent compound</p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>f</code></dt> +<dd><p>The fitted f parameter</p></dd> - <p>A data frame containing the following variables.</p><dl> - <dt><code>package</code></dt><dd><p>a factor giving the name of the software package</p></dd> - <dt><code>M0</code></dt><dd><p>The fitted initial concentration of the parent compound</p></dd> - <dt><code>f</code></dt><dd><p>The fitted f parameter</p></dd> - <dt><code>k1</code></dt><dd><p>The fitted k1 parameter</p></dd> - <dt><code>k2</code></dt><dd><p>The fitted k2 parameter</p></dd> - <dt><code>DT50</code></dt><dd><p>The resulting half-life of the parent compound</p></dd> - <dt><code>DT90</code></dt><dd><p>The resulting DT90 of the parent compound</p></dd> - <dt><code>dataset</code></dt><dd><p>The FOCUS dataset that was used</p></dd> - -</dl> + <dt><code>k1</code></dt> +<dd><p>The fitted k1 parameter</p></dd> + + <dt><code>k2</code></dt> +<dd><p>The fitted k2 parameter</p></dd> + + <dt><code>DT50</code></dt> +<dd><p>The resulting half-life of the parent compound</p></dd> + + <dt><code>DT90</code></dt> +<dd><p>The resulting DT90 of the parent compound</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>dataset</code></dt> +<dd><p>The FOCUS dataset that was used</p></dd> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and + +</dl></div> + <div id="source"> + <h2>Source</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/utils/data.html'>data</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_DFOP_ref_A_to_B</span><span class='op'>)</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_DFOP_ref_A_to_B</span><span class="op">)</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/FOCUS_2006_FOMC_ref_A_to_F.html b/docs/reference/FOCUS_2006_FOMC_ref_A_to_F.html index cfb60536..c332446f 100644 --- a/docs/reference/FOCUS_2006_FOMC_ref_A_to_F.html +++ b/docs/reference/FOCUS_2006_FOMC_ref_A_to_F.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006) — FOCUS_2006_FOMC_ref_A_to_F • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - 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Taken directly from FOCUS (2006). The results from fitting the data with the Topfit software was removed, as the initial concentration of the parent compound was fixed to a value of 100 -in this fit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +in this fit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ in this fit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ in this fit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ in this fit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,30 +62,23 @@ in this fit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)</h1> @@ -155,58 +94,70 @@ the initial concentration of the parent compound was fixed to a value of 100 in this fit.</p> </div> - <pre class="usage"><span class='va'>FOCUS_2006_FOMC_ref_A_to_F</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">FOCUS_2006_FOMC_ref_A_to_F</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> +<dd><p>a factor giving the name of the software package</p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>M0</code></dt> +<dd><p>The fitted initial concentration of the parent compound</p></dd> - <p>A data frame containing the following variables.</p><dl> - <dt><code>package</code></dt><dd><p>a factor giving the name of the software package</p></dd> - <dt><code>M0</code></dt><dd><p>The fitted initial concentration of the parent compound</p></dd> - <dt><code>alpha</code></dt><dd><p>The fitted alpha parameter</p></dd> - <dt><code>beta</code></dt><dd><p>The fitted beta parameter</p></dd> - <dt><code>DT50</code></dt><dd><p>The resulting half-life of the parent compound</p></dd> - <dt><code>DT90</code></dt><dd><p>The resulting DT90 of the parent compound</p></dd> - <dt><code>dataset</code></dt><dd><p>The FOCUS dataset that was used</p></dd> - -</dl> + <dt><code>alpha</code></dt> +<dd><p>The fitted alpha parameter</p></dd> + + <dt><code>beta</code></dt> +<dd><p>The fitted beta parameter</p></dd> + + <dt><code>DT50</code></dt> +<dd><p>The resulting half-life of the parent compound</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>DT90</code></dt> +<dd><p>The resulting DT90 of the parent compound</p></dd> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and + <dt><code>dataset</code></dt> +<dd><p>The FOCUS dataset that was used</p></dd> + + +</dl></div> + <div id="source"> + <h2>Source</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/utils/data.html'>data</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_FOMC_ref_A_to_F</span><span class='op'>)</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_FOMC_ref_A_to_F</span><span class="op">)</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/FOCUS_2006_HS_ref_A_to_F.html b/docs/reference/FOCUS_2006_HS_ref_A_to_F.html index c90bcdbb..151925d9 100644 --- a/docs/reference/FOCUS_2006_HS_ref_A_to_F.html +++ b/docs/reference/FOCUS_2006_HS_ref_A_to_F.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Results of fitting the HS model to Datasets A to F of FOCUS (2006) — FOCUS_2006_HS_ref_A_to_F • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - 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Taken directly from FOCUS (2006). The results from fitting the data with the Topfit software was removed, as the initial concentration of the parent compound was fixed to a value of 100 -in this fit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +in this fit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ in this fit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ in this fit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ in this fit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,30 +62,23 @@ in this fit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Results of fitting the HS model to Datasets A to F of FOCUS (2006)</h1> @@ -155,59 +94,73 @@ the initial concentration of the parent compound was fixed to a value of 100 in this fit.</p> </div> - <pre class="usage"><span class='va'>FOCUS_2006_HS_ref_A_to_F</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">FOCUS_2006_HS_ref_A_to_F</span></code></pre></div> + </div> + + <div id="format"> + <h2>Format</h2> + <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> +<dd><p>a factor giving the name of the software package</p></dd> + <dt><code>M0</code></dt> +<dd><p>The fitted initial concentration of the parent compound</p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>tb</code></dt> +<dd><p>The fitted tb parameter</p></dd> - <p>A data frame containing the following variables.</p><dl> - <dt><code>package</code></dt><dd><p>a factor giving the name of the software package</p></dd> - <dt><code>M0</code></dt><dd><p>The fitted initial concentration of the parent compound</p></dd> - <dt><code>tb</code></dt><dd><p>The fitted tb parameter</p></dd> - <dt><code>k1</code></dt><dd><p>The fitted k1 parameter</p></dd> - <dt><code>k2</code></dt><dd><p>The fitted k2 parameter</p></dd> - <dt><code>DT50</code></dt><dd><p>The resulting half-life of the parent compound</p></dd> - <dt><code>DT90</code></dt><dd><p>The resulting DT90 of the parent compound</p></dd> - <dt><code>dataset</code></dt><dd><p>The FOCUS dataset that was used</p></dd> - -</dl> + <dt><code>k1</code></dt> +<dd><p>The fitted k1 parameter</p></dd> + + <dt><code>k2</code></dt> +<dd><p>The fitted k2 parameter</p></dd> + + <dt><code>DT50</code></dt> +<dd><p>The resulting half-life of the parent compound</p></dd> + + <dt><code>DT90</code></dt> +<dd><p>The resulting DT90 of the parent compound</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>dataset</code></dt> +<dd><p>The FOCUS dataset that was used</p></dd> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and + +</dl></div> + <div id="source"> + <h2>Source</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/utils/data.html'>data</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_HS_ref_A_to_F</span><span class='op'>)</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_HS_ref_A_to_F</span><span class="op">)</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/FOCUS_2006_SFO_ref_A_to_F.html b/docs/reference/FOCUS_2006_SFO_ref_A_to_F.html index 7b2747dc..f8e368cf 100644 --- a/docs/reference/FOCUS_2006_SFO_ref_A_to_F.html +++ b/docs/reference/FOCUS_2006_SFO_ref_A_to_F.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Results of fitting the SFO model to Datasets A to F of FOCUS (2006) — FOCUS_2006_SFO_ref_A_to_F • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - 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-<!-- headroom.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script> - -<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Results of fitting the SFO model to Datasets A to F of FOCUS (2006) — FOCUS_2006_SFO_ref_A_to_F" /> -<meta property="og:description" content="A table with the fitted parameters and the resulting DT50 and DT90 values +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Results of fitting the SFO model to Datasets A to F of FOCUS (2006) — FOCUS_2006_SFO_ref_A_to_F • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Results of fitting the SFO model to Datasets A to F of FOCUS (2006) — FOCUS_2006_SFO_ref_A_to_F"><meta property="og:description" content="A table with the fitted parameters and the resulting DT50 and DT90 values generated with different software packages. Taken directly from FOCUS (2006). The results from fitting the data with the Topfit software was removed, as the initial concentration of the parent compound was fixed to a value of 100 -in this fit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +in this fit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ in this fit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ in this fit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ in this fit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,30 +62,23 @@ in this fit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Results of fitting the SFO model to Datasets A to F of FOCUS (2006)</h1> @@ -155,57 +94,67 @@ the initial concentration of the parent compound was fixed to a value of 100 in this fit.</p> </div> - <pre class="usage"><span class='va'>FOCUS_2006_SFO_ref_A_to_F</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">FOCUS_2006_SFO_ref_A_to_F</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> +<dd><p>a factor giving the name of the software package</p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>M0</code></dt> +<dd><p>The fitted initial concentration of the parent compound</p></dd> - <p>A data frame containing the following variables.</p><dl> - <dt><code>package</code></dt><dd><p>a factor giving the name of the software package</p></dd> - <dt><code>M0</code></dt><dd><p>The fitted initial concentration of the parent compound</p></dd> - <dt><code>k</code></dt><dd><p>The fitted first-order degradation rate constant</p></dd> - <dt><code>DT50</code></dt><dd><p>The resulting half-life of the parent compound</p></dd> - <dt><code>DT90</code></dt><dd><p>The resulting DT90 of the parent compound</p></dd> - <dt><code>dataset</code></dt><dd><p>The FOCUS dataset that was used</p></dd> - -</dl> + <dt><code>k</code></dt> +<dd><p>The fitted first-order degradation rate constant</p></dd> + + <dt><code>DT50</code></dt> +<dd><p>The resulting half-life of the parent compound</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>DT90</code></dt> +<dd><p>The resulting DT90 of the parent compound</p></dd> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and + <dt><code>dataset</code></dt> +<dd><p>The FOCUS dataset that was used</p></dd> + + +</dl></div> + <div id="source"> + <h2>Source</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/utils/data.html'>data</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_SFO_ref_A_to_F</span><span class='op'>)</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_SFO_ref_A_to_F</span><span class="op">)</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/FOCUS_2006_datasets.html b/docs/reference/FOCUS_2006_datasets.html index 7a39dcd0..a1004d39 100644 --- a/docs/reference/FOCUS_2006_datasets.html +++ b/docs/reference/FOCUS_2006_datasets.html @@ -1,67 +1,12 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Datasets A to F from the FOCUS Kinetics report from 2006 — FOCUS_2006_datasets • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - 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- - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -72,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,30 +58,23 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Datasets A to F from the FOCUS Kinetics report from 2006</h1> @@ -147,68 +86,73 @@ <p>Data taken from FOCUS (2006), p. 258.</p> </div> - <pre class="usage"><span class='va'>FOCUS_2006_A</span> - <span class='va'>FOCUS_2006_B</span> - <span class='va'>FOCUS_2006_C</span> - <span class='va'>FOCUS_2006_D</span> - <span class='va'>FOCUS_2006_E</span> - <span class='va'>FOCUS_2006_F</span></pre> - + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">FOCUS_2006_A</span> + <span class="va">FOCUS_2006_B</span> + <span class="va">FOCUS_2006_C</span> + <span class="va">FOCUS_2006_D</span> + <span class="va">FOCUS_2006_E</span> + <span class="va">FOCUS_2006_F</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <div id="format"> + <h2>Format</h2> + <p>6 datasets with observations on the following variables.</p><dl><dt><code>name</code></dt> +<dd><p>a factor containing the name of the observed variable</p></dd> - <p>6 datasets with observations on the following variables.</p><dl> - <dt><code>name</code></dt><dd><p>a factor containing the name of the observed variable</p></dd> - <dt><code>time</code></dt><dd><p>a numeric vector containing time points</p></dd> - <dt><code>value</code></dt><dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> - -</dl> + <dt><code>time</code></dt> +<dd><p>a numeric vector containing time points</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>value</code></dt> +<dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and + +</dl></div> + <div id="source"> + <h2>Source</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>FOCUS_2006_C</span> -</div><div class='output co'>#> name time value -#> 1 parent 0 85.1 -#> 2 parent 1 57.9 -#> 3 parent 3 29.9 -#> 4 parent 7 14.6 -#> 5 parent 14 9.7 -#> 6 parent 28 6.6 -#> 7 parent 63 4.0 -#> 8 parent 91 3.9 -#> 9 parent 119 0.6</div></pre> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">FOCUS_2006_C</span></span> +<span class="r-out co"><span class="r-pr">#></span> name time value</span> +<span class="r-out co"><span class="r-pr">#></span> 1 parent 0 85.1</span> +<span class="r-out co"><span class="r-pr">#></span> 2 parent 1 57.9</span> +<span class="r-out co"><span class="r-pr">#></span> 3 parent 3 29.9</span> +<span class="r-out co"><span class="r-pr">#></span> 4 parent 7 14.6</span> +<span class="r-out co"><span class="r-pr">#></span> 5 parent 14 9.7</span> +<span class="r-out co"><span class="r-pr">#></span> 6 parent 28 6.6</span> +<span class="r-out co"><span class="r-pr">#></span> 7 parent 63 4.0</span> +<span class="r-out co"><span class="r-pr">#></span> 8 parent 91 3.9</span> +<span class="r-out co"><span class="r-pr">#></span> 9 parent 119 0.6</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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- +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ a decreasing rate constant." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ a decreasing rate constant." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ a decreasing rate constant." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ a decreasing rate constant." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>First-Order Multi-Compartment kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>FOMC.solution.Rd</code></div> </div> @@ -149,98 +88,94 @@ a decreasing rate constant." /> a decreasing rate constant.</p> </div> - <pre class="usage"><span class='fu'>FOMC.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>alpha</span>, <span class='va'>beta</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>Shape parameter determined by coefficient of variation of rate -constant values.</p></td> - </tr> - <tr> - <th>beta</th> - <td><p>Location parameter.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">alpha</span>, <span class="va">beta</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>alpha</dt> +<dd><p>Shape parameter determined by coefficient of variation of rate +constant values.</p></dd> +<dt>beta</dt> +<dd><p>Location parameter.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>The form given here differs slightly from the original reference by Gustafson and Holden (1990). The parameter <code>beta</code> corresponds to 1/beta in the original equation.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - + </div> + <div id="note"> + <h2>Note</h2> <p>The solution of the FOMC kinetic model reduces to the -<code><a href='SFO.solution.html'>SFO.solution</a></code> for large values of <code>alpha</code> and +<code><a href="SFO.solution.html">SFO.solution</a></code> for large values of <code>alpha</code> and <code>beta</code> with \(k = \frac{\beta}{\alpha}\).</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> -<p>FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> +<p>FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> <p>Gustafson DI and Holden LR (1990) Nonlinear pesticide dissipation in soil: A new model based on spatial variability. <em>Environmental Science and Technology</em> <b>24</b>, 1032-1038</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>FOMC.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>10</span>, <span class='fl'>2</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='FOMC.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">10</span>, <span class="fl">2</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="FOMC.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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<ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ between them." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ between them." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Hockey-Stick kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>HS.solution.Rd</code></div> </div> @@ -149,90 +88,82 @@ between them." /> between them.</p> </div> - <pre class="usage"><span class='fu'>HS.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>tb</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>k1</th> - <td><p>First kinetic constant.</p></td> - </tr> - <tr> - <th>k2</th> - <td><p>Second kinetic constant.</p></td> - </tr> - <tr> - <th>tb</th> - <td><p>Break point. Before this time, exponential decline according to -<code>k1</code> is calculated, after this time, exponential decline proceeds -according to <code>k2</code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">HS.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">tb</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>k1</dt> +<dd><p>First kinetic constant.</p></dd> +<dt>k2</dt> +<dd><p>Second kinetic constant.</p></dd> +<dt>tb</dt> +<dd><p>Break point. Before this time, exponential decline according to +<code>k1</code> is calculated, after this time, exponential decline proceeds +according to <code>k2</code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>HS.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>2</span>, <span class='fl'>0.3</span>, <span class='fl'>0.5</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim<span class='op'>=</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>,<span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='HS.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">HS.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">2</span>, <span class="fl">0.3</span>, <span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim<span class="op">=</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="HS.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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+<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ a concentration dependent rate constant." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ a concentration dependent rate constant." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ a concentration dependent rate constant." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ a concentration dependent rate constant." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Indeterminate order rate equation kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>IORE.solution.Rd</code></div> </div> @@ -149,100 +88,97 @@ a concentration dependent rate constant." /> a concentration dependent rate constant.</p> </div> - <pre class="usage"><span class='fu'>IORE.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k__iore</span>, <span class='va'>N</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>k__iore</th> - <td><p>Rate constant. Note that this depends on the concentration -units used.</p></td> - </tr> - <tr> - <th>N</th> - <td><p>Exponent describing the nonlinearity of the rate equation</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">IORE.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k__iore</span>, <span class="va">N</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>k__iore</dt> +<dd><p>Rate constant. Note that this depends on the concentration +units used.</p></dd> +<dt>N</dt> +<dd><p>Exponent describing the nonlinearity of the rate equation</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - + </div> + <div id="note"> + <h2>Note</h2> <p>The solution of the IORE kinetic model reduces to the -<code><a href='SFO.solution.html'>SFO.solution</a></code> if N = 1. The parameters of the IORE model can +<code><a href="SFO.solution.html">SFO.solution</a></code> if N = 1. The parameters of the IORE model can be transformed to equivalent parameters of the FOMC mode - see the NAFTA guidance for details.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>NAFTA Technical Working Group on Pesticides (not dated) Guidance for Evaluating and Calculating Degradation Kinetics in Environmental Media</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>IORE.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.2</span>, <span class='fl'>1.3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='IORE.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='co'># \dontrun{</span> - <span class='va'>fit.fomc</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>fit.iore</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"IORE"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>fit.iore.deS</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"IORE"</span>, <span class='va'>FOCUS_2006_C</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - - <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span><span class='va'>fit.fomc</span><span class='op'>$</span><span class='va'>par</span>, <span class='va'>fit.iore</span><span class='op'>$</span><span class='va'>par</span>, <span class='va'>fit.iore.deS</span><span class='op'>$</span><span class='va'>par</span>, - row.names <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"model par"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>4</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> fit.fomc.par fit.iore.par fit.iore.deS.par -#> model par 1 85.87489063 85.874890 85.874890 -#> model par 2 0.05192238 -4.826631 -4.826631 -#> model par 3 0.65096665 1.949403 1.949403 -#> model par 4 1.85744396 1.857444 1.857444</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/cbind.html'>rbind</a></span><span class='op'>(</span>fomc <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.fomc</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span>, iore <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.iore</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span>, - iore.deS <span class='op'>=</span> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.iore</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> DT50 DT90 DT50back -#> fomc 1.785233 15.1479 4.559973 -#> iore 1.785233 15.1479 4.559973 -#> iore.deS 1.785233 15.1479 4.559973</div><div class='input'> <span class='co'># }</span> - -</div></pre> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">IORE.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.2</span>, <span class="fl">1.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="IORE.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit.fomc</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">fit.iore</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">fit.iore.deS</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore.deS</span><span class="op">$</span><span class="va">par</span>, </span> +<span class="r-in"> row.names <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"model par"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> fit.fomc.par fit.iore.par fit.iore.deS.par</span> +<span class="r-out co"><span class="r-pr">#></span> model par 1 85.87489063 85.874890 85.874890</span> +<span class="r-out co"><span class="r-pr">#></span> model par 2 0.05192238 -4.826631 -4.826631</span> +<span class="r-out co"><span class="r-pr">#></span> model par 3 0.65096665 1.949403 1.949403</span> +<span class="r-out co"><span class="r-pr">#></span> model par 4 1.85744396 1.857444 1.857444</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span>fomc <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>, iore <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>, </span> +<span class="r-in"> iore.deS <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> +<span class="r-out co"><span class="r-pr">#></span> fomc 1.785233 15.1479 4.559973</span> +<span class="r-out co"><span class="r-pr">#></span> iore 1.785233 15.1479 4.559973</span> +<span class="r-out co"><span class="r-pr">#></span> iore.deS 1.785233 15.1479 4.559973</span> +<span class="r-in"> <span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/NAFTA_SOP_2015-1.png b/docs/reference/NAFTA_SOP_2015-1.png Binary files differindex 4f0d7833..5d2d434b 100644 --- a/docs/reference/NAFTA_SOP_2015-1.png +++ b/docs/reference/NAFTA_SOP_2015-1.png diff --git a/docs/reference/NAFTA_SOP_2015.html 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data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,30 +58,23 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Example datasets from the NAFTA SOP published 2015</h1> @@ -147,97 +86,107 @@ <p>Data taken from US EPA (2015), p. 19 and 23.</p> </div> - <pre class="usage"><span class='va'>NAFTA_SOP_Appendix_B</span> - <span class='va'>NAFTA_SOP_Appendix_D</span></pre> - + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">NAFTA_SOP_Appendix_B</span> + <span class="va">NAFTA_SOP_Appendix_D</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <div id="format"> + <h2>Format</h2> + <p>2 datasets with observations on the following variables.</p><dl><dt><code>name</code></dt> +<dd><p>a factor containing the name of the observed variable</p></dd> - <p>2 datasets with observations on the following variables.</p><dl> - <dt><code>name</code></dt><dd><p>a factor containing the name of the observed variable</p></dd> - <dt><code>time</code></dt><dd><p>a numeric vector containing time points</p></dd> - <dt><code>value</code></dt><dd><p>a numeric vector containing concentrations</p></dd> - -</dl> + <dt><code>time</code></dt> +<dd><p>a numeric vector containing time points</p></dd> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>value</code></dt> +<dd><p>a numeric vector containing concentrations</p></dd> + +</dl></div> + <div id="source"> + <h2>Source</h2> <p>NAFTA (2011) Guidance for evaluating and calculating degradation kinetics in environmental media. NAFTA Technical Working Group on Pesticides - <a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> + <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> accessed 2019-02-22</p> <p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-life Values and Characterizing Pesticide Degradation - <a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> <span class='va'>nafta_evaluation</span> <span class='op'><-</span> <span class='fu'><a href='nafta.html'>nafta</a></span><span class='op'>(</span><span class='va'>NAFTA_SOP_Appendix_D</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#> <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#> <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#> <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>nafta_evaluation</span><span class='op'>)</span> -</div><div class='output co'>#> Sums of squares: -#> SFO IORE DFOP -#> 1378.6832 615.7730 517.8836 -#> -#> Critical sum of squares for checking the SFO model: -#> [1] 717.4598 -#> -#> Parameters: -#> $SFO -#> Estimate Pr(>t) Lower Upper -#> parent_0 83.7558 1.80e-14 77.18268 90.3288 -#> k_parent 0.0017 7.43e-05 0.00112 0.0026 -#> sigma 8.7518 1.22e-05 5.64278 11.8608 -#> -#> $IORE -#> Estimate Pr(>t) Lower Upper -#> parent_0 9.69e+01 NA 8.88e+01 1.05e+02 -#> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09 -#> N_parent 6.68e+00 NA 4.19e+00 9.17e+00 -#> sigma 5.85e+00 NA 3.76e+00 7.94e+00 -#> -#> $DFOP -#> Estimate Pr(>t) Lower Upper -#> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02 -#> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02 -#> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03 -#> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01 -#> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00 -#> -#> -#> DTx values: -#> DT50 DT90 DT50_rep -#> SFO 407 1350 407 -#> IORE 541 5190000 1560000 -#> DFOP 429 2380 841 -#> -#> Representative half-life: -#> [1] 841.41</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>nafta_evaluation</span><span class='op'>)</span> -</div><div class='img'><img src='NAFTA_SOP_2015-1.png' alt='' width='700' height='433' /></div></pre> + <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"> <span class="va">nafta_evaluation</span> <span class="op"><-</span> <span class="fu"><a href="nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Appendix_D</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> +<span class="r-msg co"><span class="r-pr">#></span> The representative half-life of the IORE model is longer than the one corresponding</span> +<span class="r-msg co"><span class="r-pr">#></span> to the terminal degradation rate found with the DFOP model.</span> +<span class="r-msg co"><span class="r-pr">#></span> The representative half-life obtained from the DFOP model may be used</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> +<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> +<span class="r-out co"><span class="r-pr">#></span> 1378.6832 615.7730 517.8836 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 717.4598</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 83.7558 1.80e-14 77.18268 90.3288</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0017 7.43e-05 0.00112 0.0026</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 8.7518 1.22e-05 5.64278 11.8608</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $IORE</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 9.69e+01 NA 8.88e+01 1.05e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09</span> +<span class="r-out co"><span class="r-pr">#></span> N_parent 6.68e+00 NA 4.19e+00 9.17e+00</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.85e+00 NA 3.76e+00 7.94e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03</span> +<span class="r-out co"><span class="r-pr">#></span> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 407 1350 407</span> +<span class="r-out co"><span class="r-pr">#></span> IORE 541 5190000 1560000</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 429 2380 841</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 841.41</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span> +<span class="r-plt img"><img src="NAFTA_SOP_2015-1.png" alt="" width="700" height="433"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - 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-</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Example datasets from Attachment 1 to the NAFTA SOP published 2015</h1> @@ -147,91 +86,96 @@ <p>Data taken from from Attachment 1 of the SOP.</p> </div> - <pre class="usage"><span class='va'>NAFTA_SOP_Attachment</span></pre> - - - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">NAFTA_SOP_Attachment</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> <p>A list (NAFTA_SOP_Attachment) containing 16 datasets suitable - for the evaluation with <code><a href='nafta.html'>nafta</a></code></p> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> - + for the evaluation with <code><a href="nafta.html">nafta</a></code></p> + </div> + <div id="source"> + <h2>Source</h2> <p>NAFTA (2011) Guidance for evaluating and calculating degradation kinetics in environmental media. NAFTA Technical Working Group on Pesticides - <a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> + <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> accessed 2019-02-22</p> <p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-life Values and Characterizing Pesticide Degradation - <a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> <span class='va'>nafta_att_p5a</span> <span class='op'><-</span> <span class='fu'><a href='nafta.html'>nafta</a></span><span class='op'>(</span><span class='va'>NAFTA_SOP_Attachment</span><span class='op'>[[</span><span class='st'>"p5a"</span><span class='op'>]</span><span class='op'>]</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#> <span class='message'>The half-life obtained from the IORE model may be used</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>nafta_att_p5a</span><span class='op'>)</span> -</div><div class='output co'>#> Sums of squares: -#> SFO IORE DFOP -#> 465.21753 56.27506 32.06401 -#> -#> Critical sum of squares for checking the SFO model: -#> [1] 64.4304 -#> -#> Parameters: -#> $SFO -#> Estimate Pr(>t) Lower Upper -#> parent_0 95.8401 4.67e-21 92.245 99.4357 -#> k_parent 0.0102 3.92e-12 0.009 0.0117 -#> sigma 4.8230 3.81e-06 3.214 6.4318 -#> -#> $IORE -#> Estimate Pr(>t) Lower Upper -#> parent_0 1.01e+02 NA 9.91e+01 1.02e+02 -#> k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05 -#> N_parent 2.57e+00 NA 2.25e+00 2.89e+00 -#> sigma 1.68e+00 NA 1.12e+00 2.24e+00 -#> -#> $DFOP -#> Estimate Pr(>t) Lower Upper -#> parent_0 9.99e+01 1.41e-26 98.8116 101.0810 -#> k1 2.67e-02 5.05e-06 0.0243 0.0295 -#> k2 2.26e-12 5.00e-01 0.0000 Inf -#> g 6.47e-01 3.67e-06 0.6248 0.6677 -#> sigma 1.27e+00 8.91e-06 0.8395 1.6929 -#> -#> -#> DTx values: -#> DT50 DT90 DT50_rep -#> SFO 67.7 2.25e+02 6.77e+01 -#> IORE 58.2 1.07e+03 3.22e+02 -#> DFOP 55.5 5.59e+11 3.07e+11 -#> -#> Representative half-life: -#> [1] 321.51</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>nafta_att_p5a</span><span class='op'>)</span> -</div><div class='img'><img src='NAFTA_SOP_Attachment-1.png' alt='' width='700' height='433' /></div></pre> + <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"> <span class="va">nafta_att_p5a</span> <span class="op"><-</span> <span class="fu"><a href="nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5a"</span><span class="op">]</span><span class="op">]</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> +<span class="r-msg co"><span class="r-pr">#></span> The half-life obtained from the IORE model may be used</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_att_p5a</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> +<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> +<span class="r-out co"><span class="r-pr">#></span> 465.21753 56.27506 32.06401 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 64.4304</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 95.8401 4.67e-21 92.245 99.4357</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0102 3.92e-12 0.009 0.0117</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 4.8230 3.81e-06 3.214 6.4318</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $IORE</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.01e+02 NA 9.91e+01 1.02e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05</span> +<span class="r-out co"><span class="r-pr">#></span> N_parent 2.57e+00 NA 2.25e+00 2.89e+00</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.68e+00 NA 1.12e+00 2.24e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 9.99e+01 1.41e-26 98.8116 101.0810</span> +<span class="r-out co"><span class="r-pr">#></span> k1 2.67e-02 5.05e-06 0.0243 0.0295</span> +<span class="r-out co"><span class="r-pr">#></span> k2 2.26e-12 5.00e-01 0.0000 Inf</span> +<span class="r-out co"><span class="r-pr">#></span> g 6.47e-01 3.67e-06 0.6248 0.6677</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.27e+00 8.91e-06 0.8395 1.6929</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 67.7 2.25e+02 6.77e+01</span> +<span class="r-out co"><span class="r-pr">#></span> IORE 58.2 1.07e+03 3.22e+02</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 55.5 5.59e+11 3.07e+11</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 321.51</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_att_p5a</span><span class="op">)</span></span> +<span class="r-plt img"><img src="NAFTA_SOP_Attachment-1.png" alt="" width="700" height="433"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - 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class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Single First-Order kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>SFO.solution.Rd</code></div> </div> @@ -147,80 +86,76 @@ <p>Function describing exponential decline from a defined starting value.</p> </div> - <pre class="usage"><span class='fu'>SFO.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>k</th> - <td><p>Kinetic rate constant.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">SFO.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>k</dt> +<dd><p>Kinetic rate constant.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>SFO.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span><span class='op'>)</span> -</div><div class='img'><img src='SFO.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFO.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span> +<span class="r-plt img"><img src="SFO.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + 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href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Single First-Order Reversible Binding kinetics — SFORB.solution"><meta property="og:description" content="Function describing the solution of the differential equations describing the kinetic model with first-order terms for a two-way transfer from a free to a bound fraction, and a first-order degradation term for the free fraction. The initial condition is a defined amount in the free fraction -and no substance in the bound fraction." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +and no substance in the bound fraction."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ and no substance in the bound fraction." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ and no substance in the bound fraction." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ and no substance in the bound fraction." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,34 +62,27 @@ and no substance in the bound fraction." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Single First-Order Reversible Binding kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>SFORB.solution.Rd</code></div> </div> @@ -155,90 +94,82 @@ fraction. The initial condition is a defined amount in the free fraction and no substance in the bound fraction.</p> </div> - <pre class="usage"><span class='fu'>SFORB.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>k_12</span>, <span class='va'>k_21</span>, <span class='va'>k_1output</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>k_12</th> - <td><p>Kinetic constant describing transfer from free to bound.</p></td> - </tr> - <tr> - <th>k_21</th> - <td><p>Kinetic constant describing transfer from bound to free.</p></td> - </tr> - <tr> - <th>k_1output</th> - <td><p>Kinetic constant describing degradation of the free -fraction.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k_12</span>, <span class="va">k_21</span>, <span class="va">k_1output</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>k_12</dt> +<dd><p>Kinetic constant describing transfer from free to bound.</p></dd> +<dt>k_21</dt> +<dd><p>Kinetic constant describing transfer from bound to free.</p></dd> +<dt>k_1output</dt> +<dd><p>Kinetic constant describing degradation of the free +fraction.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable, which is the sum of free and bound fractions at time <code>t</code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='logistic.solution.html'>logistic.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>SFORB.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.5</span>, <span class='fl'>2</span>, <span class='fl'>3</span><span class='op'>)</span>, <span class='fl'>0</span>, <span class='fl'>2</span><span class='op'>)</span> -</div><div class='img'><img src='SFORB.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.5</span>, <span class="fl">2</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span> +<span class="r-plt img"><img src="SFORB.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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The variance of the error -may depend on the predicted value and is specified as a standard deviation." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +may depend on the predicted value and is specified as a standard deviation."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ may depend on the predicted value and is specified as a standard deviation." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ may depend on the predicted value and is specified as a standard deviation." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ may depend on the predicted value and is specified as a standard deviation." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,181 +60,163 @@ may depend on the predicted value and is specified as a standard deviation." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Add normally distributed errors to simulated kinetic degradation data</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/add_err.R'><code>R/add_err.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/add_err.R" class="external-link"><code>R/add_err.R</code></a></small> <div class="hidden name"><code>add_err.Rd</code></div> </div> <div class="ref-description"> <p>Normally distributed errors are added to data predicted for a specific -degradation model using <code><a href='mkinpredict.html'>mkinpredict</a></code>. The variance of the error +degradation model using <code><a href="mkinpredict.html">mkinpredict</a></code>. The variance of the error may depend on the predicted value and is specified as a standard deviation.</p> </div> - <pre class="usage"><span class='fu'>add_err</span><span class='op'>(</span> - <span class='va'>prediction</span>, - <span class='va'>sdfunc</span>, - secondary <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span>, - n <span class='op'>=</span> <span class='fl'>10</span>, - LOD <span class='op'>=</span> <span class='fl'>0.1</span>, - reps <span class='op'>=</span> <span class='fl'>2</span>, - digits <span class='op'>=</span> <span class='fl'>1</span>, - seed <span class='op'>=</span> <span class='cn'>NA</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">add_err</span><span class="op">(</span> + <span class="va">prediction</span>, + <span class="va">sdfunc</span>, + secondary <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>, + n <span class="op">=</span> <span class="fl">10</span>, + LOD <span class="op">=</span> <span class="fl">0.1</span>, + reps <span class="op">=</span> <span class="fl">2</span>, + digits <span class="op">=</span> <span class="fl">1</span>, + seed <span class="op">=</span> <span class="cn">NA</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>prediction</th> - <td><p>A prediction from a kinetic model as produced by -<code><a href='mkinpredict.html'>mkinpredict</a></code>.</p></td> - </tr> - <tr> - <th>sdfunc</th> - <td><p>A function taking the predicted value as its only argument and + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>prediction</dt> +<dd><p>A prediction from a kinetic model as produced by +<code><a href="mkinpredict.html">mkinpredict</a></code>.</p></dd> +<dt>sdfunc</dt> +<dd><p>A function taking the predicted value as its only argument and returning a standard deviation that should be used for generating the -random error terms for this value.</p></td> - </tr> - <tr> - <th>secondary</th> - <td><p>The names of state variables that should have an initial -value of zero</p></td> - </tr> - <tr> - <th>n</th> - <td><p>The number of datasets to be generated.</p></td> - </tr> - <tr> - <th>LOD</th> - <td><p>The limit of detection (LOD). Values that are below the LOD after -adding the random error will be set to NA.</p></td> - </tr> - <tr> - <th>reps</th> - <td><p>The number of replicates to be generated within the datasets.</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>The number of digits to which the values will be rounded.</p></td> - </tr> - <tr> - <th>seed</th> - <td><p>The seed used for the generation of random numbers. If NA, the -seed is not set.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>A list of datasets compatible with <code><a href='mmkin.html'>mmkin</a></code>, i.e. the -components of the list are datasets compatible with <code><a href='mkinfit.html'>mkinfit</a></code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - +random error terms for this value.</p></dd> +<dt>secondary</dt> +<dd><p>The names of state variables that should have an initial +value of zero</p></dd> +<dt>n</dt> +<dd><p>The number of datasets to be generated.</p></dd> +<dt>LOD</dt> +<dd><p>The limit of detection (LOD). Values that are below the LOD after +adding the random error will be set to NA.</p></dd> +<dt>reps</dt> +<dd><p>The number of replicates to be generated within the datasets.</p></dd> +<dt>digits</dt> +<dd><p>The number of digits to which the values will be rounded.</p></dd> +<dt>seed</dt> +<dd><p>The seed used for the generation of random numbers. If NA, the +seed is not set.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>A list of datasets compatible with <code><a href="mmkin.html">mmkin</a></code>, i.e. the +components of the list are datasets compatible with <code><a href="mkinfit.html">mkinfit</a></code>.</p> + </div> + <div id="references"> + <h2>References</h2> <p>Ranke J and Lehmann R (2015) To t-test or not to t-test, that is the question. XV Symposium on Pesticide Chemistry 2-4 September 2015, Piacenza, Italy https://jrwb.de/posters/piacenza_2015.pdf</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># The kinetic model</span> -<span class='va'>m_SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='co'># Generate a prediction for a specific set of parameters</span> -<span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> - -<span class='co'># This is the prediction used for the "Type 2 datasets" on the Piacenza poster</span> -<span class='co'># from 2015</span> -<span class='va'>d_SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_SFO_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.1</span>, f_parent_to_M1 <span class='op'>=</span> <span class='fl'>0.5</span>, - k_M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>2</span><span class='op'>)</span><span class='op'>/</span><span class='fl'>1000</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, M1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - -<span class='co'># Add an error term with a constant (independent of the value) standard deviation</span> -<span class='co'># of 10, and generate three datasets</span> -<span class='va'>d_SFO_SFO_err</span> <span class='op'><-</span> <span class='fu'>add_err</span><span class='op'>(</span><span class='va'>d_SFO_SFO</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fl'>10</span>, n <span class='op'>=</span> <span class='fl'>3</span>, seed <span class='op'>=</span> <span class='fl'>123456789</span> <span class='op'>)</span> - -<span class='co'># Name the datasets for nicer plotting</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>d_SFO_SFO_err</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"Dataset"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>)</span> - -<span class='co'># Name the model in the list of models (with only one member in this case) for</span> -<span class='co'># nicer plotting later on. Be quiet and use only one core not to offend CRAN</span> -<span class='co'># checks</span> -<span class='co'># \dontrun{</span> -<span class='va'>f_SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"SFO-SFO"</span> <span class='op'>=</span> <span class='va'>m_SFO_SFO</span><span class='op'>)</span>, - <span class='va'>d_SFO_SFO_err</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_SFO_SFO</span><span class='op'>)</span> -</div><div class='img'><img src='add_err-1.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># We would like to inspect the fit for dataset 3 more closely</span> -<span class='co'># Using double brackets makes the returned object an mkinfit object</span> -<span class='co'># instead of a list of mkinfit objects, so plot.mkinfit is used</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_SFO_SFO</span><span class='op'>[[</span><span class='fl'>3</span><span class='op'>]</span><span class='op'>]</span>, show_residuals <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='add_err-2.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># If we use single brackets, we should give two indices (model and dataset),</span> -<span class='co'># and plot.mmkin is used</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_SFO_SFO</span><span class='op'>[</span><span class='fl'>1</span>, <span class='fl'>3</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='add_err-3.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># The kinetic model</span></span> +<span class="r-in"><span class="va">m_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Generate a prediction for a specific set of parameters</span></span> +<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># This is the prediction used for the "Type 2 datasets" on the Piacenza poster</span></span> +<span class="r-in"><span class="co"># from 2015</span></span> +<span class="r-in"><span class="va">d_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.1</span>, f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>,</span> +<span class="r-in"> k_M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">1000</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Add an error term with a constant (independent of the value) standard deviation</span></span> +<span class="r-in"><span class="co"># of 10, and generate three datasets</span></span> +<span class="r-in"><span class="va">d_SFO_SFO_err</span> <span class="op"><-</span> <span class="fu">add_err</span><span class="op">(</span><span class="va">d_SFO_SFO</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fl">10</span>, n <span class="op">=</span> <span class="fl">3</span>, seed <span class="op">=</span> <span class="fl">123456789</span> <span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Name the datasets for nicer plotting</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">d_SFO_SFO_err</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Name the model in the list of models (with only one member in this case) for</span></span> +<span class="r-in"><span class="co"># nicer plotting later on. Be quiet and use only one core not to offend CRAN</span></span> +<span class="r-in"><span class="co"># checks</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">f_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">m_SFO_SFO</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">d_SFO_SFO_err</span>, cores <span class="op">=</span> <span class="fl">1</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">)</span></span> +<span class="r-plt img"><img src="add_err-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># We would like to inspect the fit for dataset 3 more closely</span></span> +<span class="r-in"><span class="co"># Using double brackets makes the returned object an mkinfit object</span></span> +<span class="r-in"><span class="co"># instead of a list of mkinfit objects, so plot.mkinfit is used</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">[[</span><span class="fl">3</span><span class="op">]</span><span class="op">]</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="add_err-2.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># If we use single brackets, we should give two indices (model and dataset),</span></span> +<span class="r-in"><span class="co"># and plot.mmkin is used</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">[</span><span class="fl">1</span>, <span class="fl">3</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="add_err-3.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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<li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ by Burnham and Anderson (2004)." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ by Burnham and Anderson (2004)." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,34 +60,27 @@ by Burnham and Anderson (2004)." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Calculate Akaike weights for model averaging</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/aw.R'><code>R/aw.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/aw.R" class="external-link"><code>R/aw.R</code></a></small> <div class="hidden name"><code>aw.Rd</code></div> </div> @@ -151,76 +90,76 @@ expected Kullback-Leibler information as specified by Burnham and Anderson (2004).</p> </div> - <pre class="usage"><span class='fu'>aw</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> -<span class='co'># S3 method for mkinfit</span> -<span class='fu'>aw</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> +<span class="co"># S3 method for mkinfit</span> +<span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> -<span class='co'># S3 method for mmkin</span> -<span class='fu'>aw</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> +<span class="co"># S3 method for mmkin</span> +<span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An <a href='mmkin.html'>mmkin</a> column object, containing two or more -<a href='mkinfit.html'>mkinfit</a> models that have been fitted to the same data, + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <a href="mmkin.html">mmkin</a> column object, containing two or more +<a href="mkinfit.html">mkinfit</a> models that have been fitted to the same data, or an mkinfit object. In the latter case, further mkinfit objects fitted to the same data should be specified -as dots arguments.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used in the method for <a href='mmkin.html'>mmkin</a> column objects, -further <a href='mkinfit.html'>mkinfit</a> objects in the method for mkinfit objects.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - +as dots arguments.</p></dd> +<dt>...</dt> +<dd><p>Not used in the method for <a href="mmkin.html">mmkin</a> column objects, +further <a href="mkinfit.html">mkinfit</a> objects in the method for mkinfit objects.</p></dd> +</dl></div> + <div id="references"> + <h2>References</h2> <p>Burnham KP and Anderson DR (2004) Multimodel Inference: Understanding AIC and BIC in Model Selection. <em>Sociological Methods & Research</em> <strong>33</strong>(2) 261-304</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> -<span class='va'>f_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>f_dfop</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>aw_sfo_dfop</span> <span class='op'><-</span> <span class='fu'>aw</span><span class='op'>(</span><span class='va'>f_sfo</span>, <span class='va'>f_dfop</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='va'>aw_sfo_dfop</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 1</div><div class='input'><span class='va'>aw_sfo_dfop</span> <span class='co'># SFO gets more weight as it has less parameters and a similar fit</span> -</div><div class='output co'>#> [1] 0.5970258 0.4029742</div><div class='input'><span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"FOCUS D"</span> <span class='op'>=</span> <span class='va'>FOCUS_2006_D</span><span class='op'>)</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'>aw</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.4808722 0.1945539 0.3245740</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='fu'>aw</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 1</div><div class='input'><span class='fu'>aw</span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.5970258 0.4029742</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">f_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_dfop</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">aw_sfo_dfop</span> <span class="op"><-</span> <span class="fu">aw</span><span class="op">(</span><span class="va">f_sfo</span>, <span class="va">f_dfop</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="va">aw_sfo_dfop</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> +<span class="r-in"><span class="va">aw_sfo_dfop</span> <span class="co"># SFO gets more weight as it has less parameters and a similar fit</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.5970258 0.4029742</span> +<span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS D"</span> <span class="op">=</span> <span class="va">FOCUS_2006_D</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.4808722 0.1945539 0.3245740</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> +<span class="r-in"><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.5970258 0.4029742</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a 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The alternative method 'profile' is based on the profile likelihood for each parameter. The 'profile' method uses two nested optimisations and can take a very long time, even if parallelized by specifying 'cores' on unixoid platforms. The speed of the method could likely be improved by using the -method of Venzon and Moolgavkar (1988)." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +method of Venzon and Moolgavkar (1988)."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -79,13 +24,12 @@ method of Venzon and Moolgavkar (1988)." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -94,8 +38,7 @@ method of Venzon and Moolgavkar (1988)." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -105,6 +48,9 @@ method of Venzon and Moolgavkar (1988)." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -119,34 +65,27 @@ method of Venzon and Moolgavkar (1988)." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Confidence intervals for parameters of mkinfit objects</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/confint.mkinfit.R'><code>R/confint.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/confint.mkinfit.R" class="external-link"><code>R/confint.mkinfit.R</code></a></small> <div class="hidden name"><code>confint.mkinfit.Rd</code></div> </div> @@ -161,279 +100,276 @@ platforms. The speed of the method could likely be improved by using the method of Venzon and Moolgavkar (1988).</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span> - <span class='va'>object</span>, - <span class='va'>parm</span>, - level <span class='op'>=</span> <span class='fl'>0.95</span>, - alpha <span class='op'>=</span> <span class='fl'>1</span> <span class='op'>-</span> <span class='va'>level</span>, - <span class='va'>cutoff</span>, - method <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"quadratic"</span>, <span class='st'>"profile"</span><span class='op'>)</span>, - transformed <span class='op'>=</span> <span class='cn'>TRUE</span>, - backtransform <span class='op'>=</span> <span class='cn'>TRUE</span>, - cores <span class='op'>=</span> <span class='fu'>parallel</span><span class='fu'>::</span><span class='fu'><a href='https://rdrr.io/r/parallel/detectCores.html'>detectCores</a></span><span class='op'>(</span><span class='op'>)</span>, - rel_tol <span class='op'>=</span> <span class='fl'>0.01</span>, - quiet <span class='op'>=</span> <span class='cn'>FALSE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span> + <span class="va">object</span>, + <span class="va">parm</span>, + level <span class="op">=</span> <span class="fl">0.95</span>, + alpha <span class="op">=</span> <span class="fl">1</span> <span class="op">-</span> <span class="va">level</span>, + <span class="va">cutoff</span>, + method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"quadratic"</span>, <span class="st">"profile"</span><span class="op">)</span>, + transformed <span class="op">=</span> <span class="cn">TRUE</span>, + backtransform <span class="op">=</span> <span class="cn">TRUE</span>, + cores <span class="op">=</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span>, + rel_tol <span class="op">=</span> <span class="fl">0.01</span>, + quiet <span class="op">=</span> <span class="cn">FALSE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An <code><a href='mkinfit.html'>mkinfit</a></code> object</p></td> - </tr> - <tr> - <th>parm</th> - <td><p>A vector of names of the parameters which are to be given -confidence intervals. If missing, all parameters are considered.</p></td> - </tr> - <tr> - <th>level</th> - <td><p>The confidence level required</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>The allowed error probability, overrides 'level' if specified.</p></td> - </tr> - <tr> - <th>cutoff</th> - <td><p>Possibility to specify an alternative cutoff for the difference + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <code><a href="mkinfit.html">mkinfit</a></code> object</p></dd> +<dt>parm</dt> +<dd><p>A vector of names of the parameters which are to be given +confidence intervals. If missing, all parameters are considered.</p></dd> +<dt>level</dt> +<dd><p>The confidence level required</p></dd> +<dt>alpha</dt> +<dd><p>The allowed error probability, overrides 'level' if specified.</p></dd> +<dt>cutoff</dt> +<dd><p>Possibility to specify an alternative cutoff for the difference in the log-likelihoods at the confidence boundary. Specifying an explicit -cutoff value overrides arguments 'level' and 'alpha'</p></td> - </tr> - <tr> - <th>method</th> - <td><p>The 'quadratic' method approximates the likelihood function at +cutoff value overrides arguments 'level' and 'alpha'</p></dd> +<dt>method</dt> +<dd><p>The 'quadratic' method approximates the likelihood function at the optimised parameters using the second term of the Taylor expansion, using a second derivative (hessian) contained in the object. The 'profile' method searches the parameter space for the -cutoff of the confidence intervals by means of a likelihood ratio test.</p></td> - </tr> - <tr> - <th>transformed</th> - <td><p>If the quadratic approximation is used, should it be -applied to the likelihood based on the transformed parameters?</p></td> - </tr> - <tr> - <th>backtransform</th> - <td><p>If we approximate the likelihood in terms of the +cutoff of the confidence intervals by means of a likelihood ratio test.</p></dd> +<dt>transformed</dt> +<dd><p>If the quadratic approximation is used, should it be +applied to the likelihood based on the transformed parameters?</p></dd> +<dt>backtransform</dt> +<dd><p>If we approximate the likelihood in terms of the transformed parameters, should we backtransform the parameters with -their confidence intervals?</p></td> - </tr> - <tr> - <th>cores</th> - <td><p>The number of cores to be used for multicore processing. -On Windows machines, cores > 1 is currently not supported.</p></td> - </tr> - <tr> - <th>rel_tol</th> - <td><p>If the method is 'profile', what should be the accuracy +their confidence intervals?</p></dd> +<dt>cores</dt> +<dd><p>The number of cores to be used for multicore processing. +On Windows machines, cores > 1 is currently not supported.</p></dd> +<dt>rel_tol</dt> +<dd><p>If the method is 'profile', what should be the accuracy of the lower and upper bounds, relative to the estimate obtained from -the quadratic method?</p></td> - </tr> - <tr> - <th>quiet</th> - <td><p>Should we suppress the message "Profiling the likelihood"</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +the quadratic method?</p></dd> +<dt>quiet</dt> +<dd><p>Should we suppress the message "Profiling the likelihood"</p></dd> +<dt>...</dt> +<dd><p>Not used</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A matrix with columns giving lower and upper confidence limits for each parameter.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>Bates DM and Watts GW (1988) Nonlinear regression analysis & its applications</p> <p>Pawitan Y (2013) In all likelihood - Statistical modelling and inference using likelihood. Clarendon Press, Oxford.</p> <p>Venzon DJ and Moolgavkar SH (1988) A Method for Computing Profile-Likelihood Based Confidence Intervals, Applied Statistics, 37, 87–94.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span><span class='op'>)</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 71.8242430 93.1600766 -#> k_parent 0.2109541 0.4440528 -#> sigma 1.9778868 7.3681380</div><div class='input'> -<span class='co'># \dontrun{</span> -<span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f</span>, method <span class='op'>=</span> <span class='st'>"profile"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Profiling the likelihood</span></div><div class='output co'>#> 2.5% 97.5% -#> parent_0 73.0641834 92.1392181 -#> k_parent 0.2170293 0.4235348 -#> sigma 3.1307772 8.0628314</div><div class='input'> -<span class='co'># Set the number of cores for the profiling method for further examples</span> -<span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/identical.html'>identical</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/Sys.getenv.html'>Sys.getenv</a></span><span class='op'>(</span><span class='st'>"NOT_CRAN"</span><span class='op'>)</span>, <span class='st'>"true"</span><span class='op'>)</span><span class='op'>)</span> <span class='op'>{</span> - <span class='va'>n_cores</span> <span class='op'><-</span> <span class='fu'>parallel</span><span class='fu'>::</span><span class='fu'><a href='https://rdrr.io/r/parallel/detectCores.html'>detectCores</a></span><span class='op'>(</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>1</span> -<span class='op'>}</span> <span class='kw'>else</span> <span class='op'>{</span> - <span class='va'>n_cores</span> <span class='op'><-</span> <span class='fl'>1</span> -<span class='op'>}</span> -<span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/Sys.getenv.html'>Sys.getenv</a></span><span class='op'>(</span><span class='st'>"TRAVIS"</span><span class='op'>)</span> <span class='op'>!=</span> <span class='st'>""</span><span class='op'>)</span> <span class='va'>n_cores</span> <span class='op'>=</span> <span class='fl'>1</span> -<span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/Sys.info.html'>Sys.info</a></span><span class='op'>(</span><span class='op'>)</span><span class='op'>[</span><span class='st'>"sysname"</span><span class='op'>]</span> <span class='op'>==</span> <span class='st'>"Windows"</span><span class='op'>)</span> <span class='va'>n_cores</span> <span class='op'>=</span> <span class='fl'>1</span> - -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"min"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>SFO_SFO.ff</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>f_d_1</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/system.time.html'>system.time</a></span><span class='op'>(</span><span class='va'>ci_profile</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_1</span>, method <span class='op'>=</span> <span class='st'>"profile"</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> user system elapsed -#> 3.871 0.000 3.871 </div><div class='input'><span class='co'># Using more cores does not save much time here, as parent_0 takes up most of the time</span> -<span class='co'># If we additionally exclude parent_0 (the confidence of which is often of</span> -<span class='co'># minor interest), we get a nice performance improvement if we use at least 4 cores</span> -<span class='fu'><a href='https://rdrr.io/r/base/system.time.html'>system.time</a></span><span class='op'>(</span><span class='va'>ci_profile_no_parent_0</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_1</span>, method <span class='op'>=</span> <span class='st'>"profile"</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"k_parent_sink"</span>, <span class='st'>"k_parent_m1"</span>, <span class='st'>"k_m1_sink"</span>, <span class='st'>"sigma"</span><span class='op'>)</span>, cores <span class='op'>=</span> <span class='va'>n_cores</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Profiling the likelihood</span></div><div class='output co'>#> user system elapsed -#> 1.484 0.116 0.923 </div><div class='input'><span class='va'>ci_profile</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.456003640 1.027703e+02 -#> k_parent_sink 0.040762501 5.549764e-02 -#> k_parent_m1 0.046786482 5.500879e-02 -#> k_m1_sink 0.003892605 6.702778e-03 -#> sigma 2.535612399 3.985263e+00</div><div class='input'><span class='va'>ci_quadratic_transformed</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_1</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span><span class='op'>)</span> -<span class='va'>ci_quadratic_transformed</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.403841640 1.027931e+02 -#> k_parent_sink 0.041033378 5.596269e-02 -#> k_parent_m1 0.046777902 5.511931e-02 -#> k_m1_sink 0.004012217 6.897547e-03 -#> sigma 2.396089689 3.854918e+00</div><div class='input'><span class='va'>ci_quadratic_untransformed</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_1</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span>, transformed <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -<span class='va'>ci_quadratic_untransformed</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.403841645 102.79312449 -#> k_parent_sink 0.040485331 0.05535491 -#> k_parent_m1 0.046611582 0.05494364 -#> k_m1_sink 0.003835483 0.00668582 -#> sigma 2.396089689 3.85491806</div><div class='input'><span class='co'># Against the expectation based on Bates and Watts (1988), the confidence</span> -<span class='co'># intervals based on the internal parameter transformation are less</span> -<span class='co'># congruent with the likelihood based intervals. Note the superiority of the</span> -<span class='co'># interval based on the untransformed fit for k_m1_sink</span> -<span class='va'>rel_diffs_transformed</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>abs</a></span><span class='op'>(</span><span class='op'>(</span><span class='va'>ci_quadratic_transformed</span> <span class='op'>-</span> <span class='va'>ci_profile</span><span class='op'>)</span><span class='op'>/</span><span class='va'>ci_profile</span><span class='op'>)</span> -<span class='va'>rel_diffs_untransformed</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>abs</a></span><span class='op'>(</span><span class='op'>(</span><span class='va'>ci_quadratic_untransformed</span> <span class='op'>-</span> <span class='va'>ci_profile</span><span class='op'>)</span><span class='op'>/</span><span class='va'>ci_profile</span><span class='op'>)</span> -<span class='va'>rel_diffs_transformed</span> <span class='op'><</span> <span class='va'>rel_diffs_untransformed</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 FALSE FALSE -#> k_parent_sink TRUE FALSE -#> k_parent_m1 TRUE FALSE -#> k_m1_sink FALSE FALSE -#> sigma FALSE FALSE</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/Round.html'>signif</a></span><span class='op'>(</span><span class='va'>rel_diffs_transformed</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 0.000541 0.000222 -#> k_parent_sink 0.006650 0.008380 -#> k_parent_m1 0.000183 0.002010 -#> k_m1_sink 0.030700 0.029100 -#> sigma 0.055000 0.032700</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/Round.html'>signif</a></span><span class='op'>(</span><span class='va'>rel_diffs_untransformed</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 0.000541 0.000222 -#> k_parent_sink 0.006800 0.002570 -#> k_parent_m1 0.003740 0.001180 -#> k_m1_sink 0.014700 0.002530 -#> sigma 0.055000 0.032700</div><div class='input'> - -<span class='co'># Investigate a case with formation fractions</span> -<span class='va'>f_d_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.ff</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>ci_profile_ff</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_2</span>, method <span class='op'>=</span> <span class='st'>"profile"</span>, cores <span class='op'>=</span> <span class='va'>n_cores</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Profiling the likelihood</span></div><div class='input'><span class='va'>ci_profile_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.456003640 1.027703e+02 -#> k_parent 0.090911032 1.071578e-01 -#> k_m1 0.003892606 6.702775e-03 -#> f_parent_to_m1 0.471328495 5.611550e-01 -#> sigma 2.535612399 3.985263e+00</div><div class='input'><span class='va'>ci_quadratic_transformed_ff</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_2</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span><span class='op'>)</span> -<span class='va'>ci_quadratic_transformed_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.403833578 102.79311649 -#> k_parent 0.090823771 0.10725430 -#> k_m1 0.004012219 0.00689755 -#> f_parent_to_m1 0.469118824 0.55959615 -#> sigma 2.396089689 3.85491806</div><div class='input'><span class='va'>ci_quadratic_untransformed_ff</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_d_2</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span>, transformed <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -<span class='va'>ci_quadratic_untransformed_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 96.403833583 1.027931e+02 -#> k_parent 0.090491913 1.069035e-01 -#> k_m1 0.003835485 6.685823e-03 -#> f_parent_to_m1 0.469113477 5.598387e-01 -#> sigma 2.396089689 3.854918e+00</div><div class='input'><span class='va'>rel_diffs_transformed_ff</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>abs</a></span><span class='op'>(</span><span class='op'>(</span><span class='va'>ci_quadratic_transformed_ff</span> <span class='op'>-</span> <span class='va'>ci_profile_ff</span><span class='op'>)</span><span class='op'>/</span><span class='va'>ci_profile_ff</span><span class='op'>)</span> -<span class='va'>rel_diffs_untransformed_ff</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>abs</a></span><span class='op'>(</span><span class='op'>(</span><span class='va'>ci_quadratic_untransformed_ff</span> <span class='op'>-</span> <span class='va'>ci_profile_ff</span><span class='op'>)</span><span class='op'>/</span><span class='va'>ci_profile_ff</span><span class='op'>)</span> -<span class='co'># While the confidence interval for the parent rate constant is closer to</span> -<span class='co'># the profile based interval when using the internal parameter</span> -<span class='co'># transformation, the interval for the metabolite rate constant is 'better</span> -<span class='co'># without internal parameter transformation.</span> -<span class='va'>rel_diffs_transformed_ff</span> <span class='op'><</span> <span class='va'>rel_diffs_untransformed_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 FALSE FALSE -#> k_parent TRUE TRUE -#> k_m1 FALSE FALSE -#> f_parent_to_m1 TRUE FALSE -#> sigma TRUE FALSE</div><div class='input'><span class='va'>rel_diffs_transformed_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 0.0005408690 0.0002217233 -#> k_parent 0.0009598532 0.0009001864 -#> k_m1 0.0307283041 0.0290588361 -#> f_parent_to_m1 0.0046881769 0.0027780063 -#> sigma 0.0550252516 0.0327066836</div><div class='input'><span class='va'>rel_diffs_untransformed_ff</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 0.0005408689 0.0002217232 -#> k_parent 0.0046102156 0.0023732281 -#> k_m1 0.0146740690 0.0025291820 -#> f_parent_to_m1 0.0046995211 0.0023457712 -#> sigma 0.0550252516 0.0327066836</div><div class='input'> -<span class='co'># The profiling for the following fit does not finish in a reasonable time,</span> -<span class='co'># therefore we use the quadratic approximation</span> -<span class='va'>m_synth_DFOP_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>DFOP_par_c</span> <span class='op'><-</span> <span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>12</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span> -<span class='va'>f_tc_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_DFOP_par</span>, <span class='va'>DFOP_par_c</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, - error_model_algorithm <span class='op'>=</span> <span class='st'>"direct"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_tc_2</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span><span class='op'>)</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 94.596039609 106.19954892 -#> k_M1 0.037605368 0.04490762 -#> k_M2 0.008568731 0.01087676 -#> f_parent_to_M1 0.021462489 0.62023882 -#> f_parent_to_M2 0.015165617 0.37975348 -#> k1 0.273897348 0.33388101 -#> k2 0.018614554 0.02250378 -#> g 0.671943411 0.73583305 -#> sigma_low 0.251283495 0.83992077 -#> rsd_high 0.040411024 0.07662008</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/stats/confint.html'>confint</a></span><span class='op'>(</span><span class='va'>f_tc_2</span>, <span class='st'>"parent_0"</span>, method <span class='op'>=</span> <span class='st'>"quadratic"</span><span class='op'>)</span> -</div><div class='output co'>#> 2.5% 97.5% -#> parent_0 94.59604 106.1995</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 71.8242430 93.1600766</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.2109541 0.4440528</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.9778868 7.3681380</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f</span>, method <span class="op">=</span> <span class="st">"profile"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 73.0641834 92.1392181</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.2170293 0.4235348</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.1307772 8.0628314</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Set the number of cores for the profiling method for further examples</span></span> +<span class="r-in"><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"NOT_CRAN"</span><span class="op">)</span>, <span class="st">"true"</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="va">n_cores</span> <span class="op"><-</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span> <span class="op">-</span> <span class="fl">1</span></span> +<span class="r-in"><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> +<span class="r-in"> <span class="va">n_cores</span> <span class="op"><-</span> <span class="fl">1</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"TRAVIS"</span><span class="op">)</span> <span class="op">!=</span> <span class="st">""</span><span class="op">)</span> <span class="va">n_cores</span> <span class="op">=</span> <span class="fl">1</span></span> +<span class="r-in"><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="va">n_cores</span> <span class="op">=</span> <span class="fl">1</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"min"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">SFO_SFO.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_d_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">ci_profile</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"profile"</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 3.933 0.000 3.934 </span> +<span class="r-in"><span class="co"># Using more cores does not save much time here, as parent_0 takes up most of the time</span></span> +<span class="r-in"><span class="co"># If we additionally exclude parent_0 (the confidence of which is often of</span></span> +<span class="r-in"><span class="co"># minor interest), we get a nice performance improvement if we use at least 4 cores</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">ci_profile_no_parent_0</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"profile"</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"k_parent_sink"</span>, <span class="st">"k_parent_m1"</span>, <span class="st">"k_m1_sink"</span>, <span class="st">"sigma"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 1.496 0.172 0.968 </span> +<span class="r-in"><span class="va">ci_profile</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.456003640 1.027703e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.040762501 5.549764e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046786482 5.500879e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.003892605 6.702778e-03</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.535612399 3.985263e+00</span> +<span class="r-in"><span class="va">ci_quadratic_transformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ci_quadratic_transformed</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403841640 1.027931e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.041033378 5.596269e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046777902 5.511931e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.004012217 6.897547e-03</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.854918e+00</span> +<span class="r-in"><span class="va">ci_quadratic_untransformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"quadratic"</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ci_quadratic_untransformed</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403841645 102.79312449</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.040485331 0.05535491</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046611582 0.05494364</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.003835483 0.00668582</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.85491806</span> +<span class="r-in"><span class="co"># Against the expectation based on Bates and Watts (1988), the confidence</span></span> +<span class="r-in"><span class="co"># intervals based on the internal parameter transformation are less</span></span> +<span class="r-in"><span class="co"># congruent with the likelihood based intervals. Note the superiority of the</span></span> +<span class="r-in"><span class="co"># interval based on the untransformed fit for k_m1_sink</span></span> +<span class="r-in"><span class="va">rel_diffs_transformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_transformed</span> <span class="op">-</span> <span class="va">ci_profile</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile</span><span class="op">)</span></span> +<span class="r-in"><span class="va">rel_diffs_untransformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_untransformed</span> <span class="op">-</span> <span class="va">ci_profile</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile</span><span class="op">)</span></span> +<span class="r-in"><span class="va">rel_diffs_transformed</span> <span class="op"><</span> <span class="va">rel_diffs_untransformed</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 FALSE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink TRUE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 TRUE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink FALSE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> sigma FALSE FALSE</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">signif</a></span><span class="op">(</span><span class="va">rel_diffs_transformed</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 0.000541 0.000222</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.006650 0.008380</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.000183 0.002010</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.030700 0.029100</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 0.055000 0.032700</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">signif</a></span><span class="op">(</span><span class="va">rel_diffs_untransformed</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 0.000541 0.000222</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.006800 0.002570</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.003740 0.001180</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.014700 0.002530</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 0.055000 0.032700</span> +<span class="r-in"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Investigate a case with formation fractions</span></span> +<span class="r-in"><span class="va">f_d_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ci_profile_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"profile"</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> +<span class="r-in"><span class="va">ci_profile_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.456003640 1.027703e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090911032 1.071578e-01</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.003892606 6.702775e-03</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.471328495 5.611550e-01</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.535612399 3.985263e+00</span> +<span class="r-in"><span class="va">ci_quadratic_transformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ci_quadratic_transformed_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403833578 102.79311649</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090823771 0.10725430</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.004012219 0.00689755</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.469118824 0.55959615</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.85491806</span> +<span class="r-in"><span class="va">ci_quadratic_untransformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ci_quadratic_untransformed_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403833583 1.027931e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090491913 1.069035e-01</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.003835485 6.685823e-03</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.469113477 5.598387e-01</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.854918e+00</span> +<span class="r-in"><span class="va">rel_diffs_transformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_transformed_ff</span> <span class="op">-</span> <span class="va">ci_profile_ff</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile_ff</span><span class="op">)</span></span> +<span class="r-in"><span class="va">rel_diffs_untransformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_untransformed_ff</span> <span class="op">-</span> <span class="va">ci_profile_ff</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile_ff</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># While the confidence interval for the parent rate constant is closer to</span></span> +<span class="r-in"><span class="co"># the profile based interval when using the internal parameter</span></span> +<span class="r-in"><span class="co"># transformation, the interval for the metabolite rate constant is 'better</span></span> +<span class="r-in"><span class="co"># without internal parameter transformation.</span></span> +<span class="r-in"><span class="va">rel_diffs_transformed_ff</span> <span class="op"><</span> <span class="va">rel_diffs_untransformed_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 FALSE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent TRUE TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 FALSE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 TRUE FALSE</span> +<span class="r-out co"><span class="r-pr">#></span> sigma TRUE FALSE</span> +<span class="r-in"><span class="va">rel_diffs_transformed_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 0.0005408690 0.0002217233</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0009598532 0.0009001864</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0307283041 0.0290588361</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.0046881769 0.0027780063</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 0.0550252516 0.0327066836</span> +<span class="r-in"><span class="va">rel_diffs_untransformed_ff</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 0.0005408689 0.0002217232</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0046102156 0.0023732281</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0146740690 0.0025291820</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.0046995211 0.0023457712</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 0.0550252516 0.0327066836</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The profiling for the following fit does not finish in a reasonable time,</span></span> +<span class="r-in"><span class="co"># therefore we use the quadratic approximation</span></span> +<span class="r-in"><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">DFOP_par_c</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> +<span class="r-in"><span class="va">f_tc_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>, <span class="va">DFOP_par_c</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> +<span class="r-in"> error_model_algorithm <span class="op">=</span> <span class="st">"direct"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_tc_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 94.596039609 106.19954892</span> +<span class="r-out co"><span class="r-pr">#></span> k_M1 0.037605368 0.04490762</span> +<span class="r-out co"><span class="r-pr">#></span> k_M2 0.008568731 0.01087676</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.021462489 0.62023882</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 0.015165617 0.37975348</span> +<span class="r-out co"><span class="r-pr">#></span> k1 0.273897348 0.33388101</span> +<span class="r-out co"><span class="r-pr">#></span> k2 0.018614554 0.02250378</span> +<span class="r-out co"><span class="r-pr">#></span> g 0.671943411 0.73583305</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.251283495 0.83992077</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.040411024 0.07662008</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_tc_2</span>, <span class="st">"parent_0"</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 94.59604 106.1995</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a 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-72,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Create degradation functions for known analytical solutions</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/create_deg_func.R'><code>R/create_deg_func.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/create_deg_func.R" class="external-link"><code>R/create_deg_func.R</code></a></small> <div class="hidden name"><code>create_deg_func.Rd</code></div> </div> @@ -147,83 +86,83 @@ <p>Create degradation functions for known analytical solutions</p> </div> - <pre class="usage"><span class='fu'>create_deg_func</span><span class='op'>(</span><span class='va'>spec</span>, use_of_ff <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"min"</span>, <span class='st'>"max"</span><span class='op'>)</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>spec</th> - <td><p>List of model specifications as contained in mkinmod objects</p></td> - </tr> - <tr> - <th>use_of_ff</th> - <td><p>Minimum or maximum use of formation fractions</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">create_deg_func</span><span class="op">(</span><span class="va">spec</span>, use_of_ff <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"min"</span>, <span class="st">"max"</span><span class="op">)</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>spec</dt> +<dd><p>List of model specifications as contained in mkinmod objects</p></dd> +<dt>use_of_ff</dt> +<dd><p>Minimum or maximum use of formation fractions</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Degradation function to be attached to mkinmod objects</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>FOCUS_D</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span> <span class='co'># to avoid warnings</span> -<span class='va'>fit_1</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"analytical"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>fit_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='co'># \dontrun{</span> -<span class='kw'>if</span> <span class='op'>(</span><span class='kw'><a href='https://rdrr.io/r/base/library.html'>require</a></span><span class='op'>(</span><span class='va'><a href='http://rbenchmark.googlecode.com'>rbenchmark</a></span><span class='op'>)</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/pkg/rbenchmark/man/benchmark.html'>benchmark</a></span><span class='op'>(</span> - analytical <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"analytical"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - deSolve <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - replications <span class='op'>=</span> <span class='fl'>2</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Loading required package: rbenchmark</span></div><div class='output co'>#> test replications elapsed relative user.self sys.self user.child -#> 1 analytical 2 0.389 1.000 0.389 0 0 -#> 2 deSolve 2 0.690 1.774 0.690 0 0 -#> sys.child -#> 1 0 -#> 2 0</div><div class='input'> <span class='va'>DFOP_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/pkg/rbenchmark/man/benchmark.html'>benchmark</a></span><span class='op'>(</span> - analytical <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>DFOP_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"analytical"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - deSolve <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>DFOP_SFO</span>, <span class='va'>FOCUS_D</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - replications <span class='op'>=</span> <span class='fl'>2</span><span class='op'>)</span> -</div><div class='output co'>#> test replications elapsed relative user.self sys.self user.child -#> 1 analytical 2 0.817 1.000 0.818 0 0 -#> 2 deSolve 2 1.591 1.947 1.591 0 0 -#> sys.child -#> 1 0 -#> 2 0</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># to avoid warnings</span></span> +<span class="r-in"><span class="va">fit_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span> +<span class="r-in"> analytical <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> deSolve <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> replications <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Loading required package: rbenchmark</span> +<span class="r-out co"><span class="r-pr">#></span> test replications elapsed relative user.self sys.self user.child</span> +<span class="r-out co"><span class="r-pr">#></span> 1 analytical 2 0.446 1.000 0.446 0 0</span> +<span class="r-out co"><span class="r-pr">#></span> 2 deSolve 2 0.756 1.695 0.756 0 0</span> +<span class="r-out co"><span class="r-pr">#></span> sys.child</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0</span> +<span class="r-in"> <span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span> +<span class="r-in"> analytical <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> deSolve <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> replications <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> test replications elapsed relative user.self sys.self user.child</span> +<span class="r-out co"><span class="r-pr">#></span> 1 analytical 2 0.896 1.000 0.896 0 0</span> +<span class="r-out co"><span class="r-pr">#></span> 2 deSolve 2 1.685 1.881 1.685 0 0</span> +<span class="r-out co"><span class="r-pr">#></span> sys.child</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/dimethenamid_2018-1.png b/docs/reference/dimethenamid_2018-1.png Binary files differnew file mode 100644 index 00000000..338076a5 --- /dev/null +++ b/docs/reference/dimethenamid_2018-1.png diff --git a/docs/reference/dimethenamid_2018-2.png b/docs/reference/dimethenamid_2018-2.png Binary files differnew file mode 100644 index 00000000..1f41a3a8 --- /dev/null +++ b/docs/reference/dimethenamid_2018-2.png diff --git a/docs/reference/dimethenamid_2018.html b/docs/reference/dimethenamid_2018.html index 542599da..374d2287 100644 --- a/docs/reference/dimethenamid_2018.html +++ b/docs/reference/dimethenamid_2018.html @@ -1,72 +1,17 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018 — dimethenamid_2018 • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" 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property="og:description" content="The datasets were extracted from the active substance evaluation dossier +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018 — dimethenamid_2018 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script 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src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018 — dimethenamid_2018"><meta property="og:description" content="The datasets were extracted from the active substance evaluation dossier published by EFSA. Kinetic evaluations shown for these datasets are intended to illustrate and advance kinetic modelling. The fact that these data and some results are shown here does not imply a license to use them in the context of pesticide registrations, as the use of the data may be -constrained by data protection regulations." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +constrained by data protection regulations."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -77,13 +22,12 @@ constrained by data protection regulations." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -92,8 +36,7 @@ constrained by data protection regulations." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -103,6 +46,9 @@ constrained by data protection regulations." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -117,34 +63,27 @@ constrained by data protection regulations." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/dimethenamid_2018.R'><code>R/dimethenamid_2018.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/dimethenamid_2018.R" class="external-link"><code>R/dimethenamid_2018.R</code></a></small> <div class="hidden name"><code>dimethenamid_2018.Rd</code></div> </div> @@ -157,75 +96,637 @@ context of pesticide registrations, as the use of the data may be constrained by data protection regulations.</p> </div> - <pre class="usage"><span class='va'>dimethenamid_2018</span></pre> - - - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> - - <p>An <a href='mkindsg.html'>mkindsg</a> object grouping seven datasets with some meta information</p> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">dimethenamid_2018</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>An <a href="mkindsg.html">mkindsg</a> object grouping seven datasets with some meta information</p> + </div> + <div id="source"> + <h2>Source</h2> <p>Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria (2018) Renewal Assessment Report Dimethenamid-P Volume 3 - B.8 Environmental fate and behaviour Rev. 2 - November 2017 -<a href='https://open.efsa.europa.eu'>https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a></p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - +<a href="https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a></p> + </div> + <div id="details"> + <h2>Details</h2> <p>The R code used to create this data object is installed with this package in the 'dataset_generation' directory. In the code, page numbers are given for specific pieces of information in the comments.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>dimethenamid_2018</span><span class='op'>)</span> -</div><div class='output co'>#> <mkindsg> holding 7 mkinds objects -#> Title $title: Aerobic soil degradation data on dimethenamid-P from the EU assessment in 2018 -#> Occurrence of observed compounds $observed_n: -#> DMTAP M23 M27 M31 DMTA -#> 3 7 7 7 4 -#> Time normalisation factors $f_time_norm: -#> [1] 1.0000000 0.9706477 1.2284784 1.2284784 0.6233856 0.7678922 0.6733938 -#> Meta information $meta: -#> study usda_soil_type study_moisture_ref_type rel_moisture -#> Calke Unsworth 2014 Sandy loam pF2 1.00 -#> Borstel Staudenmaier 2009 Sand pF1 0.50 -#> Elliot 1 Wendt 1997 Clay loam pF2.5 0.75 -#> Elliot 2 Wendt 1997 Clay loam pF2.5 0.75 -#> Flaach König 1996 Sandy clay loam pF1 0.40 -#> BBA 2.2 König 1995 Loamy sand pF1 0.40 -#> BBA 2.3 König 1995 Sandy loam pF1 0.40 -#> study_ref_moisture temperature -#> Calke NA 20 -#> Borstel 23.00 20 -#> Elliot 1 33.37 23 -#> Elliot 2 33.37 23 -#> Flaach NA 20 -#> BBA 2.2 NA 20 -#> BBA 2.3 NA 20</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 7 mkinds objects</span> +<span class="r-out co"><span class="r-pr">#></span> Title $title: Aerobic soil degradation data on dimethenamid-P from the EU assessment in 2018 </span> +<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> +<span class="r-out co"><span class="r-pr">#></span> DMTAP M23 M27 M31 DMTA </span> +<span class="r-out co"><span class="r-pr">#></span> 3 7 7 7 4 </span> +<span class="r-out co"><span class="r-pr">#></span> Time normalisation factors $f_time_norm:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1.0000000 0.9706477 1.2284784 1.2284784 0.6233856 0.7678922 0.6733938</span> +<span class="r-out co"><span class="r-pr">#></span> Meta information $meta:</span> +<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type rel_moisture</span> +<span class="r-out co"><span class="r-pr">#></span> Calke Unsworth 2014 Sandy loam pF2 1.00</span> +<span class="r-out co"><span class="r-pr">#></span> Borstel Staudenmaier 2009 Sand pF1 0.50</span> +<span class="r-out co"><span class="r-pr">#></span> Elliot 1 Wendt 1997 Clay loam pF2.5 0.75</span> +<span class="r-out co"><span class="r-pr">#></span> Elliot 2 Wendt 1997 Clay loam pF2.5 0.75</span> +<span class="r-out co"><span class="r-pr">#></span> Flaach König 1996 Sandy clay loam pF1 0.40</span> +<span class="r-out co"><span class="r-pr">#></span> BBA 2.2 König 1995 Loamy sand pF1 0.40</span> +<span class="r-out co"><span class="r-pr">#></span> BBA 2.3 König 1995 Sandy loam pF1 0.40</span> +<span class="r-out co"><span class="r-pr">#></span> study_ref_moisture temperature</span> +<span class="r-out co"><span class="r-pr">#></span> Calke NA 20</span> +<span class="r-out co"><span class="r-pr">#></span> Borstel 23.00 20</span> +<span class="r-out co"><span class="r-pr">#></span> Elliot 1 33.37 23</span> +<span class="r-out co"><span class="r-pr">#></span> Elliot 2 33.37 23</span> +<span class="r-out co"><span class="r-pr">#></span> Flaach NA 20</span> +<span class="r-out co"><span class="r-pr">#></span> BBA 2.2 NA 20</span> +<span class="r-out co"><span class="r-pr">#></span> BBA 2.3 NA 20</span> +<span class="r-in"><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> +<span class="r-in"> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span> +<span class="r-in"> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span> +<span class="r-in"> <span class="va">ds_i</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">dfop_sfo3_plus</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> DMTA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M23 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M27 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M31 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-in"><span class="va">f_dmta_mkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO3+"</span> <span class="op">=</span> <span class="va">dfop_sfo3_plus</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">dmta_ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="nlmixr.mmkin.html">nlmixr_model</a></span><span class="op">(</span><span class="va">f_dmta_mkin_tc</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> With est = 'saem', a different error model is required for each observed variableChanging the error model to 'obs_tc' (Two-component error for each observed variable)</span> +<span class="r-out co"><span class="r-pr">#></span> function () </span> +<span class="r-out co"><span class="r-pr">#></span> {</span> +<span class="r-out co"><span class="r-pr">#></span> ini({</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 = 99</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 ~ 2.3</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 = -3.9</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 ~ 0.55</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 = -4.3</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 ~ 0.86</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 = -4.2</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 ~ 0.75</span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 = -2.2</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 ~ 0.9</span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 = -3.8</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 ~ 1.6</span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis = 0.44</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis ~ 3.1</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis = -2.1</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis ~ 0.3</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis = -2.2</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis ~ 0.3</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis = -2.1</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis ~ 0.3</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_DMTA = 0.7</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_DMTA = 0.026</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_M23 = 0.7</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_M23 = 0.026</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_M27 = 0.7</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_M27 = 0.026</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_M31 = 0.7</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_M31 = 0.026</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> model({</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0_model = DMTA_0 + eta.DMTA_0</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA(0) = DMTA_0_model</span> +<span class="r-out co"><span class="r-pr">#></span> k_M23 = exp(log_k_M23 + eta.log_k_M23)</span> +<span class="r-out co"><span class="r-pr">#></span> k_M27 = exp(log_k_M27 + eta.log_k_M27)</span> +<span class="r-out co"><span class="r-pr">#></span> k_M31 = exp(log_k_M31 + eta.log_k_M31)</span> +<span class="r-out co"><span class="r-pr">#></span> k1 = exp(log_k1 + eta.log_k1)</span> +<span class="r-out co"><span class="r-pr">#></span> k2 = exp(log_k2 + eta.log_k2)</span> +<span class="r-out co"><span class="r-pr">#></span> g = expit(g_qlogis + eta.g_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1 = expit(f_DMTA_tffm0_1_qlogis + eta.f_DMTA_tffm0_1_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2 = expit(f_DMTA_tffm0_2_qlogis + eta.f_DMTA_tffm0_2_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3 = expit(f_DMTA_tffm0_3_qlogis + eta.f_DMTA_tffm0_3_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M23 = f_DMTA_tffm0_1</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M27 = f_DMTA_tffm0_2 * (1 - f_DMTA_tffm0_1)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M31 = f_DMTA_tffm0_3 * (1 - f_DMTA_tffm0_2) * </span> +<span class="r-out co"><span class="r-pr">#></span> (1 - f_DMTA_tffm0_1)</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(DMTA) = -((k1 * g * exp(-k1 * time) + k2 * (1 - </span> +<span class="r-out co"><span class="r-pr">#></span> g) * exp(-k2 * time))/(g * exp(-k1 * time) + (1 - </span> +<span class="r-out co"><span class="r-pr">#></span> g) * exp(-k2 * time))) * DMTA</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(M23) = +f_DMTA_to_M23 * ((k1 * g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> k2 * (1 - g) * exp(-k2 * time))/(g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> (1 - g) * exp(-k2 * time))) * DMTA - k_M23 * M23</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(M27) = +f_DMTA_to_M27 * ((k1 * g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> k2 * (1 - g) * exp(-k2 * time))/(g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> (1 - g) * exp(-k2 * time))) * DMTA - k_M27 * M27 + </span> +<span class="r-out co"><span class="r-pr">#></span> k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(M31) = +f_DMTA_to_M31 * ((k1 * g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> k2 * (1 - g) * exp(-k2 * time))/(g * exp(-k1 * time) + </span> +<span class="r-out co"><span class="r-pr">#></span> (1 - g) * exp(-k2 * time))) * DMTA - k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA ~ add(sigma_low_DMTA) + prop(rsd_high_DMTA)</span> +<span class="r-out co"><span class="r-pr">#></span> M23 ~ add(sigma_low_M23) + prop(rsd_high_M23)</span> +<span class="r-out co"><span class="r-pr">#></span> M27 ~ add(sigma_low_M27) + prop(rsd_high_M27)</span> +<span class="r-out co"><span class="r-pr">#></span> M31 ~ add(sigma_low_M31) + prop(rsd_high_M31)</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> }</span> +<span class="r-out co"><span class="r-pr">#></span> <environment: 0x555560091f40></span> +<span class="r-in"><span class="co"># The focei fit takes about four minutes on my system</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="va">f_dmta_nlmixr_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_dmta_mkin_tc</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu">nlmixr</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">500</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:02 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:04 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:01 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:08 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:07 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:07 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:00 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> [====|====|====|====|====|====|====|====|====|====] 0:00:00 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> RxODE 1.1.4 using 8 threads (see ?getRxThreads)</span> +<span class="r-msg co"><span class="r-pr">#></span> no cache: create with `rxCreateCache()`</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | DMTA_0 | log_k_M23 | log_k_M27 | log_k_M31 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k1 | log_k2 | g_qlogis |f_DMTA_tffm0_1_qlogis |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................|f_DMTA_tffm0_2_qlogis |f_DMTA_tffm0_3_qlogis | sigma_low | rsd_high |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o5 | o6 | o7 | o8 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o9 | o10 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>S matrix non-positive definite</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 553.721 10.570 564.258 </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_dmta_nlmixr_focei</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> nlmixr version used for fitting: 2.0.6 </span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:27:22 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:27:22 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * DMTA</span> +<span class="r-out co"><span class="r-pr">#></span> d_M23/dt = + f_DMTA_to_M23 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M23 * M23</span> +<span class="r-out co"><span class="r-pr">#></span> d_M27/dt = + f_DMTA_to_M27 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M27 * M27 + k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> d_M31/dt = + f_DMTA_to_M31 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 563 observations of 4 variable(s) grouped in 6 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Degradation model predictions using RxODE</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted in 564.08 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 log_k_M23 log_k_M27 log_k_M31 f_DMTA_ilr_1 f_DMTA_ilr_2 </span> +<span class="r-out co"><span class="r-pr">#></span> 98.7132 -3.9216 -4.3306 -4.2442 0.1376 0.1388 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 log_k1 log_k2 g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> -1.7554 -2.2352 -3.7758 0.4363 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for error model parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low rsd_high </span> +<span class="r-out co"><span class="r-pr">#></span> 0.70012 0.02577 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood calculated by focei </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 1857 1952 -906.5</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 98.0116 95.243 100.780</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -4.0184 -5.213 -2.824</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -4.2033 -5.013 -3.394</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -4.1728 -4.999 -3.347</span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.4831 -3.398 -1.568</span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 -3.8423 -5.450 -2.235</span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis 0.4682 -2.188 3.124</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis -2.0823 -2.591 -1.574</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis -2.1265 -2.686 -1.567</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis -2.0795 -2.735 -1.424</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 lg__M23 lg__M27 lg__M31 log_k1 log_k2 g_qlogs</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -0.0154 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -0.0164 0.0031 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -0.0131 0.0018 0.0541 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 -0.0306 0.0045 0.0019 0.0011 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 0.0527 -0.0043 -0.0037 -0.0003 0.0375 </span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.1005 0.0076 0.0074 0.0013 0.0910 0.1151 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis -0.0308 0.0362 0.0024 0.0021 0.0058 -0.0070 0.0145</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis -0.0309 0.0062 0.0353 -0.0229 0.0047 -0.0082 0.0146</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis -0.0308 0.0061 0.0419 0.0547 0.0033 -0.0055 0.0104</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_0_1 f_DMTA_0_2</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 </span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis 0.0118 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis 0.0086 -0.0057 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects (omega):</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 eta.log_k_M23 eta.log_k_M27 eta.log_k_M31</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 4.224 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.000 1.041 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.000 0.000 0.4609 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.000 0.000 0.0000 0.4728</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 eta.log_k2 eta.g_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.635 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.000 1.662 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.000 0.000 4.36</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.000 0.000 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis eta.f_DMTA_tffm0_2_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.1909 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.0000 0.2232</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.3149</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low rsd_high </span> +<span class="r-out co"><span class="r-pr">#></span> 0.82408 0.03045 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 98.01163 95.243379 100.77988</span> +<span class="r-out co"><span class="r-pr">#></span> k_M23 0.01798 0.005443 0.05940</span> +<span class="r-out co"><span class="r-pr">#></span> k_M27 0.01495 0.006652 0.03358</span> +<span class="r-out co"><span class="r-pr">#></span> k_M31 0.01541 0.006746 0.03520</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M23 0.11083 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M27 0.09474 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M31 0.08827 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> k1 0.08348 0.033429 0.20848</span> +<span class="r-out co"><span class="r-pr">#></span> k2 0.02144 0.004296 0.10704</span> +<span class="r-out co"><span class="r-pr">#></span> g 0.61496 0.100857 0.95788</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> +<span class="r-out co"><span class="r-pr">#></span> ff</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M23 0.11083</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M27 0.09474</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M31 0.08827</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_sink 0.70616</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA 12.96 64.24 19.34 8.303 32.32</span> +<span class="r-out co"><span class="r-pr">#></span> M23 38.55 128.06 NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> M27 46.38 154.06 NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> M31 44.98 149.43 NA NA NA</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_dmta_nlmixr_focei</span><span class="op">)</span></span> +<span class="r-plt img"><img src="dimethenamid_2018-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># Using saemix takes about 18 minutes</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="va">f_dmta_saemix</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_dmta_mkin_tc</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> DINTDY- T (=R1) illegal </span> +<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 115.507</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> T not in interval TCUR - HU (= R1) to TCUR (=R2) </span> +<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 112.133, R2 = 113.577</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> DLSODA- At T (=R1), too much accuracy requested </span> +<span class="r-out co"><span class="r-pr">#></span> for precision of machine.. See TOLSF (=R2) </span> +<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 55.3899, R2 = nan</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in out[available, var]:</span> (subscript) logical subscript too long</span> +<span class="r-msg co"><span class="r-pr">#></span> Timing stopped at: 12.58 0 12.58</span> +<span class="r-msg co"><span class="r-pr">#></span> Timing stopped at: 12.99 0.008 13</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># nlmixr with est = "saem" is pretty fast with default iteration numbers, most</span></span> +<span class="r-in"><span class="co"># of the time (about 2.5 minutes) is spent for calculating the log likelihood at the end</span></span> +<span class="r-in"><span class="co"># The likelihood calculated for the nlmixr fit is much lower than that found by saemix</span></span> +<span class="r-in"><span class="co"># Also, the trace plot and the plot of the individual predictions is not</span></span> +<span class="r-in"><span class="co"># convincing for the parent. It seems we are fitting an overparameterised</span></span> +<span class="r-in"><span class="co"># model, so the result we get strongly depends on starting parameters and control settings.</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="va">f_dmta_nlmixr_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_dmta_mkin_tc</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu">nlmixr</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">500</span>, logLik <span class="op">=</span> <span class="cn">TRUE</span>, nmc <span class="op">=</span> <span class="fl">9</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> With est = 'saem', a different error model is required for each observed variableChanging the error model to 'obs_tc' (Two-component error for each observed variable)</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> 1: 98.7179 -3.4492 -3.2592 -3.6952 -2.1629 -2.7824 0.8990 -2.8080 -2.7380 -2.8041 2.7789 0.6848 0.8170 0.7125 0.8550 1.5200 2.9882 0.3073 0.2850 0.2877 4.0480 0.4153 4.5214 0.3775 4.4419 0.4181 3.7069 0.5935</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 97.8519 -4.3891 -4.0888 -4.1247 -2.9246 -4.2755 2.6294 -2.1212 -2.1380 -2.0739 3.1293 1.2665 0.2763 0.3429 0.5743 1.5561 4.4991 0.1499 0.1551 0.3103 0.9514 0.0341 0.4846 0.1068 0.6597 0.0767 0.7836 0.0360</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 785.825 3.841 153.598 </span> +<span class="r-in"><span class="fu">traceplot</span><span class="op">(</span><span class="va">f_dmta_nlmixr_saem</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in traceplot(f_dmta_nlmixr_saem$nm):</span> could not find function "traceplot"</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_dmta_nlmixr_saem</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> nlmixr version used for fitting: 2.0.6 </span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:30:09 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:30:09 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * DMTA</span> +<span class="r-out co"><span class="r-pr">#></span> d_M23/dt = + f_DMTA_to_M23 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M23 * M23</span> +<span class="r-out co"><span class="r-pr">#></span> d_M27/dt = + f_DMTA_to_M27 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M27 * M27 + k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> d_M31/dt = + f_DMTA_to_M31 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * DMTA - k_M31 * M31</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 563 observations of 4 variable(s) grouped in 6 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Degradation model predictions using RxODE</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted in 153.313 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 log_k_M23 log_k_M27 log_k_M31 f_DMTA_ilr_1 f_DMTA_ilr_2 </span> +<span class="r-out co"><span class="r-pr">#></span> 98.7132 -3.9216 -4.3306 -4.2442 0.1376 0.1388 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 log_k1 log_k2 g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> -1.7554 -2.2352 -3.7758 0.4363 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for error model parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_DMTA rsd_high_DMTA sigma_low_M23 rsd_high_M23 sigma_low_M27 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.70012 0.02577 0.70012 0.02577 0.70012 </span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_M27 sigma_low_M31 rsd_high_M31 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.02577 0.70012 0.02577 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood calculated by focei </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 1966 2088 -955.2</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 97.852 95.86386 99.840</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -4.389 -5.35084 -3.427</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -4.089 -4.54432 -3.633</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -4.125 -4.63280 -3.617</span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.925 -3.54158 -2.308</span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 -4.275 -5.81760 -2.733</span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis 2.629 -0.01785 5.277</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis -2.121 -2.44462 -1.798</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis -2.138 -2.47804 -1.798</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis -2.074 -2.53581 -1.612</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 lg__M23 lg__M27 lg__M31 log_k1 log_k2 g_qlogs</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -0.0164 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -0.0267 0.0028 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -0.0179 0.0023 0.0755 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 0.0385 -0.0034 -0.0054 -0.0029 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 0.0381 0.0115 0.0087 0.0093 0.0786 </span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.0656 0.0021 0.0051 0.0001 -0.1177 -0.4389 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis -0.0604 0.0554 0.0054 0.0039 -0.0082 -0.0022 0.0119</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis -0.0601 0.0091 0.0577 -0.0350 -0.0081 -0.0057 0.0137</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis -0.0515 0.0083 0.0569 0.0729 -0.0059 0.0005 0.0073</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_0_1 f_DMTA_0_2</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M31 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 </span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 </span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis 0.0167 </span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_3_qlogis 0.0145 -0.0060 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects (omega):</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 eta.log_k_M23 eta.log_k_M27 eta.log_k_M31</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 3.129 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.000 1.266 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.000 0.000 0.2763 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.000 0.000 0.0000 0.3429</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 eta.log_k2 eta.g_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.5743 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.0000 1.556 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.0000 0.000 4.499</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.0000 0.000 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis eta.f_DMTA_tffm0_2_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.1499 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.0000 0.1551</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M31 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k1 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k2 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.g_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_3_qlogis 0.3103</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_DMTA rsd_high_DMTA sigma_low_M23 rsd_high_M23 sigma_low_M27 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.95135 0.03412 0.48455 0.10682 0.65969 </span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high_M27 sigma_low_M31 rsd_high_M31 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.07670 0.78365 0.03598 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 97.85189 95.863863 99.83992</span> +<span class="r-out co"><span class="r-pr">#></span> k_M23 0.01241 0.004744 0.03247</span> +<span class="r-out co"><span class="r-pr">#></span> k_M27 0.01676 0.010627 0.02643</span> +<span class="r-out co"><span class="r-pr">#></span> k_M31 0.01617 0.009727 0.02687</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M23 0.10705 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M27 0.09417 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M31 0.08919 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> k1 0.05369 0.028968 0.09950</span> +<span class="r-out co"><span class="r-pr">#></span> k2 0.01391 0.002975 0.06500</span> +<span class="r-out co"><span class="r-pr">#></span> g 0.93273 0.495538 0.99492</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> +<span class="r-out co"><span class="r-pr">#></span> ff</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M23 0.10705</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M27 0.09417</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_M31 0.08919</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_sink 0.70959</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA 13.81 49.3 14.84 12.91 49.85</span> +<span class="r-out co"><span class="r-pr">#></span> M23 55.85 185.5 NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> M27 41.36 137.4 NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> M31 42.87 142.4 NA NA NA</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_dmta_nlmixr_saem</span><span class="op">)</span></span> +<span class="r-plt img"><img src="dimethenamid_2018-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/endpoints.html b/docs/reference/endpoints.html index bfe030b0..1476eed8 100644 --- a/docs/reference/endpoints.html +++ b/docs/reference/endpoints.html @@ -1,73 +1,18 @@ 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endpoints"><meta property="og:description" content="This function calculates DT50 and DT90 values as well as formation fractions from kinetic models fitted with mkinfit. If the SFORB model was specified for one of the parents or metabolites, the Eigenvalues are returned. These are equivalent to the rate constants of the DFOP model, but with the -advantage that the SFORB model can also be used for metabolites." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +advantage that the SFORB model can also be used for metabolites."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -78,13 +23,12 @@ advantage that the SFORB model can also be used for metabolites." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -93,8 +37,7 @@ advantage that the SFORB model can also be used for metabolites." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -104,6 +47,9 @@ advantage that the SFORB model can also be used for metabolites." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -118,35 +64,28 @@ advantage that the SFORB model can also be used for metabolites." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to calculate endpoints for further use from kinetic models fitted with mkinfit</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/endpoints.R'><code>R/endpoints.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/endpoints.R" class="external-link"><code>R/endpoints.R</code></a></small> <div class="hidden name"><code>endpoints.Rd</code></div> </div> @@ -158,93 +97,96 @@ are equivalent to the rate constants of the DFOP model, but with the advantage that the SFORB model can also be used for metabolites.</p> </div> - <pre class="usage"><span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">endpoints</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>fit</th> - <td><p>An object of class <a href='mkinfit.html'>mkinfit</a> or <a href='nlme.mmkin.html'>nlme.mmkin</a> -or another object that has list components -mkinmod containing an <a href='mkinmod.html'>mkinmod</a> degradation model, and two numeric vectors, + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>fit</dt> +<dd><p>An object of class <a href="mkinfit.html">mkinfit</a>, <a href="nlme.mmkin.html">nlme.mmkin</a>, <a href="saem.html">saem.mmkin</a> or +<a href="nlmixr.mmkin.html">nlmixr.mmkin</a>. Or another object that has list components +mkinmod containing an <a href="mkinmod.html">mkinmod</a> degradation model, and two numeric vectors, bparms.optim and bparms.fixed, that contain parameter values -for that model.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +for that model.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A list with a matrix of dissipation times named distimes, and, if applicable, a vector of formation fractions named ff and, if the SFORB model was in use, a vector of eigenvalues of these SFORB models, equivalent to DFOP rate constants</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>Additional DT50 values are calculated from the FOMC DT90 and k1 and k2 from HS and DFOP, as well as from Eigenvalues b1 and b2 of any SFORB models</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - - <p>The function is used internally by <a href='summary.mkinfit.html'>summary.mkinfit</a> -and <a href='summary.nlme.mmkin.html'>summary.nlme.mmkin</a></p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="note"> + <h2>Note</h2> + <p>The function is used internally by <a href="summary.mkinfit.html">summary.mkinfit</a>, +<a href="summary.nlme.mmkin.html">summary.nlme.mmkin</a> and <a href="summary.saem.mmkin.html">summary.saem.mmkin</a>.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> $distimes -#> DT50 DT90 DT50back -#> parent 1.785233 15.1479 4.559973 -#> </div><div class='input'> <span class='co'># \dontrun{</span> - <span class='va'>fit_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit_2</span><span class='op'>)</span> -</div><div class='output co'>#> $distimes -#> DT50 DT90 DT50back DT50_k1 DT50_k2 -#> parent 1.886925 21.25106 6.397207 1.508293 38.83438 -#> </div><div class='input'> <span class='va'>fit_3</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFORB"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'>endpoints</span><span class='op'>(</span><span class='va'>fit_3</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_free -#> 1 -#> -#> $SFORB -#> parent_b1 parent_b2 -#> 0.4595574 0.0178488 -#> -#> $distimes -#> DT50 DT90 DT50back DT50_parent_b1 DT50_parent_b2 -#> parent 1.886925 21.25106 6.397208 1.508293 38.83438 -#> </div><div class='input'> <span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> +<span class="r-out co"><span class="r-pr">#></span> parent 1.785233 15.1479 4.559973</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="r-out co"><span class="r-pr">#></span> parent 1.886925 21.25106 6.397207 1.508293 38.83438</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="va">fit_3</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit_3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_free </span> +<span class="r-out co"><span class="r-pr">#></span> 1 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $SFORB</span> +<span class="r-out co"><span class="r-pr">#></span> parent_b1 parent_b2 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.4595574 0.0178488 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_parent_b1 DT50_parent_b2</span> +<span class="r-out co"><span class="r-pr">#></span> parent 1.886925 21.25106 6.397208 1.508293 38.83438</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/experimental_data_for_UBA-1.png b/docs/reference/experimental_data_for_UBA-1.png Binary files differindex 5527c07f..b7b4d63b 100644 --- a/docs/reference/experimental_data_for_UBA-1.png +++ b/docs/reference/experimental_data_for_UBA-1.png diff --git a/docs/reference/experimental_data_for_UBA.html b/docs/reference/experimental_data_for_UBA.html index 4da8d6c3..862c63e4 100644 --- a/docs/reference/experimental_data_for_UBA.html +++ b/docs/reference/experimental_data_for_UBA.html @@ -1,46 +1,5 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - 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Kinetic evaluations shown for these datasets are intended to illustrate and advance error model specifications. The fact that these data and some results are shown here do not imply a license to use them in the context of @@ -68,28 +27,14 @@ Dataset 11 is from the Renewal Assessment Report (RAR) for 2,4-D the exception of the day three sampling of metabolite A2, which was set to one half of the LOD reported to be 1% AR. Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl - (United Kingdom, 2014, p. 81)." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> + (United Kingdom, 2014, p. 81)."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -100,13 +45,12 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -115,8 +59,7 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -126,6 +69,9 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -140,30 +86,23 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Experimental datasets used for development and testing of error models</h1> @@ -203,30 +142,33 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl (United Kingdom, 2014, p. 81).</p> </div> - <pre class="usage"><span class='va'>experimental_data_for_UBA_2019</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">experimental_data_for_UBA_2019</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>A list containing twelve datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>, + each containing, among others, the following components</p><dl><dt><code>title</code></dt> +<dd><p>The name of the dataset, e.g. <code>Soil 1</code></p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>data</code></dt> +<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - <p>A list containing twelve datasets as an R6 class defined by <code><a href='mkinds.html'>mkinds</a></code>, - each containing, among others, the following components</p><dl> - <dt><code>title</code></dt><dd><p>The name of the dataset, e.g. <code>Soil 1</code></p></dd> - <dt><code>data</code></dt><dd><p>A data frame with the data in the form expected by <code><a href='mkinfit.html'>mkinfit</a></code></p></dd> -</dl> - - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> - +</dl></div> + <div id="source"> + <h2>Source</h2> <p>Austria (2015). Ethofumesate Renewal Assessment Report Volume 3 Annex B.8 (AS)</p> <p>Belgium (2014). Isofetamid (IKF-5411) Draft Assessment Report Volume 3 Annex B.8 (AS)</p> <p>France (2015). Imazamox Draft Renewal Assessment Report Volume 3 Annex B.8 (AS)</p> -<p>FOCUS (2014) “Generic guidance for Estimating Persistence and +<p>FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, + Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 - <a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> <p>Germany (2013). Renewal Assessment Report Glyphosate Volume 3 Annex B.8: Environmental Fate and Behaviour</p> <p>Hellas (2013). Renewal Assessment Report 2,4-D Volume 3 Annex B.8: Fate and behaviour in the @@ -236,70 +178,75 @@ Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl <p>United Kingdom (2014). Thifensulfuron-methyl - Annex B.8 (Volume 3) to the Report and Proposed Decision of the United Kingdom made to the European Commission under Regulation (EC) No. 1141/2010 for renewal of an active substance</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> - -<span class='co'># Model definitions</span> -<span class='va'>sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span> -<span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>dfop_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span> -<span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>sfo_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"A2"</span><span class='op'>)</span>, - A2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span> -<span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>dfop_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"A2"</span><span class='op'>)</span>, - A2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span> -<span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>d_1_2</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>1</span><span class='op'>:</span><span class='fl'>2</span><span class='op'>]</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>d_1_2</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"Soil"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>2</span><span class='op'>)</span> - - -<span class='va'>f_1_2_tc</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"DFOP-SFO-SFO"</span> <span class='op'>=</span> <span class='va'>dfop_sfo_sfo</span><span class='op'>)</span>, <span class='va'>d_1_2</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> - -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_1_2_tc</span>, resplot <span class='op'>=</span> <span class='st'>"errmod"</span><span class='op'>)</span> -</div><div class='img'><img src='experimental_data_for_UBA-1.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># }</span></div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Model definitions</span></span> +<span class="r-in"><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">sfo_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span> +<span class="r-in"> A2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">dfop_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span> +<span class="r-in"> A2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">d_1_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">2</span><span class="op">]</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">d_1_2</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Soil"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">2</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_1_2_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo_sfo</span><span class="op">)</span>, <span class="va">d_1_2</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_1_2_tc</span>, resplot <span class="op">=</span> <span class="st">"errmod"</span><span class="op">)</span></span> +<span class="r-plt img"><img src="experimental_data_for_UBA-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/f_time_norm_focus.html b/docs/reference/f_time_norm_focus.html index a0899ac8..4bec2bd5 100644 --- a/docs/reference/f_time_norm_focus.html +++ b/docs/reference/f_time_norm_focus.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Normalisation factors for aerobic soil degradation according to FOCUS guidance — f_time_norm_focus • mkin</title> - - -<!-- jquery --> -<script 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degradation according to FOCUS guidance — f_time_norm_focus"><meta property="og:description" content="Time step normalisation factors for aerobic soil degradation as described +in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Normalisation factors for aerobic soil degradation according to FOCUS guidance</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/f_time_norm_focus.R'><code>R/f_time_norm_focus.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/f_time_norm_focus.R" class="external-link"><code>R/f_time_norm_focus.R</code></a></small> <div class="hidden name"><code>f_time_norm_focus.Rd</code></div> </div> @@ -149,137 +88,121 @@ in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369)." /> in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369).</p> </div> - <pre class="usage"><span class='fu'>f_time_norm_focus</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for numeric</span> -<span class='fu'>f_time_norm_focus</span><span class='op'>(</span> - <span class='va'>object</span>, - moisture <span class='op'>=</span> <span class='cn'>NA</span>, - field_moisture <span class='op'>=</span> <span class='cn'>NA</span>, - temperature <span class='op'>=</span> <span class='va'>object</span>, - Q10 <span class='op'>=</span> <span class='fl'>2.58</span>, - walker <span class='op'>=</span> <span class='fl'>0.7</span>, - f_na <span class='op'>=</span> <span class='cn'>NA</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='co'># S3 method for mkindsg</span> -<span class='fu'>f_time_norm_focus</span><span class='op'>(</span> - <span class='va'>object</span>, - study_moisture_ref_source <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"auto"</span>, <span class='st'>"meta"</span>, <span class='st'>"focus"</span><span class='op'>)</span>, - Q10 <span class='op'>=</span> <span class='fl'>2.58</span>, - walker <span class='op'>=</span> <span class='fl'>0.7</span>, - f_na <span class='op'>=</span> <span class='cn'>NA</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for numeric</span> +<span class="fu">f_time_norm_focus</span><span class="op">(</span> + <span class="va">object</span>, + moisture <span class="op">=</span> <span class="cn">NA</span>, + field_moisture <span class="op">=</span> <span class="cn">NA</span>, + temperature <span class="op">=</span> <span class="va">object</span>, + Q10 <span class="op">=</span> <span class="fl">2.58</span>, + walker <span class="op">=</span> <span class="fl">0.7</span>, + f_na <span class="op">=</span> <span class="cn">NA</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="co"># S3 method for mkindsg</span> +<span class="fu">f_time_norm_focus</span><span class="op">(</span> + <span class="va">object</span>, + study_moisture_ref_source <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"meta"</span>, <span class="st">"focus"</span><span class="op">)</span>, + Q10 <span class="op">=</span> <span class="fl">2.58</span>, + walker <span class="op">=</span> <span class="fl">0.7</span>, + f_na <span class="op">=</span> <span class="cn">NA</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An object containing information used for the calculations</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Currently not used</p></td> - </tr> - <tr> - <th>moisture</th> - <td><p>Numeric vector of moisture contents in \% w/w</p></td> - </tr> - <tr> - <th>field_moisture</th> - <td><p>Numeric vector of moisture contents at field capacity -(pF2) in \% w/w</p></td> - </tr> - <tr> - <th>temperature</th> - <td><p>Numeric vector of temperatures in °C</p></td> - </tr> - <tr> - <th>Q10</th> - <td><p>The Q10 value used for temperature normalisation</p></td> - </tr> - <tr> - <th>walker</th> - <td><p>The Walker exponent used for moisture normalisation</p></td> - </tr> - <tr> - <th>f_na</th> - <td><p>The factor to use for NA values. If set to NA, only factors -for complete cases will be returned.</p></td> - </tr> - <tr> - <th>study_moisture_ref_source</th> - <td><p>Source for the reference value + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An object containing information used for the calculations</p></dd> +<dt>...</dt> +<dd><p>Currently not used</p></dd> +<dt>moisture</dt> +<dd><p>Numeric vector of moisture contents in \% w/w</p></dd> +<dt>field_moisture</dt> +<dd><p>Numeric vector of moisture contents at field capacity +(pF2) in \% w/w</p></dd> +<dt>temperature</dt> +<dd><p>Numeric vector of temperatures in °C</p></dd> +<dt>Q10</dt> +<dd><p>The Q10 value used for temperature normalisation</p></dd> +<dt>walker</dt> +<dd><p>The Walker exponent used for moisture normalisation</p></dd> +<dt>f_na</dt> +<dd><p>The factor to use for NA values. If set to NA, only factors +for complete cases will be returned.</p></dd> +<dt>study_moisture_ref_source</dt> +<dd><p>Source for the reference value used to calculate the study moisture. If 'auto', preference is given to a reference moisture given in the meta information, otherwise -the focus soil moisture for the soil class is used</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence +the focus soil moisture for the soil class is used</p></dd> +</dl></div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><a href='focus_soil_moisture.html'>focus_soil_moisture</a></p></div> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><a href="focus_soil_moisture.html">focus_soil_moisture</a></p></div> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='fu'>f_time_norm_focus</span><span class='op'>(</span><span class='fl'>25</span>, <span class='fl'>20</span>, <span class='fl'>25</span><span class='op'>)</span> <span class='co'># 1.37, compare FOCUS 2014 p. 184</span> -</div><div class='output co'>#> [1] 1.373956</div><div class='input'> -<span class='va'>D24_2014</span><span class='op'>$</span><span class='va'>meta</span> -</div><div class='output co'>#> study usda_soil_type study_moisture_ref_type -#> Mississippi Cohen 1991 Silt loam <NA> -#> Fayette Liu and Adelfinskaya 2011 Silt loam pF1 -#> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1 -#> Site E1 Liu and Adelfinskaya 2011 Loam pF1 -#> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1 -#> rel_moisture temperature -#> Mississippi NA 25 -#> Fayette 0.5 20 -#> RefSol 03-G 0.5 20 -#> Site E1 0.5 20 -#> Site I2 0.5 20</div><div class='input'><span class='co'># No moisture normalisation in the first dataset, so we use f_na = 1 to get</span> -<span class='co'># temperature only normalisation as in the EU evaluation</span> -<span class='fu'>f_time_norm_focus</span><span class='op'>(</span><span class='va'>D24_2014</span>, study_moisture_ref_source <span class='op'>=</span> <span class='st'>"focus"</span>, f_na <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -</div><div class='output co'>#> $time_norm was set to -#> [1] 1.6062378 0.7118732 0.7156063 0.7156063 0.8977124</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="fl">25</span>, <span class="fl">20</span>, <span class="fl">25</span><span class="op">)</span> <span class="co"># 1.37, compare FOCUS 2014 p. 184</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1.373956</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">D24_2014</span><span class="op">$</span><span class="va">meta</span></span> +<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type</span> +<span class="r-out co"><span class="r-pr">#></span> Mississippi Cohen 1991 Silt loam <NA></span> +<span class="r-out co"><span class="r-pr">#></span> Fayette Liu and Adelfinskaya 2011 Silt loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> Site E1 Liu and Adelfinskaya 2011 Loam pF1</span> +<span class="r-out co"><span class="r-pr">#></span> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1</span> +<span class="r-out co"><span class="r-pr">#></span> rel_moisture temperature</span> +<span class="r-out co"><span class="r-pr">#></span> Mississippi NA 25</span> +<span class="r-out co"><span class="r-pr">#></span> Fayette 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> Site E1 0.5 20</span> +<span class="r-out co"><span class="r-pr">#></span> Site I2 0.5 20</span> +<span class="r-in"><span class="co"># No moisture normalisation in the first dataset, so we use f_na = 1 to get</span></span> +<span class="r-in"><span class="co"># temperature only normalisation as in the EU evaluation</span></span> +<span class="r-in"><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="va">D24_2014</span>, study_moisture_ref_source <span class="op">=</span> <span class="st">"focus"</span>, f_na <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> $f_time_norm was (re)set to normalised values</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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The table assumes field capacity -corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar — focus_soil_moisture • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar — focus_soil_moisture"><meta property="og:description" content="The value were transcribed from p. 36. The table assumes field capacity +corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/focus_soil_moisture.R'><code>R/focus_soil_moisture.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/focus_soil_moisture.R" class="external-link"><code>R/focus_soil_moisture.R</code></a></small> <div class="hidden name"><code>focus_soil_moisture.Rd</code></div> </div> @@ -149,58 +88,60 @@ corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5." /> corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5.</p> </div> - <pre class="usage"><span class='va'>focus_soil_moisture</span></pre> - - - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">focus_soil_moisture</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> <p>A matrix with upper case USDA soil classes as row names, and water tension ('pF1', 'pF2', 'pF 2.5') as column names</p> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> - + </div> + <div id="source"> + <h2>Source</h2> <p>Anonymous (2014) Generic Guidance for Tier 1 FOCUS Ground Water Assessment -Version 2.2, May 2014 <a href='https://esdac.jrc.ec.europa.eu/projects/ground-water'>https://esdac.jrc.ec.europa.eu/projects/ground-water</a></p> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>focus_soil_moisture</span> -</div><div class='output co'>#> pF1 pF2 pF2.5 -#> Sand 24 12 7 -#> Loamy sand 24 14 9 -#> Sandy loam 27 19 15 -#> Sandy clay loam 28 22 18 -#> Clay loam 32 28 25 -#> Loam 31 25 21 -#> Silt loam 32 26 21 -#> Silty clay loam 34 30 27 -#> Silt 31 27 21 -#> Sandy clay 41 35 31 -#> Silty clay 44 40 36 -#> Clay 53 48 43</div></pre> +Version 2.2, May 2014 <a href="https://esdac.jrc.ec.europa.eu/projects/ground-water" class="external-link">https://esdac.jrc.ec.europa.eu/projects/ground-water</a></p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">focus_soil_moisture</span></span> +<span class="r-out co"><span class="r-pr">#></span> pF1 pF2 pF2.5</span> +<span class="r-out co"><span class="r-pr">#></span> Sand 24 12 7</span> +<span class="r-out co"><span class="r-pr">#></span> Loamy sand 24 14 9</span> +<span class="r-out co"><span class="r-pr">#></span> Sandy loam 27 19 15</span> +<span class="r-out co"><span class="r-pr">#></span> Sandy clay loam 28 22 18</span> +<span class="r-out co"><span class="r-pr">#></span> Clay loam 32 28 25</span> +<span class="r-out co"><span class="r-pr">#></span> Loam 31 25 21</span> +<span class="r-out co"><span class="r-pr">#></span> Silt loam 32 26 21</span> +<span class="r-out co"><span class="r-pr">#></span> Silty clay loam 34 30 27</span> +<span class="r-out co"><span class="r-pr">#></span> Silt 31 27 21</span> +<span class="r-out co"><span class="r-pr">#></span> Sandy clay 41 35 31</span> +<span class="r-out co"><span class="r-pr">#></span> Silty clay 44 40 36</span> +<span class="r-out co"><span class="r-pr">#></span> Clay 53 48 43</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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- - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -72,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Retrieve a degradation function from the mmkin namespace</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nlme.mmkin.R'><code>R/nlme.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.mmkin.R" class="external-link"><code>R/nlme.mmkin.R</code></a></small> <div class="hidden name"><code>get_deg_func.Rd</code></div> </div> @@ -147,39 +86,37 @@ <p>Retrieve a degradation function from the mmkin namespace</p> </div> - <pre class="usage"><span class='fu'>get_deg_func</span><span class='op'>(</span><span class='op'>)</span></pre> - - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">get_deg_func</span><span class="op">(</span><span class="op">)</span></code></pre></div> + </div> + <div id="value"> + <h2>Value</h2> <p>A function that was likely previously assigned from within nlme.mmkin</p> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/ilr.html b/docs/reference/ilr.html index 671faf5d..5322c41e 100644 --- a/docs/reference/ilr.html +++ b/docs/reference/ilr.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - 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- +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ transformations." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ transformations." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ transformations." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ transformations." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to perform isometric log-ratio transformation</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/ilr.R'><code>R/ilr.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/ilr.R" class="external-link"><code>R/ilr.R</code></a></small> <div class="hidden name"><code>ilr.Rd</code></div> </div> @@ -149,86 +88,97 @@ transformations." /> transformations.</p> </div> - <pre class="usage"><span class='fu'>ilr</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> - -<span class='fu'>invilr</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">ilr</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>A numeric vector. Naturally, the forward transformation is only -sensible for vectors with all elements being greater than zero.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> +<span class="fu">invilr</span><span class="op">(</span><span class="va">x</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>A numeric vector. Naturally, the forward transformation is only +sensible for vectors with all elements being greater than zero.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The result of the forward or backward transformation. The returned components always sum to 1 for the case of the inverse log-ratio transformation.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>Peter Filzmoser, Karel Hron (2008) Outlier Detection for Compositional Data Using Robust Methods. Math Geosci 40 233-248</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Another implementation can be found in R package + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Another implementation can be found in R package <code>robCompositions</code>.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>René Lehmann and Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># Order matters</span> -<span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.1</span>, <span class='fl'>1</span>, <span class='fl'>10</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] -1.628174 -2.820079</div><div class='input'><span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>10</span>, <span class='fl'>1</span>, <span class='fl'>0.1</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 1.628174 2.820079</div><div class='input'><span class='co'># Equal entries give ilr transformations with zeros as elements</span> -<span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fl'>3</span>, <span class='fl'>3</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0 0</div><div class='input'><span class='co'># Almost equal entries give small numbers</span> -<span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.3</span>, <span class='fl'>0.4</span>, <span class='fl'>0.3</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] -0.2034219 0.1174457</div><div class='input'><span class='co'># Only the ratio between the numbers counts, not their sum</span> -<span class='fu'>invilr</span><span class='op'>(</span><span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.7</span>, <span class='fl'>0.29</span>, <span class='fl'>0.01</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.70 0.29 0.01</div><div class='input'><span class='fu'>invilr</span><span class='op'>(</span><span class='fu'>ilr</span><span class='op'>(</span><span class='fl'>2.1</span> <span class='op'>*</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.7</span>, <span class='fl'>0.29</span>, <span class='fl'>0.01</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.70 0.29 0.01</div><div class='input'><span class='co'># Inverse transformation of larger numbers gives unequal elements</span> -<span class='fu'>invilr</span><span class='op'>(</span><span class='op'>-</span><span class='fl'>10</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 7.213536e-07 9.999993e-01</div><div class='input'><span class='fu'>invilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='op'>-</span><span class='fl'>10</span>, <span class='fl'>0</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 7.207415e-07 9.991507e-01 8.486044e-04</div><div class='input'><span class='co'># The sum of the elements of the inverse ilr is 1</span> -<span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='fu'>invilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='op'>-</span><span class='fl'>10</span>, <span class='fl'>0</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 1</div><div class='input'><span class='co'># This is why we do not need all elements of the inverse transformation to go back:</span> -<span class='va'>a</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.1</span>, <span class='fl'>0.3</span>, <span class='fl'>0.5</span><span class='op'>)</span> -<span class='va'>b</span> <span class='op'><-</span> <span class='fu'>invilr</span><span class='op'>(</span><span class='va'>a</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>b</span><span class='op'>)</span> <span class='co'># Four elements</span> -</div><div class='output co'>#> [1] 4</div><div class='input'><span class='fu'>ilr</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='va'>b</span><span class='op'>[</span><span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>]</span>, <span class='fl'>1</span> <span class='op'>-</span> <span class='fu'><a href='https://rdrr.io/r/base/sum.html'>sum</a></span><span class='op'>(</span><span class='va'>b</span><span class='op'>[</span><span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>]</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> <span class='co'># Gives c(0.1, 0.3, 0.5)</span> -</div><div class='output co'>#> [1] 0.1 0.3 0.5</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># Order matters</span></span> +<span class="r-in"><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.1</span>, <span class="fl">1</span>, <span class="fl">10</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] -1.628174 -2.820079</span> +<span class="r-in"><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10</span>, <span class="fl">1</span>, <span class="fl">0.1</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1.628174 2.820079</span> +<span class="r-in"><span class="co"># Equal entries give ilr transformations with zeros as elements</span></span> +<span class="r-in"><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fl">3</span>, <span class="fl">3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0 0</span> +<span class="r-in"><span class="co"># Almost equal entries give small numbers</span></span> +<span class="r-in"><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.3</span>, <span class="fl">0.4</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] -0.2034219 0.1174457</span> +<span class="r-in"><span class="co"># Only the ratio between the numbers counts, not their sum</span></span> +<span class="r-in"><span class="fu">invilr</span><span class="op">(</span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.7</span>, <span class="fl">0.29</span>, <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.70 0.29 0.01</span> +<span class="r-in"><span class="fu">invilr</span><span class="op">(</span><span class="fu">ilr</span><span class="op">(</span><span class="fl">2.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.7</span>, <span class="fl">0.29</span>, <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.70 0.29 0.01</span> +<span class="r-in"><span class="co"># Inverse transformation of larger numbers gives unequal elements</span></span> +<span class="r-in"><span class="fu">invilr</span><span class="op">(</span><span class="op">-</span><span class="fl">10</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 7.213536e-07 9.999993e-01</span> +<span class="r-in"><span class="fu">invilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>, <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 7.207415e-07 9.991507e-01 8.486044e-04</span> +<span class="r-in"><span class="co"># The sum of the elements of the inverse ilr is 1</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="fu">invilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>, <span class="fl">0</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> +<span class="r-in"><span class="co"># This is why we do not need all elements of the inverse transformation to go back:</span></span> +<span class="r-in"><span class="va">a</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.1</span>, <span class="fl">0.3</span>, <span class="fl">0.5</span><span class="op">)</span></span> +<span class="r-in"><span class="va">b</span> <span class="op"><-</span> <span class="fu">invilr</span><span class="op">(</span><span class="va">a</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">b</span><span class="op">)</span> <span class="co"># Four elements</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 4</span> +<span class="r-in"><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="va">b</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, <span class="fl">1</span> <span class="op">-</span> <span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="va">b</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">)</span> <span class="co"># Gives c(0.1, 0.3, 0.5)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.1 0.3 0.5</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/index.html b/docs/reference/index.html index ff7a4198..552829bf 100644 --- a/docs/reference/index.html +++ b/docs/reference/index.html @@ -1,66 +1,12 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Function reference • mkin</title> - - -<!-- jquery --> 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href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -86,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -97,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -111,620 +58,402 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="contents col-md-9"> <div class="page-header"> <h1>Reference</h1> </div> - <table class="ref-index"> - - <colgroup> - - <col class="alias" /> - <col class="title" /> - </colgroup> - - <tbody> - <tr> - <th colspan="2"> - <h2 id="section-main-functions" class="hasAnchor"><a href="#section-main-functions" class="anchor"></a>Main functions</h2> - <p class="section-desc"><p>Essential functionality</p></p> + <table class="ref-index"><colgroup><col class="alias"><col class="title"></colgroup><tbody><tr><th colspan="2"> + <h2 id="main-functions">Main functions <a href="#main-functions" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Essential functionality</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="mkinmod.html">mkinmod()</a></code> <code><a href="mkinmod.html">print(<i><mkinmod></i>)</a></code> <code><a href="mkinmod.html">mkinsub()</a></code> </p> </td> <td><p>Function to set up a kinetic model with one or more state variables</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinfit.html">mkinfit()</a></code> </p> </td> <td><p>Fit a kinetic model to data with one or more state variables</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mmkin.html">mmkin()</a></code> <code><a href="mmkin.html">print(<i><mmkin></i>)</a></code> </p> </td> <td><p>Fit one or more kinetic models with one or more state variables to one or more datasets</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="nafta.html">nafta()</a></code> <code><a href="nafta.html">print(<i><nafta></i>)</a></code> </p> </td> <td><p>Evaluate parent kinetics using the NAFTA guidance</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-show-results" class="hasAnchor"><a href="#section-show-results" class="anchor"></a>Show results</h2> - <p class="section-desc"><p>Functions working with mkinfit objects</p></p> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="show-results">Show results <a href="#show-results" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Functions working with mkinfit objects</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="plot.mkinfit.html">plot(<i><mkinfit></i>)</a></code> <code><a href="plot.mkinfit.html">plot_sep()</a></code> <code><a href="plot.mkinfit.html">plot_res()</a></code> <code><a href="plot.mkinfit.html">plot_err()</a></code> </p> </td> <td><p>Plot the observed data and the fitted model of an mkinfit object</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="summary.mkinfit.html">summary(<i><mkinfit></i>)</a></code> <code><a href="summary.mkinfit.html">print(<i><summary.mkinfit></i>)</a></code> </p> </td> <td><p>Summary method for class "mkinfit"</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="parms.html">parms()</a></code> </p> </td> <td><p>Extract model parameters from mkinfit models</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="confint.mkinfit.html">confint(<i><mkinfit></i>)</a></code> </p> </td> <td><p>Confidence intervals for parameters of mkinfit objects</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="update.mkinfit.html">update(<i><mkinfit></i>)</a></code> </p> </td> <td><p>Update an mkinfit model with different arguments</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="lrtest.mkinfit.html">lrtest(<i><mkinfit></i>)</a></code> <code><a href="lrtest.mkinfit.html">lrtest(<i><mmkin></i>)</a></code> </p> </td> <td><p>Likelihood ratio test for mkinfit models</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="loftest.html">loftest()</a></code> </p> </td> <td><p>Lack-of-fit test for models fitted to data with replicates</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinerrmin.html">mkinerrmin()</a></code> </p> </td> <td><p>Calculate the minimum error to assume in order to pass the variance test</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="endpoints.html">endpoints()</a></code> </p> </td> <td><p>Function to calculate endpoints for further use from kinetic models fitted with mkinfit</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="aw.html">aw()</a></code> </p> </td> <td><p>Calculate Akaike weights for model averaging</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="CAKE_export.html">CAKE_export()</a></code> </p> </td> <td><p>Export a list of datasets format to a CAKE study file</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-work-with-mmkin-objects" class="hasAnchor"><a href="#section-work-with-mmkin-objects" class="anchor"></a>Work with mmkin objects</h2> - <p class="section-desc"><p>Functions working with aggregated results</p></p> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="work-with-mmkin-objects">Work with mmkin objects <a href="#work-with-mmkin-objects" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Functions working with aggregated results</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="Extract.mmkin.html">`[`(<i><mmkin></i>)</a></code> </p> </td> <td><p>Subsetting method for mmkin objects</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="plot.mmkin.html">plot(<i><mmkin></i>)</a></code> </p> </td> <td><p>Plot model fits (observed and fitted) and the residuals for a row or column of an mmkin object</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="AIC.mmkin.html">AIC(<i><mmkin></i>)</a></code> <code><a href="AIC.mmkin.html">BIC(<i><mmkin></i>)</a></code> </p> </td> <td><p>Calculate the AIC for a column of an mmkin object</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-mixed-models" class="hasAnchor"><a href="#section-mixed-models" class="anchor"></a>Mixed models</h2> - <p class="section-desc"><p>Create and work with nonlinear mixed effects models</p></p> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="mixed-models">Mixed models <a href="#mixed-models" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Create and work with nonlinear mixed effects models</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="nlme.mmkin.html">nlme(<i><mmkin></i>)</a></code> <code><a href="nlme.mmkin.html">print(<i><nlme.mmkin></i>)</a></code> <code><a href="nlme.mmkin.html">update(<i><nlme.mmkin></i>)</a></code> </p> </td> <td><p>Create an nlme model for an mmkin row object</p></td> - </tr><tr> - - <td> + </tr><tr><td> + <p><code><a href="saem.html">saem()</a></code> <code><a href="saem.html">print(<i><saem.mmkin></i>)</a></code> <code><a href="saem.html">saemix_model()</a></code> <code><a href="saem.html">saemix_data()</a></code> </p> + </td> + <td><p>Fit nonlinear mixed models with SAEM</p></td> + </tr><tr><td> + <p><code><a href="nlmixr.mmkin.html">nlmixr(<i><mmkin></i>)</a></code> <code><a href="nlmixr.mmkin.html">print(<i><nlmixr.mmkin></i>)</a></code> <code><a href="nlmixr.mmkin.html">nlmixr_model()</a></code> <code><a href="nlmixr.mmkin.html">nlmixr_data()</a></code> </p> + </td> + <td><p>Fit nonlinear mixed models using nlmixr</p></td> + </tr><tr><td> <p><code><a href="plot.mixed.mmkin.html">plot(<i><mixed.mmkin></i>)</a></code> </p> </td> <td><p>Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="summary.nlme.mmkin.html">summary(<i><nlme.mmkin></i>)</a></code> <code><a href="summary.nlme.mmkin.html">print(<i><summary.nlme.mmkin></i>)</a></code> </p> </td> <td><p>Summary method for class "nlme.mmkin"</p></td> - </tr><tr> - - <td> - <p><code><a href="nlme.html">nlme_function()</a></code> <code><a href="nlme.html">mean_degparms()</a></code> <code><a href="nlme.html">nlme_data()</a></code> </p> + </tr><tr><td> + <p><code><a href="summary.nlmixr.mmkin.html">summary(<i><nlmixr.mmkin></i>)</a></code> <code><a href="summary.nlmixr.mmkin.html">print(<i><summary.nlmixr.mmkin></i>)</a></code> </p> + </td> + <td><p>Summary method for class "nlmixr.mmkin"</p></td> + </tr><tr><td> + <p><code><a href="summary.saem.mmkin.html">summary(<i><saem.mmkin></i>)</a></code> <code><a href="summary.saem.mmkin.html">print(<i><summary.saem.mmkin></i>)</a></code> </p> + </td> + <td><p>Summary method for class "saem.mmkin"</p></td> + </tr><tr><td> + <p><code><a href="nlme.html">nlme_function()</a></code> <code><a href="nlme.html">nlme_data()</a></code> </p> </td> <td><p>Helper functions to create nlme models from mmkin row objects</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="get_deg_func.html">get_deg_func()</a></code> </p> </td> <td><p>Retrieve a degradation function from the mmkin namespace</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mixed.html">mixed()</a></code> <code><a href="mixed.html">print(<i><mixed.mmkin></i>)</a></code> </p> </td> <td><p>Create a mixed effects model from an mmkin row object</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-datasets-and-known-results" class="hasAnchor"><a href="#section-datasets-and-known-results" class="anchor"></a>Datasets and known results</h2> + </tr><tr><td> + <p><code><a href="reexports.html">reexports</a></code> </p> + </td> + <td><p>Objects exported from other packages</p></td> + </tr><tr><td> + <p><code><a href="intervals.saem.mmkin.html">intervals(<i><saem.mmkin></i>)</a></code> </p> + </td> + <td><p>Confidence intervals for parameters in saem.mmkin objects</p></td> + </tr><tr><td> + <p><code><a href="intervals.nlmixr.mmkin.html">intervals(<i><nlmixr.mmkin></i>)</a></code> </p> + </td> + <td><p>Confidence intervals for parameters in nlmixr.mmkin objects</p></td> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="datasets-and-known-results">Datasets and known results <a href="#datasets-and-known-results" class="anchor" aria-hidden="true"></a></h2> <p class="section-desc"></p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="focus_soil_moisture.html">focus_soil_moisture</a></code> </p> </td> <td><p>FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="D24_2014.html">D24_2014</a></code> </p> </td> <td><p>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="dimethenamid_2018.html">dimethenamid_2018</a></code> </p> </td> <td><p>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOCUS_2006_datasets.html">FOCUS_2006_A</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_B</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_C</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_D</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_E</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_F</a></code> </p> </td> <td><p>Datasets A to F from the FOCUS Kinetics report from 2006</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOCUS_2006_SFO_ref_A_to_F.html">FOCUS_2006_SFO_ref_A_to_F</a></code> </p> </td> <td><p>Results of fitting the SFO model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOCUS_2006_FOMC_ref_A_to_F.html">FOCUS_2006_FOMC_ref_A_to_F</a></code> </p> </td> <td><p>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOCUS_2006_HS_ref_A_to_F.html">FOCUS_2006_HS_ref_A_to_F</a></code> </p> </td> <td><p>Results of fitting the HS model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOCUS_2006_DFOP_ref_A_to_B.html">FOCUS_2006_DFOP_ref_A_to_B</a></code> </p> </td> <td><p>Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="NAFTA_SOP_2015.html">NAFTA_SOP_Appendix_B</a></code> <code><a href="NAFTA_SOP_2015.html">NAFTA_SOP_Appendix_D</a></code> </p> </td> <td><p>Example datasets from the NAFTA SOP published 2015</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="NAFTA_SOP_Attachment.html">NAFTA_SOP_Attachment</a></code> </p> </td> <td><p>Example datasets from Attachment 1 to the NAFTA SOP published 2015</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mccall81_245T.html">mccall81_245T</a></code> </p> </td> <td><p>Datasets on aerobic soil metabolism of 2,4,5-T in six soils</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="schaefer07_complex_case.html">schaefer07_complex_case</a></code> </p> </td> <td><p>Metabolism data set used for checking the software quality of KinGUI</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="synthetic_data_for_UBA_2014.html">synthetic_data_for_UBA_2014</a></code> </p> </td> <td><p>Synthetic datasets for one parent compound with two metabolites</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="experimental_data_for_UBA.html">experimental_data_for_UBA_2019</a></code> </p> </td> <td><p>Experimental datasets used for development and testing of error models</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="test_data_from_UBA_2014.html">test_data_from_UBA_2014</a></code> </p> </td> <td><p>Three experimental datasets from two water sediment systems and one soil</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinds.html">print(<i><mkinds></i>)</a></code> </p> </td> <td><p>A dataset class for mkin</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkindsg.html">print(<i><mkindsg></i>)</a></code> </p> </td> <td><p>A class for dataset groups for mkin</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-nafta-guidance" class="hasAnchor"><a href="#section-nafta-guidance" class="anchor"></a>NAFTA guidance</h2> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="nafta-guidance">NAFTA guidance <a href="#nafta-guidance" class="anchor" aria-hidden="true"></a></h2> <p class="section-desc"></p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="nafta.html">nafta()</a></code> <code><a href="nafta.html">print(<i><nafta></i>)</a></code> </p> </td> <td><p>Evaluate parent kinetics using the NAFTA guidance</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="plot.nafta.html">plot(<i><nafta></i>)</a></code> </p> </td> <td><p>Plot the results of the three models used in the NAFTA scheme.</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-utility-functions" class="hasAnchor"><a href="#section-utility-functions" class="anchor"></a>Utility functions</h2> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="utility-functions">Utility functions <a href="#utility-functions" class="anchor" aria-hidden="true"></a></h2> <p class="section-desc"></p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="f_time_norm_focus.html">f_time_norm_focus()</a></code> </p> </td> <td><p>Normalisation factors for aerobic soil degradation according to FOCUS guidance</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="max_twa_parent.html">max_twa_parent()</a></code> <code><a href="max_twa_parent.html">max_twa_sfo()</a></code> <code><a href="max_twa_parent.html">max_twa_fomc()</a></code> <code><a href="max_twa_parent.html">max_twa_dfop()</a></code> <code><a href="max_twa_parent.html">max_twa_hs()</a></code> </p> </td> <td><p>Function to calculate maximum time weighted average concentrations from kinetic models fitted with mkinfit</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkin_wide_to_long.html">mkin_wide_to_long()</a></code> </p> </td> <td><p>Convert a dataframe with observations over time into long format</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkin_long_to_wide.html">mkin_long_to_wide()</a></code> </p> </td> <td><p>Convert a dataframe from long to wide format</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-helper-functions-mainly-used-internally" class="hasAnchor"><a href="#section-helper-functions-mainly-used-internally" class="anchor"></a>Helper functions mainly used internally</h2> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="helper-functions-mainly-used-internally">Helper functions mainly used internally <a href="#helper-functions-mainly-used-internally" class="anchor" aria-hidden="true"></a></h2> <p class="section-desc"></p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="mkinpredict.html">mkinpredict()</a></code> </p> </td> <td><p>Produce predictions from a kinetic model using specific parameters</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="transform_odeparms.html">transform_odeparms()</a></code> <code><a href="transform_odeparms.html">backtransform_odeparms()</a></code> </p> </td> <td><p>Functions to transform and backtransform kinetic parameters for fitting</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="ilr.html">ilr()</a></code> <code><a href="ilr.html">invilr()</a></code> </p> </td> <td><p>Function to perform isometric log-ratio transformation</p></td> - </tr><tr> - - <td> + </tr><tr><td> + <p><code><a href="tffm0.html">tffm0()</a></code> <code><a href="tffm0.html">invtffm0()</a></code> </p> + </td> + <td><p>Transform formation fractions as in the first published mkin version</p></td> + </tr><tr><td> <p><code><a href="logLik.mkinfit.html">logLik(<i><mkinfit></i>)</a></code> </p> </td> <td><p>Calculated the log-likelihood of a fitted mkinfit object</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="residuals.mkinfit.html">residuals(<i><mkinfit></i>)</a></code> </p> </td> <td><p>Extract residuals from an mkinfit model</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="nobs.mkinfit.html">nobs(<i><mkinfit></i>)</a></code> </p> </td> <td><p>Number of observations on which an mkinfit object was fitted</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinresplot.html">mkinresplot()</a></code> </p> </td> <td><p>Function to plot residuals stored in an mkin object</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinparplot.html">mkinparplot()</a></code> </p> </td> <td><p>Function to plot the confidence intervals obtained using mkinfit</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="mkinerrplot.html">mkinerrplot()</a></code> </p> </td> <td><p>Function to plot squared residuals and the error model for an mkin object</p></td> - </tr><tr> - - <td> + </tr><tr><td> + <p><code><a href="mean_degparms.html">mean_degparms()</a></code> </p> + </td> + <td><p>Calculate mean degradation parameters for an mmkin row object</p></td> + </tr><tr><td> <p><code><a href="create_deg_func.html">create_deg_func()</a></code> </p> </td> <td><p>Create degradation functions for known analytical solutions</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-analytical-solutions" class="hasAnchor"><a href="#section-analytical-solutions" class="anchor"></a>Analytical solutions</h2> - <p class="section-desc"><p>Parent only model solutions</p></p> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="analytical-solutions">Analytical solutions <a href="#analytical-solutions" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Parent only model solutions</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="SFO.solution.html">SFO.solution()</a></code> </p> </td> <td><p>Single First-Order kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="FOMC.solution.html">FOMC.solution()</a></code> </p> </td> <td><p>First-Order Multi-Compartment kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="DFOP.solution.html">DFOP.solution()</a></code> </p> </td> <td><p>Double First-Order in Parallel kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="SFORB.solution.html">SFORB.solution()</a></code> </p> </td> <td><p>Single First-Order Reversible Binding kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="HS.solution.html">HS.solution()</a></code> </p> </td> <td><p>Hockey-Stick kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="IORE.solution.html">IORE.solution()</a></code> </p> </td> <td><p>Indeterminate order rate equation kinetics</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="logistic.solution.html">logistic.solution()</a></code> </p> </td> <td><p>Logistic kinetics</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-generate-synthetic-datasets" class="hasAnchor"><a href="#section-generate-synthetic-datasets" class="anchor"></a>Generate synthetic datasets</h2> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="generate-synthetic-datasets">Generate synthetic datasets <a href="#generate-synthetic-datasets" class="anchor" aria-hidden="true"></a></h2> <p class="section-desc"></p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="add_err.html">add_err()</a></code> </p> </td> <td><p>Add normally distributed errors to simulated kinetic degradation data</p></td> - </tr><tr> - - <td> + </tr><tr><td> <p><code><a href="sigma_twocomp.html">sigma_twocomp()</a></code> </p> </td> <td><p>Two-component error model</p></td> - </tr> - </tbody><tbody> - <tr> - <th colspan="2"> - <h2 id="section-deprecated-functions" class="hasAnchor"><a href="#section-deprecated-functions" class="anchor"></a>Deprecated functions</h2> - <p class="section-desc"><p>Functions that have been superseded</p></p> + </tr></tbody><tbody><tr><th colspan="2"> + <h2 id="deprecated-functions">Deprecated functions <a href="#deprecated-functions" class="anchor" aria-hidden="true"></a></h2> + <p class="section-desc"></p><p>Functions that have been superseded</p> </th> - </tr> - - - </tbody><tbody> - - - <tr> - - <td> + </tr></tbody><tbody><tr><td> <p><code><a href="mkinplot.html">mkinplot()</a></code> </p> </td> <td><p>Plot the observed data and the fitted model of an mkinfit object</p></td> - </tr> - </tbody> - </table> - </div> + </tr></tbody></table></div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by 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class="op">(</span><span class="va">object</span>, level <span class="op">=</span> <span class="fl">0.95</span>, backtransform <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>The fitted saem.mmkin object</p></dd> +<dt>level</dt> +<dd><p>The confidence level.</p></dd> +<dt>backtransform</dt> +<dd><p>Should we backtransform the parameters where a one to +one correlation between transformed and backtransformed parameters exists?</p></dd> +<dt>...</dt> +<dd><p>For compatibility with the generic method</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An object with 'intervals.saem.mmkin' and 'intervals.lme' in the +class attribute</p> + </div> + + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + 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href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Confidence intervals for parameters in saem.mmkin objects</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/intervals.R" class="external-link"><code>R/intervals.R</code></a></small> + <div class="hidden name"><code>intervals.saem.mmkin.Rd</code></div> + </div> + + <div class="ref-description"> + <p>Confidence intervals for parameters in saem.mmkin objects</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for saem.mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></span><span class="op">(</span><span class="va">object</span>, level <span class="op">=</span> <span class="fl">0.95</span>, backtransform <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>The fitted saem.mmkin object</p></dd> +<dt>level</dt> +<dd><p>The confidence level. Must be the default of 0.95 as this is what +is available in the saemix object</p></dd> +<dt>backtransform</dt> +<dd><p>In case the model was fitted with mkin transformations, +should we backtransform the parameters where a one to one correlation +between transformed and backtransformed parameters exists?</p></dd> +<dt>...</dt> +<dd><p>For compatibility with the generic method</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An object with 'intervals.saem.mmkin' and 'intervals.lme' in the +class attribute</p> + </div> + + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/loftest-1.png b/docs/reference/loftest-1.png Binary files differindex d6006ecc..f1dc5fa7 100644 --- a/docs/reference/loftest-1.png +++ b/docs/reference/loftest-1.png diff --git a/docs/reference/loftest-2.png b/docs/reference/loftest-2.png Binary files differindex 4d0dc551..3f1015a9 100644 --- a/docs/reference/loftest-2.png +++ b/docs/reference/loftest-2.png diff --git a/docs/reference/loftest-3.png b/docs/reference/loftest-3.png Binary files differindex 6afd084b..d897c363 100644 --- a/docs/reference/loftest-3.png +++ b/docs/reference/loftest-3.png diff --git a/docs/reference/loftest-4.png b/docs/reference/loftest-4.png Binary files differindex f94eede1..ac44c162 100644 --- a/docs/reference/loftest-4.png +++ b/docs/reference/loftest-4.png diff --git a/docs/reference/loftest-5.png b/docs/reference/loftest-5.png Binary files differindex 43460a65..0847bbec 100644 --- a/docs/reference/loftest-5.png +++ b/docs/reference/loftest-5.png diff --git a/docs/reference/loftest.html b/docs/reference/loftest.html index 6e72774e..75578cbe 100644 --- a/docs/reference/loftest.html +++ b/docs/reference/loftest.html @@ -1,70 +1,15 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Lack-of-fit test for models fitted to data with replicates — loftest • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - -<!-- Font Awesome icons --> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous" /> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" /> - -<!-- clipboard.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script> - -<!-- headroom.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script> - -<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Lack-of-fit test for models fitted to data with replicates — loftest" /> -<meta property="og:description" content="This is a generic function with a method currently only defined for mkinfit +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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It fits an anova model to the data contained in the object and compares the likelihoods using the likelihood ratio test -lrtest.default from the lmtest package." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +lrtest.default from the lmtest package."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ lrtest.default from the lmtest package." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ lrtest.default from the lmtest package." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ lrtest.default from the lmtest package." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,34 +61,27 @@ lrtest.default from the lmtest package." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Lack-of-fit test for models fitted to data with replicates</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/loftest.R'><code>R/loftest.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/loftest.R" class="external-link"><code>R/loftest.R</code></a></small> <div class="hidden name"><code>loftest.Rd</code></div> </div> @@ -150,216 +89,228 @@ lrtest.default from the lmtest package." /> <p>This is a generic function with a method currently only defined for mkinfit objects. It fits an anova model to the data contained in the object and compares the likelihoods using the likelihood ratio test -<code><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest.default</a></code> from the lmtest package.</p> +<code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest.default</a></code> from the lmtest package.</p> </div> - <pre class="usage"><span class='fu'>loftest</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">loftest</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> -<span class='co'># S3 method for mkinfit</span> -<span class='fu'>loftest</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A model object with a defined loftest method</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> +<span class="co"># S3 method for mkinfit</span> +<span class="fu">loftest</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A model object with a defined loftest method</p></dd> +<dt>...</dt> +<dd><p>Not used</p></dd> +</dl></div> + <div id="details"> + <h2>Details</h2> <p>The anova model is interpreted as the simplest form of an mkinfit model, assuming only a constant variance about the means, but not enforcing any structure of the means, so we have one model parameter for every mean of replicate samples.</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>lrtest</p></div> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>lrtest</p></div> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> -<span class='va'>test_data</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>12</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, <span class='va'>name</span> <span class='op'>==</span> <span class='st'>"parent"</span><span class='op'>)</span> -<span class='va'>sfo_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>test_data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>sfo_fit</span><span class='op'>)</span> <span class='co'># We see a clear pattern in the residuals</span> -</div><div class='img'><img src='loftest-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>loftest</span><span class='op'>(</span><span class='va'>sfo_fit</span><span class='op'>)</span> <span class='co'># We have a clear lack of fit</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: ANOVA with error model const -#> Model 2: SFO with error model const -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 10 -40.710 -#> 2 3 -63.954 -7 46.487 7.027e-08 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='co'>#</span> -<span class='co'># We try a different model (the one that was used to generate the data)</span> -<span class='va'>dfop_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>test_data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>dfop_fit</span><span class='op'>)</span> <span class='co'># We don't see systematic deviations, but heteroscedastic residuals</span> -</div><div class='img'><img src='loftest-2.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># therefore we should consider adapting the error model, although we have</span> -<span class='fu'>loftest</span><span class='op'>(</span><span class='va'>dfop_fit</span><span class='op'>)</span> <span class='co'># no lack of fit</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: ANOVA with error model const -#> Model 2: DFOP with error model const -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 10 -40.710 -#> 2 5 -42.453 -5 3.485 0.6257</div><div class='input'><span class='co'>#</span> -<span class='co'># This is the anova model used internally for the comparison</span> -<span class='va'>test_data_anova</span> <span class='op'><-</span> <span class='va'>test_data</span> -<span class='va'>test_data_anova</span><span class='op'>$</span><span class='va'>time</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/factor.html'>as.factor</a></span><span class='op'>(</span><span class='va'>test_data_anova</span><span class='op'>$</span><span class='va'>time</span><span class='op'>)</span> -<span class='va'>anova_fit</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/lm.html'>lm</a></span><span class='op'>(</span><span class='va'>value</span> <span class='op'>~</span> <span class='va'>time</span>, data <span class='op'>=</span> <span class='va'>test_data_anova</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>anova_fit</span><span class='op'>)</span> -</div><div class='output co'>#> -#> Call: -#> lm(formula = value ~ time, data = test_data_anova) -#> -#> Residuals: -#> Min 1Q Median 3Q Max -#> -6.1000 -0.5625 0.0000 0.5625 6.1000 -#> -#> Coefficients: -#> Estimate Std. Error t value Pr(>|t|) -#> (Intercept) 103.150 2.323 44.409 7.44e-12 *** -#> time1 -19.950 3.285 -6.073 0.000185 *** -#> time3 -50.800 3.285 -15.465 8.65e-08 *** -#> time7 -68.500 3.285 -20.854 6.28e-09 *** -#> time14 -79.750 3.285 -24.278 1.63e-09 *** -#> time28 -86.000 3.285 -26.181 8.35e-10 *** -#> time60 -94.900 3.285 -28.891 3.48e-10 *** -#> time90 -98.500 3.285 -29.986 2.49e-10 *** -#> time120 -100.450 3.285 -30.580 2.09e-10 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 -#> -#> Residual standard error: 3.285 on 9 degrees of freedom -#> Multiple R-squared: 0.9953, Adjusted R-squared: 0.9912 -#> F-statistic: 240.5 on 8 and 9 DF, p-value: 1.417e-09 -#> </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/stats/logLik.html'>logLik</a></span><span class='op'>(</span><span class='va'>anova_fit</span><span class='op'>)</span> <span class='co'># We get the same likelihood and degrees of freedom</span> -</div><div class='output co'>#> 'log Lik.' -40.71015 (df=10)</div><div class='input'><span class='co'>#</span> -<span class='va'>test_data_2</span> <span class='op'><-</span> <span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>12</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span> -<span class='va'>m_synth_SFO_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"M2"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>sfo_lin_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_SFO_lin</span>, <span class='va'>test_data_2</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>sfo_lin_fit</span><span class='op'>)</span> <span class='co'># not a good model, we try parallel formation</span> -</div><div class='img'><img src='loftest-3.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>loftest</span><span class='op'>(</span><span class='va'>sfo_lin_fit</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: ANOVA with error model const -#> Model 2: m_synth_SFO_lin with error model const and fixed parameter(s) M1_0, M2_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 28 -93.606 -#> 2 7 -171.927 -21 156.64 < 2.2e-16 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='co'>#</span> -<span class='va'>m_synth_SFO_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>sfo_par_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_SFO_par</span>, <span class='va'>test_data_2</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>sfo_par_fit</span><span class='op'>)</span> <span class='co'># much better for metabolites</span> -</div><div class='img'><img src='loftest-4.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>loftest</span><span class='op'>(</span><span class='va'>sfo_par_fit</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: ANOVA with error model const -#> Model 2: m_synth_SFO_par with error model const and fixed parameter(s) M1_0, M2_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 28 -93.606 -#> 2 7 -156.331 -21 125.45 < 2.2e-16 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='co'>#</span> -<span class='va'>m_synth_DFOP_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>dfop_par_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_DFOP_par</span>, <span class='va'>test_data_2</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>dfop_par_fit</span><span class='op'>)</span> <span class='co'># No visual lack of fit</span> -</div><div class='img'><img src='loftest-5.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>loftest</span><span class='op'>(</span><span class='va'>dfop_par_fit</span><span class='op'>)</span> <span class='co'># no lack of fit found by the test</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: ANOVA with error model const -#> Model 2: m_synth_DFOP_par with error model const and fixed parameter(s) M1_0, M2_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 28 -93.606 -#> 2 9 -102.763 -19 18.313 0.5016</div><div class='input'><span class='co'>#</span> -<span class='co'># The anova model used for comparison in the case of transformation products</span> -<span class='va'>test_data_anova_2</span> <span class='op'><-</span> <span class='va'>dfop_par_fit</span><span class='op'>$</span><span class='va'>data</span> -<span class='va'>test_data_anova_2</span><span class='op'>$</span><span class='va'>variable</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/factor.html'>as.factor</a></span><span class='op'>(</span><span class='va'>test_data_anova_2</span><span class='op'>$</span><span class='va'>variable</span><span class='op'>)</span> -<span class='va'>test_data_anova_2</span><span class='op'>$</span><span class='va'>time</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/factor.html'>as.factor</a></span><span class='op'>(</span><span class='va'>test_data_anova_2</span><span class='op'>$</span><span class='va'>time</span><span class='op'>)</span> -<span class='va'>anova_fit_2</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/lm.html'>lm</a></span><span class='op'>(</span><span class='va'>observed</span> <span class='op'>~</span> <span class='va'>time</span><span class='op'>:</span><span class='va'>variable</span> <span class='op'>-</span> <span class='fl'>1</span>, data <span class='op'>=</span> <span class='va'>test_data_anova_2</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>anova_fit_2</span><span class='op'>)</span> -</div><div class='output co'>#> -#> Call: -#> lm(formula = observed ~ time:variable - 1, data = test_data_anova_2) -#> -#> Residuals: -#> Min 1Q Median 3Q Max -#> -6.1000 -0.5875 0.0000 0.5875 6.1000 -#> -#> Coefficients: (2 not defined because of singularities) -#> Estimate Std. Error t value Pr(>|t|) -#> time0:variableparent 103.150 1.573 65.562 < 2e-16 *** -#> time1:variableparent 83.200 1.573 52.882 < 2e-16 *** -#> time3:variableparent 52.350 1.573 33.274 < 2e-16 *** -#> time7:variableparent 34.650 1.573 22.024 < 2e-16 *** -#> time14:variableparent 23.400 1.573 14.873 6.35e-14 *** -#> time28:variableparent 17.150 1.573 10.901 5.47e-11 *** -#> time60:variableparent 8.250 1.573 5.244 1.99e-05 *** -#> time90:variableparent 4.650 1.573 2.956 0.006717 ** -#> time120:variableparent 2.700 1.573 1.716 0.098507 . -#> time0:variableM1 NA NA NA NA -#> time1:variableM1 11.850 1.573 7.532 6.93e-08 *** -#> time3:variableM1 22.700 1.573 14.428 1.26e-13 *** -#> time7:variableM1 33.050 1.573 21.007 < 2e-16 *** -#> time14:variableM1 31.250 1.573 19.863 < 2e-16 *** -#> time28:variableM1 18.900 1.573 12.013 7.02e-12 *** -#> time60:variableM1 7.550 1.573 4.799 6.28e-05 *** -#> time90:variableM1 3.850 1.573 2.447 0.021772 * -#> time120:variableM1 2.050 1.573 1.303 0.204454 -#> time0:variableM2 NA NA NA NA -#> time1:variableM2 6.700 1.573 4.259 0.000254 *** -#> time3:variableM2 16.750 1.573 10.646 8.93e-11 *** -#> time7:variableM2 25.800 1.573 16.399 6.89e-15 *** -#> time14:variableM2 28.600 1.573 18.178 6.35e-16 *** -#> time28:variableM2 25.400 1.573 16.144 9.85e-15 *** -#> time60:variableM2 21.600 1.573 13.729 3.81e-13 *** -#> time90:variableM2 17.800 1.573 11.314 2.51e-11 *** -#> time120:variableM2 14.100 1.573 8.962 2.79e-09 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 -#> -#> Residual standard error: 2.225 on 25 degrees of freedom -#> Multiple R-squared: 0.9979, Adjusted R-squared: 0.9957 -#> F-statistic: 469.2 on 25 and 25 DF, p-value: < 2.2e-16 -#> </div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">test_data</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">sfo_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_fit</span><span class="op">)</span> <span class="co"># We see a clear pattern in the residuals</span></span> +<span class="r-plt img"><img src="loftest-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_fit</span><span class="op">)</span> <span class="co"># We have a clear lack of fit</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 10 -40.710 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -7 46.487 7.027e-08 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="co"># We try a different model (the one that was used to generate the data)</span></span> +<span class="r-in"><span class="va">dfop_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">dfop_fit</span><span class="op">)</span> <span class="co"># We don't see systematic deviations, but heteroscedastic residuals</span></span> +<span class="r-plt img"><img src="loftest-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># therefore we should consider adapting the error model, although we have</span></span> +<span class="r-in"><span class="fu">loftest</span><span class="op">(</span><span class="va">dfop_fit</span><span class="op">)</span> <span class="co"># no lack of fit</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> +<span class="r-out co"><span class="r-pr">#></span> 1 10 -40.710 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 5 -42.453 -5 3.485 0.6257</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="co"># This is the anova model used internally for the comparison</span></span> +<span class="r-in"><span class="va">test_data_anova</span> <span class="op"><-</span> <span class="va">test_data</span></span> +<span class="r-in"><span class="va">test_data_anova</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova</span><span class="op">$</span><span class="va">time</span><span class="op">)</span></span> +<span class="r-in"><span class="va">anova_fit</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/lm.html" class="external-link">lm</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="va">time</span>, data <span class="op">=</span> <span class="va">test_data_anova</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">anova_fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Call:</span> +<span class="r-out co"><span class="r-pr">#></span> lm(formula = value ~ time, data = test_data_anova)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Residuals:</span> +<span class="r-out co"><span class="r-pr">#></span> Min 1Q Median 3Q Max </span> +<span class="r-out co"><span class="r-pr">#></span> -6.1000 -0.5625 0.0000 0.5625 6.1000 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Coefficients:</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error t value Pr(>|t|) </span> +<span class="r-out co"><span class="r-pr">#></span> (Intercept) 103.150 2.323 44.409 7.44e-12 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time1 -19.950 3.285 -6.073 0.000185 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time3 -50.800 3.285 -15.465 8.65e-08 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time7 -68.500 3.285 -20.854 6.28e-09 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time14 -79.750 3.285 -24.278 1.63e-09 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time28 -86.000 3.285 -26.181 8.35e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time60 -94.900 3.285 -28.891 3.48e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time90 -98.500 3.285 -29.986 2.49e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time120 -100.450 3.285 -30.580 2.09e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Residual standard error: 3.285 on 9 degrees of freedom</span> +<span class="r-out co"><span class="r-pr">#></span> Multiple R-squared: 0.9953, Adjusted R-squared: 0.9912 </span> +<span class="r-out co"><span class="r-pr">#></span> F-statistic: 240.5 on 8 and 9 DF, p-value: 1.417e-09</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></span><span class="op">(</span><span class="va">anova_fit</span><span class="op">)</span> <span class="co"># We get the same likelihood and degrees of freedom</span></span> +<span class="r-out co"><span class="r-pr">#></span> 'log Lik.' -40.71015 (df=10)</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="va">test_data_2</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> +<span class="r-in"><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">sfo_lin_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_lin_fit</span><span class="op">)</span> <span class="co"># not a good model, we try parallel formation</span></span> +<span class="r-plt img"><img src="loftest-3.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_lin_fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_SFO_lin with error model const and fixed parameter(s) M1_0, M2_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 7 -171.927 -21 156.64 < 2.2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="va">m_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">sfo_par_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_par</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_par_fit</span><span class="op">)</span> <span class="co"># much better for metabolites</span></span> +<span class="r-plt img"><img src="loftest-4.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_par_fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_SFO_par with error model const and fixed parameter(s) M1_0, M2_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 7 -156.331 -21 125.45 < 2.2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">dfop_par_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">dfop_par_fit</span><span class="op">)</span> <span class="co"># No visual lack of fit</span></span> +<span class="r-plt img"><img src="loftest-5.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">loftest</span><span class="op">(</span><span class="va">dfop_par_fit</span><span class="op">)</span> <span class="co"># no lack of fit found by the test</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_DFOP_par with error model const and fixed parameter(s) M1_0, M2_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> +<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 9 -102.763 -19 18.313 0.5016</span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="co"># The anova model used for comparison in the case of transformation products</span></span> +<span class="r-in"><span class="va">test_data_anova_2</span> <span class="op"><-</span> <span class="va">dfop_par_fit</span><span class="op">$</span><span class="va">data</span></span> +<span class="r-in"><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">variable</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">variable</span><span class="op">)</span></span> +<span class="r-in"><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">time</span><span class="op">)</span></span> +<span class="r-in"><span class="va">anova_fit_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/lm.html" class="external-link">lm</a></span><span class="op">(</span><span class="va">observed</span> <span class="op">~</span> <span class="va">time</span><span class="op">:</span><span class="va">variable</span> <span class="op">-</span> <span class="fl">1</span>, data <span class="op">=</span> <span class="va">test_data_anova_2</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">anova_fit_2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Call:</span> +<span class="r-out co"><span class="r-pr">#></span> lm(formula = observed ~ time:variable - 1, data = test_data_anova_2)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Residuals:</span> +<span class="r-out co"><span class="r-pr">#></span> Min 1Q Median 3Q Max </span> +<span class="r-out co"><span class="r-pr">#></span> -6.1000 -0.5875 0.0000 0.5875 6.1000 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Coefficients: (2 not defined because of singularities)</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error t value Pr(>|t|) </span> +<span class="r-out co"><span class="r-pr">#></span> time0:variableparent 103.150 1.573 65.562 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time1:variableparent 83.200 1.573 52.882 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time3:variableparent 52.350 1.573 33.274 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time7:variableparent 34.650 1.573 22.024 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time14:variableparent 23.400 1.573 14.873 6.35e-14 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time28:variableparent 17.150 1.573 10.901 5.47e-11 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time60:variableparent 8.250 1.573 5.244 1.99e-05 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time90:variableparent 4.650 1.573 2.956 0.006717 ** </span> +<span class="r-out co"><span class="r-pr">#></span> time120:variableparent 2.700 1.573 1.716 0.098507 . </span> +<span class="r-out co"><span class="r-pr">#></span> time0:variableM1 NA NA NA NA </span> +<span class="r-out co"><span class="r-pr">#></span> time1:variableM1 11.850 1.573 7.532 6.93e-08 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time3:variableM1 22.700 1.573 14.428 1.26e-13 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time7:variableM1 33.050 1.573 21.007 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time14:variableM1 31.250 1.573 19.863 < 2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time28:variableM1 18.900 1.573 12.013 7.02e-12 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time60:variableM1 7.550 1.573 4.799 6.28e-05 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time90:variableM1 3.850 1.573 2.447 0.021772 * </span> +<span class="r-out co"><span class="r-pr">#></span> time120:variableM1 2.050 1.573 1.303 0.204454 </span> +<span class="r-out co"><span class="r-pr">#></span> time0:variableM2 NA NA NA NA </span> +<span class="r-out co"><span class="r-pr">#></span> time1:variableM2 6.700 1.573 4.259 0.000254 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time3:variableM2 16.750 1.573 10.646 8.93e-11 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time7:variableM2 25.800 1.573 16.399 6.89e-15 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time14:variableM2 28.600 1.573 18.178 6.35e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time28:variableM2 25.400 1.573 16.144 9.85e-15 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time60:variableM2 21.600 1.573 13.729 3.81e-13 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time90:variableM2 17.800 1.573 11.314 2.51e-11 ***</span> +<span class="r-out co"><span class="r-pr">#></span> time120:variableM2 14.100 1.573 8.962 2.79e-09 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Residual standard error: 2.225 on 25 degrees of freedom</span> +<span class="r-out co"><span class="r-pr">#></span> Multiple R-squared: 0.9979, Adjusted R-squared: 0.9957 </span> +<span class="r-out co"><span class="r-pr">#></span> F-statistic: 469.2 on 25 and 25 DF, p-value: < 2.2e-16</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 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<li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ the error model." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ the error model." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,122 +62,115 @@ the error model." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Calculated the log-likelihood of a fitted mkinfit object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/logLik.mkinfit.R'><code>R/logLik.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/logLik.mkinfit.R" class="external-link"><code>R/logLik.mkinfit.R</code></a></small> <div class="hidden name"><code>logLik.mkinfit.Rd</code></div> </div> <div class="ref-description"> <p>This function returns the product of the likelihood densities of each observed value, as calculated as part of the fitting procedure using -<code><a href='https://rdrr.io/r/stats/Normal.html'>dnorm</a></code>, i.e. assuming normal distribution, and with the means +<code><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">dnorm</a></code>, i.e. assuming normal distribution, and with the means predicted by the degradation model, and the standard deviations predicted by the error model.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/stats/logLik.html'>logLik</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>For compatibility with the generic method</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>An object of class <code><a href='https://rdrr.io/r/stats/logLik.html'>logLik</a></code> with the number of estimated + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>...</dt> +<dd><p>For compatibility with the generic method</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An object of class <code><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></code> with the number of estimated parameters (degradation model parameters plus variance model parameters) as attribute.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>The total number of estimated parameters returned with the value of the likelihood is calculated as the sum of fitted degradation model parameters and the fitted error model parameters.</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Compare the AIC of columns of <code><a href='mmkin.html'>mmkin</a></code> objects using -<code><a href='AIC.mmkin.html'>AIC.mmkin</a></code>.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Compare the AIC of columns of <code><a href="mmkin.html">mmkin</a></code> objects using +<code><a href="AIC.mmkin.html">AIC.mmkin</a></code>.</p></div> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='co'># \dontrun{</span> - <span class='va'>sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span> - <span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='va'>d_t</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span> - <span class='va'>f_nw</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>sfo_sfo</span>, <span class='va'>d_t</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> <span class='co'># no weighting (weights are unity)</span> - <span class='va'>f_obs</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_nw</span>, error_model <span class='op'>=</span> <span class='st'>"obs"</span><span class='op'>)</span> - <span class='va'>f_tc</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_nw</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f_nw</span>, <span class='va'>f_obs</span>, <span class='va'>f_tc</span><span class='op'>)</span> -</div><div class='output co'>#> df AIC -#> f_nw 5 204.4486 -#> f_obs 6 205.8727 -#> f_tc 6 141.9656</div><div class='input'> <span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span></span> +<span class="r-in"> <span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="va">d_t</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_nw</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">sfo_sfo</span>, <span class="va">d_t</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="co"># no weighting (weights are unity)</span></span> +<span class="r-in"> <span class="va">f_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_nw</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_nw</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nw</span>, <span class="va">f_obs</span>, <span class="va">f_tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> f_nw 5 204.4486</span> +<span class="r-out co"><span class="r-pr">#></span> f_obs 6 205.8727</span> +<span class="r-out co"><span class="r-pr">#></span> f_tc 6 141.9656</span> +<span class="r-in"> <span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/logistic.solution-1.png b/docs/reference/logistic.solution-1.png Binary files differindex 84d8e722..73dad0a4 100644 --- a/docs/reference/logistic.solution-1.png +++ b/docs/reference/logistic.solution-1.png diff --git a/docs/reference/logistic.solution-2.png b/docs/reference/logistic.solution-2.png Binary files 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data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ an increasing rate constant, supposedly caused by microbial growth" /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ an increasing rate constant, supposedly caused by microbial growth" /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ an increasing rate constant, supposedly caused by microbial growth" /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ an increasing rate constant, supposedly caused by microbial growth" /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Logistic kinetics</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parent_solutions.R'><code>R/parent_solutions.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> <div class="hidden name"><code>logistic.solution.Rd</code></div> </div> @@ -149,136 +88,132 @@ an increasing rate constant, supposedly caused by microbial growth" /> an increasing rate constant, supposedly caused by microbial growth</p> </div> - <pre class="usage"><span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>t</span>, <span class='va'>parent_0</span>, <span class='va'>kmax</span>, <span class='va'>k0</span>, <span class='va'>r</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>t</th> - <td><p>Time.</p></td> - </tr> - <tr> - <th>parent_0</th> - <td><p>Starting value for the response variable at time zero.</p></td> - </tr> - <tr> - <th>kmax</th> - <td><p>Maximum rate constant.</p></td> - </tr> - <tr> - <th>k0</th> - <td><p>Minimum rate constant effective at time zero.</p></td> - </tr> - <tr> - <th>r</th> - <td><p>Growth rate of the increase in the rate constant.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">logistic.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">kmax</span>, <span class="va">k0</span>, <span class="va">r</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>t</dt> +<dd><p>Time.</p></dd> +<dt>parent_0</dt> +<dd><p>Starting value for the response variable at time zero.</p></dd> +<dt>kmax</dt> +<dd><p>Maximum rate constant.</p></dd> +<dt>k0</dt> +<dd><p>Minimum rate constant effective at time zero.</p></dd> +<dt>r</dt> +<dd><p>Growth rate of the increase in the rate constant.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The value of the response variable at time <code>t</code>.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - + </div> + <div id="note"> + <h2>Note</h2> <p>The solution of the logistic model reduces to the -<code><a href='SFO.solution.html'>SFO.solution</a></code> if <code>k0</code> is equal to <code>kmax</code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence +<code><a href="SFO.solution.html">SFO.solution</a></code> if <code>k0</code> is equal to <code>kmax</code>.</p> + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> +FOCUS (2014) “Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, Version 1.1, 18 December 2014 -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p>Other parent solutions: -<code><a href='DFOP.solution.html'>DFOP.solution</a>()</code>, -<code><a href='FOMC.solution.html'>FOMC.solution</a>()</code>, -<code><a href='HS.solution.html'>HS.solution</a>()</code>, -<code><a href='IORE.solution.html'>IORE.solution</a>()</code>, -<code><a href='SFO.solution.html'>SFO.solution</a>()</code>, -<code><a href='SFORB.solution.html'>SFORB.solution</a>()</code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='co'># Reproduce the plot on page 57 of FOCUS (2014)</span> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.2</span><span class='op'>)</span>, - from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, ylim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>100</span><span class='op'>)</span>, - xlab <span class='op'>=</span> <span class='st'>"Time"</span>, ylab <span class='op'>=</span> <span class='st'>"Residue"</span><span class='op'>)</span> -</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.4</span><span class='op'>)</span>, - from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>2</span>, col <span class='op'>=</span> <span class='fl'>2</span><span class='op'>)</span> -</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.8</span><span class='op'>)</span>, - from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>3</span>, col <span class='op'>=</span> <span class='fl'>3</span><span class='op'>)</span> -</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.001</span>, <span class='fl'>0.2</span><span class='op'>)</span>, - from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>4</span>, col <span class='op'>=</span> <span class='fl'>4</span><span class='op'>)</span> -</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'>logistic.solution</span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>100</span>, <span class='fl'>0.08</span>, <span class='fl'>0.08</span>, <span class='fl'>0.2</span><span class='op'>)</span>, - from <span class='op'>=</span> <span class='fl'>0</span>, to <span class='op'>=</span> <span class='fl'>100</span>, add <span class='op'>=</span> <span class='cn'>TRUE</span>, lty <span class='op'>=</span> <span class='fl'>5</span>, col <span class='op'>=</span> <span class='fl'>5</span><span class='op'>)</span> -</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></span><span class='op'>(</span><span class='st'>"topright"</span>, inset <span class='op'>=</span> <span class='fl'>0.05</span>, - legend <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='st'>"k0 = "</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.0001</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.0001</span>, <span class='fl'>0.001</span>, <span class='fl'>0.08</span><span class='op'>)</span>, - <span class='st'>", r = "</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.2</span>, <span class='fl'>0.4</span>, <span class='fl'>0.8</span>, <span class='fl'>0.2</span>, <span class='fl'>0.2</span><span class='op'>)</span><span class='op'>)</span>, - lty <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span>, col <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span><span class='op'>)</span> -</div><div class='img'><img src='logistic.solution-1.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='co'># Fit with synthetic data</span> - <span class='va'>logistic</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"logistic"</span><span class='op'>)</span><span class='op'>)</span> - - <span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> - <span class='va'>parms_logistic</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>kmax <span class='op'>=</span> <span class='fl'>0.08</span>, k0 <span class='op'>=</span> <span class='fl'>0.0001</span>, r <span class='op'>=</span> <span class='fl'>0.2</span><span class='op'>)</span> - <span class='va'>d_logistic</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>logistic</span>, - <span class='va'>parms_logistic</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - <span class='va'>d_2_1</span> <span class='op'><-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_logistic</span>, - sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'><a href='sigma_twocomp.html'>sigma_twocomp</a></span><span class='op'>(</span><span class='va'>x</span>, <span class='fl'>0.5</span>, <span class='fl'>0.07</span><span class='op'>)</span>, - n <span class='op'>=</span> <span class='fl'>1</span>, reps <span class='op'>=</span> <span class='fl'>2</span>, digits <span class='op'>=</span> <span class='fl'>5</span>, LOD <span class='op'>=</span> <span class='fl'>0.1</span>, seed <span class='op'>=</span> <span class='fl'>123456</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p>Other parent solutions: +<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, +<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, +<code><a href="HS.solution.html">HS.solution</a>()</code>, +<code><a href="IORE.solution.html">IORE.solution</a>()</code>, +<code><a href="SFO.solution.html">SFO.solution</a>()</code>, +<code><a href="SFORB.solution.html">SFORB.solution</a>()</code></p></div> + </div> - <span class='va'>m</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"logistic"</span>, <span class='va'>d_2_1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span> -</div><div class='img'><img src='logistic.solution-2.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower -#> parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02 -#> kmax 6.398190e-02 0.0143201029 4.467978 3.841828e-04 3.929235e-02 -#> k0 1.612775e-04 0.0005866813 0.274898 3.940351e-01 5.846688e-08 -#> r 2.263946e-01 0.1718110662 1.317695 1.061043e-01 4.335843e-02 -#> sigma 5.332935e+00 0.9145907310 5.830952 4.036926e-05 3.340213e+00 -#> Upper -#> parent_0 109.9341588 -#> kmax 0.1041853 -#> k0 0.4448749 -#> r 1.1821120 -#> sigma 7.3256566</div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>m</span><span class='op'>)</span><span class='op'>$</span><span class='va'>distimes</span> -</div><div class='output co'>#> DT50 DT90 DT50_k0 DT50_kmax -#> parent 36.86533 62.41511 4297.853 10.83349</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="co"># Reproduce the plot on page 57 of FOCUS (2014)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span> +<span class="r-in"> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span>,</span> +<span class="r-in"> xlab <span class="op">=</span> <span class="st">"Time"</span>, ylab <span class="op">=</span> <span class="st">"Residue"</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.4</span><span class="op">)</span>,</span> +<span class="r-in"> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">2</span>, col <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.8</span><span class="op">)</span>,</span> +<span class="r-in"> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">3</span>, col <span class="op">=</span> <span class="fl">3</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span> +<span class="r-in"> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">4</span>, col <span class="op">=</span> <span class="fl">4</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.08</span>, <span class="fl">0.2</span><span class="op">)</span>,</span> +<span class="r-in"> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">5</span>, col <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></span><span class="op">(</span><span class="st">"topright"</span>, inset <span class="op">=</span> <span class="fl">0.05</span>,</span> +<span class="r-in"> legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"k0 = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.001</span>, <span class="fl">0.08</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="st">", r = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.2</span>, <span class="fl">0.4</span>, <span class="fl">0.8</span>, <span class="fl">0.2</span>, <span class="fl">0.2</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> lty <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, col <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span> +<span class="r-plt img"><img src="logistic.solution-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># Fit with synthetic data</span></span> +<span class="r-in"> <span class="va">logistic</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"logistic"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">parms_logistic</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>kmax <span class="op">=</span> <span class="fl">0.08</span>, k0 <span class="op">=</span> <span class="fl">0.0001</span>, r <span class="op">=</span> <span class="fl">0.2</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">d_logistic</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">logistic</span>,</span> +<span class="r-in"> <span class="va">parms_logistic</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">d_2_1</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_logistic</span>,</span> +<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="sigma_twocomp.html">sigma_twocomp</a></span><span class="op">(</span><span class="va">x</span>, <span class="fl">0.5</span>, <span class="fl">0.07</span><span class="op">)</span>,</span> +<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span>, reps <span class="op">=</span> <span class="fl">2</span>, digits <span class="op">=</span> <span class="fl">5</span>, LOD <span class="op">=</span> <span class="fl">0.1</span>, seed <span class="op">=</span> <span class="fl">123456</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">m</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"logistic"</span>, <span class="va">d_2_1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span></span> +<span class="r-plt img"><img src="logistic.solution-2.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02</span> +<span class="r-out co"><span class="r-pr">#></span> kmax 6.398190e-02 0.0143201029 4.467978 3.841828e-04 3.929235e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k0 1.612775e-04 0.0005866813 0.274898 3.940351e-01 5.846688e-08</span> +<span class="r-out co"><span class="r-pr">#></span> r 2.263946e-01 0.1718110662 1.317695 1.061043e-01 4.335843e-02</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.332935e+00 0.9145907310 5.830952 4.036926e-05 3.340213e+00</span> +<span class="r-out co"><span class="r-pr">#></span> Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 109.9341588</span> +<span class="r-out co"><span class="r-pr">#></span> kmax 0.1041853</span> +<span class="r-out co"><span class="r-pr">#></span> k0 0.4448749</span> +<span class="r-out co"><span class="r-pr">#></span> r 1.1821120</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 7.3256566</span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span></span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_k0 DT50_kmax</span> +<span class="r-out co"><span class="r-pr">#></span> parent 36.86533 62.41511 4297.853 10.83349</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/lrtest.mkinfit.html b/docs/reference/lrtest.mkinfit.html index d670fb0c..d4355c43 100644 --- a/docs/reference/lrtest.mkinfit.html +++ b/docs/reference/lrtest.mkinfit.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Likelihood ratio test for mkinfit models — lrtest.mkinfit • mkin</title> - - -<!-- jquery --> -<script 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If two fitted +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Likelihood ratio test for mkinfit models — lrtest.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Likelihood ratio test for mkinfit models — lrtest.mkinfit"><meta property="og:description" content="Compare two mkinfit models based on their likelihood. If two fitted mkinfit objects are given as arguments, it is checked if they have been fitted to the same data. It is the responsibility of the user to make sure that the models are nested, i.e. one of them has less degrees of freedom -and can be expressed by fixing the parameters of the other." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +and can be expressed by fixing the parameters of the other."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ and can be expressed by fixing the parameters of the other." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ and can be expressed by fixing the parameters of the other." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ and can be expressed by fixing the parameters of the other." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,34 +62,27 @@ and can be expressed by fixing the parameters of the other." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Likelihood ratio test for mkinfit models</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/lrtest.mkinfit.R'><code>R/lrtest.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/lrtest.mkinfit.R" class="external-link"><code>R/lrtest.mkinfit.R</code></a></small> <div class="hidden name"><code>lrtest.mkinfit.Rd</code></div> </div> @@ -155,115 +94,112 @@ that the models are nested, i.e. one of them has less degrees of freedom and can be expressed by fixing the parameters of the other.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>object</span>, object_2 <span class='op'>=</span> <span class='cn'>NULL</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An <code><a href='mkinfit.html'>mkinfit</a></code> object, or an <code><a href='mmkin.html'>mmkin</a></code> column -object containing two fits to the same data.</p></td> - </tr> - <tr> - <th>object_2</th> - <td><p>Optionally, another mkinfit object fitted to the same data.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Argument to <code><a href='mkinfit.html'>mkinfit</a></code>, passed to -<code><a href='update.mkinfit.html'>update.mkinfit</a></code> for creating the alternative fitted object.</p></td> - </tr> - </table> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">object</span>, object_2 <span class="op">=</span> <span class="cn">NULL</span>, <span class="va">...</span><span class="op">)</span> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> +<span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <code><a href="mkinfit.html">mkinfit</a></code> object, or an <code><a href="mmkin.html">mmkin</a></code> column +object containing two fits to the same data.</p></dd> +<dt>object_2</dt> +<dd><p>Optionally, another mkinfit object fitted to the same data.</p></dd> +<dt>...</dt> +<dd><p>Argument to <code><a href="mkinfit.html">mkinfit</a></code>, passed to +<code><a href="update.mkinfit.html">update.mkinfit</a></code> for creating the alternative fitted object.</p></dd> +</dl></div> + <div id="details"> + <h2>Details</h2> <p>Alternatively, an argument to mkinfit can be given which is then passed -to <code><a href='update.mkinfit.html'>update.mkinfit</a></code> to obtain the alternative model.</p> -<p>The comparison is then made by the <code><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest.default</a></code> +to <code><a href="update.mkinfit.html">update.mkinfit</a></code> to obtain the alternative model.</p> +<p>The comparison is then made by the <code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest.default</a></code> method from the lmtest package. The model with the higher number of fitted parameters (alternative hypothesis) is listed first, then the model with the lower number of fitted parameters (null hypothesis).</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> -<span class='va'>test_data</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>12</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, <span class='va'>name</span> <span class='op'>==</span> <span class='st'>"parent"</span><span class='op'>)</span> -<span class='va'>sfo_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>test_data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>dfop_fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>test_data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>dfop_fit</span>, <span class='va'>sfo_fit</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: DFOP with error model const -#> Model 2: SFO with error model const -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 5 -42.453 -#> 2 3 -63.954 -2 43.002 4.594e-10 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>sfo_fit</span>, <span class='va'>dfop_fit</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: DFOP with error model const -#> Model 2: SFO with error model const -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 5 -42.453 -#> 2 3 -63.954 -2 43.002 4.594e-10 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'> -<span class='co'># The following two examples are commented out as they fail during</span> -<span class='co'># generation of the static help pages by pkgdown</span> -<span class='co'>#lrtest(dfop_fit, error_model = "tc")</span> -<span class='co'>#lrtest(dfop_fit, fixed_parms = c(k2 = 0))</span> - -<span class='co'># However, this equivalent syntax also works for static help pages</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>dfop_fit</span>, <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>dfop_fit</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: DFOP with error model tc -#> Model 2: DFOP with error model const -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 6 -34.587 -#> 2 5 -42.453 -1 15.731 7.302e-05 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>dfop_fit</span>, <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>dfop_fit</span>, fixed_parms <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k2 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: DFOP with error model const -#> Model 2: DFOP with error model const and fixed parameter(s) k2 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 5 -42.453 -#> 2 4 -57.340 -1 29.776 4.851e-08 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">test_data</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">sfo_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dfop_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="va">sfo_fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -2 43.002 4.594e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">sfo_fit</span>, <span class="va">dfop_fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -2 43.002 4.594e-10 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The following two examples are commented out as they fail during</span></span> +<span class="r-in"><span class="co"># generation of the static help pages by pkgdown</span></span> +<span class="r-in"><span class="co">#lrtest(dfop_fit, error_model = "tc")</span></span> +<span class="r-in"><span class="co">#lrtest(dfop_fit, fixed_parms = c(k2 = 0))</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># However, this equivalent syntax also works for static help pages</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">dfop_fit</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model tc</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 6 -34.587 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 5 -42.453 -1 15.731 7.302e-05 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">dfop_fit</span>, fixed_parms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const and fixed parameter(s) k2</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 4 -57.340 -1 29.776 4.851e-08 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + 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Currently, only calculations for the parent are implemented for the SFO, FOMC, DFOP and HS models, using the analytical formulas given in the PEC -soil section of the FOCUS guidance." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +soil section of the FOCUS guidance."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -78,13 +23,12 @@ soil section of the FOCUS guidance." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -93,8 +37,7 @@ soil section of the FOCUS guidance." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -104,6 +47,9 @@ soil section of the FOCUS guidance." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -118,157 +64,130 @@ soil section of the FOCUS guidance." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to calculate maximum time weighted average concentrations from kinetic models fitted with mkinfit</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/max_twa_parent.R'><code>R/max_twa_parent.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/max_twa_parent.R" class="external-link"><code>R/max_twa_parent.R</code></a></small> <div class="hidden name"><code>max_twa_parent.Rd</code></div> </div> <div class="ref-description"> <p>This function calculates maximum moving window time weighted average -concentrations (TWAs) for kinetic models fitted with <code><a href='mkinfit.html'>mkinfit</a></code>. +concentrations (TWAs) for kinetic models fitted with <code><a href="mkinfit.html">mkinfit</a></code>. Currently, only calculations for the parent are implemented for the SFO, FOMC, DFOP and HS models, using the analytical formulas given in the PEC soil section of the FOCUS guidance.</p> </div> - <pre class="usage"><span class='fu'>max_twa_parent</span><span class='op'>(</span><span class='va'>fit</span>, <span class='va'>windows</span><span class='op'>)</span> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">max_twa_parent</span><span class="op">(</span><span class="va">fit</span>, <span class="va">windows</span><span class="op">)</span> -<span class='fu'>max_twa_sfo</span><span class='op'>(</span>M0 <span class='op'>=</span> <span class='fl'>1</span>, <span class='va'>k</span>, <span class='va'>t</span><span class='op'>)</span> +<span class="fu">max_twa_sfo</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k</span>, <span class="va">t</span><span class="op">)</span> -<span class='fu'>max_twa_fomc</span><span class='op'>(</span>M0 <span class='op'>=</span> <span class='fl'>1</span>, <span class='va'>alpha</span>, <span class='va'>beta</span>, <span class='va'>t</span><span class='op'>)</span> +<span class="fu">max_twa_fomc</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">alpha</span>, <span class="va">beta</span>, <span class="va">t</span><span class="op">)</span> -<span class='fu'>max_twa_dfop</span><span class='op'>(</span>M0 <span class='op'>=</span> <span class='fl'>1</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>g</span>, <span class='va'>t</span><span class='op'>)</span> +<span class="fu">max_twa_dfop</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">t</span><span class="op">)</span> -<span class='fu'>max_twa_hs</span><span class='op'>(</span>M0 <span class='op'>=</span> <span class='fl'>1</span>, <span class='va'>k1</span>, <span class='va'>k2</span>, <span class='va'>tb</span>, <span class='va'>t</span><span class='op'>)</span></pre> +<span class="fu">max_twa_hs</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">tb</span>, <span class="va">t</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>fit</th> - <td><p>An object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>windows</th> - <td><p>The width of the time windows for which the TWAs should be -calculated.</p></td> - </tr> - <tr> - <th>M0</th> - <td><p>The initial concentration for which the maximum time weighted + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>fit</dt> +<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>windows</dt> +<dd><p>The width of the time windows for which the TWAs should be +calculated.</p></dd> +<dt>M0</dt> +<dd><p>The initial concentration for which the maximum time weighted average over the decline curve should be calculated. The default is to use a value of 1, which means that a relative maximum time weighted average -factor (f_twa) is calculated.</p></td> - </tr> - <tr> - <th>k</th> - <td><p>The rate constant in the case of SFO kinetics.</p></td> - </tr> - <tr> - <th>t</th> - <td><p>The width of the time window.</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>Parameter of the FOMC model.</p></td> - </tr> - <tr> - <th>beta</th> - <td><p>Parameter of the FOMC model.</p></td> - </tr> - <tr> - <th>k1</th> - <td><p>The first rate constant of the DFOP or the HS kinetics.</p></td> - </tr> - <tr> - <th>k2</th> - <td><p>The second rate constant of the DFOP or the HS kinetics.</p></td> - </tr> - <tr> - <th>g</th> - <td><p>Parameter of the DFOP model.</p></td> - </tr> - <tr> - <th>tb</th> - <td><p>Parameter of the HS model.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +factor (f_twa) is calculated.</p></dd> +<dt>k</dt> +<dd><p>The rate constant in the case of SFO kinetics.</p></dd> +<dt>t</dt> +<dd><p>The width of the time window.</p></dd> +<dt>alpha</dt> +<dd><p>Parameter of the FOMC model.</p></dd> +<dt>beta</dt> +<dd><p>Parameter of the FOMC model.</p></dd> +<dt>k1</dt> +<dd><p>The first rate constant of the DFOP or the HS kinetics.</p></dd> +<dt>k2</dt> +<dd><p>The second rate constant of the DFOP or the HS kinetics.</p></dd> +<dt>g</dt> +<dd><p>Parameter of the DFOP model.</p></dd> +<dt>tb</dt> +<dd><p>Parameter of the HS model.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>For <code>max_twa_parent</code>, a numeric vector, named using the <code>windows</code> argument. For the other functions, a numeric vector of length one (also known as 'a number').</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'>max_twa_parent</span><span class='op'>(</span><span class='va'>fit</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>7</span>, <span class='fl'>21</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> 7 21 -#> 34.71343 18.22124 </div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu">max_twa_parent</span><span class="op">(</span><span class="va">fit</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">7</span>, <span class="fl">21</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> 7 21 </span> +<span class="r-out co"><span class="r-pr">#></span> 34.71343 18.22124 </span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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<ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,30 +60,23 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Datasets on aerobic soil metabolism of 2,4,5-T in six soils</h1> @@ -151,120 +90,133 @@ extracts.</p> </div> - <pre class="usage"><span class='va'>mccall81_245T</span></pre> - - - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">mccall81_245T</span></code></pre></div> + </div> - <p>A dataframe containing the following variables.</p><dl> - <dt><code>name</code></dt><dd><p>the name of the compound observed. Note that T245 is used as + <div id="format"> + <h2>Format</h2> + <p>A dataframe containing the following variables.</p><dl><dt><code>name</code></dt> +<dd><p>the name of the compound observed. Note that T245 is used as an acronym for 2,4,5-T. T245 is a legitimate object name in R, which is necessary for specifying models using - <code><a href='mkinmod.html'>mkinmod</a></code>.</p></dd> - <dt><code>time</code></dt><dd><p>a numeric vector containing sampling times in days after + <code><a href="mkinmod.html">mkinmod</a></code>.</p></dd> + + <dt><code>time</code></dt> +<dd><p>a numeric vector containing sampling times in days after treatment</p></dd> - <dt><code>value</code></dt><dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> - <dt><code>soil</code></dt><dd><p>a factor containing the name of the soil</p></dd> - -</dl> - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> + <dt><code>value</code></dt> +<dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> + + <dt><code>soil</code></dt> +<dd><p>a factor containing the name of the soil</p></dd> + +</dl></div> + <div id="source"> + <h2>Source</h2> <p>McCall P, Vrona SA, Kelley SS (1981) Fate of uniformly carbon-14 ring labelled 2,4,5-Trichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid. J Agric Chem 29, 100-107 - doi: <a href='https://doi.org/10.1021/jf00103a026'>10.1021/jf00103a026</a></p> + doi: <a href="https://doi.org/10.1021/jf00103a026" class="external-link">10.1021/jf00103a026</a></p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> <span class='va'>SFO_SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>T245 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"phenol"</span><span class='op'>)</span>, - phenol <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"anisole"</span><span class='op'>)</span>, - anisole <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='co'># \dontrun{</span> - <span class='va'>fit.1</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO_SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>mccall81_245T</span>, <span class='va'>soil</span> <span class='op'>==</span> <span class='st'>"Commerce"</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.1</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) -#> T245_0 1.038550e+02 2.1847074945 47.537272 4.472189e-18 -#> k_T245 4.337042e-02 0.0018983965 22.845818 2.276911e-13 -#> k_phenol 4.050581e-01 0.2986993563 1.356073 9.756989e-02 -#> k_anisole 6.678742e-03 0.0008021439 8.326114 2.623177e-07 -#> f_T245_to_phenol 6.227599e-01 0.3985340558 1.562627 6.949413e-02 -#> f_phenol_to_anisole 1.000000e+00 0.6718439825 1.488441 7.867789e-02 -#> sigma 2.514628e+00 0.4907558883 5.123989 6.233157e-05 -#> Lower Upper -#> T245_0 99.246061385 1.084640e+02 -#> k_T245 0.039631621 4.746194e-02 -#> k_phenol 0.218013879 7.525762e-01 -#> k_anisole 0.005370739 8.305299e-03 -#> f_T245_to_phenol 0.547559081 6.924813e-01 -#> f_phenol_to_anisole 0.000000000 1.000000e+00 -#> sigma 1.706607296 3.322649e+00</div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.1</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> T245_phenol T245_sink phenol_anisole phenol_sink -#> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 -#> -#> $distimes -#> DT50 DT90 -#> T245 15.982025 53.09114 -#> phenol 1.711229 5.68458 -#> anisole 103.784093 344.76329 -#> </div><div class='input'> <span class='co'># formation fraction from phenol to anisol is practically 1. As we cannot</span> - <span class='co'># fix formation fractions when using the ilr transformation, we can turn of</span> - <span class='co'># the sink in the model generation</span> - <span class='va'>SFO_SFO_SFO_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>T245 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"phenol"</span><span class='op'>)</span>, - phenol <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"anisole"</span>, sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - anisole <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='va'>fit.2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO_SFO_2</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>mccall81_245T</span>, <span class='va'>soil</span> <span class='op'>==</span> <span class='st'>"Commerce"</span><span class='op'>)</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.2</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower -#> T245_0 1.038550e+02 2.1623653066 48.028439 4.993108e-19 99.271020284 -#> k_T245 4.337042e-02 0.0018343666 23.643268 3.573556e-14 0.039650976 -#> k_phenol 4.050582e-01 0.1177237473 3.440752 1.679254e-03 0.218746587 -#> k_anisole 6.678742e-03 0.0006829745 9.778903 1.872894e-08 0.005377083 -#> f_T245_to_phenol 6.227599e-01 0.0342197875 18.198824 2.039411e-12 0.547975637 -#> sigma 2.514628e+00 0.3790944250 6.633250 2.875782e-06 1.710983655 -#> Upper -#> T245_0 108.43904074 -#> k_T245 0.04743877 -#> k_phenol 0.75005585 -#> k_anisole 0.00829550 -#> f_T245_to_phenol 0.69212308 -#> sigma 3.31827222</div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.1</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> T245_phenol T245_sink phenol_anisole phenol_sink -#> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 -#> -#> $distimes -#> DT50 DT90 -#> T245 15.982025 53.09114 -#> phenol 1.711229 5.68458 -#> anisole 103.784093 344.76329 -#> </div><div class='input'> <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>fit.2</span><span class='op'>)</span> -</div><div class='img'><img src='mccall81_245T-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"> <span class="va">SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>T245 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"phenol"</span><span class="op">)</span>,</span> +<span class="r-in"> phenol <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"anisole"</span><span class="op">)</span>,</span> +<span class="r-in"> anisole <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit.1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO_SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t)</span> +<span class="r-out co"><span class="r-pr">#></span> T245_0 1.038550e+02 2.1847074945 47.537272 4.472189e-18</span> +<span class="r-out co"><span class="r-pr">#></span> k_T245 4.337042e-02 0.0018983965 22.845818 2.276911e-13</span> +<span class="r-out co"><span class="r-pr">#></span> k_phenol 4.050581e-01 0.2986993563 1.356073 9.756989e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_anisole 6.678742e-03 0.0008021439 8.326114 2.623177e-07</span> +<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 6.227599e-01 0.3985340558 1.562627 6.949413e-02</span> +<span class="r-out co"><span class="r-pr">#></span> f_phenol_to_anisole 1.000000e+00 0.6718439825 1.488441 7.867789e-02</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.514628e+00 0.4907558883 5.123989 6.233157e-05</span> +<span class="r-out co"><span class="r-pr">#></span> Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> T245_0 99.246061385 1.084640e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_T245 0.039631621 4.746194e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_phenol 0.218013879 7.525762e-01</span> +<span class="r-out co"><span class="r-pr">#></span> k_anisole 0.005370739 8.305299e-03</span> +<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 0.547559081 6.924813e-01</span> +<span class="r-out co"><span class="r-pr">#></span> f_phenol_to_anisole 0.000000000 1.000000e+00</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.706607296 3.322649e+00</span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> T245_phenol T245_sink phenol_anisole phenol_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> T245 15.982025 53.09114</span> +<span class="r-out co"><span class="r-pr">#></span> phenol 1.711229 5.68458</span> +<span class="r-out co"><span class="r-pr">#></span> anisole 103.784093 344.76329</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="co"># formation fraction from phenol to anisol is practically 1. As we cannot</span></span> +<span class="r-in"> <span class="co"># fix formation fractions when using the ilr transformation, we can turn of</span></span> +<span class="r-in"> <span class="co"># the sink in the model generation</span></span> +<span class="r-in"> <span class="va">SFO_SFO_SFO_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>T245 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"phenol"</span><span class="op">)</span>,</span> +<span class="r-in"> phenol <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"anisole"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> anisole <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="va">fit.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO_SFO_2</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> +<span class="r-out co"><span class="r-pr">#></span> T245_0 1.038550e+02 2.1623653066 48.028439 4.993108e-19 99.271020284</span> +<span class="r-out co"><span class="r-pr">#></span> k_T245 4.337042e-02 0.0018343666 23.643268 3.573556e-14 0.039650976</span> +<span class="r-out co"><span class="r-pr">#></span> k_phenol 4.050582e-01 0.1177237473 3.440752 1.679254e-03 0.218746587</span> +<span class="r-out co"><span class="r-pr">#></span> k_anisole 6.678742e-03 0.0006829745 9.778903 1.872894e-08 0.005377083</span> +<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 6.227599e-01 0.0342197875 18.198824 2.039411e-12 0.547975637</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.514628e+00 0.3790944250 6.633250 2.875782e-06 1.710983655</span> +<span class="r-out co"><span class="r-pr">#></span> Upper</span> +<span class="r-out co"><span class="r-pr">#></span> T245_0 108.43904074</span> +<span class="r-out co"><span class="r-pr">#></span> k_T245 0.04743877</span> +<span class="r-out co"><span class="r-pr">#></span> k_phenol 0.75005585</span> +<span class="r-out co"><span class="r-pr">#></span> k_anisole 0.00829550</span> +<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 0.69212308</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.31827222</span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> T245_phenol T245_sink phenol_anisole phenol_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> T245 15.982025 53.09114</span> +<span class="r-out co"><span class="r-pr">#></span> phenol 1.711229 5.68458</span> +<span class="r-out co"><span class="r-pr">#></span> anisole 103.784093 344.76329</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mccall81_245T-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mean_degparms.html 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title="Released version">1.1.0</span> + </span> + </div> + + <div id="navbar" class="navbar-collapse collapse"> + <ul class="nav navbar-nav"><li> + <a href="../reference/index.html">Functions and data</a> +</li> +<li class="dropdown"> + <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + Articles + + <span class="caret"></span> + </a> + <ul class="dropdown-menu" role="menu"><li> + <a href="../articles/mkin.html">Introduction to mkin</a> + </li> + <li> + <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + </li> + <li> + <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Calculate mean degradation parameters for an mmkin row object</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mean_degparms.R" class="external-link"><code>R/mean_degparms.R</code></a></small> + <div class="hidden name"><code>mean_degparms.Rd</code></div> + </div> + + <div class="ref-description"> + <p>Calculate mean degradation parameters for an mmkin row object</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mean_degparms</span><span class="op">(</span><span class="va">object</span>, random <span class="op">=</span> <span class="cn">FALSE</span>, test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>, conf.level <span class="op">=</span> <span class="fl">0.6</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An mmkin row object containing several fits of the same model to different datasets</p></dd> +<dt>random</dt> +<dd><p>Should a list with fixed and random effects be returned?</p></dd> +<dt>test_log_parms</dt> +<dd><p>If TRUE, log parameters are only considered in +the mean calculations if their untransformed counterparts (most likely +rate constants) pass the t-test for significant difference from zero.</p></dd> +<dt>conf.level</dt> +<dd><p>Possibility to adjust the required confidence level +for parameter that are tested if requested by 'test_log_parms'.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>If random is FALSE (default), a named vector containing mean values +of the fitted degradation model parameters. If random is TRUE, a list with +fixed and random effects, in the format required by the start argument of +nlme for the case of a single grouping variable ds.</p> + </div> + + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/mixed-1.png b/docs/reference/mixed-1.png Binary files differindex 422ab6a0..54b81b70 100644 --- a/docs/reference/mixed-1.png +++ b/docs/reference/mixed-1.png diff --git a/docs/reference/mixed.html b/docs/reference/mixed.html index b3bf35bf..dc0d1681 100644 --- a/docs/reference/mixed.html +++ b/docs/reference/mixed.html @@ -1,67 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data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -72,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Create a mixed effects model from an mmkin row object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mixed.mmkin.R'><code>R/mixed.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mixed.mmkin.R" class="external-link"><code>R/mixed.mmkin.R</code></a></small> <div class="hidden name"><code>mixed.Rd</code></div> </div> @@ -147,131 +86,126 @@ <p>Create a mixed effects model from an mmkin row object</p> </div> - <pre class="usage"><span class='fu'>mixed</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for mmkin</span> -<span class='fu'>mixed</span><span class='op'>(</span><span class='va'>object</span>, method <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"none"</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for mixed.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An <a href='mmkin.html'>mmkin</a> row object</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Currently not used</p></td> - </tr> - <tr> - <th>method</th> - <td><p>The method to be used</p></td> - </tr> - <tr> - <th>x</th> - <td><p>A mixed.mmkin object to print</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>Number of digits to use for printing.</p></td> - </tr> - </table> +<span class="co"># S3 method for mmkin</span> +<span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"none"</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span> +<span class="co"># S3 method for mixed.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> -<span class='va'>n_biphasic</span> <span class='op'><-</span> <span class='fl'>8</span> -<span class='va'>err_1</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>const <span class='op'>=</span> <span class='fl'>1</span>, prop <span class='op'>=</span> <span class='fl'>0.07</span><span class='op'>)</span> - -<span class='va'>DFOP_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - -<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>123456</span><span class='op'>)</span> -<span class='va'>log_sd</span> <span class='op'><-</span> <span class='fl'>0.3</span> -<span class='va'>syn_biphasic_parms</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/matrix.html'>as.matrix</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span> - k1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.05</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span>, - k2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.01</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span>, - g <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Logistic.html'>plogis</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/stats/Normal.html'>rnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fl'>0</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span>, - f_parent_to_m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Logistic.html'>plogis</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/stats/Normal.html'>rnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fl'>0</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span>, - k_m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='va'>n_biphasic</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>0.002</span><span class='op'>)</span>, <span class='va'>log_sd</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> - -<span class='va'>ds_biphasic_mean</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='fl'>1</span><span class='op'>:</span><span class='va'>n_biphasic</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>DFOP_SFO</span>, <span class='va'>syn_biphasic_parms</span><span class='op'>[</span><span class='va'>i</span>, <span class='op'>]</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='va'>sampling_times</span><span class='op'>)</span> - <span class='op'>}</span> -<span class='op'>)</span> - -<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>123456L</span><span class='op'>)</span> -<span class='va'>ds_biphasic</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>ds_biphasic_mean</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>ds</span>, - sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>sqrt</a></span><span class='op'>(</span><span class='va'>err_1</span><span class='op'>$</span><span class='va'>const</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>+</span> <span class='va'>value</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>*</span> <span class='va'>err_1</span><span class='op'>$</span><span class='va'>prop</span><span class='op'>^</span><span class='fl'>2</span><span class='op'>)</span>, - n <span class='op'>=</span> <span class='fl'>1</span>, secondary <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span> -<span class='op'>}</span><span class='op'>)</span> - -<span class='co'># \dontrun{</span> -<span class='va'>f_mmkin</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"DFOP-SFO"</span> <span class='op'>=</span> <span class='va'>DFOP_SFO</span><span class='op'>)</span>, <span class='va'>ds_biphasic</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <a href="mmkin.html">mmkin</a> row object</p></dd> +<dt>...</dt> +<dd><p>Currently not used</p></dd> +<dt>method</dt> +<dd><p>The method to be used</p></dd> +<dt>x</dt> +<dd><p>A mixed.mmkin object to print</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An object of class 'mixed.mmkin' which has the observed data in a +single dataframe which is convenient for plotting</p> + </div> -<span class='va'>f_mixed</span> <span class='op'><-</span> <span class='fu'>mixed</span><span class='op'>(</span><span class='va'>f_mmkin</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f_mixed</span><span class='op'>)</span> -</div><div class='output co'>#> Kinetic model fitted by nonlinear regression to each dataset -#> Structural model: -#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -#> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -#> * parent -#> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) -#> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * -#> exp(-k2 * time))) * parent - k_m1 * m1 -#> -#> Data: -#> 271 observations of 2 variable(s) grouped in 8 datasets -#> -#> <mmkin> object -#> Status of individual fits: -#> -#> dataset -#> model 1 2 3 4 5 6 7 8 -#> DFOP-SFO OK OK OK OK OK OK OK OK -#> -#> OK: No warnings -#> -#> Mean fitted parameters: -#> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 -#> 100.674757 -8.761916 -0.004347 -3.348812 -3.986853 -#> g_qlogis -#> -0.087392 </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_mixed</span><span class='op'>)</span> -</div><div class='img'><img src='mixed-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">n_biphasic</span> <span class="op"><-</span> <span class="fl">8</span></span> +<span class="r-in"><span class="va">err_1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>const <span class="op">=</span> <span class="fl">1</span>, prop <span class="op">=</span> <span class="fl">0.07</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456</span><span class="op">)</span></span> +<span class="r-in"><span class="va">log_sd</span> <span class="op"><-</span> <span class="fl">0.3</span></span> +<span class="r-in"><span class="va">syn_biphasic_parms</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">as.matrix</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> +<span class="r-in"> k1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.05</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span> +<span class="r-in"> k2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.01</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span> +<span class="r-in"> g <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> f_parent_to_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> k_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.002</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_biphasic_mean</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="va">n_biphasic</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">syn_biphasic_parms</span><span class="op">[</span><span class="va">i</span>, <span class="op">]</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"> <span class="op">}</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456L</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ds_biphasic</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_biphasic_mean</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span> +<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="va">err_1</span><span class="op">$</span><span class="va">const</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="va">err_1</span><span class="op">$</span><span class="va">prop</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span> +<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span>, secondary <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="va">ds_biphasic</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_mixed</span> <span class="op"><-</span> <span class="fu">mixed</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Kinetic model fitted by nonlinear regression to each dataset</span> +<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> +<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_m1 * m1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 271 observations of 2 variable(s) grouped in 8 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> +<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> dataset</span> +<span class="r-out co"><span class="r-pr">#></span> model 1 2 3 4 5 6 7 8 </span> +<span class="r-out co"><span class="r-pr">#></span> DFOP-SFO OK OK OK OK OK OK OK OK</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean fitted parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 </span> +<span class="r-out co"><span class="r-pr">#></span> 100.674757 -8.761916 -0.004347 -3.348812 -3.986853 </span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> -0.087392 </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mixed-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkin_long_to_wide.html b/docs/reference/mkin_long_to_wide.html index c82da5dd..be37f095 100644 --- a/docs/reference/mkin_long_to_wide.html +++ b/docs/reference/mkin_long_to_wide.html @@ -1,69 +1,14 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Convert a dataframe from long to wide format — mkin_long_to_wide • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" 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http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Convert a dataframe from long to wide format — mkin_long_to_wide • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script 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variables as columns."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ variable and several dependent variables as columns." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ variable and several dependent variables as columns." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ variable and several dependent variables as columns." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,34 +60,27 @@ variable and several dependent variables as columns." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Convert a dataframe from long to wide format</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkin_long_to_wide.R'><code>R/mkin_long_to_wide.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkin_long_to_wide.R" class="external-link"><code>R/mkin_long_to_wide.R</code></a></small> <div class="hidden name"><code>mkin_long_to_wide.Rd</code></div> </div> @@ -151,87 +90,82 @@ observed value, and converts it into a dataframe with one independent variable and several dependent variables as columns.</p> </div> - <pre class="usage"><span class='fu'>mkin_long_to_wide</span><span class='op'>(</span><span class='va'>long_data</span>, time <span class='op'>=</span> <span class='st'>"time"</span>, outtime <span class='op'>=</span> <span class='st'>"time"</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkin_long_to_wide</span><span class="op">(</span><span class="va">long_data</span>, time <span class="op">=</span> <span class="st">"time"</span>, outtime <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>long_data</th> - <td><p>The dataframe must contain one variable called "time" with + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>long_data</dt> +<dd><p>The dataframe must contain one variable called "time" with the time values specified by the <code>time</code> argument, one column called "name" with the grouping of the observed values, and finally one column of -observed values called "value".</p></td> - </tr> - <tr> - <th>time</th> - <td><p>The name of the time variable in the long input data.</p></td> - </tr> - <tr> - <th>outtime</th> - <td><p>The name of the time variable in the wide output data.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +observed values called "value".</p></dd> +<dt>time</dt> +<dd><p>The name of the time variable in the long input data.</p></dd> +<dt>outtime</dt> +<dd><p>The name of the time variable in the wide output data.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Dataframe in wide format.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='fu'>mkin_long_to_wide</span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span><span class='op'>)</span> -</div><div class='output co'>#> time parent m1 -#> 1 0 99.46 0.00 -#> 2 0 102.04 0.00 -#> 3 1 93.50 4.84 -#> 4 1 92.50 5.64 -#> 5 3 63.23 12.91 -#> 6 3 68.99 12.96 -#> 7 7 52.32 22.97 -#> 8 7 55.13 24.47 -#> 9 14 27.27 41.69 -#> 10 14 26.64 33.21 -#> 11 21 11.50 44.37 -#> 12 21 11.64 46.44 -#> 13 35 2.85 41.22 -#> 14 35 2.91 37.95 -#> 15 50 0.69 41.19 -#> 16 50 0.63 40.01 -#> 17 75 0.05 40.09 -#> 18 75 0.06 33.85 -#> 19 100 NA 31.04 -#> 20 100 NA 33.13 -#> 21 120 NA 25.15 -#> 22 120 NA 33.31</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="fu">mkin_long_to_wide</span><span class="op">(</span><span class="va">FOCUS_2006_D</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time parent m1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 99.46 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 102.04 0.00</span> +<span class="r-out co"><span class="r-pr">#></span> 3 1 93.50 4.84</span> +<span class="r-out co"><span class="r-pr">#></span> 4 1 92.50 5.64</span> +<span class="r-out co"><span class="r-pr">#></span> 5 3 63.23 12.91</span> +<span class="r-out co"><span class="r-pr">#></span> 6 3 68.99 12.96</span> +<span class="r-out co"><span class="r-pr">#></span> 7 7 52.32 22.97</span> +<span class="r-out co"><span class="r-pr">#></span> 8 7 55.13 24.47</span> +<span class="r-out co"><span class="r-pr">#></span> 9 14 27.27 41.69</span> +<span class="r-out co"><span class="r-pr">#></span> 10 14 26.64 33.21</span> +<span class="r-out co"><span class="r-pr">#></span> 11 21 11.50 44.37</span> +<span class="r-out co"><span class="r-pr">#></span> 12 21 11.64 46.44</span> +<span class="r-out co"><span class="r-pr">#></span> 13 35 2.85 41.22</span> +<span class="r-out co"><span class="r-pr">#></span> 14 35 2.91 37.95</span> +<span class="r-out co"><span class="r-pr">#></span> 15 50 0.69 41.19</span> +<span class="r-out co"><span class="r-pr">#></span> 16 50 0.63 40.01</span> +<span class="r-out co"><span class="r-pr">#></span> 17 75 0.05 40.09</span> +<span class="r-out co"><span class="r-pr">#></span> 18 75 0.06 33.85</span> +<span class="r-out co"><span class="r-pr">#></span> 19 100 NA 31.04</span> +<span class="r-out co"><span class="r-pr">#></span> 20 100 NA 33.13</span> +<span class="r-out co"><span class="r-pr">#></span> 21 120 NA 25.15</span> +<span class="r-out co"><span class="r-pr">#></span> 22 120 NA 33.31</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkin_wide_to_long.html b/docs/reference/mkin_wide_to_long.html index 15619fba..06bea7e7 100644 --- a/docs/reference/mkin_wide_to_long.html +++ b/docs/reference/mkin_wide_to_long.html @@ -1,69 +1,14 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta 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src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Convert a dataframe with observations over time into long format — mkin_wide_to_long"><meta property="og:description" content="This function simply takes a dataframe with one independent variable and several dependent variable and converts it into the long form as required by -mkinfit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +mkinfit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ mkinfit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ mkinfit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ mkinfit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,104 +60,94 @@ mkinfit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Convert a dataframe with observations over time into long format</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkin_wide_to_long.R'><code>R/mkin_wide_to_long.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkin_wide_to_long.R" class="external-link"><code>R/mkin_wide_to_long.R</code></a></small> <div class="hidden name"><code>mkin_wide_to_long.Rd</code></div> </div> <div class="ref-description"> <p>This function simply takes a dataframe with one independent variable and several dependent variable and converts it into the long form as required by -<code><a href='mkinfit.html'>mkinfit</a></code>.</p> +<code><a href="mkinfit.html">mkinfit</a></code>.</p> </div> - <pre class="usage"><span class='fu'>mkin_wide_to_long</span><span class='op'>(</span><span class='va'>wide_data</span>, time <span class='op'>=</span> <span class='st'>"t"</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkin_wide_to_long</span><span class="op">(</span><span class="va">wide_data</span>, time <span class="op">=</span> <span class="st">"t"</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>wide_data</th> - <td><p>The dataframe must contain one variable with the time + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>wide_data</dt> +<dd><p>The dataframe must contain one variable with the time values specified by the <code>time</code> argument and usually more than one -column of observed values.</p></td> - </tr> - <tr> - <th>time</th> - <td><p>The name of the time variable.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>Dataframe in long format as needed for <code><a href='mkinfit.html'>mkinfit</a></code>.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +column of observed values.</p></dd> +<dt>time</dt> +<dd><p>The name of the time variable.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>Dataframe in long format as needed for <code><a href="mkinfit.html">mkinfit</a></code>.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>wide</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span>t <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>1</span>,<span class='fl'>2</span>,<span class='fl'>3</span><span class='op'>)</span>, x <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>1</span>,<span class='fl'>4</span>,<span class='fl'>7</span><span class='op'>)</span>, y <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>3</span>,<span class='fl'>4</span>,<span class='fl'>5</span><span class='op'>)</span><span class='op'>)</span> -<span class='fu'>mkin_wide_to_long</span><span class='op'>(</span><span class='va'>wide</span><span class='op'>)</span> -</div><div class='output co'>#> name time value -#> 1 x 1 1 -#> 2 x 2 4 -#> 3 x 3 7 -#> 4 y 1 3 -#> 5 y 2 4 -#> 6 y 3 5</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">wide</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1</span>,<span class="fl">2</span>,<span class="fl">3</span><span class="op">)</span>, x <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1</span>,<span class="fl">4</span>,<span class="fl">7</span><span class="op">)</span>, y <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>,<span class="fl">4</span>,<span class="fl">5</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">mkin_wide_to_long</span><span class="op">(</span><span class="va">wide</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> name time value</span> +<span class="r-out co"><span class="r-pr">#></span> 1 x 1 1</span> +<span class="r-out co"><span class="r-pr">#></span> 2 x 2 4</span> +<span class="r-out co"><span class="r-pr">#></span> 3 x 3 7</span> +<span class="r-out co"><span class="r-pr">#></span> 4 y 1 3</span> +<span class="r-out co"><span class="r-pr">#></span> 5 y 2 4</span> +<span class="r-out co"><span class="r-pr">#></span> 6 y 3 5</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinds.html b/docs/reference/mkinds.html index fe89012c..25edbf38 100644 --- a/docs/reference/mkinds.html +++ b/docs/reference/mkinds.html @@ -1,70 +1,15 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>A dataset class for mkin — mkinds • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- 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For example, +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>A dataset class for mkin — mkinds • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="A dataset class for mkin — mkinds"><meta property="og:description" content="At the moment this dataset class is hardly used in mkin. For example, mkinfit does not take mkinds datasets as argument, but works with dataframes such as the on contained in the data field of mkinds objects. Some datasets -provided by this package come as mkinds objects nevertheless." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +provided by this package come as mkinds objects nevertheless."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ provided by this package come as mkinds objects nevertheless." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ provided by this package come as mkinds objects nevertheless." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ provided by this package come as mkinds objects nevertheless." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,34 +61,27 @@ provided by this package come as mkinds objects nevertheless." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>A dataset class for mkin</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinds.R'><code>R/mkinds.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinds.R" class="external-link"><code>R/mkinds.R</code></a></small> <div class="hidden name"><code>mkinds.Rd</code></div> </div> @@ -153,118 +92,143 @@ such as the on contained in the data field of mkinds objects. Some datasets provided by this package come as mkinds objects nevertheless.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinds</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, data <span class='op'>=</span> <span class='cn'>FALSE</span>, <span class='va'>...</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinds</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An mkinds object.</p></dd> +<dt>data</dt> +<dd><p>Should the data be printed?</p></dd> +<dt>...</dt> +<dd><p>Not used.</p></dd> +</dl></div> + <div id="public-fields"> + <h2>Public fields</h2> + <p></p><div class="r6-fields"><dl><dt><code>title</code></dt> +<dd><p>A full title for the dataset</p></dd> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An mkinds object.</p></td> - </tr> - <tr> - <th>data</th> - <td><p>Should the data be printed?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used.</p></td> - </tr> - </table> - <h2 class="hasAnchor" id="public-fields"><a class="anchor" href="#public-fields"></a>Public fields</h2> +<dt><code>sampling_times</code></dt> +<dd><p>The sampling times</p></dd> - <p><div class="r6-fields"></p><dl> -<dt><code>title</code></dt><dd><p>A full title for the dataset</p></dd> -<dt><code>sampling_times</code></dt><dd><p>The sampling times</p></dd> +<dt><code>time_unit</code></dt> +<dd><p>The time unit</p></dd> -<dt><code>time_unit</code></dt><dd><p>The time unit</p></dd> -<dt><code>observed</code></dt><dd><p>Names of the observed variables</p></dd> +<dt><code>observed</code></dt> +<dd><p>Names of the observed variables</p></dd> -<dt><code>unit</code></dt><dd><p>The unit of the observations</p></dd> -<dt><code>replicates</code></dt><dd><p>The maximum number of replicates per sampling time</p></dd> +<dt><code>unit</code></dt> +<dd><p>The unit of the observations</p></dd> -<dt><code>data</code></dt><dd><p>A data frame with at least the columns name, time + +<dt><code>replicates</code></dt> +<dd><p>The maximum number of replicates per sampling time</p></dd> + + +<dt><code>data</code></dt> +<dd><p>A data frame with at least the columns name, time and value in order to be compatible with mkinfit</p></dd> -</dl><p></div></p> - <h2 class="hasAnchor" id="methods"><a class="anchor" href="#methods"></a>Methods</h2> +</dl><p></p></div> + </div> + <div id="methods"> + <h2>Methods</h2> -<h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Public methods</h3> +<div class="section"> +<h3 id="public-methods">Public methods<a class="anchor" aria-label="anchor" href="#public-methods"></a></h3> + +<ul><li><p><a href="#method-new"><code>mkinds$new()</code></a></p></li> +<li><p><a href="#method-clone"><code>mkinds$clone()</code></a></p></li> +</ul></div><p></p><hr><a id="method-new"></a><div class="section"> +<h3 id="method-new-">Method <code>new()</code><a class="anchor" aria-label="anchor" href="#method-new-"></a></h3> +<p>Create a new mkinds object</p><div class="section"> +<h4 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a></h4> +<p></p><div class="r"><div class="sourceCode"><pre><code><span class="va"><a href="../reference/mkinds.html">mkinds</a></span><span class="op">$</span><span class="fu">new</span><span class="op">(</span>title <span class="op">=</span> <span class="st">""</span>, <span class="va">data</span>, time_unit <span class="op">=</span> <span class="cn">NA</span>, unit <span class="op">=</span> <span class="cn">NA</span><span class="op">)</span></code></pre></div><p></p></div> +</div> + +<div class="section"> +<h4 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h4> +<p></p><div class="arguments"><dl><dt><code>title</code></dt> +<dd><p>The dataset title</p></dd> -<ul> -<li><p><a href='#method-new'><code>mkinds$new()</code></a></p></li> -<li><p><a href='#method-clone'><code>mkinds$clone()</code></a></p></li> -</ul> -<p><hr> -<a id="method-new"></a></p><h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Method <code>new()</code></h3> -<p>Create a new mkinds object</p><h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Usage</h4> -<p><div class="r"></p><pre><span class='va'>mkinds</span><span class='op'>$</span><span class='fu'>new</span><span class='op'>(</span>title <span class='op'>=</span> <span class='st'>""</span>, <span class='va'>data</span>, time_unit <span class='op'>=</span> <span class='cn'>NA</span>, unit <span class='op'>=</span> <span class='cn'>NA</span><span class='op'>)</span></pre><p></div></p> -<h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Arguments</h4> -<p><div class="arguments"></p><dl> -<dt><code>title</code></dt><dd><p>The dataset title</p></dd> +<dt><code>data</code></dt> +<dd><p>The data</p></dd> -<dt><code>data</code></dt><dd><p>The data</p></dd> -<dt><code>time_unit</code></dt><dd><p>The time unit</p></dd> +<dt><code>time_unit</code></dt> +<dd><p>The time unit</p></dd> -<dt><code>unit</code></dt><dd><p>The unit of the observations</p></dd> -</dl><p></div></p> -<p><hr> -<a id="method-clone"></a></p><h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Method <code>clone()</code></h3> -<p>The objects of this class are cloneable with this method.</p><h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Usage</h4> -<p><div class="r"></p><pre><span class='va'>mkinds</span><span class='op'>$</span><span class='fu'>clone</span><span class='op'>(</span>deep <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span></pre><p></div></p> +<dt><code>unit</code></dt> +<dd><p>The unit of the observations</p></dd> -<h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Arguments</h4> -<p><div class="arguments"></p><dl> -<dt><code>deep</code></dt><dd><p>Whether to make a deep clone.</p></dd> -</dl><p></div></p> +</dl><p></p></div> +</div> + +</div><p></p><hr><a id="method-clone"></a><div class="section"> +<h3 id="method-clone-">Method <code>clone()</code><a class="anchor" aria-label="anchor" href="#method-clone-"></a></h3> +<p>The objects of this class are cloneable with this method.</p><div class="section"> +<h4 id="usage-1">Usage<a class="anchor" aria-label="anchor" href="#usage-1"></a></h4> +<p></p><div class="r"><div class="sourceCode"><pre><code><span class="va">mkinds</span><span class="op">$</span><span class="fu">clone</span><span class="op">(</span>deep <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div><p></p></div> +</div> + +<div class="section"> +<h4 id="arguments-1">Arguments<a class="anchor" aria-label="anchor" href="#arguments-1"></a></h4> +<p></p><div class="arguments"><dl><dt><code>deep</code></dt> +<dd><p>Whether to make a deep clone.</p></dd> + + +</dl><p></p></div> +</div> +</div> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>mds</span> <span class='op'><-</span> <span class='va'>mkinds</span><span class='op'>$</span><span class='fu'>new</span><span class='op'>(</span><span class='st'>"FOCUS A"</span>, <span class='va'>FOCUS_2006_A</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>mds</span><span class='op'>)</span> -</div><div class='output co'>#> <mkinds> with $title: FOCUS A -#> Observed compounds $observed: parent -#> Sampling times $sampling_times: -#> 0, 3, 7, 14, 30, 62, 90, 118 -#> With a maximum of 1 replicates</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">mds</span> <span class="op"><-</span> <span class="va">mkinds</span><span class="op">$</span><span class="fu">new</span><span class="op">(</span><span class="st">"FOCUS A"</span>, <span class="va">FOCUS_2006_A</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mds</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: FOCUS A </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 62, 90, 118 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 1 replicates</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - 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Time normalisation factors are initialised with a value of 1 for each -dataset if no data are supplied." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +dataset if no data are supplied."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ dataset if no data are supplied." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ dataset if no data are supplied." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ dataset if no data are supplied." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,34 +61,27 @@ dataset if no data are supplied." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>A class for dataset groups for mkin</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinds.R'><code>R/mkinds.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinds.R" class="external-link"><code>R/mkinds.R</code></a></small> <div class="hidden name"><code>mkindsg.Rd</code></div> </div> @@ -153,308 +92,329 @@ so that combined evaluations are desirable.</p> dataset if no data are supplied.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkindsg</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, data <span class='op'>=</span> <span class='cn'>FALSE</span>, verbose <span class='op'>=</span> <span class='va'>data</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An mkindsg object.</p></td> - </tr> - <tr> - <th>data</th> - <td><p>Should the mkinds objects be printed with their data?</p></td> - </tr> - <tr> - <th>verbose</th> - <td><p>Should the mkinds objects be printed?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="public-fields"><a class="anchor" href="#public-fields"></a>Public fields</h2> - - <p><div class="r6-fields"></p><dl> -<dt><code>title</code></dt><dd><p>A title for the dataset group</p></dd> - -<dt><code>ds</code></dt><dd><p>A list of mkinds objects</p></dd> - -<dt><code>observed_n</code></dt><dd><p>Occurrence counts of compounds in datasets</p></dd> - -<dt><code>f_time_norm</code></dt><dd><p>Time normalisation factors</p></dd> - -<dt><code>meta</code></dt><dd><p>A data frame with a row for each dataset, + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkindsg</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, verbose <span class="op">=</span> <span class="va">data</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An mkindsg object.</p></dd> +<dt>data</dt> +<dd><p>Should the mkinds objects be printed with their data?</p></dd> +<dt>verbose</dt> +<dd><p>Should the mkinds objects be printed?</p></dd> +<dt>...</dt> +<dd><p>Not used.</p></dd> +</dl></div> + <div id="public-fields"> + <h2>Public fields</h2> + <p></p><div class="r6-fields"><dl><dt><code>title</code></dt> +<dd><p>A title for the dataset group</p></dd> + + +<dt><code>ds</code></dt> +<dd><p>A list of mkinds objects</p></dd> + + +<dt><code>observed_n</code></dt> +<dd><p>Occurrence counts of compounds in datasets</p></dd> + + +<dt><code>f_time_norm</code></dt> +<dd><p>Time normalisation factors</p></dd> + + +<dt><code>meta</code></dt> +<dd><p>A data frame with a row for each dataset, containing additional information in the form of categorical data (factors) or numerical data (e.g. temperature, moisture, or covariates like soil pH).</p></dd> -</dl><p></div></p> - <h2 class="hasAnchor" id="methods"><a class="anchor" href="#methods"></a>Methods</h2> +</dl><p></p></div> + </div> + <div id="methods"> + <h2>Methods</h2> -<h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Public methods</h3> - -<ul> -<li><p><a href='#method-new'><code>mkindsg$new()</code></a></p></li> -<li><p><a href='#method-clone'><code>mkindsg$clone()</code></a></p></li> -</ul> -<p><hr> -<a id="method-new"></a></p><h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Method <code>new()</code></h3> -<p>Create a new mkindsg object</p><h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Usage</h4> -<p><div class="r"></p><pre><span class='va'>mkindsg</span><span class='op'>$</span><span class='fu'>new</span><span class='op'>(</span>title <span class='op'>=</span> <span class='st'>""</span>, <span class='va'>ds</span>, f_time_norm <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/rep.html'>rep</a></span><span class='op'>(</span><span class='fl'>1</span>, <span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span><span class='op'>)</span>, <span class='va'>meta</span><span class='op'>)</span></pre><p></div></p> - -<h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Arguments</h4> -<p><div class="arguments"></p><dl> -<dt><code>title</code></dt><dd><p>The title</p></dd> - -<dt><code>ds</code></dt><dd><p>A list of mkinds objects</p></dd> - -<dt><code>f_time_norm</code></dt><dd><p>Time normalisation factors</p></dd> - -<dt><code>meta</code></dt><dd><p>The meta data</p></dd> - -</dl><p></div></p> -<p><hr> -<a id="method-clone"></a></p><h3 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Method <code>clone()</code></h3> -<p>The objects of this class are cloneable with this method.</p><h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Usage</h4> -<p><div class="r"></p><pre><span class='va'>mkindsg</span><span class='op'>$</span><span class='fu'>clone</span><span class='op'>(</span>deep <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span></pre><p></div></p> - -<h4 class='hasAnchor' id='arguments'><a class='anchor' href='#arguments'></a>Arguments</h4> -<p><div class="arguments"></p><dl> -<dt><code>deep</code></dt><dd><p>Whether to make a deep clone.</p></dd> - -</dl><p></div></p> - - - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>mdsg</span> <span class='op'><-</span> <span class='va'>mkindsg</span><span class='op'>$</span><span class='fu'>new</span><span class='op'>(</span><span class='st'>"Experimental X"</span>, <span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>]</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>mdsg</span><span class='op'>)</span> -</div><div class='output co'>#> <mkindsg> holding 5 mkinds objects -#> Title $title: Experimental X -#> Occurrence of observed compounds $observed_n: -#> parent A1 -#> 5 5 </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>mdsg</span>, verbose <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <mkindsg> holding 5 mkinds objects -#> Title $title: Experimental X -#> Occurrence of observed compounds $observed_n: -#> parent A1 -#> 5 5 -#> -#> Datasets $ds: -#> <mkinds> with $title: Soil 6 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> -#> <mkinds> with $title: Soil 7 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 3, 7, 14, 30, 60, 90, 120, 180 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> -#> <mkinds> with $title: Soil 8 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 1, 3, 8, 14, 27, 48, 70 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> -#> <mkinds> with $title: Soil 9 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> -#> <mkinds> with $title: Soil 10 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 8, 14, 21, 41, 63, 91, 120 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>mdsg</span>, verbose <span class='op'>=</span> <span class='cn'>TRUE</span>, data <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <mkindsg> holding 5 mkinds objects -#> Title $title: Experimental X -#> Occurrence of observed compounds $observed_n: -#> parent A1 -#> 5 5 -#> -#> Datasets $ds: -#> <mkinds> with $title: Soil 6 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> time parent A1 -#> 1 0 97.2 NA -#> 2 0 96.4 NA -#> 3 3 71.1 4.3 -#> 4 3 69.2 4.6 -#> 5 6 58.1 7.0 -#> 6 6 56.6 7.2 -#> 7 10 44.4 8.2 -#> 8 10 43.4 8.0 -#> 9 20 33.3 11.0 -#> 10 20 29.2 13.7 -#> 11 34 17.6 11.5 -#> 12 34 18.0 12.7 -#> 13 55 10.5 14.9 -#> 14 55 9.3 14.5 -#> 15 90 4.5 12.1 -#> 16 90 4.7 12.3 -#> 17 112 3.0 9.9 -#> 18 112 3.4 10.2 -#> 19 132 2.3 8.8 -#> 20 132 2.7 7.8 -#> -#> <mkinds> with $title: Soil 7 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 3, 7, 14, 30, 60, 90, 120, 180 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> time parent A1 -#> 1 0 93.6 NA -#> 2 0 92.3 NA -#> 3 3 87.0 3.9 -#> 4 3 82.2 3.1 -#> 5 7 74.0 6.9 -#> 6 7 73.9 6.6 -#> 7 14 64.2 10.4 -#> 8 14 69.5 8.3 -#> 9 30 54.0 14.4 -#> 10 30 54.6 13.7 -#> 11 60 41.1 22.1 -#> 12 60 38.4 22.3 -#> 13 90 32.5 27.5 -#> 14 90 35.5 25.4 -#> 15 120 28.1 28.0 -#> 16 120 29.0 26.6 -#> 17 180 26.5 25.8 -#> 18 180 27.6 25.3 -#> -#> <mkinds> with $title: Soil 8 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 1, 3, 8, 14, 27, 48, 70 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> time parent A1 -#> 1 0 91.9 NA -#> 2 0 90.8 NA -#> 3 1 64.9 9.6 -#> 4 1 66.2 7.7 -#> 5 3 43.5 15.0 -#> 6 3 44.1 15.1 -#> 7 8 18.3 21.2 -#> 8 8 18.1 21.1 -#> 9 14 10.2 19.7 -#> 10 14 10.8 18.9 -#> 11 27 4.9 17.5 -#> 12 27 3.3 15.9 -#> 13 48 1.6 9.5 -#> 14 48 1.5 9.8 -#> 15 70 1.1 6.2 -#> 16 70 0.9 6.1 -#> -#> <mkinds> with $title: Soil 9 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> time parent A1 -#> 1 0 99.8 NA -#> 2 0 98.3 NA -#> 3 1 77.1 4.2 -#> 4 1 77.2 3.9 -#> 5 3 59.0 7.4 -#> 6 3 58.1 7.9 -#> 7 8 27.4 14.5 -#> 8 8 29.2 13.7 -#> 9 14 19.1 14.2 -#> 10 14 29.6 12.2 -#> 11 27 10.1 13.7 -#> 12 27 18.2 13.2 -#> 13 48 4.5 13.6 -#> 14 48 9.1 15.4 -#> 15 70 2.3 10.4 -#> 16 70 2.9 11.6 -#> 17 91 2.0 10.0 -#> 18 91 1.8 9.5 -#> 19 120 2.0 9.1 -#> 20 120 2.2 9.0 -#> -#> <mkinds> with $title: Soil 10 -#> Observed compounds $observed: parent, A1 -#> Sampling times $sampling_times: -#> 0, 8, 14, 21, 41, 63, 91, 120 -#> With a maximum of 2 replicates -#> Time unit: days -#> Observation unit: \%AR -#> time parent A1 -#> 1 0 96.1 NA -#> 2 0 94.3 NA -#> 3 8 73.9 3.3 -#> 4 8 73.9 3.4 -#> 5 14 69.4 3.9 -#> 6 14 73.1 2.9 -#> 7 21 65.6 6.4 -#> 8 21 65.3 7.2 -#> 9 41 55.9 9.1 -#> 10 41 54.4 8.5 -#> 11 63 47.0 11.7 -#> 12 63 49.3 12.0 -#> 13 91 44.7 13.3 -#> 14 91 46.7 13.2 -#> 15 120 42.1 14.3 -#> 16 120 41.3 12.1</div><div class='input'> -</div></pre> +<div class="section"> +<h3 id="public-methods">Public methods<a class="anchor" aria-label="anchor" href="#public-methods"></a></h3> + +<ul><li><p><a href="#method-new"><code>mkindsg$new()</code></a></p></li> +<li><p><a href="#method-clone"><code>mkindsg$clone()</code></a></p></li> +</ul></div><p></p><hr><a id="method-new"></a><div class="section"> +<h3 id="method-new-">Method <code>new()</code><a class="anchor" aria-label="anchor" href="#method-new-"></a></h3> +<p>Create a new mkindsg object</p><div class="section"> +<h4 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a></h4> +<p></p><div class="r"><div class="sourceCode"><pre><code><span class="va"><a href="../reference/mkindsg.html">mkindsg</a></span><span class="op">$</span><span class="fu">new</span><span class="op">(</span>title <span class="op">=</span> <span class="st">""</span>, <span class="va">ds</span>, f_time_norm <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span><span class="op">)</span>, <span class="va">meta</span><span class="op">)</span></code></pre></div><p></p></div> +</div> + +<div class="section"> +<h4 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h4> +<p></p><div class="arguments"><dl><dt><code>title</code></dt> +<dd><p>The title</p></dd> + + +<dt><code>ds</code></dt> +<dd><p>A list of mkinds objects</p></dd> + + +<dt><code>f_time_norm</code></dt> +<dd><p>Time normalisation factors</p></dd> + + +<dt><code>meta</code></dt> +<dd><p>The meta data</p></dd> + + +</dl><p></p></div> +</div> + +</div><p></p><hr><a id="method-clone"></a><div class="section"> +<h3 id="method-clone-">Method <code>clone()</code><a class="anchor" aria-label="anchor" href="#method-clone-"></a></h3> +<p>The objects of this class are cloneable with this method.</p><div class="section"> +<h4 id="usage-1">Usage<a class="anchor" aria-label="anchor" href="#usage-1"></a></h4> +<p></p><div class="r"><div class="sourceCode"><pre><code><span class="va">mkindsg</span><span class="op">$</span><span class="fu">clone</span><span class="op">(</span>deep <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></code></pre></div><p></p></div> +</div> + +<div class="section"> +<h4 id="arguments-1">Arguments<a class="anchor" aria-label="anchor" href="#arguments-1"></a></h4> +<p></p><div class="arguments"><dl><dt><code>deep</code></dt> +<dd><p>Whether to make a deep clone.</p></dd> + + +</dl><p></p></div> +</div> + +</div> + + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">mdsg</span> <span class="op"><-</span> <span class="va">mkindsg</span><span class="op">$</span><span class="fu">new</span><span class="op">(</span><span class="st">"Experimental X"</span>, <span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> +<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> +<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> +<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> +<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> +<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> +<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Datasets $ds:</span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 6 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 7 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 60, 90, 120, 180 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 8 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 9 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 10 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 8, 14, 21, 41, 63, 91, 120 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> +<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> +<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> +<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Datasets $ds:</span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 6 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 97.2 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 96.4 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 71.1 4.3</span> +<span class="r-out co"><span class="r-pr">#></span> 4 3 69.2 4.6</span> +<span class="r-out co"><span class="r-pr">#></span> 5 6 58.1 7.0</span> +<span class="r-out co"><span class="r-pr">#></span> 6 6 56.6 7.2</span> +<span class="r-out co"><span class="r-pr">#></span> 7 10 44.4 8.2</span> +<span class="r-out co"><span class="r-pr">#></span> 8 10 43.4 8.0</span> +<span class="r-out co"><span class="r-pr">#></span> 9 20 33.3 11.0</span> +<span class="r-out co"><span class="r-pr">#></span> 10 20 29.2 13.7</span> +<span class="r-out co"><span class="r-pr">#></span> 11 34 17.6 11.5</span> +<span class="r-out co"><span class="r-pr">#></span> 12 34 18.0 12.7</span> +<span class="r-out co"><span class="r-pr">#></span> 13 55 10.5 14.9</span> +<span class="r-out co"><span class="r-pr">#></span> 14 55 9.3 14.5</span> +<span class="r-out co"><span class="r-pr">#></span> 15 90 4.5 12.1</span> +<span class="r-out co"><span class="r-pr">#></span> 16 90 4.7 12.3</span> +<span class="r-out co"><span class="r-pr">#></span> 17 112 3.0 9.9</span> +<span class="r-out co"><span class="r-pr">#></span> 18 112 3.4 10.2</span> +<span class="r-out co"><span class="r-pr">#></span> 19 132 2.3 8.8</span> +<span class="r-out co"><span class="r-pr">#></span> 20 132 2.7 7.8</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 7 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 60, 90, 120, 180 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 93.6 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 92.3 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 87.0 3.9</span> +<span class="r-out co"><span class="r-pr">#></span> 4 3 82.2 3.1</span> +<span class="r-out co"><span class="r-pr">#></span> 5 7 74.0 6.9</span> +<span class="r-out co"><span class="r-pr">#></span> 6 7 73.9 6.6</span> +<span class="r-out co"><span class="r-pr">#></span> 7 14 64.2 10.4</span> +<span class="r-out co"><span class="r-pr">#></span> 8 14 69.5 8.3</span> +<span class="r-out co"><span class="r-pr">#></span> 9 30 54.0 14.4</span> +<span class="r-out co"><span class="r-pr">#></span> 10 30 54.6 13.7</span> +<span class="r-out co"><span class="r-pr">#></span> 11 60 41.1 22.1</span> +<span class="r-out co"><span class="r-pr">#></span> 12 60 38.4 22.3</span> +<span class="r-out co"><span class="r-pr">#></span> 13 90 32.5 27.5</span> +<span class="r-out co"><span class="r-pr">#></span> 14 90 35.5 25.4</span> +<span class="r-out co"><span class="r-pr">#></span> 15 120 28.1 28.0</span> +<span class="r-out co"><span class="r-pr">#></span> 16 120 29.0 26.6</span> +<span class="r-out co"><span class="r-pr">#></span> 17 180 26.5 25.8</span> +<span class="r-out co"><span class="r-pr">#></span> 18 180 27.6 25.3</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 8 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 91.9 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 90.8 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 3 1 64.9 9.6</span> +<span class="r-out co"><span class="r-pr">#></span> 4 1 66.2 7.7</span> +<span class="r-out co"><span class="r-pr">#></span> 5 3 43.5 15.0</span> +<span class="r-out co"><span class="r-pr">#></span> 6 3 44.1 15.1</span> +<span class="r-out co"><span class="r-pr">#></span> 7 8 18.3 21.2</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 18.1 21.1</span> +<span class="r-out co"><span class="r-pr">#></span> 9 14 10.2 19.7</span> +<span class="r-out co"><span class="r-pr">#></span> 10 14 10.8 18.9</span> +<span class="r-out co"><span class="r-pr">#></span> 11 27 4.9 17.5</span> +<span class="r-out co"><span class="r-pr">#></span> 12 27 3.3 15.9</span> +<span class="r-out co"><span class="r-pr">#></span> 13 48 1.6 9.5</span> +<span class="r-out co"><span class="r-pr">#></span> 14 48 1.5 9.8</span> +<span class="r-out co"><span class="r-pr">#></span> 15 70 1.1 6.2</span> +<span class="r-out co"><span class="r-pr">#></span> 16 70 0.9 6.1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 9 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 99.8 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 98.3 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 3 1 77.1 4.2</span> +<span class="r-out co"><span class="r-pr">#></span> 4 1 77.2 3.9</span> +<span class="r-out co"><span class="r-pr">#></span> 5 3 59.0 7.4</span> +<span class="r-out co"><span class="r-pr">#></span> 6 3 58.1 7.9</span> +<span class="r-out co"><span class="r-pr">#></span> 7 8 27.4 14.5</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 29.2 13.7</span> +<span class="r-out co"><span class="r-pr">#></span> 9 14 19.1 14.2</span> +<span class="r-out co"><span class="r-pr">#></span> 10 14 29.6 12.2</span> +<span class="r-out co"><span class="r-pr">#></span> 11 27 10.1 13.7</span> +<span class="r-out co"><span class="r-pr">#></span> 12 27 18.2 13.2</span> +<span class="r-out co"><span class="r-pr">#></span> 13 48 4.5 13.6</span> +<span class="r-out co"><span class="r-pr">#></span> 14 48 9.1 15.4</span> +<span class="r-out co"><span class="r-pr">#></span> 15 70 2.3 10.4</span> +<span class="r-out co"><span class="r-pr">#></span> 16 70 2.9 11.6</span> +<span class="r-out co"><span class="r-pr">#></span> 17 91 2.0 10.0</span> +<span class="r-out co"><span class="r-pr">#></span> 18 91 1.8 9.5</span> +<span class="r-out co"><span class="r-pr">#></span> 19 120 2.0 9.1</span> +<span class="r-out co"><span class="r-pr">#></span> 20 120 2.2 9.0</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 10 </span> +<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> +<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> +<span class="r-out co"><span class="r-pr">#></span> 0, 8, 14, 21, 41, 63, 91, 120 </span> +<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> +<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> +<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> +<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> +<span class="r-out co"><span class="r-pr">#></span> 1 0 96.1 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 2 0 94.3 NA</span> +<span class="r-out co"><span class="r-pr">#></span> 3 8 73.9 3.3</span> +<span class="r-out co"><span class="r-pr">#></span> 4 8 73.9 3.4</span> +<span class="r-out co"><span class="r-pr">#></span> 5 14 69.4 3.9</span> +<span class="r-out co"><span class="r-pr">#></span> 6 14 73.1 2.9</span> +<span class="r-out co"><span class="r-pr">#></span> 7 21 65.6 6.4</span> +<span class="r-out co"><span class="r-pr">#></span> 8 21 65.3 7.2</span> +<span class="r-out co"><span class="r-pr">#></span> 9 41 55.9 9.1</span> +<span class="r-out co"><span class="r-pr">#></span> 10 41 54.4 8.5</span> +<span class="r-out co"><span class="r-pr">#></span> 11 63 47.0 11.7</span> +<span class="r-out co"><span class="r-pr">#></span> 12 63 49.3 12.0</span> +<span class="r-out co"><span class="r-pr">#></span> 13 91 44.7 13.3</span> +<span class="r-out co"><span class="r-pr">#></span> 14 91 46.7 13.2</span> +<span class="r-out co"><span class="r-pr">#></span> 15 120 42.1 14.3</span> +<span class="r-out co"><span class="r-pr">#></span> 16 120 41.3 12.1</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a 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resulting in passing +the chi-squared test as defined in the FOCUS kinetics report from 2006."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ the chi-squared test as defined in the FOCUS kinetics report from 2006." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ the chi-squared test as defined in the FOCUS kinetics report from 2006." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ the chi-squared test as defined in the FOCUS kinetics report from 2006." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ the chi-squared test as defined in the FOCUS kinetics report from 2006." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Calculate the minimum error to assume in order to pass the variance test</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinerrmin.R'><code>R/mkinerrmin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinerrmin.R" class="external-link"><code>R/mkinerrmin.R</code></a></small> <div class="hidden name"><code>mkinerrmin.Rd</code></div> </div> @@ -149,89 +88,94 @@ the chi-squared test as defined in the FOCUS kinetics report from 2006." /> the chi-squared test as defined in the FOCUS kinetics report from 2006.</p> </div> - <pre class="usage"><span class='fu'>mkinerrmin</span><span class='op'>(</span><span class='va'>fit</span>, alpha <span class='op'>=</span> <span class='fl'>0.05</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>fit</th> - <td><p>an object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>The confidence level chosen for the chi-squared test.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit</span>, alpha <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>fit</dt> +<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>alpha</dt> +<dd><p>The confidence level chosen for the chi-squared test.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A dataframe with the following components:</p> -<dt>err.min</dt><dd><p>The -relative error, expressed as a fraction.</p></dd> <dt>n.optim</dt><dd><p>The number of -optimised parameters attributed to the data series.</p></dd> <dt>df</dt><dd><p>The number of +<dl><dt>err.min</dt> +<dd><p>The +relative error, expressed as a fraction.</p></dd> +<dt>n.optim</dt> +<dd><p>The number of +optimised parameters attributed to the data series.</p></dd> +<dt>df</dt> +<dd><p>The number of remaining degrees of freedom for the chi2 error level calculations. Note that mean values are used for the chi2 statistic and therefore every time -point with observed values in the series only counts one time.</p></dd> The +point with observed values in the series only counts one time.</p></dd> +</dl><p>The dataframe has one row for the total dataset and one further row for each -observed state variable in the model. - - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - - <p>This function is used internally by <code><a href='summary.mkinfit.html'>summary.mkinfit</a></code>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence +observed state variable in the model.</p> + </div> + <div id="details"> + <h2>Details</h2> + <p>This function is used internally by <code><a href="summary.mkinfit.html">summary.mkinfit</a></code>.</p> + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU -Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC +Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>SFO_SFO</span> <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>fit_FOCUS_D</span> <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/Round.html'>round</a></span><span class='op'>(</span><span class='fu'>mkinerrmin</span><span class='op'>(</span><span class='va'>fit_FOCUS_D</span><span class='op'>)</span>, <span class='fl'>4</span><span class='op'>)</span> -</div><div class='output co'>#> err.min n.optim df -#> All data 0.0640 4 15 -#> parent 0.0646 2 7 -#> m1 0.0469 2 8</div><div class='input'><span class='co'># \dontrun{</span> - <span class='va'>fit_FOCUS_E</span> <span class='op'>=</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_E</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/Round.html'>round</a></span><span class='op'>(</span><span class='fu'>mkinerrmin</span><span class='op'>(</span><span class='va'>fit_FOCUS_E</span><span class='op'>)</span>, <span class='fl'>4</span><span class='op'>)</span> -</div><div class='output co'>#> err.min n.optim df -#> All data 0.1544 4 13 -#> parent 0.1659 2 7 -#> m1 0.1095 2 6</div><div class='input'><span class='co'># }</span> - -</div></pre> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">fit_FOCUS_D</span> <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit_FOCUS_D</span><span class="op">)</span>, <span class="fl">4</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 0.0640 4 15</span> +<span class="r-out co"><span class="r-pr">#></span> parent 0.0646 2 7</span> +<span class="r-out co"><span class="r-pr">#></span> m1 0.0469 2 8</span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit_FOCUS_E</span> <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_E</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit_FOCUS_E</span><span class="op">)</span>, <span class="fl">4</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 0.1544 4 13</span> +<span class="r-out co"><span class="r-pr">#></span> parent 0.1659 2 7</span> +<span class="r-out co"><span class="r-pr">#></span> m1 0.1095 2 6</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinerrplot-1.png b/docs/reference/mkinerrplot-1.png Binary files differindex bae6071d..49bb1c0e 100644 --- a/docs/reference/mkinerrplot-1.png +++ b/docs/reference/mkinerrplot-1.png diff --git a/docs/reference/mkinerrplot.html b/docs/reference/mkinerrplot.html index 361ce79a..5dc188fe 100644 --- a/docs/reference/mkinerrplot.html +++ b/docs/reference/mkinerrplot.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Function to plot squared residuals and the error model for an mkin object — mkinerrplot • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - 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In addition, one or more dashed line(s) show the fitted error model. A combined plot of the fitted model and this error model plot can be obtained with plot.mkinfit -using the argument show_errplot = TRUE." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +using the argument show_errplot = TRUE."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ using the argument show_errplot = TRUE." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ using the argument show_errplot = TRUE." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ using the argument show_errplot = TRUE." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,34 +62,27 @@ using the argument show_errplot = TRUE." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to plot squared residuals and the error model for an mkin object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinerrplot.R'><code>R/mkinerrplot.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinerrplot.R" class="external-link"><code>R/mkinerrplot.R</code></a></small> <div class="hidden name"><code>mkinerrplot.Rd</code></div> </div> @@ -151,128 +90,107 @@ using the argument show_errplot = TRUE." /> <p>This function plots the squared residuals for the specified subset of the observed variables from an mkinfit object. In addition, one or more dashed line(s) show the fitted error model. A combined plot of the fitted model -and this error model plot can be obtained with <code><a href='plot.mkinfit.html'>plot.mkinfit</a></code> +and this error model plot can be obtained with <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> using the argument <code>show_errplot = TRUE</code>.</p> </div> - <pre class="usage"><span class='fu'>mkinerrplot</span><span class='op'>(</span> - <span class='va'>object</span>, - obs_vars <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>object</span><span class='op'>$</span><span class='va'>mkinmod</span><span class='op'>$</span><span class='va'>map</span><span class='op'>)</span>, - xlim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1.1</span> <span class='op'>*</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='va'>object</span><span class='op'>$</span><span class='va'>data</span><span class='op'>$</span><span class='va'>predicted</span><span class='op'>)</span><span class='op'>)</span>, - xlab <span class='op'>=</span> <span class='st'>"Predicted"</span>, - ylab <span class='op'>=</span> <span class='st'>"Squared residual"</span>, - maxy <span class='op'>=</span> <span class='st'>"auto"</span>, - legend <span class='op'>=</span> <span class='cn'>TRUE</span>, - lpos <span class='op'>=</span> <span class='st'>"topright"</span>, - col_obs <span class='op'>=</span> <span class='st'>"auto"</span>, - pch_obs <span class='op'>=</span> <span class='st'>"auto"</span>, - frame <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinerrplot</span><span class="op">(</span> + <span class="va">object</span>, + obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>, + xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">predicted</span><span class="op">)</span><span class="op">)</span>, + xlab <span class="op">=</span> <span class="st">"Predicted"</span>, + ylab <span class="op">=</span> <span class="st">"Squared residual"</span>, + maxy <span class="op">=</span> <span class="st">"auto"</span>, + legend <span class="op">=</span> <span class="cn">TRUE</span>, + lpos <span class="op">=</span> <span class="st">"topright"</span>, + col_obs <span class="op">=</span> <span class="st">"auto"</span>, + pch_obs <span class="op">=</span> <span class="st">"auto"</span>, + frame <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A fit represented in an <code><a href='mkinfit.html'>mkinfit</a></code> object.</p></td> - </tr> - <tr> - <th>obs_vars</th> - <td><p>A character vector of names of the observed variables for + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> +<dt>obs_vars</dt> +<dd><p>A character vector of names of the observed variables for which residuals should be plotted. Defaults to all observed variables in -the model</p></td> - </tr> - <tr> - <th>xlim</th> - <td><p>plot range in x direction.</p></td> - </tr> - <tr> - <th>xlab</th> - <td><p>Label for the x axis.</p></td> - </tr> - <tr> - <th>ylab</th> - <td><p>Label for the y axis.</p></td> - </tr> - <tr> - <th>maxy</th> - <td><p>Maximum value of the residuals. This is used for the scaling of -the y axis and defaults to "auto".</p></td> - </tr> - <tr> - <th>legend</th> - <td><p>Should a legend be plotted?</p></td> - </tr> - <tr> - <th>lpos</th> - <td><p>Where should the legend be placed? Default is "topright". Will -be passed on to <code><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></code>.</p></td> - </tr> - <tr> - <th>col_obs</th> - <td><p>Colors for the observed variables.</p></td> - </tr> - <tr> - <th>pch_obs</th> - <td><p>Symbols to be used for the observed variables.</p></td> - </tr> - <tr> - <th>frame</th> - <td><p>Should a frame be drawn around the plots?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>further arguments passed to <code><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +the model</p></dd> +<dt>xlim</dt> +<dd><p>plot range in x direction.</p></dd> +<dt>xlab</dt> +<dd><p>Label for the x axis.</p></dd> +<dt>ylab</dt> +<dd><p>Label for the y axis.</p></dd> +<dt>maxy</dt> +<dd><p>Maximum value of the residuals. This is used for the scaling of +the y axis and defaults to "auto".</p></dd> +<dt>legend</dt> +<dd><p>Should a legend be plotted?</p></dd> +<dt>lpos</dt> +<dd><p>Where should the legend be placed? Default is "topright". Will +be passed on to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code>.</p></dd> +<dt>col_obs</dt> +<dd><p>Colors for the observed variables.</p></dd> +<dt>pch_obs</dt> +<dd><p>Symbols to be used for the observed variables.</p></dd> +<dt>frame</dt> +<dd><p>Should a frame be drawn around the plots?</p></dd> +<dt>...</dt> +<dd><p>further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Nothing is returned by this function, as it is called for its side effect, namely to produce a plot.</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><code><a href='mkinplot.html'>mkinplot</a></code>, for a way to plot the data and the fitted + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><code><a href="mkinplot.html">mkinplot</a></code>, for a way to plot the data and the fitted lines of the mkinfit object.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># \dontrun{</span> -<span class='va'>model</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>model</span>, <span class='va'>FOCUS_2006_D</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'>mkinerrplot</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='mkinerrplot-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">FOCUS_2006_D</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">mkinerrplot</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mkinerrplot-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinfit-1.png b/docs/reference/mkinfit-1.png Binary files differindex e1d0f2f4..7c51deb6 100644 --- a/docs/reference/mkinfit-1.png +++ b/docs/reference/mkinfit-1.png diff --git a/docs/reference/mkinfit.html b/docs/reference/mkinfit.html index 2c162e49..a0644947 100644 --- a/docs/reference/mkinfit.html +++ b/docs/reference/mkinfit.html @@ -1,46 +1,5 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Fit a kinetic model to data with one or more state variables — mkinfit • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - 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-<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Fit a kinetic model to data with one or more state variables — mkinfit" /> -<meta property="og:description" content="This function maximises the likelihood of the observed data using the Port +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Fit a kinetic model to data with one or more state variables — mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Fit a kinetic model to data with one or more state variables — mkinfit"><meta property="og:description" content="This function maximises the likelihood of the observed data using the Port algorithm stats::nlminb(), and the specified initial or fixed parameters and starting values. In each step of the optimisation, the kinetic model is solved using the function mkinpredict(), except @@ -48,28 +7,14 @@ if an analytical solution is implemented, in which case the model is solved using the degradation function in the mkinmod object. The parameters of the selected error model are fitted simultaneously with the degradation model parameters, as both of them are arguments of the -likelihood function." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +likelihood function."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -80,13 +25,12 @@ likelihood function." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -95,8 +39,7 @@ likelihood function." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -106,6 +49,9 @@ likelihood function." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -120,91 +66,82 @@ likelihood function." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Fit a kinetic model to data with one or more state variables</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinfit.R'><code>R/mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinfit.R" class="external-link"><code>R/mkinfit.R</code></a></small> <div class="hidden name"><code>mkinfit.Rd</code></div> </div> <div class="ref-description"> <p>This function maximises the likelihood of the observed data using the Port -algorithm <code><a href='https://rdrr.io/r/stats/nlminb.html'>stats::nlminb()</a></code>, and the specified initial or fixed +algorithm <code><a href="https://rdrr.io/r/stats/nlminb.html" class="external-link">stats::nlminb()</a></code>, and the specified initial or fixed parameters and starting values. In each step of the optimisation, the -kinetic model is solved using the function <code><a href='mkinpredict.html'>mkinpredict()</a></code>, except +kinetic model is solved using the function <code><a href="mkinpredict.html">mkinpredict()</a></code>, except if an analytical solution is implemented, in which case the model is solved -using the degradation function in the <a href='mkinmod.html'>mkinmod</a> object. The +using the degradation function in the <a href="mkinmod.html">mkinmod</a> object. The parameters of the selected error model are fitted simultaneously with the degradation model parameters, as both of them are arguments of the likelihood function.</p> </div> - <pre class="usage"><span class='fu'>mkinfit</span><span class='op'>(</span> - <span class='va'>mkinmod</span>, - <span class='va'>observed</span>, - parms.ini <span class='op'>=</span> <span class='st'>"auto"</span>, - state.ini <span class='op'>=</span> <span class='st'>"auto"</span>, - err.ini <span class='op'>=</span> <span class='st'>"auto"</span>, - fixed_parms <span class='op'>=</span> <span class='cn'>NULL</span>, - fixed_initials <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>mkinmod</span><span class='op'>$</span><span class='va'>diffs</span><span class='op'>)</span><span class='op'>[</span><span class='op'>-</span><span class='fl'>1</span><span class='op'>]</span>, - from_max_mean <span class='op'>=</span> <span class='cn'>FALSE</span>, - solution_type <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"auto"</span>, <span class='st'>"analytical"</span>, <span class='st'>"eigen"</span>, <span class='st'>"deSolve"</span><span class='op'>)</span>, - method.ode <span class='op'>=</span> <span class='st'>"lsoda"</span>, - use_compiled <span class='op'>=</span> <span class='st'>"auto"</span>, - control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>eval.max <span class='op'>=</span> <span class='fl'>300</span>, iter.max <span class='op'>=</span> <span class='fl'>200</span><span class='op'>)</span>, - transform_rates <span class='op'>=</span> <span class='cn'>TRUE</span>, - transform_fractions <span class='op'>=</span> <span class='cn'>TRUE</span>, - quiet <span class='op'>=</span> <span class='cn'>FALSE</span>, - atol <span class='op'>=</span> <span class='fl'>1e-08</span>, - rtol <span class='op'>=</span> <span class='fl'>1e-10</span>, - error_model <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"const"</span>, <span class='st'>"obs"</span>, <span class='st'>"tc"</span><span class='op'>)</span>, - error_model_algorithm <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"auto"</span>, <span class='st'>"d_3"</span>, <span class='st'>"direct"</span>, <span class='st'>"twostep"</span>, <span class='st'>"threestep"</span>, - <span class='st'>"fourstep"</span>, <span class='st'>"IRLS"</span>, <span class='st'>"OLS"</span><span class='op'>)</span>, - reweight.tol <span class='op'>=</span> <span class='fl'>1e-08</span>, - reweight.max.iter <span class='op'>=</span> <span class='fl'>10</span>, - trace_parms <span class='op'>=</span> <span class='cn'>FALSE</span>, - test_residuals <span class='op'>=</span> <span class='cn'>FALSE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinfit</span><span class="op">(</span> + <span class="va">mkinmod</span>, + <span class="va">observed</span>, + parms.ini <span class="op">=</span> <span class="st">"auto"</span>, + state.ini <span class="op">=</span> <span class="st">"auto"</span>, + err.ini <span class="op">=</span> <span class="st">"auto"</span>, + fixed_parms <span class="op">=</span> <span class="cn">NULL</span>, + fixed_initials <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">diffs</span><span class="op">)</span><span class="op">[</span><span class="op">-</span><span class="fl">1</span><span class="op">]</span>, + from_max_mean <span class="op">=</span> <span class="cn">FALSE</span>, + solution_type <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"analytical"</span>, <span class="st">"eigen"</span>, <span class="st">"deSolve"</span><span class="op">)</span>, + method.ode <span class="op">=</span> <span class="st">"lsoda"</span>, + use_compiled <span class="op">=</span> <span class="st">"auto"</span>, + control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>eval.max <span class="op">=</span> <span class="fl">300</span>, iter.max <span class="op">=</span> <span class="fl">200</span><span class="op">)</span>, + transform_rates <span class="op">=</span> <span class="cn">TRUE</span>, + transform_fractions <span class="op">=</span> <span class="cn">TRUE</span>, + quiet <span class="op">=</span> <span class="cn">FALSE</span>, + atol <span class="op">=</span> <span class="fl">1e-08</span>, + rtol <span class="op">=</span> <span class="fl">1e-10</span>, + error_model <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"const"</span>, <span class="st">"obs"</span>, <span class="st">"tc"</span><span class="op">)</span>, + error_model_algorithm <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"d_3"</span>, <span class="st">"direct"</span>, <span class="st">"twostep"</span>, <span class="st">"threestep"</span>, + <span class="st">"fourstep"</span>, <span class="st">"IRLS"</span>, <span class="st">"OLS"</span><span class="op">)</span>, + reweight.tol <span class="op">=</span> <span class="fl">1e-08</span>, + reweight.max.iter <span class="op">=</span> <span class="fl">10</span>, + trace_parms <span class="op">=</span> <span class="cn">FALSE</span>, + test_residuals <span class="op">=</span> <span class="cn">FALSE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>mkinmod</th> - <td><p>A list of class <a href='mkinmod.html'>mkinmod</a>, containing the kinetic + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>mkinmod</dt> +<dd><p>A list of class <a href="mkinmod.html">mkinmod</a>, containing the kinetic model to be fitted to the data, or one of the shorthand names ("SFO", "FOMC", "DFOP", "HS", "SFORB", "IORE"). If a shorthand name is given, a parent only degradation model is generated for the variable with the -highest value in <code>observed</code>.</p></td> - </tr> - <tr> - <th>observed</th> - <td><p>A dataframe with the observed data. The first column called +highest value in <code>observed</code>.</p></dd> +<dt>observed</dt> +<dd><p>A dataframe with the observed data. The first column called "name" must contain the name of the observed variable for each data point. The second column must contain the times of observation, named "time". The third column must be named "value" and contain the observed values. @@ -212,11 +149,9 @@ Zero values in the "value" column will be removed, with a warning, in order to avoid problems with fitting the two-component error model. This is not expected to be a problem, because in general, values of zero are not observed in degradation data, because there is a lower limit of -detection.</p></td> - </tr> - <tr> - <th>parms.ini</th> - <td><p>A named vector of initial values for the parameters, +detection.</p></dd> +<dt>parms.ini</dt> +<dd><p>A named vector of initial values for the parameters, including parameters to be optimised and potentially also fixed parameters as indicated by <code>fixed_parms</code>. If set to "auto", initial values for rate constants are set to default values. Using parameter names that are @@ -225,113 +160,83 @@ not in the model gives an error.</p> needs. You can use the parameter lists "bparms.ode" from a previously fitted model, which contains the differential equation parameters from this model. This works nicely if the models are nested. An example is -given below.</p></td> - </tr> - <tr> - <th>state.ini</th> - <td><p>A named vector of initial values for the state variables of +given below.</p></dd> +<dt>state.ini</dt> +<dd><p>A named vector of initial values for the state variables of the model. In case the observed variables are represented by more than one model variable, the names will differ from the names of the observed -variables (see <code>map</code> component of <a href='mkinmod.html'>mkinmod</a>). The default +variables (see <code>map</code> component of <a href="mkinmod.html">mkinmod</a>). The default is to set the initial value of the first model variable to the mean of the time zero values for the variable with the maximum observed value, and all others to 0. If this variable has no time zero observations, its initial -value is set to 100.</p></td> - </tr> - <tr> - <th>err.ini</th> - <td><p>A named vector of initial values for the error model +value is set to 100.</p></dd> +<dt>err.ini</dt> +<dd><p>A named vector of initial values for the error model parameters to be optimised. If set to "auto", initial values are set to default values. Otherwise, inital values for all error model parameters -must be given.</p></td> - </tr> - <tr> - <th>fixed_parms</th> - <td><p>The names of parameters that should not be optimised but +must be given.</p></dd> +<dt>fixed_parms</dt> +<dd><p>The names of parameters that should not be optimised but rather kept at the values specified in <code>parms.ini</code>. Alternatively, a named numeric vector of parameters to be fixed, regardless of the values -in parms.ini.</p></td> - </tr> - <tr> - <th>fixed_initials</th> - <td><p>The names of model variables for which the initial +in parms.ini.</p></dd> +<dt>fixed_initials</dt> +<dd><p>The names of model variables for which the initial state at time 0 should be excluded from the optimisation. Defaults to all -state variables except for the first one.</p></td> - </tr> - <tr> - <th>from_max_mean</th> - <td><p>If this is set to TRUE, and the model has only one +state variables except for the first one.</p></dd> +<dt>from_max_mean</dt> +<dd><p>If this is set to TRUE, and the model has only one observed variable, then data before the time of the maximum observed value (after averaging for each sampling time) are discarded, and this time is subtracted from all remaining time values, so the time of the maximum -observed mean value is the new time zero.</p></td> - </tr> - <tr> - <th>solution_type</th> - <td><p>If set to "eigen", the solution of the system of +observed mean value is the new time zero.</p></dd> +<dt>solution_type</dt> +<dd><p>If set to "eigen", the solution of the system of differential equations is based on the spectral decomposition of the coefficient matrix in cases that this is possible. If set to "deSolve", a -numerical <a href='https://rdrr.io/pkg/deSolve/man/ode.html'>ode solver from package deSolve</a> is used. If +numerical <a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">ode solver from package deSolve</a> is used. If set to "analytical", an analytical solution of the model is used. This is only implemented for relatively simple degradation models. The default is "auto", which uses "analytical" if possible, otherwise "deSolve" if a compiler is present, and "eigen" if no compiler is present and the model -can be expressed using eigenvalues and eigenvectors.</p></td> - </tr> - <tr> - <th>method.ode</th> - <td><p>The solution method passed via <code><a href='mkinpredict.html'>mkinpredict()</a></code> -to <code><a href='https://rdrr.io/pkg/deSolve/man/ode.html'>deSolve::ode()</a></code> in case the solution type is "deSolve". The default -"lsoda" is performant, but sometimes fails to converge.</p></td> - </tr> - <tr> - <th>use_compiled</th> - <td><p>If set to <code>FALSE</code>, no compiled version of the -<a href='mkinmod.html'>mkinmod</a> model is used in the calls to <code><a href='mkinpredict.html'>mkinpredict()</a></code> even if a compiled -version is present.</p></td> - </tr> - <tr> - <th>control</th> - <td><p>A list of control arguments passed to <code><a href='https://rdrr.io/r/stats/nlminb.html'>stats::nlminb()</a></code>.</p></td> - </tr> - <tr> - <th>transform_rates</th> - <td><p>Boolean specifying if kinetic rate constants should +can be expressed using eigenvalues and eigenvectors.</p></dd> +<dt>method.ode</dt> +<dd><p>The solution method passed via <code><a href="mkinpredict.html">mkinpredict()</a></code> +to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code> in case the solution type is "deSolve". The default +"lsoda" is performant, but sometimes fails to converge.</p></dd> +<dt>use_compiled</dt> +<dd><p>If set to <code>FALSE</code>, no compiled version of the +<a href="mkinmod.html">mkinmod</a> model is used in the calls to <code><a href="mkinpredict.html">mkinpredict()</a></code> even if a compiled +version is present.</p></dd> +<dt>control</dt> +<dd><p>A list of control arguments passed to <code><a href="https://rdrr.io/r/stats/nlminb.html" class="external-link">stats::nlminb()</a></code>.</p></dd> +<dt>transform_rates</dt> +<dd><p>Boolean specifying if kinetic rate constants should be transformed in the model specification used in the fitting for better compliance with the assumption of normal distribution of the estimator. If TRUE, also alpha and beta parameters of the FOMC model are log-transformed, as well as k1 and k2 rate constants for the DFOP and HS models and the break point tb of the HS model. If FALSE, zero is used as -a lower bound for the rates in the optimisation.</p></td> - </tr> - <tr> - <th>transform_fractions</th> - <td><p>Boolean specifying if formation fractions +a lower bound for the rates in the optimisation.</p></dd> +<dt>transform_fractions</dt> +<dd><p>Boolean specifying if formation fractions should be transformed in the model specification used in the fitting for better compliance with the assumption of normal distribution of the estimator. The default (TRUE) is to do transformations. If TRUE, the g parameter of the DFOP model is also transformed. Transformations -are described in <a href='transform_odeparms.html'>transform_odeparms</a>.</p></td> - </tr> - <tr> - <th>quiet</th> - <td><p>Suppress printing out the current value of the negative -log-likelihood after each improvement?</p></td> - </tr> - <tr> - <th>atol</th> - <td><p>Absolute error tolerance, passed to <code><a href='https://rdrr.io/pkg/deSolve/man/ode.html'>deSolve::ode()</a></code>. Default -is 1e-8, which is lower than the default in the <code><a href='https://rdrr.io/pkg/deSolve/man/lsoda.html'>deSolve::lsoda()</a></code> -function which is used per default.</p></td> - </tr> - <tr> - <th>rtol</th> - <td><p>Absolute error tolerance, passed to <code><a href='https://rdrr.io/pkg/deSolve/man/ode.html'>deSolve::ode()</a></code>. Default -is 1e-10, much lower than in <code><a href='https://rdrr.io/pkg/deSolve/man/lsoda.html'>deSolve::lsoda()</a></code>.</p></td> - </tr> - <tr> - <th>error_model</th> - <td><p>If the error model is "const", a constant standard +are described in <a href="transform_odeparms.html">transform_odeparms</a>.</p></dd> +<dt>quiet</dt> +<dd><p>Suppress printing out the current value of the negative +log-likelihood after each improvement?</p></dd> +<dt>atol</dt> +<dd><p>Absolute error tolerance, passed to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>. Default +is 1e-8, which is lower than the default in the <code><a href="https://rdrr.io/pkg/deSolve/man/lsoda.html" class="external-link">deSolve::lsoda()</a></code> +function which is used per default.</p></dd> +<dt>rtol</dt> +<dd><p>Absolute error tolerance, passed to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>. Default +is 1e-10, much lower than in <code><a href="https://rdrr.io/pkg/deSolve/man/lsoda.html" class="external-link">deSolve::lsoda()</a></code>.</p></dd> +<dt>error_model</dt> +<dd><p>If the error model is "const", a constant standard deviation is assumed.</p> <p>If the error model is "obs", each observed variable is assumed to have its own variance.</p> @@ -340,11 +245,9 @@ error model similar to the one described by Rocke and Lorenzato (1995) is used for setting up the likelihood function. Note that this model deviates from the model by Rocke and Lorenzato, as their model implies that the errors follow a lognormal distribution for large values, not a -normal distribution as assumed by this method.</p></td> - </tr> - <tr> - <th>error_model_algorithm</th> - <td><p>If "auto", the selected algorithm depends on +normal distribution as assumed by this method.</p></dd> +<dt>error_model_algorithm</dt> +<dd><p>If "auto", the selected algorithm depends on the error model. If the error model is "const", unweighted nonlinear least squares fitting ("OLS") is selected. If the error model is "obs", or "tc", the "d_3" algorithm is selected.</p> @@ -367,372 +270,375 @@ degradation and error model parameters.</p> unweighted least squares, and then iterates optimization of the error model parameters and subsequent optimization of the degradation model using those error model parameters, until the error model parameters -converge.</p></td> - </tr> - <tr> - <th>reweight.tol</th> - <td><p>Tolerance for the convergence criterion calculated from -the error model parameters in IRLS fits.</p></td> - </tr> - <tr> - <th>reweight.max.iter</th> - <td><p>Maximum number of iterations in IRLS fits.</p></td> - </tr> - <tr> - <th>trace_parms</th> - <td><p>Should a trace of the parameter values be listed?</p></td> - </tr> - <tr> - <th>test_residuals</th> - <td><p>Should the residuals be tested for normal distribution?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments that will be passed on to -<code><a href='https://rdrr.io/pkg/deSolve/man/ode.html'>deSolve::ode()</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +converge.</p></dd> +<dt>reweight.tol</dt> +<dd><p>Tolerance for the convergence criterion calculated from +the error model parameters in IRLS fits.</p></dd> +<dt>reweight.max.iter</dt> +<dd><p>Maximum number of iterations in IRLS fits.</p></dd> +<dt>trace_parms</dt> +<dd><p>Should a trace of the parameter values be listed?</p></dd> +<dt>test_residuals</dt> +<dd><p>Should the residuals be tested for normal distribution?</p></dd> +<dt>...</dt> +<dd><p>Further arguments that will be passed on to +<code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A list with "mkinfit" in the class attribute.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>Per default, parameters in the kinetic models are internally transformed in order to better satisfy the assumption of a normal distribution of their estimators.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - + </div> + <div id="note"> + <h2>Note</h2> <p>When using the "IORE" submodel for metabolites, fitting with "transform_rates = TRUE" (the default) often leads to failures of the numerical ODE solver. In this situation it may help to switch off the internal rate transformation.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>Rocke DM and Lorenzato S (1995) A two-component model for measurement error in analytical chemistry. <em>Technometrics</em> 37(2), 176-184.</p> <p>Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical Degradation Data. <em>Environments</em> 6(12) 124 -doi: <a href='https://doi.org/10.3390/environments6120124'>10.3390/environments6120124</a> +doi: <a href="https://doi.org/10.3390/environments6120124" class="external-link">10.3390/environments6120124</a> .</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><a href='summary.mkinfit.html'>summary.mkinfit</a>, <a href='plot.mkinfit.html'>plot.mkinfit</a>, <a href='parms.html'>parms</a> and <a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a>.</p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><a href="summary.mkinfit.html">summary.mkinfit</a>, <a href="plot.mkinfit.html">plot.mkinfit</a>, <a href="parms.html">parms</a> and <a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a>.</p> <p>Comparisons of models fitted to the same data can be made using -<code><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></code> by virtue of the method <code><a href='logLik.mkinfit.html'>logLik.mkinfit</a></code>.</p> +<code><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></code> by virtue of the method <code><a href="logLik.mkinfit.html">logLik.mkinfit</a></code>.</p> <p>Fitting of several models to several datasets in a single call to -<code><a href='mmkin.html'>mmkin</a></code>.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +<code><a href="mmkin.html">mmkin</a></code>.</p></div> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># Use shorthand notation for parent only degradation</span> -<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> mkin version used for fitting: 1.0.4 -#> R version used for fitting: 4.0.4 -#> Date of fit: Wed Mar 31 19:15:41 2021 -#> Date of summary: Wed Mar 31 19:15:41 2021 -#> -#> Equations: -#> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent -#> -#> Model predictions using solution type analytical -#> -#> Fitted using 222 model solutions performed in 0.046 s -#> -#> Error model: Constant variance -#> -#> Error model algorithm: OLS -#> -#> Starting values for parameters to be optimised: -#> value type -#> parent_0 85.1 state -#> alpha 1.0 deparm -#> beta 10.0 deparm -#> -#> Starting values for the transformed parameters actually optimised: -#> value lower upper -#> parent_0 85.100000 -Inf Inf -#> log_alpha 0.000000 -Inf Inf -#> log_beta 2.302585 -Inf Inf -#> -#> Fixed parameter values: -#> None -#> -#> Results: -#> -#> AIC BIC logLik -#> 44.68652 45.47542 -18.34326 -#> -#> Optimised, transformed parameters with symmetric confidence intervals: -#> Estimate Std. Error Lower Upper -#> parent_0 85.87000 1.8070 81.23000 90.5200 -#> log_alpha 0.05192 0.1353 -0.29580 0.3996 -#> log_beta 0.65100 0.2287 0.06315 1.2390 -#> sigma 1.85700 0.4378 0.73200 2.9830 -#> -#> Parameter correlation: -#> parent_0 log_alpha log_beta sigma -#> parent_0 1.000e+00 -1.565e-01 -3.142e-01 4.772e-08 -#> log_alpha -1.565e-01 1.000e+00 9.564e-01 1.005e-07 -#> log_beta -3.142e-01 9.564e-01 1.000e+00 8.541e-08 -#> sigma 4.772e-08 1.005e-07 8.541e-08 1.000e+00 -#> -#> Backtransformed parameters: -#> Confidence intervals for internally transformed parameters are asymmetric. -#> t-test (unrealistically) based on the assumption of normal distribution -#> for estimators of untransformed parameters. -#> Estimate t value Pr(>t) Lower Upper -#> parent_0 85.870 47.530 3.893e-08 81.2300 90.520 -#> alpha 1.053 7.393 3.562e-04 0.7439 1.491 -#> beta 1.917 4.373 3.601e-03 1.0650 3.451 -#> sigma 1.857 4.243 4.074e-03 0.7320 2.983 -#> -#> FOCUS Chi2 error levels in percent: -#> err.min n.optim df -#> All data 6.657 3 6 -#> parent 6.657 3 6 -#> -#> Estimated disappearance times: -#> DT50 DT90 DT50back -#> parent 1.785 15.15 4.56 -#> -#> Data: -#> time variable observed predicted residual -#> 0 parent 85.1 85.875 -0.7749 -#> 1 parent 57.9 55.191 2.7091 -#> 3 parent 29.9 31.845 -1.9452 -#> 7 parent 14.6 17.012 -2.4124 -#> 14 parent 9.7 9.241 0.4590 -#> 28 parent 6.6 4.754 1.8460 -#> 63 parent 4.0 2.102 1.8977 -#> 91 parent 3.9 1.441 2.4590 -#> 119 parent 0.6 1.092 -0.4919</div><div class='input'> -<span class='co'># One parent compound, one metabolite, both single first order.</span> -<span class='co'># We remove zero values from FOCUS dataset D in order to avoid warnings</span> -<span class='va'>FOCUS_D</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span> -<span class='co'># Use mkinsub for convenience in model formulation. Pathway to sink included per default.</span> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='co'># Fit the model quietly to the FOCUS example dataset D using defaults</span> -<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='mkinfit-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># As lower parent values appear to have lower variance, we try an alternative error model</span> -<span class='va'>fit.tc</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -<span class='co'># This avoids the warning, and the likelihood ratio test confirms it is preferable</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>fit.tc</span>, <span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0 -#> Model 2: SFO_SFO with error model const and fixed parameter(s) m1_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 6 -64.983 -#> 2 5 -97.224 -1 64.483 9.737e-16 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='co'># We can also allow for different variances of parent and metabolite as error model</span> -<span class='va'>fit.obs</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"obs"</span><span class='op'>)</span> -<span class='co'># The two-component error model has significantly higher likelihood</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>fit.obs</span>, <span class='va'>fit.tc</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0 -#> Model 2: SFO_SFO with error model obs and fixed parameter(s) m1_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 6 -64.983 -#> 2 6 -96.936 0 63.907 < 2.2e-16 *** -#> --- -#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</div><div class='input'><span class='fu'><a href='parms.html'>parms</a></span><span class='op'>(</span><span class='va'>fit.tc</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 k_parent k_m1 f_parent_to_m1 sigma_low -#> 1.007343e+02 1.005562e-01 5.166712e-03 5.083933e-01 3.049883e-03 -#> rsd_high -#> 7.928118e-02 </div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit.tc</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_m1 parent_sink -#> 0.5083933 0.4916067 -#> -#> $distimes -#> DT50 DT90 -#> parent 6.89313 22.89848 -#> m1 134.15634 445.65772 -#> </div><div class='input'> -<span class='co'># We can show a quick (only one replication) benchmark for this case, as we</span> -<span class='co'># have several alternative solution methods for the model. We skip</span> -<span class='co'># uncompiled deSolve, as it is so slow. More benchmarks are found in the</span> -<span class='co'># benchmark vignette</span> -<span class='co'># \dontrun{</span> -<span class='kw'>if</span><span class='op'>(</span><span class='kw'><a href='https://rdrr.io/r/base/library.html'>require</a></span><span class='op'>(</span><span class='va'><a href='http://rbenchmark.googlecode.com'>rbenchmark</a></span><span class='op'>)</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='https://rdrr.io/pkg/rbenchmark/man/benchmark.html'>benchmark</a></span><span class='op'>(</span>replications <span class='op'>=</span> <span class='fl'>1</span>, order <span class='op'>=</span> <span class='st'>"relative"</span>, columns <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"test"</span>, <span class='st'>"relative"</span>, <span class='st'>"elapsed"</span><span class='op'>)</span>, - deSolve_compiled <span class='op'>=</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, use_compiled <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - eigen <span class='op'>=</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, - solution_type <span class='op'>=</span> <span class='st'>"eigen"</span><span class='op'>)</span>, - analytical <span class='op'>=</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, - solution_type <span class='op'>=</span> <span class='st'>"analytical"</span><span class='op'>)</span><span class='op'>)</span> -<span class='op'>}</span> -</div><div class='output co'>#> <span class='message'>Loading required package: rbenchmark</span></div><div class='output co'>#> test relative elapsed -#> 3 analytical 1.000 0.547 -#> 1 deSolve_compiled 1.717 0.939 -#> 2 eigen 2.644 1.446</div><div class='input'><span class='co'># }</span> - -<span class='co'># Use stepwise fitting, using optimised parameters from parent only fit, FOMC-SFO</span> -<span class='co'># \dontrun{</span> -<span class='va'>FOMC_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>fit.FOMC_SFO</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>FOMC_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='co'># Again, we get a warning and try a more sophisticated error model</span> -<span class='va'>fit.FOMC_SFO.tc</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>FOMC_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -<span class='co'># This model has a higher likelihood, but not significantly so</span> -<span class='fu'><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></span><span class='op'>(</span><span class='va'>fit.tc</span>, <span class='va'>fit.FOMC_SFO.tc</span><span class='op'>)</span> -</div><div class='output co'>#> Likelihood ratio test -#> -#> Model 1: FOMC_SFO with error model tc and fixed parameter(s) m1_0 -#> Model 2: SFO_SFO with error model tc and fixed parameter(s) m1_0 -#> #Df LogLik Df Chisq Pr(>Chisq) -#> 1 7 -64.829 -#> 2 6 -64.983 -1 0.3075 0.5792</div><div class='input'><span class='co'># Also, the missing standard error for log_beta and the t-tests for alpha</span> -<span class='co'># and beta indicate overparameterisation</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.FOMC_SFO.tc</span>, data <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: NaNs produced</span></div><div class='output co'>#> <span class='warning'>Warning: NaNs produced</span></div><div class='output co'>#> <span class='warning'>Warning: diag(.) had 0 or NA entries; non-finite result is doubtful</span></div><div class='output co'>#> mkin version used for fitting: 1.0.4 -#> R version used for fitting: 4.0.4 -#> Date of fit: Wed Mar 31 19:15:53 2021 -#> Date of summary: Wed Mar 31 19:15:53 2021 -#> -#> Equations: -#> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent -#> d_m1/dt = + f_parent_to_m1 * (alpha/beta) * 1/((time/beta) + 1) * -#> parent - k_m1 * m1 -#> -#> Model predictions using solution type deSolve -#> -#> Fitted using 3729 model solutions performed in 2.798 s -#> -#> Error model: Two-component variance function -#> -#> Error model algorithm: d_3 -#> Direct fitting and three-step fitting yield approximately the same likelihood -#> -#> Starting values for parameters to be optimised: -#> value type -#> parent_0 100.75 state -#> alpha 1.00 deparm -#> beta 10.00 deparm -#> k_m1 0.10 deparm -#> f_parent_to_m1 0.50 deparm -#> sigma_low 0.10 error -#> rsd_high 0.10 error -#> -#> Starting values for the transformed parameters actually optimised: -#> value lower upper -#> parent_0 100.750000 -Inf Inf -#> log_k_m1 -2.302585 -Inf Inf -#> f_parent_qlogis 0.000000 -Inf Inf -#> log_alpha 0.000000 -Inf Inf -#> log_beta 2.302585 -Inf Inf -#> sigma_low 0.100000 0 Inf -#> rsd_high 0.100000 0 Inf -#> -#> Fixed parameter values: -#> value type -#> m1_0 0 state -#> -#> Results: -#> -#> AIC BIC logLik -#> 143.658 155.1211 -64.82902 -#> -#> Optimised, transformed parameters with symmetric confidence intervals: -#> Estimate Std. Error Lower Upper -#> parent_0 101.600000 2.6400000 96.240000 107.000000 -#> log_k_m1 -5.284000 0.0929100 -5.474000 -5.095000 -#> f_parent_qlogis 0.001426 0.0767000 -0.155000 0.157800 -#> log_alpha 5.522000 0.0077320 5.506000 5.538000 -#> log_beta 7.806000 NaN NaN NaN -#> sigma_low 0.002488 0.0002431 0.001992 0.002984 -#> rsd_high 0.079210 0.0093280 0.060180 0.098230 -#> -#> Parameter correlation: -#> parent_0 log_k_m1 f_parent_qlogis log_alpha log_beta -#> parent_0 1.000000 -0.095226 -0.76678 0.70544 NaN -#> log_k_m1 -0.095226 1.000000 0.51432 -0.14387 NaN -#> f_parent_qlogis -0.766780 0.514321 1.00000 -0.61396 NaN -#> log_alpha 0.705444 -0.143872 -0.61396 1.00000 NaN -#> log_beta NaN NaN NaN NaN 1 -#> sigma_low 0.016073 0.001586 0.01548 5.87007 NaN -#> rsd_high 0.006626 -0.011700 -0.05357 0.04849 NaN -#> sigma_low rsd_high -#> parent_0 0.016073 0.006626 -#> log_k_m1 0.001586 -0.011700 -#> f_parent_qlogis 0.015476 -0.053566 -#> log_alpha 5.870075 0.048487 -#> log_beta NaN NaN -#> sigma_low 1.000000 -0.652558 -#> rsd_high -0.652558 1.000000 -#> -#> Backtransformed parameters: -#> Confidence intervals for internally transformed parameters are asymmetric. -#> t-test (unrealistically) based on the assumption of normal distribution -#> for estimators of untransformed parameters. -#> Estimate t value Pr(>t) Lower Upper -#> parent_0 1.016e+02 32.7800 6.311e-26 9.624e+01 1.070e+02 -#> k_m1 5.072e-03 10.1200 1.216e-11 4.196e-03 6.130e-03 -#> f_parent_to_m1 5.004e-01 20.8300 4.317e-20 4.613e-01 5.394e-01 -#> alpha 2.502e+02 0.5624 2.889e-01 2.463e+02 2.542e+02 -#> beta 2.455e+03 0.5549 2.915e-01 NA NA -#> sigma_low 2.488e-03 0.4843 3.158e-01 1.992e-03 2.984e-03 -#> rsd_high 7.921e-02 8.4300 8.001e-10 6.018e-02 9.823e-02 -#> -#> FOCUS Chi2 error levels in percent: -#> err.min n.optim df -#> All data 6.781 5 14 -#> parent 7.141 3 6 -#> m1 4.640 2 8 -#> -#> Resulting formation fractions: -#> ff -#> parent_m1 0.5004 -#> parent_sink 0.4996 -#> -#> Estimated disappearance times: -#> DT50 DT90 DT50back -#> parent 6.812 22.7 6.834 -#> m1 136.661 454.0 NA</div><div class='input'> -<span class='co'># We can easily use starting parameters from the parent only fit (only for illustration)</span> -<span class='va'>fit.FOMC</span> <span class='op'>=</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -<span class='va'>fit.FOMC_SFO</span> <span class='op'><-</span> <span class='fu'>mkinfit</span><span class='op'>(</span><span class='va'>FOMC_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, - parms.ini <span class='op'>=</span> <span class='va'>fit.FOMC</span><span class='op'>$</span><span class='va'>bparms.ode</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -<span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># Use shorthand notation for parent only degradation</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:30:39 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:30:39 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted using 222 model solutions performed in 0.046 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 85.1 state</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 1.0 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> beta 10.0 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 85.100000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.000000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 2.302585 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 44.68652 45.47542 -18.34326</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 85.87000 1.8070 81.23000 90.5200</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.05192 0.1353 -0.29580 0.3996</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 0.65100 0.2287 0.06315 1.2390</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.85700 0.4378 0.73200 2.9830</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_alpha log_beta sigma</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 -1.565e-01 -3.142e-01 4.772e-08</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha -1.565e-01 1.000e+00 9.564e-01 1.005e-07</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta -3.142e-01 9.564e-01 1.000e+00 8.541e-08</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 4.772e-08 1.005e-07 8.541e-08 1.000e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 85.870 47.530 3.893e-08 81.2300 90.520</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 1.053 7.393 3.562e-04 0.7439 1.491</span> +<span class="r-out co"><span class="r-pr">#></span> beta 1.917 4.373 3.601e-03 1.0650 3.451</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.857 4.243 4.074e-03 0.7320 2.983</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 6.657 3 6</span> +<span class="r-out co"><span class="r-pr">#></span> parent 6.657 3 6</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> +<span class="r-out co"><span class="r-pr">#></span> parent 1.785 15.15 4.56</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> +<span class="r-out co"><span class="r-pr">#></span> 0 parent 85.1 85.875 -0.7749</span> +<span class="r-out co"><span class="r-pr">#></span> 1 parent 57.9 55.191 2.7091</span> +<span class="r-out co"><span class="r-pr">#></span> 3 parent 29.9 31.845 -1.9452</span> +<span class="r-out co"><span class="r-pr">#></span> 7 parent 14.6 17.012 -2.4124</span> +<span class="r-out co"><span class="r-pr">#></span> 14 parent 9.7 9.241 0.4590</span> +<span class="r-out co"><span class="r-pr">#></span> 28 parent 6.6 4.754 1.8460</span> +<span class="r-out co"><span class="r-pr">#></span> 63 parent 4.0 2.102 1.8977</span> +<span class="r-out co"><span class="r-pr">#></span> 91 parent 3.9 1.441 2.4590</span> +<span class="r-out co"><span class="r-pr">#></span> 119 parent 0.6 1.092 -0.4919</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># One parent compound, one metabolite, both single first order.</span></span> +<span class="r-in"><span class="co"># We remove zero values from FOCUS dataset D in order to avoid warnings</span></span> +<span class="r-in"><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Use mkinsub for convenience in model formulation. Pathway to sink included per default.</span></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Fit the model quietly to the FOCUS example dataset D using defaults</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mkinfit-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># As lower parent values appear to have lower variance, we try an alternative error model</span></span> +<span class="r-in"><span class="va">fit.tc</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># This avoids the warning, and the likelihood ratio test confirms it is preferable</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.tc</span>, <span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model const and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 6 -64.983 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 5 -97.224 -1 64.483 9.737e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="co"># We can also allow for different variances of parent and metabolite as error model</span></span> +<span class="r-in"><span class="va">fit.obs</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># The two-component error model has significantly higher likelihood</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.obs</span>, <span class="va">fit.tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model obs and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> +<span class="r-out co"><span class="r-pr">#></span> 1 6 -64.983 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 6 -96.936 0 63.907 < 2.2e-16 ***</span> +<span class="r-out co"><span class="r-pr">#></span> ---</span> +<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> +<span class="r-in"><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit.tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent k_m1 f_parent_to_m1 sigma_low </span> +<span class="r-out co"><span class="r-pr">#></span> 1.007343e+02 1.005562e-01 5.166712e-03 5.083933e-01 3.049883e-03 </span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high </span> +<span class="r-out co"><span class="r-pr">#></span> 7.928118e-02 </span> +<span class="r-in"><span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_m1 parent_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 0.5083933 0.4916067 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 6.89313 22.89848</span> +<span class="r-out co"><span class="r-pr">#></span> m1 134.15634 445.65772</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># We can show a quick (only one replication) benchmark for this case, as we</span></span> +<span class="r-in"><span class="co"># have several alternative solution methods for the model. We skip</span></span> +<span class="r-in"><span class="co"># uncompiled deSolve, as it is so slow. More benchmarks are found in the</span></span> +<span class="r-in"><span class="co"># benchmark vignette</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="kw">if</span><span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span>replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>, columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span>,</span> +<span class="r-in"> deSolve_compiled <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> eigen <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span>,</span> +<span class="r-in"> analytical <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-out co"><span class="r-pr">#></span> test relative elapsed</span> +<span class="r-out co"><span class="r-pr">#></span> 3 analytical 1.000 0.699</span> +<span class="r-out co"><span class="r-pr">#></span> 1 deSolve_compiled 1.595 1.115</span> +<span class="r-out co"><span class="r-pr">#></span> 2 eigen 2.252 1.574</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Use stepwise fitting, using optimised parameters from parent only fit, FOMC-SFO</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fit.FOMC_SFO</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Again, we get a warning and try a more sophisticated error model</span></span> +<span class="r-in"><span class="va">fit.FOMC_SFO.tc</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># This model has a higher likelihood, but not significantly so</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.tc</span>, <span class="va">fit.FOMC_SFO.tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model 1: FOMC_SFO with error model tc and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> +<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> +<span class="r-out co"><span class="r-pr">#></span> 1 7 -64.829 </span> +<span class="r-out co"><span class="r-pr">#></span> 2 6 -64.983 -1 0.3075 0.5792</span> +<span class="r-in"><span class="co"># Also, the missing standard error for log_beta and the t-tests for alpha</span></span> +<span class="r-in"><span class="co"># and beta indicate overparameterisation</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.FOMC_SFO.tc</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:30:53 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:30:53 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * (alpha/beta) * 1/((time/beta) + 1) *</span> +<span class="r-out co"><span class="r-pr">#></span> parent - k_m1 * m1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type deSolve </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted using 3729 model solutions performed in 2.916 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model: Two-component variance function </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: d_3 </span> +<span class="r-out co"><span class="r-pr">#></span> Direct fitting and three-step fitting yield approximately the same likelihood </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 100.75 state</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 1.00 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> beta 10.00 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.10 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.50 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.10 error</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.10 error</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 100.750000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -2.302585 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.000000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 2.302585 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.100000 0 Inf</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.100000 0 Inf</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> m1_0 0 state</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 143.658 155.1211 -64.82902</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 101.600000 2.6400000 96.240000 107.000000</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -5.284000 0.0929100 -5.474000 -5.095000</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.001426 0.0767000 -0.155000 0.157800</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 5.522000 0.0077320 5.506000 5.538000</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 7.806000 NaN NaN NaN</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.002488 0.0002431 0.001992 0.002984</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.079210 0.0093280 0.060180 0.098230</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_alpha log_beta</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000000 -0.095226 -0.76678 0.70544 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -0.095226 1.000000 0.51432 -0.14387 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.766780 0.514321 1.00000 -0.61396 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.705444 -0.143872 -0.61396 1.00000 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta NaN NaN NaN NaN 1</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.016073 0.001586 0.01548 5.87007 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.006626 -0.011700 -0.05357 0.04849 NaN</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low rsd_high</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 0.016073 0.006626</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 0.001586 -0.011700</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.015476 -0.053566</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 5.870075 0.048487</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta NaN NaN</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 1.000000 -0.652558</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high -0.652558 1.000000</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.016e+02 32.7800 6.311e-26 9.624e+01 1.070e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 5.072e-03 10.1200 1.216e-11 4.196e-03 6.130e-03</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 5.004e-01 20.8300 4.317e-20 4.613e-01 5.394e-01</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 2.502e+02 0.5624 2.889e-01 2.463e+02 2.542e+02</span> +<span class="r-out co"><span class="r-pr">#></span> beta 2.455e+03 0.5549 2.915e-01 NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low 2.488e-03 0.4843 3.158e-01 1.992e-03 2.984e-03</span> +<span class="r-out co"><span class="r-pr">#></span> rsd_high 7.921e-02 8.4300 8.001e-10 6.018e-02 9.823e-02</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 6.781 5 14</span> +<span class="r-out co"><span class="r-pr">#></span> parent 7.141 3 6</span> +<span class="r-out co"><span class="r-pr">#></span> m1 4.640 2 8</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> +<span class="r-out co"><span class="r-pr">#></span> ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_m1 0.5004</span> +<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.4996</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> +<span class="r-out co"><span class="r-pr">#></span> parent 6.812 22.7 6.834</span> +<span class="r-out co"><span class="r-pr">#></span> m1 136.661 454.0 NA</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># We can easily use starting parameters from the parent only fit (only for illustration)</span></span> +<span class="r-in"><span class="va">fit.FOMC</span> <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit.FOMC_SFO</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> +<span class="r-in"> parms.ini <span class="op">=</span> <span class="va">fit.FOMC</span><span class="op">$</span><span class="va">bparms.ode</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinmod.html b/docs/reference/mkinmod.html index f9976c6b..a5cc3d7a 100644 --- a/docs/reference/mkinmod.html +++ b/docs/reference/mkinmod.html @@ -1,73 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Function to set up a kinetic model with one or more state variables — mkinmod • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script 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Print mkinmod objects in a way that the user finds his way to get to its -components. -This is a convenience function to set up the lists used as arguments for -mkinmod." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +components."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -78,13 +21,12 @@ mkinmod." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -93,8 +35,7 @@ mkinmod." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -104,6 +45,9 @@ mkinmod." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -118,34 +62,27 @@ mkinmod." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to set up a kinetic model with one or more state variables</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinmod.R'><code>R/mkinmod.R</code></a>, <a href='https://github.com/jranke/mkin/blob/master/R/mkinsub.R'><code>R/mkinsub.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinmod.R" class="external-link"><code>R/mkinmod.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinsub.R" class="external-link"><code>R/mkinsub.R</code></a></small> <div class="hidden name"><code>mkinmod.Rd</code></div> </div> @@ -155,33 +92,31 @@ variable, specifying the corresponding submodel as well as outgoing pathways (see examples).</p> <p>Print mkinmod objects in a way that the user finds his way to get to its components.</p> -<p>This is a convenience function to set up the lists used as arguments for -<code>mkinmod</code>.</p> </div> - <pre class="usage"><span class='fu'>mkinmod</span><span class='op'>(</span> - <span class='va'>...</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span>, - name <span class='op'>=</span> <span class='cn'>NULL</span>, - speclist <span class='op'>=</span> <span class='cn'>NULL</span>, - quiet <span class='op'>=</span> <span class='cn'>FALSE</span>, - verbose <span class='op'>=</span> <span class='cn'>FALSE</span>, - dll_dir <span class='op'>=</span> <span class='cn'>NULL</span>, - unload <span class='op'>=</span> <span class='cn'>FALSE</span>, - overwrite <span class='op'>=</span> <span class='cn'>FALSE</span> -<span class='op'>)</span> - -<span class='co'># S3 method for mkinmod</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='fu'>mkinsub</span><span class='op'>(</span><span class='va'>submodel</span>, to <span class='op'>=</span> <span class='cn'>NULL</span>, sink <span class='op'>=</span> <span class='cn'>TRUE</span>, full_name <span class='op'>=</span> <span class='cn'>NA</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinmod</span><span class="op">(</span> + <span class="va">...</span>, + use_of_ff <span class="op">=</span> <span class="st">"max"</span>, + name <span class="op">=</span> <span class="cn">NULL</span>, + speclist <span class="op">=</span> <span class="cn">NULL</span>, + quiet <span class="op">=</span> <span class="cn">FALSE</span>, + verbose <span class="op">=</span> <span class="cn">FALSE</span>, + dll_dir <span class="op">=</span> <span class="cn">NULL</span>, + unload <span class="op">=</span> <span class="cn">FALSE</span>, + overwrite <span class="op">=</span> <span class="cn">FALSE</span> +<span class="op">)</span> + +<span class="co"># S3 method for mkinmod</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span> + +<span class="fu">mkinsub</span><span class="op">(</span><span class="va">submodel</span>, to <span class="op">=</span> <span class="cn">NULL</span>, sink <span class="op">=</span> <span class="cn">TRUE</span>, full_name <span class="op">=</span> <span class="cn">NA</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>...</th> - <td><p>For each observed variable, a list as obtained by <code>mkinsub()</code> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>...</dt> +<dd><p>For each observed variable, a list as obtained by <code>mkinsub()</code> has to be specified as an argument (see examples). Currently, single first order kinetics "SFO", indeterminate order rate equation kinetics "IORE", or single first order with reversible binding "SFORB" are @@ -194,249 +129,234 @@ If the argument <code>use_of_ff</code> is set to "min" (default) and the model for the compartment is "SFO" or "SFORB", an additional <code>mkinsub()</code> argument can be <code>sink = FALSE</code>, effectively fixing the flux to sink to zero. -In print.mkinmod, this argument is currently not used.</p></td> - </tr> - <tr> - <th>use_of_ff</th> - <td><p>Specification of the use of formation fractions in the +In print.mkinmod, this argument is currently not used.</p></dd> +<dt>use_of_ff</dt> +<dd><p>Specification of the use of formation fractions in the model equations and, if applicable, the coefficient matrix. If "max", formation fractions are always used (default). If "min", a minimum use of formation fractions is made, i.e. each first-order pathway to a metabolite -has its own rate constant.</p></td> - </tr> - <tr> - <th>name</th> - <td><p>A name for the model. Should be a valid R object name.</p></td> - </tr> - <tr> - <th>speclist</th> - <td><p>The specification of the observed variables and their +has its own rate constant.</p></dd> +<dt>name</dt> +<dd><p>A name for the model. Should be a valid R object name.</p></dd> +<dt>speclist</dt> +<dd><p>The specification of the observed variables and their submodel types and pathways can be given as a single list using this -argument. Default is NULL.</p></td> - </tr> - <tr> - <th>quiet</th> - <td><p>Should messages be suppressed?</p></td> - </tr> - <tr> - <th>verbose</th> - <td><p>If <code>TRUE</code>, passed to <code><a href='https://rdrr.io/pkg/inline/man/cfunction.html'>inline::cfunction()</a></code> if -applicable to give detailed information about the C function being built.</p></td> - </tr> - <tr> - <th>dll_dir</th> - <td><p>Directory where an DLL object, if generated internally by -<code><a href='https://rdrr.io/pkg/inline/man/cfunction.html'>inline::cfunction()</a></code>, should be saved. The DLL will only be stored in a +argument. Default is NULL.</p></dd> +<dt>quiet</dt> +<dd><p>Should messages be suppressed?</p></dd> +<dt>verbose</dt> +<dd><p>If <code>TRUE</code>, passed to <code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code> if +applicable to give detailed information about the C function being built.</p></dd> +<dt>dll_dir</dt> +<dd><p>Directory where an DLL object, if generated internally by +<code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code>, should be saved. The DLL will only be stored in a permanent location for use in future sessions, if 'dll_dir' and 'name' -are specified.</p></td> - </tr> - <tr> - <th>unload</th> - <td><p>If a DLL from the target location in 'dll_dir' is already -loaded, should that be unloaded first?</p></td> - </tr> - <tr> - <th>overwrite</th> - <td><p>If a file exists at the target DLL location in 'dll_dir', -should this be overwritten?</p></td> - </tr> - <tr> - <th>x</th> - <td><p>An <code>mkinmod</code> object.</p></td> - </tr> - <tr> - <th>submodel</th> - <td><p>Character vector of length one to specify the submodel type. -See <code>mkinmod</code> for the list of allowed submodel names.</p></td> - </tr> - <tr> - <th>to</th> - <td><p>Vector of the names of the state variable to which a -transformation shall be included in the model.</p></td> - </tr> - <tr> - <th>sink</th> - <td><p>Should a pathway to sink be included in the model in addition to -the pathways to other state variables?</p></td> - </tr> - <tr> - <th>full_name</th> - <td><p>An optional name to be used e.g. for plotting fits +are specified.</p></dd> +<dt>unload</dt> +<dd><p>If a DLL from the target location in 'dll_dir' is already +loaded, should that be unloaded first?</p></dd> +<dt>overwrite</dt> +<dd><p>If a file exists at the target DLL location in 'dll_dir', +should this be overwritten?</p></dd> +<dt>x</dt> +<dd><p>An <code>mkinmod</code> object.</p></dd> +<dt>submodel</dt> +<dd><p>Character vector of length one to specify the submodel type. +See <code>mkinmod</code> for the list of allowed submodel names.</p></dd> +<dt>to</dt> +<dd><p>Vector of the names of the state variable to which a +transformation shall be included in the model.</p></dd> +<dt>sink</dt> +<dd><p>Should a pathway to sink be included in the model in addition to +the pathways to other state variables?</p></dd> +<dt>full_name</dt> +<dd><p>An optional name to be used e.g. for plotting fits performed with the model. You can use non-ASCII characters here, but then your R code will not be portable, <em>i.e.</em> may produce unintended plot -results on other operating systems or system configurations.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>A list of class <code>mkinmod</code> for use with <code><a href='mkinfit.html'>mkinfit()</a></code>, +results on other operating systems or system configurations.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>A list of class <code>mkinmod</code> for use with <code><a href="mkinfit.html">mkinfit()</a></code>, containing, among others,</p> -<dt>diffs</dt><dd><p>A vector of string representations of differential equations, one for +<dl><dt>diffs</dt> +<dd><p>A vector of string representations of differential equations, one for each modelling variable.</p></dd> -<dt>map</dt><dd><p>A list containing named character vectors for each observed variable, +<dt>map</dt> +<dd><p>A list containing named character vectors for each observed variable, specifying the modelling variables by which it is represented.</p></dd> -<dt>use_of_ff</dt><dd><p>The content of <code>use_of_ff</code> is passed on in this list component.</p></dd> -<dt>deg_func</dt><dd><p>If generated, a function containing the solution of the degradation +<dt>use_of_ff</dt> +<dd><p>The content of <code>use_of_ff</code> is passed on in this list component.</p></dd> +<dt>deg_func</dt> +<dd><p>If generated, a function containing the solution of the degradation model.</p></dd> -<dt>coefmat</dt><dd><p>The coefficient matrix, if the system of differential equations can be +<dt>coefmat</dt> +<dd><p>The coefficient matrix, if the system of differential equations can be represented by one.</p></dd> -<dt>cf</dt><dd><p>If generated, a compiled function calculating the derivatives as +<dt>cf</dt> +<dd><p>If generated, a compiled function calculating the derivatives as returned by cfunction.</p></dd> - -A list for use with mkinmod. - - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - +</dl><p>A list for use with <code>mkinmod</code>.</p> + </div> + <div id="details"> + <h2>Details</h2> <p>For the definition of model types and their parameters, the equations given in the FOCUS and NAFTA guidance documents are used.</p> <p>For kinetic models with more than one observed variable, a symbolic solution of the system of differential equations is included in the resulting mkinmod object in some cases, speeding up the solution.</p> -<p>If a C compiler is found by <code><a href='https://rdrr.io/pkg/pkgbuild/man/has_compiler.html'>pkgbuild::has_compiler()</a></code> and there +<p>If a C compiler is found by <code><a href="https://rdrr.io/pkg/pkgbuild/man/has_compiler.html" class="external-link">pkgbuild::has_compiler()</a></code> and there is more than one observed variable in the specification, C code is generated for evaluating the differential equations, compiled using -<code><a href='https://rdrr.io/pkg/inline/man/cfunction.html'>inline::cfunction()</a></code> and added to the resulting mkinmod object.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - +<code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code> and added to the resulting mkinmod object.</p> + </div> + <div id="note"> + <h2>Note</h2> <p>The IORE submodel is not well tested for metabolites. When using this model for metabolites, you may want to read the note in the help -page to <a href='mkinfit.html'>mkinfit</a>.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence +page to <a href="mkinfit.html">mkinfit</a>.</p> + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> <p>NAFTA Technical Working Group on Pesticides (not dated) Guidance for Evaluating and Calculating Degradation Kinetics in Environmental Media</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># Specify the SFO model (this is not needed any more, as we can now mkinfit("SFO", ...)</span> -<span class='va'>SFO</span> <span class='op'><-</span> <span class='fu'>mkinmod</span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> - -<span class='co'># One parent compound, one metabolite, both single first order</span> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'>mkinmod</span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span><span class='op'>)</span> -</div><div class='output co'>#> <mkinmod> model generated with -#> Use of formation fractions $use_of_ff: max -#> Specification $spec: -#> $parent -#> $type: SFO; $to: m1; $sink: TRUE -#> $m1 -#> $type: SFO; $sink: TRUE -#> Coefficient matrix $coefmat available -#> Compiled model $cf available -#> Differential equations: -#> d_parent/dt = - k_parent * parent -#> d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1</div><div class='input'> -<span class='co'># \dontrun{</span> - <span class='va'>fit_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> - <span class='co'># Now supplying compound names used for plotting, and write to user defined location</span> - <span class='co'># We need to choose a path outside the session tempdir because this gets removed</span> - <span class='va'>DLL_dir</span> <span class='op'><-</span> <span class='st'>"~/.local/share/mkin"</span> - <span class='kw'>if</span> <span class='op'>(</span><span class='op'>!</span><span class='fu'><a href='https://rdrr.io/r/base/files2.html'>dir.exists</a></span><span class='op'>(</span><span class='va'>DLL_dir</span><span class='op'>)</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/files2.html'>dir.create</a></span><span class='op'>(</span><span class='va'>DLL_dir</span><span class='op'>)</span> - <span class='va'>SFO_SFO.2</span> <span class='op'><-</span> <span class='fu'>mkinmod</span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span>, full_name <span class='op'>=</span> <span class='st'>"Test compound"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span>, full_name <span class='op'>=</span> <span class='st'>"Metabolite M1"</span><span class='op'>)</span>, - name <span class='op'>=</span> <span class='st'>"SFO_SFO"</span>, dll_dir <span class='op'>=</span> <span class='va'>DLL_dir</span>, unload <span class='op'>=</span> <span class='cn'>TRUE</span>, overwrite <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Copied DLL from /tmp/Rtmp1acwPp/fileb9e34769fb8fe.so to /home/jranke/.local/share/mkin/SFO_SFO.so</span></div><div class='input'><span class='co'># Now we can save the model and restore it in a new session</span> -<span class='fu'><a href='https://rdrr.io/r/base/readRDS.html'>saveRDS</a></span><span class='op'>(</span><span class='va'>SFO_SFO.2</span>, file <span class='op'>=</span> <span class='st'>"~/SFO_SFO.rds"</span><span class='op'>)</span> -<span class='co'># Terminate the R session here if you would like to check, and then do</span> -<span class='kw'><a href='https://rdrr.io/r/base/library.html'>library</a></span><span class='op'>(</span><span class='va'><a href='https://pkgdown.jrwb.de/mkin/'>mkin</a></span><span class='op'>)</span> -<span class='va'>SFO_SFO.3</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/readRDS.html'>readRDS</a></span><span class='op'>(</span><span class='st'>"~/SFO_SFO.rds"</span><span class='op'>)</span> -<span class='va'>fit_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.3</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> -<span class='co'># Show details of creating the C function</span> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'>mkinmod</span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, verbose <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> Program source: -#> 1: #include <R.h> -#> 2: -#> 3: -#> 4: static double parms [3]; -#> 5: #define k_parent parms[0] -#> 6: #define f_parent_to_m1 parms[1] -#> 7: #define k_m1 parms[2] -#> 8: -#> 9: void initpar(void (* odeparms)(int *, double *)) { -#> 10: int N = 3; -#> 11: odeparms(&N, parms); -#> 12: } -#> 13: -#> 14: -#> 15: void diffs ( int * n, double * t, double * y, double * f, double * rpar, int * ipar ) { -#> 16: -#> 17: f[0] = - k_parent * y[0]; -#> 18: f[1] = + f_parent_to_m1 * k_parent * y[0] - k_m1 * y[1]; -#> 19: }</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='co'># The symbolic solution which is available in this case is not</span> -<span class='co'># made for human reading but for speed of computation</span> -<span class='va'>SFO_SFO</span><span class='op'>$</span><span class='va'>deg_func</span> -</div><div class='output co'>#> function (observed, odeini, odeparms) -#> { -#> predicted <- numeric(0) -#> with(as.list(odeparms), { -#> t <- observed[observed$name == "parent", "time"] -#> predicted <<- c(predicted, SFO.solution(t, odeini["parent"], -#> k_parent)) -#> t <- observed[observed$name == "m1", "time"] -#> predicted <<- c(predicted, (((k_m1 - k_parent) * odeini["m1"] - -#> f_parent_to_m1 * k_parent * odeini["parent"]) * exp(-k_m1 * -#> t) + f_parent_to_m1 * k_parent * odeini["parent"] * -#> exp(-k_parent * t))/(k_m1 - k_parent)) -#> }) -#> return(predicted) -#> } -#> <environment: 0x55555a720040></div><div class='input'> -<span class='co'># If we have several parallel metabolites</span> -<span class='co'># (compare tests/testthat/test_synthetic_data_for_UBA_2014.R)</span> -<span class='va'>m_synth_DFOP_par</span> <span class='op'><-</span> <span class='fu'>mkinmod</span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'>mkinsub</span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - -<span class='va'>fit_DFOP_par_c</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_DFOP_par</span>, - <span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>12</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># Specify the SFO model (this is not needed any more, as we can now mkinfit("SFO", ...)</span></span> +<span class="r-in"><span class="va">SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span>parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># One parent compound, one metabolite, both single first order</span></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">SFO_SFO</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> +<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> +<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> +<span class="r-out co"><span class="r-pr">#></span> $parent</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: m1; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> $m1</span> +<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> +<span class="r-out co"><span class="r-pr">#></span> Coefficient matrix $coefmat available</span> +<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> +<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># Now supplying compound names used for plotting, and write to user defined location</span></span> +<span class="r-in"> <span class="co"># We need to choose a path outside the session tempdir because this gets removed</span></span> +<span class="r-in"> <span class="va">DLL_dir</span> <span class="op"><-</span> <span class="st">"~/.local/share/mkin"</span></span> +<span class="r-in"> <span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.exists</a></span><span class="op">(</span><span class="va">DLL_dir</span><span class="op">)</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.create</a></span><span class="op">(</span><span class="va">DLL_dir</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">SFO_SFO.2</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span>, full_name <span class="op">=</span> <span class="st">"Test compound"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, full_name <span class="op">=</span> <span class="st">"Metabolite M1"</span><span class="op">)</span>,</span> +<span class="r-in"> name <span class="op">=</span> <span class="st">"SFO_SFO"</span>, dll_dir <span class="op">=</span> <span class="va">DLL_dir</span>, unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Copied DLL from /tmp/RtmpNObdrK/filecabc85d9446.so to /home/jranke/.local/share/mkin/SFO_SFO.so</span> +<span class="r-in"><span class="co"># Now we can save the model and restore it in a new session</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/readRDS.html" class="external-link">saveRDS</a></span><span class="op">(</span><span class="va">SFO_SFO.2</span>, file <span class="op">=</span> <span class="st">"~/SFO_SFO.rds"</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Terminate the R session here if you would like to check, and then do</span></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> +<span class="r-in"><span class="va">SFO_SFO.3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/readRDS.html" class="external-link">readRDS</a></span><span class="op">(</span><span class="st">"~/SFO_SFO.rds"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.3</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Show details of creating the C function</span></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Program source:</span> +<span class="r-out co"><span class="r-pr">#></span> 1: #include <R.h></span> +<span class="r-out co"><span class="r-pr">#></span> 2: </span> +<span class="r-out co"><span class="r-pr">#></span> 3: </span> +<span class="r-out co"><span class="r-pr">#></span> 4: static double parms [3];</span> +<span class="r-out co"><span class="r-pr">#></span> 5: #define k_parent parms[0]</span> +<span class="r-out co"><span class="r-pr">#></span> 6: #define f_parent_to_m1 parms[1]</span> +<span class="r-out co"><span class="r-pr">#></span> 7: #define k_m1 parms[2]</span> +<span class="r-out co"><span class="r-pr">#></span> 8: </span> +<span class="r-out co"><span class="r-pr">#></span> 9: void initpar(void (* odeparms)(int *, double *)) {</span> +<span class="r-out co"><span class="r-pr">#></span> 10: int N = 3;</span> +<span class="r-out co"><span class="r-pr">#></span> 11: odeparms(&N, parms);</span> +<span class="r-out co"><span class="r-pr">#></span> 12: }</span> +<span class="r-out co"><span class="r-pr">#></span> 13: </span> +<span class="r-out co"><span class="r-pr">#></span> 14: </span> +<span class="r-out co"><span class="r-pr">#></span> 15: void diffs ( int * n, double * t, double * y, double * f, double * rpar, int * ipar ) {</span> +<span class="r-out co"><span class="r-pr">#></span> 16: </span> +<span class="r-out co"><span class="r-pr">#></span> 17: f[0] = - k_parent * y[0];</span> +<span class="r-out co"><span class="r-pr">#></span> 18: f[1] = + f_parent_to_m1 * k_parent * y[0] - k_m1 * y[1];</span> +<span class="r-out co"><span class="r-pr">#></span> 19: }</span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The symbolic solution which is available in this case is not</span></span> +<span class="r-in"><span class="co"># made for human reading but for speed of computation</span></span> +<span class="r-in"><span class="va">SFO_SFO</span><span class="op">$</span><span class="va">deg_func</span></span> +<span class="r-out co"><span class="r-pr">#></span> function (observed, odeini, odeparms) </span> +<span class="r-out co"><span class="r-pr">#></span> {</span> +<span class="r-out co"><span class="r-pr">#></span> predicted <- numeric(0)</span> +<span class="r-out co"><span class="r-pr">#></span> with(as.list(odeparms), {</span> +<span class="r-out co"><span class="r-pr">#></span> t <- observed[observed$name == "parent", "time"]</span> +<span class="r-out co"><span class="r-pr">#></span> predicted <<- c(predicted, SFO.solution(t, odeini["parent"], </span> +<span class="r-out co"><span class="r-pr">#></span> k_parent))</span> +<span class="r-out co"><span class="r-pr">#></span> t <- observed[observed$name == "m1", "time"]</span> +<span class="r-out co"><span class="r-pr">#></span> predicted <<- c(predicted, (((k_m1 - k_parent) * odeini["m1"] - </span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 * k_parent * odeini["parent"]) * exp(-k_m1 * </span> +<span class="r-out co"><span class="r-pr">#></span> t) + f_parent_to_m1 * k_parent * odeini["parent"] * </span> +<span class="r-out co"><span class="r-pr">#></span> exp(-k_parent * t))/(k_m1 - k_parent))</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> return(predicted)</span> +<span class="r-out co"><span class="r-pr">#></span> }</span> +<span class="r-out co"><span class="r-pr">#></span> <environment: 0x5555673b8fd0></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># If we have several parallel metabolites</span></span> +<span class="r-in"><span class="co"># (compare tests/testthat/test_synthetic_data_for_UBA_2014.R)</span></span> +<span class="r-in"><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">fit_DFOP_par_c</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>,</span> +<span class="r-in"> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinparplot-1.png b/docs/reference/mkinparplot-1.png Binary files differindex c9ed49eb..fff98391 100644 --- a/docs/reference/mkinparplot-1.png +++ b/docs/reference/mkinparplot-1.png diff --git a/docs/reference/mkinparplot.html b/docs/reference/mkinparplot.html index c298f5d2..2d7f6228 100644 --- 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data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ mkinfit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ mkinfit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,98 +59,90 @@ mkinfit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to plot the confidence intervals obtained using mkinfit</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinparplot.R'><code>R/mkinparplot.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinparplot.R" class="external-link"><code>R/mkinparplot.R</code></a></small> <div class="hidden name"><code>mkinparplot.Rd</code></div> </div> <div class="ref-description"> <p>This function plots the confidence intervals for the parameters fitted using -<code><a href='mkinfit.html'>mkinfit</a></code>.</p> +<code><a href="mkinfit.html">mkinfit</a></code>.</p> </div> - <pre class="usage"><span class='fu'>mkinparplot</span><span class='op'>(</span><span class='va'>object</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A fit represented in an <code><a href='mkinfit.html'>mkinfit</a></code> object.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinparplot</span><span class="op">(</span><span class="va">object</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Nothing is returned by this function, as it is called for its side effect, namely to produce a plot.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># \dontrun{</span> -<span class='va'>model</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - T245 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"phenol"</span><span class='op'>)</span>, sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - phenol <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"anisole"</span><span class='op'>)</span><span class='op'>)</span>, - anisole <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>model</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>mccall81_245T</span>, <span class='va'>soil</span> <span class='op'>==</span> <span class='st'>"Commerce"</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='output co'>#> <span class='warning'>Warning: Optimisation did not converge:</span> -#> <span class='warning'>false convergence (8)</span></div><div class='input'><span class='fu'>mkinparplot</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='mkinparplot-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> T245 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"phenol"</span><span class="op">)</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> phenol <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"anisole"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> anisole <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">mkinparplot</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mkinparplot-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinplot.html b/docs/reference/mkinplot.html index b20a8c96..896c30a0 100644 --- a/docs/reference/mkinplot.html +++ b/docs/reference/mkinplot.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta 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It now only calls the plot method -plot.mkinfit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Plot the observed data and the fitted model of an mkinfit object — mkinplot • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Plot the observed data and the fitted model of an mkinfit object — mkinplot"><meta property="og:description" content="Deprecated function. It now only calls the plot method +plot.mkinfit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ plot.mkinfit." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ plot.mkinfit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ plot.mkinfit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,89 +59,76 @@ plot.mkinfit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Plot the observed data and the fitted model of an mkinfit object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/plot.mkinfit.R'><code>R/plot.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mkinfit.R" class="external-link"><code>R/plot.mkinfit.R</code></a></small> <div class="hidden name"><code>mkinplot.Rd</code></div> </div> <div class="ref-description"> <p>Deprecated function. It now only calls the plot method -<code><a href='plot.mkinfit.html'>plot.mkinfit</a></code>.</p> +<code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p> </div> - <pre class="usage"><span class='fu'>mkinplot</span><span class='op'>(</span><span class='va'>fit</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>fit</th> - <td><p>an object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>further arguments passed to <code><a href='plot.mkinfit.html'>plot.mkinfit</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinplot</span><span class="op">(</span><span class="va">fit</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>fit</dt> +<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>...</dt> +<dd><p>further arguments passed to <code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinpredict.html b/docs/reference/mkinpredict.html index 5775ba62..b52d9ece 100644 --- a/docs/reference/mkinpredict.html +++ b/docs/reference/mkinpredict.html @@ -1,69 +1,14 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - 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- - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +kinetic parameters and initial values for the state variables."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ kinetic parameters and initial values for the state variables." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ kinetic parameters and initial values for the state variables." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ kinetic parameters and initial values for the state variables." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,343 +60,325 @@ kinetic parameters and initial values for the state variables." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Produce predictions from a kinetic model using specific parameters</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinpredict.R'><code>R/mkinpredict.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinpredict.R" class="external-link"><code>R/mkinpredict.R</code></a></small> <div class="hidden name"><code>mkinpredict.Rd</code></div> </div> <div class="ref-description"> <p>This function produces a time series for all the observed variables in a -kinetic model as specified by <code><a href='mkinmod.html'>mkinmod</a></code>, using a specific set of +kinetic model as specified by <code><a href="mkinmod.html">mkinmod</a></code>, using a specific set of kinetic parameters and initial values for the state variables.</p> </div> - <pre class="usage"><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>x</span>, <span class='va'>odeparms</span>, <span class='va'>odeini</span>, <span class='va'>outtimes</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for mkinmod</span> -<span class='fu'>mkinpredict</span><span class='op'>(</span> - <span class='va'>x</span>, - odeparms <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent_sink <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - odeini <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, - outtimes <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>120</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, - use_compiled <span class='op'>=</span> <span class='st'>"auto"</span>, - method.ode <span class='op'>=</span> <span class='st'>"lsoda"</span>, - atol <span class='op'>=</span> <span class='fl'>1e-08</span>, - rtol <span class='op'>=</span> <span class='fl'>1e-10</span>, - map_output <span class='op'>=</span> <span class='cn'>TRUE</span>, - na_stop <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='co'># S3 method for mkinfit</span> -<span class='fu'>mkinpredict</span><span class='op'>(</span> - <span class='va'>x</span>, - odeparms <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>bparms.ode</span>, - odeini <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>bparms.state</span>, - outtimes <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>120</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, - use_compiled <span class='op'>=</span> <span class='st'>"auto"</span>, - method.ode <span class='op'>=</span> <span class='st'>"lsoda"</span>, - atol <span class='op'>=</span> <span class='fl'>1e-08</span>, - rtol <span class='op'>=</span> <span class='fl'>1e-10</span>, - map_output <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">x</span>, <span class="va">odeparms</span>, <span class="va">odeini</span>, <span class="va">outtimes</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for mkinmod</span> +<span class="fu">mkinpredict</span><span class="op">(</span> + <span class="va">x</span>, + odeparms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent_sink <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>, + odeini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, + outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>, + solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, + use_compiled <span class="op">=</span> <span class="st">"auto"</span>, + method.ode <span class="op">=</span> <span class="st">"lsoda"</span>, + atol <span class="op">=</span> <span class="fl">1e-08</span>, + rtol <span class="op">=</span> <span class="fl">1e-10</span>, + map_output <span class="op">=</span> <span class="cn">TRUE</span>, + na_stop <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="co"># S3 method for mkinfit</span> +<span class="fu">mkinpredict</span><span class="op">(</span> + <span class="va">x</span>, + odeparms <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.ode</span>, + odeini <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.state</span>, + outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>, + solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, + use_compiled <span class="op">=</span> <span class="st">"auto"</span>, + method.ode <span class="op">=</span> <span class="st">"lsoda"</span>, + atol <span class="op">=</span> <span class="fl">1e-08</span>, + rtol <span class="op">=</span> <span class="fl">1e-10</span>, + map_output <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>A kinetic model as produced by <code><a href='mkinmod.html'>mkinmod</a></code>, or a kinetic -fit as fitted by <code><a href='mkinfit.html'>mkinfit</a></code>. In the latter case, the fitted -parameters are used for the prediction.</p></td> - </tr> - <tr> - <th>odeparms</th> - <td><p>A numeric vector specifying the parameters used in the + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>A kinetic model as produced by <code><a href="mkinmod.html">mkinmod</a></code>, or a kinetic +fit as fitted by <code><a href="mkinfit.html">mkinfit</a></code>. In the latter case, the fitted +parameters are used for the prediction.</p></dd> +<dt>odeparms</dt> +<dd><p>A numeric vector specifying the parameters used in the kinetic model, which is generally defined as a set of ordinary -differential equations.</p></td> - </tr> - <tr> - <th>odeini</th> - <td><p>A numeric vector containing the initial values of the state +differential equations.</p></dd> +<dt>odeini</dt> +<dd><p>A numeric vector containing the initial values of the state variables of the model. Note that the state variables can differ from the -observed variables, for example in the case of the SFORB model.</p></td> - </tr> - <tr> - <th>outtimes</th> - <td><p>A numeric vector specifying the time points for which model -predictions should be generated.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to the ode solver in case such a -solver is used.</p></td> - </tr> - <tr> - <th>solution_type</th> - <td><p>The method that should be used for producing the +observed variables, for example in the case of the SFORB model.</p></dd> +<dt>outtimes</dt> +<dd><p>A numeric vector specifying the time points for which model +predictions should be generated.</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to the ode solver in case such a +solver is used.</p></dd> +<dt>solution_type</dt> +<dd><p>The method that should be used for producing the predictions. This should generally be "analytical" if there is only one observed variable, and usually "deSolve" in the case of several observed variables. The third possibility "eigen" is faster but not applicable to -some models e.g. using FOMC for the parent compound.</p></td> - </tr> - <tr> - <th>use_compiled</th> - <td><p>If set to <code>FALSE</code>, no compiled version of the -<code><a href='mkinmod.html'>mkinmod</a></code> model is used, even if is present.</p></td> - </tr> - <tr> - <th>method.ode</th> - <td><p>The solution method passed via <code>mkinpredict</code> +some models e.g. using FOMC for the parent compound.</p></dd> +<dt>use_compiled</dt> +<dd><p>If set to <code>FALSE</code>, no compiled version of the +<code><a href="mkinmod.html">mkinmod</a></code> model is used, even if is present.</p></dd> +<dt>method.ode</dt> +<dd><p>The solution method passed via <code>mkinpredict</code> to <code>ode</code> in case the solution type is "deSolve". The default -"lsoda" is performant, but sometimes fails to converge.</p></td> - </tr> - <tr> - <th>atol</th> - <td><p>Absolute error tolerance, passed to <code>ode</code>. Default -is 1e-8, lower than in <code>lsoda</code>.</p></td> - </tr> - <tr> - <th>rtol</th> - <td><p>Absolute error tolerance, passed to <code>ode</code>. Default -is 1e-10, much lower than in <code>lsoda</code>.</p></td> - </tr> - <tr> - <th>map_output</th> - <td><p>Boolean to specify if the output should list values for +"lsoda" is performant, but sometimes fails to converge.</p></dd> +<dt>atol</dt> +<dd><p>Absolute error tolerance, passed to <code>ode</code>. Default +is 1e-8, lower than in <code>lsoda</code>.</p></dd> +<dt>rtol</dt> +<dd><p>Absolute error tolerance, passed to <code>ode</code>. Default +is 1e-10, much lower than in <code>lsoda</code>.</p></dd> +<dt>map_output</dt> +<dd><p>Boolean to specify if the output should list values for the observed variables (default) or for all state variables (if set to FALSE). Setting this to FALSE has no effect for analytical solutions, -as these always return mapped output.</p></td> - </tr> - <tr> - <th>na_stop</th> - <td><p>Should it be an error if deSolve::ode returns NaN values</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +as these always return mapped output.</p></dd> +<dt>na_stop</dt> +<dd><p>Should it be an error if deSolve::ode returns NaN values</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A matrix with the numeric solution in wide format</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -<span class='co'># Compare solution types</span> -<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - solution_type <span class='op'>=</span> <span class='st'>"analytical"</span><span class='op'>)</span> -</div><div class='output co'>#> time degradinol -#> 0 0 100.0000000 -#> 1 1 74.0818221 -#> 2 2 54.8811636 -#> 3 3 40.6569660 -#> 4 4 30.1194212 -#> 5 5 22.3130160 -#> 6 6 16.5298888 -#> 7 7 12.2456428 -#> 8 8 9.0717953 -#> 9 9 6.7205513 -#> 10 10 4.9787068 -#> 11 11 3.6883167 -#> 12 12 2.7323722 -#> 13 13 2.0241911 -#> 14 14 1.4995577 -#> 15 15 1.1108997 -#> 16 16 0.8229747 -#> 17 17 0.6096747 -#> 18 18 0.4516581 -#> 19 19 0.3345965 -#> 20 20 0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span> -</div><div class='output co'>#> time degradinol -#> 0 0 100.0000000 -#> 1 1 74.0818221 -#> 2 2 54.8811636 -#> 3 3 40.6569660 -#> 4 4 30.1194212 -#> 5 5 22.3130160 -#> 6 6 16.5298888 -#> 7 7 12.2456428 -#> 8 8 9.0717953 -#> 9 9 6.7205513 -#> 10 10 4.9787068 -#> 11 11 3.6883167 -#> 12 12 2.7323722 -#> 13 13 2.0241911 -#> 14 14 1.4995577 -#> 15 15 1.1108996 -#> 16 16 0.8229747 -#> 17 17 0.6096747 -#> 18 18 0.4516581 -#> 19 19 0.3345965 -#> 20 20 0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -</div><div class='output co'>#> time degradinol -#> 0 0 100.0000000 -#> 1 1 74.0818221 -#> 2 2 54.8811636 -#> 3 3 40.6569660 -#> 4 4 30.1194212 -#> 5 5 22.3130160 -#> 6 6 16.5298888 -#> 7 7 12.2456428 -#> 8 8 9.0717953 -#> 9 9 6.7205513 -#> 10 10 4.9787068 -#> 11 11 3.6883167 -#> 12 12 2.7323722 -#> 13 13 2.0241911 -#> 14 14 1.4995577 -#> 15 15 1.1108996 -#> 16 16 0.8229747 -#> 17 17 0.6096747 -#> 18 18 0.4516581 -#> 19 19 0.3345965 -#> 20 20 0.2478752</div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - solution_type <span class='op'>=</span> <span class='st'>"eigen"</span><span class='op'>)</span> -</div><div class='output co'>#> time degradinol -#> 0 0 100.0000000 -#> 1 1 74.0818221 -#> 2 2 54.8811636 -#> 3 3 40.6569660 -#> 4 4 30.1194212 -#> 5 5 22.3130160 -#> 6 6 16.5298888 -#> 7 7 12.2456428 -#> 8 8 9.0717953 -#> 9 9 6.7205513 -#> 10 10 4.9787068 -#> 11 11 3.6883167 -#> 12 12 2.7323722 -#> 13 13 2.0241911 -#> 14 14 1.4995577 -#> 15 15 1.1108997 -#> 16 16 0.8229747 -#> 17 17 0.6096747 -#> 18 18 0.4516581 -#> 19 19 0.3345965 -#> 20 20 0.2478752</div><div class='input'> -<span class='co'># Compare integration methods to analytical solution</span> -<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - solution_type <span class='op'>=</span> <span class='st'>"analytical"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - method <span class='op'>=</span> <span class='st'>"lsoda"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - method <span class='op'>=</span> <span class='st'>"ode45"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, <span class='fl'>0</span><span class='op'>:</span><span class='fl'>20</span>, - method <span class='op'>=</span> <span class='st'>"rk4"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>21</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2480043 </div><div class='input'><span class='co'># rk4 is not as precise here</span> - -<span class='co'># The number of output times used to make a lot of difference until the</span> -<span class='co'># default for atol was adjusted</span> -<span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2478752 </div><div class='input'><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_degradinol <span class='op'>=</span> <span class='fl'>0.3</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>degradinol <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>2001</span>,<span class='op'>]</span> -</div><div class='output co'>#> time degradinol -#> 20.0000000 0.2478752 </div><div class='input'> -<span class='co'># Comparison of the performance of solution types</span> -<span class='va'>SFO_SFO</span> <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='kw'>if</span><span class='op'>(</span><span class='kw'><a href='https://rdrr.io/r/base/library.html'>require</a></span><span class='op'>(</span><span class='va'><a href='http://rbenchmark.googlecode.com'>rbenchmark</a></span><span class='op'>)</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='https://rdrr.io/pkg/rbenchmark/man/benchmark.html'>benchmark</a></span><span class='op'>(</span>replications <span class='op'>=</span> <span class='fl'>10</span>, order <span class='op'>=</span> <span class='st'>"relative"</span>, columns <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"test"</span>, <span class='st'>"relative"</span>, <span class='st'>"elapsed"</span><span class='op'>)</span>, - eigen <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"eigen"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>, - deSolve_compiled <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>, - deSolve <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span>, - analytical <span class='op'>=</span> <span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>SFO_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.15</span>, f_parent_to_m1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_m1 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, m1 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, <span class='fu'><a href='https://rdrr.io/r/base/seq.html'>seq</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>20</span>, by <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - solution_type <span class='op'>=</span> <span class='st'>"analytical"</span>, use_compiled <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span><span class='op'>[</span><span class='fl'>201</span>,<span class='op'>]</span><span class='op'>)</span> -<span class='op'>}</span> -</div><div class='output co'>#> test relative elapsed -#> 2 deSolve_compiled 1.0 0.005 -#> 4 analytical 1.0 0.005 -#> 1 eigen 4.0 0.020 -#> 3 deSolve 46.2 0.231</div><div class='input'> -<span class='co'># \dontrun{</span> - <span class='co'># Predict from a fitted model</span> - <span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/utils/head.html'>head</a></span><span class='op'>(</span><span class='fu'>mkinpredict</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> time parent m1 -#> 0 0.0 82.49216 0.000000 -#> 0.1 0.1 80.00562 1.236394 -#> 0.2 0.2 77.59404 2.423201 -#> 0.3 0.3 75.25514 3.562040 -#> 0.4 0.4 72.98675 4.654478 -#> 0.5 0.5 70.78673 5.702033</div><div class='input'><span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Compare solution types</span></span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> +<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> +<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> +<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> +<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> +<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> +<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> +<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> +<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> +<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> +<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> +<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> +<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108997</span> +<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> +<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> +<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> +<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> +<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> +<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> +<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> +<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> +<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> +<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> +<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> +<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> +<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> +<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> +<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> +<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> +<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108996</span> +<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> +<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> +<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> +<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> +<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> +<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> +<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> +<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> +<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> +<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> +<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> +<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> +<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> +<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> +<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> +<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> +<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108996</span> +<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> +<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> +<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> +<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> +<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> +<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> +<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> +<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> +<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> +<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> +<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> +<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> +<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> +<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> +<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> +<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> +<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> +<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> +<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> +<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108997</span> +<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> +<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> +<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> +<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> +<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Compare integration methods to analytical solution</span></span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> method <span class="op">=</span> <span class="st">"lsoda"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> method <span class="op">=</span> <span class="st">"ode45"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span> +<span class="r-in"> method <span class="op">=</span> <span class="st">"rk4"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2480043 </span> +<span class="r-in"><span class="co"># rk4 is not as precise here</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The number of output times used to make a lot of difference until the</span></span> +<span class="r-in"><span class="co"># default for atol was adjusted</span></span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> +<span class="r-in"><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">2001</span>,<span class="op">]</span></span> +<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> +<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Comparison of the performance of solution types</span></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="kw">if</span><span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span>replications <span class="op">=</span> <span class="fl">10</span>, order <span class="op">=</span> <span class="st">"relative"</span>, columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span>,</span> +<span class="r-in"> eigen <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span> +<span class="r-in"> deSolve_compiled <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span> +<span class="r-in"> deSolve <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span> +<span class="r-in"> analytical <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"analytical"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-out co"><span class="r-pr">#></span> test relative elapsed</span> +<span class="r-out co"><span class="r-pr">#></span> 4 analytical 1.0 0.005</span> +<span class="r-out co"><span class="r-pr">#></span> 2 deSolve_compiled 1.2 0.006</span> +<span class="r-out co"><span class="r-pr">#></span> 1 eigen 4.2 0.021</span> +<span class="r-out co"><span class="r-pr">#></span> 3 deSolve 40.8 0.204</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="co"># Predict from a fitted model</span></span> +<span class="r-in"> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">f</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> time parent m1</span> +<span class="r-out co"><span class="r-pr">#></span> 0 0.0 82.49216 0.000000</span> +<span class="r-out co"><span class="r-pr">#></span> 0.1 0.1 80.00562 1.236394</span> +<span class="r-out co"><span class="r-pr">#></span> 0.2 0.2 77.59404 2.423201</span> +<span class="r-out co"><span class="r-pr">#></span> 0.3 0.3 75.25514 3.562040</span> +<span class="r-out co"><span class="r-pr">#></span> 0.4 0.4 72.98675 4.654478</span> +<span class="r-out co"><span class="r-pr">#></span> 0.5 0.5 70.78673 5.702033</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mkinresplot-1.png b/docs/reference/mkinresplot-1.png Binary files differindex 963aa5b7..97ccd762 100644 --- a/docs/reference/mkinresplot-1.png +++ b/docs/reference/mkinresplot-1.png diff --git a/docs/reference/mkinresplot.html b/docs/reference/mkinresplot.html index fe3150e7..54d612ef 100644 --- a/docs/reference/mkinresplot.html +++ b/docs/reference/mkinresplot.html @@ -1,70 +1,15 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Function to plot residuals stored in an mkin object — mkinresplot • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" 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mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Function to plot residuals stored in an mkin object — mkinresplot"><meta property="og:description" content="This function plots the residuals for the specified subset of the observed variables from an mkinfit object. A combined plot of the fitted model and the residuals can be obtained using plot.mkinfit using the -argument show_residuals = TRUE." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +argument show_residuals = TRUE."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ argument show_residuals = TRUE." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ argument show_residuals = TRUE." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ argument show_residuals = TRUE." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,167 +61,137 @@ argument show_residuals = TRUE." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Function to plot residuals stored in an mkin object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mkinresplot.R'><code>R/mkinresplot.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinresplot.R" class="external-link"><code>R/mkinresplot.R</code></a></small> <div class="hidden name"><code>mkinresplot.Rd</code></div> </div> <div class="ref-description"> <p>This function plots the residuals for the specified subset of the observed variables from an mkinfit object. A combined plot of the fitted model and -the residuals can be obtained using <code><a href='plot.mkinfit.html'>plot.mkinfit</a></code> using the +the residuals can be obtained using <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> using the argument <code>show_residuals = TRUE</code>.</p> </div> - <pre class="usage"><span class='fu'>mkinresplot</span><span class='op'>(</span> - <span class='va'>object</span>, - obs_vars <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>object</span><span class='op'>$</span><span class='va'>mkinmod</span><span class='op'>$</span><span class='va'>map</span><span class='op'>)</span>, - xlim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1.1</span> <span class='op'>*</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='va'>object</span><span class='op'>$</span><span class='va'>data</span><span class='op'>$</span><span class='va'>time</span><span class='op'>)</span><span class='op'>)</span>, - standardized <span class='op'>=</span> <span class='cn'>FALSE</span>, - xlab <span class='op'>=</span> <span class='st'>"Time"</span>, - ylab <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/ifelse.html'>ifelse</a></span><span class='op'>(</span><span class='va'>standardized</span>, <span class='st'>"Standardized residual"</span>, <span class='st'>"Residual"</span><span class='op'>)</span>, - maxabs <span class='op'>=</span> <span class='st'>"auto"</span>, - legend <span class='op'>=</span> <span class='cn'>TRUE</span>, - lpos <span class='op'>=</span> <span class='st'>"topright"</span>, - col_obs <span class='op'>=</span> <span class='st'>"auto"</span>, - pch_obs <span class='op'>=</span> <span class='st'>"auto"</span>, - frame <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mkinresplot</span><span class="op">(</span> + <span class="va">object</span>, + obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>, + xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span><span class="op">)</span>, + standardized <span class="op">=</span> <span class="cn">FALSE</span>, + xlab <span class="op">=</span> <span class="st">"Time"</span>, + ylab <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="va">standardized</span>, <span class="st">"Standardized residual"</span>, <span class="st">"Residual"</span><span class="op">)</span>, + maxabs <span class="op">=</span> <span class="st">"auto"</span>, + legend <span class="op">=</span> <span class="cn">TRUE</span>, + lpos <span class="op">=</span> <span class="st">"topright"</span>, + col_obs <span class="op">=</span> <span class="st">"auto"</span>, + pch_obs <span class="op">=</span> <span class="st">"auto"</span>, + frame <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A fit represented in an <code><a href='mkinfit.html'>mkinfit</a></code> object.</p></td> - </tr> - <tr> - <th>obs_vars</th> - <td><p>A character vector of names of the observed variables for + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> +<dt>obs_vars</dt> +<dd><p>A character vector of names of the observed variables for which residuals should be plotted. Defaults to all observed variables in -the model</p></td> - </tr> - <tr> - <th>xlim</th> - <td><p>plot range in x direction.</p></td> - </tr> - <tr> - <th>standardized</th> - <td><p>Should the residuals be standardized by dividing by the -standard deviation given by the error model of the fit?</p></td> - </tr> - <tr> - <th>xlab</th> - <td><p>Label for the x axis.</p></td> - </tr> - <tr> - <th>ylab</th> - <td><p>Label for the y axis.</p></td> - </tr> - <tr> - <th>maxabs</th> - <td><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></td> - </tr> - <tr> - <th>legend</th> - <td><p>Should a legend be plotted?</p></td> - </tr> - <tr> - <th>lpos</th> - <td><p>Where should the legend be placed? Default is "topright". Will -be passed on to <code><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></code>.</p></td> - </tr> - <tr> - <th>col_obs</th> - <td><p>Colors for the observed variables.</p></td> - </tr> - <tr> - <th>pch_obs</th> - <td><p>Symbols to be used for the observed variables.</p></td> - </tr> - <tr> - <th>frame</th> - <td><p>Should a frame be drawn around the plots?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>further arguments passed to <code><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +the model</p></dd> +<dt>xlim</dt> +<dd><p>plot range in x direction.</p></dd> +<dt>standardized</dt> +<dd><p>Should the residuals be standardized by dividing by the +standard deviation given by the error model of the fit?</p></dd> +<dt>xlab</dt> +<dd><p>Label for the x axis.</p></dd> +<dt>ylab</dt> +<dd><p>Label for the y axis.</p></dd> +<dt>maxabs</dt> +<dd><p>Maximum absolute value of the residuals. This is used for the +scaling of the y axis and defaults to "auto".</p></dd> +<dt>legend</dt> +<dd><p>Should a legend be plotted?</p></dd> +<dt>lpos</dt> +<dd><p>Where should the legend be placed? Default is "topright". Will +be passed on to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code>.</p></dd> +<dt>col_obs</dt> +<dd><p>Colors for the observed variables.</p></dd> +<dt>pch_obs</dt> +<dd><p>Symbols to be used for the observed variables.</p></dd> +<dt>frame</dt> +<dd><p>Should a frame be drawn around the plots?</p></dd> +<dt>...</dt> +<dd><p>further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Nothing is returned by this function, as it is called for its side effect, namely to produce a plot.</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><code><a href='mkinplot.html'>mkinplot</a></code>, for a way to plot the data and the fitted -lines of the mkinfit object, and <code><a href='plot.mkinfit.html'>plot_res</a></code> for a function + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><code><a href="mkinplot.html">mkinplot</a></code>, for a way to plot the data and the fitted +lines of the mkinfit object, and <code><a href="plot.mkinfit.html">plot_res</a></code> for a function combining the plot of the fit and the residual plot.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke and Katrin Lindenberger</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>model</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span><span class='op'>)</span>, m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>model</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'>mkinresplot</span><span class='op'>(</span><span class='va'>fit</span>, <span class='st'>"m1"</span><span class='op'>)</span> -</div><div class='img'><img src='mkinresplot-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">mkinresplot</span><span class="op">(</span><span class="va">fit</span>, <span class="st">"m1"</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mkinresplot-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/mmkin-1.png b/docs/reference/mmkin-1.png Binary files differindex 701a6d6a..8ad9c11d 100644 --- a/docs/reference/mmkin-1.png +++ b/docs/reference/mmkin-1.png diff --git a/docs/reference/mmkin-2.png b/docs/reference/mmkin-2.png Binary files differindex 5277b389..da2a48a8 100644 --- a/docs/reference/mmkin-2.png +++ b/docs/reference/mmkin-2.png diff --git a/docs/reference/mmkin-3.png b/docs/reference/mmkin-3.png Binary files differindex 2659cd61..10d3f35b 100644 --- a/docs/reference/mmkin-3.png +++ b/docs/reference/mmkin-3.png diff --git a/docs/reference/mmkin-4.png b/docs/reference/mmkin-4.png Binary files differindex ae16ee79..132380a8 100644 --- a/docs/reference/mmkin-4.png +++ b/docs/reference/mmkin-4.png diff --git a/docs/reference/mmkin-5.png b/docs/reference/mmkin-5.png Binary files differindex 2b9dc831..4bfcc55e 100644 --- a/docs/reference/mmkin-5.png +++ b/docs/reference/mmkin-5.png diff --git a/docs/reference/mmkin.html b/docs/reference/mmkin.html index d7989c6b..4012df67 100644 --- a/docs/reference/mmkin.html +++ b/docs/reference/mmkin.html @@ -1,70 +1,15 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - 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- - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ datasets specified in its first two arguments." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ datasets specified in its first two arguments." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ datasets specified in its first two arguments." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,199 +61,191 @@ datasets specified in its first two arguments." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Fit one or more kinetic models with one or more state variables to one or more datasets</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/mmkin.R'><code>R/mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mmkin.R" class="external-link"><code>R/mmkin.R</code></a></small> <div class="hidden name"><code>mmkin.Rd</code></div> </div> <div class="ref-description"> - <p>This function calls <code><a href='mkinfit.html'>mkinfit</a></code> on all combinations of models and + <p>This function calls <code><a href="mkinfit.html">mkinfit</a></code> on all combinations of models and datasets specified in its first two arguments.</p> </div> - <pre class="usage"><span class='fu'>mmkin</span><span class='op'>(</span> - models <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, - <span class='va'>datasets</span>, - cores <span class='op'>=</span> <span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/Sys.info.html'>Sys.info</a></span><span class='op'>(</span><span class='op'>)</span><span class='op'>[</span><span class='st'>"sysname"</span><span class='op'>]</span> <span class='op'>==</span> <span class='st'>"Windows"</span><span class='op'>)</span> <span class='fl'>1</span> <span class='kw'>else</span> <span class='fu'>parallel</span><span class='fu'>::</span><span class='fu'><a href='https://rdrr.io/r/parallel/detectCores.html'>detectCores</a></span><span class='op'>(</span><span class='op'>)</span>, - cluster <span class='op'>=</span> <span class='cn'>NULL</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, <span class='va'>...</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">mmkin</span><span class="op">(</span> + models <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, + <span class="va">datasets</span>, + cores <span class="op">=</span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="fl">1</span> <span class="kw">else</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span>, + cluster <span class="op">=</span> <span class="cn">NULL</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>models</th> - <td><p>Either a character vector of shorthand names like -<code><a href='https://rdrr.io/r/base/c.html'>c("SFO", "FOMC", "DFOP", "HS", "SFORB")</a></code>, or an optionally named -list of <code><a href='mkinmod.html'>mkinmod</a></code> objects.</p></td> - </tr> - <tr> - <th>datasets</th> - <td><p>An optionally named list of datasets suitable as observed -data for <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>cores</th> - <td><p>The number of cores to be used for multicore processing. This + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>models</dt> +<dd><p>Either a character vector of shorthand names like +<code>c("SFO", "FOMC", "DFOP", "HS", "SFORB")</code>, or an optionally named +list of <code><a href="mkinmod.html">mkinmod</a></code> objects.</p></dd> +<dt>datasets</dt> +<dd><p>An optionally named list of datasets suitable as observed +data for <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>cores</dt> +<dd><p>The number of cores to be used for multicore processing. This is only used when the <code>cluster</code> argument is <code>NULL</code>. On Windows machines, cores > 1 is not supported, you need to use the <code>cluster</code> argument to use multiple logical processors. Per default, all cores -detected by <code><a href='https://rdrr.io/r/parallel/detectCores.html'>parallel::detectCores()</a></code> are used, except on Windows where -the default is 1.</p></td> - </tr> - <tr> - <th>cluster</th> - <td><p>A cluster as returned by <code>makeCluster</code> to be used -for parallel execution.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used.</p></td> - </tr> - <tr> - <th>x</th> - <td><p>An mmkin object.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>A two-dimensional <code><a href='https://rdrr.io/r/base/array.html'>array</a></code> of <code><a href='mkinfit.html'>mkinfit</a></code> -objects and/or try-errors that can be indexed using the model names for the +detected by <code><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">parallel::detectCores()</a></code> are used, except on Windows where +the default is 1.</p></dd> +<dt>cluster</dt> +<dd><p>A cluster as returned by <code><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makeCluster</a></code> to be used +for parallel execution.</p></dd> +<dt>...</dt> +<dd><p>Not used.</p></dd> +<dt>x</dt> +<dd><p>An mmkin object.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>A two-dimensional <code><a href="https://rdrr.io/r/base/array.html" class="external-link">array</a></code> of <code><a href="mkinfit.html">mkinfit</a></code>objects and/or try-errors that can be indexed using the model names for the first index (row index) and the dataset names for the second index (column index).</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><code><a href='[.mmkin.html'>[.mmkin</a></code> for subsetting, <code><a href='plot.mmkin.html'>plot.mmkin</a></code> for + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><code><a href="Extract.mmkin.html">[.mmkin</a></code> for subsetting, <code><a href="plot.mmkin.html">plot.mmkin</a></code> for plotting.</p></div> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># \dontrun{</span> -<span class='va'>m_synth_SFO_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M2"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>m_synth_FOMC_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M2"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>models</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>SFO_lin <span class='op'>=</span> <span class='va'>m_synth_SFO_lin</span>, FOMC_lin <span class='op'>=</span> <span class='va'>m_synth_FOMC_lin</span><span class='op'>)</span> -<span class='va'>datasets</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[</span><span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>]</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>datasets</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"Dataset"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>)</span> - -<span class='va'>time_default</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/system.time.html'>system.time</a></span><span class='op'>(</span><span class='va'>fits.0</span> <span class='op'><-</span> <span class='fu'>mmkin</span><span class='op'>(</span><span class='va'>models</span>, <span class='va'>datasets</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span> -<span class='va'>time_1</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/system.time.html'>system.time</a></span><span class='op'>(</span><span class='va'>fits.4</span> <span class='op'><-</span> <span class='fu'>mmkin</span><span class='op'>(</span><span class='va'>models</span>, <span class='va'>datasets</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span> - -<span class='va'>time_default</span> -</div><div class='output co'>#> user system elapsed -#> 4.491 0.397 1.634 </div><div class='input'><span class='va'>time_1</span> -</div><div class='output co'>#> user system elapsed -#> 5.491 0.000 5.492 </div><div class='input'> -<span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[[</span><span class='st'>"SFO_lin"</span>, <span class='fl'>2</span><span class='op'>]</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_M1 parent_sink M1_M2 M1_sink -#> 0.7340481 0.2659519 0.7505683 0.2494317 -#> -#> $distimes -#> DT50 DT90 -#> parent 0.877769 2.915885 -#> M1 2.325744 7.725956 -#> M2 33.720100 112.015749 -#> </div><div class='input'> -<span class='co'># plot.mkinfit handles rows or columns of mmkin result objects</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[</span><span class='fl'>1</span>, <span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='mmkin-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[</span><span class='fl'>1</span>, <span class='op'>]</span>, obs_var <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='mmkin-2.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[</span>, <span class='fl'>1</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='mmkin-3.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># Use double brackets to extract a single mkinfit object, which will be plotted</span> -<span class='co'># by plot.mkinfit and can be plotted using plot_sep</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[[</span><span class='fl'>1</span>, <span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span>, sep_obs <span class='op'>=</span> <span class='cn'>TRUE</span>, show_residuals <span class='op'>=</span> <span class='cn'>TRUE</span>, show_errmin <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='mmkin-4.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[[</span><span class='fl'>1</span>, <span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span><span class='op'>)</span> -<span class='co'># Plotting with mmkin (single brackets, extracting an mmkin object) does not</span> -<span class='co'># allow to plot the observed variables separately</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits.0</span><span class='op'>[</span><span class='fl'>1</span>, <span class='fl'>1</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='mmkin-5.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># On Windows, we can use multiple cores by making a cluster using the parallel</span> -<span class='co'># package, which gets loaded with mkin, and passing it to mmkin, e.g.</span> -<span class='va'>cl</span> <span class='op'><-</span> <span class='fu'>makePSOCKcluster</span><span class='op'>(</span><span class='fl'>12</span><span class='op'>)</span> -<span class='va'>f</span> <span class='op'><-</span> <span class='fu'>mmkin</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>A <span class='op'>=</span> <span class='va'>FOCUS_2006_A</span>, B <span class='op'>=</span> <span class='va'>FOCUS_2006_B</span>, C <span class='op'>=</span> <span class='va'>FOCUS_2006_C</span>, D <span class='op'>=</span> <span class='va'>FOCUS_2006_D</span><span class='op'>)</span>, - cluster <span class='op'>=</span> <span class='va'>cl</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -</div><div class='output co'>#> <mmkin> object -#> Status of individual fits: -#> -#> dataset -#> model A B C D -#> SFO OK OK OK OK -#> FOMC OK OK OK OK -#> DFOP OK OK OK OK -#> -#> OK: No warnings</div><div class='input'><span class='co'># We get false convergence for the FOMC fit to FOCUS_2006_A because this</span> -<span class='co'># dataset is really SFO, and the FOMC fit is overparameterised</span> -<span class='fu'>stopCluster</span><span class='op'>(</span><span class='va'>cl</span><span class='op'>)</span> -<span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">m_synth_FOMC_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">models</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>SFO_lin <span class="op">=</span> <span class="va">m_synth_SFO_lin</span>, FOMC_lin <span class="op">=</span> <span class="va">m_synth_FOMC_lin</span><span class="op">)</span></span> +<span class="r-in"><span class="va">datasets</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">datasets</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">time_default</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">fits.0</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">time_1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">fits.4</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">time_default</span></span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 6.055 1.405 2.191 </span> +<span class="r-in"><span class="va">time_1</span></span> +<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> +<span class="r-out co"><span class="r-pr">#></span> 6.746 0.004 6.750 </span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="st">"SFO_lin"</span>, <span class="fl">2</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_M1 parent_sink M1_M2 M1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 0.7340481 0.2659519 0.7505683 0.2494317 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 0.877769 2.915885</span> +<span class="r-out co"><span class="r-pr">#></span> M1 2.325744 7.725956</span> +<span class="r-out co"><span class="r-pr">#></span> M2 33.720100 112.015749</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># plot.mkinfit handles rows or columns of mmkin result objects</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mmkin-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="op">]</span>, obs_var <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mmkin-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span>, <span class="fl">1</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mmkin-3.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># Use double brackets to extract a single mkinfit object, which will be plotted</span></span> +<span class="r-in"><span class="co"># by plot.mkinfit and can be plotted using plot_sep</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mmkin-4.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Plotting with mmkin (single brackets, extracting an mmkin object) does not</span></span> +<span class="r-in"><span class="co"># allow to plot the observed variables separately</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="mmkin-5.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># On Windows, we can use multiple cores by making a cluster using the parallel</span></span> +<span class="r-in"><span class="co"># package, which gets loaded with mkin, and passing it to mmkin, e.g.</span></span> +<span class="r-in"><span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="fl">12</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>A <span class="op">=</span> <span class="va">FOCUS_2006_A</span>, B <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, C <span class="op">=</span> <span class="va">FOCUS_2006_C</span>, D <span class="op">=</span> <span class="va">FOCUS_2006_D</span><span class="op">)</span>,</span> +<span class="r-in"> cluster <span class="op">=</span> <span class="va">cl</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> +<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> dataset</span> +<span class="r-out co"><span class="r-pr">#></span> model A B C D </span> +<span class="r-out co"><span class="r-pr">#></span> SFO OK OK OK OK</span> +<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK OK OK</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP OK OK OK OK</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> +<span class="r-in"><span class="co"># We get false convergence for the FOMC fit to FOCUS_2006_A because this</span></span> +<span class="r-in"><span class="co"># dataset is really SFO, and the FOMC fit is overparameterised</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/nafta-1.png b/docs/reference/nafta-1.png Binary files differindex 4f0d7833..5d2d434b 100644 --- a/docs/reference/nafta-1.png +++ b/docs/reference/nafta-1.png diff --git a/docs/reference/nafta.html b/docs/reference/nafta.html index 29e03251..28e44864 100644 --- a/docs/reference/nafta.html +++ b/docs/reference/nafta.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Evaluate parent kinetics using the NAFTA guidance — nafta • mkin</title> - - -<!-- jquery --> -<script 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/> -<meta property="og:description" content="The function fits the SFO, IORE and DFOP models using mmkin +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Evaluate parent kinetics using the NAFTA guidance — nafta • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" 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integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Evaluate parent kinetics using the NAFTA guidance — nafta"><meta property="og:description" content="The function fits the SFO, IORE and DFOP models using mmkin and returns an object of class nafta that has methods for printing and plotting. Print nafta objects. The results for the three models are printed in the -order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,174 +62,162 @@ order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Evaluate parent kinetics using the NAFTA guidance</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nafta.R'><code>R/nafta.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nafta.R" class="external-link"><code>R/nafta.R</code></a></small> <div class="hidden name"><code>nafta.Rd</code></div> </div> <div class="ref-description"> - <p>The function fits the SFO, IORE and DFOP models using <code><a href='mmkin.html'>mmkin</a></code> + <p>The function fits the SFO, IORE and DFOP models using <code><a href="mmkin.html">mmkin</a></code> and returns an object of class <code>nafta</code> that has methods for printing and plotting.</p> <p>Print nafta objects. The results for the three models are printed in the order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP.</p> </div> - <pre class="usage"><span class='fu'>nafta</span><span class='op'>(</span><span class='va'>ds</span>, title <span class='op'>=</span> <span class='cn'>NA</span>, quiet <span class='op'>=</span> <span class='cn'>FALSE</span>, <span class='va'>...</span><span class='op'>)</span> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">nafta</span><span class="op">(</span><span class="va">ds</span>, title <span class="op">=</span> <span class="cn">NA</span>, quiet <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span> -<span class='co'># S3 method for nafta</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, digits <span class='op'>=</span> <span class='fl'>3</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>ds</th> - <td><p>A dataframe that must contain one variable called "time" with the -time values specified by the <code>time</code> argument, one column called -"name" with the grouping of the observed values, and finally one column of -observed values called "value".</p></td> - </tr> - <tr> - <th>title</th> - <td><p>Optional title of the dataset</p></td> - </tr> - <tr> - <th>quiet</th> - <td><p>Should the evaluation text be shown?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to <code><a href='mmkin.html'>mmkin</a></code> (not for the -printing method).</p></td> - </tr> - <tr> - <th>x</th> - <td><p>An <code>nafta</code> object.</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>Number of digits to be used for printing parameters and -dissipation times.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> +<span class="co"># S3 method for nafta</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, digits <span class="op">=</span> <span class="fl">3</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="source"> + <h2>Source</h2> <p>NAFTA (2011) Guidance for evaluating and calculating degradation kinetics in environmental media. NAFTA Technical Working Group on Pesticides -<a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> +<a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> accessed 2019-02-22</p> <p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-life Values and Characterizing Pesticide Degradation -<a href='https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance'>https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +<a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>ds</dt> +<dd><p>A dataframe that must contain one variable called "time" with the +time values specified by the <code>time</code> argument, one column called +"name" with the grouping of the observed values, and finally one column of +observed values called "value".</p></dd> +<dt>title</dt> +<dd><p>Optional title of the dataset</p></dd> +<dt>quiet</dt> +<dd><p>Should the evaluation text be shown?</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to <code><a href="mmkin.html">mmkin</a></code> (not for the +printing method).</p></dd> +<dt>x</dt> +<dd><p>An <code>nafta</code> object.</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to be used for printing parameters and +dissipation times.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>An list of class <code>nafta</code>. The list element named "mmkin" is the -<code><a href='mmkin.html'>mmkin</a></code> object containing the fits of the three models. The +<code><a href="mmkin.html">mmkin</a></code> object containing the fits of the three models. The list element named "title" contains the title of the dataset used. The list element "data" contains the dataset used in the fits.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='va'>nafta_evaluation</span> <span class='op'><-</span> <span class='fu'>nafta</span><span class='op'>(</span><span class='va'>NAFTA_SOP_Appendix_D</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></div><div class='output co'>#> <span class='message'>The representative half-life of the IORE model is longer than the one corresponding</span></div><div class='output co'>#> <span class='message'>to the terminal degradation rate found with the DFOP model.</span></div><div class='output co'>#> <span class='message'>The representative half-life obtained from the DFOP model may be used</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>nafta_evaluation</span><span class='op'>)</span> -</div><div class='output co'>#> Sums of squares: -#> SFO IORE DFOP -#> 1378.6832 615.7730 517.8836 -#> -#> Critical sum of squares for checking the SFO model: -#> [1] 717.4598 -#> -#> Parameters: -#> $SFO -#> Estimate Pr(>t) Lower Upper -#> parent_0 83.7558 1.80e-14 77.18268 90.3288 -#> k_parent 0.0017 7.43e-05 0.00112 0.0026 -#> sigma 8.7518 1.22e-05 5.64278 11.8608 -#> -#> $IORE -#> Estimate Pr(>t) Lower Upper -#> parent_0 9.69e+01 NA 8.88e+01 1.05e+02 -#> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09 -#> N_parent 6.68e+00 NA 4.19e+00 9.17e+00 -#> sigma 5.85e+00 NA 3.76e+00 7.94e+00 -#> -#> $DFOP -#> Estimate Pr(>t) Lower Upper -#> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02 -#> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02 -#> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03 -#> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01 -#> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00 -#> -#> -#> DTx values: -#> DT50 DT90 DT50_rep -#> SFO 407 1350 407 -#> IORE 541 5190000 1560000 -#> DFOP 429 2380 841 -#> -#> Representative half-life: -#> [1] 841.41</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>nafta_evaluation</span><span class='op'>)</span> -</div><div class='img'><img src='nafta-1.png' alt='' width='700' height='433' /></div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="va">nafta_evaluation</span> <span class="op"><-</span> <span class="fu">nafta</span><span class="op">(</span><span class="va">NAFTA_SOP_Appendix_D</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> +<span class="r-msg co"><span class="r-pr">#></span> The representative half-life of the IORE model is longer than the one corresponding</span> +<span class="r-msg co"><span class="r-pr">#></span> to the terminal degradation rate found with the DFOP model.</span> +<span class="r-msg co"><span class="r-pr">#></span> The representative half-life obtained from the DFOP model may be used</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> +<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> +<span class="r-out co"><span class="r-pr">#></span> 1378.6832 615.7730 517.8836 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 717.4598</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 83.7558 1.80e-14 77.18268 90.3288</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0017 7.43e-05 0.00112 0.0026</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 8.7518 1.22e-05 5.64278 11.8608</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $IORE</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 9.69e+01 NA 8.88e+01 1.05e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09</span> +<span class="r-out co"><span class="r-pr">#></span> N_parent 6.68e+00 NA 4.19e+00 9.17e+00</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.85e+00 NA 3.76e+00 7.94e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03</span> +<span class="r-out co"><span class="r-pr">#></span> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> +<span class="r-out co"><span class="r-pr">#></span> SFO 407 1350 407</span> +<span class="r-out co"><span class="r-pr">#></span> IORE 541 5190000 1560000</span> +<span class="r-out co"><span class="r-pr">#></span> DFOP 429 2380 841</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] 841.41</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nafta-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with 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An mmkin row object is essentially a list of mkinfit objects that have been obtained by fitting the same model to a list of -datasets. They are used internally by the nlme.mmkin() method." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +datasets. They are used internally by the nlme.mmkin() method."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ datasets. They are used internally by the nlme.mmkin() method." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ datasets. They are used internally by the nlme.mmkin() method." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ datasets. They are used internally by the nlme.mmkin() method." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,34 +61,27 @@ datasets. They are used internally by the nlme.mmkin() method." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Helper functions to create nlme models from mmkin row objects</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nlme.R'><code>R/nlme.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.R" class="external-link"><code>R/nlme.R</code></a></small> <div class="hidden name"><code>nlme.Rd</code></div> </div> @@ -150,137 +89,128 @@ datasets. They are used internally by the nlme.mmkin() method." /> <p>These functions facilitate setting up a nonlinear mixed effects model for an mmkin row object. An mmkin row object is essentially a list of mkinfit objects that have been obtained by fitting the same model to a list of -datasets. They are used internally by the <code><a href='nlme.mmkin.html'>nlme.mmkin()</a></code> method.</p> +datasets. They are used internally by the <code><a href="nlme.mmkin.html">nlme.mmkin()</a></code> method.</p> </div> - <pre class="usage"><span class='fu'>nlme_function</span><span class='op'>(</span><span class='va'>object</span><span class='op'>)</span> - -<span class='fu'>mean_degparms</span><span class='op'>(</span><span class='va'>object</span>, random <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> - -<span class='fu'>nlme_data</span><span class='op'>(</span><span class='va'>object</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An mmkin row object containing several fits of the same model to different datasets</p></td> - </tr> - <tr> - <th>random</th> - <td><p>Should a list with fixed and random effects be returned?</p></td> - </tr> - </table> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">nlme_function</span><span class="op">(</span><span class="va">object</span><span class="op">)</span> - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - - <p>A function that can be used with nlme</p> -<p>If random is FALSE (default), a named vector containing mean values -of the fitted degradation model parameters. If random is TRUE, a list with -fixed and random effects, in the format required by the start argument of -nlme for the case of a single grouping variable ds.</p> -<p>A <code><a href='https://rdrr.io/pkg/nlme/man/groupedData.html'>groupedData</a></code> object</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><code><a href='nlme.mmkin.html'>nlme.mmkin</a></code></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> -<span class='va'>m_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> -<span class='va'>d_SFO_1</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.1</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>98</span><span class='op'>)</span>, <span class='va'>sampling_times</span><span class='op'>)</span> -<span class='va'>d_SFO_1_long</span> <span class='op'><-</span> <span class='fu'><a href='mkin_wide_to_long.html'>mkin_wide_to_long</a></span><span class='op'>(</span><span class='va'>d_SFO_1</span>, time <span class='op'>=</span> <span class='st'>"time"</span><span class='op'>)</span> -<span class='va'>d_SFO_2</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.05</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>102</span><span class='op'>)</span>, <span class='va'>sampling_times</span><span class='op'>)</span> -<span class='va'>d_SFO_2_long</span> <span class='op'><-</span> <span class='fu'><a href='mkin_wide_to_long.html'>mkin_wide_to_long</a></span><span class='op'>(</span><span class='va'>d_SFO_2</span>, time <span class='op'>=</span> <span class='st'>"time"</span><span class='op'>)</span> -<span class='va'>d_SFO_3</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.02</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>103</span><span class='op'>)</span>, <span class='va'>sampling_times</span><span class='op'>)</span> -<span class='va'>d_SFO_3_long</span> <span class='op'><-</span> <span class='fu'><a href='mkin_wide_to_long.html'>mkin_wide_to_long</a></span><span class='op'>(</span><span class='va'>d_SFO_3</span>, time <span class='op'>=</span> <span class='st'>"time"</span><span class='op'>)</span> - -<span class='va'>d1</span> <span class='op'><-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_SFO_1</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fl'>3</span>, n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -<span class='va'>d2</span> <span class='op'><-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_SFO_2</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fl'>2</span>, n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -<span class='va'>d3</span> <span class='op'><-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_SFO_3</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fl'>4</span>, n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -<span class='va'>ds</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>d1 <span class='op'>=</span> <span class='va'>d1</span>, d2 <span class='op'>=</span> <span class='va'>d2</span>, d3 <span class='op'>=</span> <span class='va'>d3</span><span class='op'>)</span> +<span class="fu">nlme_data</span><span class="op">(</span><span class="va">object</span><span class="op">)</span></code></pre></div> + </div> -<span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>ds</span>, cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>mean_dp</span> <span class='op'><-</span> <span class='fu'>mean_degparms</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -<span class='va'>grouped_data</span> <span class='op'><-</span> <span class='fu'>nlme_data</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -<span class='va'>nlme_f</span> <span class='op'><-</span> <span class='fu'>nlme_function</span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -<span class='co'># These assignments are necessary for these objects to be</span> -<span class='co'># visible to nlme and augPred when evaluation is done by</span> -<span class='co'># pkgdown to generated the html docs.</span> -<span class='fu'><a href='https://rdrr.io/r/base/assign.html'>assign</a></span><span class='op'>(</span><span class='st'>"nlme_f"</span>, <span class='va'>nlme_f</span>, <span class='fu'><a href='https://rdrr.io/r/base/environment.html'>globalenv</a></span><span class='op'>(</span><span class='op'>)</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/assign.html'>assign</a></span><span class='op'>(</span><span class='st'>"grouped_data"</span>, <span class='va'>grouped_data</span>, <span class='fu'><a href='https://rdrr.io/r/base/environment.html'>globalenv</a></span><span class='op'>(</span><span class='op'>)</span><span class='op'>)</span> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An mmkin row object containing several fits of the same model to different datasets</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>A function that can be used with nlme +A <code><a href="https://rdrr.io/pkg/nlme/man/groupedData.html" class="external-link">groupedData</a></code> object</p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><code><a href="nlme.mmkin.html">nlme.mmkin</a></code></p></div> + </div> -<span class='kw'><a href='https://rdrr.io/r/base/library.html'>library</a></span><span class='op'>(</span><span class='va'><a href='https://svn.r-project.org/R-packages/trunk/nlme/'>nlme</a></span><span class='op'>)</span> -<span class='va'>m_nlme</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>value</span> <span class='op'>~</span> <span class='fu'>nlme_f</span><span class='op'>(</span><span class='va'>name</span>, <span class='va'>time</span>, <span class='va'>parent_0</span>, <span class='va'>log_k_parent_sink</span><span class='op'>)</span>, - data <span class='op'>=</span> <span class='va'>grouped_data</span>, - fixed <span class='op'>=</span> <span class='va'>parent_0</span> <span class='op'>+</span> <span class='va'>log_k_parent_sink</span> <span class='op'>~</span> <span class='fl'>1</span>, - random <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/pdDiag.html'>pdDiag</a></span><span class='op'>(</span><span class='va'>parent_0</span> <span class='op'>+</span> <span class='va'>log_k_parent_sink</span> <span class='op'>~</span> <span class='fl'>1</span><span class='op'>)</span>, - start <span class='op'>=</span> <span class='va'>mean_dp</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>m_nlme</span><span class='op'>)</span> -</div><div class='output co'>#> Nonlinear mixed-effects model fit by maximum likelihood -#> Model: value ~ nlme_f(name, time, parent_0, log_k_parent_sink) -#> Data: grouped_data -#> AIC BIC logLik -#> 300.6824 310.2426 -145.3412 -#> -#> Random effects: -#> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1) -#> Level: ds -#> Structure: Diagonal -#> parent_0 log_k_parent_sink Residual -#> StdDev: 1.697361 0.6801209 3.666073 -#> -#> Fixed effects: parent_0 + log_k_parent_sink ~ 1 -#> Value Std.Error DF t-value p-value -#> parent_0 100.99378 1.3890416 46 72.70753 0 -#> log_k_parent_sink -3.07521 0.4018589 46 -7.65246 0 -#> Correlation: -#> prnt_0 -#> log_k_parent_sink 0.027 -#> -#> Standardized Within-Group Residuals: -#> Min Q1 Med Q3 Max -#> -1.9942823 -0.5622565 0.1791579 0.7165038 2.0704781 -#> -#> Number of Observations: 50 -#> Number of Groups: 3 </div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/pkg/nlme/man/augPred.html'>augPred</a></span><span class='op'>(</span><span class='va'>m_nlme</span>, level <span class='op'>=</span> <span class='fl'>0</span><span class='op'>:</span><span class='fl'>1</span><span class='op'>)</span>, layout <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fl'>1</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='nlme-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># augPred does not work on fits with more than one state</span> -<span class='co'># variable</span> -<span class='co'>#</span> -<span class='co'># The procedure is greatly simplified by the nlme.mmkin function</span> -<span class='va'>f_nlme</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_nlme</span><span class='op'>)</span> -</div><div class='img'><img src='nlme-2.png' alt='' width='700' height='433' /></div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">m_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">98</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_1_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_1</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">102</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_2_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_2</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_3</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">103</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_SFO_3_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_3</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d1</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_1</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">3</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d2</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_2</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">2</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d3</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_3</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">4</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>d1 <span class="op">=</span> <span class="va">d1</span>, d2 <span class="op">=</span> <span class="va">d2</span>, d3 <span class="op">=</span> <span class="va">d3</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">ds</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">mean_dp</span> <span class="op"><-</span> <span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-in"><span class="va">grouped_data</span> <span class="op"><-</span> <span class="fu">nlme_data</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-in"><span class="va">nlme_f</span> <span class="op"><-</span> <span class="fu">nlme_function</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># These assignments are necessary for these objects to be</span></span> +<span class="r-in"><span class="co"># visible to nlme and augPred when evaluation is done by</span></span> +<span class="r-in"><span class="co"># pkgdown to generate the html docs.</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="st">"nlme_f"</span>, <span class="va">nlme_f</span>, <span class="fu"><a href="https://rdrr.io/r/base/environment.html" class="external-link">globalenv</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="st">"grouped_data"</span>, <span class="va">grouped_data</span>, <span class="fu"><a href="https://rdrr.io/r/base/environment.html" class="external-link">globalenv</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span> +<span class="r-in"><span class="va">m_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu">nlme_f</span><span class="op">(</span><span class="va">name</span>, <span class="va">time</span>, <span class="va">parent_0</span>, <span class="va">log_k_parent_sink</span><span class="op">)</span>,</span> +<span class="r-in"> data <span class="op">=</span> <span class="va">grouped_data</span>,</span> +<span class="r-in"> fixed <span class="op">=</span> <span class="va">parent_0</span> <span class="op">+</span> <span class="va">log_k_parent_sink</span> <span class="op">~</span> <span class="fl">1</span>,</span> +<span class="r-in"> random <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">pdDiag</a></span><span class="op">(</span><span class="va">parent_0</span> <span class="op">+</span> <span class="va">log_k_parent_sink</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span>,</span> +<span class="r-in"> start <span class="op">=</span> <span class="va">mean_dp</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m_nlme</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Nonlinear mixed-effects model fit by maximum likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> Model: value ~ nlme_f(name, time, parent_0, log_k_parent_sink) </span> +<span class="r-out co"><span class="r-pr">#></span> Data: grouped_data </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 300.6824 310.2426 -145.3412</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1)</span> +<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink Residual</span> +<span class="r-out co"><span class="r-pr">#></span> StdDev: 1.697361 0.6801209 3.666073</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed effects: parent_0 + log_k_parent_sink ~ 1 </span> +<span class="r-out co"><span class="r-pr">#></span> Value Std.Error DF t-value p-value</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 100.99378 1.3890416 46 72.70753 0</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink -3.07521 0.4018589 46 -7.65246 0</span> +<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> +<span class="r-out co"><span class="r-pr">#></span> prnt_0</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink 0.027 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Standardized Within-Group Residuals:</span> +<span class="r-out co"><span class="r-pr">#></span> Min Q1 Med Q3 Max </span> +<span class="r-out co"><span class="r-pr">#></span> -1.9942823 -0.5622565 0.1791579 0.7165038 2.0704781 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Number of Observations: 50</span> +<span class="r-out co"><span class="r-pr">#></span> Number of Groups: 3 </span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/augPred.html" class="external-link">augPred</a></span><span class="op">(</span><span class="va">m_nlme</span>, level <span class="op">=</span> <span class="fl">0</span><span class="op">:</span><span class="fl">1</span><span class="op">)</span>, layout <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fl">1</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlme-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># augPred does not work on fits with more than one state</span></span> +<span class="r-in"><span class="co"># variable</span></span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="co"># The procedure is greatly simplified by the nlme.mmkin function</span></span> +<span class="r-in"><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlme-2.png" alt="" width="700" height="433"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/nlme.mmkin-1.png b/docs/reference/nlme.mmkin-1.png Binary files differindex 95adfafb..d93b0950 100644 --- a/docs/reference/nlme.mmkin-1.png +++ b/docs/reference/nlme.mmkin-1.png diff --git a/docs/reference/nlme.mmkin-2.png b/docs/reference/nlme.mmkin-2.png Binary files differindex 53b6fc76..5afccfbb 100644 --- a/docs/reference/nlme.mmkin-2.png +++ b/docs/reference/nlme.mmkin-2.png diff --git a/docs/reference/nlme.mmkin-3.png b/docs/reference/nlme.mmkin-3.png Binary files differindex e87d15e5..bf3aac6c 100644 --- a/docs/reference/nlme.mmkin-3.png +++ b/docs/reference/nlme.mmkin-3.png diff --git a/docs/reference/nlme.mmkin.html b/docs/reference/nlme.mmkin.html index b3052605..56770856 100644 --- a/docs/reference/nlme.mmkin.html +++ b/docs/reference/nlme.mmkin.html @@ -1,69 +1,14 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Create an nlme model for an mmkin row object — nlme.mmkin • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link 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http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Create an nlme model for an mmkin row object — nlme.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script 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An mmkin row object is essentially a list of mkinfit objects that -have been obtained by fitting the same model to a list of datasets." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +have been obtained by fitting the same model to a list of datasets."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ have been obtained by fitting the same model to a list of datasets." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ have been obtained by fitting the same model to a list of datasets." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ have been obtained by fitting the same model to a list of datasets." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,34 +60,27 @@ have been obtained by fitting the same model to a list of datasets." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Create an nlme model for an mmkin row object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nlme.mmkin.R'><code>R/nlme.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.mmkin.R" class="external-link"><code>R/nlme.mmkin.R</code></a></small> <div class="hidden name"><code>nlme.mmkin.Rd</code></div> </div> @@ -151,339 +90,316 @@ object. An mmkin row object is essentially a list of mkinfit objects that have been obtained by fitting the same model to a list of datasets.</p> </div> - <pre class="usage"><span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span> - <span class='va'>model</span>, - data <span class='op'>=</span> <span class='st'>"auto"</span>, - fixed <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>as.list</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='fu'><a href='nlme_function.html'>mean_degparms</a></span><span class='op'>(</span><span class='va'>model</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>el</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/eval.html'>eval</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/parse.html'>parse</a></span><span class='op'>(</span>text <span class='op'>=</span> - <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='va'>el</span>, <span class='fl'>1</span>, sep <span class='op'>=</span> <span class='st'>"~"</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span>, - random <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/pdDiag.html'>pdDiag</a></span><span class='op'>(</span><span class='va'>fixed</span><span class='op'>)</span>, - <span class='va'>groups</span>, - start <span class='op'>=</span> <span class='fu'><a href='nlme_function.html'>mean_degparms</a></span><span class='op'>(</span><span class='va'>model</span>, random <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - correlation <span class='op'>=</span> <span class='cn'>NULL</span>, - weights <span class='op'>=</span> <span class='cn'>NULL</span>, - <span class='va'>subset</span>, - method <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"ML"</span>, <span class='st'>"REML"</span><span class='op'>)</span>, - na.action <span class='op'>=</span> <span class='va'>na.fail</span>, - <span class='va'>naPattern</span>, - control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='op'>)</span>, - verbose <span class='op'>=</span> <span class='cn'>FALSE</span> -<span class='op'>)</span> - -<span class='co'># S3 method for nlme.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for nlme.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>model</th> - <td><p>An <a href='mmkin.html'>mmkin</a> row object.</p></td> - </tr> - <tr> - <th>data</th> - <td><p>Ignored, data are taken from the mmkin model</p></td> - </tr> - <tr> - <th>fixed</th> - <td><p>Ignored, all degradation parameters fitted in the -mmkin model are used as fixed parameters</p></td> - </tr> - <tr> - <th>random</th> - <td><p>If not specified, correlated random effects are set up -for all optimised degradation model parameters using the log-Cholesky -parameterization <a href='https://rdrr.io/pkg/nlme/man/pdLogChol.html'>nlme::pdLogChol</a> that is also the default of -the generic <a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a> method.</p></td> - </tr> - <tr> - <th>groups</th> - <td><p>See the documentation of nlme</p></td> - </tr> - <tr> - <th>start</th> - <td><p>If not specified, mean values of the fitted degradation -parameters taken from the mmkin object are used</p></td> - </tr> - <tr> - <th>correlation</th> - <td><p>See the documentation of nlme</p></td> - </tr> - <tr> - <th>weights</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>subset</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>method</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>na.action</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>naPattern</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>control</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>verbose</th> - <td><p>passed to nlme</p></td> - </tr> - <tr> - <th>x</th> - <td><p>An nlme.mmkin object to print</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>Number of digits to use for printing</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Update specifications passed to update.nlme</p></td> - </tr> - <tr> - <th>object</th> - <td><p>An nlme.mmkin object to update</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span> + <span class="va">model</span>, + data <span class="op">=</span> <span class="st">"auto"</span>, + fixed <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">as.list</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">model</span><span class="op">)</span><span class="op">)</span><span class="op">)</span>, <span class="kw">function</span><span class="op">(</span><span class="va">el</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/eval.html" class="external-link">eval</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/parse.html" class="external-link">parse</a></span><span class="op">(</span>text <span class="op">=</span> + <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="va">el</span>, <span class="fl">1</span>, sep <span class="op">=</span> <span class="st">"~"</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">)</span>, + random <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">pdDiag</a></span><span class="op">(</span><span class="va">fixed</span><span class="op">)</span>, + <span class="va">groups</span>, + start <span class="op">=</span> <span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">model</span>, random <span class="op">=</span> <span class="cn">TRUE</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>, + correlation <span class="op">=</span> <span class="cn">NULL</span>, + weights <span class="op">=</span> <span class="cn">NULL</span>, + <span class="va">subset</span>, + method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"ML"</span>, <span class="st">"REML"</span><span class="op">)</span>, + na.action <span class="op">=</span> <span class="va">na.fail</span>, + <span class="va">naPattern</span>, + control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="op">)</span>, + verbose <span class="op">=</span> <span class="cn">FALSE</span> +<span class="op">)</span> + +<span class="co"># S3 method for nlme.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for nlme.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>model</dt> +<dd><p>An <a href="mmkin.html">mmkin</a> row object.</p></dd> +<dt>data</dt> +<dd><p>Ignored, data are taken from the mmkin model</p></dd> +<dt>fixed</dt> +<dd><p>Ignored, all degradation parameters fitted in the +mmkin model are used as fixed parameters</p></dd> +<dt>random</dt> +<dd><p>If not specified, no correlations between random effects are +set up for the optimised degradation model parameters. This is +achieved by using the <a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">nlme::pdDiag</a> method.</p></dd> +<dt>groups</dt> +<dd><p>See the documentation of nlme</p></dd> +<dt>start</dt> +<dd><p>If not specified, mean values of the fitted degradation +parameters taken from the mmkin object are used</p></dd> +<dt>correlation</dt> +<dd><p>See the documentation of nlme</p></dd> +<dt>weights</dt> +<dd><p>passed to nlme</p></dd> +<dt>subset</dt> +<dd><p>passed to nlme</p></dd> +<dt>method</dt> +<dd><p>passed to nlme</p></dd> +<dt>na.action</dt> +<dd><p>passed to nlme</p></dd> +<dt>naPattern</dt> +<dd><p>passed to nlme</p></dd> +<dt>control</dt> +<dd><p>passed to nlme</p></dd> +<dt>verbose</dt> +<dd><p>passed to nlme</p></dd> +<dt>x</dt> +<dd><p>An nlme.mmkin object to print</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +<dt>...</dt> +<dd><p>Update specifications passed to update.nlme</p></dd> +<dt>object</dt> +<dd><p>An nlme.mmkin object to update</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>Upon success, a fitted 'nlme.mmkin' object, which is an nlme object with additional elements. It also inherits from 'mixed.mmkin'.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>Note that the convergence of the nlme algorithms depends on the quality of the data. In degradation kinetics, we often only have few datasets (e.g. data for few soils) and complicated degradation models, which may make it impossible to obtain convergence with nlme.</p> - <h2 class="hasAnchor" id="note"><a class="anchor" href="#note"></a>Note</h2> - - <p>As the object inherits from <a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme::nlme</a>, there is a wealth of + </div> + <div id="note"> + <h2>Note</h2> + <p>As the object inherits from <a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme::nlme</a>, there is a wealth of methods that will automatically work on 'nlme.mmkin' objects, such as -<code><a href='https://rdrr.io/pkg/nlme/man/intervals.html'>nlme::intervals()</a></code>, <code><a href='https://rdrr.io/pkg/nlme/man/anova.lme.html'>nlme::anova.lme()</a></code> and <code><a href='https://rdrr.io/pkg/nlme/man/coef.lme.html'>nlme::coef.lme()</a></code>.</p> - <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2> - - <div class='dont-index'><p><code><a href='nlme_function.html'>nlme_function()</a></code>, <a href='plot.mixed.mmkin.html'>plot.mixed.mmkin</a>, <a href='summary.nlme.mmkin.html'>summary.nlme.mmkin</a></p></div> - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>ds</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>]</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span><span class='op'>)</span><span class='op'>]</span>, <span class='va'>name</span> <span class='op'>==</span> <span class='st'>"parent"</span><span class='op'>)</span><span class='op'>)</span> -<span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, <span class='va'>ds</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -<span class='kw'><a href='https://rdrr.io/r/base/library.html'>library</a></span><span class='op'>(</span><span class='va'><a href='https://svn.r-project.org/R-packages/trunk/nlme/'>nlme</a></span><span class='op'>)</span> -<span class='va'>f_nlme_sfo</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span><span class='st'>"SFO"</span>, <span class='op'>]</span><span class='op'>)</span> - -<span class='co'># \dontrun{</span> - - <span class='va'>f_nlme_dfop</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span><span class='st'>"DFOP"</span>, <span class='op'>]</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/stats/anova.html'>anova</a></span><span class='op'>(</span><span class='va'>f_nlme_sfo</span>, <span class='va'>f_nlme_dfop</span><span class='op'>)</span> -</div><div class='output co'>#> Model df AIC BIC logLik Test L.Ratio p-value -#> f_nlme_sfo 1 5 625.0539 637.5529 -307.5269 -#> f_nlme_dfop 2 9 495.1270 517.6253 -238.5635 1 vs 2 137.9269 <.0001</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop</span><span class='op'>)</span> -</div><div class='output co'>#> Kinetic nonlinear mixed-effects model fit by maximum likelihood -#> -#> Structural model: -#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -#> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -#> * parent -#> -#> Data: -#> 90 observations of 1 variable(s) grouped in 5 datasets -#> -#> Log-likelihood: -238.6 -#> -#> Fixed effects: -#> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) -#> parent_0 log_k1 log_k2 g_qlogis -#> 94.1702 -1.8002 -4.1474 0.0324 -#> -#> Random effects: -#> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) -#> Level: ds -#> Structure: Diagonal -#> parent_0 log_k1 log_k2 g_qlogis Residual -#> StdDev: 2.488 0.8447 1.33 0.4652 2.321 -#> </div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop</span><span class='op'>)</span> -</div><div class='img'><img src='nlme.mmkin-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop</span><span class='op'>)</span> -</div><div class='output co'>#> $distimes -#> DT50 DT90 DT50back DT50_k1 DT50_k2 -#> parent 10.79857 100.7937 30.34193 4.193938 43.85443 -#> </div><div class='input'> - <span class='va'>ds_2</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>]</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span><span class='op'>)</span><span class='op'>]</span><span class='op'>)</span> - <span class='va'>m_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"min"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>m_sfo_sfo_ff</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='va'>m_dfop_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - - <span class='va'>f_2</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"SFO-SFO"</span> <span class='op'>=</span> <span class='va'>m_sfo_sfo</span>, - <span class='st'>"SFO-SFO-ff"</span> <span class='op'>=</span> <span class='va'>m_sfo_sfo_ff</span>, - <span class='st'>"DFOP-SFO"</span> <span class='op'>=</span> <span class='va'>m_dfop_sfo</span><span class='op'>)</span>, - <span class='va'>ds_2</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - - <span class='va'>f_nlme_sfo_sfo</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_2</span><span class='op'>[</span><span class='st'>"SFO-SFO"</span>, <span class='op'>]</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_nlme_sfo_sfo</span><span class='op'>)</span> -</div><div class='img'><img src='nlme.mmkin-2.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='co'># With formation fractions this does not coverge with defaults</span> - <span class='co'># f_nlme_sfo_sfo_ff <- nlme(f_2["SFO-SFO-ff", ])</span> - <span class='co'>#plot(f_nlme_sfo_sfo_ff)</span> - - <span class='co'># For the following, we need to increase pnlsMaxIter and the tolerance</span> - <span class='co'># to get convergence</span> - <span class='va'>f_nlme_dfop_sfo</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_2</span><span class='op'>[</span><span class='st'>"DFOP-SFO"</span>, <span class='op'>]</span>, - control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>pnlsMaxIter <span class='op'>=</span> <span class='fl'>120</span>, tolerance <span class='op'>=</span> <span class='fl'>5e-4</span><span class='op'>)</span><span class='op'>)</span> - - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop_sfo</span><span class='op'>)</span> -</div><div class='img'><img src='nlme.mmkin-3.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/stats/anova.html'>anova</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop_sfo</span>, <span class='va'>f_nlme_sfo_sfo</span><span class='op'>)</span> -</div><div class='output co'>#> Model df AIC BIC logLik Test L.Ratio p-value -#> f_nlme_dfop_sfo 1 13 843.8548 884.6201 -408.9274 -#> f_nlme_sfo_sfo 2 9 1085.1821 1113.4043 -533.5910 1 vs 2 249.3273 <.0001</div><div class='input'> - <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>f_nlme_sfo_sfo</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_sink parent_A1 A1_sink -#> 0.5912432 0.4087568 1.0000000 -#> -#> $distimes -#> DT50 DT90 -#> parent 19.13518 63.5657 -#> A1 66.02155 219.3189 -#> </div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop_sfo</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_A1 parent_sink -#> 0.2768575 0.7231425 -#> -#> $distimes -#> DT50 DT90 DT50back DT50_k1 DT50_k2 -#> parent 11.07091 104.6320 31.49737 4.462384 46.20825 -#> A1 162.30492 539.1653 NA NA NA -#> </div><div class='input'> - <span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='fu'>findFunction</span><span class='op'>(</span><span class='st'>"varConstProp"</span><span class='op'>)</span><span class='op'>)</span> <span class='op'>></span> <span class='fl'>0</span><span class='op'>)</span> <span class='op'>{</span> <span class='co'># tc error model for nlme available</span> - <span class='co'># Attempts to fit metabolite kinetics with the tc error model are possible,</span> - <span class='co'># but need tweeking of control values and sometimes do not converge</span> - - <span class='va'>f_tc</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, <span class='va'>ds</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> - <span class='va'>f_nlme_sfo_tc</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_tc</span><span class='op'>[</span><span class='st'>"SFO"</span>, <span class='op'>]</span><span class='op'>)</span> - <span class='va'>f_nlme_dfop_tc</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_tc</span><span class='op'>[</span><span class='st'>"DFOP"</span>, <span class='op'>]</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f_nlme_sfo</span>, <span class='va'>f_nlme_sfo_tc</span>, <span class='va'>f_nlme_dfop</span>, <span class='va'>f_nlme_dfop_tc</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop_tc</span><span class='op'>)</span> - <span class='op'>}</span> -</div><div class='output co'>#> Kinetic nonlinear mixed-effects model fit by maximum likelihood -#> -#> Structural model: -#> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * -#> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) -#> * parent -#> -#> Data: -#> 90 observations of 1 variable(s) grouped in 5 datasets -#> -#> Log-likelihood: -238.4 -#> -#> Fixed effects: -#> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) -#> parent_0 log_k1 log_k2 g_qlogis -#> 94.04774 -1.82340 -4.16716 0.05686 -#> -#> Random effects: -#> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) -#> Level: ds -#> Structure: Diagonal -#> parent_0 log_k1 log_k2 g_qlogis Residual -#> StdDev: 2.474 0.85 1.337 0.4659 1 -#> -#> Variance function: -#> Structure: Constant plus proportion of variance covariate -#> Formula: ~fitted(.) -#> Parameter estimates: -#> const prop -#> 2.23223147 0.01262395 </div><div class='input'> - <span class='va'>f_2_obs</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_2</span>, error_model <span class='op'>=</span> <span class='st'>"obs"</span><span class='op'>)</span> - <span class='va'>f_nlme_sfo_sfo_obs</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_2_obs</span><span class='op'>[</span><span class='st'>"SFO-SFO"</span>, <span class='op'>]</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>f_nlme_sfo_sfo_obs</span><span class='op'>)</span> -</div><div class='output co'>#> Kinetic nonlinear mixed-effects model fit by maximum likelihood -#> -#> Structural model: -#> d_parent/dt = - k_parent_sink * parent - k_parent_A1 * parent -#> d_A1/dt = + k_parent_A1 * parent - k_A1_sink * A1 -#> -#> Data: -#> 170 observations of 2 variable(s) grouped in 5 datasets -#> -#> Log-likelihood: -473 -#> -#> Fixed effects: -#> list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1) -#> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink -#> 87.976 -3.670 -4.164 -4.645 -#> -#> Random effects: -#> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1) -#> Level: ds -#> Structure: Diagonal -#> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink Residual -#> StdDev: 3.992 1.777 1.055 0.4821 6.483 -#> -#> Variance function: -#> Structure: Different standard deviations per stratum -#> Formula: ~1 | name -#> Parameter estimates: -#> parent A1 -#> 1.0000000 0.2049995 </div><div class='input'> <span class='va'>f_nlme_dfop_sfo_obs</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_2_obs</span><span class='op'>[</span><span class='st'>"DFOP-SFO"</span>, <span class='op'>]</span>, - control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>pnlsMaxIter <span class='op'>=</span> <span class='fl'>120</span>, tolerance <span class='op'>=</span> <span class='fl'>5e-4</span><span class='op'>)</span><span class='op'>)</span> - - <span class='va'>f_2_tc</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_2</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> - <span class='co'># f_nlme_sfo_sfo_tc <- nlme(f_2_tc["SFO-SFO", ]) # No convergence with 50 iterations</span> - <span class='co'># f_nlme_dfop_sfo_tc <- nlme(f_2_tc["DFOP-SFO", ],</span> - <span class='co'># control = list(pnlsMaxIter = 120, tolerance = 5e-4)) # Error in X[, fmap[[nm]]] <- gradnm</span> +<code><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">nlme::intervals()</a></code>, <code><a href="https://rdrr.io/pkg/nlme/man/anova.lme.html" class="external-link">nlme::anova.lme()</a></code> and <code><a href="https://rdrr.io/pkg/nlme/man/coef.lme.html" class="external-link">nlme::coef.lme()</a></code>.</p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><code><a href="nlme.html">nlme_function()</a></code>, <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a>, <a href="summary.nlme.mmkin.html">summary.nlme.mmkin</a></p></div> + </div> - <span class='fu'><a href='https://rdrr.io/r/stats/anova.html'>anova</a></span><span class='op'>(</span><span class='va'>f_nlme_dfop_sfo</span>, <span class='va'>f_nlme_dfop_sfo_obs</span><span class='op'>)</span> -</div><div class='output co'>#> Model df AIC BIC logLik Test L.Ratio -#> f_nlme_dfop_sfo 1 13 843.8548 884.6201 -408.9274 -#> f_nlme_dfop_sfo_obs 2 14 817.5338 861.4350 -394.7669 1 vs 2 28.32093 -#> p-value -#> f_nlme_dfop_sfo -#> f_nlme_dfop_sfo_obs <.0001</div><div class='input'> -<span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_nlme_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_nlme_dfop</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_sfo</span>, <span class="va">f_nlme_dfop</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio p-value</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_sfo 1 5 625.0539 637.5529 -307.5269 </span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop 2 9 495.1270 517.6253 -238.5635 1 vs 2 137.9269 <.0001</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * parent</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -238.6</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> +<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) </span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> 94.1702 -1.8002 -4.1474 0.0324 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)</span> +<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis Residual</span> +<span class="r-out co"><span class="r-pr">#></span> StdDev: 2.488 0.8447 1.33 0.4652 2.321</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlme.mmkin-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="r-out co"><span class="r-pr">#></span> parent 10.79857 100.7937 30.34193 4.193938 43.85443</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">ds_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">m_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"min"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">m_sfo_sfo_ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">m_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_2</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">m_sfo_sfo</span>,</span> +<span class="r-in"> <span class="st">"SFO-SFO-ff"</span> <span class="op">=</span> <span class="va">m_sfo_sfo_ff</span>,</span> +<span class="r-in"> <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">m_dfop_sfo</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">ds_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_nlme_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlme.mmkin-2.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># With formation fractions this does not coverge with defaults</span></span> +<span class="r-in"> <span class="co"># f_nlme_sfo_sfo_ff <- nlme(f_2["SFO-SFO-ff", ])</span></span> +<span class="r-in"> <span class="co">#plot(f_nlme_sfo_sfo_ff)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># For the following, we need to increase pnlsMaxIter and the tolerance</span></span> +<span class="r-in"> <span class="co"># to get convergence</span></span> +<span class="r-in"> <span class="va">f_nlme_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">5e-4</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlme.mmkin-3.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span>, <span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio p-value</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274 </span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_sfo_sfo 2 9 1085.1821 1113.4043 -533.5910 1 vs 2 249.3274 <.0001</span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_sink parent_A1 A1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 0.5912432 0.4087568 1.0000000 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 19.13518 63.5657</span> +<span class="r-out co"><span class="r-pr">#></span> A1 66.02155 219.3189</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_A1 parent_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 0.2768574 0.7231426 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> +<span class="r-out co"><span class="r-pr">#></span> parent 11.07091 104.6320 31.49737 4.462383 46.20825</span> +<span class="r-out co"><span class="r-pr">#></span> A1 162.30519 539.1662 NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"></span> +<span class="r-in"> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="fu">findFunction</span><span class="op">(</span><span class="st">"varConstProp"</span><span class="op">)</span><span class="op">)</span> <span class="op">></span> <span class="fl">0</span><span class="op">)</span> <span class="op">{</span> <span class="co"># tc error model for nlme available</span></span> +<span class="r-in"> <span class="co"># Attempts to fit metabolite kinetics with the tc error model are possible,</span></span> +<span class="r-in"> <span class="co"># but need tweeking of control values and sometimes do not converge</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_nlme_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_nlme_dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nlme_sfo</span>, <span class="va">f_nlme_sfo_tc</span>, <span class="va">f_nlme_dfop</span>, <span class="va">f_nlme_dfop_tc</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_dfop_tc</span><span class="op">)</span></span> +<span class="r-in"> <span class="op">}</span></span> +<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> +<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> +<span class="r-out co"><span class="r-pr">#></span> * parent</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -238.4</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> +<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) </span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis </span> +<span class="r-out co"><span class="r-pr">#></span> 94.04774 -1.82340 -4.16716 0.05686 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)</span> +<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis Residual</span> +<span class="r-out co"><span class="r-pr">#></span> StdDev: 2.474 0.85 1.337 0.4659 1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Constant plus proportion of variance covariate</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: ~fitted(.) </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> +<span class="r-out co"><span class="r-pr">#></span> const prop </span> +<span class="r-out co"><span class="r-pr">#></span> 2.23223147 0.01262395 </span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_2_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_2</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_nlme_sfo_sfo_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2_obs</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo_obs</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent_sink * parent - k_parent_A1 * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + k_parent_A1 * parent - k_A1_sink * A1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -473</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> +<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1) </span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 87.976 -3.670 -4.164 -4.645 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1)</span> +<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink Residual</span> +<span class="r-out co"><span class="r-pr">#></span> StdDev: 3.992 1.777 1.055 0.4821 6.483</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Different standard deviations per stratum</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: ~1 | name </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> +<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 1.0000000 0.2049995 </span> +<span class="r-in"> <span class="va">f_nlme_dfop_sfo_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">5e-4</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_2_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_2</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"> <span class="co"># f_nlme_sfo_sfo_tc <- nlme(f_2_tc["SFO-SFO", ]) # No convergence with 50 iterations</span></span> +<span class="r-in"> <span class="co"># f_nlme_dfop_sfo_tc <- nlme(f_2_tc["DFOP-SFO", ],</span></span> +<span class="r-in"> <span class="co"># control = list(pnlsMaxIter = 120, tolerance = 5e-4)) # Error in X[, fmap[[nm]]] <- gradnm</span></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span>, <span class="va">f_nlme_dfop_sfo_obs</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274 </span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo_obs 2 14 817.5338 861.4350 -394.7669 1 vs 2 28.32091</span> +<span class="r-out co"><span class="r-pr">#></span> p-value</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo </span> +<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo_obs <.0001</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> 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name"><code>nlmixr.mmkin.Rd</code></div> + </div> + + <div class="ref-description"> + <p>This function uses <code><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr()</a></code> as a backend for fitting nonlinear mixed +effects models created from <a href="mmkin.html">mmkin</a> row objects using the Stochastic Approximation +Expectation Maximisation algorithm (SAEM) or First Order Conditional +Estimation with Interaction (FOCEI).</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span> + <span class="va">object</span>, + data <span class="op">=</span> <span class="cn">NULL</span>, + est <span class="op">=</span> <span class="cn">NULL</span>, + control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="op">)</span>, + table <span class="op">=</span> <span class="fu">tableControl</span><span class="op">(</span><span class="op">)</span>, + error_model <span class="op">=</span> <span class="va">object</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">err_mod</span>, + test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>, + conf.level <span class="op">=</span> <span class="fl">0.6</span>, + degparms_start <span class="op">=</span> <span class="st">"auto"</span>, + eta_start <span class="op">=</span> <span class="st">"auto"</span>, + <span class="va">...</span>, + save <span class="op">=</span> <span class="cn">NULL</span>, + envir <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/sys.parent.html" class="external-link">parent.frame</a></span><span class="op">(</span><span class="op">)</span> +<span class="op">)</span> + +<span class="co"># S3 method for nlmixr.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span> + +<span class="fu">nlmixr_model</span><span class="op">(</span> + <span class="va">object</span>, + est <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"saem"</span>, <span class="st">"focei"</span><span class="op">)</span>, + degparms_start <span class="op">=</span> <span class="st">"auto"</span>, + eta_start <span class="op">=</span> <span class="st">"auto"</span>, + test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>, + conf.level <span class="op">=</span> <span class="fl">0.6</span>, + error_model <span class="op">=</span> <span class="va">object</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">err_mod</span>, + add_attributes <span class="op">=</span> <span class="cn">FALSE</span> +<span class="op">)</span> + +<span class="fu">nlmixr_data</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <a href="mmkin.html">mmkin</a> row object containing several fits of the same +<a href="mkinmod.html">mkinmod</a> model to different datasets</p></dd> +<dt>data</dt> +<dd><p>Not used, as the data are extracted from the mmkin row object</p></dd> +<dt>est</dt> +<dd><p>Estimation method passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> +<dt>control</dt> +<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> +<dt>table</dt> +<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> +<dt>error_model</dt> +<dd><p>Optional argument to override the error model which is +being set based on the error model used in the mmkin row object.</p></dd> +<dt>test_log_parms</dt> +<dd><p>If TRUE, an attempt is made to use more robust starting +values for population parameters fitted as log parameters in mkin (like +rate constants) by only considering rate constants that pass the t-test +when calculating mean degradation parameters using <a href="mean_degparms.html">mean_degparms</a>.</p></dd> +<dt>conf.level</dt> +<dd><p>Possibility to adjust the required confidence level +for parameter that are tested if requested by 'test_log_parms'.</p></dd> +<dt>degparms_start</dt> +<dd><p>Parameter values given as a named numeric vector will +be used to override the starting values obtained from the 'mmkin' object.</p></dd> +<dt>eta_start</dt> +<dd><p>Standard deviations on the transformed scale given as a +named numeric vector will be used to override the starting values obtained +from the 'mmkin' object.</p></dd> +<dt>...</dt> +<dd><p>Passed to nlmixr_model</p></dd> +<dt>save</dt> +<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> +<dt>envir</dt> +<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> +<dt>x</dt> +<dd><p>An nlmixr.mmkin object to print</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +<dt>add_attributes</dt> +<dd><p>Should the starting values used for degradation model +parameters and their distribution and for the error model parameters +be returned as attributes?</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An S3 object of class 'nlmixr.mmkin', containing the fitted +<a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a> object as a list component named 'nm'. The +object also inherits from 'mixed.mmkin'. +An function defining a model suitable for fitting with <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a>. +An dataframe suitable for use with <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p> + </div> + <div id="details"> + <h2>Details</h2> + <p>An mmkin row object is essentially a list of mkinfit objects that have been +obtained by fitting the same model to a list of datasets using <a href="mkinfit.html">mkinfit</a>.</p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><a href="summary.nlmixr.mmkin.html">summary.nlmixr.mmkin</a> <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_mmkin_parent</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mmkin_parent_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> +<span class="r-in"> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/nlmixrdevelopment/nlmixr" class="external-link">nlmixr</a></span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Attaching package: ‘nlmixr’</span> +<span class="r-msg co"><span class="r-pr">#></span> The following object is masked from ‘package:mkin’:</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> saem</span> +<span class="r-in"><span class="va">f_nlmixr_sfo_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> RxODE 1.1.4 using 8 threads (see ?getRxThreads)</span> +<span class="r-msg co"><span class="r-pr">#></span> no cache: create with `rxCreateCache()`</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_sfo_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_nlmixr_fomc_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_fomc_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_nlmixr_dfop_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_nlmixr_hs_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_hs_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using S matrix to calculate covariance, can check sandwich or R matrix with $covRS and $covR</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_nlmixr_fomc_saem_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_fomc_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>parameter estimate near boundary; covariance not calculated:</span> +<span class="r-wrn co"><span class="r-pr">#></span> "rsd_high" </span> +<span class="r-wrn co"><span class="r-pr">#></span> use 'getVarCov' to calculate anyway</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="va">f_nlmixr_sfo_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_sfo_focei</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_fomc_focei</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_dfop_focei</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_hs_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_hs_focei</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_saem_tc</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_fomc_focei_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_saem$nm 5 624.9492</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_focei$nm 5 625.0695</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_saem$nm 7 463.7577</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_focei$nm 7 468.0861</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_saem$nm 9 495.1980</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_focei$nm 9 495.1072</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_hs_saem$nm 9 531.0689</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_hs_focei$nm 9 545.6728</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_saem_tc$nm 8 462.1411</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_focei_tc$nm 8 470.0745</span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 468.0781</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 535.609</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The FOCEI fit of FOMC with constant variance or the tc error model is best</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_saem_tc</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlmixr.mmkin-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fomc_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_mmkin_const</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"const"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mmkin_obs</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mmkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu">nlmixr_model</span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Constant variance for more than one variable is not supported for est = 'saem'</span> +<span class="r-msg co"><span class="r-pr">#></span> Changing the error model to 'obs' (variance by observed variable)</span> +<span class="r-out co"><span class="r-pr">#></span> function () </span> +<span class="r-out co"><span class="r-pr">#></span> {</span> +<span class="r-out co"><span class="r-pr">#></span> ini({</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 = 87</span> +<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 ~ 4.2</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent = -3.2</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_parent ~ 1.5</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_A1 = -4.6</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 ~ 0.56</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis = -0.33</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis ~ 1.1</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_parent = 4.3</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_A1 = 4.3</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> model({</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0_model = parent_0 + eta.parent_0</span> +<span class="r-out co"><span class="r-pr">#></span> parent(0) = parent_0_model</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent = exp(log_k_parent + eta.log_k_parent)</span> +<span class="r-out co"><span class="r-pr">#></span> k_A1 = exp(log_k_A1 + eta.log_k_A1)</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_A1 = expit(f_parent_qlogis + eta.f_parent_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(parent) = -k_parent * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(A1) = +f_parent_to_A1 * k_parent * parent - k_A1 * </span> +<span class="r-out co"><span class="r-pr">#></span> A1</span> +<span class="r-out co"><span class="r-pr">#></span> parent ~ add(sigma_parent)</span> +<span class="r-out co"><span class="r-pr">#></span> A1 ~ add(sigma_A1)</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> }</span> +<span class="r-out co"><span class="r-pr">#></span> <environment: 0x555564a5b090></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># A single constant variance is currently only possible with est = 'focei' in nlmixr</span></span> +<span class="r-in"><span class="va">f_nlmixr_sfo_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 |log_k_parent | log_k_A1 |f_parent_qlogis |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| sigma | o1 | o2 | o3 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o4 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 756.61847 | 1.000 | -0.9694 | -1.000 | -0.9068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8057 | -0.8843 | -0.8798 | -0.8743 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8782 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 756.61847 | 87.00 | -3.200 | -4.600 | -0.3300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.300 | 0.6985 | 0.9036 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9765 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 756.61847</span> | 87.00 | 0.04076 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.300 | 0.6985 | 0.9036 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9765 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 104.1 | 0.02915 | 0.3320 | 0.4427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -29.46 | 6.499 | 3.260 | -8.158 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.501 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 4014.8405 | 0.04387 | -0.9697 | -1.003 | -0.9108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5352 | -0.9440 | -0.9098 | -0.7994 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8277 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 4014.8405 | 3.817 | -3.200 | -4.603 | -0.3313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.882 | 0.6569 | 0.8766 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.026 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 4014.8405</span> | 3.817 | 0.04075 | 0.01002 | 0.4179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.882 | 0.6569 | 0.8766 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.026 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 784.09766 | 0.9044 | -0.9695 | -1.000 | -0.9072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.8903 | -0.8828 | -0.8668 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8732 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 784.09766 | 78.68 | -3.200 | -4.600 | -0.3301 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.358 | 0.6944 | 0.9009 | 1.165 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9814 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 784.09766</span> | 78.68 | 0.04076 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.358 | 0.6944 | 0.9009 | 1.165 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9814 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 755.85897 | 0.9864 | -0.9694 | -1.000 | -0.9068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8018 | -0.8852 | -0.8803 | -0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8775 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 755.85897 | 85.82 | -3.200 | -4.600 | -0.3300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.308 | 0.6979 | 0.9032 | 1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9772 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.85897</span> | 85.82 | 0.04076 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.308 | 0.6979 | 0.9032 | 1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9772 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.67 | 0.1182 | 0.2197 | 0.3686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -28.82 | 3.860 | 3.200 | -8.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.254 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 755.50135 | 0.9911 | -0.9695 | -1.000 | -0.9070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7893 | -0.8868 | -0.8816 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8752 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 755.50135 | 86.22 | -3.200 | -4.600 | -0.3301 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.335 | 0.6968 | 0.9020 | 1.161 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9794 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.50135</span> | 86.22 | 0.04076 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.335 | 0.6968 | 0.9020 | 1.161 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9794 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 755.34910 | 0.9966 | -0.9695 | -1.000 | -0.9072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7744 | -0.8888 | -0.8833 | -0.8654 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8725 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 755.3491 | 86.70 | -3.200 | -4.600 | -0.3301 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.367 | 0.6954 | 0.9005 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9820 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.3491</span> | 86.70 | 0.04076 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.367 | 0.6954 | 0.9005 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9820 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 73.92 | 0.04965 | 0.3063 | 0.4373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -23.46 | 5.143 | 2.934 | -7.746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.165 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 754.44379 | 0.9831 | -0.9697 | -1.001 | -0.9076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7489 | -0.8930 | -0.8865 | -0.8566 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8669 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 754.44379 | 85.53 | -3.200 | -4.601 | -0.3303 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.422 | 0.6925 | 0.8975 | 1.176 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9875 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 754.44379</span> | 85.53 | 0.04075 | 0.01005 | 0.4182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.422 | 0.6925 | 0.8975 | 1.176 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9875 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.39 | 0.1354 | 0.1953 | 0.3724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -19.20 | 3.020 | 2.621 | -7.506 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.671 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 753.82350 | 0.9908 | -0.9699 | -1.001 | -0.9085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7249 | -0.8992 | -0.8910 | -0.8427 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8580 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 753.8235 | 86.20 | -3.200 | -4.601 | -0.3306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.474 | 0.6881 | 0.8935 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9962 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.8235</span> | 86.20 | 0.04074 | 0.01004 | 0.4181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.474 | 0.6881 | 0.8935 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9962 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 25.33 | 0.08213 | 0.2542 | 0.4339 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -14.89 | 3.322 | 2.230 | -6.934 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.324 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 753.42397 | 0.9836 | -0.9702 | -1.002 | -0.9101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7094 | -0.9058 | -0.8962 | -0.8215 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8457 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 753.42397 | 85.57 | -3.201 | -4.602 | -0.3311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.507 | 0.6835 | 0.8888 | 1.217 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.008 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.42397</span> | 85.57 | 0.04073 | 0.01003 | 0.4180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.507 | 0.6835 | 0.8888 | 1.217 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.008 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.38 | 0.1220 | 0.1752 | 0.4111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -12.58 | 2.402 | 1.769 | -6.044 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.541 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 753.10125 | 0.9902 | -0.9707 | -1.003 | -0.9128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7033 | -0.9147 | -0.8999 | -0.7966 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8328 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 753.10125 | 86.15 | -3.201 | -4.603 | -0.3320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.520 | 0.6773 | 0.8855 | 1.246 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.021 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.10125</span> | 86.15 | 0.04071 | 0.01002 | 0.4178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.520 | 0.6773 | 0.8855 | 1.246 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.021 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.19 | 0.07644 | 0.2005 | 0.4693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -11.34 | 2.660 | 1.470 | -4.866 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.908 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 752.83558 | 0.9856 | -0.9716 | -1.004 | -0.9194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6931 | -0.9294 | -0.8999 | -0.7740 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8246 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.83558 | 85.75 | -3.202 | -4.604 | -0.3342 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.542 | 0.6671 | 0.8855 | 1.272 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.029 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.83558</span> | 85.75 | 0.04067 | 0.01001 | 0.4172 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.542 | 0.6671 | 0.8855 | 1.272 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.029 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.42 | 0.09700 | 0.1175 | 0.4453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -9.793 | 1.829 | 1.489 | -3.997 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.337 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 752.64046 | 0.9898 | -0.9731 | -1.005 | -0.9331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6718 | -0.9413 | -0.9101 | -0.7759 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8318 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.64046 | 86.12 | -3.204 | -4.605 | -0.3387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.588 | 0.6587 | 0.8763 | 1.270 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.022 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.64046</span> | 86.12 | 0.04061 | 0.01000 | 0.4161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.588 | 0.6587 | 0.8763 | 1.270 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.022 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.96 | 0.06018 | 0.1556 | 0.4415 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -6.445 | 1.822 | 0.6282 | -4.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.761 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 752.52461 | 0.9874 | -0.9741 | -1.006 | -0.9430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6755 | -0.9483 | -0.9069 | -0.7553 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8127 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.52461 | 85.90 | -3.205 | -4.606 | -0.3420 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.580 | 0.6538 | 0.8792 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.52461</span> | 85.90 | 0.04057 | 0.009996 | 0.4153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.580 | 0.6538 | 0.8792 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.319 | 0.06758 | 0.1323 | 0.4528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -7.018 | 1.348 | 0.9128 | -3.312 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.706 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 752.47650 | 0.9920 | -0.9750 | -1.008 | -0.9578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6735 | -0.9481 | -0.9014 | -0.7293 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8100 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.4765 | 86.30 | -3.206 | -4.608 | -0.3468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.584 | 0.6539 | 0.8841 | 1.324 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.043 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.4765</span> | 86.30 | 0.04054 | 0.009974 | 0.4142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.584 | 0.6539 | 0.8841 | 1.324 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.043 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.38 | 0.03719 | 0.08701 | 0.4621 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -6.642 | 1.808 | 1.401 | -2.463 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.595 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 752.37074 | 0.9880 | -0.9759 | -1.009 | -0.9778 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6665 | -0.9465 | -0.9156 | -0.7192 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8239 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.37074 | 85.96 | -3.206 | -4.609 | -0.3534 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.599 | 0.6551 | 0.8713 | 1.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.030 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.37074</span> | 85.96 | 0.04050 | 0.009963 | 0.4125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.599 | 0.6551 | 0.8713 | 1.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.030 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8866 | 0.05090 | -0.01541 | 0.3812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.712 | 1.436 | 0.1646 | -2.191 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.247 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 752.26949 | 0.9921 | -0.9761 | -1.009 | -0.9796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6402 | -0.9531 | -0.9164 | -0.7091 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8135 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.26949 | 86.31 | -3.207 | -4.609 | -0.3540 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6505 | 0.8706 | 1.347 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.26949</span> | 86.31 | 0.04049 | 0.009963 | 0.4124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6505 | 0.8706 | 1.347 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.82 | 0.02710 | 0.03892 | 0.4267 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.005 | 1.500 | 0.1022 | -1.862 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.773 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 752.20271 | 0.9873 | -0.9768 | -1.006 | -0.9927 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6361 | -0.9677 | -0.9007 | -0.7162 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7982 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.20271 | 85.89 | -3.207 | -4.606 | -0.3584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.664 | 0.6403 | 0.8848 | 1.339 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.055 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.20271</span> | 85.89 | 0.04046 | 0.009992 | 0.4114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.664 | 0.6403 | 0.8848 | 1.339 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.055 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.259 | 0.05081 | 0.1320 | 0.4166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.497 | 0.4663 | 1.471 | -1.984 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9590 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 752.16826 | 0.9883 | -0.9778 | -1.006 | -1.005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6437 | -0.9795 | -0.9210 | -0.7076 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.16826 | 85.98 | -3.208 | -4.606 | -0.3626 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.648 | 0.6320 | 0.8664 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.16826</span> | 85.98 | 0.04042 | 0.009989 | 0.4103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.648 | 0.6320 | 0.8664 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.732 | 0.03428 | 0.1666 | 0.4265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.413 | 0.2526 | -0.2557 | -1.689 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3553 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 752.25223 | 0.9952 | -0.9788 | -1.010 | -1.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6370 | -0.9826 | -0.9156 | -0.6853 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7912 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.25223 | 86.58 | -3.209 | -4.610 | -0.3684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.663 | 0.6299 | 0.8713 | 1.374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.25223</span> | 86.58 | 0.04038 | 0.009949 | 0.4089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.663 | 0.6299 | 0.8713 | 1.374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 752.18605 | 0.9920 | -0.9778 | -1.007 | -1.006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6387 | -0.9801 | -0.9204 | -0.7040 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7866 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.18605 | 86.30 | -3.208 | -4.607 | -0.3629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8669 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.18605</span> | 86.30 | 0.04042 | 0.009985 | 0.4103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8669 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 752.16428 | 0.9894 | -0.9778 | -1.006 | -1.006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6422 | -0.9797 | -0.9208 | -0.7065 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7871 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.16428 | 86.08 | -3.208 | -4.606 | -0.3627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.651 | 0.6319 | 0.8666 | 1.350 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.16428</span> | 86.08 | 0.04042 | 0.009988 | 0.4103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.651 | 0.6319 | 0.8666 | 1.350 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.144 | 0.02886 | 0.1726 | 0.4333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.192 | 0.3285 | -0.2407 | -1.661 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3568 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 752.15919 | 0.9884 | -0.9779 | -1.007 | -1.007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6420 | -0.9798 | -0.9206 | -0.7051 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7874 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.15919 | 85.99 | -3.208 | -4.607 | -0.3630 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.652 | 0.6319 | 0.8668 | 1.352 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15919</span> | 85.99 | 0.04042 | 0.009985 | 0.4102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.652 | 0.6319 | 0.8668 | 1.352 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.486 | 0.03361 | 0.1549 | 0.4244 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.177 | 0.2364 | -0.2213 | -1.616 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3570 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 752.15545 | 0.9894 | -0.9779 | -1.007 | -1.007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6405 | -0.9799 | -0.9204 | -0.7040 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.15545 | 86.07 | -3.208 | -4.607 | -0.3631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.655 | 0.6318 | 0.8669 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15545</span> | 86.07 | 0.04042 | 0.009984 | 0.4102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.655 | 0.6318 | 0.8669 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.936 | 0.02854 | 0.1600 | 0.4306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.962 | 0.3065 | -0.2063 | -1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3570 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 752.15077 | 0.9884 | -0.9779 | -1.007 | -1.008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6403 | -0.9800 | -0.9202 | -0.7026 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7875 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.15077 | 85.99 | -3.209 | -4.607 | -0.3635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6317 | 0.8672 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15077</span> | 85.99 | 0.04042 | 0.009981 | 0.4101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6317 | 0.8672 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.303 | 0.03292 | 0.1430 | 0.4220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.955 | 0.2207 | -0.1874 | -1.542 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3581 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 752.14731 | 0.9893 | -0.9780 | -1.007 | -1.009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6389 | -0.9801 | -0.9200 | -0.7014 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.14731 | 86.07 | -3.209 | -4.607 | -0.3637 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8673 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.14731</span> | 86.07 | 0.04042 | 0.009980 | 0.4101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8673 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.764 | 0.02806 | 0.1473 | 0.4277 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.749 | 0.2865 | -0.1727 | -1.510 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3572 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 752.14299 | 0.9884 | -0.9780 | -1.007 | -1.010 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6388 | -0.9801 | -0.9198 | -0.7000 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.14299 | 85.99 | -3.209 | -4.607 | -0.3641 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8675 | 1.358 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.14299</span> | 85.99 | 0.04041 | 0.009978 | 0.4100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8675 | 1.358 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.130 | 0.03192 | 0.1311 | 0.4194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.750 | 0.2064 | -0.1542 | -1.466 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3587 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 752.13982 | 0.9893 | -0.9781 | -1.008 | -1.010 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6374 | -0.9803 | -0.9196 | -0.6987 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.13982 | 86.07 | -3.209 | -4.608 | -0.3642 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8676 | 1.359 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.13982</span> | 86.07 | 0.04041 | 0.009977 | 0.4099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8676 | 1.359 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.635 | 0.02760 | 0.1350 | 0.4248 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.550 | 0.2683 | -0.1407 | -1.433 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3557 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 752.13580 | 0.9884 | -0.9782 | -1.008 | -1.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6373 | -0.9803 | -0.9194 | -0.6973 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.1358 | 85.99 | -3.209 | -4.608 | -0.3647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8678 | 1.361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.1358</span> | 85.99 | 0.04041 | 0.009975 | 0.4098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8678 | 1.361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.9657 | 0.03147 | 0.1207 | 0.4166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.557 | 0.1931 | -0.1227 | -1.391 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3574 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 752.13295 | 0.9893 | -0.9782 | -1.008 | -1.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6359 | -0.9805 | -0.9193 | -0.6961 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.13295 | 86.07 | -3.209 | -4.608 | -0.3648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8679 | 1.362 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.13295</span> | 86.07 | 0.04041 | 0.009973 | 0.4098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8679 | 1.362 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.554 | 0.02702 | 0.1245 | 0.4220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.357 | 0.2511 | -0.1114 | -1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3512 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 752.12919 | 0.9885 | -0.9783 | -1.008 | -1.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6359 | -0.9804 | -0.9191 | -0.6947 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.12919 | 86.00 | -3.209 | -4.608 | -0.3653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8681 | 1.364 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12919</span> | 86.00 | 0.04040 | 0.009972 | 0.4097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8681 | 1.364 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8077 | 0.03076 | 0.1104 | 0.4140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.370 | 0.1799 | -0.09417 | -1.307 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3529 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 752.12656 | 0.9893 | -0.9783 | -1.008 | -1.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6345 | -0.9806 | -0.9190 | -0.6934 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.12656 | 86.07 | -3.209 | -4.608 | -0.3654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8682 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12656</span> | 86.07 | 0.04040 | 0.009970 | 0.4096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8682 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.375 | 0.02651 | 0.1140 | 0.4191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.173 | 0.2330 | -0.08481 | -1.281 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3435 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 752.12310 | 0.9885 | -0.9784 | -1.008 | -1.016 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6345 | -0.9806 | -0.9188 | -0.6922 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7875 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.1231 | 86.00 | -3.209 | -4.608 | -0.3659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8684 | 1.367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.1231</span> | 86.00 | 0.04040 | 0.009969 | 0.4095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8684 | 1.367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.6515 | 0.02994 | 0.1012 | 0.4113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.192 | 0.1669 | -0.06829 | -1.233 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3455 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 752.12055 | 0.9892 | -0.9784 | -1.008 | -1.016 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6332 | -0.9808 | -0.9187 | -0.6908 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7871 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.12055 | 86.06 | -3.209 | -4.608 | -0.3661 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8685 | 1.368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12055</span> | 86.06 | 0.04040 | 0.009968 | 0.4095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8685 | 1.368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.998 | 0.02610 | 0.1041 | 0.4159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | 0.2127 | -0.06061 | -1.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3333 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 752.11747 | 0.9885 | -0.9785 | -1.009 | -1.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6332 | -0.9807 | -0.9185 | -0.6896 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7874 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.11747 | 86.00 | -3.209 | -4.609 | -0.3666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8687 | 1.370 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11747</span> | 86.00 | 0.04039 | 0.009966 | 0.4094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8687 | 1.370 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5772 | 0.02918 | 0.09258 | 0.4085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | 0.1535 | -0.04467 | -1.159 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3360 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 752.11522 | 0.9892 | -0.9785 | -1.009 | -1.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6319 | -0.9809 | -0.9185 | -0.6881 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7870 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.11522 | 86.06 | -3.209 | -4.609 | -0.3668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.674 | 0.6311 | 0.8687 | 1.371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11522</span> | 86.06 | 0.04039 | 0.009965 | 0.4093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.674 | 0.6311 | 0.8687 | 1.371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.959 | 0.02535 | 0.09612 | 0.4130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8451 | 0.1980 | -0.03883 | -1.121 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3219 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 752.11234 | 0.9885 | -0.9786 | -1.009 | -1.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6320 | -0.9808 | -0.9183 | -0.6870 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.11234 | 86.00 | -3.209 | -4.609 | -0.3673 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | 0.6311 | 0.8689 | 1.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11234</span> | 86.00 | 0.04039 | 0.009964 | 0.4092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | 0.6311 | 0.8689 | 1.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5042 | 0.02791 | 0.08363 | 0.4056 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8741 | 0.1402 | -0.02542 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3257 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 752.11033 | 0.9892 | -0.9787 | -1.009 | -1.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6308 | -0.9810 | -0.9182 | -0.6855 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7868 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.11033 | 86.06 | -3.209 | -4.609 | -0.3675 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8689 | 1.374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11033</span> | 86.06 | 0.04039 | 0.009963 | 0.4091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8689 | 1.374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.874 | 0.02465 | 0.08719 | 0.4100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7032 | 0.1835 | -0.01978 | -1.047 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3084 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 752.10764 | 0.9885 | -0.9787 | -1.009 | -1.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6309 | -0.9810 | -0.9181 | -0.6844 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7870 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.10764 | 86.00 | -3.209 | -4.609 | -0.3681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8691 | 1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10764</span> | 86.00 | 0.04038 | 0.009962 | 0.4090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8691 | 1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4131 | 0.02699 | 0.07721 | 0.4026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7354 | 0.1282 | -0.007503 | -1.011 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3125 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 752.10572 | 0.9892 | -0.9788 | -1.009 | -1.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6298 | -0.9812 | -0.9181 | -0.6829 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7865 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.10572 | 86.06 | -3.209 | -4.609 | -0.3683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8691 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10572</span> | 86.06 | 0.04038 | 0.009960 | 0.4090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8691 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.580 | 0.02411 | 0.07834 | 0.4067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5755 | 0.1666 | -0.003596 | -0.9604 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2924 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 752.10333 | 0.9885 | -0.9789 | -1.009 | -1.024 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6300 | -0.9811 | -0.9179 | -0.6819 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7867 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.10333 | 86.00 | -3.209 | -4.609 | -0.3688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8692 | 1.378 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10333</span> | 86.00 | 0.04038 | 0.009959 | 0.4088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8692 | 1.378 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3772 | 0.02648 | 0.06875 | 0.3997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6082 | 0.1162 | 0.008208 | -0.9328 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2962 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 752.10169 | 0.9892 | -0.9789 | -1.009 | -1.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6289 | -0.9813 | -0.9179 | -0.6803 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7862 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.10169 | 86.06 | -3.209 | -4.609 | -0.3691 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8692 | 1.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10169</span> | 86.06 | 0.04038 | 0.009958 | 0.4088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8692 | 1.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.644 | 0.02338 | 0.07127 | 0.4037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4618 | 0.1554 | 0.009391 | -0.8908 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2755 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 752.09938 | 0.9886 | -0.9790 | -1.009 | -1.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6291 | -0.9812 | -0.9178 | -0.6794 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7864 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.09938 | 86.00 | -3.210 | -4.609 | -0.3697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8693 | 1.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09938</span> | 86.00 | 0.04037 | 0.009958 | 0.4086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8693 | 1.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2627 | 0.02548 | 0.06256 | 0.3967 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4955 | 0.1055 | 0.02027 | -0.8653 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2789 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 752.09757 | 0.9890 | -0.9791 | -1.010 | -1.028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6281 | -0.9814 | -0.9178 | -0.6778 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7859 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.09757 | 86.05 | -3.210 | -4.610 | -0.3699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.682 | 0.6307 | 0.8693 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09757</span> | 86.05 | 0.04037 | 0.009956 | 0.4086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.682 | 0.6307 | 0.8693 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.867 | 0.02296 | 0.06369 | 0.3997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3645 | 0.1327 | 0.01894 | -0.8216 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2549 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 752.09570 | 0.9886 | -0.9791 | -1.010 | -1.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6283 | -0.9814 | -0.9177 | -0.6770 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7861 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.0957 | 86.00 | -3.210 | -4.610 | -0.3705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.681 | 0.6307 | 0.8694 | 1.384 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.0957</span> | 86.00 | 0.04037 | 0.009956 | 0.4084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.681 | 0.6307 | 0.8694 | 1.384 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2846 | 0.02474 | 0.05675 | 0.3935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3960 | 0.09353 | 0.02976 | -0.7961 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2595 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 752.09434 | 0.9891 | -0.9792 | -1.010 | -1.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6275 | -0.9816 | -0.9177 | -0.6754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7856 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.09434 | 86.05 | -3.210 | -4.610 | -0.3708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8694 | 1.386 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09434</span> | 86.05 | 0.04037 | 0.009955 | 0.4083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8694 | 1.386 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.348 | 0.02147 | 0.05816 | 0.3967 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2833 | 0.1286 | 0.02562 | -0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2380 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 752.09236 | 0.9886 | -0.9793 | -1.010 | -1.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6277 | -0.9815 | -0.9176 | -0.6746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7858 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.09236 | 86.01 | -3.210 | -4.610 | -0.3715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8695 | 1.387 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09236</span> | 86.01 | 0.04036 | 0.009954 | 0.4082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8695 | 1.387 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1856 | 0.02378 | 0.05144 | 0.3902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3147 | 0.08386 | 0.03545 | -0.7433 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2408 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 752.09077 | 0.9890 | -0.9793 | -1.010 | -1.033 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6269 | -0.9817 | -0.9177 | -0.6729 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.09077 | 86.04 | -3.210 | -4.610 | -0.3717 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8694 | 1.389 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09077</span> | 86.04 | 0.04036 | 0.009953 | 0.4081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8694 | 1.389 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 752.08937 | 0.9892 | -0.9795 | -1.010 | -1.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6267 | -0.9818 | -0.9176 | -0.6714 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.08937 | 86.06 | -3.210 | -4.610 | -0.3725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.685 | 0.6304 | 0.8695 | 1.391 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08937</span> | 86.06 | 0.04036 | 0.009952 | 0.4079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.685 | 0.6304 | 0.8695 | 1.391 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.945 | 0.01952 | 0.05064 | 0.3906 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1866 | 0.1233 | 0.03740 | -0.6554 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2138 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 752.08593 | 0.9886 | -0.9796 | -1.010 | -1.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6271 | -0.9817 | -0.9174 | -0.6701 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7856 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.08593 | 86.01 | -3.210 | -4.610 | -0.3740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8697 | 1.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08593</span> | 86.01 | 0.04035 | 0.009951 | 0.4076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8697 | 1.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.04707 | 0.02143 | 0.04311 | 0.3795 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2514 | 0.07631 | 0.05739 | -0.6184 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2313 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 752.08243 | 0.9889 | -0.9798 | -1.010 | -1.042 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6256 | -0.9821 | -0.9177 | -0.6665 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7842 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.08243 | 86.03 | -3.210 | -4.610 | -0.3748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6302 | 0.8694 | 1.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08243</span> | 86.03 | 0.04034 | 0.009949 | 0.4074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6302 | 0.8694 | 1.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 752.07616 | 0.9895 | -0.9803 | -1.011 | -1.054 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6231 | -0.9827 | -0.9181 | -0.6582 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7817 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.07616 | 86.08 | -3.211 | -4.611 | -0.3786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.693 | 0.6298 | 0.8690 | 1.406 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.071 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.07616</span> | 86.08 | 0.04032 | 0.009942 | 0.4065 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.693 | 0.6298 | 0.8690 | 1.406 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.071 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.128 | 0.01286 | 0.03023 | 0.3726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2708 | 0.07184 | -0.02487 | -0.2959 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03882 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 752.06706 | 0.9888 | -0.9810 | -1.011 | -1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6241 | -0.9834 | -0.9174 | -0.6562 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7830 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.06706 | 86.03 | -3.212 | -4.611 | -0.3848 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.690 | 0.6293 | 0.8696 | 1.408 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.069 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.06706</span> | 86.03 | 0.04030 | 0.009938 | 0.4050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.690 | 0.6293 | 0.8696 | 1.408 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.069 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 752.05726 | 0.9892 | -0.9821 | -1.012 | -1.106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6257 | -0.9847 | -0.9162 | -0.6528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7853 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.05726 | 86.06 | -3.213 | -4.612 | -0.3958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6284 | 0.8707 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.05726</span> | 86.06 | 0.04025 | 0.009929 | 0.4023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6284 | 0.8707 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 752.04392 | 0.9898 | -0.9854 | -1.015 | -1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6305 | -0.9883 | -0.9128 | -0.6430 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7918 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.04392 | 86.11 | -3.216 | -4.615 | -0.4269 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.677 | 0.6259 | 0.8738 | 1.423 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.04392</span> | 86.11 | 0.04012 | 0.009906 | 0.3949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.677 | 0.6259 | 0.8738 | 1.423 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.566 | -0.02004 | 0.02472 | 0.1678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6767 | -0.003606 | 0.4773 | 0.08205 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6933 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 752.05860 | 0.9880 | -0.9900 | -1.027 | -1.486 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6186 | -0.9338 | -0.9168 | -0.6653 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7443 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.0586 | 85.96 | -3.221 | -4.627 | -0.5212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.702 | 0.6640 | 0.8702 | 1.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.0586</span> | 85.96 | 0.03993 | 0.009780 | 0.3726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.702 | 0.6640 | 0.8702 | 1.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 752.02137 | 0.9885 | -0.9874 | -1.020 | -1.325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6252 | -0.9645 | -0.9146 | -0.6528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7710 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.02137 | 86.00 | -3.218 | -4.620 | -0.4681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.02137</span> | 86.00 | 0.04004 | 0.009850 | 0.3851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.728 | -0.02729 | 0.08518 | 0.04185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2367 | 0.4063 | 0.2432 | 0.01436 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.07563 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 752.06656 | 0.9886 | -0.9792 | -1.053 | -1.433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6165 | -1.020 | -0.9133 | -0.6801 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7607 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.06656 | 86.01 | -3.210 | -4.653 | -0.5037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.707 | 0.6037 | 0.8734 | 1.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.06656</span> | 86.01 | 0.04036 | 0.009533 | 0.3767 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.707 | 0.6037 | 0.8734 | 1.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 752.02137 | 0.9885 | -0.9874 | -1.020 | -1.325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6252 | -0.9645 | -0.9146 | -0.6528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7710 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 752.02137 | 86.00 | -3.218 | -4.620 | -0.4681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.02137</span> | 86.00 | 0.04004 | 0.009850 | 0.3851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta | sigma | o1 | o2 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o3 | o4 | o5 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 494.78160 | 1.000 | -1.000 | -0.9115 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.8592 | -0.8761 | -0.8740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8674 | -0.8694 | -0.8683 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.7816 | 94.00 | -5.400 | -1.000 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.600 | 0.7598 | 0.8633 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.189 | 1.089 | 1.146 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.7816</span> | 94.00 | 0.004517 | 0.2689 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.600 | 0.7598 | 0.8633 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.189 | 1.089 | 1.146 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -28.01 | 1.933 | -0.2086 | 0.01492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1687 | -59.79 | 10.74 | 9.966 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.82 | -8.862 | -10.52 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1353.4477 | 1.400 | -1.028 | -0.9085 | -0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.005584 | -1.029 | -1.016 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6987 | -0.7429 | -0.7181 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 1353.4477 | 131.6 | -5.428 | -0.9970 | -0.2002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.283 | 0.6433 | 0.7405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.390 | 1.227 | 1.318 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1353.4477</span> | 131.6 | 0.004394 | 0.2695 | 0.8186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 2.283 | 0.6433 | 0.7405 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.390 | 1.227 | 1.318 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 504.82409 | 1.040 | -1.003 | -0.9112 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7738 | -0.8914 | -0.8882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8506 | -0.8568 | -0.8533 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 504.82409 | 97.76 | -5.403 | -0.9997 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.668 | 0.7482 | 0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.209 | 1.103 | 1.163 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 504.82409</span> | 97.76 | 0.004504 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.668 | 0.7482 | 0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.209 | 1.103 | 1.163 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 494.10898 | 1.008 | -1.001 | -0.9114 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8416 | -0.8792 | -0.8769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8640 | -0.8668 | -0.8652 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.10898 | 94.77 | -5.401 | -0.9999 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.614 | 0.7574 | 0.8608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.193 | 1.092 | 1.149 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.10898</span> | 94.77 | 0.004514 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.614 | 0.7574 | 0.8608 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.193 | 1.092 | 1.149 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 147.0 | 1.955 | -0.08761 | 0.06834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05948 | -55.61 | 11.89 | 8.304 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.01 | -8.510 | -10.24 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 492.58255 | 0.9992 | -1.001 | -0.9114 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8245 | -0.8825 | -0.8797 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8605 | -0.8643 | -0.8621 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 492.58255 | 93.93 | -5.401 | -0.9999 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.628 | 0.7550 | 0.8584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.197 | 1.095 | 1.153 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.58255</span> | 93.93 | 0.004511 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.628 | 0.7550 | 0.8584 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.197 | 1.095 | 1.153 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -43.22 | 1.882 | -0.2206 | -0.004719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1970 | -51.78 | 10.22 | 6.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.81 | -8.346 | -10.04 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 491.66702 | 1.006 | -1.002 | -0.9113 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8063 | -0.8860 | -0.8822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8565 | -0.8614 | -0.8588 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.66702 | 94.52 | -5.402 | -0.9998 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.642 | 0.7523 | 0.8562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.202 | 1.098 | 1.157 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.66702</span> | 94.52 | 0.004509 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.642 | 0.7523 | 0.8562 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.202 | 1.098 | 1.157 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 87.79 | 1.893 | -0.1269 | 0.04418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01699 | -47.85 | 10.34 | 7.758 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.67 | -8.213 | -9.916 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 490.57489 | 0.9987 | -1.002 | -0.9112 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7885 | -0.8895 | -0.8851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8525 | -0.8586 | -0.8553 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.57489 | 93.88 | -5.402 | -0.9998 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.657 | 0.7496 | 0.8537 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.207 | 1.101 | 1.161 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.57489</span> | 93.88 | 0.004506 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.657 | 0.7496 | 0.8537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.207 | 1.101 | 1.161 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -52.56 | 1.834 | -0.2285 | -0.01046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2159 | -44.44 | 9.379 | 7.248 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.47 | -8.044 | -9.710 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 489.67804 | 1.004 | -1.003 | -0.9112 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7706 | -0.8932 | -0.8884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8482 | -0.8554 | -0.8516 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 489.67804 | 94.42 | -5.403 | -0.9997 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.671 | 0.7468 | 0.8509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.212 | 1.105 | 1.165 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.67804</span> | 94.42 | 0.004503 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.671 | 0.7468 | 0.8509 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.212 | 1.105 | 1.165 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 63.10 | 1.841 | -0.1396 | 0.03713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05177 | -40.65 | 9.345 | 6.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.29 | -7.879 | -9.567 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 488.80457 | 0.9984 | -1.004 | -0.9111 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.7529 | -0.8970 | -0.8913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8435 | -0.8521 | -0.8475 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.80457 | 93.85 | -5.404 | -0.9996 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.685 | 0.7439 | 0.8484 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.218 | 1.108 | 1.170 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.80457</span> | 93.85 | 0.004499 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.685 | 0.7439 | 0.8484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.218 | 1.108 | 1.170 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -56.52 | 1.788 | -0.2313 | -0.01570 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2287 | -37.43 | 8.740 | 5.512 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.08 | -7.680 | -9.353 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 487.98244 | 1.004 | -1.005 | -0.9110 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.7356 | -0.9012 | -0.8939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8380 | -0.8482 | -0.8428 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.98244 | 94.36 | -5.405 | -0.9995 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.699 | 0.7407 | 0.8461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.224 | 1.112 | 1.175 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.98244</span> | 94.36 | 0.004495 | 0.2690 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.169 | 1.699 | 0.7407 | 0.8461 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.224 | 1.112 | 1.175 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.57 | 1.794 | -0.1466 | 0.03517 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07178 | -34.12 | 8.494 | 6.684 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.82 | -7.482 | -9.140 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 487.23587 | 0.9987 | -1.006 | -0.9109 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.7192 | -0.9058 | -0.8980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8316 | -0.8438 | -0.8374 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.23587 | 93.88 | -5.406 | -0.9994 | -0.2001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.712 | 0.7372 | 0.8426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.232 | 1.117 | 1.181 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.23587</span> | 93.88 | 0.004490 | 0.2691 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.712 | 0.7372 | 0.8426 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.232 | 1.117 | 1.181 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.22 | 1.745 | -0.2274 | -0.009194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2301 | -31.48 | 7.992 | 6.132 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.64 | -7.269 | -8.903 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 486.53337 | 1.004 | -1.007 | -0.9107 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.7047 | -0.9109 | -0.9037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8240 | -0.8386 | -0.8310 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 486.53337 | 94.34 | -5.407 | -0.9993 | -0.2001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.724 | 0.7334 | 0.8376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.241 | 1.123 | 1.189 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.53337</span> | 94.34 | 0.004484 | 0.2691 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.724 | 0.7334 | 0.8376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.241 | 1.123 | 1.189 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 43.47 | 1.742 | -0.1424 | 0.02918 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07089 | -28.76 | 7.629 | 4.806 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.24 | -6.953 | -8.584 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 485.91669 | 0.9989 | -1.009 | -0.9105 | -0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8484 | -0.6920 | -0.9165 | -0.9072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8145 | -0.8325 | -0.8231 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.91669 | 93.90 | -5.409 | -0.9991 | -0.2001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.734 | 0.7291 | 0.8346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.252 | 1.130 | 1.198 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.91669</span> | 93.90 | 0.004476 | 0.2691 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.734 | 0.7291 | 0.8346 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.252 | 1.130 | 1.198 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -44.30 | 1.699 | -0.2182 | 0.001936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2284 | -26.86 | 7.286 | 5.487 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.898 | -6.659 | -8.234 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 485.33976 | 1.003 | -1.011 | -0.9103 | -0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.6819 | -0.9228 | -0.9110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8035 | -0.8257 | -0.8143 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.33976 | 94.29 | -5.411 | -0.9988 | -0.2001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.742 | 0.7243 | 0.8314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.265 | 1.137 | 1.208 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.33976</span> | 94.29 | 0.004467 | 0.2692 | 0.8186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 1.742 | 0.7243 | 0.8314 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.265 | 1.137 | 1.208 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 484.77317 | 1.003 | -1.014 | -0.9100 | -0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8479 | -0.6718 | -0.9302 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7902 | -0.8175 | -0.8035 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.77317 | 94.32 | -5.414 | -0.9986 | -0.2002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.750 | 0.7187 | 0.8276 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.281 | 1.146 | 1.220 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.77317</span> | 94.32 | 0.004455 | 0.2692 | 0.8186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.176 | 1.750 | 0.7187 | 0.8276 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.281 | 1.146 | 1.220 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 483.17588 | 1.004 | -1.023 | -0.9091 | -0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.6384 | -0.9549 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7463 | -0.7903 | -0.7681 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.17588 | 94.41 | -5.423 | -0.9976 | -0.2004 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.777 | 0.6999 | 0.8153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.333 | 1.176 | 1.261 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.17588</span> | 94.41 | 0.004415 | 0.2694 | 0.8184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.777 | 0.6999 | 0.8153 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.333 | 1.176 | 1.261 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 481.21481 | 1.006 | -1.040 | -0.9072 | -0.8961 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8451 | -0.5721 | -1.004 | -0.9579 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6592 | -0.7365 | -0.6977 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.21481 | 94.58 | -5.440 | -0.9958 | -0.2008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.104 | 1.830 | 0.6628 | 0.7909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.437 | 1.234 | 1.341 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.21481</span> | 94.58 | 0.004338 | 0.2698 | 0.8181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.199 | 1.830 | 0.6628 | 0.7909 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.437 | 1.234 | 1.341 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 62.86 | 1.476 | 0.06730 | 0.05792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1123 | -8.977 | 1.055 | 2.914 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.044 | -1.094 | -2.299 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 481.29476 | 1.000 | -1.145 | -0.9129 | -0.8997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5378 | -0.8985 | -1.168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6228 | -0.8149 | -0.6969 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.29476 | 94.03 | -5.545 | -1.001 | -0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.857 | 0.7428 | 0.6099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.149 | 1.342 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.29476</span> | 94.03 | 0.003907 | 0.2687 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.857 | 0.7428 | 0.6099 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.149 | 1.342 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 480.77138 | 1.000 | -1.090 | -0.9099 | -0.8978 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.5555 | -0.9542 | -1.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6419 | -0.7733 | -0.6972 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.77138 | 94.01 | -5.490 | -0.9984 | -0.2025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.843 | 0.7004 | 0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.457 | 1.194 | 1.342 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.77138</span> | 94.01 | 0.004129 | 0.2693 | 0.8167 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 1.843 | 0.7004 | 0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.457 | 1.194 | 1.342 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -25.72 | 1.151 | 0.08772 | -0.007897 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07232 | -6.930 | 3.330 | -2.491 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.626 | -3.111 | -2.500 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 480.61717 | 1.001 | -1.203 | -0.9227 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5418 | -0.9405 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6281 | -0.7705 | -0.6908 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.61717 | 94.09 | -5.603 | -1.011 | -0.2049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.854 | 0.7108 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.197 | 1.349 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.61717</span> | 94.09 | 0.003688 | 0.2667 | 0.8147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.156 | 1.854 | 0.7108 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.197 | 1.349 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.61 | 0.9224 | -0.5881 | -0.06621 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1838 | -5.929 | 3.775 | 2.798 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.936 | -2.993 | -2.208 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 480.72130 | 1.009 | -1.314 | -0.9169 | -0.9003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5516 | -0.9873 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6340 | -0.7292 | -0.6819 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.7213 | 94.81 | -5.714 | -1.005 | -0.2049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.846 | 0.6753 | 0.7523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.467 | 1.242 | 1.359 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.7213</span> | 94.81 | 0.003299 | 0.2679 | 0.8147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.846 | 0.6753 | 0.7523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.467 | 1.242 | 1.359 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 480.86254 | 1.009 | -1.247 | -0.9202 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5429 | -0.9605 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6295 | -0.7530 | -0.6863 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.86254 | 94.84 | -5.647 | -1.009 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.853 | 0.6957 | 0.7520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.472 | 1.216 | 1.354 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.86254</span> | 94.84 | 0.003530 | 0.2672 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.853 | 0.6957 | 0.7520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.472 | 1.216 | 1.354 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 480.98412 | 1.009 | -1.209 | -0.9220 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5381 | -0.9458 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6270 | -0.7661 | -0.6887 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.98412 | 94.85 | -5.609 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7069 | 0.7519 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.202 | 1.352 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.98412</span> | 94.85 | 0.003664 | 0.2669 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7069 | 0.7519 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.202 | 1.352 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 480.60990 | 1.003 | -1.203 | -0.9226 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5410 | -0.9411 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6278 | -0.7701 | -0.6905 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.6099 | 94.24 | -5.603 | -1.011 | -0.2049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.855 | 0.7104 | 0.7534 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.198 | 1.350 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.6099</span> | 94.24 | 0.003688 | 0.2668 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.156 | 1.855 | 0.7104 | 0.7534 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.198 | 1.350 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.29 | 0.9278 | -0.5289 | -0.04762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1043 | -5.468 | 3.876 | 0.6273 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.897 | -2.941 | -2.183 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 480.59557 | 1.001 | -1.204 | -0.9225 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5407 | -0.9419 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6277 | -0.7694 | -0.6902 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.59557 | 94.13 | -5.604 | -1.011 | -0.2049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.855 | 0.7098 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.198 | 1.350 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.59557</span> | 94.13 | 0.003683 | 0.2668 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.855 | 0.7098 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.198 | 1.350 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.733 | 0.9212 | -0.5619 | -0.05855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1664 | -5.388 | 3.833 | 0.5854 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.924 | -2.927 | -2.102 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 480.58581 | 1.002 | -1.204 | -0.9224 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5395 | -0.9428 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6273 | -0.7688 | -0.6897 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.58581 | 94.23 | -5.604 | -1.011 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.856 | 0.7092 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.199 | 1.351 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.58581</span> | 94.23 | 0.003683 | 0.2668 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.856 | 0.7092 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.199 | 1.351 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.31 | 0.9226 | -0.5246 | -0.05019 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1134 | -5.293 | 3.771 | 0.5822 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.938 | -2.904 | -2.175 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 480.57360 | 1.001 | -1.205 | -0.9222 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5392 | -0.9437 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6271 | -0.7681 | -0.6894 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.5736 | 94.13 | -5.605 | -1.011 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.856 | 0.7085 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.200 | 1.351 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.5736</span> | 94.13 | 0.003678 | 0.2668 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.856 | 0.7085 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.200 | 1.351 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.864 | 0.9151 | -0.5515 | -0.06112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1679 | -5.184 | 3.617 | 0.5746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.832 | -2.849 | -2.141 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 480.56429 | 1.002 | -1.206 | -0.9220 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5382 | -0.9446 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6268 | -0.7674 | -0.6889 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.56429 | 94.23 | -5.606 | -1.011 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7078 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.201 | 1.351 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.56429</span> | 94.23 | 0.003676 | 0.2669 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7078 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.201 | 1.351 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.18 | 0.9169 | -0.5105 | -0.05061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1125 | -5.131 | 3.532 | 0.5638 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.931 | -2.821 | -2.132 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 480.55246 | 1.001 | -1.207 | -0.9218 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5380 | -0.9454 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6266 | -0.7667 | -0.6886 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.55246 | 94.13 | -5.607 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7071 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.201 | 1.352 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.55246</span> | 94.13 | 0.003672 | 0.2669 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7071 | 0.7532 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.201 | 1.352 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.480 | 0.9098 | -0.5353 | -0.06055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1647 | -5.053 | 3.625 | 0.5654 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.860 | -2.782 | -2.112 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 480.54335 | 1.002 | -1.207 | -0.9217 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5368 | -0.9463 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6262 | -0.7660 | -0.6881 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.54335 | 94.23 | -5.607 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.858 | 0.7065 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.202 | 1.352 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.54335</span> | 94.23 | 0.003671 | 0.2669 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.858 | 0.7065 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.202 | 1.352 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.09 | 0.9120 | -0.4955 | -0.05014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1107 | -4.912 | 3.583 | 0.5835 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.814 | -2.702 | -2.057 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 480.53185 | 1.001 | -1.209 | -0.9215 | -0.9002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5366 | -0.9472 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6260 | -0.7654 | -0.6878 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.53185 | 94.13 | -5.609 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.858 | 0.7058 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.203 | 1.353 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.53185</span> | 94.13 | 0.003666 | 0.2670 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.858 | 0.7058 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.203 | 1.353 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.509 | 0.9048 | -0.5214 | -0.06027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1665 | -4.870 | 3.525 | 0.5641 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.813 | -2.699 | -2.069 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 480.52276 | 1.002 | -1.209 | -0.9214 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5356 | -0.9481 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6256 | -0.7647 | -0.6873 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.52276 | 94.22 | -5.609 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.859 | 0.7051 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.203 | 1.353 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.52276</span> | 94.22 | 0.003664 | 0.2670 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.859 | 0.7051 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.203 | 1.353 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.38 | 0.9060 | -0.4821 | -0.05014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1110 | -4.747 | 3.479 | 0.5798 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.777 | -2.636 | -2.020 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 480.51194 | 1.001 | -1.211 | -0.9212 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5355 | -0.9490 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6255 | -0.7641 | -0.6869 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.51194 | 94.13 | -5.611 | -1.010 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.859 | 0.7044 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.204 | 1.354 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.51194</span> | 94.13 | 0.003659 | 0.2670 | 0.8148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.859 | 0.7044 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.204 | 1.354 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.485 | 0.8991 | -0.5064 | -0.06148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1643 | -4.758 | 3.403 | 0.5432 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.772 | -2.633 | -2.022 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 480.50302 | 1.002 | -1.211 | -0.9210 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5345 | -0.9500 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6251 | -0.7633 | -0.6864 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.50302 | 94.22 | -5.611 | -1.010 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.860 | 0.7037 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.205 | 1.354 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.50302</span> | 94.22 | 0.003656 | 0.2671 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.860 | 0.7037 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.205 | 1.354 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.83 | 0.8997 | -0.4680 | -0.05021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1106 | -4.703 | 3.332 | 0.5674 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.765 | -2.559 | -1.986 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 480.49281 | 1.001 | -1.213 | -0.9209 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5344 | -0.9509 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6250 | -0.7627 | -0.6860 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.49281 | 94.13 | -5.613 | -1.009 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.860 | 0.7030 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.206 | 1.355 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.49281</span> | 94.13 | 0.003652 | 0.2671 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.860 | 0.7030 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.206 | 1.355 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.447 | 0.8934 | -0.4900 | -0.06030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1577 | -4.708 | 3.266 | 0.5080 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.782 | -2.544 | -1.983 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 480.48415 | 1.002 | -1.213 | -0.9207 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8498 | -0.5335 | -0.9518 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6246 | -0.7620 | -0.6855 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.48415 | 94.22 | -5.613 | -1.009 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7023 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.206 | 1.355 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.48415</span> | 94.22 | 0.003649 | 0.2671 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.861 | 0.7023 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.206 | 1.355 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.47 | 0.8932 | -0.4526 | -0.04997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1093 | -4.502 | 3.250 | 0.5653 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.769 | -2.486 | -1.944 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 480.47437 | 1.001 | -1.215 | -0.9205 | -0.9001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8498 | -0.5334 | -0.9527 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6244 | -0.7613 | -0.6852 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.47437 | 94.13 | -5.615 | -1.009 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7016 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.207 | 1.356 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.47437</span> | 94.13 | 0.003644 | 0.2672 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.161 | 1.861 | 0.7016 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.207 | 1.356 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.431 | 0.8869 | -0.4735 | -0.05983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1554 | -4.492 | 3.189 | -0.6996 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.700 | -2.467 | -1.937 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 480.46651 | 1.002 | -1.216 | -0.9203 | -0.9000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5326 | -0.9537 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6240 | -0.7606 | -0.6847 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.46651 | 94.21 | -5.616 | -1.009 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7009 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.208 | 1.356 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.46651</span> | 94.21 | 0.003640 | 0.2672 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.161 | 1.861 | 0.7009 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.208 | 1.356 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.502 | 0.8860 | -0.4381 | -0.05035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1103 | -4.453 | 3.114 | 0.5384 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.770 | -2.407 | -1.897 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 480.45755 | 1.001 | -1.217 | -0.9200 | -0.9000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5325 | -0.9546 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6238 | -0.7600 | -0.6843 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.45755 | 94.13 | -5.617 | -1.009 | -0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7002 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.209 | 1.357 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.45755</span> | 94.13 | 0.003635 | 0.2673 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.861 | 0.7002 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.209 | 1.357 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.779 | 0.8798 | -0.4544 | -0.05816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1541 | -4.432 | 3.060 | 0.5236 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.719 | -2.365 | -1.874 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 480.44943 | 1.002 | -1.218 | -0.9199 | -0.9000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.5319 | -0.9555 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6235 | -0.7592 | -0.6838 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.44943 | 94.21 | -5.618 | -1.008 | -0.2046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.862 | 0.6995 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.209 | 1.357 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.44943</span> | 94.21 | 0.003631 | 0.2673 | 0.8149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.862 | 0.6995 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.209 | 1.357 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.806 | 0.8785 | -0.4202 | -0.05024 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1124 | -4.289 | 3.039 | 0.5974 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.651 | -2.322 | -1.843 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 480.44100 | 1.001 | -1.220 | -0.9197 | -0.9000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.5318 | -0.9564 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6233 | -0.7586 | -0.6835 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.441 | 94.13 | -5.620 | -1.008 | -0.2046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6988 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.210 | 1.358 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.441</span> | 94.13 | 0.003626 | 0.2673 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.862 | 0.6988 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.210 | 1.358 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.662 | 0.8724 | -0.4382 | -0.05735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1541 | -4.192 | 3.008 | 0.5718 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.633 | -2.283 | -1.828 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 480.43316 | 1.002 | -1.221 | -0.9195 | -0.9000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.5313 | -0.9573 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6230 | -0.7579 | -0.6830 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.43316 | 94.21 | -5.621 | -1.008 | -0.2046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6981 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.211 | 1.358 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.43316</span> | 94.21 | 0.003622 | 0.2674 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.862 | 0.6981 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.211 | 1.358 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.374 | 0.8709 | -0.4057 | -0.04981 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1077 | -4.274 | 2.898 | 0.5670 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.709 | -2.249 | -1.806 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 480.42514 | 1.001 | -1.222 | -0.9194 | -0.8999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.5312 | -0.9582 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6227 | -0.7573 | -0.6826 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.42514 | 94.13 | -5.622 | -1.008 | -0.2046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6974 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.212 | 1.359 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.42514</span> | 94.13 | 0.003617 | 0.2674 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.862 | 0.6974 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.212 | 1.359 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.560 | 0.8648 | -0.4238 | -0.05673 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1505 | -4.130 | 2.894 | 0.5588 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.637 | -2.210 | -1.785 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 480.41757 | 1.002 | -1.223 | -0.9192 | -0.8999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5307 | -0.9591 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6223 | -0.7566 | -0.6821 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.41757 | 94.21 | -5.623 | -1.008 | -0.2046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6967 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.212 | 1.359 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.41757</span> | 94.21 | 0.003613 | 0.2674 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.164 | 1.863 | 0.6967 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.212 | 1.359 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.260 | 0.8632 | -0.3905 | -0.04898 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1050 | -4.163 | 2.793 | 0.5626 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.680 | -2.170 | -1.767 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 480.40986 | 1.001 | -1.225 | -0.9190 | -0.8999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5306 | -0.9600 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6221 | -0.7560 | -0.6818 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.40986 | 94.13 | -5.625 | -1.008 | -0.2045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6961 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.213 | 1.360 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.40986</span> | 94.13 | 0.003607 | 0.2675 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.164 | 1.863 | 0.6961 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.213 | 1.360 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.433 | 0.8570 | -0.4082 | -0.05598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1439 | -4.083 | 2.776 | -0.7191 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.623 | -2.134 | -1.744 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 480.40309 | 1.002 | -1.226 | -0.9188 | -0.8999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8493 | -0.5301 | -0.9609 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6217 | -0.7553 | -0.6813 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.40309 | 94.20 | -5.626 | -1.007 | -0.2045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6954 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.214 | 1.360 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.40309</span> | 94.20 | 0.003603 | 0.2675 | 0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.165 | 1.863 | 0.6954 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.214 | 1.360 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.640 | 0.8551 | -0.3719 | -0.04853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1037 | -4.111 | 2.689 | 0.5674 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.653 | -2.095 | -1.726 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 480.39597 | 1.001 | -1.227 | -0.9185 | -0.8998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8492 | -0.5300 | -0.9618 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6215 | -0.7547 | -0.6809 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.39597 | 94.13 | -5.627 | -1.007 | -0.2045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6947 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.214 | 1.361 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.39597</span> | 94.13 | 0.003598 | 0.2676 | 0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.165 | 1.863 | 0.6947 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.214 | 1.361 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.827 | 0.8487 | -0.3865 | -0.05558 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1453 | -3.997 | 2.662 | 0.5449 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.580 | -2.061 | -1.701 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 480.38900 | 1.002 | -1.229 | -0.9184 | -0.8998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.5297 | -0.9626 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6211 | -0.7540 | -0.6805 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.389 | 94.20 | -5.629 | -1.007 | -0.2044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6940 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.215 | 1.361 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.389</span> | 94.20 | 0.003593 | 0.2676 | 0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.864 | 0.6940 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.215 | 1.361 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.052 | 0.8465 | -0.3544 | -0.04836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1022 | -3.917 | 2.636 | 0.5926 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.553 | -2.027 | -1.689 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 480.38219 | 1.001 | -1.230 | -0.9183 | -0.8998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.5296 | -0.9634 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6209 | -0.7534 | -0.6801 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.38219 | 94.13 | -5.630 | -1.007 | -0.2044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6934 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.216 | 1.362 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.38219</span> | 94.13 | 0.003587 | 0.2676 | 0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.864 | 0.6934 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.216 | 1.362 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.619 | 0.8406 | -0.3725 | -0.05439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1411 | -3.915 | 2.594 | -0.6808 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.519 | -1.986 | -1.659 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 480.37598 | 1.002 | -1.232 | -0.9180 | -0.8998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.5292 | -0.9644 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6206 | -0.7528 | -0.6796 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.37598 | 94.20 | -5.632 | -1.007 | -0.2044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6927 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.216 | 1.362 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.37598</span> | 94.20 | 0.003582 | 0.2677 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.864 | 0.6927 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.216 | 1.362 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.566 | 0.8383 | -0.3380 | -0.04700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09943 | -3.949 | 2.377 | 0.5751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.561 | -1.951 | -1.641 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 480.36982 | 1.001 | -1.233 | -0.9178 | -0.8997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5291 | -0.9651 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6204 | -0.7522 | -0.6792 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.36982 | 94.12 | -5.633 | -1.006 | -0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6922 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.217 | 1.363 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.36982</span> | 94.12 | 0.003577 | 0.2677 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.864 | 0.6922 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.217 | 1.363 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.243 | 0.8317 | -0.3515 | -0.05392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1358 | -3.830 | 2.493 | 0.5823 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.510 | -1.918 | -1.620 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 480.36331 | 1.002 | -1.235 | -0.9176 | -0.8997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5289 | -0.9659 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6201 | -0.7516 | -0.6788 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.36331 | 94.19 | -5.635 | -1.006 | -0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6916 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.218 | 1.363 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.36331</span> | 94.19 | 0.003572 | 0.2677 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.864 | 0.6916 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.218 | 1.363 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.492 | 0.8288 | -0.3226 | -0.04732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09956 | -3.829 | 2.435 | 0.5676 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.517 | -1.882 | -1.604 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 480.35731 | 1.001 | -1.236 | -0.9175 | -0.8996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.5288 | -0.9666 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6198 | -0.7510 | -0.6783 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.35731 | 94.12 | -5.636 | -1.006 | -0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6910 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.218 | 1.364 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.35731</span> | 94.12 | 0.003566 | 0.2678 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.864 | 0.6910 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.218 | 1.364 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.442 | 0.8230 | -0.3401 | -0.05270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1329 | -3.818 | 2.394 | -0.6865 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.462 | -1.826 | -1.568 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 480.35158 | 1.002 | -1.238 | -0.9173 | -0.8996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.5286 | -0.9675 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6197 | -0.7504 | -0.6779 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.35158 | 94.19 | -5.638 | -1.006 | -0.2042 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6904 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.219 | 1.364 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.35158</span> | 94.19 | 0.003561 | 0.2678 | 0.8153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.169 | 1.864 | 0.6904 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.219 | 1.364 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.119 | 0.8198 | -0.3066 | -0.04724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1005 | -3.787 | 2.338 | 0.5896 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.465 | -1.812 | -1.559 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 480.34603 | 1.001 | -1.239 | -0.9170 | -0.8996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8486 | -0.5283 | -0.9683 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.7499 | -0.6775 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.34603 | 94.12 | -5.639 | -1.006 | -0.2042 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.865 | 0.6897 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.220 | 1.364 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.34603</span> | 94.12 | 0.003555 | 0.2679 | 0.8153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.865 | 0.6897 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.220 | 1.364 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.669 | 0.8137 | -0.3182 | -0.05158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1292 | -3.845 | 2.251 | 0.5349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.532 | -1.781 | -1.537 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 480.33997 | 1.002 | -1.241 | -0.9169 | -0.8995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8486 | -0.5282 | -0.9690 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6192 | -0.7493 | -0.6772 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.33997 | 94.19 | -5.641 | -1.005 | -0.2041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6892 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.220 | 1.365 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.33997</span> | 94.19 | 0.003550 | 0.2679 | 0.8153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.865 | 0.6892 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.220 | 1.365 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.944 | 0.8109 | -0.2900 | -0.04418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09220 | -3.817 | 2.207 | 0.5423 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.530 | -1.750 | -1.524 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 480.33440 | 1.001 | -1.242 | -0.9168 | -0.8995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5280 | -0.9697 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6188 | -0.7487 | -0.6768 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.3344 | 94.12 | -5.642 | -1.005 | -0.2041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6887 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.485 | 1.221 | 1.365 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.3344</span> | 94.12 | 0.003544 | 0.2679 | 0.8154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.865 | 0.6887 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.485 | 1.221 | 1.365 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.630 | 0.8048 | -0.3070 | -0.04965 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1246 | -3.770 | 2.179 | 0.5400 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.465 | -1.710 | -1.500 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 480.32852 | 1.002 | -1.244 | -0.9167 | -0.8994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5278 | -0.9703 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6184 | -0.7482 | -0.6764 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.32852 | 94.19 | -5.644 | -1.005 | -0.2041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6882 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.485 | 1.221 | 1.366 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.32852</span> | 94.19 | 0.003538 | 0.2679 | 0.8154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.865 | 0.6882 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.485 | 1.221 | 1.366 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.819 | 0.8018 | -0.2789 | -0.04260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08823 | -3.653 | 2.177 | -0.6593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.384 | -1.678 | -1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 480.32382 | 1.001 | -1.246 | -0.9164 | -0.8994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8484 | -0.5276 | -0.9711 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6183 | -0.7477 | -0.6761 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.32382 | 94.12 | -5.646 | -1.005 | -0.2040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6876 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.222 | 1.366 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.32382</span> | 94.12 | 0.003533 | 0.2680 | 0.8155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.865 | 0.6876 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.222 | 1.366 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.225 | 0.7951 | -0.2896 | -0.04843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1194 | -3.720 | 2.091 | -0.7072 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.430 | -1.641 | -1.454 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 480.31902 | 1.002 | -1.247 | -0.9160 | -0.8993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8482 | -0.5273 | -0.9719 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6182 | -0.7473 | -0.6757 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.31902 | 94.19 | -5.647 | -1.005 | -0.2039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6870 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.222 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31902</span> | 94.19 | 0.003527 | 0.2681 | 0.8155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.173 | 1.865 | 0.6870 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.222 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.904 | 0.7922 | -0.2469 | -0.04034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08539 | -3.545 | 2.094 | -0.6237 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.331 | -1.619 | -1.454 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 480.31471 | 1.001 | -1.249 | -0.9156 | -0.8993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.5271 | -0.9727 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6181 | -0.7468 | -0.6753 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.31471 | 94.12 | -5.649 | -1.004 | -0.2039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6864 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.223 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31471</span> | 94.12 | 0.003522 | 0.2681 | 0.8156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 1.866 | 0.6864 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.223 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.295 | 0.7853 | -0.2507 | -0.04627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1126 | -3.760 | 1.942 | -0.7288 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.482 | -1.617 | -1.436 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 480.31013 | 1.002 | -1.250 | -0.9152 | -0.8992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8480 | -0.5269 | -0.9734 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6180 | -0.7464 | -0.6750 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.31013 | 94.19 | -5.650 | -1.004 | -0.2038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6859 | 0.7535 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.223 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31013</span> | 94.19 | 0.003516 | 0.2682 | 0.8156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.175 | 1.866 | 0.6859 | 0.7535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.223 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.435 | 0.7821 | -0.2118 | -0.03855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07590 | -3.495 | 2.000 | -0.6027 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.382 | -1.576 | -1.413 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 480.30581 | 1.001 | -1.252 | -0.9149 | -0.8991 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8479 | -0.5266 | -0.9741 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6178 | -0.7459 | -0.6746 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.30581 | 94.12 | -5.652 | -1.003 | -0.2037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6854 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.224 | 1.368 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.30581</span> | 94.12 | 0.003510 | 0.2683 | 0.8157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.176 | 1.866 | 0.6854 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.224 | 1.368 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.315 | 0.7789 | -0.2090 | -0.03720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09944 | -3.577 | 1.911 | -0.6518 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.378 | -1.528 | -1.376 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 480.30125 | 1.002 | -1.254 | -0.9146 | -0.8990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8478 | -0.5264 | -0.9748 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6176 | -0.7454 | -0.6743 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.30125 | 94.19 | -5.654 | -1.003 | -0.2037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6848 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.224 | 1.368 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.30125</span> | 94.19 | 0.003505 | 0.2683 | 0.8157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.177 | 1.866 | 0.6848 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.224 | 1.368 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.353 | 0.7723 | -0.1834 | -0.03622 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07047 | -3.672 | 1.822 | -0.6713 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.445 | -1.532 | -1.389 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 480.29714 | 1.001 | -1.255 | -0.9143 | -0.8990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5261 | -0.9754 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6174 | -0.7450 | -0.6740 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.29714 | 94.12 | -5.655 | -1.003 | -0.2036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6843 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.225 | 1.369 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.29714</span> | 94.12 | 0.003499 | 0.2684 | 0.8158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.178 | 1.866 | 0.6843 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.225 | 1.369 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.435 | 0.7663 | -0.1878 | -0.03986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1019 | -3.343 | 1.893 | 0.6711 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.269 | -1.487 | -1.354 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 480.29215 | 1.002 | -1.257 | -0.9143 | -0.8989 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5260 | -0.9760 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6172 | -0.7444 | -0.6736 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.29215 | 94.18 | -5.657 | -1.003 | -0.2036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6839 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.226 | 1.369 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.29215</span> | 94.18 | 0.003493 | 0.2684 | 0.8158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6839 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.226 | 1.369 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.161 | 0.7621 | -0.1686 | -0.03452 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06632 | -3.552 | 1.775 | 0.6057 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.379 | -1.473 | -1.364 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 480.28721 | 1.001 | -1.259 | -0.9145 | -0.8989 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5257 | -0.9765 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6170 | -0.7439 | -0.6732 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.28721 | 94.12 | -5.659 | -1.003 | -0.2035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6836 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.226 | 1.369 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.28721</span> | 94.12 | 0.003487 | 0.2684 | 0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6836 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.226 | 1.369 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.925 | 0.7584 | -0.1913 | -0.03513 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09132 | -3.418 | 1.781 | -0.6203 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.349 | -1.417 | -1.313 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 480.28278 | 1.002 | -1.260 | -0.9144 | -0.8988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8475 | -0.5255 | -0.9770 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6167 | -0.7434 | -0.6728 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.28278 | 94.19 | -5.660 | -1.003 | -0.2035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6832 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.227 | 1.370 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.28278</span> | 94.19 | 0.003481 | 0.2684 | 0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6832 | 0.7537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.227 | 1.370 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.442 | 0.7524 | -0.1734 | -0.03276 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06267 | -3.400 | 1.746 | -0.5960 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.307 | -1.411 | -1.323 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 480.27897 | 1.001 | -1.262 | -0.9141 | -0.8988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8474 | -0.5252 | -0.9776 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6165 | -0.7431 | -0.6724 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.27897 | 94.13 | -5.662 | -1.003 | -0.2034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6827 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.227 | 1.370 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.27897</span> | 94.13 | 0.003475 | 0.2684 | 0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.180 | 1.867 | 0.6827 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.227 | 1.370 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.732 | 0.7463 | -0.1764 | -0.03625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08933 | -3.375 | 1.716 | 0.6486 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.273 | -1.374 | -1.283 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 480.27440 | 1.002 | -1.264 | -0.9140 | -0.8987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8473 | -0.5250 | -0.9782 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6164 | -0.7427 | -0.6721 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.2744 | 94.19 | -5.664 | -1.003 | -0.2034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6823 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.227 | 1.371 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2744</span> | 94.19 | 0.003469 | 0.2684 | 0.8160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.181 | 1.867 | 0.6823 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.227 | 1.371 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.305 | 0.7431 | -0.1535 | -0.02884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05624 | -3.424 | 1.641 | -0.6166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.366 | -1.368 | -1.291 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 480.27043 | 1.001 | -1.266 | -0.9140 | -0.8987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8473 | -0.5247 | -0.9786 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6161 | -0.7423 | -0.6718 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.27043 | 94.13 | -5.666 | -1.002 | -0.2033 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6819 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.228 | 1.371 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.27043</span> | 94.13 | 0.003463 | 0.2685 | 0.8160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.181 | 1.868 | 0.6819 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.228 | 1.371 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.306 | 0.7372 | -0.1665 | -0.03186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08221 | -3.333 | 1.631 | -0.6040 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.265 | -1.322 | -1.255 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 480.26665 | 1.002 | -1.267 | -0.9136 | -0.8986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.5244 | -0.9791 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6160 | -0.7419 | -0.6714 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.26665 | 94.19 | -5.667 | -1.002 | -0.2032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6815 | 0.7540 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.228 | 1.371 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.26665</span> | 94.19 | 0.003457 | 0.2685 | 0.8161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.182 | 1.868 | 0.6815 | 0.7540 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.228 | 1.371 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.654 | 0.7327 | -0.1326 | -0.02617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04981 | -3.394 | 1.559 | -0.6139 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.358 | -1.341 | -1.268 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 480.26300 | 1.001 | -1.269 | -0.9132 | -0.8985 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8470 | -0.5241 | -0.9796 | -1.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6158 | -0.7416 | -0.6711 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.263 | 94.13 | -5.669 | -1.002 | -0.2032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6812 | 0.7542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.229 | 1.372 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.263</span> | 94.13 | 0.003451 | 0.2686 | 0.8162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.183 | 1.868 | 0.6812 | 0.7542 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.229 | 1.372 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.009 | 0.7258 | -0.1343 | -0.03035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07619 | -3.164 | 1.609 | -0.5397 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.251 | -1.282 | -1.219 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 480.25930 | 1.002 | -1.271 | -0.9130 | -0.8985 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5239 | -0.9802 | -1.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6155 | -0.7412 | -0.6708 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.2593 | 94.19 | -5.671 | -1.002 | -0.2031 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6807 | 0.7543 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 1.229 | 1.372 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2593</span> | 94.19 | 0.003445 | 0.2686 | 0.8162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.868 | 0.6807 | 0.7543 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.489 | 1.229 | 1.372 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.851 | 0.7223 | -0.1045 | -0.02290 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04316 | -3.376 | 1.478 | 0.6193 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.343 | -1.302 | -1.232 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 480.25486 | 1.001 | -1.273 | -0.9131 | -0.8984 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5237 | -0.9805 | -1.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6152 | -0.7408 | -0.6705 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.25486 | 94.14 | -5.673 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6805 | 0.7542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 1.230 | 1.373 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.25486</span> | 94.14 | 0.003439 | 0.2686 | 0.8162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.868 | 0.6805 | 0.7542 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.489 | 1.230 | 1.373 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.282 | 0.7167 | -0.1236 | -0.02586 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06793 | -3.294 | 1.470 | 0.6693 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.247 | -1.242 | -1.194 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 480.25000 | 1.002 | -1.274 | -0.9134 | -0.8984 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5231 | -0.9806 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6147 | -0.7402 | -0.6701 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.25 | 94.20 | -5.674 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6804 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.230 | 1.373 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.25</span> | 94.20 | 0.003434 | 0.2686 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6804 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.230 | 1.373 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.823 | 0.7134 | -0.1173 | -0.02040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04062 | -3.151 | 1.491 | -0.5685 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.243 | -1.237 | -1.210 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 480.24598 | 1.001 | -1.276 | -0.9134 | -0.8984 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5229 | -0.9809 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6145 | -0.7399 | -0.6698 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.24598 | 94.13 | -5.676 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6802 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.231 | 1.373 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.24598</span> | 94.13 | 0.003427 | 0.2686 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6802 | 0.7539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.231 | 1.373 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.294 | 0.7076 | -0.1362 | -0.02383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06566 | -3.147 | 1.461 | 0.6663 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.244 | -1.185 | -1.155 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 480.24152 | 1.002 | -1.278 | -0.9134 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5225 | -0.9813 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6142 | -0.7395 | -0.6694 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.24152 | 94.19 | -5.678 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6799 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.231 | 1.374 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.24152</span> | 94.19 | 0.003421 | 0.2686 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6799 | 0.7538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.231 | 1.374 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.573 | 0.7031 | -0.1214 | -0.01999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04022 | -3.129 | 1.425 | 0.6287 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.274 | -1.197 | -1.174 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 480.23703 | 1.001 | -1.280 | -0.9136 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5223 | -0.9815 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6136 | -0.7392 | -0.6691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.23703 | 94.13 | -5.680 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6797 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 1.231 | 1.374 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23703</span> | 94.13 | 0.003415 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6797 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.491 | 1.231 | 1.374 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.496 | 0.6977 | -0.1464 | -0.02500 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06997 | -3.031 | 1.316 | 0.6455 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.198 | -1.144 | -1.124 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 480.23246 | 1.002 | -1.281 | -0.9138 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5219 | -0.9816 | -1.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6131 | -0.7387 | -0.6687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.23246 | 94.19 | -5.681 | -1.002 | -0.2030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6796 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23246</span> | 94.19 | 0.003409 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6796 | 0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.825 | 0.6940 | -0.1347 | -0.01919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03939 | -3.118 | 1.378 | 0.5922 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.219 | -1.136 | -1.127 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 480.22809 | 1.001 | -1.283 | -0.9138 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5217 | -0.9816 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6127 | -0.7384 | -0.6684 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.22809 | 94.14 | -5.683 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6796 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22809</span> | 94.14 | 0.003403 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6796 | 0.7531 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.001 | 0.6885 | -0.1518 | -0.02256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06414 | -2.892 | 1.443 | 0.6415 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -1.098 | -1.101 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 480.22387 | 1.002 | -1.285 | -0.9139 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5212 | -0.9821 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6124 | -0.7381 | -0.6680 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.22387 | 94.19 | -5.685 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6793 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22387</span> | 94.19 | 0.003397 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6793 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.360 | 0.6846 | -0.1392 | -0.01938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04006 | -2.853 | 1.421 | -0.5715 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -1.117 | -1.118 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 480.22054 | 1.001 | -1.287 | -0.9139 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5210 | -0.9826 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6125 | -0.7380 | -0.6676 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.22054 | 94.14 | -5.687 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6789 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.233 | 1.376 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22054</span> | 94.14 | 0.003391 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6789 | 0.7530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.233 | 1.376 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.774 | 0.6781 | -0.1521 | -0.02419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06697 | -2.800 | 1.392 | 0.6467 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.111 | -1.074 | -1.064 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 480.21670 | 1.002 | -1.288 | -0.9138 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5206 | -0.9832 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6123 | -0.7378 | -0.6672 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.2167 | 94.19 | -5.688 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6784 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 1.233 | 1.376 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2167</span> | 94.19 | 0.003385 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6784 | 0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.493 | 1.233 | 1.376 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.519 | 0.6730 | -0.1351 | -0.02088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04118 | -2.856 | 1.311 | 0.6094 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.165 | -1.062 | -1.048 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 480.21269 | 1.001 | -1.290 | -0.9139 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5205 | -0.9835 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6119 | -0.7376 | -0.6670 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.21269 | 94.14 | -5.690 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6782 | 0.7527 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 1.233 | 1.377 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.21269</span> | 94.14 | 0.003379 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6782 | 0.7527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.493 | 1.233 | 1.377 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.933 | 0.6686 | -0.1517 | -0.01805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06304 | -2.806 | 1.298 | 0.6045 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.073 | -1.045 | -1.026 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 480.20865 | 1.002 | -1.292 | -0.9139 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5201 | -0.9839 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6115 | -0.7373 | -0.6667 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.20865 | 94.19 | -5.692 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6779 | 0.7525 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.233 | 1.377 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20865</span> | 94.19 | 0.003373 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6779 | 0.7525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.233 | 1.377 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.802 | 0.6647 | -0.1367 | -0.01906 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03994 | -2.699 | 1.311 | -0.5807 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.078 | -1.030 | -1.030 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 480.20558 | 1.001 | -1.294 | -0.9137 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8468 | -0.5199 | -0.9842 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6113 | -0.7372 | -0.6665 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.20558 | 94.14 | -5.694 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6776 | 0.7525 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.233 | 1.377 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20558</span> | 94.14 | 0.003367 | 0.2685 | 0.8163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.185 | 1.871 | 0.6776 | 0.7525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.233 | 1.377 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.911 | 0.6576 | -0.1438 | -0.02051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06613 | -2.751 | 1.246 | -0.6218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -1.017 | -1.010 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 480.20291 | 1.002 | -1.296 | -0.9132 | -0.8982 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.5195 | -0.9848 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6112 | -0.7370 | -0.6662 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.20291 | 94.19 | -5.696 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.872 | 0.6772 | 0.7527 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.377 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20291</span> | 94.19 | 0.003361 | 0.2686 | 0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 1.872 | 0.6772 | 0.7527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.377 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.296 | 0.6533 | -0.1055 | -0.01383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03435 | -2.750 | 1.192 | -0.6155 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.121 | -1.037 | -1.054 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 480.20010 | 1.001 | -1.297 | -0.9127 | -0.8982 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5193 | -0.9850 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6110 | -0.7368 | -0.6658 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.2001 | 94.14 | -5.697 | -1.001 | -0.2028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6771 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.378 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2001</span> | 94.14 | 0.003355 | 0.2687 | 0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6771 | 0.7528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.378 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.841 | 0.6461 | -0.09617 | -0.01892 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05600 | -2.503 | 1.255 | 0.6797 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9587 | -1.006 | -0.9794 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 480.19652 | 1.002 | -1.299 | -0.9127 | -0.8982 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5191 | -0.9853 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6108 | -0.7364 | -0.6653 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.19652 | 94.19 | -5.699 | -1.001 | -0.2028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6768 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.378 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.19652</span> | 94.19 | 0.003349 | 0.2687 | 0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6768 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.378 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 480.19461 | 1.002 | -1.301 | -0.9128 | -0.8982 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5193 | -0.9855 | -1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6107 | -0.7361 | -0.6650 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.19461 | 94.18 | -5.701 | -1.001 | -0.2028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6767 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.235 | 1.379 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.19461</span> | 94.18 | 0.003342 | 0.2687 | 0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6767 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.235 | 1.379 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 480.18441 | 1.002 | -1.313 | -0.9134 | -0.8983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5209 | -0.9862 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6104 | -0.7344 | -0.6628 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.18441 | 94.17 | -5.713 | -1.002 | -0.2029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.871 | 0.6762 | 0.7522 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 1.237 | 1.381 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.18441</span> | 94.17 | 0.003303 | 0.2686 | 0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.871 | 0.6762 | 0.7522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.495 | 1.237 | 1.381 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 480.15712 | 1.001 | -1.360 | -0.9157 | -0.8984 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5271 | -0.9890 | -1.004 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6089 | -0.7277 | -0.6540 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.15712 | 94.12 | -5.760 | -1.004 | -0.2031 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.866 | 0.6740 | 0.7509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 1.244 | 1.391 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.15712</span> | 94.12 | 0.003151 | 0.2681 | 0.8162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.866 | 0.6740 | 0.7509 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.497 | 1.244 | 1.391 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 480.23418 | 0.9997 | -1.543 | -0.9246 | -0.8991 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8465 | -0.5509 | -1.000 | -1.011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6032 | -0.7017 | -0.6198 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.23418 | 93.97 | -5.943 | -1.013 | -0.2037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.847 | 0.6655 | 0.7454 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.503 | 1.272 | 1.431 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23418</span> | 93.97 | 0.002624 | 0.2664 | 0.8157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.847 | 0.6655 | 0.7454 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.503 | 1.272 | 1.431 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.048 | 0.4781 | -0.2230 | -0.02217 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05480 | -3.577 | 0.9301 | 0.6494 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.028 | -0.4525 | -0.4232 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 480.10748 | 1.002 | -1.612 | -0.8919 | -0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8419 | -0.5057 | -1.005 | -1.011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6089 | -0.7402 | -0.6757 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.10748 | 94.20 | -6.012 | -0.9804 | -0.2001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.107 | 1.883 | 0.6618 | 0.7449 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 1.230 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.10748</span> | 94.20 | 0.002450 | 0.2728 | 0.8186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.225 | 1.883 | 0.6618 | 0.7449 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.497 | 1.230 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.588 | -0.2032 | 1.050 | 0.05863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1556 | -1.013 | -0.1797 | 0.1430 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -1.192 | -1.504 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 480.44664 | 1.003 | -1.804 | -0.9880 | -0.8940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8524 | -0.4601 | -0.9127 | -1.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5485 | -0.7099 | -0.6226 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.44664 | 94.31 | -6.204 | -1.077 | -0.1987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.097 | 1.919 | 0.7320 | 0.7196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 1.263 | 1.427 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.44664</span> | 94.31 | 0.002022 | 0.2542 | 0.8198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.139 | 1.919 | 0.7320 | 0.7196 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.568 | 1.263 | 1.427 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 480.05051 | 1.002 | -1.657 | -0.9147 | -0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8444 | -0.4949 | -0.9832 | -1.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5946 | -0.7329 | -0.6630 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.05051 | 94.19 | -6.057 | -1.003 | -0.1998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.105 | 1.891 | 0.6784 | 0.7389 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.514 | 1.238 | 1.381 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.05051</span> | 94.19 | 0.002341 | 0.2683 | 0.8189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.205 | 1.891 | 0.6784 | 0.7389 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.514 | 1.238 | 1.381 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.048 | -0.2764 | -0.02525 | 0.07726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1002 | 0.1555 | 1.072 | 0.1458 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5013 | -0.7465 | -0.9442 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 480.05873 | 1.002 | -1.641 | -0.9145 | -0.9051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8597 | -0.5017 | -0.9961 | -1.019 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5552 | -0.7600 | -0.6392 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.05873 | 94.21 | -6.041 | -1.003 | -0.2097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.089 | 1.886 | 0.6686 | 0.7381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.561 | 1.209 | 1.408 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.05873</span> | 94.21 | 0.002380 | 0.2684 | 0.8108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.080 | 1.886 | 0.6686 | 0.7381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.561 | 1.209 | 1.408 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 480.03299 | 1.002 | -1.650 | -0.9146 | -0.8993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8508 | -0.4977 | -0.9887 | -1.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5780 | -0.7442 | -0.6529 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.03299 | 94.17 | -6.050 | -1.003 | -0.2040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.098 | 1.889 | 0.6742 | 0.7386 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.533 | 1.226 | 1.393 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.03299</span> | 94.17 | 0.002357 | 0.2683 | 0.8155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.152 | 1.889 | 0.6742 | 0.7386 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.533 | 1.226 | 1.393 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.07884 | -0.2508 | -0.03233 | -0.02314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1302 | 0.06288 | 0.7629 | 0.2261 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3850 | -1.277 | -0.6610 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 480.00970 | 1.003 | -1.641 | -0.9125 | -0.9005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4980 | -0.9983 | -1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5841 | -0.7275 | -0.6414 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.0097 | 94.26 | -6.041 | -1.001 | -0.2051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6670 | 0.7367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.244 | 1.406 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.0097</span> | 94.26 | 0.002380 | 0.2687 | 0.8145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6670 | 0.7367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.244 | 1.406 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.51 | -0.2151 | 0.1066 | -0.04414 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06212 | -0.2557 | 0.09002 | -0.09728 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.06582 | -0.3883 | 0.07016 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 480.02569 | 1.000 | -1.627 | -0.9257 | -0.9015 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.4974 | -1.010 | -1.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5876 | -0.7200 | -0.6493 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.02569 | 94.03 | -6.027 | -1.014 | -0.2061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6581 | 0.7348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.522 | 1.252 | 1.397 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.02569</span> | 94.03 | 0.002413 | 0.2662 | 0.8138 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.889 | 0.6581 | 0.7348 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.522 | 1.252 | 1.397 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 480.01783 | 1.000 | -1.636 | -0.9171 | -0.9008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.4978 | -1.002 | -1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5853 | -0.7249 | -0.6441 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.01783 | 94.03 | -6.036 | -1.006 | -0.2055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6639 | 0.7361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.525 | 1.247 | 1.403 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.01783</span> | 94.03 | 0.002392 | 0.2678 | 0.8143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.889 | 0.6639 | 0.7361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.525 | 1.247 | 1.403 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 480.01762 | 1.000 | -1.639 | -0.9140 | -0.9006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4979 | -0.9995 | -1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5844 | -0.7266 | -0.6422 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.01762 | 94.04 | -6.039 | -1.002 | -0.2052 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6660 | 0.7365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.245 | 1.405 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.01762</span> | 94.04 | 0.002384 | 0.2685 | 0.8145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6660 | 0.7365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.245 | 1.405 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 480.00603 | 1.001 | -1.641 | -0.9125 | -0.9005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4980 | -0.9983 | -1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5841 | -0.7275 | -0.6414 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.00603 | 94.12 | -6.041 | -1.001 | -0.2051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6670 | 0.7367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.244 | 1.406 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00603</span> | 94.12 | 0.002380 | 0.2687 | 0.8145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6670 | 0.7367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.244 | 1.406 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.885 | -0.2187 | 0.06031 | -0.05864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1316 | -0.6942 | -0.07940 | 0.7419 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2628 | -0.6303 | -0.1748 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 480.00355 | 1.002 | -1.640 | -0.9125 | -0.9004 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.4981 | -0.9983 | -1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5835 | -0.7267 | -0.6420 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.00355 | 94.17 | -6.040 | -1.001 | -0.2050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6669 | 0.7366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.527 | 1.245 | 1.405 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00355</span> | 94.17 | 0.002382 | 0.2687 | 0.8147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.889 | 0.6669 | 0.7366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.245 | 1.405 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1332 | -0.2152 | 0.07761 | -0.04946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09731 | -0.07704 | 0.1258 | 0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.08309 | -0.3432 | 0.03979 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 480.00003 | 1.002 | -1.640 | -0.9126 | -0.9003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.4980 | -0.9985 | -1.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5836 | -0.7262 | -0.6420 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.00003 | 94.19 | -6.040 | -1.001 | -0.2049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.889 | 0.6668 | 0.7355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.527 | 1.245 | 1.405 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00003</span> | 94.19 | 0.002382 | 0.2687 | 0.8147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.889 | 0.6668 | 0.7355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.245 | 1.405 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.294 | -0.2073 | 0.08146 | -0.04541 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07807 | -0.2293 | 0.05730 | 0.8075 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.008164 | -0.3171 | 0.03808 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 479.99578 | 1.002 | -1.638 | -0.9109 | -0.8997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8483 | -0.4984 | -0.9975 | -1.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5809 | -0.7230 | -0.6440 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.99578 | 94.17 | -6.038 | -0.9994 | -0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.889 | 0.6675 | 0.7343 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.530 | 1.249 | 1.403 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.99578</span> | 94.17 | 0.002387 | 0.2691 | 0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.889 | 0.6675 | 0.7343 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.530 | 1.249 | 1.403 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 479.99301 | 1.002 | -1.632 | -0.9055 | -0.8980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8447 | -0.4999 | -0.9947 | -1.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5728 | -0.7134 | -0.6498 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.99301 | 94.16 | -6.032 | -0.9941 | -0.2026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.104 | 1.887 | 0.6697 | 0.7310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.540 | 1.259 | 1.396 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.99301</span> | 94.16 | 0.002402 | 0.2701 | 0.8166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.202 | 1.887 | 0.6697 | 0.7310 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.540 | 1.259 | 1.396 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5972 | -0.1625 | 0.4650 | 0.009686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08636 | -1.694 | -0.1652 | -1.042 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1517 | 0.4204 | -0.3659 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 479.98697 | 1.002 | -1.611 | -0.9101 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8385 | -0.4966 | -0.9980 | -1.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5750 | -0.7140 | -0.6459 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.98697 | 94.17 | -6.011 | -0.9986 | -0.1991 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.111 | 1.890 | 0.6672 | 0.7309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.537 | 1.259 | 1.401 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.98697</span> | 94.17 | 0.002451 | 0.2692 | 0.8195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.253 | 1.890 | 0.6672 | 0.7309 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.537 | 1.259 | 1.401 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.005684 | -0.1115 | 0.2082 | 0.08938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3008 | 0.01411 | 0.1052 | -0.7061 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.4111 | 0.4010 | -0.1199 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 479.98697 | 1.002 | -1.611 | -0.9101 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8385 | -0.4966 | -0.9980 | -1.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5750 | -0.7140 | -0.6459 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.98697 | 94.17 | -6.011 | -0.9986 | -0.1991 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.111 | 1.890 | 0.6672 | 0.7309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.537 | 1.259 | 1.401 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.98697</span> | 94.17 | 0.002451 | 0.2692 | 0.8195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.253 | 1.890 | 0.6672 | 0.7309 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.537 | 1.259 | 1.401 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma | o1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o6 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 517.20934 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 517.20934 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 517.20934</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 64.43 | 1.648 | -0.07882 | -0.2050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4304 | 0.05992 | -56.51 | 17.73 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.983 | -11.00 | -3.771 | 3.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.58 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2737.3115 | 0.2806 | -1.018 | -0.9100 | -0.9273 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9731 | -0.8892 | -0.2282 | -1.075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9854 | -0.7447 | -0.8291 | -0.9136 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7499 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 2737.3115 | 26.38 | -5.418 | -0.9691 | -1.898 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.295 | 0.1399 | 2.105 | 0.5864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 1.329 | 1.042 | 0.8535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2737.3115</span> | 26.38 | 0.004434 | 0.2751 | 0.1499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01363 | 0.5349 | 2.105 | 0.5864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 1.329 | 1.042 | 0.8535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 569.57476 | 0.9281 | -1.002 | -0.9108 | -0.9293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9774 | -0.8886 | -0.7961 | -0.8964 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8851 | -0.8553 | -0.8670 | -0.8775 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8562 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 569.57476 | 87.24 | -5.402 | -0.9699 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.650 | 0.7166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8537 | 1.198 | 1.004 | 0.8856 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.175 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 569.57476</span> | 87.24 | 0.004508 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01358 | 0.5349 | 1.650 | 0.7166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8537 | 1.198 | 1.004 | 0.8856 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.175 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 531.41065 | 0.9928 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9778 | -0.8885 | -0.8528 | -0.8786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8751 | -0.8663 | -0.8708 | -0.8739 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8668 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.41065 | 93.32 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.605 | 0.7297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8624 | 1.185 | 1.000 | 0.8888 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.163 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.41065</span> | 93.32 | 0.004516 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.605 | 0.7297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8624 | 1.185 | 1.000 | 0.8888 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.163 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 531.74000 | 0.9993 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8585 | -0.8768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8741 | -0.8674 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8679 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.74 | 93.93 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.601 | 0.7310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8632 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.74</span> | 93.93 | 0.004516 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.601 | 0.7310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8632 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 531.81753 | 0.9999 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8591 | -0.8767 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.81753 | 93.99 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.81753</span> | 93.99 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 531.82573 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8591 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82573 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82573</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 531.82668 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82668 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82668</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 531.82678 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82678 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82678</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 531.82678 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82678 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82678</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance, can check sandwich or S matrix with $covRS and $covS</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Variance by variable is supported by 'saem' and 'focei'</span></span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_saem_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> 1: 93.4067 -5.7935 -0.0604 2.2993 -1.1624 2.9450 1.7342 0.6650 0.5890 0.4750 14.5215 9.1023</span> +<span class="r-out co"><span class="r-pr">#></span> 2: 93.8811 -5.7873 -0.0289 2.3640 -1.0762 2.7977 2.0710 0.6317 0.5595 0.4512 11.1033 4.6425</span> +<span class="r-out co"><span class="r-pr">#></span> 3: 94.0397 -5.9934 0.0119 2.4035 -1.0703 3.0693 2.4524 0.6124 0.5316 0.4287 10.0698 3.4243</span> +<span class="r-out co"><span class="r-pr">#></span> 4: 93.8834 -6.0401 0.0041 2.3944 -1.0097 2.9159 3.1645 0.6120 0.5050 0.4073 9.2013 3.2162</span> +<span class="r-out co"><span class="r-pr">#></span> 5: 94.0163 -5.8381 -0.0267 2.3580 -1.0239 2.7701 3.0063 0.5814 0.4797 0.3869 9.0330 3.0330</span> +<span class="r-out co"><span class="r-pr">#></span> 6: 93.9753 -5.8371 -0.0315 2.3598 -1.0052 2.6316 2.8559 0.5708 0.4558 0.3675 8.6051 2.6518</span> +<span class="r-out co"><span class="r-pr">#></span> 7: 93.6109 -5.8741 -0.0401 2.3570 -1.0025 2.5000 2.7131 0.5691 0.4330 0.3492 8.4407 2.4701</span> +<span class="r-out co"><span class="r-pr">#></span> 8: 93.2480 -6.0361 -0.0523 2.3504 -1.0028 2.3750 3.1584 0.5407 0.4113 0.3317 8.6121 2.2437</span> +<span class="r-out co"><span class="r-pr">#></span> 9: 93.2245 -6.0431 -0.0503 2.3552 -0.9828 2.2562 3.9790 0.5395 0.3908 0.3151 8.6609 2.1129</span> +<span class="r-out co"><span class="r-pr">#></span> 10: 93.3040 -6.1080 -0.0503 2.3613 -0.9784 2.1434 4.8606 0.5401 0.3712 0.2994 8.6497 2.0865</span> +<span class="r-out co"><span class="r-pr">#></span> 11: 93.4509 -5.9532 -0.0503 2.3444 -0.9823 3.0948 4.6176 0.5679 0.3527 0.2844 8.1651 2.0310</span> +<span class="r-out co"><span class="r-pr">#></span> 12: 93.5099 -6.1699 -0.0503 2.3408 -0.9746 3.2814 4.3867 0.5679 0.3350 0.2702 8.1716 1.9862</span> +<span class="r-out co"><span class="r-pr">#></span> 13: 93.8052 -6.1984 -0.0474 2.3233 -0.9922 3.1173 4.6967 0.5644 0.3183 0.2567 8.2982 2.0040</span> +<span class="r-out co"><span class="r-pr">#></span> 14: 93.6510 -6.0090 -0.0429 2.3601 -0.9885 2.9615 4.4618 0.5526 0.3024 0.2438 8.3254 2.0605</span> +<span class="r-out co"><span class="r-pr">#></span> 15: 93.8952 -6.3354 -0.0394 2.3580 -0.9792 2.8134 5.2117 0.5657 0.2872 0.2316 8.1329 2.0520</span> +<span class="r-out co"><span class="r-pr">#></span> 16: 93.4703 -6.0722 -0.0434 2.3386 -1.0026 2.6727 4.9512 0.5781 0.2729 0.2201 8.0866 2.0994</span> +<span class="r-out co"><span class="r-pr">#></span> 17: 93.4238 -6.2132 -0.0755 2.3120 -1.0119 2.5391 4.7036 0.5495 0.2592 0.2091 7.5958 2.2864</span> +<span class="r-out co"><span class="r-pr">#></span> 18: 93.5288 -6.2747 -0.0616 2.3223 -1.0105 2.4121 4.4684 0.5467 0.2463 0.1986 7.1910 1.9828</span> +<span class="r-out co"><span class="r-pr">#></span> 19: 93.2607 -6.3635 -0.0631 2.3206 -1.0045 3.6271 4.8142 0.5405 0.2340 0.1928 7.3672 1.8187</span> +<span class="r-out co"><span class="r-pr">#></span> 20: 93.3918 -6.3241 -0.0742 2.2941 -1.0140 3.4457 4.9242 0.5596 0.2223 0.1950 7.1427 1.8754</span> +<span class="r-out co"><span class="r-pr">#></span> 21: 93.6794 -6.1336 -0.0758 2.3000 -1.0048 3.2734 4.6780 0.5565 0.2111 0.1852 7.0989 1.9232</span> +<span class="r-out co"><span class="r-pr">#></span> 22: 94.0006 -6.1882 -0.0800 2.3099 -1.0252 3.1098 4.4441 0.5354 0.2006 0.1870 7.0038 1.9920</span> +<span class="r-out co"><span class="r-pr">#></span> 23: 93.6433 -6.2626 -0.0841 2.2791 -1.0183 4.8893 4.4476 0.5276 0.1906 0.1798 6.3698 1.8787</span> +<span class="r-out co"><span class="r-pr">#></span> 24: 93.9545 -6.3772 -0.0816 2.2887 -1.0019 4.6448 5.1698 0.5293 0.1810 0.1779 6.5903 1.9474</span> +<span class="r-out co"><span class="r-pr">#></span> 25: 94.2280 -6.3235 -0.0839 2.2600 -0.9932 5.2801 4.9113 0.5262 0.1720 0.1806 6.5267 1.9807</span> +<span class="r-out co"><span class="r-pr">#></span> 26: 94.2022 -6.2830 -0.0883 2.2643 -1.0012 5.9595 4.6658 0.5225 0.1634 0.1795 6.3678 1.9659</span> +<span class="r-out co"><span class="r-pr">#></span> 27: 94.4398 -6.1769 -0.0894 2.2564 -1.0177 9.0771 4.4325 0.5207 0.1552 0.1880 6.4522 1.8590</span> +<span class="r-out co"><span class="r-pr">#></span> 28: 94.2586 -6.1652 -0.0882 2.2574 -1.0226 8.6233 4.2108 0.5158 0.1475 0.1881 6.3701 1.7882</span> +<span class="r-out co"><span class="r-pr">#></span> 29: 94.3490 -6.1505 -0.0854 2.2615 -1.0081 9.6333 4.0003 0.5109 0.1423 0.1833 6.3601 1.8485</span> +<span class="r-out co"><span class="r-pr">#></span> 30: 94.6929 -6.0285 -0.0909 2.2610 -1.0082 9.1517 3.8003 0.5117 0.1401 0.2097 6.2461 1.8606</span> +<span class="r-out co"><span class="r-pr">#></span> 31: 94.2553 -6.0390 -0.0896 2.2625 -1.0078 8.6941 3.6103 0.5072 0.1378 0.2088 6.3337 1.8220</span> +<span class="r-out co"><span class="r-pr">#></span> 32: 94.3096 -5.7252 -0.0886 2.2677 -0.9967 9.0244 3.4298 0.5051 0.1325 0.2015 6.4601 1.8880</span> +<span class="r-out co"><span class="r-pr">#></span> 33: 94.8327 -5.8775 -0.0865 2.2684 -0.9976 8.6305 3.2583 0.4920 0.1333 0.1993 6.4804 1.8203</span> +<span class="r-out co"><span class="r-pr">#></span> 34: 94.3527 -5.9488 -0.0826 2.2879 -0.9989 8.1989 3.1538 0.4969 0.1388 0.1984 6.4201 1.7696</span> +<span class="r-out co"><span class="r-pr">#></span> 35: 94.4411 -6.1171 -0.0826 2.2913 -0.9964 8.4377 3.7937 0.4969 0.1387 0.1972 6.3878 1.7612</span> +<span class="r-out co"><span class="r-pr">#></span> 36: 94.2058 -6.1151 -0.0844 2.2920 -1.0069 8.0158 3.7963 0.4962 0.1395 0.1938 6.2469 1.6680</span> +<span class="r-out co"><span class="r-pr">#></span> 37: 93.7449 -6.1251 -0.0925 2.2736 -1.0019 7.6150 3.8477 0.5101 0.1325 0.1841 6.1375 1.7472</span> +<span class="r-out co"><span class="r-pr">#></span> 38: 93.6861 -6.0575 -0.0934 2.2803 -1.0097 7.2343 3.6553 0.5119 0.1259 0.1862 6.0729 1.7608</span> +<span class="r-out co"><span class="r-pr">#></span> 39: 93.9767 -6.0314 -0.0999 2.2548 -1.0231 6.8726 3.4725 0.5195 0.1234 0.1951 6.1947 1.8276</span> +<span class="r-out co"><span class="r-pr">#></span> 40: 94.0297 -6.1559 -0.0989 2.2440 -1.0374 6.5290 3.8559 0.5199 0.1279 0.1891 6.0195 1.8906</span> +<span class="r-out co"><span class="r-pr">#></span> 41: 94.2069 -6.3055 -0.0820 2.2710 -1.0275 6.2025 4.7866 0.5304 0.1215 0.1858 6.1777 1.8541</span> +<span class="r-out co"><span class="r-pr">#></span> 42: 94.2400 -6.3179 -0.0790 2.2783 -1.0379 5.8924 4.6915 0.5253 0.1154 0.1794 6.0530 1.8960</span> +<span class="r-out co"><span class="r-pr">#></span> 43: 93.9851 -6.4096 -0.0784 2.2832 -1.0341 5.5978 5.0608 0.5163 0.1097 0.1773 6.0057 1.8136</span> +<span class="r-out co"><span class="r-pr">#></span> 44: 94.1440 -6.2214 -0.0746 2.2969 -1.0262 5.3179 4.8077 0.5130 0.1079 0.1851 6.1182 1.8390</span> +<span class="r-out co"><span class="r-pr">#></span> 45: 93.8847 -6.3883 -0.0745 2.3059 -1.0132 6.8202 5.1378 0.5130 0.1174 0.1769 6.1000 1.8391</span> +<span class="r-out co"><span class="r-pr">#></span> 46: 93.7228 -6.3305 -0.0794 2.3033 -1.0107 6.4792 4.8809 0.5095 0.1196 0.1783 6.2794 1.7304</span> +<span class="r-out co"><span class="r-pr">#></span> 47: 93.7031 -6.4232 -0.0796 2.3006 -1.0028 6.1552 5.5756 0.5092 0.1243 0.1887 6.1716 1.7279</span> +<span class="r-out co"><span class="r-pr">#></span> 48: 93.5210 -6.2770 -0.0794 2.2948 -1.0122 5.8475 5.2968 0.5098 0.1247 0.1863 5.9847 1.7994</span> +<span class="r-out co"><span class="r-pr">#></span> 49: 93.3676 -6.4486 -0.0754 2.3079 -1.0061 5.5551 5.4356 0.5018 0.1198 0.1858 6.1108 1.7598</span> +<span class="r-out co"><span class="r-pr">#></span> 50: 93.8573 -6.3944 -0.0755 2.3057 -1.0038 5.2773 5.2487 0.5063 0.1193 0.1843 6.0935 1.7725</span> +<span class="r-out co"><span class="r-pr">#></span> 51: 93.7004 -6.2783 -0.0854 2.2836 -1.0074 5.0135 4.9863 0.4932 0.1269 0.1858 6.1630 1.8063</span> +<span class="r-out co"><span class="r-pr">#></span> 52: 93.4843 -6.3763 -0.0962 2.2731 -1.0073 4.7628 5.0969 0.4815 0.1345 0.1924 6.0823 1.8013</span> +<span class="r-out co"><span class="r-pr">#></span> 53: 93.6971 -6.5002 -0.0887 2.2774 -1.0111 4.5246 5.7428 0.4726 0.1346 0.1982 6.1744 1.7695</span> +<span class="r-out co"><span class="r-pr">#></span> 54: 93.6176 -6.4928 -0.0917 2.2648 -1.0220 4.2984 5.4557 0.4765 0.1419 0.2017 6.3732 1.8195</span> +<span class="r-out co"><span class="r-pr">#></span> 55: 93.7072 -6.5760 -0.0833 2.2865 -1.0282 4.0835 5.9775 0.4732 0.1434 0.1963 6.3653 1.7028</span> +<span class="r-out co"><span class="r-pr">#></span> 56: 94.1360 -6.6854 -0.0901 2.2941 -1.0244 3.8793 7.2562 0.4637 0.1393 0.1935 6.3001 1.7878</span> +<span class="r-out co"><span class="r-pr">#></span> 57: 93.4627 -6.6255 -0.1049 2.2502 -1.0233 3.6854 6.8934 0.4847 0.1323 0.1878 6.2357 1.8480</span> +<span class="r-out co"><span class="r-pr">#></span> 58: 93.8066 -6.6603 -0.1049 2.2362 -1.0280 3.5011 6.9334 0.4847 0.1397 0.1872 6.3582 1.7787</span> +<span class="r-out co"><span class="r-pr">#></span> 59: 93.8599 -6.7837 -0.1046 2.2450 -1.0274 3.3260 8.4672 0.4853 0.1332 0.1833 6.1248 1.8066</span> +<span class="r-out co"><span class="r-pr">#></span> 60: 93.6190 -6.5618 -0.1055 2.2381 -1.0244 3.1597 8.0438 0.4742 0.1390 0.1858 6.2589 1.7881</span> +<span class="r-out co"><span class="r-pr">#></span> 61: 93.7045 -6.6482 -0.1159 2.2413 -1.0272 3.2942 7.8485 0.4655 0.1406 0.1827 5.8425 1.7744</span> +<span class="r-out co"><span class="r-pr">#></span> 62: 93.5232 -6.5027 -0.1168 2.2418 -1.0187 3.3810 7.4560 0.4766 0.1414 0.1790 5.9349 1.7717</span> +<span class="r-out co"><span class="r-pr">#></span> 63: 93.4884 -6.4221 -0.1164 2.2505 -1.0062 3.2119 7.0832 0.4768 0.1422 0.1752 6.0193 1.7434</span> +<span class="r-out co"><span class="r-pr">#></span> 64: 93.2305 -6.4456 -0.1153 2.2573 -1.0062 4.1468 6.7291 0.4776 0.1395 0.1753 5.8355 1.7529</span> +<span class="r-out co"><span class="r-pr">#></span> 65: 93.3743 -6.3237 -0.1227 2.2484 -1.0102 3.9395 6.3926 0.4864 0.1374 0.1800 5.6731 1.7808</span> +<span class="r-out co"><span class="r-pr">#></span> 66: 93.7132 -6.3178 -0.1186 2.2389 -0.9894 4.0557 6.0730 0.4909 0.1426 0.1807 5.7099 1.7283</span> +<span class="r-out co"><span class="r-pr">#></span> 67: 93.7490 -6.3514 -0.1155 2.2445 -0.9946 3.8529 5.7693 0.4938 0.1379 0.1830 5.7366 1.7847</span> +<span class="r-out co"><span class="r-pr">#></span> 68: 93.7617 -6.1181 -0.1251 2.2487 -0.9841 3.7650 5.4809 0.4816 0.1549 0.1769 5.6569 1.7415</span> +<span class="r-out co"><span class="r-pr">#></span> 69: 93.4342 -6.3588 -0.1301 2.2350 -0.9813 4.5688 5.2068 0.4745 0.1624 0.1736 5.5771 1.7091</span> +<span class="r-out co"><span class="r-pr">#></span> 70: 93.5303 -6.3266 -0.1330 2.2384 -0.9753 4.3404 4.9465 0.4734 0.1563 0.1699 5.5332 1.7256</span> +<span class="r-out co"><span class="r-pr">#></span> 71: 93.4733 -6.2859 -0.1364 2.2170 -0.9781 4.1234 4.6992 0.4701 0.1604 0.1649 5.6661 1.7335</span> +<span class="r-out co"><span class="r-pr">#></span> 72: 93.3055 -6.2502 -0.1462 2.2156 -0.9724 3.9172 4.7693 0.4519 0.1607 0.1582 5.4776 1.7679</span> +<span class="r-out co"><span class="r-pr">#></span> 73: 93.3010 -6.6844 -0.1490 2.2262 -0.9777 3.7213 6.9975 0.4426 0.1848 0.1640 5.7066 1.7588</span> +<span class="r-out co"><span class="r-pr">#></span> 74: 93.1104 -6.6720 -0.1484 2.2079 -0.9982 3.5353 6.7811 0.4436 0.1807 0.1732 5.7700 1.7343</span> +<span class="r-out co"><span class="r-pr">#></span> 75: 93.4534 -6.9644 -0.1480 2.2078 -0.9930 3.3585 8.7027 0.4497 0.1717 0.1708 5.5371 1.7098</span> +<span class="r-out co"><span class="r-pr">#></span> 76: 93.5886 -6.3503 -0.1491 2.1958 -0.9884 3.7136 8.2676 0.4509 0.1731 0.1706 5.3943 1.7340</span> +<span class="r-out co"><span class="r-pr">#></span> 77: 93.4345 -6.4976 -0.1531 2.1831 -0.9928 4.5945 7.8542 0.4592 0.1741 0.1703 5.5564 1.7164</span> +<span class="r-out co"><span class="r-pr">#></span> 78: 93.6007 -6.4885 -0.1538 2.1850 -0.9919 4.3647 7.4615 0.4607 0.1803 0.1692 5.4698 1.7354</span> +<span class="r-out co"><span class="r-pr">#></span> 79: 93.2897 -7.0329 -0.1518 2.1935 -0.9863 4.6922 10.9870 0.4569 0.1790 0.1608 5.3799 1.7484</span> +<span class="r-out co"><span class="r-pr">#></span> 80: 93.4130 -6.6634 -0.1531 2.1865 -0.9839 5.4720 10.4377 0.4585 0.1852 0.1543 5.4298 1.7237</span> +<span class="r-out co"><span class="r-pr">#></span> 81: 93.5828 -6.7204 -0.1563 2.1914 -0.9882 5.1984 9.9158 0.4548 0.1973 0.1600 5.4425 1.7741</span> +<span class="r-out co"><span class="r-pr">#></span> 82: 93.4450 -6.7357 -0.1537 2.1964 -0.9958 4.9384 10.1331 0.4577 0.1874 0.1632 5.6874 1.7789</span> +<span class="r-out co"><span class="r-pr">#></span> 83: 93.6109 -6.9249 -0.1493 2.2061 -0.9945 4.6915 11.1537 0.4474 0.1781 0.1686 5.4249 1.7317</span> +<span class="r-out co"><span class="r-pr">#></span> 84: 93.7133 -6.8029 -0.1493 2.2016 -0.9886 4.4569 10.9568 0.4474 0.1715 0.1689 5.5426 1.7227</span> +<span class="r-out co"><span class="r-pr">#></span> 85: 93.8040 -6.6434 -0.1483 2.2032 -0.9861 5.4991 10.4090 0.4330 0.1749 0.1726 5.4570 1.7332</span> +<span class="r-out co"><span class="r-pr">#></span> 86: 93.9029 -6.7750 -0.1472 2.2066 -0.9892 5.2241 11.7325 0.4352 0.1819 0.1644 5.5652 1.6802</span> +<span class="r-out co"><span class="r-pr">#></span> 87: 93.8127 -6.7015 -0.1499 2.2019 -0.9891 4.9629 11.1459 0.4292 0.1977 0.1661 5.7122 1.6713</span> +<span class="r-out co"><span class="r-pr">#></span> 88: 93.6777 -6.7044 -0.1440 2.2074 -1.0050 4.7148 10.5886 0.4379 0.1878 0.1750 5.6084 1.7096</span> +<span class="r-out co"><span class="r-pr">#></span> 89: 94.0481 -6.2990 -0.1443 2.2085 -0.9869 4.4790 10.0591 0.4355 0.1951 0.1688 5.4280 1.8093</span> +<span class="r-out co"><span class="r-pr">#></span> 90: 93.6399 -6.3965 -0.1429 2.2138 -0.9737 5.1306 9.5562 0.4367 0.1917 0.1604 5.5652 1.7458</span> +<span class="r-out co"><span class="r-pr">#></span> 91: 93.8670 -6.3075 -0.1426 2.2128 -0.9856 5.1368 9.0784 0.4427 0.1993 0.1546 5.3927 1.8246</span> +<span class="r-out co"><span class="r-pr">#></span> 92: 93.7332 -6.4793 -0.1426 2.2091 -0.9835 5.0102 8.6245 0.4427 0.1986 0.1585 5.4463 1.7343</span> +<span class="r-out co"><span class="r-pr">#></span> 93: 93.8211 -6.3270 -0.1416 2.2123 -0.9941 4.7597 8.1932 0.4431 0.1908 0.1689 5.5213 1.7093</span> +<span class="r-out co"><span class="r-pr">#></span> 94: 93.7499 -6.0880 -0.1390 2.2158 -0.9960 5.1992 7.7836 0.4444 0.1958 0.1733 5.5329 1.7880</span> +<span class="r-out co"><span class="r-pr">#></span> 95: 93.6253 -6.2196 -0.1436 2.2126 -1.0053 4.9392 7.3944 0.4383 0.2011 0.1717 5.6042 1.7460</span> +<span class="r-out co"><span class="r-pr">#></span> 96: 93.8862 -6.1475 -0.1408 2.2211 -0.9922 4.6923 7.0247 0.4347 0.2077 0.1669 5.6807 1.6943</span> +<span class="r-out co"><span class="r-pr">#></span> 97: 93.7610 -6.2409 -0.1368 2.2281 -0.9864 4.4576 6.6734 0.4313 0.2084 0.1723 5.5387 1.7075</span> +<span class="r-out co"><span class="r-pr">#></span> 98: 93.5362 -6.3378 -0.1368 2.2294 -0.9813 4.2348 6.3398 0.4313 0.2127 0.1877 5.5850 1.6627</span> +<span class="r-out co"><span class="r-pr">#></span> 99: 93.5044 -6.2557 -0.1311 2.2282 -0.9993 4.0230 6.0228 0.4461 0.2167 0.1879 5.6437 1.7076</span> +<span class="r-out co"><span class="r-pr">#></span> 100: 93.3102 -6.3602 -0.1311 2.2368 -1.0040 3.8219 5.7216 0.4461 0.2139 0.1875 5.8029 1.7592</span> +<span class="r-out co"><span class="r-pr">#></span> 101: 93.4687 -6.0385 -0.1241 2.2347 -1.0031 3.6308 5.4356 0.4483 0.2035 0.1816 6.0097 1.7002</span> +<span class="r-out co"><span class="r-pr">#></span> 102: 93.6536 -6.2867 -0.1299 2.2421 -1.0002 3.4492 5.1743 0.4434 0.1993 0.1872 5.8540 1.7162</span> +<span class="r-out co"><span class="r-pr">#></span> 103: 93.9532 -6.2261 -0.1277 2.2361 -0.9931 3.2768 5.0546 0.4450 0.2069 0.1884 5.6688 1.7324</span> +<span class="r-out co"><span class="r-pr">#></span> 104: 93.9839 -6.1980 -0.1287 2.2286 -1.0081 3.1129 5.0671 0.4475 0.1997 0.1985 5.7690 1.7636</span> +<span class="r-out co"><span class="r-pr">#></span> 105: 94.1682 -6.1671 -0.1283 2.2217 -1.0154 2.9573 4.8137 0.4481 0.1976 0.1965 5.9277 1.7386</span> +<span class="r-out co"><span class="r-pr">#></span> 106: 94.2778 -6.1839 -0.1243 2.2323 -1.0022 3.5381 4.5730 0.4707 0.1980 0.1932 5.7059 1.7184</span> +<span class="r-out co"><span class="r-pr">#></span> 107: 94.3667 -5.9941 -0.1182 2.2283 -1.0191 3.3612 4.3444 0.4753 0.1984 0.1986 5.7813 1.7446</span> +<span class="r-out co"><span class="r-pr">#></span> 108: 94.2722 -6.1869 -0.1171 2.2293 -1.0027 3.6659 4.6329 0.4742 0.1986 0.2011 5.7827 1.7074</span> +<span class="r-out co"><span class="r-pr">#></span> 109: 94.1997 -6.2385 -0.1172 2.2241 -1.0083 3.4826 4.7954 0.4721 0.2027 0.2020 5.8339 1.7650</span> +<span class="r-out co"><span class="r-pr">#></span> 110: 94.3017 -6.3774 -0.1291 2.2229 -0.9857 3.7634 5.8516 0.4810 0.2126 0.1984 5.7961 1.6706</span> +<span class="r-out co"><span class="r-pr">#></span> 111: 93.9803 -6.0240 -0.1258 2.2273 -0.9879 3.5752 5.5590 0.4749 0.2060 0.1976 5.6243 1.7082</span> +<span class="r-out co"><span class="r-pr">#></span> 112: 94.1307 -6.0036 -0.1253 2.2365 -0.9886 4.0368 5.2810 0.4760 0.2060 0.1975 5.5732 1.7063</span> +<span class="r-out co"><span class="r-pr">#></span> 113: 93.8676 -6.2496 -0.1118 2.2600 -1.0080 3.8350 5.0170 0.4855 0.2109 0.2006 5.6406 1.7357</span> +<span class="r-out co"><span class="r-pr">#></span> 114: 93.5949 -6.3200 -0.1044 2.2449 -1.0172 3.6472 4.7661 0.4868 0.2095 0.2131 5.7690 1.7428</span> +<span class="r-out co"><span class="r-pr">#></span> 115: 93.6997 -6.3282 -0.1046 2.2567 -1.0135 3.4648 4.8622 0.4876 0.2264 0.2134 5.8853 1.7823</span> +<span class="r-out co"><span class="r-pr">#></span> 116: 93.8191 -6.0802 -0.1087 2.2535 -1.0011 3.4347 4.6191 0.4786 0.2176 0.2108 5.6553 1.7802</span> +<span class="r-out co"><span class="r-pr">#></span> 117: 93.8575 -6.0930 -0.1022 2.2498 -0.9898 3.3071 4.3881 0.4822 0.2163 0.2075 5.7806 1.8150</span> +<span class="r-out co"><span class="r-pr">#></span> 118: 93.9164 -5.9787 -0.1133 2.2535 -0.9861 4.2578 4.1687 0.4687 0.2198 0.2088 5.4441 1.8411</span> +<span class="r-out co"><span class="r-pr">#></span> 119: 93.8748 -6.0108 -0.1165 2.2488 -0.9775 4.0449 3.9603 0.4653 0.2271 0.2032 5.6119 1.7501</span> +<span class="r-out co"><span class="r-pr">#></span> 120: 93.6001 -6.0447 -0.1144 2.2477 -0.9821 3.8426 3.7623 0.4641 0.2223 0.2055 5.6454 1.7244</span> +<span class="r-out co"><span class="r-pr">#></span> 121: 93.6712 -5.9851 -0.1195 2.2484 -0.9917 3.6505 3.5742 0.4600 0.2143 0.2010 5.4083 1.7965</span> +<span class="r-out co"><span class="r-pr">#></span> 122: 93.6859 -6.0390 -0.1145 2.2497 -0.9888 3.4680 3.5595 0.4618 0.2136 0.1986 5.4111 1.7519</span> +<span class="r-out co"><span class="r-pr">#></span> 123: 93.6014 -5.8383 -0.1145 2.2584 -0.9893 3.6047 3.3815 0.4618 0.2155 0.2045 5.3624 1.7023</span> +<span class="r-out co"><span class="r-pr">#></span> 124: 93.6333 -5.7861 -0.1131 2.2556 -0.9872 3.4245 3.2125 0.4621 0.2153 0.2025 5.3930 1.7036</span> +<span class="r-out co"><span class="r-pr">#></span> 125: 93.4504 -5.9483 -0.1154 2.2531 -0.9924 3.2533 3.0518 0.4640 0.2175 0.2030 5.5097 1.6830</span> +<span class="r-out co"><span class="r-pr">#></span> 126: 93.5693 -5.8818 -0.1120 2.2506 -0.9960 3.0906 2.8992 0.4606 0.2267 0.2016 5.4583 1.6650</span> +<span class="r-out co"><span class="r-pr">#></span> 127: 93.7074 -5.8191 -0.1178 2.2412 -0.9891 2.9361 2.7543 0.4688 0.2234 0.2039 5.4861 1.8125</span> +<span class="r-out co"><span class="r-pr">#></span> 128: 93.5959 -5.8842 -0.1179 2.2544 -0.9985 3.0224 2.6166 0.4700 0.2237 0.2019 5.6417 1.8454</span> +<span class="r-out co"><span class="r-pr">#></span> 129: 93.5600 -5.8683 -0.1161 2.2365 -0.9987 3.4186 2.4857 0.4721 0.2182 0.1918 5.4391 1.8145</span> +<span class="r-out co"><span class="r-pr">#></span> 130: 93.4104 -5.8226 -0.1126 2.2355 -0.9892 3.3648 2.4231 0.4763 0.2212 0.1873 5.3999 1.7457</span> +<span class="r-out co"><span class="r-pr">#></span> 131: 93.5045 -5.7255 -0.1118 2.2486 -0.9918 4.1951 2.3020 0.4776 0.2121 0.1927 5.4342 1.7744</span> +<span class="r-out co"><span class="r-pr">#></span> 132: 93.2626 -5.8379 -0.1097 2.2510 -0.9933 3.9853 2.5572 0.4763 0.2114 0.1966 5.2979 1.7239</span> +<span class="r-out co"><span class="r-pr">#></span> 133: 93.4370 -5.9097 -0.1049 2.2578 -0.9939 4.2190 2.8246 0.4738 0.2036 0.2020 5.2853 1.6765</span> +<span class="r-out co"><span class="r-pr">#></span> 134: 93.8665 -5.9439 -0.1035 2.2654 -0.9832 4.0081 3.1228 0.4756 0.2102 0.1961 5.3467 1.7177</span> +<span class="r-out co"><span class="r-pr">#></span> 135: 93.6301 -5.8062 -0.1031 2.2702 -0.9737 3.9024 2.9667 0.4748 0.2101 0.2003 5.3053 1.6977</span> +<span class="r-out co"><span class="r-pr">#></span> 136: 93.7744 -5.9328 -0.1055 2.2685 -0.9764 3.7072 2.9952 0.4721 0.2096 0.1949 5.4319 1.6864</span> +<span class="r-out co"><span class="r-pr">#></span> 137: 93.6734 -5.9886 -0.1107 2.2517 -0.9732 3.8811 3.4962 0.4642 0.2204 0.1924 5.4294 1.6684</span> +<span class="r-out co"><span class="r-pr">#></span> 138: 93.7128 -5.9927 -0.1119 2.2517 -0.9775 3.6870 3.4543 0.4667 0.2204 0.1953 5.3912 1.7060</span> +<span class="r-out co"><span class="r-pr">#></span> 139: 93.6530 -6.1296 -0.1210 2.2456 -0.9929 3.5027 4.6472 0.4527 0.2296 0.1855 5.4953 1.7242</span> +<span class="r-out co"><span class="r-pr">#></span> 140: 93.9344 -6.2519 -0.1384 2.2304 -0.9970 3.6814 4.4707 0.4337 0.2182 0.1762 5.5643 1.7596</span> +<span class="r-out co"><span class="r-pr">#></span> 141: 93.7356 -6.2804 -0.1296 2.2549 -0.9921 3.9811 4.4876 0.4218 0.2361 0.1674 5.3531 1.7175</span> +<span class="r-out co"><span class="r-pr">#></span> 142: 93.7399 -6.0023 -0.1098 2.2611 -0.9815 3.7821 4.2632 0.4395 0.2421 0.1807 5.3139 1.7191</span> +<span class="r-out co"><span class="r-pr">#></span> 143: 93.4732 -6.0376 -0.1108 2.2689 -0.9734 3.5930 4.0500 0.4396 0.2541 0.1718 5.2930 1.6229</span> +<span class="r-out co"><span class="r-pr">#></span> 144: 93.4900 -5.9517 -0.1093 2.2876 -0.9675 3.4133 3.8475 0.4337 0.2542 0.1711 5.4258 1.5660</span> +<span class="r-out co"><span class="r-pr">#></span> 145: 93.4090 -5.9596 -0.1000 2.2942 -0.9756 3.2426 3.6551 0.4274 0.2422 0.1671 5.3539 1.6971</span> +<span class="r-out co"><span class="r-pr">#></span> 146: 93.4142 -5.9549 -0.0982 2.2846 -0.9704 3.0805 3.6092 0.4226 0.2339 0.1745 5.5092 1.6696</span> +<span class="r-out co"><span class="r-pr">#></span> 147: 93.4409 -6.0720 -0.0971 2.2942 -0.9891 2.9265 3.9922 0.4224 0.2373 0.1781 5.5599 1.6080</span> +<span class="r-out co"><span class="r-pr">#></span> 148: 93.4504 -6.2201 -0.0980 2.2855 -0.9832 2.7802 4.6985 0.4104 0.2464 0.1856 5.5016 1.5877</span> +<span class="r-out co"><span class="r-pr">#></span> 149: 93.4240 -6.2122 -0.1005 2.2728 -0.9881 3.7659 4.7755 0.4082 0.2642 0.1885 5.4942 1.5534</span> +<span class="r-out co"><span class="r-pr">#></span> 150: 93.5094 -6.1295 -0.1087 2.2717 -0.9941 3.5776 4.5367 0.4109 0.2611 0.1928 5.3468 1.5585</span> +<span class="r-out co"><span class="r-pr">#></span> 151: 93.4038 -6.2751 -0.1130 2.2643 -0.9892 3.3987 4.9866 0.4172 0.2638 0.1905 5.4955 1.6256</span> +<span class="r-out co"><span class="r-pr">#></span> 152: 93.5072 -6.3361 -0.1147 2.2627 -0.9988 2.3580 5.3824 0.4175 0.2656 0.1819 5.7685 1.6126</span> +<span class="r-out co"><span class="r-pr">#></span> 153: 93.3582 -6.2019 -0.1227 2.2526 -0.9929 2.5874 4.7052 0.4348 0.2621 0.1810 5.5149 1.6181</span> +<span class="r-out co"><span class="r-pr">#></span> 154: 93.1890 -6.3537 -0.1263 2.2446 -0.9871 2.4073 5.7070 0.4351 0.2586 0.1829 5.3136 1.6272</span> +<span class="r-out co"><span class="r-pr">#></span> 155: 93.1706 -6.4117 -0.1260 2.2484 -0.9845 2.3035 6.0004 0.4463 0.2586 0.1781 5.4260 1.6494</span> +<span class="r-out co"><span class="r-pr">#></span> 156: 93.3240 -6.3931 -0.1259 2.2469 -0.9824 2.5659 5.7375 0.4466 0.2781 0.1754 5.6202 1.6591</span> +<span class="r-out co"><span class="r-pr">#></span> 157: 93.3239 -6.1812 -0.1242 2.2541 -0.9743 1.6054 4.5906 0.4478 0.2657 0.1758 5.6806 1.6367</span> +<span class="r-out co"><span class="r-pr">#></span> 158: 93.3756 -6.2562 -0.1264 2.2706 -0.9888 1.5329 4.6790 0.4458 0.2532 0.1728 5.7756 1.6248</span> +<span class="r-out co"><span class="r-pr">#></span> 159: 93.3034 -6.3291 -0.1217 2.2524 -0.9954 1.7774 5.7204 0.4532 0.2642 0.1715 5.8189 1.6830</span> +<span class="r-out co"><span class="r-pr">#></span> 160: 93.4387 -6.5115 -0.1196 2.2488 -0.9846 2.2219 6.4960 0.4555 0.2728 0.1689 5.5273 1.6332</span> +<span class="r-out co"><span class="r-pr">#></span> 161: 93.7646 -6.3820 -0.1231 2.2520 -0.9837 2.8322 5.7269 0.4498 0.2712 0.1730 5.3659 1.5787</span> +<span class="r-out co"><span class="r-pr">#></span> 162: 93.6252 -6.4563 -0.1243 2.2472 -0.9867 2.8322 5.9119 0.4502 0.2671 0.1726 5.4519 1.5819</span> +<span class="r-out co"><span class="r-pr">#></span> 163: 93.6787 -6.6444 -0.1292 2.2366 -0.9899 2.0520 7.4835 0.4556 0.2705 0.1689 5.4095 1.5883</span> +<span class="r-out co"><span class="r-pr">#></span> 164: 93.7458 -6.9330 -0.1257 2.2430 -0.9872 1.7825 9.4340 0.4495 0.2701 0.1593 5.4517 1.6116</span> +<span class="r-out co"><span class="r-pr">#></span> 165: 93.7370 -6.9118 -0.1250 2.2421 -0.9832 1.9949 10.6549 0.4499 0.2685 0.1622 5.6272 1.6075</span> +<span class="r-out co"><span class="r-pr">#></span> 166: 94.0889 -6.8704 -0.1276 2.2409 -0.9872 1.5618 10.4435 0.4482 0.2608 0.1648 5.5891 1.6208</span> +<span class="r-out co"><span class="r-pr">#></span> 167: 94.1319 -7.2779 -0.1206 2.2505 -0.9894 1.5063 13.4312 0.4393 0.2549 0.1661 5.6013 1.6043</span> +<span class="r-out co"><span class="r-pr">#></span> 168: 93.8341 -6.9310 -0.1140 2.2495 -0.9844 1.7329 11.3224 0.4463 0.2540 0.1629 5.8366 1.6765</span> +<span class="r-out co"><span class="r-pr">#></span> 169: 93.8923 -6.6547 -0.1173 2.2620 -0.9872 1.4531 8.4608 0.4419 0.2414 0.1666 5.8784 1.6268</span> +<span class="r-out co"><span class="r-pr">#></span> 170: 94.0072 -6.3970 -0.1173 2.2606 -0.9861 1.4164 6.9237 0.4419 0.2468 0.1656 5.8793 1.6387</span> +<span class="r-out co"><span class="r-pr">#></span> 171: 93.8690 -6.5151 -0.1079 2.2482 -0.9880 1.9225 7.7681 0.4547 0.2404 0.1523 6.0158 1.6281</span> +<span class="r-out co"><span class="r-pr">#></span> 172: 93.6847 -6.3416 -0.1095 2.2438 -0.9849 2.0143 5.5739 0.4498 0.2450 0.1534 6.1355 1.6422</span> +<span class="r-out co"><span class="r-pr">#></span> 173: 93.4817 -6.3165 -0.1115 2.2573 -0.9885 1.6855 5.5626 0.4440 0.2471 0.1542 6.1343 1.6337</span> +<span class="r-out co"><span class="r-pr">#></span> 174: 93.6781 -6.2722 -0.1113 2.2521 -0.9958 1.9186 5.3383 0.4471 0.2427 0.1565 6.1081 1.6358</span> +<span class="r-out co"><span class="r-pr">#></span> 175: 93.7764 -6.1664 -0.1113 2.2468 -0.9864 1.6286 4.6233 0.4471 0.2426 0.1596 5.8892 1.6375</span> +<span class="r-out co"><span class="r-pr">#></span> 176: 93.9246 -6.2164 -0.1160 2.2529 -0.9853 1.0357 4.8013 0.4422 0.2471 0.1756 5.7340 1.6016</span> +<span class="r-out co"><span class="r-pr">#></span> 177: 93.9711 -6.1274 -0.1112 2.2540 -0.9883 1.2079 4.1536 0.4415 0.2492 0.1783 5.8399 1.6291</span> +<span class="r-out co"><span class="r-pr">#></span> 178: 93.9212 -6.0532 -0.1116 2.2593 -0.9742 1.2409 3.6443 0.4489 0.2458 0.1683 5.8422 1.6290</span> +<span class="r-out co"><span class="r-pr">#></span> 179: 94.0137 -6.0739 -0.1095 2.2664 -0.9778 1.5060 3.9878 0.4506 0.2370 0.1746 6.0349 1.6326</span> +<span class="r-out co"><span class="r-pr">#></span> 180: 93.9247 -6.0681 -0.1130 2.2660 -0.9934 1.9619 3.9582 0.4474 0.2328 0.1773 5.8082 1.6740</span> +<span class="r-out co"><span class="r-pr">#></span> 181: 93.7150 -6.0191 -0.1153 2.2558 -0.9915 2.6849 3.7075 0.4491 0.2283 0.1759 5.7187 1.6842</span> +<span class="r-out co"><span class="r-pr">#></span> 182: 93.5908 -6.1098 -0.1111 2.2769 -0.9942 3.0096 3.9325 0.4643 0.2275 0.1736 5.9243 1.6466</span> +<span class="r-out co"><span class="r-pr">#></span> 183: 93.3386 -6.0987 -0.1131 2.2630 -0.9962 3.5457 4.1285 0.4693 0.2373 0.1751 5.6948 1.7222</span> +<span class="r-out co"><span class="r-pr">#></span> 184: 93.4889 -6.3097 -0.1134 2.2660 -0.9720 3.0855 5.2642 0.4648 0.2255 0.1585 5.6827 1.7444</span> +<span class="r-out co"><span class="r-pr">#></span> 185: 93.6387 -6.1883 -0.1188 2.2622 -0.9603 3.3568 4.8291 0.4554 0.2223 0.1681 5.7089 1.8164</span> +<span class="r-out co"><span class="r-pr">#></span> 186: 93.3420 -6.2909 -0.1195 2.2656 -0.9835 3.2124 4.8317 0.4541 0.2286 0.1531 5.7574 1.7708</span> +<span class="r-out co"><span class="r-pr">#></span> 187: 93.4395 -6.0358 -0.1165 2.2528 -0.9917 3.8299 3.3301 0.4518 0.2370 0.1593 5.8508 1.6988</span> +<span class="r-out co"><span class="r-pr">#></span> 188: 93.5358 -6.0105 -0.1161 2.2540 -0.9813 5.1249 3.3448 0.4522 0.2361 0.1660 5.8700 1.6525</span> +<span class="r-out co"><span class="r-pr">#></span> 189: 93.4932 -6.1199 -0.1129 2.2636 -0.9812 4.5430 4.3213 0.4428 0.2359 0.1907 5.6970 1.7268</span> +<span class="r-out co"><span class="r-pr">#></span> 190: 93.4754 -5.9088 -0.1171 2.2564 -0.9614 4.6253 3.2590 0.4410 0.2399 0.1864 5.7116 1.8140</span> +<span class="r-out co"><span class="r-pr">#></span> 191: 93.4709 -5.9676 -0.1171 2.2568 -0.9748 4.8326 3.6704 0.4410 0.2428 0.1812 5.5925 1.7267</span> +<span class="r-out co"><span class="r-pr">#></span> 192: 93.3895 -5.9940 -0.1191 2.2523 -0.9691 4.3019 3.5174 0.4360 0.2484 0.1591 5.4631 1.7057</span> +<span class="r-out co"><span class="r-pr">#></span> 193: 93.4904 -6.0400 -0.1173 2.2519 -0.9697 4.6476 3.6255 0.4389 0.2388 0.1694 5.5362 1.7174</span> +<span class="r-out co"><span class="r-pr">#></span> 194: 93.4591 -5.9642 -0.1245 2.2626 -0.9559 5.3125 3.8133 0.4297 0.2550 0.1660 5.7591 1.7344</span> +<span class="r-out co"><span class="r-pr">#></span> 195: 93.6610 -6.2211 -0.1226 2.2580 -0.9669 5.2051 4.9271 0.4318 0.2414 0.1811 5.7010 1.7710</span> +<span class="r-out co"><span class="r-pr">#></span> 196: 93.4249 -5.9570 -0.1068 2.2735 -0.9727 5.1049 3.4872 0.4442 0.2429 0.1815 5.7753 1.7379</span> +<span class="r-out co"><span class="r-pr">#></span> 197: 93.4082 -6.0568 -0.1054 2.2754 -0.9865 5.2827 3.9305 0.4554 0.2408 0.1925 5.7514 1.7163</span> +<span class="r-out co"><span class="r-pr">#></span> 198: 93.3856 -5.8616 -0.1087 2.2708 -0.9686 4.1369 3.0197 0.4530 0.2473 0.1878 5.6920 1.7043</span> +<span class="r-out co"><span class="r-pr">#></span> 199: 93.5488 -6.0494 -0.1167 2.2682 -0.9719 3.8010 3.8897 0.4600 0.2445 0.1860 5.7126 1.6605</span> +<span class="r-out co"><span class="r-pr">#></span> 200: 93.3779 -5.9779 -0.1110 2.2761 -0.9780 3.5955 3.4721 0.4595 0.2468 0.1941 5.7539 1.6736</span> +<span class="r-out co"><span class="r-pr">#></span> 201: 93.4946 -6.0259 -0.1102 2.2676 -0.9755 3.0583 3.7305 0.4592 0.2554 0.1921 5.8877 1.6730</span> +<span class="r-out co"><span class="r-pr">#></span> 202: 93.4698 -6.0522 -0.1110 2.2685 -0.9703 2.9421 3.8718 0.4579 0.2595 0.1906 5.8527 1.6701</span> +<span class="r-out co"><span class="r-pr">#></span> 203: 93.4625 -6.0744 -0.1132 2.2642 -0.9696 3.1854 4.0983 0.4589 0.2596 0.1886 5.7532 1.6655</span> +<span class="r-out co"><span class="r-pr">#></span> 204: 93.4984 -6.0853 -0.1138 2.2589 -0.9718 3.2826 4.1667 0.4581 0.2588 0.1851 5.7274 1.6694</span> +<span class="r-out co"><span class="r-pr">#></span> 205: 93.5279 -6.1054 -0.1151 2.2562 -0.9742 3.3257 4.2680 0.4569 0.2584 0.1832 5.6976 1.6777</span> +<span class="r-out co"><span class="r-pr">#></span> 206: 93.6025 -6.1087 -0.1174 2.2518 -0.9767 3.2399 4.2443 0.4582 0.2589 0.1822 5.6809 1.6775</span> +<span class="r-out co"><span class="r-pr">#></span> 207: 93.6382 -6.0990 -0.1204 2.2481 -0.9801 3.2768 4.1473 0.4579 0.2591 0.1823 5.6460 1.6819</span> +<span class="r-out co"><span class="r-pr">#></span> 208: 93.6250 -6.0878 -0.1224 2.2438 -0.9812 3.1815 4.0872 0.4579 0.2577 0.1818 5.6256 1.6887</span> +<span class="r-out co"><span class="r-pr">#></span> 209: 93.6102 -6.0740 -0.1255 2.2394 -0.9803 3.1716 3.9968 0.4561 0.2573 0.1812 5.6063 1.6886</span> +<span class="r-out co"><span class="r-pr">#></span> 210: 93.6005 -6.0571 -0.1277 2.2348 -0.9799 3.2408 3.8923 0.4548 0.2572 0.1798 5.5849 1.6912</span> +<span class="r-out co"><span class="r-pr">#></span> 211: 93.6270 -6.0425 -0.1306 2.2292 -0.9807 3.3500 3.8267 0.4538 0.2586 0.1792 5.5578 1.6992</span> +<span class="r-out co"><span class="r-pr">#></span> 212: 93.6641 -6.0403 -0.1331 2.2253 -0.9806 3.4487 3.8366 0.4529 0.2596 0.1786 5.5422 1.7022</span> +<span class="r-out co"><span class="r-pr">#></span> 213: 93.6743 -6.0344 -0.1354 2.2214 -0.9800 3.5484 3.8260 0.4518 0.2606 0.1781 5.5250 1.7069</span> +<span class="r-out co"><span class="r-pr">#></span> 214: 93.6719 -6.0405 -0.1377 2.2179 -0.9804 3.5538 3.8785 0.4506 0.2612 0.1769 5.5148 1.7087</span> +<span class="r-out co"><span class="r-pr">#></span> 215: 93.6743 -6.0403 -0.1396 2.2146 -0.9801 3.5578 3.9180 0.4496 0.2615 0.1761 5.5118 1.7094</span> +<span class="r-out co"><span class="r-pr">#></span> 216: 93.6666 -6.0436 -0.1413 2.2115 -0.9796 3.5848 3.9484 0.4488 0.2624 0.1755 5.5015 1.7116</span> +<span class="r-out co"><span class="r-pr">#></span> 217: 93.6715 -6.0438 -0.1430 2.2086 -0.9794 3.6188 3.9603 0.4478 0.2631 0.1748 5.4884 1.7132</span> +<span class="r-out co"><span class="r-pr">#></span> 218: 93.6765 -6.0488 -0.1441 2.2060 -0.9796 3.6126 3.9885 0.4471 0.2632 0.1746 5.4714 1.7156</span> +<span class="r-out co"><span class="r-pr">#></span> 219: 93.6714 -6.0557 -0.1453 2.2038 -0.9798 3.6603 4.0118 0.4463 0.2632 0.1735 5.4593 1.7235</span> +<span class="r-out co"><span class="r-pr">#></span> 220: 93.6728 -6.0711 -0.1462 2.2027 -0.9794 3.7244 4.0910 0.4457 0.2639 0.1730 5.4531 1.7241</span> +<span class="r-out co"><span class="r-pr">#></span> 221: 93.6723 -6.0822 -0.1470 2.2015 -0.9788 3.7754 4.1554 0.4450 0.2647 0.1724 5.4511 1.7247</span> +<span class="r-out co"><span class="r-pr">#></span> 222: 93.6789 -6.0745 -0.1480 2.1998 -0.9780 3.8735 4.1186 0.4442 0.2662 0.1718 5.4419 1.7258</span> +<span class="r-out co"><span class="r-pr">#></span> 223: 93.6891 -6.0700 -0.1488 2.1984 -0.9778 3.9353 4.0998 0.4434 0.2681 0.1715 5.4375 1.7251</span> +<span class="r-out co"><span class="r-pr">#></span> 224: 93.7125 -6.0705 -0.1496 2.1976 -0.9774 4.0220 4.0861 0.4427 0.2697 0.1711 5.4378 1.7230</span> +<span class="r-out co"><span class="r-pr">#></span> 225: 93.7332 -6.0695 -0.1502 2.1966 -0.9775 4.0553 4.0669 0.4422 0.2712 0.1711 5.4355 1.7205</span> +<span class="r-out co"><span class="r-pr">#></span> 226: 93.7631 -6.0712 -0.1508 2.1951 -0.9779 4.0755 4.0572 0.4417 0.2728 0.1712 5.4347 1.7190</span> +<span class="r-out co"><span class="r-pr">#></span> 227: 93.7912 -6.0687 -0.1512 2.1938 -0.9785 4.0621 4.0439 0.4409 0.2742 0.1716 5.4325 1.7189</span> +<span class="r-out co"><span class="r-pr">#></span> 228: 93.8077 -6.0644 -0.1517 2.1927 -0.9791 4.0246 4.0190 0.4400 0.2755 0.1722 5.4269 1.7193</span> +<span class="r-out co"><span class="r-pr">#></span> 229: 93.8255 -6.0661 -0.1521 2.1909 -0.9796 3.9958 4.0166 0.4392 0.2769 0.1725 5.4214 1.7214</span> +<span class="r-out co"><span class="r-pr">#></span> 230: 93.8403 -6.0766 -0.1530 2.1895 -0.9802 4.0152 4.0548 0.4380 0.2788 0.1730 5.4214 1.7232</span> +<span class="r-out co"><span class="r-pr">#></span> 231: 93.8549 -6.0768 -0.1541 2.1877 -0.9810 4.0690 4.0542 0.4368 0.2803 0.1734 5.4157 1.7236</span> +<span class="r-out co"><span class="r-pr">#></span> 232: 93.8666 -6.0728 -0.1550 2.1858 -0.9816 4.0852 4.0337 0.4356 0.2818 0.1736 5.4136 1.7224</span> +<span class="r-out co"><span class="r-pr">#></span> 233: 93.8728 -6.0672 -0.1557 2.1844 -0.9820 4.1001 4.0000 0.4346 0.2828 0.1738 5.4028 1.7243</span> +<span class="r-out co"><span class="r-pr">#></span> 234: 93.8862 -6.0646 -0.1563 2.1830 -0.9825 4.1303 3.9850 0.4337 0.2838 0.1737 5.3924 1.7222</span> +<span class="r-out co"><span class="r-pr">#></span> 235: 93.8862 -6.0632 -0.1570 2.1819 -0.9827 4.1149 3.9735 0.4329 0.2847 0.1737 5.3846 1.7225</span> +<span class="r-out co"><span class="r-pr">#></span> 236: 93.8827 -6.0639 -0.1577 2.1814 -0.9834 4.1004 3.9711 0.4322 0.2852 0.1739 5.3838 1.7220</span> +<span class="r-out co"><span class="r-pr">#></span> 237: 93.8729 -6.0680 -0.1582 2.1808 -0.9840 4.0606 3.9866 0.4316 0.2857 0.1741 5.3806 1.7213</span> +<span class="r-out co"><span class="r-pr">#></span> 238: 93.8739 -6.0733 -0.1587 2.1806 -0.9845 4.0331 4.0011 0.4311 0.2859 0.1742 5.3775 1.7199</span> +<span class="r-out co"><span class="r-pr">#></span> 239: 93.8732 -6.0729 -0.1591 2.1802 -0.9853 3.9850 3.9892 0.4307 0.2859 0.1744 5.3782 1.7216</span> +<span class="r-out co"><span class="r-pr">#></span> 240: 93.8760 -6.0754 -0.1595 2.1796 -0.9854 3.9349 3.9867 0.4303 0.2858 0.1747 5.3781 1.7232</span> +<span class="r-out co"><span class="r-pr">#></span> 241: 93.8779 -6.0749 -0.1599 2.1791 -0.9853 3.9241 3.9801 0.4299 0.2858 0.1748 5.3757 1.7228</span> +<span class="r-out co"><span class="r-pr">#></span> 242: 93.8842 -6.0716 -0.1602 2.1786 -0.9852 3.9394 3.9651 0.4297 0.2859 0.1749 5.3726 1.7224</span> +<span class="r-out co"><span class="r-pr">#></span> 243: 93.8884 -6.0719 -0.1606 2.1778 -0.9851 3.9310 3.9741 0.4295 0.2857 0.1750 5.3705 1.7224</span> +<span class="r-out co"><span class="r-pr">#></span> 244: 93.8910 -6.0712 -0.1610 2.1771 -0.9850 3.9173 3.9819 0.4294 0.2856 0.1749 5.3700 1.7222</span> +<span class="r-out co"><span class="r-pr">#></span> 245: 93.9054 -6.0736 -0.1614 2.1764 -0.9854 3.9106 3.9984 0.4293 0.2856 0.1748 5.3711 1.7217</span> +<span class="r-out co"><span class="r-pr">#></span> 246: 93.9209 -6.0753 -0.1617 2.1757 -0.9859 3.9080 4.0071 0.4291 0.2852 0.1746 5.3711 1.7215</span> +<span class="r-out co"><span class="r-pr">#></span> 247: 93.9273 -6.0846 -0.1621 2.1752 -0.9861 3.8790 4.0580 0.4286 0.2851 0.1745 5.3755 1.7206</span> +<span class="r-out co"><span class="r-pr">#></span> 248: 93.9265 -6.0884 -0.1625 2.1749 -0.9865 3.8613 4.0784 0.4286 0.2848 0.1744 5.3760 1.7198</span> +<span class="r-out co"><span class="r-pr">#></span> 249: 93.9286 -6.0926 -0.1627 2.1746 -0.9872 3.8663 4.1008 0.4287 0.2845 0.1745 5.3755 1.7195</span> +<span class="r-out co"><span class="r-pr">#></span> 250: 93.9287 -6.0968 -0.1629 2.1744 -0.9878 3.8822 4.1269 0.4289 0.2844 0.1743 5.3755 1.7201</span> +<span class="r-out co"><span class="r-pr">#></span> 251: 93.9314 -6.1017 -0.1630 2.1739 -0.9882 3.8878 4.1495 0.4291 0.2843 0.1744 5.3729 1.7200</span> +<span class="r-out co"><span class="r-pr">#></span> 252: 93.9351 -6.1036 -0.1632 2.1734 -0.9885 3.8908 4.1545 0.4293 0.2843 0.1746 5.3684 1.7191</span> +<span class="r-out co"><span class="r-pr">#></span> 253: 93.9415 -6.1053 -0.1634 2.1729 -0.9889 3.8727 4.1602 0.4294 0.2842 0.1747 5.3650 1.7196</span> +<span class="r-out co"><span class="r-pr">#></span> 254: 93.9473 -6.1088 -0.1636 2.1723 -0.9891 3.8657 4.1769 0.4296 0.2843 0.1749 5.3666 1.7190</span> +<span class="r-out co"><span class="r-pr">#></span> 255: 93.9505 -6.1087 -0.1639 2.1717 -0.9888 3.8457 4.1720 0.4298 0.2841 0.1749 5.3617 1.7191</span> +<span class="r-out co"><span class="r-pr">#></span> 256: 93.9497 -6.1054 -0.1642 2.1715 -0.9885 3.8395 4.1559 0.4299 0.2839 0.1749 5.3598 1.7192</span> +<span class="r-out co"><span class="r-pr">#></span> 257: 93.9477 -6.1008 -0.1643 2.1713 -0.9882 3.8383 4.1360 0.4299 0.2836 0.1749 5.3567 1.7196</span> +<span class="r-out co"><span class="r-pr">#></span> 258: 93.9402 -6.0998 -0.1645 2.1713 -0.9880 3.8516 4.1288 0.4300 0.2832 0.1749 5.3565 1.7190</span> +<span class="r-out co"><span class="r-pr">#></span> 259: 93.9318 -6.0979 -0.1646 2.1711 -0.9879 3.8396 4.1182 0.4301 0.2829 0.1750 5.3583 1.7188</span> +<span class="r-out co"><span class="r-pr">#></span> 260: 93.9277 -6.1002 -0.1646 2.1713 -0.9879 3.8173 4.1273 0.4304 0.2826 0.1751 5.3611 1.7186</span> +<span class="r-out co"><span class="r-pr">#></span> 261: 93.9251 -6.0973 -0.1646 2.1714 -0.9879 3.8140 4.1105 0.4306 0.2822 0.1750 5.3588 1.7192</span> +<span class="r-out co"><span class="r-pr">#></span> 262: 93.9186 -6.1009 -0.1647 2.1715 -0.9880 3.8177 4.1303 0.4308 0.2822 0.1750 5.3604 1.7194</span> +<span class="r-out co"><span class="r-pr">#></span> 263: 93.9130 -6.1033 -0.1646 2.1715 -0.9880 3.8029 4.1529 0.4309 0.2822 0.1748 5.3647 1.7188</span> +<span class="r-out co"><span class="r-pr">#></span> 264: 93.9040 -6.1077 -0.1645 2.1717 -0.9879 3.7950 4.1820 0.4310 0.2822 0.1747 5.3699 1.7184</span> +<span class="r-out co"><span class="r-pr">#></span> 265: 93.9012 -6.1071 -0.1645 2.1714 -0.9879 3.7834 4.1895 0.4310 0.2822 0.1746 5.3755 1.7191</span> +<span class="r-out co"><span class="r-pr">#></span> 266: 93.8988 -6.1051 -0.1644 2.1714 -0.9879 3.7788 4.1822 0.4311 0.2822 0.1745 5.3765 1.7203</span> +<span class="r-out co"><span class="r-pr">#></span> 267: 93.8964 -6.1059 -0.1643 2.1714 -0.9877 3.7774 4.1896 0.4311 0.2822 0.1744 5.3792 1.7197</span> +<span class="r-out co"><span class="r-pr">#></span> 268: 93.8901 -6.1092 -0.1643 2.1715 -0.9876 3.7790 4.2198 0.4310 0.2822 0.1742 5.3811 1.7200</span> +<span class="r-out co"><span class="r-pr">#></span> 269: 93.8842 -6.1105 -0.1643 2.1717 -0.9875 3.7620 4.2336 0.4310 0.2823 0.1742 5.3838 1.7193</span> +<span class="r-out co"><span class="r-pr">#></span> 270: 93.8760 -6.1125 -0.1643 2.1721 -0.9874 3.7668 4.2483 0.4308 0.2823 0.1741 5.3852 1.7181</span> +<span class="r-out co"><span class="r-pr">#></span> 271: 93.8705 -6.1149 -0.1643 2.1722 -0.9873 3.7785 4.2625 0.4306 0.2823 0.1742 5.3853 1.7172</span> +<span class="r-out co"><span class="r-pr">#></span> 272: 93.8674 -6.1149 -0.1643 2.1723 -0.9871 3.7829 4.2581 0.4304 0.2823 0.1743 5.3836 1.7162</span> +<span class="r-out co"><span class="r-pr">#></span> 273: 93.8644 -6.1159 -0.1642 2.1725 -0.9870 3.7910 4.2631 0.4303 0.2825 0.1743 5.3818 1.7154</span> +<span class="r-out co"><span class="r-pr">#></span> 274: 93.8585 -6.1158 -0.1640 2.1728 -0.9869 3.7926 4.2612 0.4302 0.2825 0.1743 5.3816 1.7147</span> +<span class="r-out co"><span class="r-pr">#></span> 275: 93.8564 -6.1151 -0.1639 2.1732 -0.9867 3.8053 4.2581 0.4301 0.2826 0.1743 5.3804 1.7143</span> +<span class="r-out co"><span class="r-pr">#></span> 276: 93.8564 -6.1132 -0.1638 2.1736 -0.9866 3.7958 4.2486 0.4300 0.2827 0.1745 5.3810 1.7144</span> +<span class="r-out co"><span class="r-pr">#></span> 277: 93.8564 -6.1120 -0.1637 2.1741 -0.9867 3.7952 4.2426 0.4298 0.2829 0.1747 5.3808 1.7148</span> +<span class="r-out co"><span class="r-pr">#></span> 278: 93.8528 -6.1113 -0.1636 2.1743 -0.9867 3.7922 4.2352 0.4297 0.2832 0.1750 5.3819 1.7144</span> +<span class="r-out co"><span class="r-pr">#></span> 279: 93.8503 -6.1124 -0.1636 2.1744 -0.9867 3.7930 4.2390 0.4298 0.2834 0.1753 5.3826 1.7144</span> +<span class="r-out co"><span class="r-pr">#></span> 280: 93.8466 -6.1146 -0.1636 2.1743 -0.9867 3.7946 4.2470 0.4299 0.2838 0.1755 5.3832 1.7142</span> +<span class="r-out co"><span class="r-pr">#></span> 281: 93.8435 -6.1165 -0.1638 2.1743 -0.9867 3.7994 4.2552 0.4298 0.2840 0.1756 5.3828 1.7140</span> +<span class="r-out co"><span class="r-pr">#></span> 282: 93.8421 -6.1162 -0.1639 2.1741 -0.9868 3.7967 4.2496 0.4296 0.2843 0.1758 5.3816 1.7137</span> +<span class="r-out co"><span class="r-pr">#></span> 283: 93.8382 -6.1146 -0.1641 2.1740 -0.9866 3.7957 4.2387 0.4294 0.2845 0.1760 5.3796 1.7135</span> +<span class="r-out co"><span class="r-pr">#></span> 284: 93.8356 -6.1131 -0.1641 2.1740 -0.9865 3.7904 4.2263 0.4292 0.2848 0.1762 5.3776 1.7127</span> +<span class="r-out co"><span class="r-pr">#></span> 285: 93.8349 -6.1113 -0.1642 2.1740 -0.9865 3.7841 4.2129 0.4291 0.2850 0.1765 5.3763 1.7130</span> +<span class="r-out co"><span class="r-pr">#></span> 286: 93.8372 -6.1095 -0.1643 2.1741 -0.9864 3.7801 4.2035 0.4289 0.2853 0.1769 5.3779 1.7130</span> +<span class="r-out co"><span class="r-pr">#></span> 287: 93.8393 -6.1077 -0.1643 2.1741 -0.9864 3.7804 4.1908 0.4287 0.2857 0.1771 5.3785 1.7132</span> +<span class="r-out co"><span class="r-pr">#></span> 288: 93.8395 -6.1071 -0.1644 2.1740 -0.9866 3.7714 4.1834 0.4284 0.2859 0.1772 5.3798 1.7120</span> +<span class="r-out co"><span class="r-pr">#></span> 289: 93.8398 -6.1065 -0.1645 2.1738 -0.9865 3.7635 4.1765 0.4282 0.2861 0.1774 5.3821 1.7111</span> +<span class="r-out co"><span class="r-pr">#></span> 290: 93.8376 -6.1089 -0.1647 2.1737 -0.9865 3.7495 4.1853 0.4281 0.2863 0.1776 5.3852 1.7106</span> +<span class="r-out co"><span class="r-pr">#></span> 291: 93.8341 -6.1091 -0.1647 2.1738 -0.9863 3.7340 4.1854 0.4278 0.2865 0.1776 5.3868 1.7098</span> +<span class="r-out co"><span class="r-pr">#></span> 292: 93.8329 -6.1080 -0.1647 2.1741 -0.9863 3.7189 4.1760 0.4275 0.2868 0.1777 5.3885 1.7091</span> +<span class="r-out co"><span class="r-pr">#></span> 293: 93.8312 -6.1065 -0.1647 2.1743 -0.9862 3.7091 4.1651 0.4272 0.2871 0.1778 5.3896 1.7086</span> +<span class="r-out co"><span class="r-pr">#></span> 294: 93.8310 -6.1042 -0.1647 2.1745 -0.9861 3.6946 4.1521 0.4269 0.2874 0.1780 5.3908 1.7077</span> +<span class="r-out co"><span class="r-pr">#></span> 295: 93.8299 -6.1033 -0.1648 2.1747 -0.9861 3.6968 4.1433 0.4265 0.2880 0.1781 5.3904 1.7066</span> +<span class="r-out co"><span class="r-pr">#></span> 296: 93.8276 -6.1027 -0.1648 2.1749 -0.9862 3.7072 4.1361 0.4261 0.2885 0.1782 5.3910 1.7056</span> +<span class="r-out co"><span class="r-pr">#></span> 297: 93.8212 -6.1015 -0.1647 2.1750 -0.9859 3.7253 4.1278 0.4256 0.2891 0.1783 5.3927 1.7051</span> +<span class="r-out co"><span class="r-pr">#></span> 298: 93.8173 -6.0980 -0.1647 2.1751 -0.9858 3.7552 4.1115 0.4251 0.2897 0.1784 5.3932 1.7045</span> +<span class="r-out co"><span class="r-pr">#></span> 299: 93.8168 -6.0984 -0.1646 2.1754 -0.9856 3.7687 4.1143 0.4246 0.2902 0.1786 5.3949 1.7037</span> +<span class="r-out co"><span class="r-pr">#></span> 300: 93.8154 -6.0967 -0.1646 2.1756 -0.9855 3.7888 4.1072 0.4241 0.2906 0.1788 5.3962 1.7030</span> +<span class="r-out co"><span class="r-pr">#></span> 301: 93.8129 -6.0946 -0.1646 2.1757 -0.9852 3.8097 4.1006 0.4236 0.2911 0.1791 5.3971 1.7026</span> +<span class="r-out co"><span class="r-pr">#></span> 302: 93.8120 -6.0932 -0.1646 2.1759 -0.9849 3.8403 4.0955 0.4231 0.2917 0.1792 5.3971 1.7021</span> +<span class="r-out co"><span class="r-pr">#></span> 303: 93.8115 -6.0942 -0.1646 2.1762 -0.9850 3.8602 4.1004 0.4227 0.2922 0.1795 5.3976 1.7020</span> +<span class="r-out co"><span class="r-pr">#></span> 304: 93.8106 -6.0979 -0.1645 2.1765 -0.9850 3.8898 4.1217 0.4222 0.2926 0.1798 5.3975 1.7024</span> +<span class="r-out co"><span class="r-pr">#></span> 305: 93.8091 -6.1009 -0.1644 2.1767 -0.9851 3.9165 4.1374 0.4218 0.2931 0.1801 5.3989 1.7024</span> +<span class="r-out co"><span class="r-pr">#></span> 306: 93.8090 -6.1043 -0.1644 2.1770 -0.9850 3.9485 4.1617 0.4214 0.2936 0.1803 5.3998 1.7021</span> +<span class="r-out co"><span class="r-pr">#></span> 307: 93.8082 -6.1063 -0.1644 2.1772 -0.9850 3.9730 4.1797 0.4210 0.2940 0.1803 5.3998 1.7017</span> +<span class="r-out co"><span class="r-pr">#></span> 308: 93.8093 -6.1090 -0.1644 2.1775 -0.9850 3.9874 4.2026 0.4205 0.2945 0.1804 5.3996 1.7006</span> +<span class="r-out co"><span class="r-pr">#></span> 309: 93.8092 -6.1122 -0.1643 2.1777 -0.9849 3.9948 4.2297 0.4201 0.2948 0.1804 5.4001 1.6998</span> +<span class="r-out co"><span class="r-pr">#></span> 310: 93.8080 -6.1142 -0.1642 2.1780 -0.9850 3.9976 4.2436 0.4197 0.2951 0.1803 5.4016 1.6989</span> +<span class="r-out co"><span class="r-pr">#></span> 311: 93.8094 -6.1164 -0.1641 2.1784 -0.9851 4.0015 4.2552 0.4194 0.2952 0.1803 5.4033 1.6978</span> +<span class="r-out co"><span class="r-pr">#></span> 312: 93.8107 -6.1184 -0.1640 2.1788 -0.9851 4.0006 4.2628 0.4190 0.2954 0.1802 5.4042 1.6972</span> +<span class="r-out co"><span class="r-pr">#></span> 313: 93.8118 -6.1190 -0.1640 2.1789 -0.9851 3.9991 4.2638 0.4186 0.2955 0.1802 5.4053 1.6967</span> +<span class="r-out co"><span class="r-pr">#></span> 314: 93.8139 -6.1188 -0.1639 2.1791 -0.9851 4.0019 4.2619 0.4183 0.2956 0.1802 5.4049 1.6966</span> +<span class="r-out co"><span class="r-pr">#></span> 315: 93.8152 -6.1173 -0.1639 2.1792 -0.9851 4.0111 4.2553 0.4179 0.2957 0.1802 5.4052 1.6966</span> +<span class="r-out co"><span class="r-pr">#></span> 316: 93.8178 -6.1158 -0.1639 2.1792 -0.9851 4.0073 4.2498 0.4175 0.2957 0.1802 5.4050 1.6966</span> +<span class="r-out co"><span class="r-pr">#></span> 317: 93.8205 -6.1155 -0.1639 2.1792 -0.9851 3.9999 4.2491 0.4172 0.2957 0.1802 5.4048 1.6963</span> +<span class="r-out co"><span class="r-pr">#></span> 318: 93.8216 -6.1145 -0.1639 2.1792 -0.9850 3.9961 4.2438 0.4168 0.2957 0.1802 5.4031 1.6961</span> +<span class="r-out co"><span class="r-pr">#></span> 319: 93.8241 -6.1143 -0.1639 2.1792 -0.9849 4.0009 4.2412 0.4164 0.2958 0.1801 5.4004 1.6956</span> +<span class="r-out co"><span class="r-pr">#></span> 320: 93.8257 -6.1142 -0.1639 2.1792 -0.9849 4.0018 4.2380 0.4160 0.2958 0.1801 5.3986 1.6952</span> +<span class="r-out co"><span class="r-pr">#></span> 321: 93.8280 -6.1134 -0.1639 2.1792 -0.9849 4.0055 4.2339 0.4156 0.2959 0.1802 5.3966 1.6950</span> +<span class="r-out co"><span class="r-pr">#></span> 322: 93.8299 -6.1122 -0.1639 2.1793 -0.9848 4.0075 4.2274 0.4152 0.2959 0.1802 5.3969 1.6948</span> +<span class="r-out co"><span class="r-pr">#></span> 323: 93.8318 -6.1123 -0.1639 2.1794 -0.9848 4.0087 4.2257 0.4149 0.2960 0.1802 5.3980 1.6941</span> +<span class="r-out co"><span class="r-pr">#></span> 324: 93.8352 -6.1098 -0.1639 2.1795 -0.9848 4.0123 4.2136 0.4145 0.2960 0.1802 5.3988 1.6936</span> +<span class="r-out co"><span class="r-pr">#></span> 325: 93.8374 -6.1072 -0.1638 2.1796 -0.9848 4.0230 4.2005 0.4142 0.2961 0.1802 5.3991 1.6933</span> +<span class="r-out co"><span class="r-pr">#></span> 326: 93.8410 -6.1050 -0.1637 2.1796 -0.9849 4.0327 4.1891 0.4139 0.2963 0.1802 5.4004 1.6927</span> +<span class="r-out co"><span class="r-pr">#></span> 327: 93.8457 -6.1023 -0.1637 2.1796 -0.9849 4.0327 4.1767 0.4135 0.2964 0.1802 5.4013 1.6922</span> +<span class="r-out co"><span class="r-pr">#></span> 328: 93.8493 -6.1017 -0.1637 2.1797 -0.9850 4.0440 4.1730 0.4131 0.2964 0.1802 5.4019 1.6915</span> +<span class="r-out co"><span class="r-pr">#></span> 329: 93.8515 -6.1001 -0.1637 2.1799 -0.9851 4.0556 4.1648 0.4128 0.2963 0.1803 5.4017 1.6912</span> +<span class="r-out co"><span class="r-pr">#></span> 330: 93.8541 -6.1001 -0.1636 2.1800 -0.9852 4.0606 4.1631 0.4124 0.2962 0.1804 5.4025 1.6912</span> +<span class="r-out co"><span class="r-pr">#></span> 331: 93.8539 -6.0994 -0.1635 2.1801 -0.9854 4.0654 4.1584 0.4120 0.2961 0.1805 5.4025 1.6907</span> +<span class="r-out co"><span class="r-pr">#></span> 332: 93.8536 -6.0999 -0.1634 2.1803 -0.9854 4.0696 4.1601 0.4116 0.2960 0.1808 5.4027 1.6904</span> +<span class="r-out co"><span class="r-pr">#></span> 333: 93.8531 -6.1002 -0.1633 2.1806 -0.9853 4.0682 4.1646 0.4112 0.2960 0.1810 5.4038 1.6893</span> +<span class="r-out co"><span class="r-pr">#></span> 334: 93.8543 -6.1005 -0.1632 2.1809 -0.9852 4.0771 4.1690 0.4108 0.2960 0.1812 5.4040 1.6883</span> +<span class="r-out co"><span class="r-pr">#></span> 335: 93.8552 -6.1010 -0.1631 2.1813 -0.9851 4.0888 4.1775 0.4104 0.2960 0.1813 5.4044 1.6878</span> +<span class="r-out co"><span class="r-pr">#></span> 336: 93.8555 -6.1016 -0.1630 2.1817 -0.9850 4.0969 4.1858 0.4099 0.2961 0.1814 5.4046 1.6873</span> +<span class="r-out co"><span class="r-pr">#></span> 337: 93.8553 -6.1025 -0.1628 2.1820 -0.9849 4.1152 4.1921 0.4094 0.2962 0.1815 5.4070 1.6863</span> +<span class="r-out co"><span class="r-pr">#></span> 338: 93.8553 -6.1018 -0.1626 2.1824 -0.9848 4.1314 4.1904 0.4090 0.2963 0.1816 5.4080 1.6852</span> +<span class="r-out co"><span class="r-pr">#></span> 339: 93.8567 -6.1004 -0.1625 2.1828 -0.9847 4.1449 4.1855 0.4087 0.2964 0.1817 5.4087 1.6841</span> +<span class="r-out co"><span class="r-pr">#></span> 340: 93.8582 -6.0987 -0.1623 2.1832 -0.9846 4.1603 4.1799 0.4083 0.2965 0.1819 5.4086 1.6832</span> +<span class="r-out co"><span class="r-pr">#></span> 341: 93.8589 -6.0962 -0.1620 2.1836 -0.9844 4.1692 4.1694 0.4079 0.2965 0.1820 5.4102 1.6828</span> +<span class="r-out co"><span class="r-pr">#></span> 342: 93.8583 -6.0932 -0.1618 2.1841 -0.9844 4.1729 4.1563 0.4075 0.2966 0.1821 5.4117 1.6821</span> +<span class="r-out co"><span class="r-pr">#></span> 343: 93.8590 -6.0906 -0.1615 2.1845 -0.9844 4.1840 4.1447 0.4071 0.2966 0.1822 5.4125 1.6819</span> +<span class="r-out co"><span class="r-pr">#></span> 344: 93.8582 -6.0890 -0.1613 2.1851 -0.9845 4.1860 4.1347 0.4068 0.2968 0.1826 5.4135 1.6814</span> +<span class="r-out co"><span class="r-pr">#></span> 345: 93.8576 -6.0876 -0.1610 2.1857 -0.9846 4.1889 4.1252 0.4064 0.2969 0.1829 5.4143 1.6810</span> +<span class="r-out co"><span class="r-pr">#></span> 346: 93.8549 -6.0853 -0.1608 2.1862 -0.9845 4.1925 4.1121 0.4061 0.2969 0.1832 5.4157 1.6803</span> +<span class="r-out co"><span class="r-pr">#></span> 347: 93.8540 -6.0829 -0.1605 2.1867 -0.9845 4.2031 4.0990 0.4058 0.2970 0.1834 5.4158 1.6803</span> +<span class="r-out co"><span class="r-pr">#></span> 348: 93.8516 -6.0814 -0.1602 2.1873 -0.9845 4.2169 4.0885 0.4055 0.2971 0.1836 5.4174 1.6801</span> +<span class="r-out co"><span class="r-pr">#></span> 349: 93.8505 -6.0797 -0.1600 2.1879 -0.9845 4.2253 4.0779 0.4052 0.2971 0.1837 5.4190 1.6799</span> +<span class="r-out co"><span class="r-pr">#></span> 350: 93.8512 -6.0773 -0.1597 2.1885 -0.9845 4.2268 4.0657 0.4049 0.2972 0.1839 5.4209 1.6797</span> +<span class="r-out co"><span class="r-pr">#></span> 351: 93.8507 -6.0754 -0.1595 2.1890 -0.9845 4.2245 4.0559 0.4046 0.2972 0.1840 5.4230 1.6794</span> +<span class="r-out co"><span class="r-pr">#></span> 352: 93.8490 -6.0736 -0.1592 2.1896 -0.9845 4.2296 4.0474 0.4044 0.2973 0.1841 5.4252 1.6790</span> +<span class="r-out co"><span class="r-pr">#></span> 353: 93.8460 -6.0718 -0.1589 2.1901 -0.9845 4.2356 4.0374 0.4042 0.2973 0.1843 5.4272 1.6790</span> +<span class="r-out co"><span class="r-pr">#></span> 354: 93.8437 -6.0695 -0.1586 2.1906 -0.9845 4.2408 4.0255 0.4041 0.2973 0.1844 5.4303 1.6787</span> +<span class="r-out co"><span class="r-pr">#></span> 355: 93.8420 -6.0679 -0.1584 2.1912 -0.9844 4.2428 4.0166 0.4040 0.2973 0.1845 5.4342 1.6785</span> +<span class="r-out co"><span class="r-pr">#></span> 356: 93.8413 -6.0666 -0.1581 2.1916 -0.9843 4.2418 4.0072 0.4040 0.2973 0.1845 5.4348 1.6792</span> +<span class="r-out co"><span class="r-pr">#></span> 357: 93.8406 -6.0650 -0.1578 2.1921 -0.9844 4.2531 3.9973 0.4040 0.2973 0.1846 5.4350 1.6798</span> +<span class="r-out co"><span class="r-pr">#></span> 358: 93.8404 -6.0639 -0.1575 2.1926 -0.9844 4.2596 3.9901 0.4040 0.2973 0.1846 5.4357 1.6805</span> +<span class="r-out co"><span class="r-pr">#></span> 359: 93.8373 -6.0630 -0.1572 2.1931 -0.9845 4.2724 3.9820 0.4039 0.2973 0.1848 5.4368 1.6816</span> +<span class="r-out co"><span class="r-pr">#></span> 360: 93.8347 -6.0622 -0.1569 2.1936 -0.9845 4.2788 3.9747 0.4039 0.2973 0.1849 5.4377 1.6824</span> +<span class="r-out co"><span class="r-pr">#></span> 361: 93.8327 -6.0626 -0.1566 2.1942 -0.9846 4.2919 3.9749 0.4038 0.2973 0.1850 5.4382 1.6831</span> +<span class="r-out co"><span class="r-pr">#></span> 362: 93.8326 -6.0629 -0.1562 2.1947 -0.9846 4.2989 3.9737 0.4038 0.2973 0.1850 5.4408 1.6838</span> +<span class="r-out co"><span class="r-pr">#></span> 363: 93.8316 -6.0629 -0.1559 2.1953 -0.9846 4.3007 3.9725 0.4037 0.2972 0.1850 5.4420 1.6842</span> +<span class="r-out co"><span class="r-pr">#></span> 364: 93.8317 -6.0629 -0.1556 2.1957 -0.9846 4.2910 3.9739 0.4038 0.2971 0.1850 5.4430 1.6840</span> +<span class="r-out co"><span class="r-pr">#></span> 365: 93.8317 -6.0629 -0.1553 2.1962 -0.9846 4.2878 3.9759 0.4040 0.2967 0.1849 5.4441 1.6839</span> +<span class="r-out co"><span class="r-pr">#></span> 366: 93.8319 -6.0633 -0.1549 2.1966 -0.9845 4.2870 3.9823 0.4042 0.2963 0.1849 5.4461 1.6839</span> +<span class="r-out co"><span class="r-pr">#></span> 367: 93.8320 -6.0636 -0.1546 2.1971 -0.9845 4.2828 3.9850 0.4042 0.2959 0.1849 5.4479 1.6843</span> +<span class="r-out co"><span class="r-pr">#></span> 368: 93.8312 -6.0635 -0.1544 2.1975 -0.9844 4.2781 3.9859 0.4043 0.2955 0.1849 5.4475 1.6841</span> +<span class="r-out co"><span class="r-pr">#></span> 369: 93.8301 -6.0640 -0.1541 2.1979 -0.9844 4.2760 3.9891 0.4043 0.2953 0.1850 5.4472 1.6835</span> +<span class="r-out co"><span class="r-pr">#></span> 370: 93.8306 -6.0651 -0.1539 2.1983 -0.9844 4.2690 3.9967 0.4042 0.2950 0.1850 5.4484 1.6829</span> +<span class="r-out co"><span class="r-pr">#></span> 371: 93.8312 -6.0669 -0.1536 2.1988 -0.9845 4.2613 4.0111 0.4042 0.2947 0.1851 5.4494 1.6822</span> +<span class="r-out co"><span class="r-pr">#></span> 372: 93.8312 -6.0681 -0.1533 2.1992 -0.9845 4.2585 4.0252 0.4042 0.2945 0.1852 5.4513 1.6817</span> +<span class="r-out co"><span class="r-pr">#></span> 373: 93.8307 -6.0681 -0.1531 2.1996 -0.9846 4.2605 4.0284 0.4042 0.2943 0.1853 5.4523 1.6815</span> +<span class="r-out co"><span class="r-pr">#></span> 374: 93.8305 -6.0678 -0.1529 2.1999 -0.9846 4.2676 4.0279 0.4040 0.2942 0.1853 5.4533 1.6816</span> +<span class="r-out co"><span class="r-pr">#></span> 375: 93.8313 -6.0673 -0.1528 2.2002 -0.9846 4.2708 4.0232 0.4038 0.2940 0.1854 5.4543 1.6813</span> +<span class="r-out co"><span class="r-pr">#></span> 376: 93.8310 -6.0672 -0.1527 2.2004 -0.9846 4.2775 4.0214 0.4037 0.2938 0.1855 5.4538 1.6809</span> +<span class="r-out co"><span class="r-pr">#></span> 377: 93.8298 -6.0666 -0.1526 2.2007 -0.9846 4.2787 4.0166 0.4035 0.2937 0.1856 5.4532 1.6806</span> +<span class="r-out co"><span class="r-pr">#></span> 378: 93.8276 -6.0664 -0.1525 2.2009 -0.9846 4.2781 4.0135 0.4033 0.2935 0.1857 5.4538 1.6801</span> +<span class="r-out co"><span class="r-pr">#></span> 379: 93.8262 -6.0671 -0.1524 2.2012 -0.9846 4.2800 4.0157 0.4031 0.2932 0.1857 5.4530 1.6803</span> +<span class="r-out co"><span class="r-pr">#></span> 380: 93.8243 -6.0675 -0.1523 2.2015 -0.9846 4.2735 4.0168 0.4029 0.2929 0.1857 5.4523 1.6803</span> +<span class="r-out co"><span class="r-pr">#></span> 381: 93.8233 -6.0677 -0.1522 2.2017 -0.9845 4.2670 4.0189 0.4027 0.2926 0.1858 5.4517 1.6798</span> +<span class="r-out co"><span class="r-pr">#></span> 382: 93.8229 -6.0674 -0.1521 2.2019 -0.9845 4.2655 4.0211 0.4025 0.2924 0.1858 5.4510 1.6794</span> +<span class="r-out co"><span class="r-pr">#></span> 383: 93.8196 -6.0681 -0.1521 2.2021 -0.9843 4.2696 4.0291 0.4023 0.2922 0.1859 5.4504 1.6788</span> +<span class="r-out co"><span class="r-pr">#></span> 384: 93.8174 -6.0688 -0.1520 2.2023 -0.9842 4.2851 4.0333 0.4021 0.2919 0.1860 5.4500 1.6783</span> +<span class="r-out co"><span class="r-pr">#></span> 385: 93.8156 -6.0682 -0.1518 2.2028 -0.9840 4.3056 4.0305 0.4019 0.2920 0.1862 5.4503 1.6774</span> +<span class="r-out co"><span class="r-pr">#></span> 386: 93.8145 -6.0684 -0.1516 2.2032 -0.9838 4.3195 4.0302 0.4016 0.2920 0.1863 5.4499 1.6765</span> +<span class="r-out co"><span class="r-pr">#></span> 387: 93.8121 -6.0679 -0.1514 2.2036 -0.9837 4.3290 4.0272 0.4014 0.2920 0.1864 5.4501 1.6756</span> +<span class="r-out co"><span class="r-pr">#></span> 388: 93.8105 -6.0676 -0.1513 2.2040 -0.9835 4.3393 4.0267 0.4011 0.2920 0.1865 5.4509 1.6751</span> +<span class="r-out co"><span class="r-pr">#></span> 389: 93.8089 -6.0664 -0.1510 2.2045 -0.9833 4.3458 4.0224 0.4009 0.2920 0.1865 5.4512 1.6746</span> +<span class="r-out co"><span class="r-pr">#></span> 390: 93.8080 -6.0658 -0.1508 2.2049 -0.9832 4.3422 4.0199 0.4007 0.2920 0.1866 5.4514 1.6744</span> +<span class="r-out co"><span class="r-pr">#></span> 391: 93.8077 -6.0669 -0.1507 2.2053 -0.9831 4.3500 4.0277 0.4007 0.2920 0.1867 5.4511 1.6740</span> +<span class="r-out co"><span class="r-pr">#></span> 392: 93.8069 -6.0676 -0.1505 2.2056 -0.9831 4.3525 4.0326 0.4006 0.2920 0.1868 5.4500 1.6733</span> +<span class="r-out co"><span class="r-pr">#></span> 393: 93.8072 -6.0678 -0.1504 2.2059 -0.9830 4.3562 4.0344 0.4005 0.2920 0.1868 5.4491 1.6725</span> +<span class="r-out co"><span class="r-pr">#></span> 394: 93.8083 -6.0684 -0.1503 2.2061 -0.9829 4.3577 4.0386 0.4004 0.2920 0.1869 5.4493 1.6716</span> +<span class="r-out co"><span class="r-pr">#></span> 395: 93.8086 -6.0685 -0.1501 2.2064 -0.9828 4.3574 4.0394 0.4003 0.2920 0.1869 5.4493 1.6709</span> +<span class="r-out co"><span class="r-pr">#></span> 396: 93.8078 -6.0677 -0.1500 2.2067 -0.9827 4.3591 4.0355 0.4002 0.2921 0.1870 5.4493 1.6707</span> +<span class="r-out co"><span class="r-pr">#></span> 397: 93.8064 -6.0668 -0.1499 2.2071 -0.9825 4.3621 4.0317 0.4000 0.2922 0.1871 5.4495 1.6704</span> +<span class="r-out co"><span class="r-pr">#></span> 398: 93.8058 -6.0661 -0.1499 2.2073 -0.9823 4.3701 4.0285 0.3999 0.2923 0.1872 5.4491 1.6699</span> +<span class="r-out co"><span class="r-pr">#></span> 399: 93.8057 -6.0651 -0.1498 2.2075 -0.9822 4.3803 4.0243 0.3997 0.2924 0.1872 5.4485 1.6699</span> +<span class="r-out co"><span class="r-pr">#></span> 400: 93.8057 -6.0647 -0.1498 2.2076 -0.9820 4.3854 4.0225 0.3996 0.2924 0.1872 5.4488 1.6699</span> +<span class="r-out co"><span class="r-pr">#></span> 401: 93.8059 -6.0635 -0.1498 2.2078 -0.9819 4.3939 4.0178 0.3995 0.2925 0.1873 5.4491 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 402: 93.8063 -6.0621 -0.1498 2.2079 -0.9818 4.4033 4.0120 0.3993 0.2926 0.1875 5.4492 1.6704</span> +<span class="r-out co"><span class="r-pr">#></span> 403: 93.8055 -6.0609 -0.1498 2.2080 -0.9816 4.4098 4.0069 0.3992 0.2926 0.1876 5.4494 1.6703</span> +<span class="r-out co"><span class="r-pr">#></span> 404: 93.8040 -6.0608 -0.1499 2.2081 -0.9815 4.4153 4.0050 0.3991 0.2927 0.1877 5.4494 1.6701</span> +<span class="r-out co"><span class="r-pr">#></span> 405: 93.8030 -6.0604 -0.1499 2.2082 -0.9814 4.4181 4.0047 0.3990 0.2928 0.1879 5.4491 1.6700</span> +<span class="r-out co"><span class="r-pr">#></span> 406: 93.8002 -6.0597 -0.1499 2.2083 -0.9812 4.4257 4.0025 0.3989 0.2928 0.1880 5.4498 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 407: 93.7969 -6.0593 -0.1500 2.2085 -0.9810 4.4343 3.9994 0.3988 0.2928 0.1881 5.4514 1.6703</span> +<span class="r-out co"><span class="r-pr">#></span> 408: 93.7947 -6.0582 -0.1499 2.2087 -0.9809 4.4509 3.9936 0.3987 0.2927 0.1882 5.4526 1.6704</span> +<span class="r-out co"><span class="r-pr">#></span> 409: 93.7929 -6.0579 -0.1499 2.2088 -0.9807 4.4584 3.9918 0.3987 0.2926 0.1882 5.4537 1.6707</span> +<span class="r-out co"><span class="r-pr">#></span> 410: 93.7896 -6.0593 -0.1499 2.2089 -0.9807 4.4664 4.0002 0.3987 0.2925 0.1883 5.4560 1.6705</span> +<span class="r-out co"><span class="r-pr">#></span> 411: 93.7875 -6.0601 -0.1499 2.2090 -0.9807 4.4626 4.0057 0.3987 0.2924 0.1883 5.4567 1.6705</span> +<span class="r-out co"><span class="r-pr">#></span> 412: 93.7862 -6.0602 -0.1499 2.2091 -0.9808 4.4574 4.0095 0.3986 0.2923 0.1884 5.4565 1.6706</span> +<span class="r-out co"><span class="r-pr">#></span> 413: 93.7858 -6.0606 -0.1498 2.2092 -0.9808 4.4527 4.0146 0.3986 0.2922 0.1885 5.4561 1.6708</span> +<span class="r-out co"><span class="r-pr">#></span> 414: 93.7859 -6.0615 -0.1498 2.2093 -0.9808 4.4451 4.0211 0.3987 0.2921 0.1885 5.4574 1.6708</span> +<span class="r-out co"><span class="r-pr">#></span> 415: 93.7864 -6.0629 -0.1498 2.2092 -0.9808 4.4443 4.0298 0.3986 0.2921 0.1885 5.4576 1.6707</span> +<span class="r-out co"><span class="r-pr">#></span> 416: 93.7851 -6.0639 -0.1498 2.2092 -0.9808 4.4462 4.0362 0.3985 0.2920 0.1884 5.4575 1.6706</span> +<span class="r-out co"><span class="r-pr">#></span> 417: 93.7820 -6.0644 -0.1499 2.2092 -0.9808 4.4425 4.0387 0.3985 0.2920 0.1884 5.4577 1.6703</span> +<span class="r-out co"><span class="r-pr">#></span> 418: 93.7801 -6.0652 -0.1499 2.2093 -0.9808 4.4365 4.0420 0.3985 0.2920 0.1883 5.4589 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 419: 93.7799 -6.0648 -0.1499 2.2094 -0.9807 4.4303 4.0418 0.3984 0.2921 0.1883 5.4596 1.6703</span> +<span class="r-out co"><span class="r-pr">#></span> 420: 93.7797 -6.0641 -0.1498 2.2095 -0.9807 4.4216 4.0383 0.3983 0.2921 0.1884 5.4607 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 421: 93.7803 -6.0641 -0.1498 2.2096 -0.9808 4.4120 4.0396 0.3983 0.2922 0.1885 5.4621 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 422: 93.7806 -6.0638 -0.1498 2.2097 -0.9809 4.4017 4.0373 0.3981 0.2923 0.1885 5.4635 1.6702</span> +<span class="r-out co"><span class="r-pr">#></span> 423: 93.7800 -6.0636 -0.1498 2.2098 -0.9810 4.3948 4.0339 0.3981 0.2923 0.1885 5.4640 1.6701</span> +<span class="r-out co"><span class="r-pr">#></span> 424: 93.7789 -6.0638 -0.1498 2.2099 -0.9810 4.3884 4.0336 0.3980 0.2924 0.1885 5.4651 1.6700</span> +<span class="r-out co"><span class="r-pr">#></span> 425: 93.7774 -6.0628 -0.1498 2.2101 -0.9810 4.3814 4.0271 0.3978 0.2925 0.1884 5.4666 1.6699</span> +<span class="r-out co"><span class="r-pr">#></span> 426: 93.7755 -6.0619 -0.1498 2.2102 -0.9811 4.3841 4.0221 0.3977 0.2925 0.1884 5.4693 1.6697</span> +<span class="r-out co"><span class="r-pr">#></span> 427: 93.7753 -6.0612 -0.1498 2.2103 -0.9810 4.3785 4.0167 0.3975 0.2926 0.1883 5.4712 1.6696</span> +<span class="r-out co"><span class="r-pr">#></span> 428: 93.7741 -6.0613 -0.1498 2.2104 -0.9810 4.3767 4.0161 0.3973 0.2926 0.1882 5.4729 1.6696</span> +<span class="r-out co"><span class="r-pr">#></span> 429: 93.7717 -6.0613 -0.1498 2.2105 -0.9810 4.3744 4.0158 0.3971 0.2926 0.1880 5.4743 1.6694</span> +<span class="r-out co"><span class="r-pr">#></span> 430: 93.7690 -6.0619 -0.1498 2.2106 -0.9809 4.3744 4.0189 0.3969 0.2926 0.1879 5.4753 1.6692</span> +<span class="r-out co"><span class="r-pr">#></span> 431: 93.7668 -6.0615 -0.1498 2.2107 -0.9809 4.3709 4.0174 0.3967 0.2925 0.1878 5.4762 1.6691</span> +<span class="r-out co"><span class="r-pr">#></span> 432: 93.7656 -6.0619 -0.1498 2.2108 -0.9809 4.3710 4.0173 0.3966 0.2926 0.1878 5.4770 1.6688</span> +<span class="r-out co"><span class="r-pr">#></span> 433: 93.7632 -6.0625 -0.1498 2.2108 -0.9809 4.3689 4.0204 0.3964 0.2926 0.1877 5.4774 1.6687</span> +<span class="r-out co"><span class="r-pr">#></span> 434: 93.7624 -6.0621 -0.1498 2.2109 -0.9808 4.3687 4.0178 0.3962 0.2926 0.1876 5.4774 1.6683</span> +<span class="r-out co"><span class="r-pr">#></span> 435: 93.7608 -6.0622 -0.1497 2.2111 -0.9808 4.3714 4.0182 0.3961 0.2927 0.1875 5.4777 1.6679</span> +<span class="r-out co"><span class="r-pr">#></span> 436: 93.7586 -6.0622 -0.1498 2.2112 -0.9808 4.3695 4.0178 0.3959 0.2928 0.1874 5.4784 1.6679</span> +<span class="r-out co"><span class="r-pr">#></span> 437: 93.7558 -6.0622 -0.1498 2.2114 -0.9809 4.3658 4.0167 0.3957 0.2928 0.1873 5.4795 1.6678</span> +<span class="r-out co"><span class="r-pr">#></span> 438: 93.7519 -6.0627 -0.1499 2.2115 -0.9808 4.3601 4.0183 0.3955 0.2928 0.1872 5.4807 1.6674</span> +<span class="r-out co"><span class="r-pr">#></span> 439: 93.7478 -6.0618 -0.1499 2.2115 -0.9807 4.3538 4.0133 0.3952 0.2928 0.1871 5.4814 1.6672</span> +<span class="r-out co"><span class="r-pr">#></span> 440: 93.7449 -6.0612 -0.1499 2.2117 -0.9805 4.3504 4.0103 0.3951 0.2928 0.1870 5.4820 1.6669</span> +<span class="r-out co"><span class="r-pr">#></span> 441: 93.7433 -6.0608 -0.1499 2.2117 -0.9805 4.3438 4.0077 0.3949 0.2928 0.1869 5.4818 1.6666</span> +<span class="r-out co"><span class="r-pr">#></span> 442: 93.7417 -6.0604 -0.1500 2.2118 -0.9805 4.3354 4.0058 0.3947 0.2927 0.1868 5.4824 1.6666</span> +<span class="r-out co"><span class="r-pr">#></span> 443: 93.7407 -6.0604 -0.1500 2.2119 -0.9805 4.3281 4.0046 0.3946 0.2927 0.1867 5.4832 1.6667</span> +<span class="r-out co"><span class="r-pr">#></span> 444: 93.7397 -6.0608 -0.1500 2.2118 -0.9805 4.3180 4.0069 0.3944 0.2928 0.1866 5.4857 1.6664</span> +<span class="r-out co"><span class="r-pr">#></span> 445: 93.7387 -6.0613 -0.1501 2.2118 -0.9805 4.3092 4.0085 0.3942 0.2929 0.1866 5.4866 1.6663</span> +<span class="r-out co"><span class="r-pr">#></span> 446: 93.7376 -6.0612 -0.1502 2.2117 -0.9805 4.3022 4.0075 0.3939 0.2930 0.1865 5.4866 1.6660</span> +<span class="r-out co"><span class="r-pr">#></span> 447: 93.7375 -6.0613 -0.1503 2.2116 -0.9806 4.2981 4.0076 0.3937 0.2931 0.1865 5.4863 1.6658</span> +<span class="r-out co"><span class="r-pr">#></span> 448: 93.7388 -6.0617 -0.1504 2.2115 -0.9806 4.2970 4.0087 0.3935 0.2932 0.1864 5.4870 1.6658</span> +<span class="r-out co"><span class="r-pr">#></span> 449: 93.7400 -6.0617 -0.1504 2.2115 -0.9807 4.2904 4.0069 0.3933 0.2933 0.1864 5.4880 1.6655</span> +<span class="r-out co"><span class="r-pr">#></span> 450: 93.7414 -6.0623 -0.1505 2.2113 -0.9808 4.2829 4.0095 0.3930 0.2935 0.1863 5.4880 1.6653</span> +<span class="r-out co"><span class="r-pr">#></span> 451: 93.7426 -6.0634 -0.1506 2.2112 -0.9808 4.2797 4.0146 0.3928 0.2936 0.1863 5.4877 1.6655</span> +<span class="r-out co"><span class="r-pr">#></span> 452: 93.7447 -6.0642 -0.1507 2.2110 -0.9809 4.2770 4.0171 0.3926 0.2938 0.1862 5.4876 1.6657</span> +<span class="r-out co"><span class="r-pr">#></span> 453: 93.7465 -6.0644 -0.1508 2.2108 -0.9810 4.2698 4.0184 0.3924 0.2940 0.1862 5.4877 1.6652</span> +<span class="r-out co"><span class="r-pr">#></span> 454: 93.7478 -6.0645 -0.1509 2.2106 -0.9810 4.2657 4.0182 0.3922 0.2941 0.1861 5.4874 1.6648</span> +<span class="r-out co"><span class="r-pr">#></span> 455: 93.7486 -6.0650 -0.1511 2.2104 -0.9811 4.2656 4.0203 0.3921 0.2943 0.1861 5.4871 1.6644</span> +<span class="r-out co"><span class="r-pr">#></span> 456: 93.7485 -6.0659 -0.1512 2.2102 -0.9812 4.2646 4.0240 0.3920 0.2945 0.1860 5.4869 1.6641</span> +<span class="r-out co"><span class="r-pr">#></span> 457: 93.7487 -6.0668 -0.1514 2.2099 -0.9813 4.2613 4.0277 0.3919 0.2946 0.1860 5.4866 1.6640</span> +<span class="r-out co"><span class="r-pr">#></span> 458: 93.7484 -6.0667 -0.1515 2.2097 -0.9812 4.2586 4.0263 0.3918 0.2947 0.1859 5.4854 1.6639</span> +<span class="r-out co"><span class="r-pr">#></span> 459: 93.7468 -6.0661 -0.1517 2.2095 -0.9812 4.2565 4.0225 0.3917 0.2948 0.1858 5.4853 1.6639</span> +<span class="r-out co"><span class="r-pr">#></span> 460: 93.7458 -6.0652 -0.1518 2.2093 -0.9812 4.2548 4.0171 0.3916 0.2950 0.1858 5.4843 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 461: 93.7435 -6.0645 -0.1519 2.2091 -0.9811 4.2554 4.0121 0.3914 0.2951 0.1858 5.4843 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 462: 93.7421 -6.0637 -0.1521 2.2089 -0.9811 4.2509 4.0079 0.3913 0.2953 0.1857 5.4840 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 463: 93.7406 -6.0630 -0.1522 2.2088 -0.9810 4.2534 4.0036 0.3912 0.2955 0.1857 5.4834 1.6640</span> +<span class="r-out co"><span class="r-pr">#></span> 464: 93.7406 -6.0622 -0.1524 2.2086 -0.9810 4.2548 3.9986 0.3911 0.2956 0.1857 5.4828 1.6639</span> +<span class="r-out co"><span class="r-pr">#></span> 465: 93.7404 -6.0617 -0.1525 2.2084 -0.9810 4.2511 3.9955 0.3910 0.2958 0.1857 5.4828 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 466: 93.7414 -6.0610 -0.1527 2.2080 -0.9809 4.2468 3.9918 0.3910 0.2959 0.1857 5.4812 1.6640</span> +<span class="r-out co"><span class="r-pr">#></span> 467: 93.7419 -6.0606 -0.1529 2.2077 -0.9810 4.2446 3.9885 0.3909 0.2960 0.1858 5.4799 1.6642</span> +<span class="r-out co"><span class="r-pr">#></span> 468: 93.7427 -6.0604 -0.1531 2.2074 -0.9809 4.2473 3.9872 0.3909 0.2961 0.1858 5.4790 1.6643</span> +<span class="r-out co"><span class="r-pr">#></span> 469: 93.7435 -6.0608 -0.1532 2.2073 -0.9810 4.2457 3.9891 0.3907 0.2963 0.1858 5.4789 1.6641</span> +<span class="r-out co"><span class="r-pr">#></span> 470: 93.7442 -6.0611 -0.1533 2.2071 -0.9811 4.2443 3.9895 0.3905 0.2965 0.1858 5.4785 1.6640</span> +<span class="r-out co"><span class="r-pr">#></span> 471: 93.7443 -6.0618 -0.1534 2.2070 -0.9812 4.2415 3.9932 0.3903 0.2967 0.1858 5.4773 1.6639</span> +<span class="r-out co"><span class="r-pr">#></span> 472: 93.7433 -6.0624 -0.1535 2.2069 -0.9812 4.2414 3.9958 0.3901 0.2969 0.1858 5.4765 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 473: 93.7421 -6.0621 -0.1536 2.2067 -0.9811 4.2330 3.9962 0.3899 0.2970 0.1858 5.4762 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 474: 93.7415 -6.0621 -0.1537 2.2066 -0.9812 4.2263 3.9968 0.3897 0.2972 0.1858 5.4755 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 475: 93.7396 -6.0621 -0.1538 2.2066 -0.9812 4.2261 3.9956 0.3895 0.2973 0.1859 5.4751 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 476: 93.7373 -6.0626 -0.1539 2.2065 -0.9811 4.2265 3.9976 0.3893 0.2975 0.1859 5.4743 1.6634</span> +<span class="r-out co"><span class="r-pr">#></span> 477: 93.7357 -6.0623 -0.1540 2.2063 -0.9811 4.2222 3.9953 0.3891 0.2976 0.1859 5.4741 1.6635</span> +<span class="r-out co"><span class="r-pr">#></span> 478: 93.7345 -6.0620 -0.1541 2.2062 -0.9811 4.2165 3.9939 0.3889 0.2978 0.1860 5.4745 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 479: 93.7341 -6.0615 -0.1542 2.2062 -0.9812 4.2122 3.9916 0.3887 0.2979 0.1860 5.4751 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 480: 93.7338 -6.0619 -0.1543 2.2061 -0.9812 4.2084 3.9932 0.3885 0.2980 0.1860 5.4753 1.6635</span> +<span class="r-out co"><span class="r-pr">#></span> 481: 93.7336 -6.0618 -0.1544 2.2060 -0.9812 4.2066 3.9945 0.3883 0.2981 0.1860 5.4748 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 482: 93.7340 -6.0622 -0.1545 2.2058 -0.9812 4.2069 3.9969 0.3882 0.2983 0.1860 5.4741 1.6636</span> +<span class="r-out co"><span class="r-pr">#></span> 483: 93.7328 -6.0627 -0.1547 2.2057 -0.9813 4.2062 3.9992 0.3879 0.2985 0.1861 5.4739 1.6636</span> +<span class="r-out co"><span class="r-pr">#></span> 484: 93.7323 -6.0629 -0.1547 2.2056 -0.9813 4.2075 3.9995 0.3877 0.2987 0.1861 5.4730 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 485: 93.7326 -6.0634 -0.1548 2.2055 -0.9814 4.2045 4.0013 0.3875 0.2989 0.1862 5.4727 1.6637</span> +<span class="r-out co"><span class="r-pr">#></span> 486: 93.7320 -6.0632 -0.1549 2.2055 -0.9814 4.2084 3.9989 0.3872 0.2991 0.1863 5.4718 1.6635</span> +<span class="r-out co"><span class="r-pr">#></span> 487: 93.7321 -6.0625 -0.1549 2.2054 -0.9814 4.2105 3.9949 0.3870 0.2993 0.1864 5.4712 1.6634</span> +<span class="r-out co"><span class="r-pr">#></span> 488: 93.7326 -6.0623 -0.1550 2.2054 -0.9814 4.2104 3.9935 0.3868 0.2996 0.1865 5.4721 1.6635</span> +<span class="r-out co"><span class="r-pr">#></span> 489: 93.7342 -6.0615 -0.1551 2.2054 -0.9815 4.2103 3.9893 0.3866 0.2998 0.1866 5.4725 1.6635</span> +<span class="r-out co"><span class="r-pr">#></span> 490: 93.7360 -6.0610 -0.1551 2.2053 -0.9815 4.2116 3.9857 0.3864 0.3001 0.1867 5.4730 1.6636</span> +<span class="r-out co"><span class="r-pr">#></span> 491: 93.7374 -6.0601 -0.1551 2.2052 -0.9815 4.2128 3.9804 0.3862 0.3003 0.1868 5.4722 1.6638</span> +<span class="r-out co"><span class="r-pr">#></span> 492: 93.7386 -6.0597 -0.1552 2.2050 -0.9816 4.2171 3.9774 0.3861 0.3006 0.1869 5.4714 1.6642</span> +<span class="r-out co"><span class="r-pr">#></span> 493: 93.7399 -6.0597 -0.1553 2.2049 -0.9816 4.2262 3.9766 0.3859 0.3008 0.1869 5.4712 1.6643</span> +<span class="r-out co"><span class="r-pr">#></span> 494: 93.7404 -6.0596 -0.1553 2.2047 -0.9816 4.2347 3.9746 0.3857 0.3011 0.1870 5.4711 1.6646</span> +<span class="r-out co"><span class="r-pr">#></span> 495: 93.7406 -6.0590 -0.1554 2.2046 -0.9817 4.2395 3.9711 0.3855 0.3014 0.1871 5.4705 1.6650</span> +<span class="r-out co"><span class="r-pr">#></span> 496: 93.7416 -6.0582 -0.1554 2.2045 -0.9817 4.2456 3.9660 0.3853 0.3017 0.1871 5.4707 1.6656</span> +<span class="r-out co"><span class="r-pr">#></span> 497: 93.7433 -6.0575 -0.1555 2.2044 -0.9818 4.2511 3.9631 0.3851 0.3020 0.1871 5.4714 1.6658</span> +<span class="r-out co"><span class="r-pr">#></span> 498: 93.7444 -6.0574 -0.1556 2.2042 -0.9817 4.2516 3.9632 0.3848 0.3023 0.1871 5.4721 1.6660</span> +<span class="r-out co"><span class="r-pr">#></span> 499: 93.7457 -6.0576 -0.1557 2.2041 -0.9817 4.2518 3.9660 0.3846 0.3025 0.1871 5.4728 1.6660</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 93.7469 -6.0586 -0.1557 2.2040 -0.9817 4.2481 3.9757 0.3844 0.3028 0.1871 5.4738 1.6661</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta |sigma_parent | sigma_A1 | o1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 468.02617 | 1.000 | -1.000 | -0.9113 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.8511 | -0.8672 | -0.8762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8737 | -0.8674 | -0.8694 | -0.8687 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.02617 | 94.00 | -5.400 | -0.9900 | -0.2000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.000 | 1.200 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.189 | 1.093 | 1.127 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.02617</span> | 94.00 | 0.004517 | 0.2709 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 2.000 | 1.200 | 0.7536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.189 | 1.093 | 1.127 |</span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 49.30 | 2.016 | -0.2473 | -0.3737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.227 | -27.89 | -10.29 | 8.753 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.17 | -12.52 | -9.819 | -8.910 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 4021.4865 | 0.2059 | -1.032 | -0.9073 | -0.8894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8293 | -0.4019 | -0.7014 | -1.017 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.054 | -0.6658 | -0.7112 | -0.7251 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 4021.4865 | 19.35 | -5.432 | -0.9861 | -0.1940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.120 | 2.449 | 1.299 | 0.6474 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7182 | 1.429 | 1.266 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 4021.4865</span> | 19.35 | 0.004372 | 0.2717 | 0.8237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.329 | 2.449 | 1.299 | 0.6474 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7182 | 1.429 | 1.266 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 518.20369 | 0.9206 | -1.003 | -0.9109 | -0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.8062 | -0.8506 | -0.8903 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.8473 | -0.8535 | -0.8543 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 518.20369 | 86.53 | -5.403 | -0.9896 | -0.1994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.045 | 1.210 | 0.7430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.213 | 1.111 | 1.143 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 518.20369</span> | 86.53 | 0.004502 | 0.2710 | 0.8192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.182 | 2.045 | 1.210 | 0.7430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.213 | 1.111 | 1.143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 467.99742 | 0.9921 | -1.000 | -0.9112 | -0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.8466 | -0.8655 | -0.8776 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8755 | -0.8654 | -0.8678 | -0.8672 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.99742 | 93.25 | -5.400 | -0.9900 | -0.1999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.004 | 1.201 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8742 | 1.192 | 1.095 | 1.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.99742</span> | 93.25 | 0.004515 | 0.2709 | 0.8188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 2.004 | 1.201 | 0.7526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8742 | 1.192 | 1.095 | 1.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -98.28 | 1.929 | -0.4044 | -0.4503 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.484 | -29.27 | -9.987 | 8.922 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.417 | -11.79 | -9.521 | -8.343 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 467.67344 | 0.9967 | -1.000 | -0.9112 | -0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.8452 | -0.8651 | -0.8780 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8760 | -0.8648 | -0.8673 | -0.8668 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.67344 | 93.69 | -5.400 | -0.9899 | -0.1999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.006 | 1.201 | 0.7523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8738 | 1.192 | 1.095 | 1.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.67344</span> | 93.69 | 0.004515 | 0.2709 | 0.8188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 2.006 | 1.201 | 0.7523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8738 | 1.192 | 1.095 | 1.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.92 | 1.963 | -0.3242 | -0.4184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.350 | -28.16 | -10.02 | 8.541 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.305 | -11.80 | -9.512 | -8.408 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 467.50396 | 0.9983 | -1.001 | -0.9112 | -0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.8416 | -0.8638 | -0.8791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8771 | -0.8633 | -0.8661 | -0.8658 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.50396 | 93.84 | -5.401 | -0.9899 | -0.1999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.010 | 1.202 | 0.7514 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8729 | 1.194 | 1.097 | 1.130 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.50396</span> | 93.84 | 0.004514 | 0.2709 | 0.8188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 2.010 | 1.202 | 0.7514 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8729 | 1.194 | 1.097 | 1.130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 467.27231 | 1.003 | -1.001 | -0.9110 | -0.8951 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.8306 | -0.8599 | -0.8825 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8803 | -0.8587 | -0.8624 | -0.8625 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.27231 | 94.27 | -5.401 | -0.9898 | -0.1997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 2.021 | 1.204 | 0.7489 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8700 | 1.200 | 1.101 | 1.134 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.27231</span> | 94.27 | 0.004510 | 0.2710 | 0.8190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 2.021 | 1.204 | 0.7489 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8700 | 1.200 | 1.101 | 1.134 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 101.6 | 1.991 | -0.1997 | -0.3688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.177 | -25.72 | -9.853 | 9.249 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.335 | -11.58 | -9.288 | -8.277 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 466.36087 | 0.9961 | -1.002 | -0.9109 | -0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8474 | -0.8165 | -0.8547 | -0.8873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8853 | -0.8526 | -0.8575 | -0.8582 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.36087 | 93.63 | -5.402 | -0.9896 | -0.1995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.035 | 1.207 | 0.7453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8657 | 1.207 | 1.106 | 1.139 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.36087</span> | 93.63 | 0.004506 | 0.2710 | 0.8191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.180 | 2.035 | 1.207 | 0.7453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8657 | 1.207 | 1.106 | 1.139 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -21.78 | 1.909 | -0.3215 | -0.4291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.401 | -25.38 | -9.315 | 7.655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 10.17 | -11.26 | -9.035 | -7.894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 465.79764 | 1.000 | -1.004 | -0.9107 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.8024 | -0.8495 | -0.8920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.8462 | -0.8524 | -0.8537 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 465.79764 | 94.04 | -5.404 | -0.9895 | -0.1993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.049 | 1.211 | 0.7417 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.214 | 1.112 | 1.144 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 465.79764</span> | 94.04 | 0.004501 | 0.2710 | 0.8193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 2.049 | 1.211 | 0.7417 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.214 | 1.112 | 1.144 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.81 | 1.910 | -0.2489 | -0.4009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.285 | -22.17 | -8.389 | 8.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.340 | -11.02 | -8.786 | -7.720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 465.18897 | 0.9945 | -1.005 | -0.9105 | -0.8943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8457 | -0.7893 | -0.8445 | -0.8971 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8975 | -0.8390 | -0.8467 | -0.8487 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 465.18897 | 93.48 | -5.405 | -0.9893 | -0.1990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 2.062 | 1.214 | 0.7379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8549 | 1.223 | 1.118 | 1.149 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 465.18897</span> | 93.48 | 0.004495 | 0.2711 | 0.8196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.194 | 2.062 | 1.214 | 0.7379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8549 | 1.223 | 1.118 | 1.149 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -47.52 | 1.834 | -0.3684 | -0.4503 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.489 | -22.39 | -7.996 | 7.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.249 | -10.90 | -8.741 | -7.575 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 464.56229 | 0.9983 | -1.006 | -0.9102 | -0.8940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8445 | -0.7772 | -0.8401 | -0.9030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9029 | -0.8305 | -0.8400 | -0.8430 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 464.56229 | 93.84 | -5.406 | -0.9890 | -0.1986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.105 | 2.074 | 1.216 | 0.7334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8503 | 1.233 | 1.125 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 464.56229</span> | 93.84 | 0.004488 | 0.2711 | 0.8199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.204 | 2.074 | 1.216 | 0.7334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8503 | 1.233 | 1.125 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 463.71730 | 0.9982 | -1.009 | -0.9098 | -0.8933 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8424 | -0.7583 | -0.8332 | -0.9128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9112 | -0.8167 | -0.8291 | -0.8337 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 463.7173 | 93.83 | -5.409 | -0.9885 | -0.1980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.107 | 2.093 | 1.220 | 0.7260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 1.249 | 1.137 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 463.7173</span> | 93.83 | 0.004478 | 0.2712 | 0.8204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.221 | 2.093 | 1.220 | 0.7260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 1.249 | 1.137 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 461.03699 | 0.9978 | -1.018 | -0.9080 | -0.8909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8343 | -0.6839 | -0.8059 | -0.9516 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9441 | -0.7622 | -0.7862 | -0.7969 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 461.03699 | 93.79 | -5.418 | -0.9868 | -0.1955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.115 | 2.167 | 1.237 | 0.6968 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8141 | 1.314 | 1.184 | 1.208 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 461.03699</span> | 93.79 | 0.004435 | 0.2716 | 0.8224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.288 | 2.167 | 1.237 | 0.6968 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8141 | 1.314 | 1.184 | 1.208 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 458.83693 | 0.9972 | -1.033 | -0.9052 | -0.8871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8218 | -0.5692 | -0.7639 | -1.011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9948 | -0.6782 | -0.7201 | -0.7403 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.83693 | 93.74 | -5.433 | -0.9840 | -0.1917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.127 | 2.282 | 1.262 | 0.6519 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7697 | 1.414 | 1.256 | 1.272 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.83693</span> | 93.74 | 0.004371 | 0.2721 | 0.8255 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.393 | 2.282 | 1.262 | 0.6519 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7697 | 1.414 | 1.256 | 1.272 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.05416 | 1.397 | -0.2200 | -0.5344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.585 | -3.387 | -1.306 | -0.2250 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.392 | -3.452 | -2.065 | -1.405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 459.30045 | 0.9957 | -1.166 | -0.8845 | -0.8313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6584 | -0.5528 | -0.7505 | -0.8569 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.4560 | -0.6245 | -0.7036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 459.30045 | 93.60 | -5.566 | -0.9635 | -0.1360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | 2.298 | 1.270 | 0.7682 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7505 | 1.678 | 1.361 | 1.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 459.30045</span> | 93.60 | 0.003827 | 0.2762 | 0.8729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.881 | 2.298 | 1.270 | 0.7682 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7505 | 1.678 | 1.361 | 1.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 458.36319 | 0.9960 | -1.071 | -0.8992 | -0.8719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7770 | -0.5045 | -0.7383 | -0.9927 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.5931 | -0.6727 | -0.7107 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.36319 | 93.63 | -5.471 | -0.9780 | -0.1766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.172 | 2.347 | 1.277 | 0.6658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7452 | 1.515 | 1.308 | 1.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.36319</span> | 93.63 | 0.004206 | 0.2733 | 0.8381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.777 | 2.347 | 1.277 | 0.6658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7452 | 1.515 | 1.308 | 1.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.30 | 1.214 | 0.06343 | -0.2616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6069 | 0.08029 | 0.4273 | 0.07297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3937 | 0.3470 | 0.5201 | 0.09241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 458.37724 | 0.9977 | -1.183 | -0.9046 | -0.8476 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7196 | -0.4765 | -0.7567 | -1.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9850 | -0.5955 | -0.6985 | -0.7030 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.37724 | 93.79 | -5.583 | -0.9834 | -0.1522 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.229 | 2.375 | 1.266 | 0.6497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7783 | 1.513 | 1.280 | 1.314 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.37724</span> | 93.79 | 0.003762 | 0.2722 | 0.8588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.295 | 2.375 | 1.266 | 0.6497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7783 | 1.513 | 1.280 | 1.314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 458.32800 | 0.9976 | -1.124 | -0.9017 | -0.8605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7499 | -0.4913 | -0.7470 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.5943 | -0.6849 | -0.7071 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.328 | 93.78 | -5.524 | -0.9806 | -0.1651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.199 | 2.360 | 1.272 | 0.6583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7608 | 1.514 | 1.295 | 1.309 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.328</span> | 93.78 | 0.003990 | 0.2728 | 0.8478 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.017 | 2.360 | 1.272 | 0.6583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7608 | 1.514 | 1.295 | 1.309 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.757 | 1.093 | -0.06310 | 0.02237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09811 | 0.3115 | -0.3381 | -0.2098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8196 | 0.7052 | 0.04425 | 0.2610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 458.25889 | 0.9968 | -1.183 | -0.9011 | -0.8543 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7363 | -0.4871 | -0.7422 | -1.003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.6115 | -0.6911 | -0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.25889 | 93.70 | -5.583 | -0.9799 | -0.1589 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.213 | 2.364 | 1.275 | 0.6583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7450 | 1.494 | 1.288 | 1.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.25889</span> | 93.70 | 0.003760 | 0.2729 | 0.8531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.141 | 2.364 | 1.275 | 0.6583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7450 | 1.494 | 1.288 | 1.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.6125 | 0.8824 | -0.01905 | 0.1697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4368 | 0.4743 | 0.05191 | -0.6440 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4868 | -0.9136 | -0.3225 | -0.06220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 458.18570 | 0.9978 | -1.246 | -0.9006 | -0.8585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7495 | -0.4978 | -0.7385 | -0.9895 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6046 | -0.6874 | -0.7124 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1857 | 93.79 | -5.646 | -0.9794 | -0.1632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.200 | 2.353 | 1.277 | 0.6683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7440 | 1.502 | 1.292 | 1.303 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1857</span> | 93.79 | 0.003532 | 0.2730 | 0.8495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.022 | 2.353 | 1.277 | 0.6683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7440 | 1.502 | 1.292 | 1.303 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 458.13464 | 0.9963 | -1.435 | -0.8992 | -0.8705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7875 | -0.5278 | -0.7264 | -0.9531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6784 | -0.7184 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.13464 | 93.65 | -5.835 | -0.9781 | -0.1751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.323 | 1.284 | 0.6957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7378 | 1.519 | 1.302 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.13464</span> | 93.65 | 0.002922 | 0.2733 | 0.8394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.685 | 2.323 | 1.284 | 0.6957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7378 | 1.519 | 1.302 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.15 | 0.2290 | 0.2476 | -0.1455 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7111 | -1.138 | 0.8895 | 1.880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.837 | 0.2029 | 0.3485 | -0.6531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 458.67841 | 0.9992 | -1.651 | -0.9027 | -0.9245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8733 | -0.5209 | -0.7232 | -1.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.6164 | -0.6125 | -0.6771 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.67841 | 93.92 | -6.051 | -0.9815 | -0.2291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.076 | 2.330 | 1.286 | 0.6333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7647 | 1.488 | 1.374 | 1.343 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.67841</span> | 93.92 | 0.002355 | 0.2726 | 0.7952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.971 | 2.330 | 1.286 | 0.6333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7647 | 1.488 | 1.374 | 1.343 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 458.25487 | 1.002 | -1.469 | -0.8998 | -0.8789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8006 | -0.5263 | -0.7262 | -0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5942 | -0.6683 | -0.7117 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.25487 | 94.17 | -5.869 | -0.9787 | -0.1835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.148 | 2.325 | 1.285 | 0.6855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.514 | 1.313 | 1.304 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.25487</span> | 94.17 | 0.002825 | 0.2732 | 0.8324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.572 | 2.325 | 1.285 | 0.6855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.514 | 1.313 | 1.304 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 458.28425 | 1.002 | -1.442 | -0.8994 | -0.8721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7899 | -0.5271 | -0.7267 | -0.9564 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5910 | -0.6765 | -0.7168 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.28425 | 94.21 | -5.842 | -0.9783 | -0.1768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.159 | 2.324 | 1.284 | 0.6932 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.518 | 1.304 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.28425</span> | 94.21 | 0.002902 | 0.2732 | 0.8380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.664 | 2.324 | 1.284 | 0.6932 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.518 | 1.304 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 458.13208 | 0.9983 | -1.435 | -0.8993 | -0.8705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7874 | -0.5276 | -0.7266 | -0.9533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6785 | -0.7183 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.13208 | 93.84 | -5.835 | -0.9781 | -0.1751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.323 | 1.284 | 0.6955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7380 | 1.519 | 1.302 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.13208</span> | 93.84 | 0.002922 | 0.2733 | 0.8394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.686 | 2.323 | 1.284 | 0.6955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7380 | 1.519 | 1.302 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.75 | 0.2391 | 0.3431 | -0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6079 | -1.684 | 0.2301 | 1.587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9924 | -0.4675 | 0.3927 | -0.7567 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 458.12484 | 0.9973 | -1.435 | -0.8993 | -0.8705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7874 | -0.5275 | -0.7266 | -0.9535 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5900 | -0.6785 | -0.7182 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.12484 | 93.75 | -5.835 | -0.9782 | -0.1751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7379 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12484</span> | 93.75 | 0.002922 | 0.2733 | 0.8394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.686 | 2.324 | 1.284 | 0.6954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7379 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4576 | 0.2336 | 0.2904 | -0.1274 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6585 | -1.014 | 0.9040 | 1.932 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.695 | 0.2950 | 0.3980 | -0.7211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 458.12349 | 0.9975 | -1.436 | -0.8994 | -0.8704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7872 | -0.5272 | -0.7269 | -0.9542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6787 | -0.7180 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.12349 | 93.76 | -5.836 | -0.9783 | -0.1751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7384 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12349</span> | 93.76 | 0.002922 | 0.2732 | 0.8394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.688 | 2.324 | 1.284 | 0.6949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7384 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.734 | 0.2328 | 0.2907 | -0.1244 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6480 | -0.5259 | 1.203 | 2.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.687 | 0.2714 | 0.3976 | -0.7167 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 458.12069 | 0.9972 | -1.436 | -0.8995 | -0.8704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7868 | -0.5270 | -0.7278 | -0.9557 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5902 | -0.6785 | -0.7174 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.12069 | 93.74 | -5.836 | -0.9784 | -0.1750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6937 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12069</span> | 93.74 | 0.002921 | 0.2732 | 0.8394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.691 | 2.324 | 1.284 | 0.6937 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.995 | 0.2265 | 0.2648 | -0.1319 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6577 | -1.056 | 0.5532 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4851 | 0.2582 | 0.3806 | -0.6784 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 458.12793 | 0.9986 | -1.436 | -0.8997 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7863 | -0.5263 | -0.7282 | -0.9568 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7169 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.12793 | 93.87 | -5.836 | -0.9785 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6929 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12793</span> | 93.87 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.695 | 2.325 | 1.283 | 0.6929 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 458.12002 | 0.9975 | -1.436 | -0.8996 | -0.8704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7866 | -0.5269 | -0.7279 | -0.9559 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5903 | -0.6786 | -0.7173 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.12002 | 93.77 | -5.836 | -0.9784 | -0.1750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12002</span> | 93.77 | 0.002921 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.692 | 2.324 | 1.284 | 0.6935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.647 | 0.2293 | 0.2815 | -0.1267 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6372 | -0.9129 | 0.8290 | 1.823 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.624 | 0.2659 | 0.4184 | -0.6478 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 458.11922 | 0.9973 | -1.436 | -0.8996 | -0.8704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7866 | -0.5268 | -0.7280 | -0.9563 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5903 | -0.6786 | -0.7171 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11922 | 93.74 | -5.836 | -0.9784 | -0.1750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.324 | 1.284 | 0.6933 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7394 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11922</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.693 | 2.324 | 1.284 | 0.6933 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7394 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8024 | 0.2274 | 0.2665 | -0.1307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6475 | -1.019 | 0.5594 | 1.618 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.681 | 0.3232 | 0.3907 | -0.6658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 458.11869 | 0.9974 | -1.436 | -0.8996 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7864 | -0.5266 | -0.7281 | -0.9565 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6787 | -0.7170 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11869 | 93.76 | -5.836 | -0.9785 | -0.1750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.324 | 1.283 | 0.6931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11869</span> | 93.76 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.694 | 2.324 | 1.283 | 0.6931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.112 | 0.2271 | 0.2694 | -0.1286 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6401 | -1.529 | 0.3516 | 1.832 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3653 | 0.2635 | 0.3774 | -0.6589 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 458.11797 | 0.9972 | -1.436 | -0.8997 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7863 | -0.5263 | -0.7282 | -0.9569 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7169 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11797 | 93.74 | -5.836 | -0.9785 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11797</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.695 | 2.325 | 1.283 | 0.6928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.528 | 0.2260 | 0.2581 | -0.1311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6478 | -1.074 | 0.7096 | 1.705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.609 | 0.2690 | 0.3809 | -0.6419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 458.11744 | 0.9975 | -1.436 | -0.8997 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7862 | -0.5262 | -0.7283 | -0.9571 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7168 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11744 | 93.76 | -5.836 | -0.9786 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7399 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11744</span> | 93.76 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.696 | 2.325 | 1.283 | 0.6926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7399 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.737 | 0.2262 | 0.2659 | -0.1276 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6346 | -0.9458 | 0.5100 | 1.567 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.640 | 0.3111 | 0.3526 | -0.6225 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 458.11714 | 0.9972 | -1.436 | -0.8998 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7861 | -0.5260 | -0.7284 | -0.9574 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5905 | -0.6789 | -0.7167 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11714 | 93.74 | -5.836 | -0.9786 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6924 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7402 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11714</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.697 | 2.325 | 1.283 | 0.6924 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7402 | 1.519 | 1.302 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.976 | 0.2241 | 0.2491 | -0.1309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6467 | -0.8649 | 0.8521 | 1.757 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.585 | 0.2641 | 0.3618 | -0.6092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 458.11663 | 0.9975 | -1.436 | -0.8998 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7860 | -0.5259 | -0.7285 | -0.9576 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5905 | -0.6789 | -0.7166 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11663 | 93.76 | -5.836 | -0.9787 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11663</span> | 93.76 | 0.002920 | 0.2732 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.698 | 2.325 | 1.283 | 0.6923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.001 | 0.2249 | 0.2609 | -0.1271 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6310 | -0.8317 | 0.8110 | 1.745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3162 | 0.2564 | 0.3586 | -0.6097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 458.11610 | 0.9971 | -1.436 | -0.8999 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -0.5258 | -0.7286 | -0.9579 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6790 | -0.7165 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1161 | 93.73 | -5.836 | -0.9787 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1161</span> | 93.73 | 0.002920 | 0.2732 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.699 | 2.325 | 1.283 | 0.6920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.471 | 0.2228 | 0.2417 | -0.1310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6447 | -1.605 | 0.009434 | 1.531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.615 | 0.2909 | 0.3664 | -0.6093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 458.11531 | 0.9974 | -1.436 | -0.8999 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -0.5256 | -0.7287 | -0.9582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5905 | -0.6791 | -0.7164 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11531 | 93.76 | -5.836 | -0.9788 | -0.1749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6918 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7405 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11531</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.699 | 2.326 | 1.283 | 0.6918 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7405 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.540 | 0.2236 | 0.2522 | -0.1268 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6308 | -0.9638 | 0.7239 | 1.714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.540 | 0.2567 | 0.3599 | -0.5942 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 458.11496 | 0.9972 | -1.436 | -0.8999 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7858 | -0.5254 | -0.7288 | -0.9585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6791 | -0.7163 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11496 | 93.74 | -5.836 | -0.9788 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7408 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11496</span> | 93.74 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.700 | 2.326 | 1.283 | 0.6916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7408 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.772 | 0.2217 | 0.2376 | -0.1305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6412 | -1.736 | 0.1210 | 1.307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.540 | 0.2780 | 0.3483 | -0.5916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 458.11458 | 0.9975 | -1.436 | -0.9000 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7857 | -0.5252 | -0.7289 | -0.9587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6792 | -0.7163 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11458 | 93.76 | -5.836 | -0.9788 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6915 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7410 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11458</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.701 | 2.326 | 1.283 | 0.6915 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7410 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.896 | 0.2223 | 0.2476 | -0.1262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6268 | -0.4531 | 0.7600 | 1.698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.483 | 0.2984 | 0.3374 | -0.6006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 458.11430 | 0.9972 | -1.436 | -0.9000 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7856 | -0.5251 | -0.7290 | -0.9589 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6792 | -0.7162 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1143 | 93.73 | -5.836 | -0.9789 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1143</span> | 93.73 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.702 | 2.326 | 1.283 | 0.6913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.121 | 0.2201 | 0.2306 | -0.1307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6392 | -0.8820 | 0.4853 | 1.475 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.568 | 0.2856 | 0.3442 | -0.5942 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 458.11392 | 0.9975 | -1.437 | -0.9001 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7855 | -0.5250 | -0.7290 | -0.9592 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6793 | -0.7161 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11392 | 93.76 | -5.837 | -0.9789 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6911 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11392</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.702 | 2.326 | 1.283 | 0.6911 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.218 | 0.2203 | 0.2415 | -0.1269 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6242 | -1.700 | -0.1298 | 1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.097 | -0.4639 | 0.3406 | -0.5940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 458.11292 | 0.9972 | -1.437 | -0.9001 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7854 | -0.5247 | -0.7291 | -0.9594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6794 | -0.7160 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11292 | 93.74 | -5.837 | -0.9790 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11292</span> | 93.74 | 0.002919 | 0.2731 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.703 | 2.326 | 1.283 | 0.6909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.114 | 0.2202 | 0.2288 | -0.1307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6328 | -0.7727 | 0.7964 | 1.664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2569 | 0.2827 | 0.3132 | -0.5835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 458.11219 | 0.9975 | -1.437 | -0.9002 | -0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7853 | -0.5246 | -0.7293 | -0.9597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6795 | -0.7158 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11219 | 93.76 | -5.837 | -0.9790 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7413 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11219</span> | 93.76 | 0.002919 | 0.2731 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.704 | 2.327 | 1.283 | 0.6907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7413 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.924 | 0.2207 | 0.2357 | -0.1254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6202 | -0.4451 | 0.8288 | 1.643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.561 | 0.2786 | 0.3167 | -0.5797 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 458.11161 | 0.9972 | -1.437 | -0.9002 | -0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7852 | -0.5246 | -0.7295 | -0.9601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6795 | -0.7157 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11161 | 93.74 | -5.837 | -0.9791 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11161</span> | 93.74 | 0.002918 | 0.2731 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.705 | 2.327 | 1.283 | 0.6904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.221 | 0.2188 | 0.2217 | -0.1291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6301 | -1.629 | 0.1332 | 1.223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.491 | 0.2969 | 0.3215 | -0.5516 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 458.11130 | 0.9974 | -1.437 | -0.9003 | -0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7851 | -0.5243 | -0.7295 | -0.9603 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6796 | -0.7156 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1113 | 93.76 | -5.837 | -0.9791 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1113</span> | 93.76 | 0.002918 | 0.2731 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.706 | 2.327 | 1.283 | 0.6902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.605 | 0.2188 | 0.2279 | -0.1262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6191 | -1.596 | 0.1216 | 1.254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.158 | -0.4084 | 0.3005 | -0.5648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 458.11059 | 0.9972 | -1.437 | -0.9003 | -0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7850 | -0.5240 | -0.7295 | -0.9605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6796 | -0.7155 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11059 | 93.73 | -5.837 | -0.9791 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7415 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11059</span> | 93.73 | 0.002918 | 0.2731 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.707 | 2.327 | 1.283 | 0.6901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7415 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.022 | 0.2179 | 0.2140 | -0.1317 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6294 | -0.4112 | 0.8588 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.524 | 0.3410 | 0.3226 | -0.5400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 458.10995 | 0.9975 | -1.437 | -0.9003 | -0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7849 | -0.5239 | -0.7297 | -0.9608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6797 | -0.7154 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10995 | 93.76 | -5.837 | -0.9792 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10995</span> | 93.76 | 0.002918 | 0.2731 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.708 | 2.327 | 1.283 | 0.6899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.872 | 0.2188 | 0.2245 | -0.1278 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6141 | -1.055 | 0.5121 | 1.433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.504 | 0.3641 | 0.3235 | -0.5302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 458.10978 | 0.9972 | -1.437 | -0.9004 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7848 | -0.5238 | -0.7297 | -0.9610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6797 | -0.7153 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10978 | 93.73 | -5.837 | -0.9792 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.282 | 0.6897 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10978</span> | 93.73 | 0.002918 | 0.2730 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.709 | 2.327 | 1.282 | 0.6897 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.301 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.410 | 0.2142 | 0.1743 | -0.1457 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -0.7806 | 0.7426 | 1.188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06181 | -0.3659 | 0.5158 | -0.5913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 458.10914 | 0.9975 | -1.437 | -0.9004 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7847 | -0.5236 | -0.7299 | -0.9612 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6798 | -0.7152 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10914 | 93.77 | -5.837 | -0.9792 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.282 | 0.6895 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10914</span> | 93.77 | 0.002918 | 0.2730 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.709 | 2.327 | 1.282 | 0.6895 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.690 | 0.2171 | 0.2203 | -0.1291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6099 | -0.7940 | 0.4528 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.452 | 0.2831 | 0.2911 | -0.5300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 458.10832 | 0.9972 | -1.437 | -0.9004 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7846 | -0.5235 | -0.7300 | -0.9615 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5905 | -0.6799 | -0.7151 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10832 | 93.74 | -5.837 | -0.9793 | -0.1747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.328 | 1.282 | 0.6893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10832</span> | 93.74 | 0.002918 | 0.2730 | 0.8397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.710 | 2.328 | 1.282 | 0.6893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.386 | 0.2164 | 0.2066 | -0.1317 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6210 | -0.6390 | 0.8493 | 1.598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.491 | 0.2964 | 0.2278 | -0.4988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 458.10801 | 0.9974 | -1.437 | -0.9005 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7845 | -0.5234 | -0.7302 | -0.9618 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5906 | -0.6800 | -0.7150 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10801 | 93.76 | -5.837 | -0.9793 | -0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10801</span> | 93.76 | 0.002918 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.711 | 2.328 | 1.282 | 0.6891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.854 | 0.2167 | 0.2150 | -0.1282 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6083 | -0.7461 | 0.7029 | 1.539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1981 | 0.2733 | 0.2717 | -0.5257 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 458.10765 | 0.9971 | -1.437 | -0.9005 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7844 | -0.5232 | -0.7303 | -0.9621 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5906 | -0.6800 | -0.7149 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10765 | 93.73 | -5.837 | -0.9794 | -0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10765</span> | 93.73 | 0.002917 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.712 | 2.328 | 1.282 | 0.6889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.678 | 0.2148 | 0.1964 | -0.1329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6222 | -0.7140 | 0.5004 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2647 | 0.3470 | 0.3026 | -0.5041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 458.10677 | 0.9974 | -1.437 | -0.9006 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7843 | -0.5231 | -0.7305 | -0.9624 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7148 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10677 | 93.76 | -5.837 | -0.9794 | -0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6887 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10677</span> | 93.76 | 0.002917 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.713 | 2.328 | 1.282 | 0.6887 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.911 | 0.2164 | 0.2105 | -0.1281 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6034 | -0.7920 | 0.6471 | 1.488 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2445 | 0.2110 | 0.2380 | -0.4469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 458.10609 | 0.9972 | -1.437 | -0.9006 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7842 | -0.5230 | -0.7306 | -0.9627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7147 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10609 | 93.74 | -5.837 | -0.9794 | -0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10609</span> | 93.74 | 0.002917 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.714 | 2.328 | 1.282 | 0.6884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.589 | 0.2148 | 0.1951 | -0.1322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6145 | -0.8575 | 0.5942 | 1.427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.492 | 0.2699 | 0.1872 | -0.4796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 458.10567 | 0.9974 | -1.437 | -0.9006 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7841 | -0.5228 | -0.7308 | -0.9630 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7146 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10567 | 93.76 | -5.837 | -0.9795 | -0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10567</span> | 93.76 | 0.002917 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.715 | 2.328 | 1.282 | 0.6882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.760 | 0.2153 | 0.2043 | -0.1283 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6005 | -0.7529 | 0.6292 | 1.454 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2107 | 0.2534 | 0.2280 | -0.4318 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 458.10540 | 0.9971 | -1.437 | -0.9007 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7840 | -0.5227 | -0.7309 | -0.9633 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7146 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1054 | 93.73 | -5.837 | -0.9795 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1054</span> | 93.73 | 0.002917 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.716 | 2.328 | 1.282 | 0.6880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.789 | 0.2130 | 0.1850 | -0.1339 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6160 | -0.6903 | 0.7130 | 1.481 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1975 | 0.2824 | 0.2646 | -0.4868 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 458.10444 | 0.9974 | -1.437 | -0.9007 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7839 | -0.5226 | -0.7311 | -0.9636 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7145 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10444 | 93.76 | -5.837 | -0.9796 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10444</span> | 93.76 | 0.002916 | 0.2730 | 0.8398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.717 | 2.329 | 1.282 | 0.6878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.285 | 0.2143 | 0.1972 | -0.1290 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5987 | -0.7355 | 0.6064 | 1.421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.460 | 0.2526 | 0.2188 | -0.4206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 458.10435 | 0.9972 | -1.437 | -0.9008 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7838 | -0.5224 | -0.7312 | -0.9638 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6802 | -0.7144 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10435 | 93.73 | -5.837 | -0.9796 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10435</span> | 93.73 | 0.002916 | 0.2730 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.718 | 2.329 | 1.282 | 0.6876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.184 | 0.2097 | 0.1486 | -0.1446 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6255 | -0.7028 | 0.6444 | 1.495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.416 | 0.3010 | 0.4942 | -0.5303 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 458.10393 | 0.9975 | -1.438 | -0.9008 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7837 | -0.5223 | -0.7313 | -0.9641 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6802 | -0.7143 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10393 | 93.76 | -5.838 | -0.9796 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7426 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10393</span> | 93.76 | 0.002916 | 0.2730 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.718 | 2.329 | 1.282 | 0.6873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7426 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.045 | 0.2119 | 0.1940 | -0.1305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5955 | -0.7252 | 0.6285 | 1.413 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2070 | 0.2194 | 0.2208 | -0.3980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 458.10364 | 0.9971 | -1.438 | -0.9008 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7836 | -0.5222 | -0.7314 | -0.9644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6803 | -0.7142 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10364 | 93.73 | -5.838 | -0.9796 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10364</span> | 93.73 | 0.002916 | 0.2730 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.719 | 2.329 | 1.281 | 0.6871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.727 | 0.2108 | 0.1771 | -0.1339 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6094 | -0.7304 | 0.6317 | 1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.443 | 0.2644 | 0.2580 | -0.4629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 458.10286 | 0.9974 | -1.438 | -0.9008 | -0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7835 | -0.5221 | -0.7316 | -0.9647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6803 | -0.7141 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10286 | 93.75 | -5.838 | -0.9796 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10286</span> | 93.75 | 0.002915 | 0.2730 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.720 | 2.329 | 1.281 | 0.6869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.225 | 0.2118 | 0.1898 | -0.1294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5932 | -0.6493 | 0.6517 | 1.411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1402 | 0.3233 | 0.2428 | -0.3732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 458.10253 | 0.9971 | -1.438 | -0.9009 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7834 | -0.5219 | -0.7318 | -0.9650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6803 | -0.7141 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10253 | 93.73 | -5.838 | -0.9797 | -0.1745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10253</span> | 93.73 | 0.002915 | 0.2730 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.721 | 2.329 | 1.281 | 0.6867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.449 | 0.2099 | 0.1736 | -0.1338 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | -0.7015 | 0.6330 | 1.384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1863 | 0.2615 | 0.2563 | -0.4532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 458.10167 | 0.9974 | -1.438 | -0.9009 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7832 | -0.5218 | -0.7320 | -0.9653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7140 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10167 | 93.76 | -5.838 | -0.9797 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10167</span> | 93.76 | 0.002915 | 0.2729 | 0.8399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.722 | 2.329 | 1.281 | 0.6864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.422 | 0.2110 | 0.1849 | -0.1293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5889 | -0.5964 | 0.6731 | 1.405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1535 | 0.3114 | 0.2496 | -0.4521 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 458.10133 | 0.9971 | -1.438 | -0.9009 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7831 | -0.5217 | -0.7321 | -0.9657 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7139 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10133 | 93.73 | -5.838 | -0.9798 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10133</span> | 93.73 | 0.002915 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.723 | 2.329 | 1.281 | 0.6862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.461 | 0.2094 | 0.1688 | -0.1332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6003 | -0.7109 | 0.5914 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.404 | 0.2951 | 0.2552 | -0.4331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 458.10059 | 0.9974 | -1.438 | -0.9009 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7830 | -0.5215 | -0.7323 | -0.9660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7138 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10059 | 93.75 | -5.838 | -0.9798 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10059</span> | 93.75 | 0.002915 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.724 | 2.330 | 1.281 | 0.6860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.228 | 0.2101 | 0.1802 | -0.1294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5857 | -0.2287 | 0.9339 | 1.558 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.376 | 0.3488 | 0.2665 | -0.4324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 458.10050 | 0.9972 | -1.438 | -0.9010 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7829 | -0.5215 | -0.7325 | -0.9663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5910 | -0.6804 | -0.7137 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.1005 | 93.73 | -5.838 | -0.9798 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1005</span> | 93.73 | 0.002915 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.725 | 2.330 | 1.281 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.045 | 0.2058 | 0.1327 | -0.1461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6105 | -0.6040 | 0.6130 | 0.9518 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01902 | 0.3702 | 0.4676 | -0.4886 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 458.10013 | 0.9974 | -1.438 | -0.9010 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7829 | -0.5214 | -0.7325 | -0.9664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5910 | -0.6805 | -0.7136 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10013 | 93.75 | -5.838 | -0.9798 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10013</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.725 | 2.330 | 1.281 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.8557 | 0.2088 | 0.1747 | -0.1300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5847 | -0.2393 | 0.9114 | 1.536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.367 | 0.3016 | 0.2557 | -0.4123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 458.10002 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7828 | -0.5214 | -0.7326 | -0.9665 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6805 | -0.7136 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.10002 | 93.74 | -5.838 | -0.9798 | -0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7432 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10002</span> | 93.74 | 0.002914 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.726 | 2.330 | 1.281 | 0.6856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7432 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.5131 | 0.2058 | 0.1358 | -0.1441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6029 | -0.6262 | 0.5998 | 1.158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.373 | 0.3470 | 0.4566 | -0.4872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 458.09992 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7827 | -0.5214 | -0.7327 | -0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6806 | -0.7135 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.09992 | 93.75 | -5.838 | -0.9799 | -0.1743 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7433 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09992</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.726 | 2.330 | 1.281 | 0.6855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7433 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.2584 | 0.2056 | 0.1371 | -0.1438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5991 | -0.6198 | 0.6082 | 0.9676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.295 | 0.3221 | 0.4533 | -0.4750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 458.09944 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7827 | -0.5213 | -0.7328 | -0.9668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6806 | -0.7135 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.09944 | 93.75 | -5.838 | -0.9799 | -0.1743 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7431 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09944</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.727 | 2.330 | 1.281 | 0.6854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7431 | 1.518 | 1.300 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 458.09825 | 0.9974 | -1.438 | -0.9011 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7824 | -0.5210 | -0.7332 | -0.9672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6808 | -0.7131 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.09825 | 93.76 | -5.838 | -0.9799 | -0.1743 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.167 | 2.330 | 1.280 | 0.6851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.299 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09825</span> | 93.76 | 0.002914 | 0.2729 | 0.8401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.729 | 2.330 | 1.280 | 0.6851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.299 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 458.09793 | 0.9981 | -1.438 | -0.9013 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7815 | -0.5202 | -0.7349 | -0.9686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6812 | -0.7117 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.09793 | 93.82 | -5.838 | -0.9801 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.168 | 2.331 | 1.279 | 0.6840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.299 | 1.304 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09793</span> | 93.82 | 0.002913 | 0.2729 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.737 | 2.331 | 1.279 | 0.6840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.299 | 1.304 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.76 | 0.2116 | 0.1923 | -0.1162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5255 | -0.5796 | 0.3777 | 1.210 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.409 | 0.2855 | 0.1875 | -0.3085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 458.08987 | 0.9971 | -1.438 | -0.9013 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7808 | -0.5187 | -0.7369 | -0.9692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6832 | -0.7095 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08987 | 93.72 | -5.838 | -0.9802 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.168 | 2.332 | 1.278 | 0.6836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.297 | 1.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08987</span> | 93.72 | 0.002914 | 0.2729 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.743 | 2.332 | 1.278 | 0.6836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.297 | 1.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.512 | 0.2078 | 0.1434 | -0.1372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5667 | -0.8061 | 0.1467 | 1.033 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.202 | -0.4065 | 0.09417 | -0.1935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 458.08564 | 0.9973 | -1.438 | -0.9016 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7801 | -0.5170 | -0.7384 | -0.9704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5898 | -0.6859 | -0.7082 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08564 | 93.74 | -5.838 | -0.9804 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.169 | 2.334 | 1.277 | 0.6827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.519 | 1.294 | 1.308 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08564</span> | 93.74 | 0.002914 | 0.2728 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.749 | 2.334 | 1.277 | 0.6827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.519 | 1.294 | 1.308 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 458.08078 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7788 | -0.5136 | -0.7416 | -0.9727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5879 | -0.6916 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08078 | 93.73 | -5.838 | -0.9809 | -0.1742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.522 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08078</span> | 93.73 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.761 | 2.338 | 1.275 | 0.6809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.522 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8456 | 0.2109 | 0.1052 | -0.1453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5381 | -0.2225 | -0.1274 | 0.8336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2653 | 0.4698 | -0.4321 | 0.07917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 458.08109 | 0.9983 | -1.445 | -0.9066 | -0.8702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7727 | -0.5143 | -0.7362 | -0.9770 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5885 | -0.6915 | -0.7058 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08109 | 93.84 | -5.845 | -0.9853 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.176 | 2.337 | 1.279 | 0.6777 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.521 | 1.288 | 1.310 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08109</span> | 93.84 | 0.002894 | 0.2718 | 0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.815 | 2.337 | 1.279 | 0.6777 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.521 | 1.288 | 1.310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 458.08775 | 0.9985 | -1.441 | -0.9040 | -0.8696 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7757 | -0.5136 | -0.7393 | -0.9753 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5887 | -0.6911 | -0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08775 | 93.86 | -5.841 | -0.9828 | -0.1743 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.173 | 2.338 | 1.277 | 0.6789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08775</span> | 93.86 | 0.002906 | 0.2723 | 0.8401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.788 | 2.338 | 1.277 | 0.6789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 458.08407 | 0.9980 | -1.438 | -0.9022 | -0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7783 | -0.5133 | -0.7415 | -0.9736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5884 | -0.6912 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08407 | 93.81 | -5.838 | -0.9810 | -0.1740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08407</span> | 93.81 | 0.002915 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.766 | 2.338 | 1.275 | 0.6802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 458.08069 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08069 | 93.75 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08069</span> | 93.75 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.424 | 0.2112 | 0.1114 | -0.1426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5267 | -0.3290 | -0.02249 | 0.9218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.516 | 0.4273 | -0.4325 | 0.09748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 458.08076 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5134 | -0.7416 | -0.9730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6914 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08076 | 93.74 | -5.838 | -0.9810 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08076</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 458.08078 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08078 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08078</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 458.08068 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08068 | 93.75 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08068</span> | 93.75 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.7458 | 0.2086 | 0.07146 | -0.1568 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5453 | -0.1723 | 0.1066 | 0.6006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05957 | 0.1717 | -0.3314 | 0.06442 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 458.08065 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08065 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08065</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.5271 | 0.2085 | 0.07055 | -0.1570 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5454 | -0.3138 | 0.09492 | 0.7765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.192 | 0.4934 | -0.3382 | 0.1071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 458.08062 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08062 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08062</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.1077 | 0.2083 | 0.06880 | -0.1572 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5469 | -0.1727 | 0.1219 | 0.9565 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.457 | 0.5128 | -0.3399 | 0.1022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 458.08061 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08061 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08061</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.6930 | 0.2078 | 0.06712 | -0.1577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5484 | -0.1767 | 0.1148 | 0.9863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2038 | 0.5855 | -0.3296 | 0.1002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 458.08058 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08058 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08058</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.3701 | 0.2079 | 0.06808 | -0.1573 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5470 | -0.1729 | 0.005725 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.465 | 0.5101 | -0.1466 | -0.02770 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 458.08052 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7785 | -0.5135 | -0.7416 | -0.9731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08052 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08052</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.2062 | 0.2080 | 0.06837 | -0.1566 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | -0.1704 | 0.09858 | 0.5928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05984 | 0.5131 | -0.3447 | 0.06046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 458.08047 | 0.9972 | -1.438 | -0.9021 | -0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7785 | -0.5134 | -0.7416 | -0.9732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5882 | -0.6914 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08047 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08047</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.764 | 2.338 | 1.275 | 0.6805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.06148 | 0.2077 | 0.06828 | -0.1566 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5434 | -0.1748 | 0.1045 | 0.7316 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7607 | 0.4924 | -0.3350 | 0.1046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 458.08041 | 0.9972 | -1.438 | -0.9021 | -0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7784 | -0.5134 | -0.7417 | -0.9733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5883 | -0.6913 | -0.7054 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08041 | 93.74 | -5.838 | -0.9810 | -0.1740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6804 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08041</span> | 93.74 | 0.002915 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.765 | 2.338 | 1.275 | 0.6804 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.5076 | 0.2073 | 0.06528 | -0.1564 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5454 | -0.1802 | 0.1061 | 0.9740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1992 | 0.5430 | -0.2714 | 0.1031 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 458.08026 | 0.9972 | -1.438 | -0.9022 | -0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7782 | -0.5133 | -0.7417 | -0.9736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5884 | -0.6912 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08026 | 93.74 | -5.838 | -0.9810 | -0.1740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08026</span> | 93.74 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.766 | 2.338 | 1.275 | 0.6802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.3779 | 0.2092 | 0.07455 | -0.1547 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5349 | 0.4172 | -0.5362 | 0.7903 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.451 | 0.5182 | -0.2163 | -0.4361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 458.08039 | 0.9975 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7778 | -0.5133 | -0.7416 | -0.9742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5887 | -0.6910 | -0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08039 | 93.76 | -5.838 | -0.9811 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08039</span> | 93.76 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.769 | 2.338 | 1.275 | 0.6798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 458.08025 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08025 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08025</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 1.019 | 0.2066 | 0.06601 | -0.1530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5270 | -0.1637 | 0.1163 | 0.9184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.439 | 0.4715 | -0.2217 | 0.03756 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 458.08029 | 0.9972 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 458.08025 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08025 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08025</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 458.08029 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 458.08024 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08024 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08024</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.9275 | 0.2065 | 0.06562 | -0.1530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5278 | -0.1682 | 0.1168 | 0.9523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1838 | 0.4888 | -0.3154 | 0.09539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 458.08024 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08024 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08024</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.8715 | 0.2065 | 0.06540 | -0.1531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5308 | -0.07756 | 0.1164 | 0.5595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04465 | -0.2577 | -0.3240 | 0.1066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 458.08023 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08023 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08023</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 458.08013 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08013 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08013</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.7255 | 0.2064 | 0.06482 | -0.1531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5283 | -0.1617 | 0.1081 | 0.9192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.441 | 0.4906 | -0.2900 | 0.1161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 458.08017 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5885 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08017 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08017</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 458.08021 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08021 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08021</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 458.08029 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.75 | 0.002914 | 0.2727 | 0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 458.08033 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08033 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08033</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> 1: 93.0952 -5.6337 -1.8988 -4.1294 -1.2035 0.1038 5.2152 1.6150 1.0450 2.6377 0.5035 0.5225 20.0768 11.4566</span> +<span class="r-out co"><span class="r-pr">#></span> 2: 93.1464 -5.6948 -1.8729 -4.2029 -1.1302 0.1295 5.5478 1.5342 0.9927 2.5059 0.4783 0.5147 11.2089 8.1577</span> +<span class="r-out co"><span class="r-pr">#></span> 3: 93.1719 -5.7029 -1.8810 -4.2024 -1.0686 0.1063 5.2764 1.5217 0.9431 2.3806 0.4544 0.5587 9.3753 5.7166</span> +<span class="r-out co"><span class="r-pr">#></span> 4: 92.8647 -5.8139 -1.8979 -4.1992 -1.0168 0.1122 5.4892 1.7893 0.8960 2.2615 0.4317 0.5307 9.4134 4.7166</span> +<span class="r-out co"><span class="r-pr">#></span> 5: 92.7759 -5.8627 -1.8873 -4.1402 -1.0347 0.1243 6.2028 2.1819 0.8795 2.1485 0.4101 0.5042 9.5964 4.7340</span> +<span class="r-out co"><span class="r-pr">#></span> 6: 92.8080 -5.8954 -1.9186 -4.1772 -0.9727 0.1311 5.8926 2.0728 0.8633 2.0410 0.3896 0.4790 8.7334 4.1957</span> +<span class="r-out co"><span class="r-pr">#></span> 7: 92.9042 -5.9034 -1.9603 -4.1854 -0.9717 0.1630 5.5980 2.2068 0.8672 1.9390 0.3701 0.4550 8.7213 3.3409</span> +<span class="r-out co"><span class="r-pr">#></span> 8: 92.9302 -5.8545 -1.9240 -4.2343 -0.9748 0.1686 5.3181 2.3934 0.8239 1.9533 0.3516 0.4323 7.6950 2.9174</span> +<span class="r-out co"><span class="r-pr">#></span> 9: 92.9518 -5.5561 -1.9734 -4.1856 -0.9322 0.2129 5.0522 2.2738 0.7830 2.0138 0.3340 0.4689 7.9230 2.1930</span> +<span class="r-out co"><span class="r-pr">#></span> 10: 93.0672 -5.5564 -1.9633 -4.1456 -0.9343 0.2049 4.7996 2.1601 0.7438 2.0517 0.3173 0.4771 8.0644 2.0682</span> +<span class="r-out co"><span class="r-pr">#></span> 11: 92.6849 -5.6187 -1.9773 -4.1793 -0.9342 0.2290 4.5596 2.0521 0.7123 2.0774 0.3015 0.5052 8.2355 1.9349</span> +<span class="r-out co"><span class="r-pr">#></span> 12: 92.6425 -5.6989 -2.0144 -4.1395 -0.9342 0.2669 4.3316 2.2634 0.7142 2.3008 0.2864 0.5728 7.5188 1.8028</span> +<span class="r-out co"><span class="r-pr">#></span> 13: 92.2996 -5.6700 -1.9885 -4.0443 -0.9202 0.2750 4.5787 2.1608 0.7019 2.7515 0.2721 0.6641 7.0744 1.8958</span> +<span class="r-out co"><span class="r-pr">#></span> 14: 92.2457 -5.5825 -2.0314 -3.9788 -0.9142 0.2908 6.3744 2.0527 0.7018 3.2703 0.2585 0.6387 6.9499 1.8421</span> +<span class="r-out co"><span class="r-pr">#></span> 15: 92.1741 -5.5333 -2.0318 -3.9664 -0.9059 0.2894 6.0557 1.9501 0.7179 3.2869 0.2455 0.6068 7.0951 1.6824</span> +<span class="r-out co"><span class="r-pr">#></span> 16: 92.5772 -5.4982 -2.0352 -3.9471 -0.9063 0.2930 5.7529 1.8526 0.7244 3.6994 0.2333 0.5764 7.2138 1.7042</span> +<span class="r-out co"><span class="r-pr">#></span> 17: 92.7024 -5.4902 -2.0438 -4.0347 -0.9079 0.2959 5.4652 1.7600 0.7393 3.5144 0.2216 0.5765 7.0258 1.6793</span> +<span class="r-out co"><span class="r-pr">#></span> 18: 92.0240 -5.5539 -2.0520 -3.9601 -0.9079 0.2884 6.5142 1.9232 0.7320 3.9052 0.2157 0.5521 7.2568 1.6151</span> +<span class="r-out co"><span class="r-pr">#></span> 19: 92.6532 -5.6325 -2.0456 -3.9091 -0.9179 0.3047 6.5743 2.3363 0.7405 4.5825 0.2049 0.5425 7.6201 1.6565</span> +<span class="r-out co"><span class="r-pr">#></span> 20: 92.3488 -5.6617 -2.0554 -3.9501 -0.9216 0.3056 6.7080 2.7562 0.7218 4.7569 0.2083 0.5432 7.3481 1.8059</span> +<span class="r-out co"><span class="r-pr">#></span> 21: 92.5679 -5.7469 -2.0614 -4.0829 -0.8890 0.3158 6.6510 3.1993 0.7136 4.5191 0.1978 0.5281 7.3723 1.7461</span> +<span class="r-out co"><span class="r-pr">#></span> 22: 92.4785 -5.9527 -2.0657 -4.0580 -0.8971 0.3084 6.3184 4.1791 0.7144 4.2931 0.1929 0.5157 7.1922 1.6984</span> +<span class="r-out co"><span class="r-pr">#></span> 23: 92.5594 -5.8590 -2.0723 -4.0580 -0.9020 0.2952 6.0025 3.9702 0.7335 4.0784 0.1833 0.5129 7.7560 1.6302</span> +<span class="r-out co"><span class="r-pr">#></span> 24: 92.6152 -5.9488 -2.0658 -4.1187 -0.9050 0.2997 5.7024 4.5381 0.7215 3.8745 0.1875 0.5129 7.6182 1.6362</span> +<span class="r-out co"><span class="r-pr">#></span> 25: 92.4658 -5.8715 -2.0791 -4.0949 -0.8922 0.3074 6.1428 4.3112 0.7353 3.6808 0.1896 0.5157 7.2703 1.5633</span> +<span class="r-out co"><span class="r-pr">#></span> 26: 92.2507 -5.9797 -2.0707 -4.0834 -0.8868 0.3266 6.4124 4.7125 0.7334 3.5368 0.1851 0.5217 7.3085 1.5828</span> +<span class="r-out co"><span class="r-pr">#></span> 27: 92.7055 -5.9792 -2.0779 -4.2066 -0.8887 0.2993 6.0918 4.8624 0.7659 3.7456 0.1841 0.4956 7.3534 1.5240</span> +<span class="r-out co"><span class="r-pr">#></span> 28: 92.3971 -6.0253 -2.0648 -4.1406 -0.9042 0.2897 5.7872 4.7690 0.7449 3.5583 0.1823 0.4709 7.2479 1.5008</span> +<span class="r-out co"><span class="r-pr">#></span> 29: 92.4045 -5.9045 -2.0730 -4.1407 -0.8969 0.3103 5.6683 4.5306 0.7349 3.3816 0.1849 0.5054 7.1719 1.6004</span> +<span class="r-out co"><span class="r-pr">#></span> 30: 92.1714 -5.8598 -2.0645 -4.0913 -0.8964 0.2743 5.3849 4.3040 0.7538 3.3509 0.1757 0.4801 7.3739 1.5736</span> +<span class="r-out co"><span class="r-pr">#></span> 31: 91.9134 -5.7867 -2.0367 -4.0563 -0.8957 0.2280 5.1156 4.0888 0.7299 3.3452 0.1749 0.4673 6.5991 1.5909</span> +<span class="r-out co"><span class="r-pr">#></span> 32: 92.3743 -5.9967 -2.0255 -4.0668 -0.9025 0.2247 4.8599 4.6666 0.7256 3.3271 0.1714 0.5008 6.4693 1.5458</span> +<span class="r-out co"><span class="r-pr">#></span> 33: 92.5239 -5.9301 -2.0387 -4.0365 -0.9033 0.2558 4.6169 4.4333 0.7492 3.6109 0.1688 0.5424 6.7730 1.5771</span> +<span class="r-out co"><span class="r-pr">#></span> 34: 92.6892 -6.1135 -2.0587 -4.0280 -0.8993 0.2430 4.3860 6.0227 0.7798 3.5725 0.1672 0.5153 6.8110 1.5417</span> +<span class="r-out co"><span class="r-pr">#></span> 35: 92.7276 -6.0815 -2.0629 -4.0833 -0.8943 0.2375 4.6811 5.7216 0.8010 3.3939 0.1715 0.4895 6.6812 1.5478</span> +<span class="r-out co"><span class="r-pr">#></span> 36: 92.7316 -6.0691 -2.0882 -4.0626 -0.9030 0.2405 4.4614 5.4355 0.8355 3.2242 0.1789 0.4650 6.8443 1.4806</span> +<span class="r-out co"><span class="r-pr">#></span> 37: 92.6685 -5.7905 -2.0666 -4.0663 -0.8998 0.2784 5.1916 5.1637 0.7937 3.0641 0.1823 0.4418 6.5421 1.6284</span> +<span class="r-out co"><span class="r-pr">#></span> 38: 93.0325 -5.6829 -2.0674 -4.0772 -0.9167 0.2499 4.9320 4.9055 0.7768 3.1213 0.1887 0.4290 6.8220 1.5224</span> +<span class="r-out co"><span class="r-pr">#></span> 39: 93.0378 -5.5554 -2.0743 -4.0772 -0.9189 0.2361 4.6854 4.6603 0.7822 3.1213 0.1813 0.4242 7.1137 1.5021</span> +<span class="r-out co"><span class="r-pr">#></span> 40: 93.3297 -5.6270 -2.0591 -4.1200 -0.9167 0.2035 4.4511 4.4272 0.8128 2.9653 0.1829 0.4030 7.3894 1.5064</span> +<span class="r-out co"><span class="r-pr">#></span> 41: 93.3408 -5.5437 -2.0344 -4.1042 -0.9078 0.1744 4.2286 4.2059 0.8228 2.8170 0.1881 0.3829 7.2734 1.5519</span> +<span class="r-out co"><span class="r-pr">#></span> 42: 93.1691 -5.4436 -2.0551 -4.1048 -0.8984 0.1732 4.0172 3.9956 0.7816 2.6762 0.1853 0.3637 6.9712 1.5332</span> +<span class="r-out co"><span class="r-pr">#></span> 43: 93.2443 -5.5247 -2.0722 -4.0980 -0.8992 0.1756 3.8163 3.7958 0.7781 2.7200 0.1956 0.3455 6.7012 1.5344</span> +<span class="r-out co"><span class="r-pr">#></span> 44: 92.9509 -5.5020 -2.0495 -4.0961 -0.8964 0.1777 3.6255 3.6060 0.7555 2.8172 0.1994 0.3283 6.2180 1.6137</span> +<span class="r-out co"><span class="r-pr">#></span> 45: 92.8898 -5.4913 -2.0462 -4.1079 -0.9003 0.1701 4.1177 3.4257 0.7491 2.8491 0.1989 0.3372 6.2876 1.6205</span> +<span class="r-out co"><span class="r-pr">#></span> 46: 92.6044 -5.6429 -2.0499 -4.1079 -0.9069 0.1999 4.2103 3.2544 0.7657 2.8491 0.1921 0.3532 6.2261 1.6435</span> +<span class="r-out co"><span class="r-pr">#></span> 47: 92.7740 -5.6128 -2.0804 -4.1186 -0.8976 0.1864 5.2188 3.0917 0.7381 2.9036 0.2030 0.3391 6.6803 1.6177</span> +<span class="r-out co"><span class="r-pr">#></span> 48: 92.4691 -5.6645 -2.0600 -4.1288 -0.8796 0.1913 6.2045 2.9371 0.7774 2.9223 0.1966 0.3396 6.7169 1.6215</span> +<span class="r-out co"><span class="r-pr">#></span> 49: 92.4128 -5.7079 -2.0802 -4.1166 -0.8798 0.1741 5.8943 3.1446 0.7854 2.8715 0.1935 0.3369 6.9151 1.4834</span> +<span class="r-out co"><span class="r-pr">#></span> 50: 91.8883 -5.7713 -2.0932 -4.0899 -0.8886 0.1758 5.5996 3.5478 0.8033 2.8192 0.2014 0.3201 7.0775 1.4635</span> +<span class="r-out co"><span class="r-pr">#></span> 51: 92.1187 -5.7306 -2.0903 -4.0878 -0.8923 0.2024 5.3196 3.6534 0.7823 2.7891 0.1969 0.3140 6.9879 1.5430</span> +<span class="r-out co"><span class="r-pr">#></span> 52: 92.3209 -5.7897 -2.0903 -4.1622 -0.9072 0.2261 5.3781 3.4707 0.8001 3.0801 0.2063 0.3088 6.7047 1.4499</span> +<span class="r-out co"><span class="r-pr">#></span> 53: 92.4318 -5.6954 -2.0950 -4.1866 -0.9082 0.2131 7.1200 3.2972 0.7711 3.3398 0.2034 0.3186 6.6152 1.5123</span> +<span class="r-out co"><span class="r-pr">#></span> 54: 92.5380 -5.6975 -2.0782 -4.2394 -0.8976 0.2118 6.7640 3.1323 0.7744 3.5385 0.2175 0.3296 6.4402 1.5403</span> +<span class="r-out co"><span class="r-pr">#></span> 55: 92.7213 -5.6663 -2.0427 -4.3288 -0.9028 0.2032 8.1796 2.9757 0.7748 4.4495 0.2142 0.3316 6.4111 1.5369</span> +<span class="r-out co"><span class="r-pr">#></span> 56: 92.7219 -5.6865 -2.0557 -4.3434 -0.9084 0.2021 7.7706 2.8269 0.7989 4.6691 0.2174 0.3433 6.4256 1.4639</span> +<span class="r-out co"><span class="r-pr">#></span> 57: 92.8932 -5.5736 -2.0497 -4.3955 -0.9216 0.1694 7.3821 2.6856 0.8205 4.9791 0.2142 0.3500 6.5378 1.5406</span> +<span class="r-out co"><span class="r-pr">#></span> 58: 92.9219 -5.5789 -2.0547 -4.3094 -0.9183 0.1838 7.0130 2.5513 0.7958 4.7302 0.2193 0.3495 6.2662 1.4940</span> +<span class="r-out co"><span class="r-pr">#></span> 59: 93.0432 -5.6201 -2.0395 -4.2527 -0.9199 0.2302 6.6623 2.4237 0.8241 4.4937 0.2241 0.3321 5.8693 1.6176</span> +<span class="r-out co"><span class="r-pr">#></span> 60: 92.9724 -5.5971 -2.0537 -4.3509 -0.9219 0.2118 7.5905 2.3026 0.8418 4.4546 0.2177 0.3155 5.5960 1.5040</span> +<span class="r-out co"><span class="r-pr">#></span> 61: 93.1235 -5.6332 -2.0671 -4.3572 -0.9219 0.1917 7.2521 2.3037 0.8527 4.5707 0.2230 0.2997 5.8136 1.4516</span> +<span class="r-out co"><span class="r-pr">#></span> 62: 93.5431 -5.6373 -2.0371 -4.3384 -0.9276 0.1997 8.5187 2.3895 0.8575 4.4378 0.2258 0.3041 5.5746 1.4572</span> +<span class="r-out co"><span class="r-pr">#></span> 63: 93.5009 -5.5634 -2.0224 -4.3560 -0.9339 0.2167 8.0927 2.2700 0.8462 4.4449 0.2266 0.3162 5.4922 1.5233</span> +<span class="r-out co"><span class="r-pr">#></span> 64: 93.7369 -5.6032 -2.0362 -4.2323 -0.9355 0.2159 9.6684 2.1949 0.8514 4.2227 0.2300 0.3318 5.7597 1.4866</span> +<span class="r-out co"><span class="r-pr">#></span> 65: 93.5021 -5.5769 -2.0311 -4.3204 -0.9375 0.1927 9.5537 2.0852 0.8559 4.6151 0.2208 0.3550 5.6975 1.5031</span> +<span class="r-out co"><span class="r-pr">#></span> 66: 93.4211 -5.7184 -2.0384 -4.3041 -0.9228 0.2121 9.0760 2.6390 0.8430 4.3843 0.2098 0.3755 5.8990 1.5133</span> +<span class="r-out co"><span class="r-pr">#></span> 67: 93.3435 -5.6579 -2.0456 -4.2222 -0.9183 0.1825 8.6222 2.5071 0.8719 4.1651 0.2152 0.3567 5.9004 1.4874</span> +<span class="r-out co"><span class="r-pr">#></span> 68: 93.3914 -5.6554 -2.0420 -4.1618 -0.9303 0.1714 8.1911 2.3817 0.8856 3.9569 0.2272 0.3388 6.1793 1.4917</span> +<span class="r-out co"><span class="r-pr">#></span> 69: 93.5112 -5.6834 -2.0349 -4.1591 -0.9331 0.1759 8.9900 2.5191 0.9184 3.7590 0.2236 0.3219 6.1618 1.4697</span> +<span class="r-out co"><span class="r-pr">#></span> 70: 93.4289 -5.6576 -2.0273 -4.1763 -0.9399 0.1738 8.5405 2.4302 0.8725 3.5711 0.2149 0.3288 6.5324 1.5410</span> +<span class="r-out co"><span class="r-pr">#></span> 71: 93.2936 -5.6699 -2.0256 -4.1405 -0.9370 0.1922 8.1134 2.3831 0.8289 3.3925 0.2080 0.3548 5.9794 1.5904</span> +<span class="r-out co"><span class="r-pr">#></span> 72: 92.9152 -5.6742 -2.0382 -4.1523 -0.9411 0.1991 7.7078 2.4322 0.7875 3.2916 0.2007 0.3456 6.0999 1.6022</span> +<span class="r-out co"><span class="r-pr">#></span> 73: 92.8129 -5.8099 -2.0372 -4.1735 -0.9377 0.1605 8.2752 2.8931 0.7737 3.4015 0.2057 0.3283 6.0140 1.5472</span> +<span class="r-out co"><span class="r-pr">#></span> 74: 92.7806 -5.7269 -2.0315 -4.1877 -0.9399 0.1675 8.4688 2.7484 0.7773 3.4620 0.2174 0.3249 5.8495 1.5779</span> +<span class="r-out co"><span class="r-pr">#></span> 75: 92.9128 -5.8680 -2.0304 -4.1459 -0.9387 0.1567 8.0454 3.2365 0.7681 3.2935 0.2198 0.3187 5.8539 1.5815</span> +<span class="r-out co"><span class="r-pr">#></span> 76: 92.8931 -5.8483 -2.0253 -4.1815 -0.9387 0.1540 9.6800 3.0747 0.8007 3.5838 0.2198 0.3291 5.9005 1.5053</span> +<span class="r-out co"><span class="r-pr">#></span> 77: 92.7474 -5.7995 -2.0202 -4.1904 -0.9333 0.1724 10.0488 2.9210 0.7841 3.7255 0.2148 0.3465 5.9418 1.5569</span> +<span class="r-out co"><span class="r-pr">#></span> 78: 92.8150 -5.9608 -2.0025 -4.1583 -0.9511 0.1566 9.5464 3.5249 0.7858 3.6988 0.2246 0.3292 5.7737 1.5904</span> +<span class="r-out co"><span class="r-pr">#></span> 79: 92.6663 -6.0485 -2.0245 -4.1437 -0.9446 0.1786 9.0690 4.1252 0.7803 3.6526 0.2155 0.3335 5.9109 1.5521</span> +<span class="r-out co"><span class="r-pr">#></span> 80: 92.5932 -6.1001 -2.0304 -4.1969 -0.9409 0.1424 8.6156 4.6478 0.8007 4.0379 0.2114 0.3168 6.1732 1.5544</span> +<span class="r-out co"><span class="r-pr">#></span> 81: 92.6789 -6.3510 -2.0062 -4.2272 -0.9541 0.1360 8.3363 5.9861 0.7719 3.8800 0.2202 0.3010 5.6841 1.6317</span> +<span class="r-out co"><span class="r-pr">#></span> 82: 92.9996 -6.5680 -2.0048 -4.1609 -0.9578 0.1367 10.6901 7.4391 0.7962 3.6860 0.2092 0.2859 5.7335 1.6391</span> +<span class="r-out co"><span class="r-pr">#></span> 83: 93.1087 -6.5298 -1.9757 -4.1694 -0.9596 0.1323 10.5524 7.4660 0.8237 3.8009 0.2134 0.2716 5.9664 1.6316</span> +<span class="r-out co"><span class="r-pr">#></span> 84: 93.1929 -6.5844 -2.0191 -4.2021 -0.9616 0.1384 10.0248 7.7313 0.8230 3.6109 0.2110 0.2580 5.7854 1.5609</span> +<span class="r-out co"><span class="r-pr">#></span> 85: 92.9161 -6.4934 -2.0281 -4.2008 -0.9600 0.1107 9.5236 7.4269 0.8448 3.5630 0.2110 0.2451 5.6111 1.5333</span> +<span class="r-out co"><span class="r-pr">#></span> 86: 92.9816 -6.5397 -2.0234 -4.1830 -0.9694 0.1111 9.1945 7.4382 0.8481 3.3849 0.2166 0.2329 5.8375 1.5263</span> +<span class="r-out co"><span class="r-pr">#></span> 87: 93.0930 -6.5749 -2.0168 -4.1986 -0.9816 0.0926 8.7348 8.4431 0.8646 3.3032 0.2155 0.2212 5.7542 1.5736</span> +<span class="r-out co"><span class="r-pr">#></span> 88: 93.0765 -6.4914 -2.0274 -4.2274 -0.9870 0.1148 8.4666 8.0209 0.8666 3.5292 0.2048 0.2102 5.8988 1.5329</span> +<span class="r-out co"><span class="r-pr">#></span> 89: 92.8699 -6.6431 -2.0199 -4.2175 -0.9463 0.1011 8.4648 7.7973 0.8908 3.3980 0.1945 0.2102 5.6876 1.5177</span> +<span class="r-out co"><span class="r-pr">#></span> 90: 92.8225 -6.6932 -2.0211 -4.2175 -0.9505 0.0887 10.1862 8.7787 0.8730 3.3980 0.1877 0.1997 5.9135 1.4821</span> +<span class="r-out co"><span class="r-pr">#></span> 91: 92.7874 -6.7007 -2.0420 -4.2936 -0.9468 0.0927 11.2275 8.3397 0.8600 3.9490 0.1885 0.2147 6.1108 1.4315</span> +<span class="r-out co"><span class="r-pr">#></span> 92: 93.2320 -6.8088 -2.0341 -4.2817 -0.9582 0.1270 12.4029 9.6204 0.8503 3.7516 0.1950 0.2070 5.9434 1.5251</span> +<span class="r-out co"><span class="r-pr">#></span> 93: 93.8996 -6.5471 -2.0440 -4.2123 -0.9543 0.1140 11.7828 9.1394 0.8493 3.5640 0.1988 0.2017 6.1302 1.5568</span> +<span class="r-out co"><span class="r-pr">#></span> 94: 93.4416 -6.4623 -2.0448 -4.2188 -0.9595 0.1174 12.1277 8.6824 0.8568 3.3858 0.1975 0.1938 5.9173 1.5204</span> +<span class="r-out co"><span class="r-pr">#></span> 95: 93.2953 -6.1521 -2.0477 -4.2216 -0.9551 0.1152 11.5213 8.2483 0.8356 3.2165 0.1979 0.1855 5.8298 1.5357</span> +<span class="r-out co"><span class="r-pr">#></span> 96: 92.9577 -6.0477 -2.0579 -4.2534 -0.9465 0.1284 10.9452 7.8359 0.8202 3.3357 0.1937 0.1917 5.8590 1.5738</span> +<span class="r-out co"><span class="r-pr">#></span> 97: 92.8703 -6.1037 -2.0745 -4.1960 -0.9405 0.1417 10.4858 7.4441 0.8488 3.1690 0.1969 0.2016 5.7948 1.4759</span> +<span class="r-out co"><span class="r-pr">#></span> 98: 92.9728 -6.3534 -2.0868 -4.2155 -0.9444 0.1069 9.9615 7.1788 0.8736 3.1913 0.1998 0.2114 5.6533 1.4322</span> +<span class="r-out co"><span class="r-pr">#></span> 99: 93.4116 -6.1712 -2.0837 -4.2280 -0.9473 0.1197 9.4634 6.8198 0.8959 3.1806 0.1899 0.2167 5.9149 1.3768</span> +<span class="r-out co"><span class="r-pr">#></span> 100: 93.2598 -6.1345 -2.0645 -4.2237 -0.9575 0.1099 8.9903 6.4788 0.9204 3.2429 0.1903 0.2058 5.7085 1.4133</span> +<span class="r-out co"><span class="r-pr">#></span> 101: 93.3082 -6.1574 -2.0474 -4.2315 -0.9619 0.1161 9.0819 6.1549 0.8744 3.2049 0.1891 0.2278 5.6493 1.4894</span> +<span class="r-out co"><span class="r-pr">#></span> 102: 93.5741 -6.2923 -2.0484 -4.2853 -0.9665 0.1325 10.4108 5.8522 0.8804 3.5370 0.2024 0.2324 5.6995 1.4594</span> +<span class="r-out co"><span class="r-pr">#></span> 103: 92.9199 -6.1797 -2.0522 -4.2940 -0.9568 0.1289 9.8903 5.5596 0.8722 3.6682 0.1975 0.2398 5.5536 1.4510</span> +<span class="r-out co"><span class="r-pr">#></span> 104: 93.1139 -6.1630 -2.0546 -4.2912 -0.9613 0.1115 9.3958 5.2816 0.8648 3.6673 0.2010 0.2278 5.5768 1.4812</span> +<span class="r-out co"><span class="r-pr">#></span> 105: 93.4085 -6.0359 -2.0450 -4.2889 -0.9591 0.1258 8.9260 5.0175 0.8412 3.7286 0.1917 0.2171 5.6780 1.5203</span> +<span class="r-out co"><span class="r-pr">#></span> 106: 93.3103 -6.1029 -2.0425 -4.2948 -0.9579 0.0934 8.4797 4.7667 0.8539 3.6947 0.1947 0.2234 5.7210 1.4760</span> +<span class="r-out co"><span class="r-pr">#></span> 107: 93.6389 -5.9750 -2.0309 -4.2630 -0.9660 0.1110 8.0557 4.5283 0.8470 3.5100 0.2044 0.2299 5.6280 1.5525</span> +<span class="r-out co"><span class="r-pr">#></span> 108: 93.8641 -5.8551 -2.0360 -4.2311 -0.9629 0.0900 7.6529 4.3019 0.8567 3.3345 0.2014 0.2302 5.7841 1.5978</span> +<span class="r-out co"><span class="r-pr">#></span> 109: 93.6274 -6.0268 -2.0445 -4.3047 -0.9488 0.0979 7.2703 4.7807 0.8565 3.7665 0.1929 0.2271 5.7941 1.5580</span> +<span class="r-out co"><span class="r-pr">#></span> 110: 93.6320 -5.8321 -2.0413 -4.2855 -0.9477 0.1143 6.9068 4.5417 0.8412 3.6165 0.1901 0.2199 5.8169 1.5477</span> +<span class="r-out co"><span class="r-pr">#></span> 111: 93.6245 -5.8256 -2.0157 -4.2797 -0.9612 0.0940 6.5774 4.3146 0.8460 3.5782 0.1837 0.2182 5.6157 1.6424</span> +<span class="r-out co"><span class="r-pr">#></span> 112: 93.8512 -5.9045 -2.0116 -4.2409 -0.9708 0.0883 6.2486 4.0989 0.8658 3.5059 0.1761 0.2073 5.8852 1.6073</span> +<span class="r-out co"><span class="r-pr">#></span> 113: 93.7080 -5.9935 -2.0306 -4.1884 -0.9690 0.0740 5.9361 4.0088 0.9072 3.3400 0.1957 0.2169 6.3792 1.4770</span> +<span class="r-out co"><span class="r-pr">#></span> 114: 93.8574 -5.9185 -2.0233 -4.2030 -0.9588 0.1137 5.6393 3.8084 0.9322 3.2878 0.1939 0.2098 5.8891 1.5325</span> +<span class="r-out co"><span class="r-pr">#></span> 115: 93.7414 -5.8789 -2.0183 -4.2256 -0.9701 0.1105 5.6148 3.6180 0.9222 3.5507 0.1921 0.1993 5.6441 1.5458</span> +<span class="r-out co"><span class="r-pr">#></span> 116: 93.4104 -5.9704 -2.0428 -4.2091 -0.9807 0.1099 5.3341 4.1157 0.9363 3.4004 0.1968 0.2134 5.7764 1.4617</span> +<span class="r-out co"><span class="r-pr">#></span> 117: 93.5239 -5.9057 -2.0518 -4.2494 -0.9812 0.1127 6.8839 3.9099 0.9151 3.6604 0.1921 0.2095 5.4753 1.4249</span> +<span class="r-out co"><span class="r-pr">#></span> 118: 93.7599 -5.9418 -2.0482 -4.2272 -0.9822 0.1094 6.8133 3.7144 0.9198 3.5160 0.1971 0.2039 5.6467 1.4116</span> +<span class="r-out co"><span class="r-pr">#></span> 119: 93.6617 -6.0020 -2.0483 -4.2146 -0.9816 0.1003 6.4727 3.8251 0.9103 3.4716 0.1950 0.2109 5.8513 1.4268</span> +<span class="r-out co"><span class="r-pr">#></span> 120: 93.5436 -5.9804 -2.0458 -4.1906 -0.9819 0.1065 6.1490 3.6756 0.9088 3.2980 0.1989 0.2123 5.8268 1.4689</span> +<span class="r-out co"><span class="r-pr">#></span> 121: 93.4880 -5.9047 -2.0452 -4.1957 -0.9640 0.1349 5.8416 3.4918 0.8824 3.2437 0.1889 0.2017 5.7152 1.4382</span> +<span class="r-out co"><span class="r-pr">#></span> 122: 93.7406 -5.9844 -2.0596 -4.2328 -0.9558 0.1563 5.5495 3.7606 0.8489 3.3043 0.1795 0.2015 5.5095 1.5112</span> +<span class="r-out co"><span class="r-pr">#></span> 123: 93.6728 -6.0394 -2.0372 -4.2812 -0.9592 0.1507 5.2720 4.2004 0.8341 3.5274 0.1817 0.2008 5.6936 1.6011</span> +<span class="r-out co"><span class="r-pr">#></span> 124: 93.9591 -6.0483 -2.0280 -4.2613 -0.9594 0.1463 5.3846 4.1913 0.8351 3.4341 0.1870 0.2193 5.5694 1.5684</span> +<span class="r-out co"><span class="r-pr">#></span> 125: 94.0201 -5.9102 -2.0507 -4.2686 -0.9697 0.1455 5.1154 3.9818 0.8512 3.3475 0.1859 0.2165 5.6224 1.5643</span> +<span class="r-out co"><span class="r-pr">#></span> 126: 93.8825 -5.8970 -2.0543 -4.2569 -0.9663 0.1493 4.9144 3.7827 0.8907 3.3030 0.1876 0.2180 5.7351 1.4722</span> +<span class="r-out co"><span class="r-pr">#></span> 127: 93.9893 -5.8955 -2.0624 -4.2430 -0.9802 0.1476 7.2413 3.5935 0.8915 3.2740 0.1851 0.2110 5.7614 1.4305</span> +<span class="r-out co"><span class="r-pr">#></span> 128: 94.1849 -5.9123 -2.0624 -4.2385 -0.9786 0.1523 7.9575 3.4139 0.9094 3.2656 0.1807 0.2198 5.7366 1.4264</span> +<span class="r-out co"><span class="r-pr">#></span> 129: 94.0812 -6.0044 -2.0696 -4.3056 -0.9770 0.1693 8.7809 3.7526 0.9111 3.6172 0.1859 0.2255 5.8064 1.4718</span> +<span class="r-out co"><span class="r-pr">#></span> 130: 93.6046 -6.1387 -2.0718 -4.3056 -0.9821 0.1477 8.3419 4.3029 0.9177 3.6172 0.1867 0.2143 5.8893 1.4447</span> +<span class="r-out co"><span class="r-pr">#></span> 131: 93.5216 -6.1347 -2.0740 -4.3114 -0.9766 0.1288 8.2937 4.3407 0.9250 3.5298 0.1881 0.2293 5.8054 1.4219</span> +<span class="r-out co"><span class="r-pr">#></span> 132: 93.6142 -6.2789 -2.0786 -4.3297 -0.9716 0.1288 8.3731 5.1225 0.9236 3.6683 0.1929 0.2295 5.8064 1.4194</span> +<span class="r-out co"><span class="r-pr">#></span> 133: 93.4410 -5.9177 -2.0916 -4.3557 -0.9798 0.1066 7.9544 4.8663 0.9537 3.7076 0.1937 0.2279 5.9844 1.4297</span> +<span class="r-out co"><span class="r-pr">#></span> 134: 93.4716 -5.9152 -2.0838 -4.3611 -0.9818 0.1332 7.5567 4.6230 0.9161 3.7833 0.2017 0.2308 6.0611 1.5717</span> +<span class="r-out co"><span class="r-pr">#></span> 135: 93.3787 -6.0381 -2.0728 -4.2627 -0.9719 0.1051 7.2396 4.3919 0.8970 3.5941 0.1916 0.2193 5.8837 1.6057</span> +<span class="r-out co"><span class="r-pr">#></span> 136: 93.4339 -5.9876 -2.0801 -4.3002 -0.9690 0.1214 6.8776 4.1723 0.8888 3.4144 0.2002 0.2227 6.0141 1.5231</span> +<span class="r-out co"><span class="r-pr">#></span> 137: 93.7639 -6.0411 -2.0803 -4.2799 -0.9646 0.1484 6.5337 3.9765 0.8969 3.2437 0.1995 0.2115 5.9404 1.6402</span> +<span class="r-out co"><span class="r-pr">#></span> 138: 93.6414 -6.0122 -2.0714 -4.2666 -0.9755 0.1506 7.4057 3.7962 0.9242 3.1524 0.1934 0.2010 6.0666 1.5001</span> +<span class="r-out co"><span class="r-pr">#></span> 139: 93.7743 -5.7966 -2.0613 -4.2289 -0.9722 0.1383 7.9358 3.6064 0.9015 2.9948 0.1946 0.2029 5.9655 1.5250</span> +<span class="r-out co"><span class="r-pr">#></span> 140: 93.1082 -5.7994 -2.0388 -4.2289 -0.9659 0.1382 8.0282 3.4261 0.9053 2.9079 0.1909 0.2138 5.9183 1.5191</span> +<span class="r-out co"><span class="r-pr">#></span> 141: 93.2122 -6.0181 -2.0396 -4.2398 -0.9587 0.1016 8.9769 3.9426 0.9028 2.9136 0.1941 0.2195 6.1560 1.4902</span> +<span class="r-out co"><span class="r-pr">#></span> 142: 93.4684 -6.1438 -2.0273 -4.2541 -0.9508 0.0848 8.5281 4.8727 0.9056 2.9875 0.1901 0.2233 6.2546 1.4695</span> +<span class="r-out co"><span class="r-pr">#></span> 143: 93.0059 -6.0964 -2.0145 -4.2760 -0.9563 0.0826 8.1017 4.6291 0.9312 3.1063 0.1850 0.2138 6.5768 1.4391</span> +<span class="r-out co"><span class="r-pr">#></span> 144: 93.0612 -6.1127 -1.9951 -4.2589 -0.9539 0.0904 7.6966 4.6160 0.9623 3.1681 0.1824 0.2032 6.1506 1.4497</span> +<span class="r-out co"><span class="r-pr">#></span> 145: 93.5170 -6.1066 -1.9951 -4.3574 -0.9478 0.1040 7.3118 4.6263 0.9639 3.6914 0.1986 0.2292 5.9389 1.4867</span> +<span class="r-out co"><span class="r-pr">#></span> 146: 93.4915 -6.3235 -2.0006 -4.3866 -0.9579 0.1202 6.9462 6.0529 0.9514 3.9899 0.1887 0.2335 5.9265 1.4978</span> +<span class="r-out co"><span class="r-pr">#></span> 147: 93.8963 -6.1119 -2.0055 -4.3446 -0.9682 0.1242 7.1711 5.7503 0.9315 3.7904 0.1923 0.2332 5.9346 1.5021</span> +<span class="r-out co"><span class="r-pr">#></span> 148: 93.6758 -5.9705 -2.0137 -4.2906 -0.9614 0.1125 6.8125 5.4628 0.9506 3.6009 0.1913 0.2371 6.2579 1.4384</span> +<span class="r-out co"><span class="r-pr">#></span> 149: 93.6499 -6.0049 -2.0246 -4.2730 -0.9776 0.0996 6.4719 5.1896 0.9736 3.4209 0.1817 0.2252 6.3224 1.3878</span> +<span class="r-out co"><span class="r-pr">#></span> 150: 94.0242 -5.9760 -2.0176 -4.2182 -0.9773 0.1032 6.1483 4.9301 0.9944 3.2498 0.1807 0.2290 6.5662 1.3618</span> +<span class="r-out co"><span class="r-pr">#></span> 151: 93.9234 -5.8772 -2.0132 -4.2362 -0.9651 0.1058 7.2453 4.6836 0.9824 3.4860 0.1806 0.2175 6.2575 1.4370</span> +<span class="r-out co"><span class="r-pr">#></span> 152: 94.2513 -5.9391 -2.0814 -4.2278 -0.9753 0.1221 4.9753 3.4013 0.9808 3.3265 0.1836 0.1897 6.6966 1.3457</span> +<span class="r-out co"><span class="r-pr">#></span> 153: 93.9434 -6.1294 -2.0570 -4.2447 -0.9761 0.1527 5.0454 4.3115 0.9494 3.3663 0.1684 0.1680 5.9106 1.4777</span> +<span class="r-out co"><span class="r-pr">#></span> 154: 93.8141 -6.2749 -2.0366 -4.2383 -0.9835 0.1440 5.5466 5.3351 0.9320 3.3337 0.1731 0.1913 5.8842 1.4325</span> +<span class="r-out co"><span class="r-pr">#></span> 155: 94.1987 -6.1029 -2.0252 -4.2520 -0.9780 0.1132 7.1508 4.2713 0.9457 3.3428 0.1727 0.1691 6.1632 1.4658</span> +<span class="r-out co"><span class="r-pr">#></span> 156: 94.0626 -6.2640 -2.0263 -4.2461 -0.9854 0.1346 5.6296 5.1645 0.9423 3.3987 0.1697 0.1778 5.9631 1.4483</span> +<span class="r-out co"><span class="r-pr">#></span> 157: 93.9319 -6.1392 -2.0388 -4.2294 -0.9921 0.1265 5.6768 4.7366 0.9210 3.3673 0.1733 0.1789 5.9114 1.4976</span> +<span class="r-out co"><span class="r-pr">#></span> 158: 93.9123 -6.1970 -2.0165 -4.2241 -0.9924 0.1540 7.2552 4.7537 0.9369 3.2727 0.1805 0.1923 5.9324 1.5351</span> +<span class="r-out co"><span class="r-pr">#></span> 159: 93.9704 -6.4018 -2.0455 -4.2127 -0.9919 0.1413 7.7561 6.0732 0.9802 3.3376 0.1806 0.2260 6.4511 1.4227</span> +<span class="r-out co"><span class="r-pr">#></span> 160: 94.1967 -6.2985 -2.0412 -4.2264 -0.9795 0.1206 8.3836 6.1319 0.9689 3.4685 0.1792 0.2150 6.5116 1.4706</span> +<span class="r-out co"><span class="r-pr">#></span> 161: 94.3500 -6.1427 -2.0189 -4.2242 -1.0022 0.0837 8.0282 4.5505 0.9524 3.3269 0.1859 0.1816 6.0642 1.4746</span> +<span class="r-out co"><span class="r-pr">#></span> 162: 94.2711 -5.9578 -2.0215 -4.2078 -1.0110 0.0946 7.8634 3.3072 0.9559 3.2374 0.1876 0.1791 6.0798 1.4903</span> +<span class="r-out co"><span class="r-pr">#></span> 163: 93.9824 -5.8794 -2.0409 -4.2367 -0.9970 0.1150 9.3872 3.0498 0.9830 3.3179 0.1880 0.1828 5.8091 1.4852</span> +<span class="r-out co"><span class="r-pr">#></span> 164: 94.2013 -5.8651 -2.0122 -4.2257 -0.9906 0.1267 7.1953 3.0510 0.9697 3.2713 0.1871 0.1832 5.8741 1.5313</span> +<span class="r-out co"><span class="r-pr">#></span> 165: 94.1804 -5.7868 -2.0200 -4.2053 -0.9812 0.1219 6.7375 2.4769 0.9688 3.2706 0.1910 0.1859 5.7890 1.5188</span> +<span class="r-out co"><span class="r-pr">#></span> 166: 93.9790 -5.8156 -2.0311 -4.2438 -0.9784 0.1247 5.7617 2.6907 0.9533 3.5342 0.1953 0.1872 5.8816 1.5243</span> +<span class="r-out co"><span class="r-pr">#></span> 167: 93.2524 -5.8603 -2.0497 -4.2594 -0.9787 0.1265 4.7086 2.9121 0.9117 3.4696 0.1943 0.1832 5.9672 1.4567</span> +<span class="r-out co"><span class="r-pr">#></span> 168: 93.2924 -6.0371 -2.0528 -4.2607 -0.9727 0.1201 5.5273 4.0286 0.9177 3.4501 0.1918 0.1908 5.7790 1.4701</span> +<span class="r-out co"><span class="r-pr">#></span> 169: 93.4838 -6.1497 -2.0389 -4.2716 -0.9639 0.1127 5.4524 4.2700 0.9544 3.4329 0.1940 0.1871 5.7795 1.4575</span> +<span class="r-out co"><span class="r-pr">#></span> 170: 93.3951 -6.2298 -2.0438 -4.4133 -0.9939 0.1088 6.1460 4.6552 0.9645 4.5240 0.1978 0.2091 5.7549 1.5233</span> +<span class="r-out co"><span class="r-pr">#></span> 171: 93.4113 -6.1187 -2.0536 -4.4019 -0.9771 0.0899 6.8123 4.0073 0.9531 4.4290 0.1878 0.1970 5.9067 1.4857</span> +<span class="r-out co"><span class="r-pr">#></span> 172: 93.1140 -5.9515 -2.0530 -4.3250 -0.9723 0.1094 5.1247 3.4502 0.9572 3.8504 0.1954 0.1944 5.8583 1.4867</span> +<span class="r-out co"><span class="r-pr">#></span> 173: 92.9782 -6.0415 -2.0633 -4.2887 -0.9608 0.1081 4.1020 3.8967 0.9478 3.7222 0.1890 0.1812 5.9473 1.4583</span> +<span class="r-out co"><span class="r-pr">#></span> 174: 92.9661 -5.9295 -2.0457 -4.2907 -0.9626 0.0991 5.7954 3.3581 0.9785 3.7311 0.1867 0.2026 5.8087 1.4797</span> +<span class="r-out co"><span class="r-pr">#></span> 175: 93.2577 -5.8895 -2.0281 -4.2845 -0.9560 0.0829 7.3434 3.1501 0.9975 3.6334 0.1920 0.2151 5.4717 1.4832</span> +<span class="r-out co"><span class="r-pr">#></span> 176: 93.1210 -5.9567 -2.0370 -4.2848 -0.9488 0.0787 6.8946 3.4999 0.9983 3.6159 0.1922 0.2233 5.8426 1.4096</span> +<span class="r-out co"><span class="r-pr">#></span> 177: 92.5456 -6.1797 -2.0319 -4.2684 -0.9401 0.0873 6.9744 5.2939 0.9928 3.4880 0.1989 0.2213 5.9613 1.4367</span> +<span class="r-out co"><span class="r-pr">#></span> 178: 92.6854 -6.1483 -2.0278 -4.2705 -0.9504 0.0630 5.0582 5.0622 0.9953 3.4915 0.1930 0.2238 5.9775 1.4263</span> +<span class="r-out co"><span class="r-pr">#></span> 179: 93.1323 -6.1739 -2.0353 -4.2590 -0.9455 0.0584 4.9914 4.7898 0.9817 3.4163 0.1899 0.2124 5.9579 1.4242</span> +<span class="r-out co"><span class="r-pr">#></span> 180: 93.0611 -6.2228 -2.0441 -4.2977 -0.9387 0.0320 4.0323 5.5685 0.9890 3.7202 0.1940 0.2335 6.2224 1.4194</span> +<span class="r-out co"><span class="r-pr">#></span> 181: 92.7741 -6.1462 -2.0477 -4.3335 -0.9454 0.1011 3.7007 5.1590 0.9807 3.8469 0.1939 0.2463 5.9703 1.4343</span> +<span class="r-out co"><span class="r-pr">#></span> 182: 93.0775 -6.0640 -2.0496 -4.3171 -0.9444 0.0897 5.0266 4.5597 0.9792 3.7741 0.1931 0.2186 5.6727 1.4858</span> +<span class="r-out co"><span class="r-pr">#></span> 183: 93.2566 -6.1757 -2.0368 -4.2888 -0.9560 0.0809 5.8284 5.2504 0.9636 3.7078 0.1939 0.2262 5.5170 1.4560</span> +<span class="r-out co"><span class="r-pr">#></span> 184: 93.0357 -6.1158 -2.0217 -4.3111 -0.9453 0.0901 6.7209 5.4048 0.9503 3.8949 0.1967 0.2209 5.3578 1.4704</span> +<span class="r-out co"><span class="r-pr">#></span> 185: 93.0173 -6.1998 -2.0371 -4.3713 -0.9451 0.0752 6.1040 5.8272 0.9333 4.4038 0.1951 0.2238 5.5896 1.4202</span> +<span class="r-out co"><span class="r-pr">#></span> 186: 93.2835 -6.1217 -2.0383 -4.3308 -0.9574 0.1110 6.0519 4.7669 0.9400 4.0265 0.1972 0.2274 5.4560 1.4602</span> +<span class="r-out co"><span class="r-pr">#></span> 187: 93.5312 -6.3356 -2.0253 -4.3418 -0.9583 0.1166 6.7561 5.8784 0.9346 4.0264 0.2038 0.2281 5.5024 1.4994</span> +<span class="r-out co"><span class="r-pr">#></span> 188: 93.6460 -5.8426 -2.0237 -4.4519 -0.9594 0.1283 6.3492 3.4189 0.9091 4.9358 0.2086 0.2348 5.4301 1.5893</span> +<span class="r-out co"><span class="r-pr">#></span> 189: 93.8538 -6.0183 -2.0178 -4.3911 -0.9797 0.1262 8.7939 3.7358 0.9008 4.4894 0.2125 0.2199 5.6613 1.5073</span> +<span class="r-out co"><span class="r-pr">#></span> 190: 93.1543 -6.1364 -2.0451 -4.4389 -0.9708 0.1584 9.9803 4.2747 0.8922 4.8507 0.2084 0.2607 5.9136 1.4572</span> +<span class="r-out co"><span class="r-pr">#></span> 191: 93.4334 -6.1466 -2.0389 -4.4661 -0.9678 0.1565 7.8390 4.4393 0.9022 4.7857 0.2105 0.2634 5.7161 1.5325</span> +<span class="r-out co"><span class="r-pr">#></span> 192: 93.3623 -6.0940 -2.0240 -4.4569 -0.9673 0.1420 8.0856 4.3185 0.8895 4.4721 0.2113 0.2350 5.5282 1.5221</span> +<span class="r-out co"><span class="r-pr">#></span> 193: 93.1990 -5.9864 -2.0301 -4.4538 -0.9563 0.1515 8.4425 3.7598 0.8814 4.4376 0.2013 0.2257 5.4205 1.4820</span> +<span class="r-out co"><span class="r-pr">#></span> 194: 93.3165 -6.0045 -2.0353 -4.4314 -0.9525 0.1486 8.2370 3.6742 0.8947 4.4594 0.1960 0.2248 5.4579 1.4767</span> +<span class="r-out co"><span class="r-pr">#></span> 195: 93.1288 -6.1006 -2.0551 -4.5184 -0.9503 0.1583 9.6259 4.2294 0.9040 5.1981 0.1950 0.1962 5.5602 1.4254</span> +<span class="r-out co"><span class="r-pr">#></span> 196: 93.1943 -5.9871 -2.0607 -4.4728 -0.9446 0.1482 9.3401 3.5579 0.8925 4.7901 0.1892 0.1879 5.7296 1.4172</span> +<span class="r-out co"><span class="r-pr">#></span> 197: 93.5803 -5.9131 -2.0522 -4.3675 -0.9476 0.1571 7.2599 3.4241 0.8857 3.8551 0.1886 0.1793 5.4832 1.6006</span> +<span class="r-out co"><span class="r-pr">#></span> 198: 93.5703 -5.9980 -2.0550 -4.3578 -0.9519 0.1491 7.0416 3.8805 0.8563 3.7930 0.1882 0.1896 5.4355 1.5402</span> +<span class="r-out co"><span class="r-pr">#></span> 199: 93.2909 -5.8288 -2.0532 -4.3605 -0.9518 0.1692 8.3926 3.0173 0.8566 3.8610 0.1902 0.2033 5.5735 1.5647</span> +<span class="r-out co"><span class="r-pr">#></span> 200: 93.4049 -5.7474 -2.0447 -4.3548 -0.9517 0.1812 7.4977 2.8256 0.8520 3.8236 0.1897 0.2060 5.5092 1.5699</span> +<span class="r-out co"><span class="r-pr">#></span> 201: 93.3386 -5.8209 -2.0398 -4.4174 -0.9597 0.1738 6.3555 3.0871 0.8431 4.3211 0.1853 0.2062 5.5460 1.5925</span> +<span class="r-out co"><span class="r-pr">#></span> 202: 93.3397 -5.8313 -2.0387 -4.4364 -0.9580 0.1669 6.0946 3.1018 0.8460 4.5093 0.1821 0.2068 5.6622 1.5740</span> +<span class="r-out co"><span class="r-pr">#></span> 203: 93.3071 -5.8276 -2.0384 -4.4758 -0.9571 0.1639 5.7815 3.0575 0.8608 4.9441 0.1826 0.2052 5.6855 1.5570</span> +<span class="r-out co"><span class="r-pr">#></span> 204: 93.3138 -5.8477 -2.0368 -4.4714 -0.9541 0.1658 5.7526 3.1322 0.8704 4.9129 0.1816 0.2057 5.6642 1.5606</span> +<span class="r-out co"><span class="r-pr">#></span> 205: 93.3066 -5.8537 -2.0395 -4.4842 -0.9521 0.1642 5.6045 3.1633 0.8748 5.0053 0.1805 0.2036 5.6633 1.5550</span> +<span class="r-out co"><span class="r-pr">#></span> 206: 93.3042 -5.8790 -2.0453 -4.4977 -0.9501 0.1633 5.7219 3.3320 0.8807 5.1121 0.1793 0.1999 5.6888 1.5413</span> +<span class="r-out co"><span class="r-pr">#></span> 207: 93.3281 -5.9005 -2.0504 -4.5109 -0.9480 0.1629 5.8004 3.4696 0.8865 5.2248 0.1789 0.1961 5.7206 1.5357</span> +<span class="r-out co"><span class="r-pr">#></span> 208: 93.3437 -5.8972 -2.0569 -4.5200 -0.9452 0.1641 5.7523 3.4604 0.8875 5.2848 0.1787 0.1933 5.7450 1.5288</span> +<span class="r-out co"><span class="r-pr">#></span> 209: 93.3265 -5.8864 -2.0628 -4.5092 -0.9440 0.1639 5.5355 3.4138 0.8882 5.1586 0.1791 0.1916 5.7744 1.5283</span> +<span class="r-out co"><span class="r-pr">#></span> 210: 93.3087 -5.8812 -2.0671 -4.5004 -0.9426 0.1677 5.3488 3.3975 0.8895 5.0589 0.1798 0.1924 5.7781 1.5307</span> +<span class="r-out co"><span class="r-pr">#></span> 211: 93.2807 -5.8760 -2.0703 -4.5009 -0.9413 0.1709 5.2654 3.3770 0.8894 5.0377 0.1805 0.1927 5.7808 1.5282</span> +<span class="r-out co"><span class="r-pr">#></span> 212: 93.2815 -5.8637 -2.0711 -4.4955 -0.9409 0.1708 5.3028 3.3250 0.8914 4.9702 0.1819 0.1941 5.7827 1.5274</span> +<span class="r-out co"><span class="r-pr">#></span> 213: 93.2828 -5.8481 -2.0709 -4.4895 -0.9396 0.1702 5.3840 3.2614 0.8913 4.9108 0.1826 0.1953 5.7744 1.5301</span> +<span class="r-out co"><span class="r-pr">#></span> 214: 93.2645 -5.8422 -2.0704 -4.4882 -0.9384 0.1710 5.3939 3.2358 0.8931 4.8944 0.1828 0.1955 5.7797 1.5351</span> +<span class="r-out co"><span class="r-pr">#></span> 215: 93.2591 -5.8519 -2.0709 -4.4858 -0.9380 0.1713 5.5142 3.2959 0.8953 4.8587 0.1822 0.1960 5.7853 1.5369</span> +<span class="r-out co"><span class="r-pr">#></span> 216: 93.2595 -5.8523 -2.0715 -4.4827 -0.9376 0.1723 5.5563 3.3077 0.8964 4.8306 0.1817 0.1973 5.7975 1.5396</span> +<span class="r-out co"><span class="r-pr">#></span> 217: 93.2503 -5.8512 -2.0732 -4.4737 -0.9373 0.1734 5.5036 3.3182 0.8959 4.7582 0.1817 0.1992 5.7940 1.5365</span> +<span class="r-out co"><span class="r-pr">#></span> 218: 93.2345 -5.8463 -2.0749 -4.4639 -0.9372 0.1747 5.5046 3.2959 0.8959 4.6771 0.1817 0.2008 5.7889 1.5340</span> +<span class="r-out co"><span class="r-pr">#></span> 219: 93.2264 -5.8439 -2.0757 -4.4549 -0.9364 0.1759 5.4970 3.2802 0.8966 4.6015 0.1819 0.2027 5.7804 1.5321</span> +<span class="r-out co"><span class="r-pr">#></span> 220: 93.2259 -5.8464 -2.0758 -4.4493 -0.9363 0.1771 5.4793 3.2944 0.8950 4.5498 0.1823 0.2049 5.7745 1.5344</span> +<span class="r-out co"><span class="r-pr">#></span> 221: 93.2243 -5.8505 -2.0768 -4.4443 -0.9367 0.1785 5.5360 3.3132 0.8924 4.5028 0.1829 0.2068 5.7556 1.5329</span> +<span class="r-out co"><span class="r-pr">#></span> 222: 93.2385 -5.8603 -2.0776 -4.4371 -0.9376 0.1800 5.5401 3.3878 0.8903 4.4416 0.1834 0.2096 5.7522 1.5317</span> +<span class="r-out co"><span class="r-pr">#></span> 223: 93.2339 -5.8634 -2.0780 -4.4309 -0.9377 0.1803 5.5522 3.4132 0.8882 4.3844 0.1838 0.2118 5.7457 1.5323</span> +<span class="r-out co"><span class="r-pr">#></span> 224: 93.2379 -5.8686 -2.0778 -4.4262 -0.9374 0.1803 5.5469 3.4421 0.8848 4.3375 0.1842 0.2137 5.7429 1.5323</span> +<span class="r-out co"><span class="r-pr">#></span> 225: 93.2329 -5.8654 -2.0784 -4.4222 -0.9373 0.1811 5.5553 3.4255 0.8843 4.2952 0.1848 0.2160 5.7452 1.5295</span> +<span class="r-out co"><span class="r-pr">#></span> 226: 93.2330 -5.8621 -2.0789 -4.4182 -0.9366 0.1816 5.5838 3.4123 0.8838 4.2565 0.1858 0.2176 5.7453 1.5284</span> +<span class="r-out co"><span class="r-pr">#></span> 227: 93.2309 -5.8549 -2.0794 -4.4153 -0.9365 0.1823 5.6720 3.3787 0.8827 4.2227 0.1866 0.2181 5.7339 1.5287</span> +<span class="r-out co"><span class="r-pr">#></span> 228: 93.2248 -5.8556 -2.0794 -4.4116 -0.9372 0.1832 5.7344 3.3780 0.8830 4.1863 0.1873 0.2200 5.7232 1.5308</span> +<span class="r-out co"><span class="r-pr">#></span> 229: 93.2215 -5.8615 -2.0798 -4.4081 -0.9373 0.1844 5.8478 3.4087 0.8821 4.1558 0.1878 0.2217 5.7174 1.5283</span> +<span class="r-out co"><span class="r-pr">#></span> 230: 93.2122 -5.8646 -2.0807 -4.4053 -0.9372 0.1858 5.8987 3.4233 0.8800 4.1288 0.1881 0.2233 5.7073 1.5272</span> +<span class="r-out co"><span class="r-pr">#></span> 231: 93.2080 -5.8665 -2.0816 -4.4025 -0.9372 0.1872 5.9544 3.4381 0.8782 4.1008 0.1883 0.2250 5.7006 1.5283</span> +<span class="r-out co"><span class="r-pr">#></span> 232: 93.1921 -5.8677 -2.0829 -4.3997 -0.9370 0.1887 5.9768 3.4440 0.8770 4.0748 0.1883 0.2268 5.7012 1.5261</span> +<span class="r-out co"><span class="r-pr">#></span> 233: 93.1794 -5.8674 -2.0840 -4.3972 -0.9363 0.1892 6.0074 3.4397 0.8757 4.0495 0.1884 0.2281 5.6997 1.5235</span> +<span class="r-out co"><span class="r-pr">#></span> 234: 93.1623 -5.8677 -2.0853 -4.3959 -0.9358 0.1898 5.9759 3.4442 0.8750 4.0330 0.1887 0.2295 5.7000 1.5223</span> +<span class="r-out co"><span class="r-pr">#></span> 235: 93.1499 -5.8709 -2.0862 -4.3918 -0.9356 0.1900 5.9951 3.4709 0.8747 4.0020 0.1891 0.2309 5.7002 1.5219</span> +<span class="r-out co"><span class="r-pr">#></span> 236: 93.1408 -5.8764 -2.0875 -4.3879 -0.9349 0.1898 6.0359 3.5027 0.8752 3.9720 0.1895 0.2321 5.7098 1.5196</span> +<span class="r-out co"><span class="r-pr">#></span> 237: 93.1307 -5.8766 -2.0887 -4.3843 -0.9344 0.1896 6.0589 3.5108 0.8755 3.9437 0.1900 0.2330 5.7176 1.5174</span> +<span class="r-out co"><span class="r-pr">#></span> 238: 93.1233 -5.8767 -2.0889 -4.3806 -0.9341 0.1891 6.0959 3.5158 0.8745 3.9173 0.1907 0.2339 5.7198 1.5169</span> +<span class="r-out co"><span class="r-pr">#></span> 239: 93.1245 -5.8810 -2.0889 -4.3775 -0.9337 0.1885 6.1196 3.5614 0.8746 3.8935 0.1915 0.2349 5.7177 1.5172</span> +<span class="r-out co"><span class="r-pr">#></span> 240: 93.1180 -5.8836 -2.0893 -4.3745 -0.9332 0.1883 6.1647 3.6004 0.8741 3.8709 0.1921 0.2360 5.7150 1.5192</span> +<span class="r-out co"><span class="r-pr">#></span> 241: 93.1096 -5.8838 -2.0898 -4.3714 -0.9327 0.1883 6.2283 3.6196 0.8743 3.8487 0.1927 0.2366 5.7177 1.5202</span> +<span class="r-out co"><span class="r-pr">#></span> 242: 93.1058 -5.8804 -2.0912 -4.3684 -0.9320 0.1888 6.2553 3.6018 0.8723 3.8274 0.1933 0.2378 5.7265 1.5198</span> +<span class="r-out co"><span class="r-pr">#></span> 243: 93.0953 -5.8762 -2.0924 -4.3668 -0.9315 0.1892 6.2692 3.5785 0.8705 3.8130 0.1940 0.2391 5.7353 1.5205</span> +<span class="r-out co"><span class="r-pr">#></span> 244: 93.0840 -5.8758 -2.0928 -4.3658 -0.9310 0.1889 6.2702 3.5746 0.8695 3.8007 0.1947 0.2401 5.7382 1.5205</span> +<span class="r-out co"><span class="r-pr">#></span> 245: 93.0720 -5.8795 -2.0933 -4.3647 -0.9306 0.1895 6.3022 3.5971 0.8685 3.7886 0.1953 0.2407 5.7367 1.5192</span> +<span class="r-out co"><span class="r-pr">#></span> 246: 93.0626 -5.8798 -2.0933 -4.3637 -0.9301 0.1898 6.2987 3.5992 0.8680 3.7781 0.1957 0.2410 5.7331 1.5184</span> +<span class="r-out co"><span class="r-pr">#></span> 247: 93.0526 -5.8805 -2.0934 -4.3610 -0.9298 0.1903 6.3067 3.6060 0.8682 3.7618 0.1963 0.2414 5.7329 1.5189</span> +<span class="r-out co"><span class="r-pr">#></span> 248: 93.0481 -5.8780 -2.0933 -4.3583 -0.9296 0.1911 6.3135 3.6007 0.8683 3.7460 0.1967 0.2420 5.7344 1.5191</span> +<span class="r-out co"><span class="r-pr">#></span> 249: 93.0483 -5.8762 -2.0933 -4.3558 -0.9294 0.1913 6.3095 3.5961 0.8685 3.7298 0.1970 0.2422 5.7414 1.5179</span> +<span class="r-out co"><span class="r-pr">#></span> 250: 93.0520 -5.8768 -2.0931 -4.3538 -0.9292 0.1912 6.2900 3.6003 0.8692 3.7176 0.1973 0.2424 5.7547 1.5148</span> +<span class="r-out co"><span class="r-pr">#></span> 251: 93.0430 -5.8769 -2.0930 -4.3516 -0.9291 0.1905 6.2815 3.6041 0.8704 3.7045 0.1975 0.2427 5.7653 1.5123</span> +<span class="r-out co"><span class="r-pr">#></span> 252: 93.0300 -5.8743 -2.0928 -4.3490 -0.9291 0.1901 6.2896 3.5885 0.8716 3.6919 0.1978 0.2428 5.7797 1.5106</span> +<span class="r-out co"><span class="r-pr">#></span> 253: 93.0217 -5.8740 -2.0926 -4.3468 -0.9289 0.1898 6.3238 3.5875 0.8731 3.6817 0.1981 0.2429 5.7885 1.5102</span> +<span class="r-out co"><span class="r-pr">#></span> 254: 93.0147 -5.8729 -2.0924 -4.3439 -0.9289 0.1892 6.3418 3.5857 0.8732 3.6683 0.1980 0.2426 5.7912 1.5102</span> +<span class="r-out co"><span class="r-pr">#></span> 255: 93.0144 -5.8743 -2.0922 -4.3407 -0.9290 0.1885 6.3755 3.5933 0.8735 3.6580 0.1979 0.2420 5.7932 1.5086</span> +<span class="r-out co"><span class="r-pr">#></span> 256: 93.0136 -5.8778 -2.0919 -4.3376 -0.9290 0.1876 6.3932 3.6240 0.8741 3.6481 0.1980 0.2418 5.7969 1.5066</span> +<span class="r-out co"><span class="r-pr">#></span> 257: 93.0116 -5.8792 -2.0917 -4.3345 -0.9291 0.1862 6.4096 3.6459 0.8744 3.6385 0.1980 0.2414 5.7990 1.5065</span> +<span class="r-out co"><span class="r-pr">#></span> 258: 93.0084 -5.8812 -2.0913 -4.3319 -0.9290 0.1842 6.4231 3.6686 0.8753 3.6281 0.1980 0.2414 5.8024 1.5050</span> +<span class="r-out co"><span class="r-pr">#></span> 259: 93.0090 -5.8866 -2.0909 -4.3293 -0.9287 0.1825 6.4361 3.7063 0.8762 3.6181 0.1981 0.2413 5.8106 1.5030</span> +<span class="r-out co"><span class="r-pr">#></span> 260: 93.0067 -5.8911 -2.0902 -4.3265 -0.9283 0.1811 6.4128 3.7384 0.8765 3.6076 0.1981 0.2412 5.8102 1.5026</span> +<span class="r-out co"><span class="r-pr">#></span> 261: 93.0060 -5.8933 -2.0894 -4.3237 -0.9284 0.1799 6.4253 3.7604 0.8765 3.5968 0.1981 0.2410 5.8080 1.5026</span> +<span class="r-out co"><span class="r-pr">#></span> 262: 93.0051 -5.8934 -2.0884 -4.3208 -0.9285 0.1789 6.4008 3.7597 0.8762 3.5855 0.1981 0.2412 5.8046 1.5020</span> +<span class="r-out co"><span class="r-pr">#></span> 263: 93.0019 -5.8945 -2.0875 -4.3182 -0.9287 0.1781 6.3788 3.7644 0.8758 3.5756 0.1982 0.2411 5.8048 1.5023</span> +<span class="r-out co"><span class="r-pr">#></span> 264: 93.0021 -5.8959 -2.0870 -4.3158 -0.9293 0.1773 6.3614 3.7682 0.8749 3.5667 0.1983 0.2410 5.8017 1.5021</span> +<span class="r-out co"><span class="r-pr">#></span> 265: 93.0053 -5.8989 -2.0866 -4.3130 -0.9296 0.1766 6.3506 3.7814 0.8739 3.5567 0.1982 0.2409 5.7995 1.5018</span> +<span class="r-out co"><span class="r-pr">#></span> 266: 93.0061 -5.8992 -2.0864 -4.3104 -0.9300 0.1757 6.3307 3.7730 0.8733 3.5471 0.1982 0.2408 5.7994 1.5012</span> +<span class="r-out co"><span class="r-pr">#></span> 267: 93.0098 -5.9009 -2.0861 -4.3077 -0.9302 0.1749 6.3326 3.7738 0.8730 3.5388 0.1983 0.2407 5.7964 1.5004</span> +<span class="r-out co"><span class="r-pr">#></span> 268: 93.0144 -5.9000 -2.0853 -4.3054 -0.9304 0.1740 6.3487 3.7623 0.8729 3.5290 0.1985 0.2405 5.7897 1.5014</span> +<span class="r-out co"><span class="r-pr">#></span> 269: 93.0146 -5.8984 -2.0847 -4.3032 -0.9306 0.1731 6.3716 3.7485 0.8735 3.5197 0.1985 0.2402 5.7867 1.5016</span> +<span class="r-out co"><span class="r-pr">#></span> 270: 93.0159 -5.8950 -2.0842 -4.3013 -0.9307 0.1722 6.3630 3.7266 0.8743 3.5098 0.1986 0.2400 5.7837 1.5016</span> +<span class="r-out co"><span class="r-pr">#></span> 271: 93.0161 -5.8925 -2.0837 -4.2995 -0.9309 0.1715 6.3539 3.7068 0.8744 3.5001 0.1986 0.2400 5.7843 1.5020</span> +<span class="r-out co"><span class="r-pr">#></span> 272: 93.0195 -5.8919 -2.0837 -4.2977 -0.9314 0.1710 6.3430 3.6964 0.8744 3.4922 0.1985 0.2400 5.7859 1.5031</span> +<span class="r-out co"><span class="r-pr">#></span> 273: 93.0184 -5.8923 -2.0837 -4.2961 -0.9318 0.1705 6.3531 3.6914 0.8743 3.4854 0.1984 0.2402 5.7880 1.5030</span> +<span class="r-out co"><span class="r-pr">#></span> 274: 93.0178 -5.8927 -2.0834 -4.2951 -0.9320 0.1701 6.3818 3.6865 0.8749 3.4824 0.1984 0.2403 5.7928 1.5020</span> +<span class="r-out co"><span class="r-pr">#></span> 275: 93.0204 -5.8937 -2.0833 -4.2942 -0.9324 0.1700 6.3961 3.6842 0.8754 3.4790 0.1984 0.2402 5.7949 1.5011</span> +<span class="r-out co"><span class="r-pr">#></span> 276: 93.0228 -5.8958 -2.0833 -4.2932 -0.9327 0.1699 6.3965 3.6870 0.8760 3.4752 0.1984 0.2402 5.7934 1.5002</span> +<span class="r-out co"><span class="r-pr">#></span> 277: 93.0251 -5.9000 -2.0833 -4.2921 -0.9329 0.1695 6.4076 3.7032 0.8766 3.4712 0.1985 0.2400 5.7979 1.4989</span> +<span class="r-out co"><span class="r-pr">#></span> 278: 93.0297 -5.9021 -2.0833 -4.2912 -0.9331 0.1690 6.4279 3.7073 0.8771 3.4671 0.1986 0.2399 5.7978 1.4981</span> +<span class="r-out co"><span class="r-pr">#></span> 279: 93.0273 -5.9021 -2.0832 -4.2902 -0.9332 0.1684 6.4349 3.7003 0.8779 3.4622 0.1988 0.2400 5.7993 1.4972</span> +<span class="r-out co"><span class="r-pr">#></span> 280: 93.0236 -5.9030 -2.0831 -4.2892 -0.9334 0.1674 6.4776 3.6986 0.8787 3.4576 0.1990 0.2401 5.8026 1.4963</span> +<span class="r-out co"><span class="r-pr">#></span> 281: 93.0172 -5.9037 -2.0829 -4.2881 -0.9337 0.1665 6.4942 3.6984 0.8797 3.4536 0.1992 0.2402 5.8056 1.4955</span> +<span class="r-out co"><span class="r-pr">#></span> 282: 93.0147 -5.9055 -2.0827 -4.2872 -0.9339 0.1656 6.4861 3.7031 0.8810 3.4492 0.1992 0.2403 5.8107 1.4954</span> +<span class="r-out co"><span class="r-pr">#></span> 283: 93.0138 -5.9053 -2.0824 -4.2865 -0.9341 0.1646 6.4962 3.6967 0.8822 3.4451 0.1993 0.2406 5.8142 1.4959</span> +<span class="r-out co"><span class="r-pr">#></span> 284: 93.0132 -5.9067 -2.0821 -4.2864 -0.9343 0.1636 6.5021 3.7013 0.8838 3.4437 0.1993 0.2406 5.8146 1.4955</span> +<span class="r-out co"><span class="r-pr">#></span> 285: 93.0138 -5.9081 -2.0819 -4.2859 -0.9343 0.1628 6.5037 3.7043 0.8851 3.4406 0.1994 0.2406 5.8146 1.4945</span> +<span class="r-out co"><span class="r-pr">#></span> 286: 93.0119 -5.9086 -2.0815 -4.2858 -0.9342 0.1620 6.5068 3.7037 0.8864 3.4395 0.1994 0.2404 5.8133 1.4936</span> +<span class="r-out co"><span class="r-pr">#></span> 287: 93.0122 -5.9089 -2.0813 -4.2860 -0.9342 0.1614 6.5202 3.7044 0.8872 3.4399 0.1997 0.2401 5.8096 1.4929</span> +<span class="r-out co"><span class="r-pr">#></span> 288: 93.0104 -5.9083 -2.0812 -4.2858 -0.9342 0.1609 6.5237 3.6997 0.8876 3.4376 0.1999 0.2398 5.8041 1.4924</span> +<span class="r-out co"><span class="r-pr">#></span> 289: 93.0076 -5.9066 -2.0812 -4.2854 -0.9342 0.1604 6.5121 3.6893 0.8881 3.4342 0.1999 0.2394 5.8021 1.4922</span> +<span class="r-out co"><span class="r-pr">#></span> 290: 93.0064 -5.9052 -2.0813 -4.2851 -0.9343 0.1602 6.5106 3.6772 0.8886 3.4309 0.2000 0.2389 5.7988 1.4915</span> +<span class="r-out co"><span class="r-pr">#></span> 291: 93.0071 -5.9031 -2.0813 -4.2849 -0.9345 0.1601 6.5031 3.6628 0.8891 3.4284 0.2000 0.2384 5.7959 1.4908</span> +<span class="r-out co"><span class="r-pr">#></span> 292: 93.0114 -5.9023 -2.0809 -4.2841 -0.9346 0.1594 6.4930 3.6538 0.8894 3.4237 0.2001 0.2383 5.7923 1.4902</span> +<span class="r-out co"><span class="r-pr">#></span> 293: 93.0148 -5.9032 -2.0807 -4.2834 -0.9348 0.1589 6.4836 3.6542 0.8898 3.4206 0.2002 0.2380 5.7893 1.4893</span> +<span class="r-out co"><span class="r-pr">#></span> 294: 93.0161 -5.9026 -2.0806 -4.2826 -0.9349 0.1582 6.4719 3.6469 0.8901 3.4176 0.2005 0.2375 5.7898 1.4886</span> +<span class="r-out co"><span class="r-pr">#></span> 295: 93.0212 -5.9008 -2.0806 -4.2817 -0.9350 0.1576 6.4649 3.6372 0.8904 3.4145 0.2007 0.2370 5.7885 1.4890</span> +<span class="r-out co"><span class="r-pr">#></span> 296: 93.0270 -5.8989 -2.0805 -4.2809 -0.9351 0.1569 6.4835 3.6279 0.8911 3.4124 0.2010 0.2366 5.7886 1.4884</span> +<span class="r-out co"><span class="r-pr">#></span> 297: 93.0291 -5.8969 -2.0803 -4.2800 -0.9352 0.1560 6.5014 3.6177 0.8915 3.4094 0.2012 0.2364 5.7873 1.4880</span> +<span class="r-out co"><span class="r-pr">#></span> 298: 93.0332 -5.8963 -2.0801 -4.2790 -0.9352 0.1551 6.5168 3.6111 0.8919 3.4065 0.2014 0.2361 5.7855 1.4875</span> +<span class="r-out co"><span class="r-pr">#></span> 299: 93.0339 -5.8961 -2.0799 -4.2782 -0.9352 0.1542 6.5288 3.6081 0.8927 3.4038 0.2015 0.2358 5.7844 1.4869</span> +<span class="r-out co"><span class="r-pr">#></span> 300: 93.0335 -5.8971 -2.0797 -4.2772 -0.9351 0.1533 6.5409 3.6097 0.8937 3.4009 0.2017 0.2356 5.7844 1.4859</span> +<span class="r-out co"><span class="r-pr">#></span> 301: 93.0320 -5.8979 -2.0796 -4.2762 -0.9350 0.1522 6.5553 3.6126 0.8945 3.3977 0.2020 0.2354 5.7898 1.4847</span> +<span class="r-out co"><span class="r-pr">#></span> 302: 93.0321 -5.8997 -2.0795 -4.2751 -0.9351 0.1513 6.5737 3.6195 0.8956 3.3943 0.2023 0.2351 5.7917 1.4835</span> +<span class="r-out co"><span class="r-pr">#></span> 303: 93.0328 -5.8984 -2.0792 -4.2739 -0.9351 0.1504 6.5888 3.6111 0.8964 3.3912 0.2025 0.2350 5.7915 1.4825</span> +<span class="r-out co"><span class="r-pr">#></span> 304: 93.0357 -5.8969 -2.0790 -4.2728 -0.9350 0.1494 6.5907 3.6018 0.8975 3.3882 0.2026 0.2348 5.7929 1.4813</span> +<span class="r-out co"><span class="r-pr">#></span> 305: 93.0351 -5.8953 -2.0786 -4.2718 -0.9349 0.1484 6.5764 3.5916 0.8986 3.3858 0.2027 0.2345 5.7937 1.4816</span> +<span class="r-out co"><span class="r-pr">#></span> 306: 93.0352 -5.8950 -2.0784 -4.2707 -0.9350 0.1475 6.5727 3.5890 0.8999 3.3835 0.2028 0.2341 5.7981 1.4810</span> +<span class="r-out co"><span class="r-pr">#></span> 307: 93.0354 -5.8947 -2.0784 -4.2699 -0.9351 0.1466 6.5759 3.5853 0.9010 3.3820 0.2030 0.2339 5.8028 1.4799</span> +<span class="r-out co"><span class="r-pr">#></span> 308: 93.0336 -5.8938 -2.0783 -4.2690 -0.9351 0.1459 6.5855 3.5776 0.9022 3.3809 0.2031 0.2333 5.8014 1.4788</span> +<span class="r-out co"><span class="r-pr">#></span> 309: 93.0311 -5.8931 -2.0780 -4.2683 -0.9351 0.1452 6.5799 3.5717 0.9038 3.3805 0.2033 0.2328 5.8048 1.4779</span> +<span class="r-out co"><span class="r-pr">#></span> 310: 93.0303 -5.8915 -2.0778 -4.2675 -0.9352 0.1447 6.5716 3.5609 0.9046 3.3797 0.2033 0.2323 5.8060 1.4774</span> +<span class="r-out co"><span class="r-pr">#></span> 311: 93.0275 -5.8915 -2.0776 -4.2668 -0.9352 0.1441 6.5679 3.5581 0.9052 3.3788 0.2034 0.2319 5.8056 1.4770</span> +<span class="r-out co"><span class="r-pr">#></span> 312: 93.0258 -5.8920 -2.0775 -4.2659 -0.9352 0.1435 6.5573 3.5571 0.9058 3.3775 0.2033 0.2314 5.8053 1.4766</span> +<span class="r-out co"><span class="r-pr">#></span> 313: 93.0234 -5.8928 -2.0773 -4.2649 -0.9353 0.1431 6.5510 3.5573 0.9065 3.3761 0.2033 0.2309 5.8046 1.4757</span> +<span class="r-out co"><span class="r-pr">#></span> 314: 93.0237 -5.8937 -2.0771 -4.2639 -0.9355 0.1425 6.5488 3.5578 0.9074 3.3747 0.2033 0.2303 5.8029 1.4751</span> +<span class="r-out co"><span class="r-pr">#></span> 315: 93.0237 -5.8940 -2.0769 -4.2629 -0.9357 0.1420 6.5480 3.5565 0.9081 3.3730 0.2034 0.2299 5.8010 1.4746</span> +<span class="r-out co"><span class="r-pr">#></span> 316: 93.0218 -5.8936 -2.0767 -4.2617 -0.9358 0.1413 6.5424 3.5517 0.9087 3.3705 0.2034 0.2296 5.7992 1.4741</span> +<span class="r-out co"><span class="r-pr">#></span> 317: 93.0218 -5.8932 -2.0766 -4.2606 -0.9359 0.1406 6.5576 3.5474 0.9091 3.3679 0.2034 0.2292 5.7965 1.4736</span> +<span class="r-out co"><span class="r-pr">#></span> 318: 93.0215 -5.8927 -2.0765 -4.2597 -0.9361 0.1402 6.5884 3.5420 0.9096 3.3661 0.2034 0.2288 5.7960 1.4727</span> +<span class="r-out co"><span class="r-pr">#></span> 319: 93.0201 -5.8938 -2.0764 -4.2588 -0.9361 0.1397 6.6095 3.5439 0.9101 3.3642 0.2034 0.2283 5.7943 1.4719</span> +<span class="r-out co"><span class="r-pr">#></span> 320: 93.0188 -5.8926 -2.0763 -4.2579 -0.9361 0.1392 6.6170 3.5368 0.9103 3.3622 0.2034 0.2282 5.7930 1.4711</span> +<span class="r-out co"><span class="r-pr">#></span> 321: 93.0155 -5.8908 -2.0762 -4.2569 -0.9361 0.1385 6.6328 3.5268 0.9105 3.3598 0.2033 0.2282 5.7921 1.4702</span> +<span class="r-out co"><span class="r-pr">#></span> 322: 93.0133 -5.8894 -2.0760 -4.2561 -0.9360 0.1378 6.6415 3.5192 0.9110 3.3580 0.2032 0.2282 5.7903 1.4698</span> +<span class="r-out co"><span class="r-pr">#></span> 323: 93.0089 -5.8888 -2.0759 -4.2555 -0.9360 0.1372 6.6480 3.5131 0.9107 3.3563 0.2031 0.2285 5.7915 1.4691</span> +<span class="r-out co"><span class="r-pr">#></span> 324: 93.0038 -5.8881 -2.0758 -4.2547 -0.9359 0.1364 6.6639 3.5076 0.9106 3.3547 0.2029 0.2287 5.7912 1.4687</span> +<span class="r-out co"><span class="r-pr">#></span> 325: 93.0011 -5.8871 -2.0756 -4.2540 -0.9359 0.1361 6.6587 3.5005 0.9102 3.3531 0.2028 0.2289 5.7896 1.4686</span> +<span class="r-out co"><span class="r-pr">#></span> 326: 93.0033 -5.8874 -2.0755 -4.2535 -0.9360 0.1360 6.6621 3.4995 0.9098 3.3510 0.2026 0.2294 5.7883 1.4686</span> +<span class="r-out co"><span class="r-pr">#></span> 327: 93.0039 -5.8885 -2.0754 -4.2532 -0.9361 0.1359 6.6589 3.5051 0.9093 3.3497 0.2025 0.2297 5.7869 1.4687</span> +<span class="r-out co"><span class="r-pr">#></span> 328: 93.0061 -5.8896 -2.0753 -4.2529 -0.9362 0.1355 6.6671 3.5132 0.9088 3.3484 0.2024 0.2299 5.7854 1.4687</span> +<span class="r-out co"><span class="r-pr">#></span> 329: 93.0077 -5.8915 -2.0755 -4.2525 -0.9363 0.1352 6.6719 3.5255 0.9085 3.3464 0.2024 0.2301 5.7850 1.4682</span> +<span class="r-out co"><span class="r-pr">#></span> 330: 93.0061 -5.8942 -2.0757 -4.2518 -0.9365 0.1351 6.6696 3.5399 0.9083 3.3438 0.2023 0.2302 5.7840 1.4680</span> +<span class="r-out co"><span class="r-pr">#></span> 331: 93.0032 -5.8953 -2.0759 -4.2513 -0.9366 0.1348 6.6554 3.5433 0.9080 3.3411 0.2022 0.2302 5.7839 1.4677</span> +<span class="r-out co"><span class="r-pr">#></span> 332: 93.0013 -5.8956 -2.0761 -4.2507 -0.9367 0.1347 6.6298 3.5423 0.9079 3.3385 0.2021 0.2302 5.7851 1.4672</span> +<span class="r-out co"><span class="r-pr">#></span> 333: 93.0026 -5.8950 -2.0764 -4.2502 -0.9368 0.1346 6.6207 3.5365 0.9078 3.3357 0.2021 0.2303 5.7849 1.4667</span> +<span class="r-out co"><span class="r-pr">#></span> 334: 93.0019 -5.8933 -2.0767 -4.2497 -0.9369 0.1348 6.6145 3.5259 0.9077 3.3330 0.2021 0.2302 5.7856 1.4662</span> +<span class="r-out co"><span class="r-pr">#></span> 335: 93.0038 -5.8930 -2.0768 -4.2492 -0.9370 0.1348 6.6200 3.5227 0.9078 3.3307 0.2020 0.2303 5.7845 1.4654</span> +<span class="r-out co"><span class="r-pr">#></span> 336: 93.0038 -5.8923 -2.0765 -4.2488 -0.9371 0.1348 6.6316 3.5180 0.9081 3.3291 0.2019 0.2304 5.7837 1.4654</span> +<span class="r-out co"><span class="r-pr">#></span> 337: 93.0074 -5.8927 -2.0764 -4.2485 -0.9373 0.1349 6.6509 3.5187 0.9083 3.3275 0.2018 0.2304 5.7808 1.4655</span> +<span class="r-out co"><span class="r-pr">#></span> 338: 93.0117 -5.8950 -2.0761 -4.2483 -0.9377 0.1349 6.6559 3.5291 0.9087 3.3263 0.2018 0.2303 5.7770 1.4657</span> +<span class="r-out co"><span class="r-pr">#></span> 339: 93.0172 -5.8960 -2.0759 -4.2482 -0.9380 0.1349 6.6610 3.5304 0.9090 3.3260 0.2017 0.2302 5.7744 1.4657</span> +<span class="r-out co"><span class="r-pr">#></span> 340: 93.0179 -5.8977 -2.0757 -4.2481 -0.9383 0.1349 6.6583 3.5340 0.9093 3.3263 0.2017 0.2301 5.7749 1.4650</span> +<span class="r-out co"><span class="r-pr">#></span> 341: 93.0201 -5.8986 -2.0755 -4.2484 -0.9386 0.1348 6.6603 3.5337 0.9092 3.3283 0.2018 0.2300 5.7738 1.4650</span> +<span class="r-out co"><span class="r-pr">#></span> 342: 93.0245 -5.8990 -2.0752 -4.2484 -0.9389 0.1348 6.6680 3.5324 0.9093 3.3297 0.2018 0.2300 5.7727 1.4649</span> +<span class="r-out co"><span class="r-pr">#></span> 343: 93.0302 -5.9006 -2.0751 -4.2484 -0.9391 0.1347 6.6715 3.5367 0.9093 3.3313 0.2017 0.2300 5.7729 1.4645</span> +<span class="r-out co"><span class="r-pr">#></span> 344: 93.0340 -5.9026 -2.0749 -4.2484 -0.9394 0.1346 6.6793 3.5438 0.9093 3.3326 0.2017 0.2301 5.7709 1.4646</span> +<span class="r-out co"><span class="r-pr">#></span> 345: 93.0372 -5.9049 -2.0746 -4.2484 -0.9397 0.1347 6.6874 3.5515 0.9090 3.3340 0.2017 0.2301 5.7688 1.4648</span> +<span class="r-out co"><span class="r-pr">#></span> 346: 93.0372 -5.9063 -2.0743 -4.2483 -0.9399 0.1348 6.6963 3.5592 0.9090 3.3348 0.2018 0.2299 5.7680 1.4656</span> +<span class="r-out co"><span class="r-pr">#></span> 347: 93.0383 -5.9075 -2.0742 -4.2481 -0.9402 0.1350 6.7101 3.5658 0.9093 3.3353 0.2018 0.2299 5.7672 1.4649</span> +<span class="r-out co"><span class="r-pr">#></span> 348: 93.0412 -5.9084 -2.0742 -4.2479 -0.9405 0.1351 6.7183 3.5707 0.9095 3.3356 0.2019 0.2297 5.7657 1.4645</span> +<span class="r-out co"><span class="r-pr">#></span> 349: 93.0436 -5.9097 -2.0742 -4.2477 -0.9407 0.1351 6.7143 3.5783 0.9098 3.3359 0.2019 0.2295 5.7646 1.4643</span> +<span class="r-out co"><span class="r-pr">#></span> 350: 93.0476 -5.9105 -2.0742 -4.2474 -0.9409 0.1351 6.7239 3.5808 0.9100 3.3354 0.2019 0.2294 5.7628 1.4639</span> +<span class="r-out co"><span class="r-pr">#></span> 351: 93.0506 -5.9113 -2.0741 -4.2473 -0.9411 0.1352 6.7270 3.5825 0.9103 3.3356 0.2019 0.2292 5.7604 1.4637</span> +<span class="r-out co"><span class="r-pr">#></span> 352: 93.0529 -5.9127 -2.0740 -4.2471 -0.9413 0.1353 6.7312 3.5886 0.9107 3.3358 0.2019 0.2290 5.7594 1.4634</span> +<span class="r-out co"><span class="r-pr">#></span> 353: 93.0580 -5.9139 -2.0739 -4.2470 -0.9415 0.1354 6.7315 3.5922 0.9111 3.3357 0.2019 0.2288 5.7571 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 354: 93.0639 -5.9129 -2.0738 -4.2468 -0.9417 0.1354 6.7390 3.5876 0.9112 3.3356 0.2018 0.2286 5.7541 1.4642</span> +<span class="r-out co"><span class="r-pr">#></span> 355: 93.0671 -5.9131 -2.0737 -4.2467 -0.9417 0.1353 6.7348 3.5906 0.9113 3.3354 0.2017 0.2284 5.7520 1.4648</span> +<span class="r-out co"><span class="r-pr">#></span> 356: 93.0682 -5.9134 -2.0737 -4.2465 -0.9418 0.1352 6.7329 3.5962 0.9113 3.3353 0.2017 0.2283 5.7505 1.4649</span> +<span class="r-out co"><span class="r-pr">#></span> 357: 93.0698 -5.9128 -2.0738 -4.2471 -0.9418 0.1354 6.7397 3.5933 0.9115 3.3388 0.2016 0.2280 5.7512 1.4651</span> +<span class="r-out co"><span class="r-pr">#></span> 358: 93.0709 -5.9129 -2.0740 -4.2475 -0.9419 0.1355 6.7379 3.5915 0.9119 3.3416 0.2016 0.2278 5.7526 1.4644</span> +<span class="r-out co"><span class="r-pr">#></span> 359: 93.0718 -5.9128 -2.0742 -4.2478 -0.9419 0.1358 6.7428 3.5886 0.9123 3.3432 0.2015 0.2275 5.7516 1.4641</span> +<span class="r-out co"><span class="r-pr">#></span> 360: 93.0693 -5.9136 -2.0743 -4.2481 -0.9419 0.1360 6.7385 3.5930 0.9125 3.3443 0.2015 0.2272 5.7511 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 361: 93.0674 -5.9148 -2.0744 -4.2484 -0.9419 0.1361 6.7230 3.6002 0.9127 3.3458 0.2015 0.2270 5.7514 1.4634</span> +<span class="r-out co"><span class="r-pr">#></span> 362: 93.0660 -5.9168 -2.0745 -4.2486 -0.9420 0.1361 6.7313 3.6117 0.9130 3.3473 0.2014 0.2270 5.7506 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 363: 93.0635 -5.9196 -2.0746 -4.2490 -0.9421 0.1360 6.7388 3.6275 0.9132 3.3500 0.2014 0.2269 5.7493 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 364: 93.0631 -5.9210 -2.0747 -4.2497 -0.9421 0.1361 6.7383 3.6323 0.9135 3.3548 0.2015 0.2268 5.7483 1.4634</span> +<span class="r-out co"><span class="r-pr">#></span> 365: 93.0635 -5.9219 -2.0747 -4.2504 -0.9421 0.1361 6.7402 3.6341 0.9137 3.3590 0.2015 0.2268 5.7461 1.4635</span> +<span class="r-out co"><span class="r-pr">#></span> 366: 93.0640 -5.9232 -2.0746 -4.2511 -0.9422 0.1362 6.7477 3.6409 0.9142 3.3624 0.2015 0.2267 5.7451 1.4641</span> +<span class="r-out co"><span class="r-pr">#></span> 367: 93.0616 -5.9247 -2.0746 -4.2518 -0.9422 0.1364 6.7557 3.6473 0.9148 3.3653 0.2015 0.2269 5.7472 1.4640</span> +<span class="r-out co"><span class="r-pr">#></span> 368: 93.0601 -5.9247 -2.0746 -4.2522 -0.9422 0.1366 6.7632 3.6452 0.9150 3.3678 0.2015 0.2270 5.7482 1.4639</span> +<span class="r-out co"><span class="r-pr">#></span> 369: 93.0583 -5.9240 -2.0748 -4.2527 -0.9423 0.1369 6.7737 3.6395 0.9148 3.3695 0.2015 0.2273 5.7499 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 370: 93.0591 -5.9236 -2.0752 -4.2532 -0.9423 0.1373 6.7721 3.6352 0.9145 3.3718 0.2015 0.2276 5.7513 1.4636</span> +<span class="r-out co"><span class="r-pr">#></span> 371: 93.0607 -5.9235 -2.0755 -4.2540 -0.9424 0.1378 6.7682 3.6330 0.9143 3.3754 0.2015 0.2280 5.7535 1.4635</span> +<span class="r-out co"><span class="r-pr">#></span> 372: 93.0615 -5.9229 -2.0759 -4.2549 -0.9424 0.1382 6.7640 3.6288 0.9142 3.3795 0.2014 0.2284 5.7553 1.4633</span> +<span class="r-out co"><span class="r-pr">#></span> 373: 93.0612 -5.9237 -2.0763 -4.2557 -0.9424 0.1385 6.7641 3.6327 0.9140 3.3832 0.2012 0.2288 5.7570 1.4629</span> +<span class="r-out co"><span class="r-pr">#></span> 374: 93.0611 -5.9240 -2.0766 -4.2565 -0.9424 0.1389 6.7701 3.6341 0.9137 3.3872 0.2011 0.2293 5.7599 1.4625</span> +<span class="r-out co"><span class="r-pr">#></span> 375: 93.0615 -5.9247 -2.0770 -4.2573 -0.9424 0.1393 6.7729 3.6362 0.9134 3.3912 0.2009 0.2296 5.7629 1.4620</span> +<span class="r-out co"><span class="r-pr">#></span> 376: 93.0621 -5.9248 -2.0772 -4.2578 -0.9425 0.1397 6.7732 3.6371 0.9132 3.3931 0.2008 0.2298 5.7654 1.4613</span> +<span class="r-out co"><span class="r-pr">#></span> 377: 93.0622 -5.9255 -2.0774 -4.2582 -0.9426 0.1401 6.7681 3.6389 0.9130 3.3953 0.2007 0.2300 5.7678 1.4607</span> +<span class="r-out co"><span class="r-pr">#></span> 378: 93.0609 -5.9256 -2.0775 -4.2585 -0.9426 0.1402 6.7705 3.6381 0.9128 3.3972 0.2006 0.2301 5.7673 1.4602</span> +<span class="r-out co"><span class="r-pr">#></span> 379: 93.0590 -5.9262 -2.0776 -4.2589 -0.9426 0.1404 6.7777 3.6382 0.9127 3.3991 0.2005 0.2303 5.7668 1.4599</span> +<span class="r-out co"><span class="r-pr">#></span> 380: 93.0607 -5.9258 -2.0777 -4.2595 -0.9427 0.1407 6.7836 3.6350 0.9127 3.4031 0.2004 0.2305 5.7665 1.4598</span> +<span class="r-out co"><span class="r-pr">#></span> 381: 93.0617 -5.9251 -2.0777 -4.2596 -0.9427 0.1410 6.7880 3.6294 0.9125 3.4030 0.2003 0.2307 5.7651 1.4601</span> +<span class="r-out co"><span class="r-pr">#></span> 382: 93.0631 -5.9252 -2.0777 -4.2599 -0.9428 0.1413 6.7912 3.6278 0.9123 3.4038 0.2002 0.2310 5.7649 1.4606</span> +<span class="r-out co"><span class="r-pr">#></span> 383: 93.0621 -5.9253 -2.0778 -4.2602 -0.9429 0.1415 6.7834 3.6279 0.9119 3.4053 0.2000 0.2312 5.7657 1.4607</span> +<span class="r-out co"><span class="r-pr">#></span> 384: 93.0614 -5.9254 -2.0779 -4.2604 -0.9430 0.1416 6.7853 3.6280 0.9115 3.4066 0.1999 0.2313 5.7662 1.4608</span> +<span class="r-out co"><span class="r-pr">#></span> 385: 93.0613 -5.9259 -2.0780 -4.2605 -0.9430 0.1418 6.7757 3.6301 0.9112 3.4066 0.1997 0.2315 5.7678 1.4609</span> +<span class="r-out co"><span class="r-pr">#></span> 386: 93.0614 -5.9264 -2.0780 -4.2607 -0.9431 0.1418 6.7610 3.6331 0.9110 3.4073 0.1995 0.2317 5.7696 1.4612</span> +<span class="r-out co"><span class="r-pr">#></span> 387: 93.0631 -5.9276 -2.0780 -4.2610 -0.9432 0.1420 6.7595 3.6397 0.9108 3.4085 0.1993 0.2318 5.7716 1.4612</span> +<span class="r-out co"><span class="r-pr">#></span> 388: 93.0650 -5.9282 -2.0779 -4.2613 -0.9433 0.1421 6.7552 3.6445 0.9106 3.4092 0.1992 0.2318 5.7731 1.4612</span> +<span class="r-out co"><span class="r-pr">#></span> 389: 93.0644 -5.9286 -2.0779 -4.2616 -0.9434 0.1422 6.7488 3.6471 0.9104 3.4098 0.1991 0.2317 5.7724 1.4614</span> +<span class="r-out co"><span class="r-pr">#></span> 390: 93.0653 -5.9297 -2.0778 -4.2619 -0.9435 0.1423 6.7412 3.6524 0.9101 3.4103 0.1990 0.2317 5.7722 1.4615</span> +<span class="r-out co"><span class="r-pr">#></span> 391: 93.0647 -5.9297 -2.0778 -4.2623 -0.9435 0.1425 6.7508 3.6524 0.9101 3.4115 0.1989 0.2317 5.7729 1.4621</span> +<span class="r-out co"><span class="r-pr">#></span> 392: 93.0637 -5.9293 -2.0778 -4.2624 -0.9436 0.1427 6.7572 3.6498 0.9102 3.4109 0.1988 0.2317 5.7727 1.4623</span> +<span class="r-out co"><span class="r-pr">#></span> 393: 93.0657 -5.9294 -2.0778 -4.2632 -0.9436 0.1429 6.7607 3.6496 0.9104 3.4148 0.1987 0.2318 5.7719 1.4621</span> +<span class="r-out co"><span class="r-pr">#></span> 394: 93.0689 -5.9293 -2.0779 -4.2635 -0.9438 0.1431 6.7635 3.6489 0.9108 3.4141 0.1987 0.2318 5.7724 1.4623</span> +<span class="r-out co"><span class="r-pr">#></span> 395: 93.0705 -5.9295 -2.0780 -4.2640 -0.9438 0.1433 6.7753 3.6500 0.9110 3.4145 0.1986 0.2319 5.7724 1.4622</span> +<span class="r-out co"><span class="r-pr">#></span> 396: 93.0704 -5.9296 -2.0780 -4.2648 -0.9438 0.1435 6.7793 3.6511 0.9112 3.4175 0.1985 0.2319 5.7720 1.4618</span> +<span class="r-out co"><span class="r-pr">#></span> 397: 93.0715 -5.9302 -2.0781 -4.2656 -0.9438 0.1437 6.7782 3.6530 0.9114 3.4206 0.1985 0.2320 5.7706 1.4617</span> +<span class="r-out co"><span class="r-pr">#></span> 398: 93.0719 -5.9297 -2.0781 -4.2666 -0.9438 0.1439 6.7774 3.6510 0.9120 3.4258 0.1984 0.2319 5.7709 1.4616</span> +<span class="r-out co"><span class="r-pr">#></span> 399: 93.0720 -5.9296 -2.0781 -4.2678 -0.9438 0.1441 6.7819 3.6526 0.9126 3.4317 0.1984 0.2319 5.7717 1.4615</span> +<span class="r-out co"><span class="r-pr">#></span> 400: 93.0730 -5.9296 -2.0783 -4.2691 -0.9438 0.1443 6.7786 3.6538 0.9129 3.4389 0.1983 0.2319 5.7716 1.4614</span> +<span class="r-out co"><span class="r-pr">#></span> 401: 93.0728 -5.9292 -2.0783 -4.2706 -0.9437 0.1445 6.7731 3.6521 0.9133 3.4478 0.1982 0.2319 5.7701 1.4615</span> +<span class="r-out co"><span class="r-pr">#></span> 402: 93.0732 -5.9289 -2.0784 -4.2718 -0.9438 0.1447 6.7698 3.6517 0.9137 3.4542 0.1981 0.2319 5.7689 1.4618</span> +<span class="r-out co"><span class="r-pr">#></span> 403: 93.0732 -5.9301 -2.0785 -4.2730 -0.9438 0.1450 6.7640 3.6576 0.9142 3.4593 0.1980 0.2320 5.7693 1.4615</span> +<span class="r-out co"><span class="r-pr">#></span> 404: 93.0710 -5.9316 -2.0787 -4.2740 -0.9439 0.1453 6.7544 3.6647 0.9147 3.4644 0.1979 0.2320 5.7708 1.4611</span> +<span class="r-out co"><span class="r-pr">#></span> 405: 93.0687 -5.9322 -2.0788 -4.2750 -0.9440 0.1454 6.7547 3.6663 0.9153 3.4693 0.1978 0.2322 5.7714 1.4608</span> +<span class="r-out co"><span class="r-pr">#></span> 406: 93.0673 -5.9337 -2.0789 -4.2760 -0.9440 0.1456 6.7563 3.6726 0.9163 3.4742 0.1977 0.2324 5.7718 1.4603</span> +<span class="r-out co"><span class="r-pr">#></span> 407: 93.0653 -5.9345 -2.0791 -4.2769 -0.9440 0.1456 6.7601 3.6756 0.9169 3.4786 0.1976 0.2327 5.7732 1.4598</span> +<span class="r-out co"><span class="r-pr">#></span> 408: 93.0640 -5.9357 -2.0793 -4.2779 -0.9440 0.1455 6.7547 3.6821 0.9177 3.4838 0.1974 0.2329 5.7751 1.4592</span> +<span class="r-out co"><span class="r-pr">#></span> 409: 93.0646 -5.9371 -2.0795 -4.2784 -0.9440 0.1456 6.7486 3.6915 0.9184 3.4863 0.1973 0.2330 5.7766 1.4588</span> +<span class="r-out co"><span class="r-pr">#></span> 410: 93.0639 -5.9391 -2.0797 -4.2791 -0.9441 0.1457 6.7523 3.7048 0.9192 3.4889 0.1972 0.2329 5.7770 1.4582</span> +<span class="r-out co"><span class="r-pr">#></span> 411: 93.0628 -5.9401 -2.0799 -4.2799 -0.9442 0.1457 6.7529 3.7113 0.9199 3.4929 0.1972 0.2329 5.7761 1.4580</span> +<span class="r-out co"><span class="r-pr">#></span> 412: 93.0620 -5.9402 -2.0801 -4.2808 -0.9443 0.1458 6.7502 3.7099 0.9207 3.4972 0.1971 0.2328 5.7767 1.4577</span> +<span class="r-out co"><span class="r-pr">#></span> 413: 93.0628 -5.9403 -2.0804 -4.2816 -0.9443 0.1461 6.7466 3.7091 0.9214 3.5007 0.1970 0.2326 5.7771 1.4572</span> +<span class="r-out co"><span class="r-pr">#></span> 414: 93.0627 -5.9405 -2.0807 -4.2825 -0.9443 0.1463 6.7480 3.7089 0.9221 3.5048 0.1969 0.2325 5.7774 1.4567</span> +<span class="r-out co"><span class="r-pr">#></span> 415: 93.0614 -5.9402 -2.0810 -4.2836 -0.9443 0.1465 6.7474 3.7066 0.9226 3.5098 0.1969 0.2323 5.7780 1.4564</span> +<span class="r-out co"><span class="r-pr">#></span> 416: 93.0610 -5.9408 -2.0813 -4.2848 -0.9443 0.1469 6.7544 3.7116 0.9229 3.5157 0.1968 0.2321 5.7786 1.4559</span> +<span class="r-out co"><span class="r-pr">#></span> 417: 93.0601 -5.9413 -2.0815 -4.2860 -0.9443 0.1471 6.7592 3.7158 0.9234 3.5206 0.1967 0.2319 5.7793 1.4556</span> +<span class="r-out co"><span class="r-pr">#></span> 418: 93.0606 -5.9424 -2.0817 -4.2868 -0.9444 0.1473 6.7589 3.7214 0.9238 3.5237 0.1966 0.2318 5.7787 1.4553</span> +<span class="r-out co"><span class="r-pr">#></span> 419: 93.0605 -5.9433 -2.0818 -4.2877 -0.9444 0.1476 6.7641 3.7253 0.9242 3.5274 0.1965 0.2316 5.7780 1.4552</span> +<span class="r-out co"><span class="r-pr">#></span> 420: 93.0623 -5.9427 -2.0819 -4.2886 -0.9445 0.1478 6.7593 3.7216 0.9246 3.5310 0.1965 0.2314 5.7772 1.4551</span> +<span class="r-out co"><span class="r-pr">#></span> 421: 93.0630 -5.9418 -2.0819 -4.2895 -0.9445 0.1480 6.7489 3.7166 0.9250 3.5337 0.1964 0.2312 5.7764 1.4552</span> +<span class="r-out co"><span class="r-pr">#></span> 422: 93.0626 -5.9410 -2.0820 -4.2900 -0.9445 0.1482 6.7452 3.7124 0.9253 3.5350 0.1963 0.2311 5.7758 1.4549</span> +<span class="r-out co"><span class="r-pr">#></span> 423: 93.0629 -5.9407 -2.0822 -4.2906 -0.9446 0.1484 6.7409 3.7095 0.9256 3.5360 0.1963 0.2309 5.7753 1.4546</span> +<span class="r-out co"><span class="r-pr">#></span> 424: 93.0637 -5.9404 -2.0821 -4.2912 -0.9446 0.1485 6.7387 3.7073 0.9258 3.5370 0.1962 0.2308 5.7733 1.4546</span> +<span class="r-out co"><span class="r-pr">#></span> 425: 93.0625 -5.9402 -2.0821 -4.2917 -0.9447 0.1486 6.7330 3.7061 0.9258 3.5381 0.1961 0.2306 5.7722 1.4548</span> +<span class="r-out co"><span class="r-pr">#></span> 426: 93.0624 -5.9399 -2.0820 -4.2921 -0.9447 0.1487 6.7256 3.7034 0.9259 3.5387 0.1961 0.2304 5.7719 1.4545</span> +<span class="r-out co"><span class="r-pr">#></span> 427: 93.0606 -5.9397 -2.0821 -4.2925 -0.9447 0.1488 6.7139 3.7010 0.9257 3.5394 0.1961 0.2301 5.7730 1.4545</span> +<span class="r-out co"><span class="r-pr">#></span> 428: 93.0601 -5.9394 -2.0822 -4.2929 -0.9447 0.1489 6.7062 3.6984 0.9256 3.5405 0.1961 0.2298 5.7723 1.4543</span> +<span class="r-out co"><span class="r-pr">#></span> 429: 93.0615 -5.9391 -2.0821 -4.2933 -0.9447 0.1490 6.7040 3.6956 0.9254 3.5412 0.1960 0.2297 5.7714 1.4544</span> +<span class="r-out co"><span class="r-pr">#></span> 430: 93.0654 -5.9389 -2.0820 -4.2934 -0.9448 0.1491 6.7016 3.6934 0.9253 3.5412 0.1960 0.2295 5.7710 1.4546</span> +<span class="r-out co"><span class="r-pr">#></span> 431: 93.0674 -5.9392 -2.0819 -4.2936 -0.9449 0.1491 6.6946 3.6935 0.9252 3.5414 0.1960 0.2294 5.7699 1.4547</span> +<span class="r-out co"><span class="r-pr">#></span> 432: 93.0683 -5.9401 -2.0818 -4.2938 -0.9450 0.1491 6.6895 3.6960 0.9250 3.5417 0.1961 0.2292 5.7687 1.4549</span> +<span class="r-out co"><span class="r-pr">#></span> 433: 93.0693 -5.9411 -2.0815 -4.2942 -0.9451 0.1491 6.6826 3.7003 0.9254 3.5433 0.1961 0.2291 5.7679 1.4549</span> +<span class="r-out co"><span class="r-pr">#></span> 434: 93.0720 -5.9410 -2.0813 -4.2945 -0.9452 0.1491 6.6842 3.6998 0.9258 3.5440 0.1960 0.2290 5.7662 1.4548</span> +<span class="r-out co"><span class="r-pr">#></span> 435: 93.0735 -5.9417 -2.0811 -4.2947 -0.9453 0.1490 6.6907 3.7029 0.9261 3.5446 0.1960 0.2290 5.7651 1.4548</span> +<span class="r-out co"><span class="r-pr">#></span> 436: 93.0752 -5.9430 -2.0809 -4.2949 -0.9454 0.1489 6.6939 3.7083 0.9266 3.5459 0.1959 0.2290 5.7638 1.4547</span> +<span class="r-out co"><span class="r-pr">#></span> 437: 93.0774 -5.9442 -2.0807 -4.2952 -0.9455 0.1487 6.7016 3.7147 0.9270 3.5474 0.1960 0.2290 5.7624 1.4550</span> +<span class="r-out co"><span class="r-pr">#></span> 438: 93.0795 -5.9453 -2.0805 -4.2954 -0.9456 0.1485 6.7089 3.7212 0.9275 3.5491 0.1959 0.2291 5.7614 1.4551</span> +<span class="r-out co"><span class="r-pr">#></span> 439: 93.0816 -5.9467 -2.0802 -4.2956 -0.9457 0.1484 6.7230 3.7291 0.9281 3.5503 0.1959 0.2293 5.7616 1.4551</span> +<span class="r-out co"><span class="r-pr">#></span> 440: 93.0834 -5.9475 -2.0800 -4.2957 -0.9458 0.1480 6.7306 3.7340 0.9287 3.5512 0.1960 0.2295 5.7631 1.4551</span> +<span class="r-out co"><span class="r-pr">#></span> 441: 93.0855 -5.9480 -2.0797 -4.2961 -0.9459 0.1478 6.7436 3.7373 0.9292 3.5534 0.1960 0.2299 5.7642 1.4553</span> +<span class="r-out co"><span class="r-pr">#></span> 442: 93.0885 -5.9488 -2.0793 -4.2963 -0.9460 0.1474 6.7533 3.7419 0.9297 3.5546 0.1960 0.2304 5.7630 1.4554</span> +<span class="r-out co"><span class="r-pr">#></span> 443: 93.0907 -5.9497 -2.0789 -4.2967 -0.9461 0.1471 6.7641 3.7469 0.9304 3.5570 0.1960 0.2308 5.7616 1.4554</span> +<span class="r-out co"><span class="r-pr">#></span> 444: 93.0905 -5.9504 -2.0785 -4.2972 -0.9462 0.1467 6.7570 3.7486 0.9312 3.5601 0.1960 0.2311 5.7604 1.4553</span> +<span class="r-out co"><span class="r-pr">#></span> 445: 93.0903 -5.9515 -2.0782 -4.2977 -0.9462 0.1462 6.7547 3.7543 0.9319 3.5635 0.1960 0.2314 5.7595 1.4550</span> +<span class="r-out co"><span class="r-pr">#></span> 446: 93.0902 -5.9530 -2.0778 -4.2982 -0.9462 0.1459 6.7562 3.7615 0.9325 3.5664 0.1960 0.2316 5.7580 1.4548</span> +<span class="r-out co"><span class="r-pr">#></span> 447: 93.0905 -5.9541 -2.0775 -4.2990 -0.9463 0.1455 6.7639 3.7668 0.9333 3.5719 0.1960 0.2318 5.7574 1.4543</span> +<span class="r-out co"><span class="r-pr">#></span> 448: 93.0912 -5.9555 -2.0772 -4.2999 -0.9463 0.1452 6.7671 3.7736 0.9340 3.5783 0.1960 0.2322 5.7572 1.4540</span> +<span class="r-out co"><span class="r-pr">#></span> 449: 93.0918 -5.9570 -2.0769 -4.3004 -0.9464 0.1448 6.7824 3.7802 0.9345 3.5809 0.1960 0.2326 5.7561 1.4537</span> +<span class="r-out co"><span class="r-pr">#></span> 450: 93.0901 -5.9579 -2.0766 -4.3011 -0.9464 0.1444 6.7866 3.7829 0.9351 3.5853 0.1959 0.2329 5.7551 1.4536</span> +<span class="r-out co"><span class="r-pr">#></span> 451: 93.0899 -5.9594 -2.0763 -4.3016 -0.9465 0.1439 6.7875 3.7896 0.9356 3.5888 0.1959 0.2332 5.7550 1.4537</span> +<span class="r-out co"><span class="r-pr">#></span> 452: 93.0902 -5.9603 -2.0759 -4.3023 -0.9465 0.1435 6.7953 3.7926 0.9363 3.5927 0.1958 0.2335 5.7537 1.4538</span> +<span class="r-out co"><span class="r-pr">#></span> 453: 93.0906 -5.9615 -2.0755 -4.3026 -0.9465 0.1430 6.7996 3.7982 0.9372 3.5950 0.1958 0.2338 5.7531 1.4539</span> +<span class="r-out co"><span class="r-pr">#></span> 454: 93.0909 -5.9614 -2.0751 -4.3029 -0.9465 0.1425 6.8016 3.7969 0.9381 3.5976 0.1958 0.2340 5.7532 1.4540</span> +<span class="r-out co"><span class="r-pr">#></span> 455: 93.0909 -5.9610 -2.0749 -4.3035 -0.9464 0.1420 6.8022 3.7940 0.9391 3.6022 0.1957 0.2342 5.7532 1.4539</span> +<span class="r-out co"><span class="r-pr">#></span> 456: 93.0916 -5.9600 -2.0746 -4.3045 -0.9463 0.1416 6.7942 3.7893 0.9398 3.6104 0.1957 0.2344 5.7540 1.4537</span> +<span class="r-out co"><span class="r-pr">#></span> 457: 93.0905 -5.9595 -2.0744 -4.3058 -0.9463 0.1411 6.7931 3.7866 0.9407 3.6210 0.1956 0.2345 5.7551 1.4534</span> +<span class="r-out co"><span class="r-pr">#></span> 458: 93.0905 -5.9597 -2.0742 -4.3071 -0.9462 0.1407 6.7877 3.7882 0.9416 3.6327 0.1955 0.2347 5.7566 1.4532</span> +<span class="r-out co"><span class="r-pr">#></span> 459: 93.0895 -5.9598 -2.0741 -4.3078 -0.9461 0.1402 6.7884 3.7889 0.9425 3.6383 0.1955 0.2349 5.7601 1.4527</span> +<span class="r-out co"><span class="r-pr">#></span> 460: 93.0871 -5.9602 -2.0741 -4.3086 -0.9460 0.1398 6.7889 3.7912 0.9434 3.6439 0.1954 0.2350 5.7619 1.4522</span> +<span class="r-out co"><span class="r-pr">#></span> 461: 93.0854 -5.9613 -2.0739 -4.3091 -0.9459 0.1393 6.7813 3.7973 0.9440 3.6481 0.1953 0.2351 5.7620 1.4520</span> +<span class="r-out co"><span class="r-pr">#></span> 462: 93.0838 -5.9623 -2.0737 -4.3093 -0.9458 0.1388 6.7791 3.8037 0.9445 3.6498 0.1953 0.2353 5.7616 1.4518</span> +<span class="r-out co"><span class="r-pr">#></span> 463: 93.0816 -5.9629 -2.0734 -4.3095 -0.9457 0.1384 6.7733 3.8070 0.9451 3.6508 0.1952 0.2355 5.7626 1.4519</span> +<span class="r-out co"><span class="r-pr">#></span> 464: 93.0792 -5.9631 -2.0731 -4.3095 -0.9457 0.1379 6.7697 3.8081 0.9460 3.6507 0.1951 0.2358 5.7638 1.4518</span> +<span class="r-out co"><span class="r-pr">#></span> 465: 93.0775 -5.9633 -2.0728 -4.3095 -0.9456 0.1374 6.7717 3.8095 0.9466 3.6506 0.1950 0.2361 5.7647 1.4519</span> +<span class="r-out co"><span class="r-pr">#></span> 466: 93.0774 -5.9640 -2.0725 -4.3097 -0.9455 0.1368 6.7686 3.8141 0.9473 3.6516 0.1949 0.2363 5.7662 1.4516</span> +<span class="r-out co"><span class="r-pr">#></span> 467: 93.0773 -5.9646 -2.0722 -4.3100 -0.9454 0.1364 6.7668 3.8172 0.9480 3.6535 0.1948 0.2366 5.7671 1.4516</span> +<span class="r-out co"><span class="r-pr">#></span> 468: 93.0777 -5.9653 -2.0719 -4.3106 -0.9453 0.1358 6.7648 3.8226 0.9487 3.6566 0.1947 0.2371 5.7681 1.4514</span> +<span class="r-out co"><span class="r-pr">#></span> 469: 93.0778 -5.9657 -2.0717 -4.3112 -0.9453 0.1353 6.7617 3.8253 0.9495 3.6588 0.1947 0.2375 5.7686 1.4510</span> +<span class="r-out co"><span class="r-pr">#></span> 470: 93.0769 -5.9663 -2.0715 -4.3117 -0.9452 0.1347 6.7650 3.8278 0.9503 3.6613 0.1947 0.2379 5.7688 1.4506</span> +<span class="r-out co"><span class="r-pr">#></span> 471: 93.0749 -5.9664 -2.0714 -4.3123 -0.9451 0.1342 6.7708 3.8280 0.9510 3.6643 0.1947 0.2383 5.7699 1.4505</span> +<span class="r-out co"><span class="r-pr">#></span> 472: 93.0721 -5.9668 -2.0713 -4.3127 -0.9450 0.1337 6.7756 3.8284 0.9517 3.6665 0.1947 0.2386 5.7710 1.4501</span> +<span class="r-out co"><span class="r-pr">#></span> 473: 93.0696 -5.9670 -2.0713 -4.3133 -0.9449 0.1333 6.7784 3.8280 0.9522 3.6698 0.1947 0.2388 5.7716 1.4498</span> +<span class="r-out co"><span class="r-pr">#></span> 474: 93.0674 -5.9673 -2.0714 -4.3138 -0.9448 0.1329 6.7761 3.8281 0.9527 3.6731 0.1947 0.2390 5.7729 1.4496</span> +<span class="r-out co"><span class="r-pr">#></span> 475: 93.0655 -5.9679 -2.0714 -4.3143 -0.9447 0.1324 6.7779 3.8302 0.9531 3.6762 0.1947 0.2391 5.7743 1.4493</span> +<span class="r-out co"><span class="r-pr">#></span> 476: 93.0643 -5.9682 -2.0713 -4.3144 -0.9447 0.1321 6.7776 3.8314 0.9536 3.6768 0.1946 0.2391 5.7762 1.4492</span> +<span class="r-out co"><span class="r-pr">#></span> 477: 93.0631 -5.9684 -2.0714 -4.3146 -0.9446 0.1317 6.7725 3.8326 0.9540 3.6787 0.1945 0.2392 5.7768 1.4492</span> +<span class="r-out co"><span class="r-pr">#></span> 478: 93.0630 -5.9693 -2.0715 -4.3148 -0.9447 0.1314 6.7626 3.8365 0.9543 3.6788 0.1944 0.2395 5.7785 1.4492</span> +<span class="r-out co"><span class="r-pr">#></span> 479: 93.0634 -5.9710 -2.0714 -4.3148 -0.9447 0.1310 6.7499 3.8462 0.9547 3.6778 0.1943 0.2399 5.7798 1.4490</span> +<span class="r-out co"><span class="r-pr">#></span> 480: 93.0651 -5.9732 -2.0715 -4.3147 -0.9447 0.1307 6.7463 3.8616 0.9548 3.6770 0.1943 0.2403 5.7810 1.4488</span> +<span class="r-out co"><span class="r-pr">#></span> 481: 93.0664 -5.9747 -2.0715 -4.3149 -0.9447 0.1304 6.7442 3.8722 0.9550 3.6780 0.1941 0.2409 5.7811 1.4487</span> +<span class="r-out co"><span class="r-pr">#></span> 482: 93.0647 -5.9762 -2.0714 -4.3151 -0.9447 0.1300 6.7389 3.8834 0.9554 3.6784 0.1941 0.2414 5.7816 1.4484</span> +<span class="r-out co"><span class="r-pr">#></span> 483: 93.0628 -5.9778 -2.0714 -4.3153 -0.9447 0.1295 6.7352 3.8943 0.9557 3.6783 0.1940 0.2419 5.7820 1.4483</span> +<span class="r-out co"><span class="r-pr">#></span> 484: 93.0614 -5.9787 -2.0715 -4.3153 -0.9447 0.1291 6.7314 3.8999 0.9559 3.6774 0.1939 0.2424 5.7819 1.4481</span> +<span class="r-out co"><span class="r-pr">#></span> 485: 93.0593 -5.9789 -2.0715 -4.3153 -0.9447 0.1288 6.7293 3.9007 0.9561 3.6765 0.1938 0.2430 5.7815 1.4480</span> +<span class="r-out co"><span class="r-pr">#></span> 486: 93.0575 -5.9793 -2.0716 -4.3152 -0.9447 0.1284 6.7331 3.9021 0.9563 3.6753 0.1938 0.2434 5.7806 1.4480</span> +<span class="r-out co"><span class="r-pr">#></span> 487: 93.0555 -5.9796 -2.0716 -4.3152 -0.9447 0.1281 6.7342 3.9036 0.9566 3.6741 0.1937 0.2439 5.7805 1.4479</span> +<span class="r-out co"><span class="r-pr">#></span> 488: 93.0545 -5.9795 -2.0716 -4.3152 -0.9447 0.1277 6.7365 3.9024 0.9569 3.6729 0.1937 0.2444 5.7795 1.4480</span> +<span class="r-out co"><span class="r-pr">#></span> 489: 93.0550 -5.9800 -2.0716 -4.3152 -0.9447 0.1274 6.7336 3.9046 0.9571 3.6719 0.1937 0.2448 5.7778 1.4481</span> +<span class="r-out co"><span class="r-pr">#></span> 490: 93.0571 -5.9793 -2.0715 -4.3152 -0.9447 0.1272 6.7331 3.9009 0.9573 3.6704 0.1936 0.2450 5.7767 1.4484</span> +<span class="r-out co"><span class="r-pr">#></span> 491: 93.0584 -5.9787 -2.0714 -4.3151 -0.9447 0.1270 6.7280 3.8980 0.9575 3.6688 0.1936 0.2452 5.7764 1.4487</span> +<span class="r-out co"><span class="r-pr">#></span> 492: 93.0589 -5.9786 -2.0714 -4.3150 -0.9447 0.1267 6.7264 3.8971 0.9578 3.6675 0.1936 0.2455 5.7759 1.4489</span> +<span class="r-out co"><span class="r-pr">#></span> 493: 93.0593 -5.9790 -2.0711 -4.3149 -0.9447 0.1265 6.7273 3.8982 0.9584 3.6660 0.1935 0.2456 5.7759 1.4490</span> +<span class="r-out co"><span class="r-pr">#></span> 494: 93.0594 -5.9805 -2.0710 -4.3149 -0.9448 0.1263 6.7291 3.9066 0.9590 3.6650 0.1935 0.2457 5.7758 1.4489</span> +<span class="r-out co"><span class="r-pr">#></span> 495: 93.0596 -5.9816 -2.0709 -4.3148 -0.9448 0.1261 6.7281 3.9123 0.9593 3.6639 0.1936 0.2459 5.7745 1.4490</span> +<span class="r-out co"><span class="r-pr">#></span> 496: 93.0590 -5.9829 -2.0707 -4.3148 -0.9448 0.1259 6.7319 3.9227 0.9597 3.6628 0.1936 0.2461 5.7740 1.4491</span> +<span class="r-out co"><span class="r-pr">#></span> 497: 93.0580 -5.9842 -2.0706 -4.3148 -0.9448 0.1257 6.7388 3.9326 0.9600 3.6623 0.1936 0.2463 5.7732 1.4492</span> +<span class="r-out co"><span class="r-pr">#></span> 498: 93.0578 -5.9848 -2.0705 -4.3148 -0.9448 0.1255 6.7447 3.9368 0.9605 3.6618 0.1936 0.2464 5.7726 1.4494</span> +<span class="r-out co"><span class="r-pr">#></span> 499: 93.0568 -5.9843 -2.0704 -4.3147 -0.9447 0.1253 6.7475 3.9341 0.9609 3.6612 0.1937 0.2467 5.7718 1.4495</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 93.0563 -5.9831 -2.0703 -4.3147 -0.9447 0.1251 6.7500 3.9292 0.9614 3.6607 0.1937 0.2469 5.7712 1.4496</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis |sigma_parent | sigma_A1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 488.98943 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.98943 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.98943</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -27.68 | 2.403 | -0.1248 | -0.3242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3705 | 0.07384 | -31.92 | -15.13 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 14.74 | 13.03 | -12.01 | -2.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 5.553 | -10.09 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1205.4696 | 1.534 | -1.046 | -0.9091 | -0.9266 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9745 | -0.8897 | -0.2358 | -0.5780 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.162 | -1.126 | -0.6367 | -0.8323 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9817 | -0.6738 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 1205.4696 | 142.6 | -5.346 | -0.9477 | -1.994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.393 | 0.1897 | 2.616 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5160 | 0.6557 | 1.444 | 1.015 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7709 | 1.387 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1205.4696</span> | 142.6 | 0.004766 | 0.2793 | 0.1362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01237 | 0.5473 | 2.616 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5160 | 0.6557 | 1.444 | 1.015 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7709 | 1.387 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 510.70816 | 1.053 | -1.005 | -0.9113 | -0.9322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9810 | -0.8884 | -0.7899 | -0.8406 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9059 | -0.8995 | -0.8452 | -0.8683 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8853 | -0.8491 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 510.70816 | 97.96 | -5.305 | -0.9498 | -1.999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.399 | 0.1900 | 2.062 | 1.116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7005 | 0.8538 | 1.199 | 0.9804 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8541 | 1.184 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 510.70816</span> | 97.96 | 0.004969 | 0.2789 | 0.1354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01229 | 0.5474 | 2.062 | 1.116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7005 | 0.8538 | 1.199 | 0.9804 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8541 | 1.184 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 494.11470 | 1.005 | -1.000 | -0.9115 | -0.9328 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9816 | -0.8883 | -0.8453 | -0.8669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8803 | -0.8769 | -0.8660 | -0.8719 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8757 | -0.8666 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.1147 | 93.50 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.006 | 1.102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7190 | 0.8736 | 1.175 | 0.9768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8624 | 1.163 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.1147</span> | 93.50 | 0.004989 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.006 | 1.102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7190 | 0.8736 | 1.175 | 0.9768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8624 | 1.163 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 494.35784 | 1.001 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8509 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8778 | -0.8746 | -0.8681 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8747 | -0.8683 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.35784 | 93.05 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.001 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7208 | 0.8755 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8632 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.35784</span> | 93.05 | 0.004991 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.001 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7208 | 0.8755 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8632 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 494.40319 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8514 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8744 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40319 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8757 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40319</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8757 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 494.40793 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8744 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40793 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40793</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 494.40830 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.4083 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.4083</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance, can check sandwich or S matrix with $covRS and $covS</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Identical two-component error for all variables is only possible with</span></span> +<span class="r-in"><span class="co"># est = 'focei' in nlmixr</span></span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta | sigma_low | rsd_high | o1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 500.20030 | 1.000 | -1.000 | -0.9113 | -0.8944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8678 | -0.8916 | -0.8767 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8743 | -0.8675 | -0.8704 | -0.8704 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 500.2003 | 93.00 | -5.300 | -0.9400 | -0.1100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.200 | 0.03000 | 0.7598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.214 | 1.068 | 1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 500.2003</span> | 93.00 | 0.004992 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.200 | 0.03000 | 0.7598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.214 | 1.068 | 1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 48.88 | 2.383 | 0.1231 | 0.1986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1571 | -64.31 | -21.89 | 0.6250 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.41 | -12.48 | -9.903 | -10.91 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2909.4393 | 0.4361 | -1.027 | -0.9127 | -0.8967 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8472 | -0.1258 | -0.6390 | -0.8839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.7235 | -0.7562 | -0.7445 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 2909.4393 | 40.56 | -5.327 | -0.9413 | -0.1123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.645 | 0.03379 | 0.7544 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7605 | 1.389 | 1.189 | 1.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2909.4393</span> | 40.56 | 0.004856 | 0.2806 | 0.8938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.956 | 1.645 | 0.03379 | 0.7544 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7605 | 1.389 | 1.189 | 1.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 515.24373 | 0.9436 | -1.003 | -0.9114 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7936 | -0.8663 | -0.8774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8875 | -0.8531 | -0.8590 | -0.8578 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 515.24373 | 87.76 | -5.303 | -0.9401 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.245 | 0.03038 | 0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8642 | 1.232 | 1.080 | 1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 515.24373</span> | 87.76 | 0.004978 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.245 | 0.03038 | 0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8642 | 1.232 | 1.080 | 1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 499.40695 | 0.9897 | -1.001 | -0.9113 | -0.8944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8542 | -0.8869 | -0.8768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8768 | -0.8648 | -0.8684 | -0.8681 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 499.40695 | 92.04 | -5.301 | -0.9400 | -0.1100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.208 | 0.03007 | 0.7597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8737 | 1.217 | 1.070 | 1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 499.40695</span> | 92.04 | 0.004989 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.208 | 0.03007 | 0.7597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8737 | 1.217 | 1.070 | 1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -99.71 | 2.245 | -0.1707 | 0.1202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1546 | -61.69 | -22.54 | 1.475 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.677 | -11.72 | -9.584 | -10.53 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 498.17135 | 1.001 | -1.001 | -0.9113 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8410 | -0.8822 | -0.8771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8786 | -0.8623 | -0.8663 | -0.8658 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 498.17135 | 93.06 | -5.301 | -0.9400 | -0.1101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.216 | 0.03014 | 0.7595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8720 | 1.221 | 1.072 | 1.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 498.17135</span> | 93.06 | 0.004987 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.216 | 0.03014 | 0.7595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8720 | 1.221 | 1.072 | 1.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.25 | 2.349 | 0.1359 | 0.2180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1993 | -60.48 | -20.28 | 1.106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.662 | -11.74 | -9.501 | -10.55 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 497.33758 | 0.9906 | -1.002 | -0.9113 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8273 | -0.8776 | -0.8773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8808 | -0.8596 | -0.8642 | -0.8634 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 497.33758 | 92.12 | -5.302 | -0.9400 | -0.1101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.224 | 0.03021 | 0.7594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8701 | 1.224 | 1.074 | 1.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 497.33758</span> | 92.12 | 0.004984 | 0.2809 | 0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.224 | 0.03021 | 0.7594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8701 | 1.224 | 1.074 | 1.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -88.13 | 2.220 | -0.1371 | 0.1382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1101 | -57.44 | -20.90 | 1.111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.358 | -11.52 | -9.371 | -10.34 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 496.20963 | 1.001 | -1.002 | -0.9113 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8137 | -0.8728 | -0.8776 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8827 | -0.8569 | -0.8620 | -0.8610 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 496.20963 | 93.07 | -5.302 | -0.9400 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.232 | 0.03028 | 0.7592 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8684 | 1.227 | 1.077 | 1.081 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.20963</span> | 93.07 | 0.004981 | 0.2809 | 0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.232 | 0.03028 | 0.7592 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8684 | 1.227 | 1.077 | 1.081 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.31 | 2.316 | 0.1573 | 0.2363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2327 | -56.27 | -18.79 | 0.9054 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.277 | -11.53 | -9.283 | -10.35 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 495.35926 | 0.9914 | -1.003 | -0.9113 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7996 | -0.8680 | -0.8778 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8850 | -0.8541 | -0.8597 | -0.8584 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.35926 | 92.20 | -5.303 | -0.9401 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.241 | 0.03035 | 0.7590 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8664 | 1.231 | 1.079 | 1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.35926</span> | 92.20 | 0.004979 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.241 | 0.03035 | 0.7590 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8664 | 1.231 | 1.079 | 1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -77.78 | 2.194 | -0.1077 | 0.1552 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06714 | -52.97 | -19.27 | 0.8916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.037 | -11.29 | -9.130 | -10.15 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 494.33654 | 1.001 | -1.003 | -0.9113 | -0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7857 | -0.8631 | -0.8780 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8870 | -0.8511 | -0.8573 | -0.8558 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.33654 | 93.09 | -5.303 | -0.9400 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.249 | 0.03043 | 0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8647 | 1.234 | 1.082 | 1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.33654</span> | 93.09 | 0.004976 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.249 | 0.03043 | 0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8647 | 1.234 | 1.082 | 1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.95 | 2.282 | 0.1850 | 0.2507 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2656 | -51.81 | -17.28 | 0.8212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.543 | -11.27 | -9.029 | -10.13 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 493.47922 | 0.9922 | -1.004 | -0.9114 | -0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7714 | -0.8582 | -0.8782 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8891 | -0.8480 | -0.8548 | -0.8530 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 493.47922 | 92.28 | -5.304 | -0.9401 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.258 | 0.03050 | 0.7587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8629 | 1.238 | 1.084 | 1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.47922</span> | 92.28 | 0.004973 | 0.2809 | 0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.258 | 0.03050 | 0.7587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8629 | 1.238 | 1.084 | 1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -67.18 | 2.173 | -0.07166 | 0.1818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01313 | -49.19 | -17.69 | 0.7047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.114 | -11.03 | -8.882 | -9.923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 492.53845 | 1.001 | -1.004 | -0.9114 | -0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7572 | -0.8532 | -0.8784 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8914 | -0.8448 | -0.8522 | -0.8501 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 492.53845 | 93.09 | -5.304 | -0.9401 | -0.1104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.266 | 0.03057 | 0.7585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8608 | 1.242 | 1.087 | 1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.53845</span> | 93.09 | 0.004969 | 0.2809 | 0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.266 | 0.03057 | 0.7585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8608 | 1.242 | 1.087 | 1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 53.38 | 2.243 | 0.1941 | 0.2566 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2879 | -47.96 | -15.83 | 0.7595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.537 | -10.98 | -8.771 | -9.890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 491.72645 | 0.9926 | -1.005 | -0.9114 | -0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7429 | -0.8484 | -0.8786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8941 | -0.8415 | -0.8496 | -0.8471 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.72645 | 92.31 | -5.305 | -0.9401 | -0.1105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.275 | 0.03065 | 0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8584 | 1.246 | 1.090 | 1.096 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.72645</span> | 92.31 | 0.004966 | 0.2809 | 0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.275 | 0.03065 | 0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8584 | 1.246 | 1.090 | 1.096 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -63.56 | 2.131 | -0.05387 | 0.1833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.0009134 | -45.55 | -16.30 | 0.3872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.447 | -10.76 | -8.612 | -9.684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 490.83850 | 1.001 | -1.006 | -0.9114 | -0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8457 | -0.7286 | -0.8435 | -0.8787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -0.8380 | -0.8468 | -0.8440 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.8385 | 93.07 | -5.306 | -0.9401 | -0.1105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.283 | 0.03072 | 0.7583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8556 | 1.250 | 1.093 | 1.099 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.8385</span> | 93.07 | 0.004963 | 0.2809 | 0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.971 | 1.283 | 0.03072 | 0.7583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8556 | 1.250 | 1.093 | 1.099 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.01 | 2.198 | 0.2057 | 0.2666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3102 | -44.06 | -14.52 | 0.5614 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.039 | -10.72 | -8.482 | -9.628 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 490.09324 | 0.9928 | -1.007 | -0.9115 | -0.8950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8458 | -0.7143 | -0.8387 | -0.8788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.8343 | -0.8439 | -0.8407 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.09324 | 92.33 | -5.307 | -0.9402 | -0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.292 | 0.03079 | 0.7582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8529 | 1.254 | 1.096 | 1.103 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.09324</span> | 92.33 | 0.004959 | 0.2809 | 0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.970 | 1.292 | 0.03079 | 0.7582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8529 | 1.254 | 1.096 | 1.103 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -62.13 | 2.095 | -0.03472 | 0.1999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03562 | -41.55 | -14.84 | 0.5236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.264 | -10.46 | -8.310 | -9.412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 489.25271 | 1.001 | -1.007 | -0.9115 | -0.8951 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8458 | -0.7001 | -0.8338 | -0.8789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | -0.8304 | -0.8408 | -0.8372 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 489.25271 | 93.06 | -5.307 | -0.9402 | -0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.301 | 0.03087 | 0.7581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8505 | 1.259 | 1.099 | 1.107 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.25271</span> | 93.06 | 0.004955 | 0.2809 | 0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.970 | 1.301 | 0.03087 | 0.7581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8505 | 1.259 | 1.099 | 1.107 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 44.98 | 2.155 | 0.2191 | 0.2769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3339 | -40.42 | -13.24 | 0.4473 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.595 | -10.35 | -8.165 | -9.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 488.54089 | 0.9934 | -1.008 | -0.9116 | -0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8459 | -0.6857 | -0.8290 | -0.8790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9061 | -0.8262 | -0.8376 | -0.8335 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.54089 | 92.38 | -5.308 | -0.9403 | -0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.309 | 0.03094 | 0.7581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8479 | 1.264 | 1.103 | 1.111 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.54089</span> | 92.38 | 0.004951 | 0.2808 | 0.8951 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.968 | 1.309 | 0.03094 | 0.7581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8479 | 1.264 | 1.103 | 1.111 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -55.81 | 2.061 | -0.02096 | 0.2050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07367 | -38.08 | -13.50 | 0.4111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.904 | -10.08 | -7.981 | -9.106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 487.77387 | 1.001 | -1.009 | -0.9116 | -0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8461 | -0.6716 | -0.8243 | -0.8791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9092 | -0.8218 | -0.8341 | -0.8294 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.77387 | 93.07 | -5.309 | -0.9403 | -0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.318 | 0.03101 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 1.270 | 1.106 | 1.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.77387</span> | 93.07 | 0.004946 | 0.2808 | 0.8950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.967 | 1.318 | 0.03101 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 1.270 | 1.106 | 1.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 43.45 | 2.114 | 0.2402 | 0.2940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | -36.87 | -12.03 | 0.3081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.143 | -10.02 | -7.799 | -9.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 487.09815 | 0.9939 | -1.010 | -0.9118 | -0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8463 | -0.6575 | -0.8197 | -0.8791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9124 | -0.8169 | -0.8304 | -0.8251 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.09815 | 92.43 | -5.310 | -0.9404 | -0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.326 | 0.03108 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8425 | 1.276 | 1.110 | 1.120 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.09815</span> | 92.43 | 0.004941 | 0.2808 | 0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.965 | 1.326 | 0.03108 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8425 | 1.276 | 1.110 | 1.120 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.03 | 2.024 | 0.005993 | 0.2193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1119 | -34.69 | -12.26 | 0.2072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.453 | -9.722 | -7.597 | -8.758 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 486.39882 | 1.001 | -1.011 | -0.9119 | -0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8465 | -0.6438 | -0.8151 | -0.8789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9156 | -0.8116 | -0.8264 | -0.8203 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 486.39882 | 93.07 | -5.311 | -0.9405 | -0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.334 | 0.03115 | 0.7582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8396 | 1.282 | 1.114 | 1.125 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.39882</span> | 93.07 | 0.004935 | 0.2808 | 0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.963 | 1.334 | 0.03115 | 0.7582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8396 | 1.282 | 1.114 | 1.125 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.24 | 2.069 | 0.2581 | 0.3038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3965 | -33.71 | -10.93 | 0.1523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.279 | -9.597 | -7.397 | -8.617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 485.77269 | 0.9943 | -1.013 | -0.9120 | -0.8959 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.6301 | -0.8107 | -0.8786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9175 | -0.8058 | -0.8222 | -0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.77269 | 92.47 | -5.313 | -0.9407 | -0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.343 | 0.03121 | 0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 1.289 | 1.119 | 1.130 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.77269</span> | 92.47 | 0.004928 | 0.2808 | 0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.960 | 1.343 | 0.03121 | 0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 1.289 | 1.119 | 1.130 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -45.38 | 1.992 | 0.03513 | 0.2356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1513 | -31.62 | -11.12 | 0.08802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.113 | -9.278 | -7.167 | -8.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 485.13787 | 1.001 | -1.014 | -0.9122 | -0.8962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.6169 | -0.8065 | -0.8780 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9196 | -0.7993 | -0.8176 | -0.8094 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.13787 | 93.06 | -5.314 | -0.9409 | -0.1118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.351 | 0.03128 | 0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8361 | 1.297 | 1.124 | 1.136 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.13787</span> | 93.06 | 0.004921 | 0.2807 | 0.8942 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.957 | 1.351 | 0.03128 | 0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8361 | 1.297 | 1.124 | 1.136 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 37.95 | 2.033 | 0.2726 | 0.3147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4223 | -30.68 | -9.906 | 0.05100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.975 | -9.039 | -6.928 | -8.144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 484.56781 | 0.9947 | -1.016 | -0.9125 | -0.8965 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.6040 | -0.8026 | -0.8774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9219 | -0.7925 | -0.8127 | -0.8032 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.56781 | 92.51 | -5.316 | -0.9411 | -0.1121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.358 | 0.03133 | 0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 1.305 | 1.129 | 1.143 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.56781</span> | 92.51 | 0.004912 | 0.2807 | 0.8939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.952 | 1.358 | 0.03133 | 0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 1.305 | 1.129 | 1.143 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -42.28 | 1.959 | 0.05438 | 0.2483 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1829 | -28.95 | -10.12 | -0.04344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.379 | -8.677 | -6.653 | -7.817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 484.00832 | 1.000 | -1.018 | -0.9128 | -0.8970 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.5915 | -0.7988 | -0.8764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9214 | -0.7852 | -0.8076 | -0.7966 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.00832 | 93.05 | -5.318 | -0.9414 | -0.1125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.297 | 1.366 | 0.03139 | 0.7601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 1.314 | 1.135 | 1.150 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.00832</span> | 93.05 | 0.004901 | 0.2806 | 0.8936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.947 | 1.366 | 0.03139 | 0.7601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 1.314 | 1.135 | 1.150 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.54 | 2.001 | 0.2786 | 0.3182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4381 | -28.02 | -9.026 | -0.09975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.146 | -8.496 | -6.417 | -7.602 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 483.48726 | 0.9952 | -1.021 | -0.9132 | -0.8975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5798 | -0.7955 | -0.8750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9256 | -0.7775 | -0.8025 | -0.7898 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.48726 | 92.55 | -5.321 | -0.9418 | -0.1131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.296 | 1.373 | 0.03144 | 0.7611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8309 | 1.323 | 1.140 | 1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.48726</span> | 92.55 | 0.004889 | 0.2805 | 0.8931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.939 | 1.373 | 0.03144 | 0.7611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8309 | 1.323 | 1.140 | 1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -37.52 | 1.926 | 0.07054 | 0.2526 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2102 | -26.43 | -9.184 | -0.1123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.591 | -8.057 | -6.119 | -7.239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 482.99669 | 1.001 | -1.023 | -0.9136 | -0.8980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5700 | -0.7928 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9342 | -0.7702 | -0.7978 | -0.7834 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.99669 | 93.05 | -5.323 | -0.9422 | -0.1136 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.296 | 1.379 | 0.03148 | 0.7623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 1.332 | 1.145 | 1.164 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.99669</span> | 93.05 | 0.004876 | 0.2805 | 0.8926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.932 | 1.379 | 0.03148 | 0.7623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 1.332 | 1.145 | 1.164 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 33.56 | 1.934 | 0.3091 | 0.3219 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4700 | -25.85 | -8.255 | -0.09267 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.467 | -7.833 | -5.883 | -7.031 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 482.53338 | 0.9957 | -1.027 | -0.9143 | -0.8987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8507 | -0.5600 | -0.7904 | -0.8719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9423 | -0.7626 | -0.7931 | -0.7767 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.53338 | 92.60 | -5.327 | -0.9428 | -0.1143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.295 | 1.385 | 0.03152 | 0.7635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8163 | 1.342 | 1.150 | 1.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.53338</span> | 92.60 | 0.004861 | 0.2803 | 0.8920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.921 | 1.385 | 0.03152 | 0.7635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8163 | 1.342 | 1.150 | 1.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.71 | 1.852 | 0.1405 | 0.2615 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2476 | -24.53 | -8.462 | -0.2274 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.657 | -7.455 | -5.599 | -6.689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 482.07760 | 1.001 | -1.030 | -0.9154 | -0.8996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8522 | -0.5495 | -0.7881 | -0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9481 | -0.7546 | -0.7885 | -0.7696 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.0776 | 93.06 | -5.330 | -0.9439 | -0.1152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.293 | 1.391 | 0.03155 | 0.7654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8112 | 1.351 | 1.155 | 1.179 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.0776</span> | 93.06 | 0.004842 | 0.2801 | 0.8912 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.906 | 1.391 | 0.03155 | 0.7654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8112 | 1.351 | 1.155 | 1.179 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 31.51 | 1.862 | 0.3171 | 0.3253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4890 | -23.74 | -7.570 | -0.1627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | -7.176 | -5.365 | -6.441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 481.65018 | 0.9960 | -1.035 | -0.9168 | -0.9007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8541 | -0.5386 | -0.7859 | -0.8662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9515 | -0.7465 | -0.7840 | -0.7624 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.65018 | 92.63 | -5.335 | -0.9452 | -0.1163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | 1.398 | 0.03158 | 0.7678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8082 | 1.361 | 1.160 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.65018</span> | 92.63 | 0.004820 | 0.2799 | 0.8902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.887 | 1.398 | 0.03158 | 0.7678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8082 | 1.361 | 1.160 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.18 | 1.794 | 0.1244 | 0.2518 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2479 | -22.54 | -7.736 | -0.2537 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.155 | -6.794 | -5.094 | -6.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 481.23911 | 1.000 | -1.041 | -0.9182 | -0.9020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8564 | -0.5274 | -0.7840 | -0.8624 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9539 | -0.7386 | -0.7800 | -0.7556 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.23911 | 93.04 | -5.341 | -0.9465 | -0.1176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.289 | 1.404 | 0.03161 | 0.7707 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8061 | 1.371 | 1.164 | 1.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.23911</span> | 93.04 | 0.004792 | 0.2796 | 0.8890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.865 | 1.404 | 0.03161 | 0.7707 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8061 | 1.371 | 1.164 | 1.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 480.84332 | 1.001 | -1.048 | -0.9201 | -0.9037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8593 | -0.5164 | -0.7829 | -0.8573 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.7293 | -0.7754 | -0.7475 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.84332 | 93.06 | -5.348 | -0.9483 | -0.1193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.286 | 1.411 | 0.03163 | 0.7746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8041 | 1.382 | 1.169 | 1.203 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.84332</span> | 93.06 | 0.004757 | 0.2792 | 0.8875 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.836 | 1.411 | 0.03163 | 0.7746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8041 | 1.382 | 1.169 | 1.203 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 479.47395 | 1.001 | -1.077 | -0.9274 | -0.9105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8708 | -0.4737 | -0.7785 | -0.8375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9655 | -0.6927 | -0.7575 | -0.7158 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.47395 | 93.12 | -5.377 | -0.9551 | -0.1261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.275 | 1.436 | 0.03170 | 0.7896 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7959 | 1.426 | 1.188 | 1.237 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.47395</span> | 93.12 | 0.004620 | 0.2779 | 0.8816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.723 | 1.436 | 0.03170 | 0.7896 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7959 | 1.426 | 1.188 | 1.237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 477.01144 | 1.003 | -1.162 | -0.9485 | -0.9300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9044 | -0.3493 | -0.7656 | -0.7799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9925 | -0.5865 | -0.7057 | -0.6237 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.01144 | 93.31 | -5.462 | -0.9750 | -0.1456 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.241 | 1.511 | 0.03189 | 0.8334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7723 | 1.555 | 1.243 | 1.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.01144</span> | 93.31 | 0.004245 | 0.2739 | 0.8645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.403 | 1.511 | 0.03189 | 0.8334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7723 | 1.555 | 1.243 | 1.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.38 | 1.353 | -0.3553 | -0.05530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.006768 | -8.661 | -2.325 | -0.1540 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.503 | -0.2811 | -0.6438 | -0.5229 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 477.99463 | 1.002 | -1.284 | -0.8933 | -0.9162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8846 | -0.1951 | -0.7385 | -0.7367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.093 | -0.7697 | -0.8046 | -0.7596 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.99463 | 93.20 | -5.584 | -0.9231 | -0.1318 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.261 | 1.604 | 0.03230 | 0.8662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6840 | 1.333 | 1.138 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.99463</span> | 93.20 | 0.003757 | 0.2843 | 0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.591 | 1.604 | 0.03230 | 0.8662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6840 | 1.333 | 1.138 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 476.67952 | 1.000 | -1.201 | -0.9310 | -0.9256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.3000 | -0.7569 | -0.7662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.6445 | -0.7370 | -0.6668 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.67952 | 93.04 | -5.501 | -0.9585 | -0.1412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.541 | 0.03202 | 0.8438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7442 | 1.485 | 1.210 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.67952</span> | 93.04 | 0.004084 | 0.2772 | 0.8683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.541 | 0.03202 | 0.8438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7442 | 1.485 | 1.210 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.308 | 1.138 | 0.3206 | 0.007327 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.005220 | -6.420 | -1.952 | -0.8085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4295 | -3.531 | -2.349 | -2.485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 477.00015 | 0.9939 | -1.268 | -0.9234 | -0.9152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8823 | -0.2647 | -0.7585 | -0.7168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9725 | -0.6365 | -0.7310 | -0.6853 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.00015 | 92.43 | -5.568 | -0.9514 | -0.1308 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.263 | 1.562 | 0.03200 | 0.8813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 1.495 | 1.216 | 1.269 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.00015</span> | 92.43 | 0.003818 | 0.2786 | 0.8774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.613 | 1.562 | 0.03200 | 0.8813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 1.495 | 1.216 | 1.269 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 476.87328 | 0.9941 | -1.216 | -0.9300 | -0.9236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8950 | -0.2832 | -0.7542 | -0.7554 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -0.6375 | -0.7322 | -0.6666 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.87328 | 92.45 | -5.516 | -0.9576 | -0.1392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.551 | 0.03206 | 0.8520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7536 | 1.493 | 1.215 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.87328</span> | 92.45 | 0.004024 | 0.2774 | 0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.491 | 1.551 | 0.03206 | 0.8520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7536 | 1.493 | 1.215 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 476.68202 | 0.9977 | -1.202 | -0.9313 | -0.9256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.2947 | -0.7553 | -0.7655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6416 | -0.7351 | -0.6648 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.68202 | 92.79 | -5.502 | -0.9588 | -0.1412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.544 | 0.03204 | 0.8443 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7445 | 1.488 | 1.212 | 1.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.68202</span> | 92.79 | 0.004080 | 0.2771 | 0.8683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.544 | 0.03204 | 0.8443 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7445 | 1.488 | 1.212 | 1.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 476.66620 | 0.9991 | -1.201 | -0.9311 | -0.9256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.2974 | -0.7561 | -0.7659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6431 | -0.7361 | -0.6658 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.6662 | 92.92 | -5.501 | -0.9587 | -0.1412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.542 | 0.03203 | 0.8441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7443 | 1.487 | 1.211 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.6662</span> | 92.92 | 0.004082 | 0.2771 | 0.8683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.542 | 0.03203 | 0.8441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7443 | 1.487 | 1.211 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.67 | 1.127 | 0.2138 | -0.01630 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1134 | -4.869 | -1.703 | -0.03057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03000 | -2.848 | -2.302 | -2.432 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 476.65034 | 1.001 | -1.204 | -0.9308 | -0.9253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -0.2967 | -0.7561 | -0.7660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6432 | -0.7350 | -0.6655 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.65034 | 93.06 | -5.504 | -0.9584 | -0.1409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.248 | 1.543 | 0.03203 | 0.8440 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7448 | 1.487 | 1.212 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.65034</span> | 93.06 | 0.004070 | 0.2772 | 0.8686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.468 | 1.543 | 0.03203 | 0.8440 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7448 | 1.487 | 1.212 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.111 | 1.131 | 0.3498 | 0.02199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03596 | -6.336 | -1.893 | -0.8646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4089 | -3.511 | -2.253 | -2.437 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 476.63921 | 0.9998 | -1.207 | -0.9306 | -0.9249 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8968 | -0.2957 | -0.7561 | -0.7661 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6430 | -0.7338 | -0.6650 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.63921 | 92.98 | -5.507 | -0.9581 | -0.1405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.543 | 0.03203 | 0.8439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.487 | 1.213 | 1.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.63921</span> | 92.98 | 0.004058 | 0.2773 | 0.8689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.474 | 1.543 | 0.03203 | 0.8439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.487 | 1.213 | 1.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.837 | 1.116 | 0.2875 | 0.01149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02542 | -4.741 | -1.572 | 0.01643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.427 | -2.805 | -2.162 | -2.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 476.63321 | 1.001 | -1.209 | -0.9304 | -0.9247 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8965 | -0.2943 | -0.7557 | -0.7669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.6432 | -0.7330 | -0.6644 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.63321 | 93.07 | -5.509 | -0.9580 | -0.1403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.544 | 0.03204 | 0.8433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7468 | 1.487 | 1.214 | 1.292 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.63321</span> | 93.07 | 0.004050 | 0.2773 | 0.8691 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.477 | 1.544 | 0.03204 | 0.8433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7468 | 1.487 | 1.214 | 1.292 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.780 | 1.119 | 0.3715 | 0.03544 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06786 | -4.773 | -1.470 | -0.02124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.265 | -2.850 | -2.132 | -2.390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 476.62737 | 0.9998 | -1.211 | -0.9303 | -0.9246 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8963 | -0.2932 | -0.7554 | -0.7683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.6436 | -0.7322 | -0.6637 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.62737 | 92.98 | -5.511 | -0.9578 | -0.1402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.545 | 0.03204 | 0.8422 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.486 | 1.215 | 1.292 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.62737</span> | 92.98 | 0.004043 | 0.2773 | 0.8692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.479 | 1.545 | 0.03204 | 0.8422 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.486 | 1.215 | 1.292 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.468 | 1.108 | 0.2964 | 0.01787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01029 | -4.584 | -1.512 | -0.04750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.233 | -2.839 | -2.097 | -2.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 476.62183 | 1.001 | -1.213 | -0.9301 | -0.9245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8960 | -0.2918 | -0.7549 | -0.7696 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -0.6438 | -0.7313 | -0.6628 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.62183 | 93.07 | -5.513 | -0.9577 | -0.1401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.546 | 0.03205 | 0.8412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 1.486 | 1.216 | 1.293 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.62183</span> | 93.07 | 0.004035 | 0.2773 | 0.8693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.481 | 1.546 | 0.03205 | 0.8412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 1.486 | 1.216 | 1.293 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.726 | 1.111 | 0.3721 | 0.03969 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07339 | -4.588 | -1.391 | -0.04583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.059 | -2.851 | -2.052 | -2.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 476.61645 | 0.9998 | -1.215 | -0.9300 | -0.9243 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8958 | -0.2908 | -0.7546 | -0.7711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -0.6442 | -0.7306 | -0.6621 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.61645 | 92.98 | -5.515 | -0.9576 | -0.1399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.546 | 0.03205 | 0.8401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7517 | 1.485 | 1.217 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.61645</span> | 92.98 | 0.004027 | 0.2774 | 0.8694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.484 | 1.546 | 0.03205 | 0.8401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7517 | 1.485 | 1.217 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.224 | 1.099 | 0.2980 | 0.02349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.002638 | -4.438 | -1.447 | -0.09166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4490 | -2.896 | -2.021 | -2.267 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 476.60491 | 1.001 | -1.217 | -0.9300 | -0.9242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8956 | -0.2899 | -0.7543 | -0.7729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -0.6437 | -0.7294 | -0.6608 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.60491 | 93.08 | -5.517 | -0.9576 | -0.1398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 1.486 | 1.218 | 1.295 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.60491</span> | 93.08 | 0.004018 | 0.2774 | 0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.485 | 1.547 | 0.03206 | 0.8387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 1.486 | 1.218 | 1.295 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.891 | 1.101 | 0.3805 | 0.04781 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09121 | -4.602 | -1.355 | -0.1211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9908 | -2.875 | -1.954 | -2.212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 476.59275 | 0.9999 | -1.219 | -0.9301 | -0.9241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8954 | -0.2896 | -0.7542 | -0.7748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.6434 | -0.7284 | -0.6597 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.59275 | 92.99 | -5.519 | -0.9576 | -0.1397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7512 | 1.486 | 1.219 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.59275</span> | 92.99 | 0.004009 | 0.2774 | 0.8696 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.487 | 1.547 | 0.03206 | 0.8373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7512 | 1.486 | 1.219 | 1.297 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.741 | 1.086 | 0.3018 | 0.02978 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01334 | -4.300 | -1.393 | -0.08082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4335 | -2.821 | -1.884 | -2.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 476.58049 | 1.001 | -1.222 | -0.9302 | -0.9241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8953 | -0.2889 | -0.7541 | -0.7767 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.6427 | -0.7275 | -0.6585 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.58049 | 93.06 | -5.522 | -0.9577 | -0.1397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7507 | 1.487 | 1.220 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.58049</span> | 93.06 | 0.003999 | 0.2773 | 0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.488 | 1.547 | 0.03206 | 0.8359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7507 | 1.487 | 1.220 | 1.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 476.57085 | 1.001 | -1.225 | -0.9302 | -0.9239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8951 | -0.2891 | -0.7542 | -0.7796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -0.6424 | -0.7265 | -0.6573 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.57085 | 93.06 | -5.525 | -0.9578 | -0.1395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7502 | 1.488 | 1.221 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.57085</span> | 93.06 | 0.003985 | 0.2773 | 0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.490 | 1.547 | 0.03206 | 0.8336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7502 | 1.488 | 1.221 | 1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 476.52700 | 1.000 | -1.243 | -0.9306 | -0.9233 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.2898 | -0.7549 | -0.7948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.6409 | -0.7216 | -0.6509 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.527 | 93.02 | -5.543 | -0.9582 | -0.1389 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.251 | 1.547 | 0.03205 | 0.8221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7475 | 1.489 | 1.226 | 1.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.527</span> | 93.02 | 0.003915 | 0.2772 | 0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.501 | 1.547 | 0.03205 | 0.8221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7475 | 1.489 | 1.226 | 1.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 476.45166 | 0.9988 | -1.314 | -0.9321 | -0.9209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8895 | -0.2927 | -0.7576 | -0.8554 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.033 | -0.6351 | -0.7022 | -0.6254 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.45166 | 92.89 | -5.614 | -0.9596 | -0.1365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.256 | 1.545 | 0.03201 | 0.7760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7365 | 1.496 | 1.247 | 1.333 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.45166</span> | 92.89 | 0.003648 | 0.2770 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.543 | 1.545 | 0.03201 | 0.7760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7365 | 1.496 | 1.247 | 1.333 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -21.31 | 0.8191 | 0.2022 | 0.1018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1327 | -4.505 | -1.303 | -1.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.080 | -2.304 | -0.3706 | -0.4948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 476.56836 | 1.004 | -1.424 | -0.9336 | -0.9183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8856 | -0.2810 | -0.7637 | -0.9206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.6303 | -0.6962 | -0.6148 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.56836 | 93.36 | -5.724 | -0.9609 | -0.1338 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.260 | 1.552 | 0.03192 | 0.7265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 1.502 | 1.254 | 1.345 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.56836</span> | 93.36 | 0.003266 | 0.2767 | 0.8747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.581 | 1.552 | 0.03192 | 0.7265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 1.502 | 1.254 | 1.345 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 476.44457 | 1.002 | -1.351 | -0.9326 | -0.9200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8882 | -0.2885 | -0.7595 | -0.8773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6333 | -0.7001 | -0.6218 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.44457 | 93.15 | -5.651 | -0.9600 | -0.1356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.257 | 1.548 | 0.03198 | 0.7594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.499 | 1.249 | 1.337 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.44457</span> | 93.15 | 0.003514 | 0.2769 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.556 | 1.548 | 0.03198 | 0.7594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.499 | 1.249 | 1.337 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.82 | 0.7276 | 0.3571 | 0.1746 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4004 | -4.436 | -0.9222 | -1.572 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.287 | -2.164 | -0.2873 | -0.3883 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 476.40417 | 1.000 | -1.371 | -0.9349 | -0.9209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8904 | -0.2869 | -0.7634 | -0.8782 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6262 | -0.7046 | -0.6250 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.40417 | 93.02 | -5.671 | -0.9622 | -0.1365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.255 | 1.549 | 0.03192 | 0.7587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7444 | 1.507 | 1.245 | 1.334 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.40417</span> | 93.02 | 0.003446 | 0.2764 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.535 | 1.549 | 0.03192 | 0.7587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7444 | 1.507 | 1.245 | 1.334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 476.37918 | 1.000 | -1.391 | -0.9372 | -0.9218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8927 | -0.2856 | -0.7675 | -0.8792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.6191 | -0.7092 | -0.6283 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.37918 | 93.03 | -5.691 | -0.9644 | -0.1374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.253 | 1.549 | 0.03186 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7434 | 1.516 | 1.240 | 1.330 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.37918</span> | 93.03 | 0.003376 | 0.2760 | 0.8716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.513 | 1.549 | 0.03186 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7434 | 1.516 | 1.240 | 1.330 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 476.33357 | 1.001 | -1.461 | -0.9453 | -0.9249 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.2814 | -0.7818 | -0.8827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5944 | -0.7253 | -0.6399 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.33357 | 93.07 | -5.761 | -0.9719 | -0.1405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.245 | 1.552 | 0.03165 | 0.7553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7403 | 1.546 | 1.222 | 1.318 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.33357</span> | 93.07 | 0.003146 | 0.2745 | 0.8689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.440 | 1.552 | 0.03165 | 0.7553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7403 | 1.546 | 1.222 | 1.318 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.553 | 0.4475 | -0.2195 | 0.07220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05655 | -4.350 | -1.061 | -1.750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1436 | -0.4527 | -1.673 | -1.245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 476.20746 | 1.002 | -1.571 | -0.9452 | -0.9313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9123 | -0.2680 | -0.8139 | -0.8382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.032 | -0.6009 | -0.7081 | -0.6381 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.20746 | 93.20 | -5.871 | -0.9719 | -0.1469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.233 | 1.560 | 0.03117 | 0.7891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7373 | 1.538 | 1.241 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.20746</span> | 93.20 | 0.002821 | 0.2745 | 0.8634 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.328 | 1.560 | 0.03117 | 0.7891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7373 | 1.538 | 1.241 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.15 | 0.1791 | -0.01894 | -0.004675 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06593 | -5.850 | -1.512 | -1.794 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.396 | -1.647 | -0.7085 | -1.309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 476.15444 | 1.000 | -1.669 | -0.9317 | -0.9229 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | -0.2480 | -0.8424 | -0.7961 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.6117 | -0.7275 | -0.5959 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.15444 | 93.03 | -5.969 | -0.9591 | -0.1385 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.256 | 1.572 | 0.03074 | 0.8211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.525 | 1.220 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.15444</span> | 93.03 | 0.002558 | 0.2771 | 0.8707 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.549 | 1.572 | 0.03074 | 0.8211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.525 | 1.220 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.97 | -0.09883 | 0.5245 | 0.1410 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5845 | -3.407 | -1.272 | -0.2800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9652 | -1.487 | -1.684 | 0.3572 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 476.18235 | 1.000 | -1.690 | -0.9781 | -0.8961 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8818 | -0.1915 | -0.8548 | -0.7635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.6068 | -0.6702 | -0.6625 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.18235 | 93.04 | -5.990 | -1.003 | -0.1117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.264 | 1.606 | 0.03055 | 0.8458 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.531 | 1.281 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.18235</span> | 93.04 | 0.002505 | 0.2684 | 0.8943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.617 | 1.606 | 0.03055 | 0.8458 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.531 | 1.281 | 1.294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 476.08231 | 1.003 | -1.678 | -0.9530 | -0.9107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8858 | -0.2215 | -0.8479 | -0.7811 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -0.6092 | -0.7010 | -0.6265 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.08231 | 93.25 | -5.978 | -0.9792 | -0.1263 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.260 | 1.588 | 0.03066 | 0.8325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7350 | 1.528 | 1.248 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.08231</span> | 93.25 | 0.002533 | 0.2730 | 0.8814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.579 | 1.588 | 0.03066 | 0.8325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7350 | 1.528 | 1.248 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.25 | -0.08933 | -0.2508 | 0.5157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8830 | -3.835 | -1.133 | -1.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -2.153 | -0.2439 | -1.007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 476.03808 | 1.001 | -1.672 | -0.9320 | -0.9310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9291 | -0.2079 | -0.8419 | -0.7733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.039 | -0.6026 | -0.6913 | -0.6380 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.03808 | 93.13 | -5.972 | -0.9594 | -0.1466 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.216 | 1.596 | 0.03074 | 0.8384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7314 | 1.536 | 1.259 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.03808</span> | 93.13 | 0.002548 | 0.2770 | 0.8636 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.173 | 1.596 | 0.03074 | 0.8384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7314 | 1.536 | 1.259 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.407 | -0.06545 | 0.6727 | 0.05373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4541 | -1.330 | -0.5709 | -0.1224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8702 | -1.228 | 0.2640 | -1.506 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 476.03300 | 1.003 | -1.664 | -0.9621 | -0.9598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9520 | -0.2020 | -0.8337 | -0.7650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.042 | -0.6106 | -0.7076 | -0.6154 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.033 | 93.29 | -5.964 | -0.9878 | -0.1754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.193 | 1.599 | 0.03087 | 0.8447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7289 | 1.526 | 1.241 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.033</span> | 93.29 | 0.002569 | 0.2714 | 0.8391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.966 | 1.599 | 0.03087 | 0.8447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7289 | 1.526 | 1.241 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.25 | -0.008049 | -0.5780 | -0.5632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9601 | -0.9870 | -0.1614 | -0.08306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3446 | -1.564 | -0.5735 | -0.5777 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 475.98457 | 1.001 | -1.657 | -0.9620 | -0.9650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9284 | -0.2016 | -0.8312 | -0.7567 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -0.6004 | -0.7091 | -0.6133 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.98457 | 93.13 | -5.957 | -0.9877 | -0.1806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 1.600 | 0.03091 | 0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7262 | 1.538 | 1.240 | 1.346 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.98457</span> | 93.13 | 0.002588 | 0.2714 | 0.8347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.180 | 1.600 | 0.03091 | 0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7262 | 1.538 | 1.240 | 1.346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 475.96536 | 1.003 | -1.649 | -0.9620 | -0.9705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9043 | -0.2014 | -0.8286 | -0.7480 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.048 | -0.5903 | -0.7109 | -0.6113 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.96536 | 93.24 | -5.949 | -0.9876 | -0.1861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.241 | 1.600 | 0.03094 | 0.8576 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7235 | 1.551 | 1.238 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.96536</span> | 93.24 | 0.002608 | 0.2714 | 0.8302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.403 | 1.600 | 0.03094 | 0.8576 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7235 | 1.551 | 1.238 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 476.05821 | 1.003 | -1.627 | -0.9618 | -0.9866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8332 | -0.2007 | -0.8211 | -0.7226 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.057 | -0.5602 | -0.7159 | -0.6052 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.05821 | 93.28 | -5.927 | -0.9874 | -0.2022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.312 | 1.600 | 0.03106 | 0.8769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7156 | 1.587 | 1.233 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.05821</span> | 93.28 | 0.002666 | 0.2714 | 0.8169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 10.10 | 1.600 | 0.03106 | 0.8769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7156 | 1.587 | 1.233 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.90 | 0.05098 | -0.6601 | -0.8657 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4347 | -0.9523 | -0.3178 | -0.1283 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1024 | -0.7800 | -0.7284 | -0.4981 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 476.00714 | 1.001 | -1.643 | -0.9512 | -0.8390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8932 | -0.2051 | -0.7956 | -0.7365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -0.5599 | -0.7127 | -0.5744 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.00714 | 93.11 | -5.943 | -0.9775 | -0.05460 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.252 | 1.598 | 0.03144 | 0.8663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7264 | 1.588 | 1.236 | 1.388 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.00714</span> | 93.11 | 0.002624 | 0.2734 | 0.9469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.508 | 1.598 | 0.03144 | 0.8663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7264 | 1.588 | 1.236 | 1.388 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 475.93814 | 1.000 | -1.647 | -0.9575 | -0.9171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8999 | -0.2027 | -0.8152 | -0.7434 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.047 | -0.5779 | -0.7115 | -0.5963 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.93814 | 93.01 | -5.947 | -0.9834 | -0.1327 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.245 | 1.599 | 0.03115 | 0.8612 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7247 | 1.566 | 1.237 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.93814</span> | 93.01 | 0.002614 | 0.2722 | 0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.445 | 1.599 | 0.03115 | 0.8612 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7247 | 1.566 | 1.237 | 1.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -23.67 | 0.03897 | -0.7058 | 0.2979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2507 | -0.5051 | -0.4675 | -0.05050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.329 | -0.1594 | -0.7628 | 0.1885 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 475.98668 | 1.003 | -1.653 | -0.9119 | -0.8938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.2050 | -0.7980 | -0.7479 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.040 | -0.5617 | -0.7056 | -0.5853 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.98668 | 93.26 | -5.953 | -0.9406 | -0.1094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.251 | 1.598 | 0.03140 | 0.8577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7310 | 1.586 | 1.243 | 1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.98668</span> | 93.26 | 0.002598 | 0.2808 | 0.8964 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.501 | 1.598 | 0.03140 | 0.8577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7310 | 1.586 | 1.243 | 1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 475.93401 | 1.003 | -1.649 | -0.9419 | -0.9092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8979 | -0.2035 | -0.8093 | -0.7449 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.044 | -0.5723 | -0.7094 | -0.5925 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.93401 | 93.26 | -5.949 | -0.9687 | -0.1248 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.599 | 0.03123 | 0.8600 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7270 | 1.573 | 1.239 | 1.369 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.93401</span> | 93.26 | 0.002609 | 0.2751 | 0.8827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.464 | 1.599 | 0.03123 | 0.8600 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7270 | 1.573 | 1.239 | 1.369 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.62 | 0.03755 | 0.3553 | 0.5344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5780 | -0.8226 | -0.2181 | -0.2167 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.049 | 0.002537 | -0.7279 | 0.2347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 475.92580 | 1.001 | -1.653 | -0.9417 | -0.9124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8966 | -0.2037 | -0.8058 | -0.7501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.5739 | -0.7048 | -0.5926 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.9258 | 93.12 | -5.953 | -0.9686 | -0.1280 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.598 | 0.03129 | 0.8560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7297 | 1.571 | 1.244 | 1.369 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.9258</span> | 93.12 | 0.002598 | 0.2752 | 0.8798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.476 | 1.598 | 0.03129 | 0.8560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7297 | 1.571 | 1.244 | 1.369 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.238 | 0.003180 | 0.2025 | 0.4289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4493 | -0.2935 | -0.2270 | -0.1209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3327 | -0.04065 | -0.4864 | 0.2705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 475.92421 | 1.002 | -1.655 | -0.9475 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8971 | -0.2051 | -0.8017 | -0.7499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.5760 | -0.7024 | -0.5951 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.92421 | 93.14 | -5.955 | -0.9740 | -0.1336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.248 | 1.598 | 0.03135 | 0.8562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.568 | 1.247 | 1.366 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.92421</span> | 93.14 | 0.002593 | 0.2741 | 0.8749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.472 | 1.598 | 0.03135 | 0.8562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.568 | 1.247 | 1.366 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.572 | 0.0005078 | -0.07939 | 0.3039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4520 | -0.5123 | -0.2298 | -0.1955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3506 | -0.1759 | -0.3471 | 0.1717 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 475.91356 | 1.001 | -1.654 | -0.9476 | -0.9223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8992 | -0.2071 | -0.7965 | -0.7440 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.043 | -0.5749 | -0.7035 | -0.5974 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.91356 | 93.12 | -5.954 | -0.9741 | -0.1379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.246 | 1.596 | 0.03143 | 0.8607 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7278 | 1.569 | 1.246 | 1.363 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.91356</span> | 93.12 | 0.002596 | 0.2741 | 0.8712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.452 | 1.596 | 0.03143 | 0.8607 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7278 | 1.569 | 1.246 | 1.363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 475.89054 | 1.001 | -1.650 | -0.9479 | -0.9349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9054 | -0.2136 | -0.7808 | -0.7261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.051 | -0.5716 | -0.7071 | -0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.89054 | 93.11 | -5.950 | -0.9744 | -0.1505 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.240 | 1.592 | 0.03166 | 0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.89054</span> | 93.11 | 0.002606 | 0.2740 | 0.8602 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.393 | 1.592 | 0.03166 | 0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.467 | 0.05330 | -0.1133 | -0.1045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1362 | -0.3304 | -0.2172 | 0.04726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.416 | 0.08323 | -0.4566 | -0.2851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 476.06529 | 1.002 | -1.688 | -0.8959 | -0.9784 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9076 | -0.2354 | -0.6823 | -0.7302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -0.5603 | -0.6700 | -0.6079 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.06529 | 93.20 | -5.988 | -0.9255 | -0.1940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.238 | 1.579 | 0.03314 | 0.8712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7347 | 1.587 | 1.281 | 1.352 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.06529</span> | 93.20 | 0.002510 | 0.2838 | 0.8236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.372 | 1.579 | 0.03314 | 0.8712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7347 | 1.587 | 1.281 | 1.352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 475.89054 | 1.001 | -1.650 | -0.9479 | -0.9349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9054 | -0.2136 | -0.7808 | -0.7261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.051 | -0.5716 | -0.7071 | -0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.89054 | 93.11 | -5.950 | -0.9744 | -0.1505 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.240 | 1.592 | 0.03166 | 0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.89054</span> | 93.11 | 0.002606 | 0.2740 | 0.8602 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.393 | 1.592 | 0.03166 | 0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma_low | rsd_high |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 495.48573 | 1.000 | -1.000 | -0.9104 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9875 | -0.8823 | -0.8746 | -0.8907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8767 | -0.8731 | -0.8673 | -0.8720 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8739 | -0.8666 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.48573 | 91.00 | -5.200 | -0.8900 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4600 | 0.8300 | 0.05800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7311 | 0.9036 | 1.183 | 0.9554 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.48573</span> | 91.00 | 0.005517 | 0.2911 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01005 | 0.6130 | 0.8300 | 0.05800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7311 | 0.9036 | 1.183 | 0.9554 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -0.9650 | 2.223 | -0.3153 | -0.01817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3350 | 0.6789 | -29.17 | -19.58 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9642 | 9.851 | -11.94 | -1.319 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 8.578 | -12.45 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 487.27153 | 1.023 | -1.054 | -0.9028 | -0.9372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9794 | -0.8987 | -0.1695 | -0.4175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9000 | -1.111 | -0.5788 | -0.8401 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.081 | -0.5657 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.27153 | 93.12 | -5.254 | -0.8832 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4525 | 1.123 | 0.07172 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6884 | 1.525 | 0.9859 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6843 | 1.580 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.27153</span> | 93.12 | 0.005228 | 0.2925 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.123 | 0.07172 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6884 | 1.525 | 0.9859 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6843 | 1.580 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 131.2 | 1.375 | 2.844 | -0.2311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2724 | 0.4206 | 9.234 | 14.82 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3432 | -1.547 | -2.137 | 2.699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.845 | -6.389 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 3806.3530 | 0.1967 | -1.082 | -0.9181 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9782 | -0.9073 | 0.02635 | -0.3409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9062 | -1.204 | -0.4610 | -0.8458 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.125 | -0.4164 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 3806.353 | 17.90 | -5.282 | -0.8969 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4485 | 1.204 | 0.07394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7095 | 0.6043 | 1.664 | 0.9805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6463 | 1.761 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 3806.353</span> | 17.90 | 0.005083 | 0.2897 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01015 | 0.6103 | 1.204 | 0.07394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7095 | 0.6043 | 1.664 | 0.9805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6463 | 1.761 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 498.29847 | 0.9363 | -1.055 | -0.9047 | -0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9796 | -0.8990 | -0.1756 | -0.4273 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8998 | -1.110 | -0.5773 | -0.8419 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.078 | -0.5615 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 498.29847 | 85.20 | -5.255 | -0.8849 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4523 | 1.120 | 0.07144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7142 | 0.6894 | 1.526 | 0.9842 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6871 | 1.585 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 498.29847</span> | 85.20 | 0.005223 | 0.2922 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.120 | 0.07144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7142 | 0.6894 | 1.526 | 0.9842 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6871 | 1.585 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 485.66266 | 1.001 | -1.054 | -0.9033 | -0.9372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -0.8988 | -0.1711 | -0.4200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8999 | -1.111 | -0.5784 | -0.8406 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.080 | -0.5646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.66266 | 91.08 | -5.254 | -0.8836 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4524 | 1.122 | 0.07165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6887 | 1.525 | 0.9855 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6850 | 1.581 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.66266</span> | 91.08 | 0.005227 | 0.2924 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.122 | 0.07165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6887 | 1.525 | 0.9855 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6850 | 1.581 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.221 | 1.276 | 0.8286 | 0.07146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3378 | 0.6177 | 8.950 | 14.42 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.232 | -2.934 | -2.090 | 2.822 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.031 | -6.085 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 485.32609 | 0.9950 | -1.055 | -0.9042 | -0.9372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9799 | -0.8995 | -0.1813 | -0.4364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -1.108 | -0.5760 | -0.8438 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.076 | -0.5577 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.32609 | 90.54 | -5.255 | -0.8845 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4521 | 1.118 | 0.07117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7160 | 0.6917 | 1.528 | 0.9824 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6890 | 1.589 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.32609</span> | 90.54 | 0.005219 | 0.2922 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6111 | 1.118 | 0.07117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7160 | 0.6917 | 1.528 | 0.9824 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6890 | 1.589 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.72 | 1.256 | 0.2407 | 0.1468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3576 | 0.6982 | 8.550 | 13.79 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.152 | -3.092 | -1.869 | 2.672 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.399 | -5.827 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 484.94767 | 1.003 | -1.055 | -0.9045 | -0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9801 | -0.8996 | -0.1956 | -0.4497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8963 | -1.103 | -0.5795 | -0.8455 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.071 | -0.5595 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.94767 | 91.28 | -5.255 | -0.8848 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4521 | 1.112 | 0.07079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 0.6961 | 1.524 | 0.9808 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6930 | 1.587 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.94767</span> | 91.28 | 0.005220 | 0.2922 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6111 | 1.112 | 0.07079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 0.6961 | 1.524 | 0.9808 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6930 | 1.587 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.95 | 1.308 | 0.9181 | 0.03760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3308 | 0.6549 | 8.124 | 13.74 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.975 | -2.369 | -2.107 | 2.437 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.334 | -5.928 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 484.63747 | 0.9965 | -1.055 | -0.9051 | -0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9805 | -0.8998 | -0.2100 | -0.4642 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8952 | -1.098 | -0.5823 | -0.8472 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.5602 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.63747 | 90.68 | -5.255 | -0.8853 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4520 | 1.106 | 0.07037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7176 | 0.7002 | 1.521 | 0.9792 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.586 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.63747</span> | 90.68 | 0.005220 | 0.2921 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6111 | 1.106 | 0.07037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7176 | 0.7002 | 1.521 | 0.9792 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.586 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.67 | 1.288 | 0.2773 | 0.1211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3459 | 0.7203 | 8.028 | 13.24 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.967 | -2.555 | -2.117 | 2.333 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.789 | -5.812 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 484.31288 | 1.003 | -1.055 | -0.9054 | -0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9808 | -0.9000 | -0.2248 | -0.4783 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8942 | -1.094 | -0.5856 | -0.8486 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.063 | -0.5617 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.31288 | 91.27 | -5.255 | -0.8855 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4519 | 1.100 | 0.06996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7183 | 0.7043 | 1.517 | 0.9778 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7003 | 1.585 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.31288</span> | 91.27 | 0.005220 | 0.2920 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6111 | 1.100 | 0.06996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7183 | 0.7043 | 1.517 | 0.9778 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7003 | 1.585 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.32 | 1.333 | 0.8110 | 0.03416 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3225 | 0.6774 | 7.502 | 12.95 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.990 | -1.849 | -2.190 | 2.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.714 | -5.891 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 484.03445 | 0.9966 | -1.055 | -0.9058 | -0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9811 | -0.9003 | -0.2393 | -0.4932 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8929 | -1.090 | -0.5881 | -0.8501 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.059 | -0.5620 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.03445 | 90.69 | -5.255 | -0.8859 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4517 | 1.094 | 0.06953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7192 | 0.7079 | 1.514 | 0.9764 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7034 | 1.584 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.03445</span> | 90.69 | 0.005219 | 0.2919 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6110 | 1.094 | 0.06953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7192 | 0.7079 | 1.514 | 0.9764 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7034 | 1.584 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -23.34 | 1.311 | 0.1997 | 0.1136 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3397 | 0.7422 | 7.043 | 12.17 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.843 | -2.075 | -2.300 | 2.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.235 | -5.778 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 483.72794 | 1.003 | -1.056 | -0.9061 | -0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9815 | -0.9008 | -0.2540 | -0.5081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8918 | -1.086 | -0.5906 | -0.8514 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.5623 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.72794 | 91.28 | -5.256 | -0.8861 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4515 | 1.088 | 0.06909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7200 | 0.7113 | 1.511 | 0.9751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7061 | 1.584 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.72794</span> | 91.28 | 0.005217 | 0.2919 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6110 | 1.088 | 0.06909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7200 | 0.7113 | 1.511 | 0.9751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7061 | 1.584 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.56 | 1.355 | 0.7367 | 0.03002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3166 | 0.7021 | 6.528 | 11.89 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.880 | -1.512 | -2.404 | 1.917 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.215 | -5.846 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 483.44272 | 0.9974 | -1.057 | -0.9064 | -0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9820 | -0.9016 | -0.2678 | -0.5243 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8904 | -1.083 | -0.5914 | -0.8528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.054 | -0.5601 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.44272 | 90.76 | -5.257 | -0.8865 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4511 | 1.082 | 0.06862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7211 | 0.7141 | 1.510 | 0.9738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7081 | 1.587 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.44272</span> | 90.76 | 0.005212 | 0.2918 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6109 | 1.082 | 0.06862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7211 | 0.7141 | 1.510 | 0.9738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7081 | 1.587 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -19.50 | 1.332 | 0.2061 | 0.1022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3336 | 0.7519 | 5.944 | 11.09 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.878 | -1.675 | -2.404 | 1.054 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.833 | -5.715 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 483.13758 | 1.003 | -1.059 | -0.9067 | -0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9826 | -0.9029 | -0.2791 | -0.5415 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8881 | -1.081 | -0.5896 | -0.8508 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -0.5541 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.13758 | 91.30 | -5.259 | -0.8867 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.595 | 0.4505 | 1.077 | 0.06813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7227 | 0.7157 | 1.512 | 0.9758 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7089 | 1.594 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.13758</span> | 91.30 | 0.005202 | 0.2918 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01010 | 0.6108 | 1.077 | 0.06813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7227 | 0.7157 | 1.512 | 0.9758 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7089 | 1.594 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.83 | 1.368 | 0.7006 | 0.02276 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3159 | 0.7144 | 5.487 | 10.74 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.773 | -1.125 | -2.251 | 1.956 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.882 | -5.671 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 482.85180 | 0.9981 | -1.062 | -0.9072 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9834 | -0.9050 | -0.2850 | -0.5582 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8853 | -1.082 | -0.5852 | -0.8503 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -0.5428 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.8518 | 90.83 | -5.262 | -0.8872 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.596 | 0.4496 | 1.075 | 0.06764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7248 | 0.7152 | 1.517 | 0.9762 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7084 | 1.607 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.8518</span> | 90.83 | 0.005184 | 0.2917 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01009 | 0.6105 | 1.075 | 0.06764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7248 | 0.7152 | 1.517 | 0.9762 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7084 | 1.607 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.64 | 1.337 | 0.2421 | 0.09047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3389 | 0.7643 | 5.051 | 10.06 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.787 | -1.445 | -2.047 | 2.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.627 | -5.410 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 482.60290 | 1.003 | -1.066 | -0.9079 | -0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9844 | -0.9075 | -0.2858 | -0.5723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8822 | -1.083 | -0.5806 | -0.8571 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.055 | -0.5294 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.6029 | 91.28 | -5.266 | -0.8878 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.597 | 0.4484 | 1.074 | 0.06723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7271 | 0.7136 | 1.523 | 0.9697 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7072 | 1.624 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.6029</span> | 91.28 | 0.005162 | 0.2916 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01008 | 0.6103 | 1.074 | 0.06723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7271 | 0.7136 | 1.523 | 0.9697 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7072 | 1.624 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 14.50 | 1.352 | 0.6742 | 0.02192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3317 | 0.7297 | 4.803 | 9.894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.694 | -1.220 | -2.031 | 1.506 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.722 | -5.269 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 482.37953 | 0.9987 | -1.071 | -0.9090 | -0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9857 | -0.9106 | -0.2840 | -0.5862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8787 | -1.084 | -0.5758 | -0.8611 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.5150 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.37953 | 90.88 | -5.271 | -0.8888 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.598 | 0.4470 | 1.075 | 0.06683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7296 | 0.7132 | 1.528 | 0.9659 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7058 | 1.641 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.37953</span> | 90.88 | 0.005137 | 0.2914 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01007 | 0.6099 | 1.075 | 0.06683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7296 | 0.7132 | 1.528 | 0.9659 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7058 | 1.641 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 482.17662 | 0.9986 | -1.077 | -0.9102 | -0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9871 | -0.9141 | -0.2800 | -0.5994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8750 | -1.085 | -0.5707 | -0.8654 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.059 | -0.4996 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.17662 | 90.88 | -5.277 | -0.8898 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4454 | 1.077 | 0.06645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7323 | 0.7123 | 1.534 | 0.9618 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7037 | 1.660 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.17662</span> | 90.88 | 0.005108 | 0.2911 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01006 | 0.6095 | 1.077 | 0.06645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7323 | 0.7123 | 1.534 | 0.9618 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7037 | 1.660 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 481.54428 | 0.9984 | -1.097 | -0.9142 | -0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9921 | -0.9262 | -0.2660 | -0.6456 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8623 | -1.088 | -0.5530 | -0.8805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.068 | -0.4457 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.54428 | 90.86 | -5.297 | -0.8934 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.605 | 0.4398 | 1.083 | 0.06511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7417 | 0.7091 | 1.555 | 0.9473 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6961 | 1.725 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.54428</span> | 90.86 | 0.005009 | 0.2904 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01001 | 0.6082 | 1.083 | 0.06511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7417 | 0.7091 | 1.555 | 0.9473 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6961 | 1.725 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 480.42060 | 0.9980 | -1.149 | -0.9249 | -0.9384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9588 | -0.2285 | -0.7695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8280 | -1.098 | -0.5055 | -0.9211 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.091 | -0.3011 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.4206 | 90.81 | -5.349 | -0.9029 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4248 | 1.098 | 0.06151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.7005 | 1.611 | 0.9085 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6759 | 1.901 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.4206</span> | 90.81 | 0.004753 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009872 | 0.6046 | 1.098 | 0.06151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.7005 | 1.611 | 0.9085 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6759 | 1.901 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.54 | 1.160 | -0.4282 | 0.02550 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4248 | 0.7330 | 2.572 | 4.769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.047 | -1.982 | 1.244 | -3.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.792 | -2.494 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 480.52888 | 1.003 | -1.232 | -0.9300 | -0.9345 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.037 | -1.013 | -0.2660 | -0.9542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7770 | -1.021 | -0.6177 | -0.7306 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.035 | -0.1927 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.52888 | 91.28 | -5.432 | -0.9075 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.649 | 0.3997 | 1.083 | 0.05616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8040 | 0.7699 | 1.479 | 1.091 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7247 | 2.033 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.52888</span> | 91.28 | 0.004374 | 0.2875 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009571 | 0.5986 | 1.083 | 0.05616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8040 | 0.7699 | 1.479 | 1.091 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7247 | 2.033 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 479.69850 | 1.004 | -1.189 | -0.9273 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.9850 | -0.2467 | -0.8583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8035 | -1.061 | -0.5593 | -0.8297 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2490 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.6985 | 91.34 | -5.389 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4128 | 1.091 | 0.05894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7846 | 0.7338 | 1.548 | 0.9959 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.964 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.6985</span> | 91.34 | 0.004567 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009727 | 0.6018 | 1.091 | 0.05894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7846 | 0.7338 | 1.548 | 0.9959 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.964 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.264 | 1.163 | -0.05494 | -0.06753 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3641 | 0.6248 | 0.1998 | 1.877 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5696 | 0.3809 | 0.8989 | 3.758 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2123 | -1.578 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 479.87893 | 1.001 | -1.256 | -0.9150 | -0.9312 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -1.024 | -0.2268 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7799 | -1.052 | -0.6825 | -0.8629 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.2060 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.87893 | 91.06 | -5.456 | -0.8941 | -2.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.658 | 0.3949 | 1.099 | 0.05789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8019 | 0.7416 | 1.402 | 0.9642 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7063 | 2.016 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.87893</span> | 91.06 | 0.004269 | 0.2903 | 0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009490 | 0.5975 | 1.099 | 0.05789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8019 | 0.7416 | 1.402 | 0.9642 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7063 | 2.016 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 479.70356 | 0.9996 | -1.214 | -0.9229 | -0.9346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9992 | -0.2397 | -0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7947 | -1.058 | -0.6038 | -0.8437 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.061 | -0.2328 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.70356 | 90.96 | -5.414 | -0.9011 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4062 | 1.093 | 0.05853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7364 | 1.495 | 0.9825 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7017 | 1.984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.70356</span> | 90.96 | 0.004455 | 0.2888 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009639 | 0.6002 | 1.093 | 0.05853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7364 | 1.495 | 0.9825 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7017 | 1.984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 479.71523 | 0.9993 | -1.201 | -0.9253 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9918 | -0.2436 | -0.8656 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7992 | -1.060 | -0.5801 | -0.8379 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.063 | -0.2408 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.71523 | 90.93 | -5.401 | -0.9032 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4096 | 1.092 | 0.05873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7349 | 1.523 | 0.9880 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7004 | 1.974 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.71523</span> | 90.93 | 0.004513 | 0.2884 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009685 | 0.6010 | 1.092 | 0.05873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7349 | 1.523 | 0.9880 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7004 | 1.974 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 479.73471 | 0.9991 | -1.194 | -0.9266 | -0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9877 | -0.2457 | -0.8619 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8017 | -1.061 | -0.5670 | -0.8347 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2453 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.73471 | 90.92 | -5.394 | -0.9044 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4115 | 1.091 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7340 | 1.539 | 0.9911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6996 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.73471</span> | 90.92 | 0.004545 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009710 | 0.6015 | 1.091 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7340 | 1.539 | 0.9911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6996 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 479.71271 | 1.001 | -1.190 | -0.9273 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9854 | -0.2468 | -0.8594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8032 | -1.061 | -0.5599 | -0.8320 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2481 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.71271 | 91.05 | -5.390 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9937 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.71271</span> | 91.05 | 0.004564 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009725 | 0.6017 | 1.091 | 0.05891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9937 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 479.69386 | 1.003 | -1.189 | -0.9273 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.9851 | -0.2467 | -0.8587 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8034 | -1.061 | -0.5595 | -0.8305 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2487 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.69386 | 91.24 | -5.389 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4127 | 1.091 | 0.05893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7847 | 0.7338 | 1.548 | 0.9951 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.69386</span> | 91.24 | 0.004566 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009726 | 0.6017 | 1.091 | 0.05893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7847 | 0.7338 | 1.548 | 0.9951 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.722 | 1.155 | -0.1645 | -0.05121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3669 | 0.6376 | 0.06785 | 1.772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5854 | 0.2936 | 0.9229 | 3.709 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2520 | -1.579 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 479.68901 | 1.004 | -1.189 | -0.9273 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9853 | -0.2467 | -0.8591 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8033 | -1.061 | -0.5597 | -0.8314 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2483 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.68901 | 91.32 | -5.389 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05892 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7848 | 0.7337 | 1.547 | 0.9942 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68901</span> | 91.32 | 0.004565 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009725 | 0.6017 | 1.091 | 0.05892 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7848 | 0.7337 | 1.547 | 0.9942 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.772 | 1.160 | -0.07003 | -0.06455 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3646 | 0.6238 | 0.08418 | 1.806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5672 | 0.3711 | 0.9250 | 3.651 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2161 | -1.579 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 479.68474 | 1.003 | -1.190 | -0.9272 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9854 | -0.2468 | -0.8595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8031 | -1.061 | -0.5600 | -0.8323 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2479 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.68474 | 91.24 | -5.390 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9934 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68474</span> | 91.24 | 0.004563 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009724 | 0.6017 | 1.091 | 0.05890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9934 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.834 | 1.153 | -0.1599 | -0.05010 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3669 | 0.6355 | 0.09191 | 1.764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5796 | 0.2889 | 1.006 | 3.561 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2610 | -1.565 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 479.68016 | 1.004 | -1.190 | -0.9272 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9856 | -0.2468 | -0.8600 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8030 | -1.061 | -0.5602 | -0.8332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2475 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.68016 | 91.32 | -5.390 | -0.9050 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4125 | 1.091 | 0.05889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7850 | 0.7336 | 1.547 | 0.9926 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68016</span> | 91.32 | 0.004562 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009723 | 0.6017 | 1.091 | 0.05889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7850 | 0.7336 | 1.547 | 0.9926 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.891 | 1.158 | -0.06530 | -0.06447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3645 | 0.6207 | 0.1821 | 1.812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5486 | 0.3656 | 1.002 | 3.562 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2233 | -1.574 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 479.67614 | 1.003 | -1.190 | -0.9272 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9857 | -0.2468 | -0.8604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8028 | -1.061 | -0.5604 | -0.8341 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2472 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.67614 | 91.24 | -5.390 | -0.9049 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4124 | 1.091 | 0.05888 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7851 | 0.7335 | 1.546 | 0.9917 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.67614</span> | 91.24 | 0.004561 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009722 | 0.6017 | 1.091 | 0.05888 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7851 | 0.7335 | 1.546 | 0.9917 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.915 | 1.151 | -0.1574 | -0.04977 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | 0.6321 | 0.06058 | 1.705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5691 | 0.2601 | 0.8724 | 3.420 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2638 | -1.562 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 479.67180 | 1.004 | -1.191 | -0.9271 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9859 | -0.2469 | -0.8608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8027 | -1.061 | -0.5607 | -0.8349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2468 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.6718 | 91.33 | -5.391 | -0.9049 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4124 | 1.091 | 0.05887 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7852 | 0.7334 | 1.546 | 0.9909 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.6718</span> | 91.33 | 0.004560 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009722 | 0.6017 | 1.091 | 0.05887 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7852 | 0.7334 | 1.546 | 0.9909 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.074 | 1.157 | -0.05990 | -0.06452 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3645 | 0.6170 | 0.1286 | 1.744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5576 | 0.3161 | 0.9007 | 3.345 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2216 | -1.572 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 479.66809 | 1.003 | -1.191 | -0.9271 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9860 | -0.2469 | -0.8613 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8026 | -1.062 | -0.5609 | -0.8357 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2464 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.66809 | 91.23 | -5.391 | -0.9049 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4123 | 1.091 | 0.05885 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7853 | 0.7334 | 1.546 | 0.9901 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66809</span> | 91.23 | 0.004558 | 0.2880 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009721 | 0.6016 | 1.091 | 0.05885 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7853 | 0.7334 | 1.546 | 0.9901 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.161 | 1.149 | -0.1570 | -0.04911 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6293 | 0.04215 | 1.668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5621 | 0.2625 | 0.8940 | 3.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2611 | -1.561 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 479.66397 | 1.004 | -1.191 | -0.9271 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9862 | -0.2469 | -0.8617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8024 | -1.062 | -0.5611 | -0.8366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2460 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.66397 | 91.33 | -5.391 | -0.9049 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4122 | 1.091 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7854 | 0.7333 | 1.546 | 0.9893 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6990 | 1.968 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66397</span> | 91.33 | 0.004557 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009720 | 0.6016 | 1.091 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7854 | 0.7333 | 1.546 | 0.9893 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6990 | 1.968 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.197 | 1.155 | -0.05534 | -0.06448 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3644 | 0.6140 | 0.1526 | 1.765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5340 | 0.3555 | 0.9900 | 3.325 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2199 | -1.571 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 479.66043 | 1.003 | -1.191 | -0.9271 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9863 | -0.2469 | -0.8621 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8023 | -1.062 | -0.5613 | -0.8374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2456 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.66043 | 91.23 | -5.391 | -0.9048 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4122 | 1.090 | 0.05883 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7855 | 0.7332 | 1.545 | 0.9886 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.968 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66043</span> | 91.23 | 0.004556 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009719 | 0.6016 | 1.090 | 0.05883 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7855 | 0.7332 | 1.545 | 0.9886 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.968 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.161 | 1.147 | -0.1538 | -0.04891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6262 | 0.06581 | 1.677 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5453 | 0.2828 | 1.029 | 3.251 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2683 | -1.555 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 479.65652 | 1.004 | -1.192 | -0.9270 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9865 | -0.2469 | -0.8625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8022 | -1.062 | -0.5616 | -0.8382 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2452 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.65652 | 91.33 | -5.392 | -0.9048 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4121 | 1.090 | 0.05882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7856 | 0.7332 | 1.545 | 0.9878 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.65652</span> | 91.33 | 0.004554 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009718 | 0.6016 | 1.090 | 0.05882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7856 | 0.7332 | 1.545 | 0.9878 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.221 | 1.153 | -0.05203 | -0.06424 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3643 | 0.6104 | 0.04854 | 1.680 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5365 | 0.2999 | 0.7877 | 3.080 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2284 | -1.566 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 479.65328 | 1.003 | -1.192 | -0.9270 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9866 | -0.2470 | -0.8629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8020 | -1.062 | -0.5618 | -0.8389 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2448 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.65328 | 91.23 | -5.392 | -0.9048 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4120 | 1.090 | 0.05880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7857 | 0.7331 | 1.545 | 0.9871 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.65328</span> | 91.23 | 0.004553 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009717 | 0.6016 | 1.090 | 0.05880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7857 | 0.7331 | 1.545 | 0.9871 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.969 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.438 | 1.145 | -0.1538 | -0.04822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3675 | 0.6235 | 0.0004265 | 1.625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5487 | 0.2329 | 0.8499 | 3.058 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2658 | -1.554 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 479.64923 | 1.004 | -1.192 | -0.9270 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9868 | -0.2469 | -0.8633 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8019 | -1.062 | -0.5621 | -0.8396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2444 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.64923 | 91.32 | -5.392 | -0.9048 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4119 | 1.091 | 0.05879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7858 | 0.7330 | 1.544 | 0.9864 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.970 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64923</span> | 91.32 | 0.004551 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009716 | 0.6015 | 1.091 | 0.05879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7858 | 0.7330 | 1.544 | 0.9864 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.970 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.878 | 1.150 | -0.05277 | -0.06333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3643 | 0.6074 | 0.07271 | 1.651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5369 | 0.2992 | 0.8896 | 2.970 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2314 | -1.562 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 479.64621 | 1.003 | -1.193 | -0.9270 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9870 | -0.2469 | -0.8638 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8017 | -1.062 | -0.5623 | -0.8404 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2440 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.64621 | 91.23 | -5.393 | -0.9047 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4119 | 1.091 | 0.05878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7330 | 1.544 | 0.9856 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.970 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64621</span> | 91.23 | 0.004550 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009715 | 0.6015 | 1.091 | 0.05878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7330 | 1.544 | 0.9856 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.970 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.471 | 1.143 | -0.1506 | -0.04802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6203 | -0.003354 | 1.603 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5429 | 0.2243 | 0.9025 | 2.920 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2732 | -1.548 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 479.64228 | 1.004 | -1.193 | -0.9269 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9872 | -0.2468 | -0.8642 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8016 | -1.062 | -0.5627 | -0.8411 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2435 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.64228 | 91.32 | -5.393 | -0.9047 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4118 | 1.091 | 0.05877 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7860 | 0.7329 | 1.544 | 0.9850 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.971 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64228</span> | 91.32 | 0.004548 | 0.2881 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009714 | 0.6015 | 1.091 | 0.05877 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7860 | 0.7329 | 1.544 | 0.9850 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.971 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.744 | 1.148 | -0.05088 | -0.06289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3642 | 0.6037 | 0.03047 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5287 | 0.2733 | 0.8334 | 2.850 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2290 | -1.558 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 479.63935 | 1.003 | -1.193 | -0.9269 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9874 | -0.2468 | -0.8646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8014 | -1.062 | -0.5630 | -0.8419 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2431 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.63935 | 91.23 | -5.393 | -0.9047 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4117 | 1.091 | 0.05876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7861 | 0.7329 | 1.543 | 0.9843 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6986 | 1.971 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63935</span> | 91.23 | 0.004547 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009713 | 0.6015 | 1.091 | 0.05876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7861 | 0.7329 | 1.543 | 0.9843 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6986 | 1.971 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.432 | 1.140 | -0.1464 | -0.04798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | 0.6157 | -0.06295 | 1.547 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5341 | 0.1919 | 0.7582 | 2.801 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2698 | -1.544 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 479.63543 | 1.004 | -1.194 | -0.9268 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9876 | -0.2467 | -0.8650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8013 | -1.062 | -0.5633 | -0.8425 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2426 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.63543 | 91.32 | -5.394 | -0.9046 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4116 | 1.091 | 0.05874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7863 | 0.7328 | 1.543 | 0.9837 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.972 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63543</span> | 91.32 | 0.004545 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009712 | 0.6015 | 1.091 | 0.05874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7863 | 0.7328 | 1.543 | 0.9837 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.972 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.612 | 1.146 | -0.04876 | -0.06242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3640 | 0.6002 | 0.04743 | 1.619 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5199 | 0.2573 | 0.7734 | 2.739 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2298 | -1.553 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 479.63248 | 1.003 | -1.194 | -0.9268 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9878 | -0.2466 | -0.8655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8011 | -1.062 | -0.5636 | -0.8432 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2421 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.63248 | 91.23 | -5.394 | -0.9046 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4115 | 1.091 | 0.05873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7864 | 0.7328 | 1.543 | 0.9830 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.973 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63248</span> | 91.23 | 0.004543 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009710 | 0.6014 | 1.091 | 0.05873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7864 | 0.7328 | 1.543 | 0.9830 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.973 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.237 | 1.138 | -0.1400 | -0.04830 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3668 | 0.6108 | -0.07665 | 1.521 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5353 | 0.1893 | 0.7456 | 2.704 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2668 | -1.543 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 479.62869 | 1.004 | -1.195 | -0.9268 | -0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9880 | -0.2464 | -0.8659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8009 | -1.062 | -0.5639 | -0.8438 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2415 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.62869 | 91.32 | -5.395 | -0.9046 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4114 | 1.091 | 0.05872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7865 | 0.7327 | 1.542 | 0.9824 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6984 | 1.973 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62869</span> | 91.32 | 0.004541 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009709 | 0.6014 | 1.091 | 0.05872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7865 | 0.7327 | 1.542 | 0.9824 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6984 | 1.973 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.552 | 1.143 | -0.04554 | -0.06221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3637 | 0.5952 | -0.01323 | 1.563 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3448 | 0.2470 | 0.7924 | 2.643 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2272 | -1.550 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 479.62584 | 1.003 | -1.195 | -0.9268 | -0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9883 | -0.2463 | -0.8663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8008 | -1.062 | -0.5642 | -0.8446 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2410 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.62584 | 91.24 | -5.395 | -0.9046 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4113 | 1.091 | 0.05871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7866 | 0.7326 | 1.542 | 0.9817 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.974 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62584</span> | 91.24 | 0.004539 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009708 | 0.6014 | 1.091 | 0.05871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7866 | 0.7326 | 1.542 | 0.9817 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.974 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.148 | 1.135 | -0.1348 | -0.04846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3664 | 0.6063 | -0.009834 | 1.510 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5271 | 0.1803 | 0.7932 | 2.587 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2684 | -1.536 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 479.62216 | 1.004 | -1.195 | -0.9267 | -0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9885 | -0.2462 | -0.8667 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8007 | -1.062 | -0.5646 | -0.8451 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2404 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.62216 | 91.32 | -5.395 | -0.9045 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4112 | 1.091 | 0.05870 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7867 | 0.7326 | 1.541 | 0.9811 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62216</span> | 91.32 | 0.004537 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009706 | 0.6014 | 1.091 | 0.05870 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7867 | 0.7326 | 1.541 | 0.9811 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.404 | 1.140 | -0.04564 | -0.06187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3633 | 0.5903 | -0.01970 | 1.541 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5054 | 0.2303 | 0.6483 | 2.528 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2288 | -1.542 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 479.61938 | 1.003 | -1.196 | -0.9267 | -0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9887 | -0.2461 | -0.8672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8005 | -1.062 | -0.5649 | -0.8458 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2398 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.61938 | 91.24 | -5.396 | -0.9045 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4111 | 1.091 | 0.05868 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7868 | 0.7325 | 1.541 | 0.9805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6982 | 1.975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61938</span> | 91.24 | 0.004535 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009705 | 0.6013 | 1.091 | 0.05868 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7868 | 0.7325 | 1.541 | 0.9805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6982 | 1.975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.197 | 1.132 | -0.1312 | -0.04839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3660 | 0.6012 | 0.05916 | 1.560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4869 | 0.2015 | 0.8305 | 2.573 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2666 | -1.531 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 479.61563 | 1.003 | -1.196 | -0.9266 | -0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9890 | -0.2459 | -0.8676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8003 | -1.062 | -0.5653 | -0.8464 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2392 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.61563 | 91.32 | -5.396 | -0.9044 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4109 | 1.091 | 0.05867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7870 | 0.7325 | 1.541 | 0.9799 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6981 | 1.976 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61563</span> | 91.32 | 0.004533 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009703 | 0.6013 | 1.091 | 0.05867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7870 | 0.7325 | 1.541 | 0.9799 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6981 | 1.976 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.024 | 1.137 | -0.04591 | -0.06118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3629 | 0.5856 | 0.004035 | 1.536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4978 | 0.2329 | 0.6617 | 2.436 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2318 | -1.535 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 479.61337 | 1.003 | -1.197 | -0.9266 | -0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9892 | -0.2459 | -0.8680 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8001 | -1.063 | -0.5655 | -0.8471 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2388 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.61337 | 91.23 | -5.397 | -0.9044 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4109 | 1.091 | 0.05866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7871 | 0.7324 | 1.540 | 0.9792 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6980 | 1.977 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61337</span> | 91.23 | 0.004531 | 0.2881 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009702 | 0.6013 | 1.091 | 0.05866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7871 | 0.7324 | 1.540 | 0.9792 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6980 | 1.977 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.815 | 1.129 | -0.1342 | -0.04706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3660 | 0.5971 | -0.07697 | 1.438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5059 | 0.1462 | 0.6633 | 2.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2676 | -1.522 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 479.60932 | 1.003 | -1.197 | -0.9266 | -0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9894 | -0.2456 | -0.8684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8000 | -1.063 | -0.5659 | -0.8476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2381 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.60932 | 91.31 | -5.397 | -0.9044 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4107 | 1.091 | 0.05865 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7872 | 0.7324 | 1.540 | 0.9788 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.977 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60932</span> | 91.31 | 0.004529 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009700 | 0.6013 | 1.091 | 0.05865 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7872 | 0.7324 | 1.540 | 0.9788 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.977 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.699 | 1.134 | -0.04549 | -0.06017 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3630 | 0.5814 | -0.04512 | 1.484 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4915 | 0.2556 | 0.7248 | 2.322 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2317 | -1.529 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 479.60706 | 1.003 | -1.198 | -0.9265 | -0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9896 | -0.2455 | -0.8689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7998 | -1.063 | -0.5661 | -0.8484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2376 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.60706 | 91.23 | -5.398 | -0.9044 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4106 | 1.091 | 0.05863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7873 | 0.7323 | 1.540 | 0.9781 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.978 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60706</span> | 91.23 | 0.004527 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009699 | 0.6012 | 1.091 | 0.05863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7873 | 0.7323 | 1.540 | 0.9781 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.978 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.618 | 1.127 | -0.1276 | -0.04760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3656 | 0.5915 | -0.08622 | 1.415 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5531 | 0.1512 | 0.6569 | 2.298 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2620 | -1.540 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 479.60314 | 1.003 | -1.198 | -0.9265 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9899 | -0.2452 | -0.8692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7996 | -1.063 | -0.5665 | -0.8488 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2369 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.60314 | 91.31 | -5.398 | -0.9043 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4105 | 1.091 | 0.05862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7875 | 0.7322 | 1.539 | 0.9776 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.979 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60314</span> | 91.31 | 0.004525 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009698 | 0.6012 | 1.091 | 0.05862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7875 | 0.7322 | 1.539 | 0.9776 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.979 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.641 | 1.131 | -0.04213 | -0.06002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3627 | 0.5770 | -0.05114 | 1.464 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4913 | 0.1735 | 0.5980 | 2.238 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2116 | -1.521 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 479.60093 | 1.003 | -1.199 | -0.9265 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9901 | -0.2452 | -0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7994 | -1.063 | -0.5667 | -0.8495 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2363 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.60093 | 91.23 | -5.399 | -0.9043 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4104 | 1.091 | 0.05861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7876 | 0.7322 | 1.539 | 0.9769 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.980 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60093</span> | 91.23 | 0.004523 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009696 | 0.6012 | 1.091 | 0.05861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7876 | 0.7322 | 1.539 | 0.9769 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.980 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.657 | 1.124 | -0.1240 | -0.04721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3655 | 0.5872 | -0.09119 | 1.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4948 | 0.1646 | 0.6965 | 2.186 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2747 | -1.512 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 479.59701 | 1.003 | -1.199 | -0.9264 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9904 | -0.2448 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7992 | -1.063 | -0.5670 | -0.8499 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2356 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.59701 | 91.31 | -5.399 | -0.9043 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4103 | 1.091 | 0.05860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7321 | 1.539 | 0.9766 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.980 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.59701</span> | 91.31 | 0.004520 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009695 | 0.6012 | 1.091 | 0.05860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7321 | 1.539 | 0.9766 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.980 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.447 | 1.128 | -0.03826 | -0.05934 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3628 | 0.5721 | -0.04376 | 1.440 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4844 | 0.2233 | -0.3355 | 1.410 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3677 | -1.539 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 479.59436 | 1.003 | -1.200 | -0.9264 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9907 | -0.2446 | -0.8705 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7990 | -1.063 | -0.5669 | -0.8504 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2349 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.59436 | 91.23 | -5.400 | -0.9042 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4102 | 1.091 | 0.05858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7879 | 0.7320 | 1.539 | 0.9761 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.981 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.59436</span> | 91.23 | 0.004518 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009693 | 0.6011 | 1.091 | 0.05858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7879 | 0.7320 | 1.539 | 0.9761 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.981 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.478 | 1.121 | -0.1165 | -0.04761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3651 | 0.5835 | -0.09604 | 1.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4943 | 0.1086 | -0.4551 | 1.395 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3088 | -1.502 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 479.58979 | 1.003 | -1.200 | -0.9263 | -0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9910 | -0.2442 | -0.8708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7988 | -1.063 | -0.5665 | -0.8506 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2341 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.58979 | 91.30 | -5.400 | -0.9042 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4100 | 1.092 | 0.05858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7880 | 0.7319 | 1.539 | 0.9759 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.982 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58979</span> | 91.30 | 0.004516 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009691 | 0.6011 | 1.092 | 0.05858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7880 | 0.7319 | 1.539 | 0.9759 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.982 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.813 | 1.125 | -0.03904 | -0.05862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3624 | 0.5728 | -0.008587 | 1.448 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2657 | 0.1639 | 0.6610 | 2.108 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2622 | -1.501 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 479.58727 | 1.003 | -1.201 | -0.9263 | -0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9912 | -0.2441 | -0.8713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7987 | -1.063 | -0.5668 | -0.8514 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2335 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.58727 | 91.24 | -5.401 | -0.9042 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4099 | 1.092 | 0.05856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7881 | 0.7318 | 1.539 | 0.9751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.983 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58727</span> | 91.24 | 0.004513 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009690 | 0.6011 | 1.092 | 0.05856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7881 | 0.7318 | 1.539 | 0.9751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.983 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.987 | 1.119 | -0.1055 | -0.04878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3644 | 0.5797 | -0.03160 | 1.359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4809 | 0.09403 | -0.4184 | 1.337 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2770 | -1.489 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 479.58366 | 1.004 | -1.201 | -0.9263 | -0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9915 | -0.2438 | -0.8717 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7986 | -1.063 | -0.5667 | -0.8517 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2327 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.58366 | 91.32 | -5.401 | -0.9041 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4098 | 1.092 | 0.05855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7882 | 0.7317 | 1.539 | 0.9749 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58366</span> | 91.32 | 0.004511 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009688 | 0.6010 | 1.092 | 0.05855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7882 | 0.7317 | 1.539 | 0.9749 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.434 | 1.122 | -0.01954 | -0.06326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3597 | 0.5645 | -0.03484 | 1.404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4782 | 0.1697 | -0.05991 | 1.573 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2504 | -1.489 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 479.57994 | 1.003 | -1.202 | -0.9262 | -0.9358 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9918 | -0.2433 | -0.8720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7984 | -1.063 | -0.5664 | -0.8520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2319 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.57994 | 91.26 | -5.402 | -0.9041 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4096 | 1.092 | 0.05854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7884 | 0.7316 | 1.539 | 0.9746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.985 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57994</span> | 91.26 | 0.004508 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009686 | 0.6010 | 1.092 | 0.05854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7884 | 0.7316 | 1.539 | 0.9746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.985 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.328 | 1.117 | -0.07952 | -0.05137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3636 | 0.5738 | 0.02815 | 1.418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4669 | 0.1345 | 0.7258 | 2.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2949 | -1.476 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 479.57683 | 1.004 | -1.202 | -0.9262 | -0.9358 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9921 | -0.2431 | -0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7982 | -1.064 | -0.5667 | -0.8526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2311 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.57683 | 91.32 | -5.402 | -0.9041 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4095 | 1.092 | 0.05853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7885 | 0.7315 | 1.539 | 0.9740 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.986 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57683</span> | 91.32 | 0.004505 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009684 | 0.6010 | 1.092 | 0.05853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7885 | 0.7315 | 1.539 | 0.9740 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.986 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.369 | 1.121 | -0.01236 | -0.06033 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3618 | 0.5608 | -0.009614 | 1.424 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4677 | 0.1416 | 0.6194 | 1.932 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2634 | -1.483 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 479.57433 | 1.003 | -1.203 | -0.9262 | -0.9358 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9924 | -0.2429 | -0.8728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7980 | -1.064 | -0.5671 | -0.8530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2304 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.57433 | 91.25 | -5.403 | -0.9041 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4094 | 1.092 | 0.05852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7886 | 0.7315 | 1.539 | 0.9736 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 1.987 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57433</span> | 91.25 | 0.004503 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009683 | 0.6009 | 1.092 | 0.05852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7886 | 0.7315 | 1.539 | 0.9736 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 1.987 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.507 | 1.111 | -0.09183 | -0.05192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3614 | 0.5665 | -0.03887 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4753 | 0.07826 | 0.5528 | 1.905 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2844 | -1.468 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 479.57116 | 1.003 | -1.204 | -0.9262 | -0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9927 | -0.2425 | -0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7978 | -1.064 | -0.5674 | -0.8534 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2297 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.57116 | 91.32 | -5.404 | -0.9040 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4092 | 1.092 | 0.05851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7888 | 0.7315 | 1.538 | 0.9732 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6973 | 1.988 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57116</span> | 91.32 | 0.004500 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009681 | 0.6009 | 1.092 | 0.05851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7888 | 0.7315 | 1.538 | 0.9732 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6973 | 1.988 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.953 | 1.117 | -0.01332 | -0.05913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3618 | 0.5550 | -0.01942 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4588 | 0.1396 | 0.5378 | 1.901 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2564 | -1.475 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 479.56857 | 1.003 | -1.204 | -0.9261 | -0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9930 | -0.2422 | -0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7976 | -1.064 | -0.5677 | -0.8539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2289 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.56857 | 91.25 | -5.404 | -0.9040 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4091 | 1.092 | 0.05850 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7889 | 0.7314 | 1.538 | 0.9728 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6972 | 1.989 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56857</span> | 91.25 | 0.004497 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009679 | 0.6009 | 1.092 | 0.05850 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7889 | 0.7314 | 1.538 | 0.9728 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6972 | 1.989 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.279 | 1.109 | -0.08378 | -0.05051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3625 | 0.5609 | -0.06234 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5093 | 0.06989 | -1.266 | 1.852 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2753 | -1.463 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 479.56430 | 1.003 | -1.205 | -0.9261 | -0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9933 | -0.2419 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7974 | -1.064 | -0.5672 | -0.8543 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2281 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.5643 | 91.31 | -5.405 | -0.9040 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4090 | 1.093 | 0.05849 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7891 | 0.7314 | 1.538 | 0.9724 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6971 | 1.990 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.5643</span> | 91.31 | 0.004495 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009677 | 0.6008 | 1.093 | 0.05849 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7891 | 0.7314 | 1.538 | 0.9724 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6971 | 1.990 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.181 | 1.113 | -0.01711 | -0.05862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3610 | 0.5490 | -0.06295 | 1.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4495 | 0.1474 | 0.6781 | 1.913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2455 | -1.468 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 479.56239 | 1.003 | -1.205 | -0.9261 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9935 | -0.2417 | -0.8744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7972 | -1.064 | -0.5674 | -0.8549 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2275 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.56239 | 91.24 | -5.405 | -0.9040 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4089 | 1.093 | 0.05847 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7892 | 0.7313 | 1.538 | 0.9718 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6970 | 1.990 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56239</span> | 91.24 | 0.004493 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009675 | 0.6008 | 1.093 | 0.05847 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7892 | 0.7313 | 1.538 | 0.9718 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6970 | 1.990 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.516 | 1.106 | -0.09308 | -0.04714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3636 | 0.5580 | -0.04406 | 1.488 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4662 | 0.05187 | 0.6104 | 1.787 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2769 | -1.453 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 479.55877 | 1.003 | -1.206 | -0.9261 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9938 | -0.2414 | -0.8747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7970 | -1.064 | -0.5678 | -0.8553 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2268 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.55877 | 91.31 | -5.406 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4087 | 1.093 | 0.05846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7894 | 0.7313 | 1.538 | 0.9714 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6969 | 1.991 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55877</span> | 91.31 | 0.004490 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009674 | 0.6008 | 1.093 | 0.05846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7894 | 0.7313 | 1.538 | 0.9714 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6969 | 1.991 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.254 | 1.111 | -0.01255 | -0.05783 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3613 | 0.5437 | -0.01079 | 1.366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4954 | 0.1048 | 0.5565 | 1.745 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2417 | -1.458 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 479.55696 | 1.003 | -1.206 | -0.9261 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9940 | -0.2413 | -0.8753 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7968 | -1.064 | -0.5681 | -0.8559 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2262 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.55696 | 91.24 | -5.406 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4086 | 1.093 | 0.05845 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7895 | 0.7312 | 1.537 | 0.9708 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.992 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55696</span> | 91.24 | 0.004488 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009672 | 0.6008 | 1.093 | 0.05845 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7895 | 0.7312 | 1.537 | 0.9708 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.992 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.420 | 1.104 | -0.08938 | -0.04652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3638 | 0.5524 | -0.03600 | 1.474 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4537 | 0.08714 | 0.5943 | 1.686 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2777 | -1.443 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 479.55331 | 1.003 | -1.207 | -0.9260 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9943 | -0.2409 | -0.8756 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7966 | -1.064 | -0.5684 | -0.8562 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2254 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.55331 | 91.31 | -5.407 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4085 | 1.093 | 0.05844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7897 | 0.7312 | 1.537 | 0.9706 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.993 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55331</span> | 91.31 | 0.004485 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009670 | 0.6007 | 1.093 | 0.05844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7897 | 0.7312 | 1.537 | 0.9706 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.993 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.940 | 1.107 | -0.01326 | -0.05734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3610 | 0.5380 | -0.03050 | 1.334 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4419 | 0.09953 | 0.4758 | 1.660 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2363 | -1.448 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 479.55178 | 1.003 | -1.208 | -0.9260 | -0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9945 | -0.2409 | -0.8762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7964 | -1.064 | -0.5686 | -0.8569 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2248 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.55178 | 91.23 | -5.408 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4084 | 1.093 | 0.05842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 0.7311 | 1.537 | 0.9699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.994 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55178</span> | 91.23 | 0.004483 | 0.2882 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009668 | 0.6007 | 1.093 | 0.05842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 0.7311 | 1.537 | 0.9699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.994 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.846 | 1.100 | -0.09130 | -0.04553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3638 | 0.5474 | -0.02936 | 1.430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4494 | 0.05105 | 0.6245 | 1.611 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2724 | -1.435 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 479.54790 | 1.003 | -1.208 | -0.9260 | -0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9948 | -0.2405 | -0.8765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7962 | -1.064 | -0.5690 | -0.8571 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2240 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.5479 | 91.30 | -5.408 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4083 | 1.093 | 0.05841 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7899 | 0.7311 | 1.536 | 0.9697 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.995 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.5479</span> | 91.30 | 0.004480 | 0.2883 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009667 | 0.6007 | 1.093 | 0.05841 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7899 | 0.7311 | 1.536 | 0.9697 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.995 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.570 | 1.104 | -0.01594 | -0.05674 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3607 | 0.5327 | -0.02577 | 1.253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4401 | 0.07544 | -0.5163 | 0.8741 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3456 | -1.445 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 479.54587 | 1.003 | -1.209 | -0.9260 | -0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9951 | -0.2405 | -0.8771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7960 | -1.064 | -0.5687 | -0.8576 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2233 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.54587 | 91.23 | -5.409 | -0.9039 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4081 | 1.093 | 0.05839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7901 | 0.7310 | 1.537 | 0.9693 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.995 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.54587</span> | 91.23 | 0.004478 | 0.2883 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009665 | 0.6006 | 1.093 | 0.05839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7901 | 0.7310 | 1.537 | 0.9693 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.995 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.902 | 1.097 | -0.08880 | -0.04568 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3633 | 0.5436 | -0.03820 | 1.421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4438 | 0.04451 | 0.5507 | 1.558 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2862 | -1.423 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 479.54157 | 1.003 | -1.209 | -0.9260 | -0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9954 | -0.2399 | -0.8773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7958 | -1.064 | -0.5687 | -0.8577 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.54157 | 91.30 | -5.409 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4080 | 1.093 | 0.05839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7902 | 0.7309 | 1.537 | 0.9691 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.996 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.54157</span> | 91.30 | 0.004475 | 0.2883 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009663 | 0.6006 | 1.093 | 0.05839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7902 | 0.7309 | 1.537 | 0.9691 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.996 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.063 | 1.100 | -0.01768 | -0.05631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3603 | 0.5311 | -0.05904 | 1.468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4400 | 0.06384 | 0.5216 | 1.564 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2548 | -1.433 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 479.53906 | 1.003 | -1.210 | -0.9259 | -0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9956 | -0.2399 | -0.8780 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7956 | -1.064 | -0.5689 | -0.8584 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2218 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.53906 | 91.25 | -5.410 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4079 | 1.093 | 0.05837 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7904 | 0.7309 | 1.536 | 0.9684 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.997 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53906</span> | 91.25 | 0.004472 | 0.2883 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009661 | 0.6006 | 1.093 | 0.05837 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7904 | 0.7309 | 1.536 | 0.9684 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.997 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.131 | 1.095 | -0.06506 | -0.04908 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3620 | 0.5356 | -0.007514 | 1.441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4274 | 0.08578 | -0.3543 | 0.8441 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2944 | -1.418 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 479.53616 | 1.004 | -1.210 | -0.9259 | -0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9959 | -0.2396 | -0.8785 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7954 | -1.064 | -0.5688 | -0.8586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2210 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.53616 | 91.33 | -5.410 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4077 | 1.094 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7905 | 0.7308 | 1.537 | 0.9682 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.998 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53616</span> | 91.33 | 0.004470 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009659 | 0.6005 | 1.094 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7905 | 0.7308 | 1.537 | 0.9682 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.998 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.979 | 1.099 | 0.01619 | -0.06233 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3580 | 0.5217 | -0.09749 | 1.245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4289 | 0.1115 | -0.5282 | 0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3266 | -1.417 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 479.53242 | 1.003 | -1.211 | -0.9259 | -0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9962 | -0.2391 | -0.8787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7953 | -1.065 | -0.5685 | -0.8588 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2202 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.53242 | 91.27 | -5.411 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4076 | 1.094 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7906 | 0.7307 | 1.537 | 0.9681 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.999 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53242</span> | 91.27 | 0.004467 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009657 | 0.6005 | 1.094 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7906 | 0.7307 | 1.537 | 0.9681 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.999 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.679 | 1.093 | -0.04308 | -0.05224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3605 | 0.5318 | -0.002555 | 1.446 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4215 | 0.05786 | 0.6079 | 1.538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2997 | -1.401 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 479.52958 | 1.004 | -1.212 | -0.9259 | -0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9965 | -0.2388 | -0.8793 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7951 | -1.065 | -0.5686 | -0.8593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2194 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.52958 | 91.33 | -5.412 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4075 | 1.094 | 0.05833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7908 | 0.7306 | 1.537 | 0.9676 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.000 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52958</span> | 91.33 | 0.004464 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009655 | 0.6005 | 1.094 | 0.05833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7908 | 0.7306 | 1.537 | 0.9676 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.000 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.139 | 1.094 | 0.01046 | -0.06226 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3570 | 0.5194 | -0.09592 | 1.421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4323 | 0.06052 | -0.5454 | 0.7071 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2962 | -1.410 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 479.52646 | 1.003 | -1.212 | -0.9259 | -0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9968 | -0.2384 | -0.8797 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7949 | -1.065 | -0.5684 | -0.8594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2186 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.52646 | 91.26 | -5.412 | -0.9038 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4073 | 1.094 | 0.05832 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7909 | 0.7304 | 1.537 | 0.9675 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.001 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52646</span> | 91.26 | 0.004461 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009653 | 0.6005 | 1.094 | 0.05832 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7909 | 0.7304 | 1.537 | 0.9675 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.001 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.758 | 1.088 | -0.05217 | -0.05158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3593 | 0.5291 | -0.05980 | 1.185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4227 | -2.218 | -0.3659 | 0.8223 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2423 | -1.392 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 479.52294 | 1.003 | -1.213 | -0.9258 | -0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9971 | -0.2379 | -0.8800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7947 | -1.064 | -0.5681 | -0.8596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2178 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.52294 | 91.30 | -5.413 | -0.9037 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4072 | 1.094 | 0.05831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7311 | 1.537 | 0.9673 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6967 | 2.002 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52294</span> | 91.30 | 0.004458 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009652 | 0.6004 | 1.094 | 0.05831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7311 | 1.537 | 0.9673 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6967 | 2.002 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.7571 | 1.091 | -0.01328 | -0.05733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3573 | 0.5211 | 0.006105 | 1.423 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4119 | 0.1268 | 0.6771 | 1.465 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3146 | -1.386 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 479.52041 | 1.003 | -1.213 | -0.9258 | -0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9973 | -0.2380 | -0.8807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7945 | -1.064 | -0.5684 | -0.8604 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.52041 | 91.27 | -5.413 | -0.9037 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4071 | 1.094 | 0.05829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7912 | 0.7311 | 1.537 | 0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.003 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52041</span> | 91.27 | 0.004456 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009650 | 0.6004 | 1.094 | 0.05829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7912 | 0.7311 | 1.537 | 0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.003 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.400 | 1.087 | -0.04852 | -0.05189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3585 | 0.5236 | -0.05100 | 1.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4319 | 0.01564 | 0.3566 | 1.324 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3221 | -1.379 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 479.51911 | 1.004 | -1.214 | -0.9258 | -0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9976 | -0.2379 | -0.8812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7944 | -1.064 | -0.5686 | -0.8609 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2166 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.51911 | 91.35 | -5.414 | -0.9037 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4070 | 1.094 | 0.05828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7913 | 0.7310 | 1.537 | 0.9661 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.004 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51911</span> | 91.35 | 0.004454 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009648 | 0.6004 | 1.094 | 0.05828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7913 | 0.7310 | 1.537 | 0.9661 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.004 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.458 | 1.092 | 0.04306 | -0.06507 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3552 | 0.5068 | -0.06807 | 1.418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4090 | 0.1358 | -0.5109 | 0.5676 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2804 | -1.390 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 479.51487 | 1.003 | -1.215 | -0.9258 | -0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9978 | -0.2377 | -0.8817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7942 | -1.064 | -0.5685 | -0.8612 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2158 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.51487 | 91.27 | -5.415 | -0.9037 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4069 | 1.094 | 0.05826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7914 | 0.7307 | 1.537 | 0.9658 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.005 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51487</span> | 91.27 | 0.004451 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009647 | 0.6003 | 1.094 | 0.05826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7914 | 0.7307 | 1.537 | 0.9658 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.005 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.582 | 1.084 | -0.03533 | -0.05340 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3581 | 0.5175 | -0.06480 | 1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4224 | 0.03489 | -0.5536 | 0.6041 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2386 | -1.371 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 479.51208 | 1.004 | -1.215 | -0.9258 | -0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9981 | -0.2375 | -0.8823 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7939 | -1.065 | -0.5682 | -0.8615 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2150 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.51208 | 91.34 | -5.415 | -0.9037 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4067 | 1.094 | 0.05824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7916 | 0.7306 | 1.537 | 0.9655 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.006 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51208</span> | 91.34 | 0.004449 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009645 | 0.6003 | 1.094 | 0.05824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7916 | 0.7306 | 1.537 | 0.9655 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.006 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.943 | 1.087 | 0.02817 | -0.06279 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3555 | 0.5065 | -0.06060 | 1.305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4115 | 0.06912 | 0.4865 | 1.240 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2990 | -1.371 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 479.50842 | 1.003 | -1.216 | -0.9258 | -0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9984 | -0.2372 | -0.8827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7937 | -1.065 | -0.5683 | -0.8618 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2141 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.50842 | 91.29 | -5.416 | -0.9037 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4066 | 1.095 | 0.05823 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7918 | 0.7302 | 1.537 | 0.9652 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6962 | 2.007 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.50842</span> | 91.29 | 0.004446 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009643 | 0.6003 | 1.095 | 0.05823 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7918 | 0.7302 | 1.537 | 0.9652 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6962 | 2.007 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7463 | 1.081 | -0.02105 | -0.05532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3572 | 0.5118 | -0.07839 | 1.134 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4206 | 0.01709 | -0.5616 | 0.5218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2429 | -1.361 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 479.50515 | 1.004 | -1.216 | -0.9258 | -0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9987 | -0.2372 | -0.8834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7935 | -1.065 | -0.5680 | -0.8621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2133 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.50515 | 91.33 | -5.416 | -0.9037 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4065 | 1.095 | 0.05821 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7919 | 0.7302 | 1.537 | 0.9649 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.008 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.50515</span> | 91.33 | 0.004443 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009641 | 0.6002 | 1.095 | 0.05821 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7919 | 0.7302 | 1.537 | 0.9649 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.008 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 479.49887 | 1.004 | -1.219 | -0.9257 | -0.9350 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.9997 | -0.2363 | -0.8851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7928 | -1.066 | -0.5675 | -0.8630 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2104 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.49887 | 91.39 | -5.419 | -0.9037 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4060 | 1.095 | 0.05816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7925 | 0.7293 | 1.538 | 0.9641 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.011 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.49887</span> | 91.39 | 0.004434 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009634 | 0.6001 | 1.095 | 0.05816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7925 | 0.7293 | 1.538 | 0.9641 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.011 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.922 | 1.081 | 0.1004 | -0.07252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3520 | 0.4871 | 0.2543 | 1.578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3854 | 0.03465 | -0.5794 | 0.4083 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2550 | -1.344 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 479.48147 | 1.003 | -1.221 | -0.9257 | -0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -1.001 | -0.2344 | -0.8861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7921 | -1.067 | -0.5658 | -0.8636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2068 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.48147 | 91.29 | -5.421 | -0.9036 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.643 | 0.4054 | 1.096 | 0.05813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7930 | 0.7283 | 1.540 | 0.9635 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.016 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.48147</span> | 91.29 | 0.004421 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009626 | 0.6000 | 1.096 | 0.05813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7930 | 0.7283 | 1.540 | 0.9635 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.016 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 479.46291 | 1.003 | -1.226 | -0.9256 | -0.9345 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.032 | -1.003 | -0.2312 | -0.8874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7910 | -1.069 | -0.5631 | -0.8644 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2012 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.46291 | 91.29 | -5.426 | -0.9035 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.645 | 0.4045 | 1.097 | 0.05809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7937 | 0.7267 | 1.543 | 0.9627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.022 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.46291</span> | 91.29 | 0.004402 | 0.2883 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009612 | 0.5998 | 1.097 | 0.05809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7937 | 0.7267 | 1.543 | 0.9627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.022 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 479.38653 | 1.003 | -1.248 | -0.9250 | -0.9332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.039 | -1.013 | -0.2154 | -0.8940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -1.078 | -0.5497 | -0.8687 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.1734 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.38653 | 91.26 | -5.448 | -0.9030 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.652 | 0.4000 | 1.104 | 0.05790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7975 | 0.7188 | 1.559 | 0.9587 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.056 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.38653</span> | 91.26 | 0.004306 | 0.2884 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009547 | 0.5987 | 1.104 | 0.05790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7975 | 0.7188 | 1.559 | 0.9587 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.056 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 479.33405 | 1.002 | -1.333 | -0.9226 | -0.9281 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.066 | -1.051 | -0.1533 | -0.9198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7659 | -1.112 | -0.4971 | -0.8853 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.06439 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.33405 | 91.15 | -5.533 | -0.9008 | -2.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.678 | 0.3823 | 1.129 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8121 | 0.6876 | 1.621 | 0.9427 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 2.188 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.33405</span> | 91.15 | 0.003953 | 0.2889 | 0.1119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009294 | 0.5944 | 1.129 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8121 | 0.6876 | 1.621 | 0.9427 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 2.188 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.35 | 0.8049 | 0.3265 | -0.06456 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3038 | 0.2091 | 1.763 | 1.473 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5535 | -2.463 | 1.244 | -0.6274 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.702 | -0.2760 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 479.70817 | 1.005 | -1.492 | -0.9504 | -0.9122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.121 | -1.106 | -0.1774 | -0.9510 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7305 | -1.145 | -0.4385 | -0.8800 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.177 | -0.01012 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.70817 | 91.47 | -5.692 | -0.9256 | -2.175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.734 | 0.3572 | 1.119 | 0.05625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 0.6579 | 1.691 | 0.9478 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6020 | 2.254 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.70817</span> | 91.47 | 0.003371 | 0.2838 | 0.1137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008794 | 0.5884 | 1.119 | 0.05625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 0.6579 | 1.691 | 0.9478 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6020 | 2.254 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 479.27063 | 1.005 | -1.375 | -0.9298 | -0.9240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.080 | -1.065 | -0.1597 | -0.9281 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7567 | -1.120 | -0.4820 | -0.8839 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.095 | -0.05030 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.27063 | 91.42 | -5.575 | -0.9073 | -2.186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.693 | 0.3758 | 1.127 | 0.05692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8189 | 0.6801 | 1.639 | 0.9441 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6726 | 2.206 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.27063</span> | 91.42 | 0.003793 | 0.2876 | 0.1123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009162 | 0.5929 | 1.127 | 0.05692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8189 | 0.6801 | 1.639 | 0.9441 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6726 | 2.206 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.862 | 0.7516 | 0.3576 | -0.07893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2806 | -0.4298 | 1.369 | 1.213 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5227 | -2.562 | 2.801 | -1.010 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.234 | -0.5388 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 479.18239 | 1.005 | -1.423 | -0.9401 | -0.9189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1729 | -0.9195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7414 | -1.117 | -0.4967 | -0.8806 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04375 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.18239 | 91.43 | -5.623 | -0.9165 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.710 | 0.3764 | 1.121 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.6834 | 1.622 | 0.9472 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.213 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.18239</span> | 91.43 | 0.003613 | 0.2857 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009001 | 0.5930 | 1.121 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.6834 | 1.622 | 0.9472 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.213 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.797 | 0.6564 | -0.1913 | -0.04289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2359 | -0.3012 | 1.209 | 1.124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4349 | -2.322 | 2.160 | -0.7215 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1578 | -0.4171 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 479.53483 | 0.9938 | -1.508 | -0.8927 | -0.9141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.127 | -1.054 | -0.1802 | -0.9016 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7110 | -1.089 | -0.5260 | -0.8567 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.093 | -0.01567 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.53483 | 90.44 | -5.708 | -0.8742 | -2.177 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.740 | 0.3812 | 1.118 | 0.05768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8523 | 0.7081 | 1.587 | 0.9700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6741 | 2.248 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53483</span> | 90.44 | 0.003320 | 0.2944 | 0.1134 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008741 | 0.5942 | 1.118 | 0.05768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8523 | 0.7081 | 1.587 | 0.9700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6741 | 2.248 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 479.57437 | 0.9943 | -1.436 | -0.9336 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.102 | -1.062 | -0.1777 | -0.9209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7362 | -1.106 | -0.5073 | -0.8753 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03890 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.57437 | 90.49 | -5.636 | -0.9106 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.715 | 0.3775 | 1.119 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | 0.6933 | 1.609 | 0.9523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57437</span> | 90.49 | 0.003567 | 0.2869 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008961 | 0.5933 | 1.119 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | 0.6933 | 1.609 | 0.9523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 479.18328 | 1.003 | -1.424 | -0.9400 | -0.9189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1736 | -0.9201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7412 | -1.115 | -0.4980 | -0.8802 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04351 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.18328 | 91.28 | -5.624 | -0.9164 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6847 | 1.620 | 0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.18328</span> | 91.28 | 0.003612 | 0.2857 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009000 | 0.5930 | 1.121 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6847 | 1.620 | 0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 479.17990 | 1.004 | -1.423 | -0.9401 | -0.9189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1732 | -0.9198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7413 | -1.116 | -0.4973 | -0.8805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04364 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.1799 | 91.36 | -5.623 | -0.9164 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.710 | 0.3764 | 1.121 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8301 | 0.6840 | 1.621 | 0.9474 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.1799</span> | 91.36 | 0.003612 | 0.2857 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009001 | 0.5930 | 1.121 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8301 | 0.6840 | 1.621 | 0.9474 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.933 | 0.6514 | -0.2757 | -0.03244 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2382 | -0.2823 | 1.183 | 1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4397 | -2.345 | 2.145 | -0.7620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1240 | -0.3947 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 479.17667 | 1.005 | -1.424 | -0.9399 | -0.9189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1735 | -0.9200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7411 | -1.116 | -0.4978 | -0.8802 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04350 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.17667 | 91.44 | -5.624 | -0.9162 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6845 | 1.621 | 0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17667</span> | 91.44 | 0.003611 | 0.2857 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009000 | 0.5930 | 1.121 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6845 | 1.621 | 0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.521 | 0.6547 | -0.1751 | -0.04313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2353 | -0.2995 | 1.118 | 1.121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4506 | -2.323 | 2.084 | -0.7259 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1653 | -0.4503 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 479.17418 | 1.004 | -1.424 | -0.9398 | -0.9188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1738 | -0.9202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7410 | -1.115 | -0.4983 | -0.8800 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04335 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.17418 | 91.36 | -5.624 | -0.9161 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8303 | 0.6850 | 1.620 | 0.9478 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17418</span> | 91.36 | 0.003610 | 0.2857 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008999 | 0.5930 | 1.121 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8303 | 0.6850 | 1.620 | 0.9478 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.859 | 0.6491 | -0.2708 | -0.03145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2380 | -0.2786 | 1.113 | 1.074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4387 | -2.285 | 2.045 | -0.7498 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1354 | -0.4011 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 479.17107 | 1.005 | -1.424 | -0.9396 | -0.9188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1740 | -0.9204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7408 | -1.114 | -0.4988 | -0.8798 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04320 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.17107 | 91.44 | -5.624 | -0.9160 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3766 | 1.121 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8305 | 0.6855 | 1.619 | 0.9480 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17107</span> | 91.44 | 0.003609 | 0.2858 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008997 | 0.5930 | 1.121 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8305 | 0.6855 | 1.619 | 0.9480 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.569 | 0.6522 | -0.1642 | -0.04243 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2349 | -0.2958 | 1.101 | 1.106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4222 | -2.201 | 1.058 | -0.2096 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2358 | -0.4015 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 479.16873 | 1.004 | -1.425 | -0.9393 | -0.9188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.064 | -0.1743 | -0.9206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7406 | -1.114 | -0.4991 | -0.8797 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04303 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.16873 | 91.36 | -5.625 | -0.9158 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3766 | 1.121 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8306 | 0.6860 | 1.619 | 0.9481 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16873</span> | 91.36 | 0.003607 | 0.2858 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008996 | 0.5931 | 1.121 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8306 | 0.6860 | 1.619 | 0.9481 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.214 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.833 | 0.6464 | -0.2551 | -0.03020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2388 | -0.2745 | 1.092 | 1.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4378 | -2.238 | 1.100 | -0.2036 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2823 | -0.3907 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 479.16547 | 1.005 | -1.426 | -0.9390 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1745 | -0.9206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7403 | -1.113 | -0.4993 | -0.8795 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04283 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.16547 | 91.42 | -5.626 | -0.9155 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3767 | 1.121 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8308 | 0.6865 | 1.619 | 0.9483 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16547</span> | 91.42 | 0.003605 | 0.2859 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008994 | 0.5931 | 1.121 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8308 | 0.6865 | 1.619 | 0.9483 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.367 | 0.6482 | -0.1602 | -0.03907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2347 | -0.2874 | 1.147 | 1.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4142 | -2.141 | 1.081 | -0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2414 | -0.4049 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 479.16316 | 1.004 | -1.426 | -0.9389 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1748 | -0.9208 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7401 | -1.113 | -0.4996 | -0.8794 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04264 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.16316 | 91.36 | -5.626 | -0.9154 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3768 | 1.120 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8310 | 0.6872 | 1.618 | 0.9484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16316</span> | 91.36 | 0.003603 | 0.2859 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008992 | 0.5931 | 1.120 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8310 | 0.6872 | 1.618 | 0.9484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.810 | 0.6431 | -0.2376 | -0.02872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2384 | -0.2689 | 1.073 | 1.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4195 | -2.179 | 2.025 | -0.6985 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1403 | -0.3873 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 479.15976 | 1.005 | -1.427 | -0.9385 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1751 | -0.9208 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7399 | -1.112 | -0.5000 | -0.8792 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04242 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.15976 | 91.41 | -5.627 | -0.9150 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3768 | 1.120 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8311 | 0.6876 | 1.618 | 0.9486 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15976</span> | 91.41 | 0.003601 | 0.2860 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008990 | 0.5931 | 1.120 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8311 | 0.6876 | 1.618 | 0.9486 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.385 | 0.6444 | -0.1513 | -0.03575 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2363 | -0.2788 | 1.057 | 1.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4304 | -2.135 | 1.940 | -0.6607 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1552 | -0.4034 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 479.15697 | 1.004 | -1.427 | -0.9385 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1754 | -0.9212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7397 | -1.111 | -0.5007 | -0.8790 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.15697 | 91.37 | -5.627 | -0.9150 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3769 | 1.120 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8312 | 0.6883 | 1.617 | 0.9488 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15697</span> | 91.37 | 0.003600 | 0.2860 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008990 | 0.5931 | 1.120 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8312 | 0.6883 | 1.617 | 0.9488 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.828 | 0.6406 | -0.2090 | -0.02895 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2376 | -0.2659 | 1.059 | 0.9695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4112 | -2.078 | 1.041 | -0.1304 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2608 | -0.3859 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 479.15524 | 1.005 | -1.427 | -0.9384 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1758 | -0.9215 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7396 | -1.111 | -0.5010 | -0.8789 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.15524 | 91.45 | -5.627 | -0.9149 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3769 | 1.120 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8313 | 0.6888 | 1.617 | 0.9489 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15524</span> | 91.45 | 0.003599 | 0.2860 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008989 | 0.5931 | 1.120 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8313 | 0.6888 | 1.617 | 0.9489 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.215 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.191 | 0.6447 | -0.1017 | -0.04048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2348 | -0.2858 | 1.095 | 1.009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3975 | -1.983 | 1.956 | -0.5702 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1591 | -0.3996 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 479.15192 | 1.004 | -1.428 | -0.9381 | -0.9186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.063 | -0.1760 | -0.9214 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7393 | -1.110 | -0.5013 | -0.8787 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04194 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.15192 | 91.38 | -5.628 | -0.9146 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3770 | 1.120 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8315 | 0.6892 | 1.616 | 0.9490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15192</span> | 91.38 | 0.003597 | 0.2861 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008987 | 0.5932 | 1.120 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8315 | 0.6892 | 1.616 | 0.9490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.012 | 0.6390 | -0.1711 | -0.03027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2366 | -0.2653 | 1.098 | 0.9640 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4101 | -2.024 | 0.9749 | -0.1142 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2645 | -0.3871 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 479.14897 | 1.005 | -1.428 | -0.9380 | -0.9186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.063 | -0.1764 | -0.9218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7392 | -1.110 | -0.5017 | -0.8787 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04178 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.14897 | 91.42 | -5.628 | -0.9146 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3771 | 1.120 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8317 | 0.6900 | 1.616 | 0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14897</span> | 91.42 | 0.003596 | 0.2861 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008986 | 0.5932 | 1.120 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8317 | 0.6900 | 1.616 | 0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 479.14773 | 1.005 | -1.428 | -0.9379 | -0.9186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.062 | -0.1770 | -0.9223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7390 | -1.109 | -0.5022 | -0.8786 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04159 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.14773 | 91.47 | -5.628 | -0.9145 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3771 | 1.120 | 0.05708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8318 | 0.6909 | 1.615 | 0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14773</span> | 91.47 | 0.003595 | 0.2861 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008985 | 0.5932 | 1.120 | 0.05708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8318 | 0.6909 | 1.615 | 0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.333 | 0.6414 | -0.06030 | -0.04156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2338 | -0.2836 | 1.014 | 1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3897 | -1.922 | 0.8816 | -0.1288 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1940 | -0.4011 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 479.14119 | 1.004 | -1.430 | -0.9374 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.062 | -0.1775 | -0.9218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7383 | -1.108 | -0.5019 | -0.8783 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04112 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.14119 | 91.39 | -5.630 | -0.9140 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.713 | 0.3774 | 1.119 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8323 | 0.6917 | 1.616 | 0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14119</span> | 91.39 | 0.003588 | 0.2862 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008979 | 0.5933 | 1.119 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8323 | 0.6917 | 1.616 | 0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4299 | 0.6321 | -0.1435 | -0.02760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2360 | -0.2479 | 1.019 | 0.9518 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3967 | -1.860 | 1.900 | -0.5922 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1599 | -0.3806 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 479.13501 | 1.005 | -1.431 | -0.9373 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.101 | -1.062 | -0.1783 | -0.9226 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7379 | -1.106 | -0.5035 | -0.8778 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04080 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.13501 | 91.42 | -5.631 | -0.9139 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.713 | 0.3775 | 1.119 | 0.05707 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8326 | 0.6932 | 1.614 | 0.9500 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.13501</span> | 91.42 | 0.003586 | 0.2862 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008977 | 0.5933 | 1.119 | 0.05707 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8326 | 0.6932 | 1.614 | 0.9500 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.960 | 0.6324 | -0.1010 | -0.03176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2344 | -0.2516 | 0.9454 | 0.8792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3822 | -1.742 | 0.9146 | -0.04263 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2425 | -0.3771 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 479.13244 | 1.004 | -1.432 | -0.9368 | -0.9184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.101 | -1.061 | -0.1790 | -0.9224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7372 | -1.105 | -0.5036 | -0.8775 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04025 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.13244 | 91.33 | -5.632 | -0.9135 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.714 | 0.3778 | 1.119 | 0.05708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8331 | 0.6941 | 1.614 | 0.9502 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6825 | 2.218 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.13244</span> | 91.33 | 0.003580 | 0.2863 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008971 | 0.5933 | 1.119 | 0.05708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8331 | 0.6941 | 1.614 | 0.9502 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6825 | 2.218 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.808 | 0.6219 | -0.1958 | -0.01683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2369 | -0.2179 | 0.9347 | 0.8364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3987 | -1.797 | 0.8150 | -0.05765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2618 | -0.3704 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 479.12666 | 1.004 | -1.434 | -0.9365 | -0.9183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.102 | -1.060 | -0.1796 | -0.9220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7365 | -1.104 | -0.5033 | -0.8772 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.12666 | 91.40 | -5.634 | -0.9132 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.714 | 0.3782 | 1.118 | 0.05709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8336 | 0.6951 | 1.614 | 0.9505 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.218 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.12666</span> | 91.40 | 0.003574 | 0.2863 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008965 | 0.5934 | 1.118 | 0.05709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8336 | 0.6951 | 1.614 | 0.9505 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.218 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.9955 | 0.6218 | -0.09617 | -0.02448 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2342 | -0.2176 | 0.9924 | 0.8560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3772 | -1.645 | 1.883 | -0.4422 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1320 | -0.3750 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 479.12255 | 1.004 | -1.436 | -0.9361 | -0.9182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.103 | -1.060 | -0.1805 | -0.9221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7358 | -1.103 | -0.5043 | -0.8768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03920 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.12255 | 91.34 | -5.636 | -0.9129 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.715 | 0.3784 | 1.118 | 0.05709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 0.6962 | 1.613 | 0.9509 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.12255</span> | 91.34 | 0.003569 | 0.2864 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008960 | 0.5935 | 1.118 | 0.05709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 0.6962 | 1.613 | 0.9509 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.522 | 0.6133 | -0.1571 | -0.01492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2353 | -0.1923 | 0.9045 | 0.7846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3572 | -1.629 | 0.8508 | 0.03564 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2811 | -0.3561 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 479.11855 | 1.005 | -1.437 | -0.9356 | -0.9182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.103 | -1.059 | -0.1812 | -0.9217 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7351 | -1.102 | -0.5043 | -0.8766 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03859 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.11855 | 91.41 | -5.637 | -0.9124 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.716 | 0.3787 | 1.118 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 0.6968 | 1.613 | 0.9510 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11855</span> | 91.41 | 0.003562 | 0.2865 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008953 | 0.5936 | 1.118 | 0.05710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 0.6968 | 1.613 | 0.9510 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.813 | 0.6131 | -0.03713 | -0.02450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2319 | -0.1976 | 0.8863 | 0.8390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3589 | -1.516 | 0.8806 | -0.4426 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1647 | -0.3784 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 479.11487 | 1.004 | -1.439 | -0.9352 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.104 | -1.058 | -0.1819 | -0.9213 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7344 | -1.101 | -0.5040 | -0.8763 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03810 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.11487 | 91.37 | -5.639 | -0.9121 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.716 | 0.3790 | 1.117 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8352 | 0.6977 | 1.613 | 0.9514 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11487</span> | 91.37 | 0.003555 | 0.2866 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008947 | 0.5936 | 1.117 | 0.05711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8352 | 0.6977 | 1.613 | 0.9514 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.684 | 0.6054 | -0.08346 | -0.01559 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2328 | -0.1708 | 0.9518 | 0.8099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3621 | -1.485 | 0.9267 | -0.3776 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1041 | -0.3537 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 479.11139 | 1.005 | -1.441 | -0.9347 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.105 | -1.058 | -0.1829 | -0.9211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7337 | -1.100 | -0.5039 | -0.8760 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03771 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.11139 | 91.41 | -5.641 | -0.9117 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.717 | 0.3792 | 1.117 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8357 | 0.6988 | 1.613 | 0.9517 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.221 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11139</span> | 91.41 | 0.003549 | 0.2867 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008941 | 0.5937 | 1.117 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8357 | 0.6988 | 1.613 | 0.9517 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.221 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.241 | 0.6036 | 0.0009951 | -0.02154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2300 | -0.1727 | 0.8524 | 0.8311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3642 | -1.386 | 1.866 | -0.3472 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1024 | -0.3634 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 479.10851 | 1.004 | -1.443 | -0.9342 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.105 | -1.058 | -0.1837 | -0.9207 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7329 | -1.100 | -0.5043 | -0.8759 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03710 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.10851 | 91.37 | -5.643 | -0.9112 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.718 | 0.3794 | 1.117 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.6988 | 1.613 | 0.9517 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.222 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10851</span> | 91.37 | 0.003542 | 0.2868 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008933 | 0.5937 | 1.117 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.6988 | 1.613 | 0.9517 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.222 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.500 | 0.5956 | -0.03344 | -0.01385 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2306 | -0.1498 | 0.8910 | 0.8240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3570 | -1.405 | 0.8461 | -0.3572 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.08808 | -0.3487 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 479.10606 | 1.005 | -1.445 | -0.9338 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.106 | -1.057 | -0.1846 | -0.9207 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7320 | -1.099 | -0.5047 | -0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03650 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.10606 | 91.43 | -5.645 | -0.9108 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.719 | 0.3796 | 1.116 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8369 | 0.6994 | 1.612 | 0.9519 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6822 | 2.222 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10606</span> | 91.43 | 0.003535 | 0.2868 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008927 | 0.5938 | 1.116 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8369 | 0.6994 | 1.612 | 0.9519 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6822 | 2.222 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.260 | 0.5953 | 0.07226 | -0.02302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2275 | -0.1573 | 0.8150 | 0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3410 | -1.340 | 0.8208 | 0.1422 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2750 | -0.3500 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 479.10199 | 1.004 | -1.447 | -0.9337 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.107 | -1.057 | -0.1854 | -0.9204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7311 | -1.099 | -0.5045 | -0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03604 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.10199 | 91.37 | -5.647 | -0.9107 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.720 | 0.3799 | 1.116 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8375 | 0.6999 | 1.613 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6821 | 2.223 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10199</span> | 91.37 | 0.003528 | 0.2869 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008919 | 0.5938 | 1.116 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8375 | 0.6999 | 1.613 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6821 | 2.223 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7698 | 0.5858 | -0.004343 | -0.01418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2278 | -0.1298 | 0.8244 | 0.7686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3575 | -1.372 | 0.8320 | -0.3359 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2977 | -0.3384 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 479.09844 | 1.005 | -1.448 | -0.9337 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.108 | -1.056 | -0.1863 | -0.9208 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7304 | -1.097 | -0.5051 | -0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03534 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.09844 | 91.43 | -5.648 | -0.9108 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.720 | 0.3801 | 1.116 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8381 | 0.7011 | 1.612 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6817 | 2.224 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09844</span> | 91.43 | 0.003523 | 0.2868 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008914 | 0.5939 | 1.116 | 0.05713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8381 | 0.7011 | 1.612 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6817 | 2.224 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.894 | 0.5851 | 0.05981 | -0.02077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2261 | -0.1389 | 0.7622 | 0.7617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3411 | -1.236 | 0.7863 | 0.1583 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2091 | -0.3951 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 479.09485 | 1.004 | -1.450 | -0.9338 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.108 | -1.056 | -0.1867 | -0.9202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7295 | -1.097 | -0.5051 | -0.8750 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03445 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.09485 | 91.37 | -5.650 | -0.9108 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.721 | 0.3803 | 1.116 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8388 | 0.7016 | 1.612 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6813 | 2.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09485</span> | 91.37 | 0.003517 | 0.2868 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008907 | 0.5939 | 1.116 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8388 | 0.7016 | 1.612 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6813 | 2.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.077 | 0.5762 | -0.02502 | -0.01122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2275 | -0.1137 | 0.7953 | 0.7347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3473 | -1.249 | 0.8683 | 0.1895 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2333 | -0.3625 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 479.09211 | 1.005 | -1.452 | -0.9337 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.109 | -1.055 | -0.1878 | -0.9202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7286 | -1.096 | -0.5055 | -0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03372 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.09211 | 91.41 | -5.652 | -0.9107 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.722 | 0.3805 | 1.115 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8394 | 0.7021 | 1.612 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09211</span> | 91.41 | 0.003510 | 0.2868 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008900 | 0.5940 | 1.115 | 0.05714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8394 | 0.7021 | 1.612 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.651 | 0.5754 | 0.04071 | -0.01634 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2261 | -0.1150 | 0.8084 | 0.7089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3268 | -1.156 | 0.8610 | 0.1793 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2137 | -0.3471 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 479.08947 | 1.004 | -1.454 | -0.9335 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.110 | -1.055 | -0.1890 | -0.9199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7277 | -1.096 | -0.5056 | -0.8754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03307 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.08947 | 91.37 | -5.654 | -0.9105 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.722 | 0.3808 | 1.115 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8401 | 0.7021 | 1.611 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6809 | 2.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08947</span> | 91.37 | 0.003504 | 0.2869 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008893 | 0.5941 | 1.115 | 0.05715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8401 | 0.7021 | 1.611 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6809 | 2.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8529 | 0.5679 | -0.006947 | -0.009666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2263 | -0.09399 | 0.7582 | 0.6848 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3382 | -1.232 | 0.7736 | -0.3452 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1950 | -0.3796 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 479.08673 | 1.005 | -1.456 | -0.9331 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.111 | -1.054 | -0.1901 | -0.9198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7269 | -1.095 | -0.5060 | -0.8751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03242 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.08673 | 91.42 | -5.656 | -0.9102 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.723 | 0.3808 | 1.114 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8406 | 0.7030 | 1.611 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.227 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08673</span> | 91.42 | 0.003498 | 0.2870 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008887 | 0.5941 | 1.114 | 0.05716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8406 | 0.7030 | 1.611 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.227 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.055 | 0.5667 | 0.07240 | -0.01542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2241 | -0.1033 | 0.7160 | 0.6904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3260 | -1.123 | 0.7675 | 0.1856 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1986 | -0.4973 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 479.08385 | 1.004 | -1.457 | -0.9328 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.112 | -1.054 | -0.1908 | -0.9191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7261 | -1.095 | -0.5059 | -0.8749 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03140 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.08385 | 91.37 | -5.657 | -0.9100 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.724 | 0.3808 | 1.114 | 0.05718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8412 | 0.7034 | 1.611 | 0.9527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6808 | 2.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08385</span> | 91.37 | 0.003491 | 0.2870 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008879 | 0.5941 | 1.114 | 0.05718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8412 | 0.7034 | 1.611 | 0.9527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6808 | 2.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7735 | 0.5583 | 0.01997 | -0.008335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2243 | -0.08958 | 0.6952 | 0.6337 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3199 | -1.102 | 0.8222 | 0.2014 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2310 | -0.4538 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 479.08143 | 1.005 | -1.459 | -0.9328 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.112 | -1.054 | -0.1918 | -0.9191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7254 | -1.094 | -0.5066 | -0.8749 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.03018 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.08143 | 91.42 | -5.659 | -0.9100 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.725 | 0.3810 | 1.113 | 0.05718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8417 | 0.7042 | 1.610 | 0.9527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6804 | 2.230 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08143</span> | 91.42 | 0.003486 | 0.2870 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008874 | 0.5941 | 1.113 | 0.05718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8417 | 0.7042 | 1.610 | 0.9527 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6804 | 2.230 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.589 | 0.5568 | 0.08446 | -0.01637 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2217 | -0.09943 | 0.6530 | 0.6713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3160 | -1.044 | 0.6971 | -0.3035 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2323 | -0.3746 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 479.07858 | 1.004 | -1.461 | -0.9326 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.113 | -1.054 | -0.1923 | -0.9184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7246 | -1.093 | -0.5066 | -0.8747 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.02916 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.07858 | 91.36 | -5.661 | -0.9098 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.725 | 0.3811 | 1.113 | 0.05720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8423 | 0.7045 | 1.610 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6802 | 2.231 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07858</span> | 91.36 | 0.003479 | 0.2870 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008866 | 0.5941 | 1.113 | 0.05720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8423 | 0.7045 | 1.610 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6802 | 2.231 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.147 | 0.5485 | 0.01974 | -0.006990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2231 | -0.08394 | 0.6583 | 0.6424 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3232 | -1.114 | 0.8219 | 0.1886 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1911 | -0.3375 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 479.07618 | 1.004 | -1.463 | -0.9323 | -0.9182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.114 | -1.054 | -0.1929 | -0.9181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7237 | -1.093 | -0.5068 | -0.8746 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.02850 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.07618 | 91.40 | -5.663 | -0.9095 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.726 | 0.3811 | 1.113 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 0.7050 | 1.610 | 0.9530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6800 | 2.232 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07618</span> | 91.40 | 0.003472 | 0.2871 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008858 | 0.5941 | 1.113 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 0.7050 | 1.610 | 0.9530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6800 | 2.232 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.586 | 0.5458 | 0.07904 | -0.01251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2203 | -0.08960 | 0.6458 | 0.6586 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3031 | -0.9906 | 0.7687 | 0.2646 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1721 | -0.3284 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 479.07405 | 1.004 | -1.465 | -0.9322 | -0.9183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.115 | -1.053 | -0.1937 | -0.9179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7228 | -1.093 | -0.5070 | -0.8747 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02798 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.07405 | 91.36 | -5.665 | -0.9094 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.727 | 0.3813 | 1.113 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8437 | 0.7050 | 1.610 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6797 | 2.233 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07405</span> | 91.36 | 0.003465 | 0.2871 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008850 | 0.5942 | 1.113 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8437 | 0.7050 | 1.610 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6797 | 2.233 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.296 | 0.5389 | 0.03360 | -0.006173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2208 | -0.07255 | 0.6853 | 0.5995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2906 | -1.015 | 0.7685 | 0.2327 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1765 | -0.3245 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 479.07209 | 1.004 | -1.467 | -0.9321 | -0.9183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.116 | -1.053 | -0.1949 | -0.9178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7220 | -1.093 | -0.5073 | -0.8750 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02746 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.07209 | 91.39 | -5.667 | -0.9093 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.728 | 0.3814 | 1.112 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8442 | 0.7050 | 1.609 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6796 | 2.233 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07209</span> | 91.39 | 0.003458 | 0.2871 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008841 | 0.5942 | 1.112 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8442 | 0.7050 | 1.609 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6796 | 2.233 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.160 | 0.5372 | 0.08826 | -0.01153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2184 | -0.07756 | 0.6386 | 0.6404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2977 | -0.9812 | 0.7463 | 0.2047 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1647 | -0.3238 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 479.07029 | 1.004 | -1.469 | -0.9320 | -0.9184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.117 | -1.053 | -0.1960 | -0.9175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7213 | -1.093 | -0.5075 | -0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02689 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.07029 | 91.35 | -5.669 | -0.9092 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.729 | 0.3815 | 1.112 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8447 | 0.7049 | 1.609 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6795 | 2.234 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07029</span> | 91.35 | 0.003451 | 0.2872 | 0.1130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008833 | 0.5942 | 1.112 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8447 | 0.7049 | 1.609 | 0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6795 | 2.234 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.487 | 0.5301 | 0.04502 | -0.006786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2180 | -0.06576 | 0.6433 | 0.5523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2822 | -1.039 | 1.637 | -0.2973 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2152 | -0.3175 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 479.06833 | 1.004 | -1.471 | -0.9316 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1965 | -0.9170 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7207 | -1.093 | -0.5082 | -0.8751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02616 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.06833 | 91.38 | -5.671 | -0.9088 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.730 | 0.3814 | 1.111 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8452 | 0.7048 | 1.608 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6792 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06833</span> | 91.38 | 0.003444 | 0.2872 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008825 | 0.5942 | 1.111 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8452 | 0.7048 | 1.608 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6792 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.6466 | 0.5255 | 0.09166 | -0.01288 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2142 | -0.07904 | 0.5622 | 0.5865 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2779 | -1.008 | 0.7011 | 0.1998 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1404 | -0.3181 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 479.06868 | 1.003 | -1.472 | -0.9317 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1973 | -0.9180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7202 | -1.092 | -0.5093 | -0.8754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02567 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.06868 | 91.29 | -5.672 | -0.9090 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.731 | 0.3814 | 1.111 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8455 | 0.7062 | 1.607 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06868</span> | 91.29 | 0.003441 | 0.2872 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008822 | 0.5942 | 1.111 | 0.05721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8455 | 0.7062 | 1.607 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 479.06735 | 1.004 | -1.472 | -0.9316 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1969 | -0.9175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7205 | -1.092 | -0.5087 | -0.8753 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02593 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.06735 | 91.33 | -5.672 | -0.9089 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.730 | 0.3814 | 1.111 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 0.7054 | 1.608 | 0.9523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6791 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06735</span> | 91.33 | 0.003443 | 0.2872 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008823 | 0.5942 | 1.111 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 0.7054 | 1.608 | 0.9523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6791 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.476 | 0.5223 | 0.03269 | -0.003763 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2173 | -0.06616 | 0.5281 | 0.5229 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3041 | -1.023 | 1.607 | -0.2773 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2325 | -0.3192 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 479.06543 | 1.004 | -1.472 | -0.9319 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1968 | -0.9175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7201 | -1.092 | -0.5088 | -0.8751 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -0.02567 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.06543 | 91.36 | -5.672 | -0.9091 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.731 | 0.3815 | 1.111 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8456 | 0.7056 | 1.608 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06543</span> | 91.36 | 0.003439 | 0.2872 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008820 | 0.5942 | 1.111 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8456 | 0.7056 | 1.608 | 0.9525 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 479.06390 | 1.004 | -1.474 | -0.9324 | -0.9185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.119 | -1.053 | -0.1965 | -0.9174 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7194 | -1.092 | -0.5089 | -0.8750 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -0.02528 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.0639 | 91.36 | -5.674 | -0.9095 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.732 | 0.3816 | 1.111 | 0.05723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8461 | 0.7059 | 1.607 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6786 | 2.236 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.0639</span> | 91.36 | 0.003434 | 0.2871 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008813 | 0.5943 | 1.111 | 0.05723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8461 | 0.7059 | 1.607 | 0.9526 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6786 | 2.236 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 479.05708 | 1.004 | -1.481 | -0.9346 | -0.9186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.123 | -1.051 | -0.1952 | -0.9171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7164 | -1.090 | -0.5089 | -0.8741 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.090 | -0.02338 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.05708 | 91.37 | -5.681 | -0.9115 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.735 | 0.3824 | 1.112 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8483 | 0.7072 | 1.607 | 0.9535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6769 | 2.238 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.05708</span> | 91.37 | 0.003409 | 0.2867 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008783 | 0.5944 | 1.112 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8483 | 0.7072 | 1.607 | 0.9535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6769 | 2.238 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 479.03987 | 1.004 | -1.510 | -0.9434 | -0.9188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.136 | -1.045 | -0.1899 | -0.9157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7043 | -1.085 | -0.5092 | -0.8705 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.098 | -0.01577 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.03987 | 91.37 | -5.710 | -0.9193 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.749 | 0.3852 | 1.114 | 0.05728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8571 | 0.7123 | 1.607 | 0.9569 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6702 | 2.247 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.03987</span> | 91.37 | 0.003311 | 0.2851 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008662 | 0.5951 | 1.114 | 0.05728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8571 | 0.7123 | 1.607 | 0.9569 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6702 | 2.247 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3651 | 0.4285 | -0.5283 | -0.001988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1991 | 0.06799 | 0.8278 | 0.7155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2362 | -0.3851 | 0.6274 | 0.1204 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9270 | -0.3308 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 139</span>| 479.01407 | 1.005 | -1.553 | -0.9371 | -0.9187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.158 | -1.041 | -0.1978 | -0.9162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6881 | -1.086 | -0.5088 | -0.8721 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.097 | -0.01436 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.01407 | 91.44 | -5.753 | -0.9138 | -2.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.770 | 0.3869 | 1.111 | 0.05726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8690 | 0.7117 | 1.608 | 0.9554 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6704 | 2.249 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.01407</span> | 91.44 | 0.003172 | 0.2862 | 0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008479 | 0.5955 | 1.111 | 0.05726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8690 | 0.7117 | 1.608 | 0.9554 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6704 | 2.249 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.322 | 0.3385 | -0.09736 | -0.005783 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1607 | 0.1322 | 0.5556 | 0.5176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1562 | -0.2690 | 1.549 | -0.03161 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8578 | -0.3240 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 140</span>| 478.99946 | 1.003 | -1.595 | -0.9294 | -0.9194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.179 | -1.045 | -0.1992 | -0.9136 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6715 | -1.093 | -0.5132 | -0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.009543 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.99946 | 91.31 | -5.795 | -0.9069 | -2.182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.791 | 0.3851 | 1.110 | 0.05734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8811 | 0.7049 | 1.602 | 0.9551 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6678 | 2.255 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99946</span> | 91.31 | 0.003042 | 0.2876 | 0.1128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008303 | 0.5951 | 1.110 | 0.05734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8811 | 0.7049 | 1.602 | 0.9551 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6678 | 2.255 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.440 | 0.2525 | 0.1677 | 0.001517 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1272 | 0.05864 | 0.6253 | 0.4352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1457 | -0.7321 | 1.353 | 0.0009973 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.018 | -0.3498 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 141</span>| 479.00064 | 1.004 | -1.626 | -0.9429 | -0.9240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.201 | -1.064 | -0.2165 | -0.9169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6612 | -1.100 | -0.5189 | -0.8809 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.001744 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.00064 | 91.38 | -5.826 | -0.9189 | -2.186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.814 | 0.3763 | 1.103 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8887 | 0.6986 | 1.596 | 0.9470 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6683 | 2.264 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.00064</span> | 91.38 | 0.002950 | 0.2852 | 0.1123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008117 | 0.5930 | 1.103 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8887 | 0.6986 | 1.596 | 0.9470 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6683 | 2.264 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 142</span>| 478.99385 | 1.004 | -1.610 | -0.9359 | -0.9216 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.190 | -1.054 | -0.2077 | -0.9152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6665 | -1.096 | -0.5161 | -0.8765 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.005738 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.99385 | 91.39 | -5.810 | -0.9127 | -2.184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.802 | 0.3808 | 1.107 | 0.05729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8848 | 0.7019 | 1.599 | 0.9512 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6681 | 2.260 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99385</span> | 91.39 | 0.002997 | 0.2864 | 0.1126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008212 | 0.5941 | 1.107 | 0.05729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8848 | 0.7019 | 1.599 | 0.9512 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6681 | 2.260 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.499 | 0.2382 | -0.03703 | -0.03958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09629 | -0.2111 | 0.3210 | 0.2393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1233 | -0.7892 | 1.126 | -0.4047 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.051 | -0.3984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 143</span>| 478.98455 | 1.004 | -1.625 | -0.9347 | -0.9200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.200 | -1.054 | -0.2131 | -0.9088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6653 | -1.094 | -0.5167 | -0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.099 | 0.008183 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.98455 | 91.36 | -5.825 | -0.9116 | -2.182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.813 | 0.3812 | 1.105 | 0.05748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8857 | 0.7042 | 1.598 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6689 | 2.277 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.98455</span> | 91.36 | 0.002951 | 0.2867 | 0.1128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008125 | 0.5942 | 1.105 | 0.05748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8857 | 0.7042 | 1.598 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6689 | 2.277 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2799 | 0.1926 | -0.02074 | -0.02333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08052 | -0.1468 | 0.2817 | 0.3348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1470 | -0.6425 | 1.062 | -0.3208 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8181 | -0.3186 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 144</span>| 478.97736 | 1.005 | -1.639 | -0.9325 | -0.9174 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.210 | -1.043 | -0.2100 | -0.9166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6557 | -1.093 | -0.5206 | -0.8754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.097 | 0.01446 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97736 | 91.42 | -5.839 | -0.9097 | -2.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.822 | 0.3861 | 1.106 | 0.05725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8927 | 0.7053 | 1.594 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6711 | 2.284 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97736</span> | 91.42 | 0.002912 | 0.2871 | 0.1131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008047 | 0.5953 | 1.106 | 0.05725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8927 | 0.7053 | 1.594 | 0.9522 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6711 | 2.284 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.719 | 0.1644 | 0.1764 | 0.0002018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06754 | 0.1935 | -0.08189 | -0.1310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08678 | -2.826 | 0.8338 | -0.2552 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4561 | -0.1956 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 145</span>| 478.97194 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.087 | -0.5238 | -0.8740 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01749 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97194 | 91.40 | -5.852 | -0.9078 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97194</span> | 91.40 | 0.002874 | 0.2875 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.925 | 0.1117 | 0.2312 | 0.02461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04286 | 0.3818 | 0.1548 | -0.1592 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04325 | -0.1382 | 0.7430 | -0.2262 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.01070 | -0.1316 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 146</span>| 479.08778 | 0.9990 | -1.662 | -0.9298 | -0.9158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.224 | -1.050 | -0.2095 | -0.9175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6325 | -1.087 | -0.5258 | -0.8715 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.094 | 0.02816 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.08778 | 90.91 | -5.862 | -0.9073 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.836 | 0.3828 | 1.106 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9096 | 0.7103 | 1.587 | 0.9559 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6733 | 2.301 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08778</span> | 90.91 | 0.002845 | 0.2876 | 0.1132 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007936 | 0.5946 | 1.106 | 0.05722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9096 | 0.7103 | 1.587 | 0.9559 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6733 | 2.301 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 147</span>| 478.99303 | 1.002 | -1.652 | -0.9306 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2045 | -0.9253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.087 | -0.5244 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01760 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.99303 | 91.18 | -5.852 | -0.9080 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7107 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99303</span> | 91.18 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7107 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 148</span>| 478.97158 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.087 | -0.5239 | -0.8740 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01751 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97158 | 91.37 | -5.852 | -0.9078 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97158</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1518 | 0.1094 | 0.1916 | 0.02921 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04385 | 0.3896 | -0.2077 | -0.4379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03471 | -2.421 | 0.7262 | -0.1589 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01110 | -0.1305 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 149</span>| 478.97152 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.086 | -0.5240 | -0.8739 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01753 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97152 | 91.37 | -5.852 | -0.9078 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7109 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97152</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7109 | 1.590 | 0.9536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.2246 | 0.1050 | 0.1574 | 0.02036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04103 | 0.3470 | -0.3387 | -0.1919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1172 | -0.1870 | 0.6243 | -0.2341 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.06769 | -0.1265 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 150</span>| 478.97142 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2042 | -0.9253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5242 | -0.8739 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01757 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97142 | 91.38 | -5.852 | -0.9079 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97142</span> | 91.38 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.5593 | 0.1052 | 0.1640 | 0.01900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04052 | 0.3419 | -0.3227 | -0.1646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1158 | -0.1768 | 0.1839 | -0.2151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04116 | -0.1006 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 151</span>| 478.97143 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5243 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01761 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97143 | 91.36 | -5.852 | -0.9079 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97143</span> | 91.36 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 152</span>| 478.97137 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2042 | -0.9253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5242 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01759 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97137 | 91.37 | -5.852 | -0.9079 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97137</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.4660 | 0.1043 | 0.1497 | 0.02048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04080 | 0.3434 | -0.3050 | -0.1804 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2015 | -1.954 | 0.1460 | -0.2263 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03239 | -0.1147 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 153</span>| 478.97135 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -1.086 | -0.5242 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01760 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97135 | 91.36 | -5.852 | -0.9079 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7110 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97135</span> | 91.36 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7110 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.8144 | 0.1038 | 0.1446 | 0.02101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04083 | 0.3431 | -0.3133 | -0.1844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05440 | -1.096 | 0.1463 | -0.2004 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2780 | -0.1269 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 154</span>| 478.97125 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -1.086 | -0.5243 | -0.8738 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01762 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97125 | 91.37 | -5.852 | -0.9079 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7111 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97125</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7111 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.03985 | 0.1039 | 0.1540 | 0.01970 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04056 | 0.3392 | -0.3415 | -0.1666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1386 | -0.1574 | 0.08901 | -0.2003 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04000 | -0.1187 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 155</span>| 478.97118 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2040 | -0.9252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6440 | -1.086 | -0.5243 | -0.8737 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01765 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97118 | 91.37 | -5.852 | -0.9080 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3878 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97118</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.05720 | 0.1036 | 0.1507 | 0.01972 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04048 | 0.3375 | -0.2940 | -0.1684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1979 | -1.920 | 0.1339 | -0.2027 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04399 | -0.1216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 156</span>| 478.97118 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2040 | -0.9252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6440 | -1.086 | -0.5243 | -0.8737 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01765 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.97118 | 91.37 | -5.852 | -0.9080 | -2.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3878 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97118</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance, can check sandwich or S matrix with $covRS and $covS</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Two-component error by variable is possible with both estimation methods</span></span> +<span class="r-in"><span class="co"># Variance by variable is supported by 'saem' and 'focei'</span></span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_saem_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> 1: 92.0624 -5.2854 0.1952 1.9494 -1.9431 2.8500 1.6150 0.7315 0.7220 0.4370 6.8425 0.4265 7.3797 0.5659</span> +<span class="r-out co"><span class="r-pr">#></span> 2: 92.7371 -5.3819 0.0345 2.0839 -2.0310 2.7075 1.5342 0.6949 0.8358 0.4151 7.2043 0.0003 8.1096 0.0003</span> +<span class="r-out co"><span class="r-pr">#></span> 3: 9.2941e+01 -5.7880e+00 1.0336e-01 2.5772e+00 -1.5152e+00 2.5721e+00 1.4575e+00 6.6018e-01 7.9403e-01 3.9439e-01 4.5749e+00 1.5986e-05 5.1354e+00 2.8796e-05</span> +<span class="r-out co"><span class="r-pr">#></span> 4: 92.6277 -5.8599 0.0858 2.5068 -1.3253 2.4435 1.3847 0.6272 0.7543 0.3747 3.4165 0.0001 3.9071 0.0016</span> +<span class="r-out co"><span class="r-pr">#></span> 5: 93.0289 -6.0258 0.0528 2.4932 -1.1961 2.3213 1.3154 0.5958 0.7166 0.3559 3.2552 0.0069 3.3744 0.0170</span> +<span class="r-out co"><span class="r-pr">#></span> 6: 93.2107 -6.2881 0.0143 2.4052 -1.1930 2.2053 2.2853 0.5660 0.6808 0.3381 2.8020 0.0086 3.1436 0.0256</span> +<span class="r-out co"><span class="r-pr">#></span> 7: 93.0563 -6.3624 -0.0104 2.3989 -1.1521 2.0950 2.4414 0.5377 0.6467 0.3212 2.6528 0.0209 2.8462 0.0289</span> +<span class="r-out co"><span class="r-pr">#></span> 8: 93.0567 -6.2699 -0.0303 2.3700 -1.0941 1.9903 2.5004 0.5204 0.6144 0.3052 2.3448 0.0314 2.5026 0.0349</span> +<span class="r-out co"><span class="r-pr">#></span> 9: 92.8366 -6.2013 -0.0507 2.3798 -1.0963 1.8907 2.6552 0.4943 0.5837 0.2899 2.2219 0.0368 2.2604 0.0448</span> +<span class="r-out co"><span class="r-pr">#></span> 10: 92.9069 -6.2499 -0.1116 2.3100 -1.0557 1.9625 3.9231 0.4696 0.5545 0.2754 2.0980 0.0359 2.1413 0.0325</span> +<span class="r-out co"><span class="r-pr">#></span> 11: 92.9942 -6.2134 -0.1037 2.3109 -1.0441 1.8643 3.7270 0.4755 0.5268 0.2616 1.9711 0.0372 1.9901 0.0355</span> +<span class="r-out co"><span class="r-pr">#></span> 12: 92.9262 -6.2511 -0.1133 2.2707 -1.0465 1.8430 4.3304 0.4697 0.5004 0.2486 1.8083 0.0346 1.9184 0.0356</span> +<span class="r-out co"><span class="r-pr">#></span> 13: 93.0761 -6.3559 -0.1106 2.2534 -1.0162 2.4826 5.2857 0.4685 0.4754 0.2361 1.7896 0.0331 1.9865 0.0342</span> +<span class="r-out co"><span class="r-pr">#></span> 14: 93.0929 -6.1852 -0.1058 2.2972 -1.0175 2.9964 5.0214 0.4451 0.4516 0.2243 1.8316 0.0309 1.9112 0.0348</span> +<span class="r-out co"><span class="r-pr">#></span> 15: 93.3343 -6.3408 -0.1025 2.2905 -0.9962 3.1132 4.9630 0.4594 0.4291 0.2131 1.8198 0.0338 1.9154 0.0372</span> +<span class="r-out co"><span class="r-pr">#></span> 16: 92.9959 -6.2227 -0.1016 2.2869 -1.0103 3.3338 4.7149 0.4598 0.4076 0.2025 1.8726 0.0327 1.9617 0.0361</span> +<span class="r-out co"><span class="r-pr">#></span> 17: 93.0394 -6.2586 -0.1027 2.2932 -0.9991 3.1671 4.8730 0.4591 0.3872 0.1923 1.8405 0.0336 2.0192 0.0242</span> +<span class="r-out co"><span class="r-pr">#></span> 18: 93.2374 -6.3410 -0.1110 2.2965 -0.9689 3.0087 5.4325 0.4632 0.3679 0.1827 1.9051 0.0351 1.9247 0.0277</span> +<span class="r-out co"><span class="r-pr">#></span> 19: 93.0557 -6.4503 -0.1011 2.2941 -0.9884 2.8583 6.2872 0.4742 0.3495 0.1736 1.8054 0.0345 1.9173 0.0260</span> +<span class="r-out co"><span class="r-pr">#></span> 20: 92.9280 -6.4945 -0.1018 2.2902 -0.9864 3.5934 6.8737 0.4751 0.3320 0.1649 1.7097 0.0372 1.9483 0.0225</span> +<span class="r-out co"><span class="r-pr">#></span> 21: 93.2023 -6.3418 -0.1033 2.2846 -0.9863 3.4138 6.5300 0.4710 0.3154 0.1567 1.7507 0.0318 1.9030 0.0249</span> +<span class="r-out co"><span class="r-pr">#></span> 22: 93.5494 -6.1985 -0.1078 2.2991 -1.0171 3.2431 6.2035 0.4475 0.2996 0.1488 1.7370 0.0342 1.8124 0.0282</span> +<span class="r-out co"><span class="r-pr">#></span> 23: 93.3588 -6.2577 -0.1084 2.2654 -0.9956 3.0809 5.8933 0.4393 0.2869 0.1481 1.6928 0.0380 1.8288 0.0254</span> +<span class="r-out co"><span class="r-pr">#></span> 24: 93.5705 -6.4876 -0.1083 2.2606 -1.0062 3.7095 6.7801 0.4459 0.2726 0.1684 1.7001 0.0377 1.9012 0.0249</span> +<span class="r-out co"><span class="r-pr">#></span> 25: 93.9726 -6.5638 -0.1239 2.2374 -1.0071 5.1357 6.6571 0.4608 0.2755 0.1600 1.6615 0.0382 1.8846 0.0213</span> +<span class="r-out co"><span class="r-pr">#></span> 26: 93.8894 -6.5073 -0.1120 2.2645 -1.0327 4.8789 6.3243 0.4473 0.3014 0.1520 1.7152 0.0340 1.8990 0.0254</span> +<span class="r-out co"><span class="r-pr">#></span> 27: 94.5348 -6.3868 -0.0891 2.3139 -1.0361 5.3856 6.0081 0.4250 0.3080 0.1453 1.7028 0.0385 1.7853 0.0304</span> +<span class="r-out co"><span class="r-pr">#></span> 28: 93.9221 -6.1747 -0.1039 2.3013 -1.0087 5.1163 5.7077 0.4214 0.3136 0.1634 1.6823 0.0340 1.7487 0.0353</span> +<span class="r-out co"><span class="r-pr">#></span> 29: 93.4946 -6.0264 -0.0940 2.3124 -1.0166 5.3744 5.4223 0.4404 0.3114 0.1813 1.6310 0.0370 1.7646 0.0367</span> +<span class="r-out co"><span class="r-pr">#></span> 30: 93.9287 -5.9114 -0.0967 2.3078 -1.0090 5.2017 5.1512 0.4381 0.3048 0.2091 1.5825 0.0393 1.7431 0.0312</span> +<span class="r-out co"><span class="r-pr">#></span> 31: 93.7065 -6.0174 -0.0928 2.2917 -0.9880 5.1935 4.8936 0.4352 0.3109 0.1986 1.5876 0.0392 1.8465 0.0280</span> +<span class="r-out co"><span class="r-pr">#></span> 32: 93.7675 -5.6444 -0.0918 2.3145 -0.9664 4.9338 4.6489 0.4332 0.3090 0.1918 1.6874 0.0332 1.7501 0.0331</span> +<span class="r-out co"><span class="r-pr">#></span> 33: 94.2589 -5.7637 -0.0865 2.3130 -0.9733 4.6871 4.4165 0.4235 0.2935 0.1865 1.7173 0.0355 1.7365 0.0334</span> +<span class="r-out co"><span class="r-pr">#></span> 34: 94.0788 -5.7432 -0.1022 2.3049 -0.9681 4.4528 4.1957 0.4319 0.2962 0.1772 1.6357 0.0361 1.4755 0.0574</span> +<span class="r-out co"><span class="r-pr">#></span> 35: 94.0798 -5.8549 -0.0929 2.2856 -0.9849 4.2301 3.9859 0.4391 0.2937 0.1734 1.6460 0.0275 1.7739 0.0379</span> +<span class="r-out co"><span class="r-pr">#></span> 36: 93.9997 -5.8708 -0.0890 2.2870 -1.0134 4.0186 3.7866 0.4268 0.2819 0.1840 1.5830 0.0258 1.8922 0.0320</span> +<span class="r-out co"><span class="r-pr">#></span> 37: 93.8186 -5.8979 -0.0973 2.2807 -1.0197 3.8177 3.5973 0.4280 0.2778 0.1799 1.5783 0.0282 1.7697 0.0404</span> +<span class="r-out co"><span class="r-pr">#></span> 38: 94.0728 -5.9601 -0.0936 2.3011 -1.0381 3.6268 3.4174 0.4186 0.2944 0.1864 1.5780 0.0294 1.5210 0.0558</span> +<span class="r-out co"><span class="r-pr">#></span> 39: 94.0504 -5.8302 -0.0995 2.2847 -1.0418 3.4455 3.2465 0.4240 0.2796 0.1771 1.6888 0.0242 1.7744 0.0366</span> +<span class="r-out co"><span class="r-pr">#></span> 40: 93.8918 -5.9418 -0.0988 2.2925 -1.0613 3.2732 3.0842 0.4144 0.2672 0.1837 1.7275 0.0232 1.7840 0.0357</span> +<span class="r-out co"><span class="r-pr">#></span> 41: 93.7961 -6.0741 -0.0896 2.2932 -1.0359 3.1095 3.2890 0.4236 0.2606 0.1782 1.7591 0.0212 1.8920 0.0273</span> +<span class="r-out co"><span class="r-pr">#></span> 42: 93.9458 -6.0319 -0.0909 2.3114 -1.0281 3.0544 3.1246 0.4196 0.2598 0.1839 1.6854 0.0310 1.7586 0.0308</span> +<span class="r-out co"><span class="r-pr">#></span> 43: 93.7623 -6.0165 -0.1056 2.2837 -1.0378 3.9092 3.2100 0.4298 0.2468 0.1747 1.7064 0.0286 1.6676 0.0397</span> +<span class="r-out co"><span class="r-pr">#></span> 44: 93.4300 -5.9019 -0.1114 2.2716 -1.0167 4.4100 3.0495 0.4476 0.2345 0.1687 1.7989 0.0253 1.7741 0.0299</span> +<span class="r-out co"><span class="r-pr">#></span> 45: 93.3475 -5.9962 -0.1231 2.2546 -1.0007 6.4879 3.3965 0.4528 0.2452 0.1602 1.7283 0.0276 1.7219 0.0379</span> +<span class="r-out co"><span class="r-pr">#></span> 46: 93.3100 -6.0073 -0.1255 2.2483 -0.9962 6.6009 3.5942 0.4520 0.2533 0.1568 1.6991 0.0258 1.1783 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 47: 93.4422 -5.8442 -0.1286 2.2578 -0.9819 6.2709 3.4145 0.4492 0.2637 0.1694 1.6754 0.0317 1.3442 0.0599</span> +<span class="r-out co"><span class="r-pr">#></span> 48: 93.0996 -5.5881 -0.1307 2.2541 -0.9882 5.9573 3.2438 0.4480 0.2665 0.1695 1.7040 0.0285 1.6825 0.0426</span> +<span class="r-out co"><span class="r-pr">#></span> 49: 93.3649 -5.8011 -0.1260 2.2595 -0.9704 5.7230 3.0816 0.4399 0.2646 0.1715 1.6544 0.0297 1.6414 0.0418</span> +<span class="r-out co"><span class="r-pr">#></span> 50: 93.9331 -5.8731 -0.1195 2.2615 -0.9837 5.4368 2.9275 0.4453 0.2735 0.1940 1.6316 0.0289 1.6885 0.0392</span> +<span class="r-out co"><span class="r-pr">#></span> 51: 93.6092 -5.8721 -0.1237 2.2599 -1.0015 5.1650 2.7811 0.4413 0.2865 0.1939 1.6492 0.0272 1.7686 0.0358</span> +<span class="r-out co"><span class="r-pr">#></span> 52: 93.3008 -5.9775 -0.1277 2.2628 -0.9962 4.9067 3.1139 0.4438 0.2946 0.1963 1.5642 0.0337 1.7391 0.0335</span> +<span class="r-out co"><span class="r-pr">#></span> 53: 93.6347 -6.0805 -0.1189 2.2663 -1.0177 4.6614 3.5169 0.4335 0.2962 0.2043 1.5275 0.0343 1.7417 0.0366</span> +<span class="r-out co"><span class="r-pr">#></span> 54: 93.5781 -6.0412 -0.1166 2.2573 -1.0015 4.4283 3.3411 0.4395 0.2912 0.2080 1.5464 0.0346 1.7584 0.0359</span> +<span class="r-out co"><span class="r-pr">#></span> 55: 93.9675 -6.0867 -0.0952 2.2970 -0.9987 4.2069 3.6762 0.4550 0.2780 0.1988 1.5138 0.0405 1.6251 0.0472</span> +<span class="r-out co"><span class="r-pr">#></span> 56: 94.4069 -6.1375 -0.0943 2.2975 -1.0190 3.9966 4.2280 0.4550 0.2806 0.1945 1.5294 0.0425 1.6443 0.0468</span> +<span class="r-out co"><span class="r-pr">#></span> 57: 93.8076 -6.1618 -0.0936 2.2687 -1.0237 3.7967 4.3085 0.4524 0.2666 0.1897 1.5227 0.0414 1.6955 0.0438</span> +<span class="r-out co"><span class="r-pr">#></span> 58: 93.9188 -6.2272 -0.0947 2.2767 -1.0408 3.6069 4.6707 0.4536 0.2676 0.1873 1.5201 0.0425 1.5336 0.0550</span> +<span class="r-out co"><span class="r-pr">#></span> 59: 93.9572 -6.3460 -0.1074 2.2746 -1.0069 3.4266 5.8058 0.4614 0.2718 0.1919 1.5533 0.0417 1.6227 0.0460</span> +<span class="r-out co"><span class="r-pr">#></span> 60: 93.5430 -6.1622 -0.1048 2.2861 -0.9959 3.2552 5.5155 0.4535 0.2848 0.1823 1.4745 0.0431 1.5242 0.0522</span> +<span class="r-out co"><span class="r-pr">#></span> 61: 93.8016 -6.4079 -0.1065 2.2897 -1.0325 3.0925 5.9252 0.4583 0.2901 0.1732 1.5364 0.0365 1.4623 0.0550</span> +<span class="r-out co"><span class="r-pr">#></span> 62: 93.4249 -6.2284 -0.0967 2.3126 -1.0208 2.9378 5.6289 0.4429 0.2756 0.1645 1.6111 0.0325 1.3996 0.0618</span> +<span class="r-out co"><span class="r-pr">#></span> 63: 93.2335 -6.0996 -0.1051 2.3047 -0.9976 2.7909 5.3475 0.4292 0.2719 0.1633 1.6010 0.0326 1.5115 0.0494</span> +<span class="r-out co"><span class="r-pr">#></span> 64: 92.7091 -6.1109 -0.1041 2.3032 -0.9746 3.2610 5.0801 0.4301 0.2793 0.1751 1.5979 0.0302 1.3867 0.0575</span> +<span class="r-out co"><span class="r-pr">#></span> 65: 92.6059 -6.0049 -0.1077 2.3062 -0.9853 3.0979 4.8261 0.4316 0.2826 0.1714 1.6357 0.0272 1.3931 0.0543</span> +<span class="r-out co"><span class="r-pr">#></span> 66: 92.7778 -6.0856 -0.1040 2.3057 -0.9828 2.9430 4.5848 0.4362 0.2888 0.1628 1.6126 0.0316 1.4340 0.0505</span> +<span class="r-out co"><span class="r-pr">#></span> 67: 93.0325 -6.1775 -0.1085 2.3122 -0.9714 2.7959 4.3790 0.4464 0.2843 0.1547 1.6090 0.0354 1.4966 0.0448</span> +<span class="r-out co"><span class="r-pr">#></span> 68: 92.8987 -5.8741 -0.1089 2.3184 -0.9567 2.6561 4.1601 0.4389 0.2866 0.1470 1.5888 0.0347 1.4492 0.0507</span> +<span class="r-out co"><span class="r-pr">#></span> 69: 92.7300 -6.0473 -0.1070 2.3082 -0.9739 2.5233 4.0183 0.4371 0.3158 0.1527 1.5904 0.0298 1.5387 0.0477</span> +<span class="r-out co"><span class="r-pr">#></span> 70: 92.5285 -6.0962 -0.1115 2.3179 -0.9785 2.4856 4.0612 0.4380 0.3059 0.1504 1.5237 0.0402 1.4541 0.0463</span> +<span class="r-out co"><span class="r-pr">#></span> 71: 92.3975 -6.2090 -0.1269 2.2819 -0.9713 2.3613 4.3811 0.4173 0.2906 0.1520 1.5388 0.0316 1.3713 0.0584</span> +<span class="r-out co"><span class="r-pr">#></span> 72: 92.1593 -6.2214 -0.1217 2.2950 -0.9481 2.2433 5.1205 0.4227 0.2760 0.1605 1.5431 0.0312 1.5797 0.0459</span> +<span class="r-out co"><span class="r-pr">#></span> 73: 92.1195 -6.6667 -0.1244 2.3076 -0.9642 2.1311 7.6538 0.4124 0.2622 0.1525 1.4505 0.0375 1.2810 0.0595</span> +<span class="r-out co"><span class="r-pr">#></span> 74: 92.2191 -6.6665 -0.1278 2.2989 -0.9703 2.0246 7.2711 0.4098 0.2491 0.1666 1.4309 0.0384 1.2717 0.0638</span> +<span class="r-out co"><span class="r-pr">#></span> 75: 92.4656 -6.8881 -0.1274 2.3011 -0.9595 1.9233 8.3835 0.4147 0.2367 0.1656 1.4181 0.0424 1.2498 0.0620</span> +<span class="r-out co"><span class="r-pr">#></span> 76: 92.4593 -6.2323 -0.1203 2.2912 -0.9799 1.8272 7.9643 0.3967 0.2301 0.1596 1.5448 0.0336 1.6758 0.0359</span> +<span class="r-out co"><span class="r-pr">#></span> 77: 92.4501 -6.1123 -0.1219 2.2889 -0.9426 1.7358 7.5661 0.4049 0.2299 0.1594 1.5380 0.0327 1.6947 0.0364</span> +<span class="r-out co"><span class="r-pr">#></span> 78: 92.5059 -6.0339 -0.1198 2.2985 -0.9544 1.6490 7.1878 0.4007 0.2422 0.1568 1.5722 0.0302 1.5665 0.0415</span> +<span class="r-out co"><span class="r-pr">#></span> 79: 92.4302 -6.6428 -0.1141 2.3119 -0.9421 1.5666 9.0889 0.3986 0.2340 0.1489 1.5029 0.0306 1.1894 0.0638</span> +<span class="r-out co"><span class="r-pr">#></span> 80: 92.5305 -6.3036 -0.1127 2.3099 -0.9406 1.9062 8.6344 0.4091 0.2327 0.1648 1.5558 0.0308 1.0136 0.0749</span> +<span class="r-out co"><span class="r-pr">#></span> 81: 92.6652 -6.0832 -0.1167 2.2994 -0.9552 2.3641 8.2027 0.4142 0.2348 0.1566 1.6232 0.0300 1.1320 0.0712</span> +<span class="r-out co"><span class="r-pr">#></span> 82: 92.5109 -6.1524 -0.1100 2.3037 -0.9686 2.2459 7.7926 0.4145 0.2381 0.1695 1.6128 0.0306 1.6145 0.0413</span> +<span class="r-out co"><span class="r-pr">#></span> 83: 92.6455 -6.3979 -0.1059 2.3245 -0.9573 2.1336 8.1077 0.4060 0.2348 0.1667 1.6039 0.0304 1.6251 0.0419</span> +<span class="r-out co"><span class="r-pr">#></span> 84: 92.5768 -6.3469 -0.0979 2.3177 -0.9346 2.0269 8.2125 0.4141 0.2439 0.1720 1.6334 0.0302 1.5803 0.0450</span> +<span class="r-out co"><span class="r-pr">#></span> 85: 92.7920 -6.3536 -0.0969 2.3363 -0.9389 1.9256 8.1820 0.4035 0.2512 0.1713 1.5815 0.0338 1.1193 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 86: 92.8571 -6.2567 -0.0911 2.3426 -0.9633 1.8293 8.1211 0.4008 0.2659 0.1627 1.5840 0.0356 1.2425 0.0639</span> +<span class="r-out co"><span class="r-pr">#></span> 87: 92.9101 -6.1557 -0.0937 2.3326 -0.9624 1.7378 7.7151 0.3950 0.2839 0.1546 1.6017 0.0354 1.0600 0.0766</span> +<span class="r-out co"><span class="r-pr">#></span> 88: 92.7649 -6.2151 -0.0881 2.3275 -0.9967 1.6509 7.3293 0.4046 0.2697 0.1469 1.6092 0.0302 1.1839 0.0693</span> +<span class="r-out co"><span class="r-pr">#></span> 89: 92.9350 -5.9222 -0.0903 2.3372 -0.9612 1.5684 6.9628 0.4058 0.2818 0.1395 1.5957 0.0335 1.5450 0.0444</span> +<span class="r-out co"><span class="r-pr">#></span> 90: 92.7895 -5.9348 -0.0890 2.3457 -0.9601 1.4900 6.6147 0.4070 0.2705 0.1430 1.5716 0.0378 1.4918 0.0439</span> +<span class="r-out co"><span class="r-pr">#></span> 91: 93.0113 -5.9302 -0.0997 2.3316 -0.9489 1.4155 6.2840 0.4424 0.2929 0.1410 1.5582 0.0377 1.2459 0.0582</span> +<span class="r-out co"><span class="r-pr">#></span> 92: 92.8603 -6.3366 -0.0918 2.3356 -0.9938 1.3447 5.9698 0.4287 0.2929 0.1531 1.4906 0.0398 1.2421 0.0605</span> +<span class="r-out co"><span class="r-pr">#></span> 93: 92.8094 -6.1097 -0.0953 2.3382 -0.9996 1.2775 5.6713 0.4309 0.2783 0.1597 1.4317 0.0468 1.2694 0.0584</span> +<span class="r-out co"><span class="r-pr">#></span> 94: 92.7100 -6.1043 -0.0909 2.3287 -0.9928 1.3828 5.3877 0.4337 0.2698 0.1517 1.4173 0.0489 1.4335 0.0476</span> +<span class="r-out co"><span class="r-pr">#></span> 95: 92.2055 -6.1792 -0.0889 2.3553 -0.9983 1.3137 5.1183 0.4209 0.3273 0.1566 1.4865 0.0417 1.2485 0.0681</span> +<span class="r-out co"><span class="r-pr">#></span> 96: 92.3225 -6.2710 -0.0811 2.3734 -1.0043 1.3428 4.8624 0.4121 0.3110 0.1532 1.5817 0.0374 1.5209 0.0532</span> +<span class="r-out co"><span class="r-pr">#></span> 97: 92.2983 -6.3023 -0.0776 2.3615 -0.9801 1.2757 4.6193 0.4221 0.3018 0.1455 1.5971 0.0337 1.2137 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 98: 92.1433 -6.3114 -0.0935 2.3269 -0.9866 1.2227 4.8121 0.4327 0.2907 0.1694 1.5524 0.0303 1.1779 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 99: 92.1631 -6.3090 -0.0908 2.3197 -0.9891 1.1615 4.9271 0.4169 0.2859 0.1736 1.5303 0.0334 1.6227 0.0511</span> +<span class="r-out co"><span class="r-pr">#></span> 100: 92.1185 -6.3603 -0.0950 2.3280 -1.0209 1.1035 5.0957 0.4213 0.2924 0.1817 1.5991 0.0330 1.7197 0.0445</span> +<span class="r-out co"><span class="r-pr">#></span> 101: 92.3964 -6.0447 -0.0898 2.3347 -1.0164 1.0483 4.8409 0.4251 0.2778 0.1727 1.5708 0.0422 1.6197 0.0461</span> +<span class="r-out co"><span class="r-pr">#></span> 102: 92.6597 -6.2545 -0.0954 2.3264 -1.0206 0.9959 4.5989 0.4218 0.2736 0.1640 1.5853 0.0408 1.5912 0.0455</span> +<span class="r-out co"><span class="r-pr">#></span> 103: 92.7866 -6.3292 -0.0933 2.3148 -1.0013 0.9461 4.8935 0.4234 0.2599 0.1688 1.6299 0.0399 1.5921 0.0445</span> +<span class="r-out co"><span class="r-pr">#></span> 104: 92.8098 -6.2608 -0.1009 2.3014 -0.9947 0.8988 4.7750 0.4306 0.2548 0.1813 1.6363 0.0378 1.6713 0.0427</span> +<span class="r-out co"><span class="r-pr">#></span> 105: 92.8300 -5.9827 -0.1028 2.3155 -0.9896 0.8538 4.5362 0.4339 0.2664 0.1722 1.6079 0.0397 1.3691 0.0573</span> +<span class="r-out co"><span class="r-pr">#></span> 106: 92.8218 -6.1138 -0.1024 2.3462 -0.9750 0.8299 4.3094 0.4494 0.2530 0.1636 1.5761 0.0389 1.2857 0.0595</span> +<span class="r-out co"><span class="r-pr">#></span> 107: 92.9304 -6.0063 -0.1002 2.3269 -0.9778 0.7884 4.0939 0.4600 0.2404 0.1620 1.6499 0.0373 1.2101 0.0675</span> +<span class="r-out co"><span class="r-pr">#></span> 108: 92.9072 -6.0928 -0.0991 2.3183 -0.9732 0.7489 4.4394 0.4584 0.2518 0.1539 1.6509 0.0332 1.2346 0.0670</span> +<span class="r-out co"><span class="r-pr">#></span> 109: 92.7504 -6.1545 -0.0862 2.3423 -0.9618 0.7115 4.7501 0.4371 0.2766 0.1465 1.5755 0.0349 1.1552 0.0701</span> +<span class="r-out co"><span class="r-pr">#></span> 110: 92.9277 -6.3786 -0.0904 2.3468 -0.9402 0.6759 5.8620 0.4328 0.2821 0.1703 1.4661 0.0439 1.3292 0.0609</span> +<span class="r-out co"><span class="r-pr">#></span> 111: 92.8023 -5.8686 -0.0886 2.3653 -0.9417 0.7635 5.5689 0.4288 0.2680 0.1618 1.4278 0.0502 1.4715 0.0468</span> +<span class="r-out co"><span class="r-pr">#></span> 112: 92.9411 -5.8095 -0.0883 2.3625 -0.9322 0.8592 5.2905 0.4562 0.2586 0.1537 1.3920 0.0513 1.1766 0.0648</span> +<span class="r-out co"><span class="r-pr">#></span> 113: 92.9845 -6.0499 -0.0761 2.3626 -0.9533 0.8163 5.0259 0.4403 0.2595 0.1532 1.4306 0.0450 1.1416 0.0645</span> +<span class="r-out co"><span class="r-pr">#></span> 114: 92.7735 -6.0605 -0.0694 2.3497 -0.9646 0.7754 4.7746 0.4394 0.2682 0.1576 1.4866 0.0344 1.1127 0.0745</span> +<span class="r-out co"><span class="r-pr">#></span> 115: 92.7048 -6.1327 -0.0702 2.3427 -0.9910 0.7367 4.5359 0.4257 0.2736 0.1497 1.5045 0.0413 1.2783 0.0677</span> +<span class="r-out co"><span class="r-pr">#></span> 116: 92.7131 -6.0115 -0.0751 2.3370 -0.9899 0.6998 4.3091 0.4187 0.2638 0.1422 1.6036 0.0325 1.1109 0.0748</span> +<span class="r-out co"><span class="r-pr">#></span> 117: 92.7720 -5.9163 -0.0709 2.3503 -0.9566 0.6648 4.0937 0.4185 0.2555 0.1417 1.6016 0.0297 1.0778 0.0774</span> +<span class="r-out co"><span class="r-pr">#></span> 118: 92.9182 -5.9312 -0.0812 2.3436 -0.9731 0.6316 3.8890 0.4084 0.2667 0.1400 1.5698 0.0320 1.2364 0.0665</span> +<span class="r-out co"><span class="r-pr">#></span> 119: 92.9546 -5.9622 -0.0870 2.3330 -0.9934 0.6000 3.6945 0.4035 0.2867 0.1486 1.5364 0.0343 1.5892 0.0489</span> +<span class="r-out co"><span class="r-pr">#></span> 120: 92.9168 -6.0966 -0.0905 2.3301 -1.0045 0.5700 3.6677 0.3988 0.2871 0.1567 1.5378 0.0349 1.0886 0.0796</span> +<span class="r-out co"><span class="r-pr">#></span> 121: 92.7767 -6.1038 -0.0802 2.3396 -0.9815 0.5981 4.3032 0.3803 0.2884 0.1684 1.4788 0.0335 1.0886 0.0796</span> +<span class="r-out co"><span class="r-pr">#></span> 122: 92.8439 -6.2425 -0.0799 2.3323 -0.9987 0.6537 4.5745 0.3884 0.2834 0.1600 1.4786 0.0346 1.2146 0.0682</span> +<span class="r-out co"><span class="r-pr">#></span> 123: 92.8219 -5.7869 -0.0872 2.3478 -0.9619 0.7886 4.3458 0.3951 0.2887 0.1658 1.4827 0.0341 1.3911 0.0559</span> +<span class="r-out co"><span class="r-pr">#></span> 124: 92.7930 -5.7551 -0.0819 2.3559 -0.9809 0.8922 4.1285 0.3907 0.2972 0.1575 1.5329 0.0330 1.3824 0.0594</span> +<span class="r-out co"><span class="r-pr">#></span> 125: 92.7488 -5.9406 -0.0819 2.3550 -0.9797 0.8476 3.9221 0.3907 0.2996 0.1733 1.5096 0.0333 1.3148 0.0667</span> +<span class="r-out co"><span class="r-pr">#></span> 126: 92.7926 -5.7106 -0.0824 2.3560 -0.9653 0.8052 3.7260 0.3918 0.3018 0.1854 1.4237 0.0381 1.2607 0.0639</span> +<span class="r-out co"><span class="r-pr">#></span> 127: 92.9153 -5.6682 -0.0717 2.3654 -0.9645 0.7649 3.5397 0.3722 0.2948 0.1784 1.4679 0.0415 1.2310 0.0695</span> +<span class="r-out co"><span class="r-pr">#></span> 128: 92.8827 -5.7984 -0.0783 2.3813 -1.0047 1.1012 3.3627 0.3802 0.2997 0.1694 1.5187 0.0442 1.2884 0.0649</span> +<span class="r-out co"><span class="r-pr">#></span> 129: 92.8727 -5.7191 -0.0785 2.3426 -0.9857 1.0461 3.1946 0.3784 0.2984 0.1610 1.4757 0.0398 1.1695 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 130: 92.8689 -5.8036 -0.0935 2.3123 -0.9783 0.9938 3.0348 0.4184 0.2980 0.1723 1.5143 0.0319 1.2298 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 131: 92.8733 -5.6707 -0.0988 2.3045 -0.9936 1.3313 2.8831 0.4277 0.2831 0.1816 1.5919 0.0329 1.5260 0.0533</span> +<span class="r-out co"><span class="r-pr">#></span> 132: 92.5761 -5.7773 -0.0925 2.3211 -0.9661 1.2647 2.7389 0.4216 0.2815 0.1995 1.5306 0.0321 1.5863 0.0520</span> +<span class="r-out co"><span class="r-pr">#></span> 133: 92.4512 -5.7800 -0.0920 2.3269 -0.9625 1.2015 2.6020 0.4242 0.2674 0.1955 1.5669 0.0288 1.4087 0.0606</span> +<span class="r-out co"><span class="r-pr">#></span> 134: 92.5625 -5.7968 -0.0965 2.3271 -0.9728 1.1414 2.4719 0.4201 0.2753 0.1945 1.5935 0.0311 1.5348 0.0534</span> +<span class="r-out co"><span class="r-pr">#></span> 135: 92.3448 -5.6624 -0.0961 2.3303 -0.9600 1.0843 2.3483 0.4193 0.2728 0.1983 1.6245 0.0305 1.6281 0.0506</span> +<span class="r-out co"><span class="r-pr">#></span> 136: 92.3407 -5.7523 -0.0932 2.3208 -0.9897 1.0301 2.3267 0.4107 0.2668 0.1884 1.5933 0.0358 1.2970 0.0657</span> +<span class="r-out co"><span class="r-pr">#></span> 137: 92.3940 -6.0148 -0.1046 2.2981 -0.9866 0.9786 3.1382 0.4166 0.3012 0.1790 1.5077 0.0385 1.1944 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 138: 92.3556 -5.9912 -0.1039 2.2969 -0.9920 0.9297 3.2144 0.4208 0.3039 0.1703 1.5042 0.0378 1.2588 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 139: 92.5548 -5.9253 -0.1177 2.2723 -1.0079 0.8832 3.2648 0.4049 0.3263 0.1618 1.5558 0.0382 1.2673 0.0698</span> +<span class="r-out co"><span class="r-pr">#></span> 140: 92.6546 -6.0596 -0.1368 2.2659 -0.9922 0.8390 3.3893 0.3846 0.3100 0.1537 1.5475 0.0355 1.3190 0.0629</span> +<span class="r-out co"><span class="r-pr">#></span> 141: 92.6661 -5.9744 -0.1379 2.2793 -0.9754 0.8287 3.2725 0.3800 0.3178 0.1528 1.5076 0.0361 1.4087 0.0540</span> +<span class="r-out co"><span class="r-pr">#></span> 142: 92.5681 -5.7650 -0.1033 2.3249 -0.9613 0.7872 3.1089 0.3610 0.3564 0.1701 1.4733 0.0332 1.2603 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 143: 92.4184 -5.6070 -0.1033 2.3520 -0.9764 0.7479 2.9534 0.3591 0.3758 0.1674 1.5420 0.0390 1.3280 0.0614</span> +<span class="r-out co"><span class="r-pr">#></span> 144: 92.5354 -5.6144 -0.0978 2.3801 -0.9425 0.7105 2.8058 0.3538 0.3606 0.1722 1.4884 0.0400 1.3455 0.0620</span> +<span class="r-out co"><span class="r-pr">#></span> 145: 92.4207 -5.6541 -0.0746 2.3873 -0.9633 0.6750 2.6655 0.3361 0.3426 0.1718 1.4981 0.0416 1.2440 0.0685</span> +<span class="r-out co"><span class="r-pr">#></span> 146: 92.3058 -5.6608 -0.0731 2.3755 -0.9732 0.6412 2.5322 0.3193 0.3304 0.1719 1.6391 0.0348 1.1788 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 147: 92.4067 -5.7615 -0.0746 2.3775 -0.9903 0.6091 2.4056 0.3148 0.3311 0.1709 1.6695 0.0314 1.2931 0.0676</span> +<span class="r-out co"><span class="r-pr">#></span> 148: 92.3739 -5.8812 -0.0820 2.3644 -0.9823 0.5787 2.7260 0.3332 0.3296 0.1794 1.6168 0.0303 1.3206 0.0670</span> +<span class="r-out co"><span class="r-pr">#></span> 149: 92.4456 -5.8277 -0.0921 2.3508 -0.9924 0.5498 2.8750 0.3368 0.3305 0.1917 1.5602 0.0302 1.3622 0.0608</span> +<span class="r-out co"><span class="r-pr">#></span> 150: 92.5049 -5.7964 -0.1003 2.3353 -0.9809 0.5223 2.7312 0.3291 0.3634 0.1874 1.5035 0.0301 1.4002 0.0615</span> +<span class="r-out co"><span class="r-pr">#></span> 151: 92.3292 -6.0377 -0.1039 2.3301 -0.9866 0.4962 3.3342 0.3348 0.3626 0.1780 1.4819 0.0298 1.3217 0.0672</span> +<span class="r-out co"><span class="r-pr">#></span> 152: 92.3747 -6.0460 -0.1023 2.3154 -1.0242 0.5079 3.4530 0.3371 0.3518 0.1674 1.6034 0.0296 1.2304 0.0749</span> +<span class="r-out co"><span class="r-pr">#></span> 153: 92.3909 -5.8707 -0.1008 2.3284 -0.9897 0.5623 2.8180 0.3480 0.3792 0.1749 1.4953 0.0291 1.3442 0.0677</span> +<span class="r-out co"><span class="r-pr">#></span> 154: 92.2532 -5.9313 -0.0991 2.3232 -0.9839 0.5340 3.3946 0.3502 0.3723 0.1729 1.4837 0.0280 1.1452 0.0776</span> +<span class="r-out co"><span class="r-pr">#></span> 155: 92.1782 -6.1012 -0.0988 2.3339 -0.9600 0.3900 3.9676 0.3593 0.3704 0.1531 1.4927 0.0286 1.1848 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 156: 92.2225 -5.8387 -0.0991 2.3393 -0.9459 0.3294 3.0685 0.3598 0.3808 0.1568 1.5540 0.0318 1.3419 0.0671</span> +<span class="r-out co"><span class="r-pr">#></span> 157: 92.2411 -5.7045 -0.1038 2.3578 -0.9252 0.2797 2.5238 0.3716 0.3579 0.1653 1.4704 0.0373 1.1959 0.0686</span> +<span class="r-out co"><span class="r-pr">#></span> 158: 92.2865 -5.6692 -0.1009 2.3771 -0.9532 0.2840 2.4144 0.3592 0.3610 0.1641 1.5065 0.0389 1.1780 0.0674</span> +<span class="r-out co"><span class="r-pr">#></span> 159: 92.2771 -5.7526 -0.0782 2.3632 -0.9771 0.2996 2.7295 0.3357 0.3779 0.1606 1.5818 0.0366 1.1512 0.0781</span> +<span class="r-out co"><span class="r-pr">#></span> 160: 92.3400 -5.8039 -0.0811 2.3615 -0.9453 0.2707 2.7305 0.3373 0.3834 0.1528 1.4765 0.0370 1.1427 0.0756</span> +<span class="r-out co"><span class="r-pr">#></span> 161: 92.4180 -5.7448 -0.0961 2.3653 -0.9508 0.2965 2.6051 0.3666 0.3833 0.1647 1.4581 0.0364 0.9817 0.0827</span> +<span class="r-out co"><span class="r-pr">#></span> 162: 92.4487 -5.8952 -0.0889 2.3460 -0.9646 0.2370 3.1413 0.3460 0.3801 0.1571 1.4528 0.0346 1.0006 0.0798</span> +<span class="r-out co"><span class="r-pr">#></span> 163: 92.5251 -5.8567 -0.0987 2.3342 -0.9615 0.1453 2.9917 0.3535 0.3735 0.1452 1.4521 0.0330 1.0498 0.0766</span> +<span class="r-out co"><span class="r-pr">#></span> 164: 92.5949 -6.1580 -0.1008 2.3332 -0.9749 0.1095 4.1797 0.3586 0.3767 0.1355 1.4659 0.0310 1.0218 0.0797</span> +<span class="r-out co"><span class="r-pr">#></span> 165: 92.5794 -6.0542 -0.1001 2.3321 -0.9795 0.1332 4.2924 0.3588 0.3752 0.1386 1.4858 0.0313 0.9836 0.0812</span> +<span class="r-out co"><span class="r-pr">#></span> 166: 92.6686 -6.0065 -0.0960 2.3623 -0.9532 0.1465 4.0810 0.3439 0.3683 0.1647 1.3929 0.0372 0.9354 0.0837</span> +<span class="r-out co"><span class="r-pr">#></span> 167: 92.7086 -6.2096 -0.0895 2.3656 -0.9552 0.1938 4.6857 0.3325 0.3519 0.1681 1.4281 0.0362 1.0329 0.0784</span> +<span class="r-out co"><span class="r-pr">#></span> 168: 92.6096 -6.0709 -0.0880 2.3595 -0.9474 0.2141 4.1277 0.3379 0.3527 0.1620 1.4264 0.0347 0.9627 0.0836</span> +<span class="r-out co"><span class="r-pr">#></span> 169: 92.5365 -5.9418 -0.0919 2.3546 -0.9575 0.3620 3.7767 0.3489 0.3589 0.1609 1.4761 0.0360 1.1348 0.0745</span> +<span class="r-out co"><span class="r-pr">#></span> 170: 92.6270 -5.8404 -0.0935 2.3562 -0.9517 0.3312 3.2506 0.3552 0.3607 0.1560 1.4506 0.0383 1.0731 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 171: 92.5606 -5.9213 -0.0899 2.3513 -0.9554 0.4399 3.5587 0.3599 0.3646 0.1385 1.4779 0.0349 0.9844 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 172: 92.3630 -5.7066 -0.0765 2.3798 -0.9314 0.5208 2.5578 0.3458 0.3657 0.1547 1.4900 0.0348 1.0485 0.0765</span> +<span class="r-out co"><span class="r-pr">#></span> 173: 92.2527 -5.5811 -0.0713 2.4173 -0.9221 0.8674 2.2100 0.3448 0.3370 0.1513 1.5403 0.0445 1.4403 0.0518</span> +<span class="r-out co"><span class="r-pr">#></span> 174: 92.3852 -5.5348 -0.0712 2.4066 -0.9033 0.7543 2.1568 0.3457 0.3324 0.1482 1.5322 0.0407 1.2744 0.0623</span> +<span class="r-out co"><span class="r-pr">#></span> 175: 92.4798 -5.5494 -0.0712 2.4004 -0.9100 0.5675 2.0147 0.3457 0.3333 0.1629 1.5229 0.0383 1.2917 0.0655</span> +<span class="r-out co"><span class="r-pr">#></span> 176: 92.5881 -5.5613 -0.0675 2.4180 -0.9188 0.4011 2.0736 0.3413 0.3487 0.1781 1.5149 0.0389 1.1499 0.0669</span> +<span class="r-out co"><span class="r-pr">#></span> 177: 92.6015 -5.4951 -0.0494 2.4324 -0.9525 0.4992 1.9009 0.3629 0.3353 0.1919 1.4881 0.0393 1.2289 0.0650</span> +<span class="r-out co"><span class="r-pr">#></span> 178: 92.6317 -5.4943 -0.0505 2.4373 -0.9298 0.5087 1.6116 0.3631 0.3324 0.1906 1.4475 0.0454 1.0764 0.0701</span> +<span class="r-out co"><span class="r-pr">#></span> 179: 92.7043 -5.5326 -0.0419 2.4386 -0.9376 0.4350 1.8241 0.3577 0.3757 0.1991 1.4445 0.0424 0.9626 0.0833</span> +<span class="r-out co"><span class="r-pr">#></span> 180: 92.7457 -5.5591 -0.0371 2.4684 -0.9450 0.3973 1.7797 0.3507 0.3707 0.1944 1.4392 0.0415 1.0784 0.0764</span> +<span class="r-out co"><span class="r-pr">#></span> 181: 92.6287 -5.5741 -0.0368 2.4489 -0.9459 0.4744 1.8016 0.3502 0.3544 0.1970 1.4317 0.0392 0.9225 0.0848</span> +<span class="r-out co"><span class="r-pr">#></span> 182: 92.6121 -5.5593 -0.0316 2.4610 -0.9345 0.6054 1.9206 0.3492 0.3538 0.1855 1.4410 0.0367 0.8977 0.0878</span> +<span class="r-out co"><span class="r-pr">#></span> 183: 92.4258 -5.4737 -0.0393 2.4592 -0.9319 0.8062 1.7845 0.3528 0.3544 0.1649 1.4545 0.0409 1.0723 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 184: 92.3939 -5.5961 -0.0479 2.4268 -0.9435 1.0246 2.2534 0.3497 0.3289 0.1363 1.5022 0.0370 1.1058 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 185: 92.4673 -5.5415 -0.0525 2.4157 -0.9058 0.8296 2.2848 0.3406 0.3314 0.1706 1.4935 0.0367 1.1362 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 186: 92.4122 -5.6594 -0.0574 2.4466 -0.9430 0.9133 2.3350 0.3327 0.3596 0.1506 1.4450 0.0404 1.2273 0.0629</span> +<span class="r-out co"><span class="r-pr">#></span> 187: 92.5416 -5.5472 -0.0521 2.4393 -0.9261 0.9731 1.9228 0.3208 0.3673 0.1421 1.4890 0.0409 1.2553 0.0626</span> +<span class="r-out co"><span class="r-pr">#></span> 188: 92.5502 -5.6425 -0.0591 2.4345 -0.9246 0.9315 2.2041 0.3184 0.3639 0.1319 1.4896 0.0392 1.0986 0.0684</span> +<span class="r-out co"><span class="r-pr">#></span> 189: 92.4180 -5.6737 -0.0504 2.4448 -0.9191 0.9006 2.4647 0.3102 0.3743 0.1648 1.4649 0.0397 1.1320 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 190: 92.5821 -5.5823 -0.0363 2.4588 -0.9205 0.9862 2.2692 0.2820 0.4087 0.1459 1.3938 0.0412 0.9562 0.0815</span> +<span class="r-out co"><span class="r-pr">#></span> 191: 92.3708 -5.5825 -0.0418 2.4621 -0.9231 0.9867 2.4743 0.2890 0.4196 0.1445 1.4619 0.0403 0.9630 0.0811</span> +<span class="r-out co"><span class="r-pr">#></span> 192: 92.2628 -5.5337 -0.0366 2.4392 -0.9194 0.6944 2.2771 0.2909 0.4169 0.1279 1.4745 0.0363 0.8601 0.0892</span> +<span class="r-out co"><span class="r-pr">#></span> 193: 92.4854 -5.6303 -0.0352 2.4484 -0.9316 0.4403 2.3253 0.2928 0.4109 0.1282 1.4768 0.0399 0.8886 0.0871</span> +<span class="r-out co"><span class="r-pr">#></span> 194: 92.4900 -5.5824 -0.0372 2.4648 -0.9451 0.4891 2.6428 0.2899 0.4160 0.1331 1.5124 0.0412 0.9340 0.0853</span> +<span class="r-out co"><span class="r-pr">#></span> 195: 92.4685 -5.7658 -0.0357 2.4659 -0.9217 0.4549 3.3767 0.2921 0.4171 0.1552 1.5062 0.0396 1.0336 0.0817</span> +<span class="r-out co"><span class="r-pr">#></span> 196: 92.4125 -5.7544 -0.0255 2.4834 -0.9230 0.4146 3.1963 0.3000 0.4369 0.1501 1.4560 0.0430 0.9942 0.0813</span> +<span class="r-out co"><span class="r-pr">#></span> 197: 92.3284 -5.9347 -0.0305 2.4860 -0.9448 0.4115 3.5642 0.3129 0.4314 0.1740 1.3441 0.0473 1.0954 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 198: 92.3428 -5.9255 -0.0266 2.4822 -0.9463 0.3258 3.4818 0.3185 0.4163 0.1716 1.3868 0.0447 0.9452 0.0788</span> +<span class="r-out co"><span class="r-pr">#></span> 199: 92.1692 -6.0683 -0.0227 2.4860 -0.9495 0.2685 4.4044 0.3149 0.4064 0.1824 1.3558 0.0478 1.0294 0.0749</span> +<span class="r-out co"><span class="r-pr">#></span> 200: 92.0965 -6.1541 -0.0261 2.4793 -0.9288 0.2210 4.4026 0.3265 0.4200 0.1772 1.3348 0.0441 1.0018 0.0761</span> +<span class="r-out co"><span class="r-pr">#></span> 201: 92.1362 -6.1170 -0.0244 2.4776 -0.9237 0.1801 4.4160 0.3276 0.4303 0.1732 1.3479 0.0418 0.9419 0.0809</span> +<span class="r-out co"><span class="r-pr">#></span> 202: 92.1114 -6.0898 -0.0233 2.4862 -0.9253 0.1506 4.4494 0.3286 0.4305 0.1656 1.3473 0.0440 0.9394 0.0802</span> +<span class="r-out co"><span class="r-pr">#></span> 203: 92.0893 -6.1307 -0.0233 2.4894 -0.9258 0.1510 4.7958 0.3310 0.4233 0.1673 1.3396 0.0457 0.9617 0.0788</span> +<span class="r-out co"><span class="r-pr">#></span> 204: 92.0870 -6.0914 -0.0230 2.4867 -0.9234 0.1589 4.6265 0.3316 0.4237 0.1643 1.3478 0.0456 0.9509 0.0793</span> +<span class="r-out co"><span class="r-pr">#></span> 205: 92.0800 -6.0960 -0.0228 2.4867 -0.9256 0.1613 4.6319 0.3321 0.4226 0.1623 1.3399 0.0463 0.9547 0.0789</span> +<span class="r-out co"><span class="r-pr">#></span> 206: 92.1037 -6.0869 -0.0238 2.4833 -0.9264 0.1648 4.5547 0.3341 0.4186 0.1606 1.3351 0.0466 0.9453 0.0797</span> +<span class="r-out co"><span class="r-pr">#></span> 207: 92.1212 -6.0561 -0.0247 2.4821 -0.9299 0.1677 4.3736 0.3363 0.4150 0.1602 1.3394 0.0467 0.9552 0.0790</span> +<span class="r-out co"><span class="r-pr">#></span> 208: 92.1203 -6.0351 -0.0260 2.4804 -0.9309 0.1616 4.2520 0.3369 0.4120 0.1613 1.3366 0.0466 0.9667 0.0785</span> +<span class="r-out co"><span class="r-pr">#></span> 209: 92.1169 -6.0133 -0.0277 2.4792 -0.9300 0.1596 4.1237 0.3352 0.4111 0.1616 1.3344 0.0464 0.9741 0.0778</span> +<span class="r-out co"><span class="r-pr">#></span> 210: 92.1195 -5.9866 -0.0289 2.4752 -0.9287 0.1586 3.9853 0.3352 0.4091 0.1602 1.3410 0.0461 0.9708 0.0778</span> +<span class="r-out co"><span class="r-pr">#></span> 211: 92.1243 -5.9458 -0.0316 2.4687 -0.9287 0.1606 3.8383 0.3366 0.4094 0.1607 1.3525 0.0455 0.9759 0.0778</span> +<span class="r-out co"><span class="r-pr">#></span> 212: 92.1384 -5.9338 -0.0345 2.4640 -0.9280 0.1635 3.7875 0.3375 0.4105 0.1594 1.3589 0.0454 0.9800 0.0776</span> +<span class="r-out co"><span class="r-pr">#></span> 213: 92.1481 -5.9191 -0.0379 2.4587 -0.9269 0.1629 3.7150 0.3375 0.4100 0.1586 1.3673 0.0449 0.9839 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 214: 92.1523 -5.9189 -0.0408 2.4542 -0.9270 0.1593 3.7061 0.3375 0.4092 0.1579 1.3731 0.0446 0.9847 0.0773</span> +<span class="r-out co"><span class="r-pr">#></span> 215: 92.1548 -5.9183 -0.0429 2.4499 -0.9269 0.1604 3.7075 0.3369 0.4095 0.1574 1.3765 0.0442 0.9821 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 216: 92.1547 -5.9171 -0.0450 2.4455 -0.9270 0.1600 3.6967 0.3368 0.4100 0.1571 1.3811 0.0438 0.9830 0.0776</span> +<span class="r-out co"><span class="r-pr">#></span> 217: 92.1556 -5.9141 -0.0468 2.4422 -0.9281 0.1580 3.6732 0.3361 0.4102 0.1578 1.3864 0.0435 0.9995 0.0770</span> +<span class="r-out co"><span class="r-pr">#></span> 218: 92.1587 -5.9173 -0.0477 2.4395 -0.9287 0.1545 3.6822 0.3351 0.4112 0.1580 1.3882 0.0432 1.0001 0.0772</span> +<span class="r-out co"><span class="r-pr">#></span> 219: 92.1590 -5.9188 -0.0483 2.4374 -0.9303 0.1540 3.6595 0.3341 0.4132 0.1578 1.3889 0.0430 0.9983 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 220: 92.1614 -5.9303 -0.0493 2.4353 -0.9321 0.1559 3.6914 0.3336 0.4141 0.1581 1.3914 0.0427 1.0003 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 221: 92.1657 -5.9455 -0.0504 2.4328 -0.9344 0.1585 3.7569 0.3329 0.4140 0.1591 1.3938 0.0424 1.0064 0.0773</span> +<span class="r-out co"><span class="r-pr">#></span> 222: 92.1697 -5.9320 -0.0515 2.4306 -0.9358 0.1617 3.6783 0.3321 0.4145 0.1600 1.3992 0.0421 1.0107 0.0772</span> +<span class="r-out co"><span class="r-pr">#></span> 223: 92.1754 -5.9205 -0.0525 2.4280 -0.9375 0.1630 3.6233 0.3313 0.4158 0.1604 1.4072 0.0416 1.0216 0.0770</span> +<span class="r-out co"><span class="r-pr">#></span> 224: 92.1809 -5.9149 -0.0534 2.4264 -0.9386 0.1623 3.5812 0.3306 0.4167 0.1607 1.4130 0.0413 1.0349 0.0764</span> +<span class="r-out co"><span class="r-pr">#></span> 225: 92.1872 -5.9099 -0.0543 2.4243 -0.9390 0.1619 3.5446 0.3299 0.4174 0.1607 1.4152 0.0411 1.0348 0.0766</span> +<span class="r-out co"><span class="r-pr">#></span> 226: 92.1935 -5.9046 -0.0554 2.4224 -0.9396 0.1631 3.5046 0.3299 0.4183 0.1608 1.4157 0.0409 1.0375 0.0766</span> +<span class="r-out co"><span class="r-pr">#></span> 227: 92.2026 -5.8964 -0.0567 2.4198 -0.9400 0.1637 3.4591 0.3303 0.4183 0.1614 1.4144 0.0408 1.0444 0.0763</span> +<span class="r-out co"><span class="r-pr">#></span> 228: 92.2069 -5.8852 -0.0578 2.4175 -0.9407 0.1633 3.4091 0.3308 0.4185 0.1621 1.4144 0.0407 1.0485 0.0763</span> +<span class="r-out co"><span class="r-pr">#></span> 229: 92.2122 -5.8844 -0.0591 2.4145 -0.9418 0.1631 3.3899 0.3314 0.4194 0.1622 1.4173 0.0404 1.0514 0.0763</span> +<span class="r-out co"><span class="r-pr">#></span> 230: 92.2183 -5.8907 -0.0604 2.4116 -0.9416 0.1640 3.4053 0.3319 0.4202 0.1616 1.4200 0.0401 1.0527 0.0764</span> +<span class="r-out co"><span class="r-pr">#></span> 231: 92.2246 -5.8895 -0.0619 2.4087 -0.9422 0.1651 3.3985 0.3323 0.4208 0.1609 1.4234 0.0400 1.0560 0.0762</span> +<span class="r-out co"><span class="r-pr">#></span> 232: 92.2282 -5.8840 -0.0632 2.4058 -0.9423 0.1641 3.3771 0.3327 0.4215 0.1609 1.4266 0.0398 1.0585 0.0762</span> +<span class="r-out co"><span class="r-pr">#></span> 233: 92.2294 -5.8775 -0.0645 2.4032 -0.9424 0.1620 3.3481 0.3335 0.4216 0.1607 1.4311 0.0395 1.0600 0.0763</span> +<span class="r-out co"><span class="r-pr">#></span> 234: 92.2311 -5.8709 -0.0658 2.4006 -0.9421 0.1626 3.3242 0.3343 0.4220 0.1602 1.4340 0.0393 1.0604 0.0764</span> +<span class="r-out co"><span class="r-pr">#></span> 235: 92.2312 -5.8656 -0.0668 2.3985 -0.9420 0.1608 3.3023 0.3350 0.4225 0.1596 1.4381 0.0391 1.0600 0.0765</span> +<span class="r-out co"><span class="r-pr">#></span> 236: 92.2289 -5.8633 -0.0675 2.3974 -0.9423 0.1599 3.2811 0.3352 0.4227 0.1589 1.4392 0.0390 1.0594 0.0765</span> +<span class="r-out co"><span class="r-pr">#></span> 237: 92.2251 -5.8641 -0.0683 2.3960 -0.9435 0.1586 3.2734 0.3351 0.4226 0.1588 1.4403 0.0389 1.0623 0.0765</span> +<span class="r-out co"><span class="r-pr">#></span> 238: 92.2242 -5.8633 -0.0690 2.3949 -0.9443 0.1579 3.2547 0.3349 0.4230 0.1590 1.4409 0.0389 1.0659 0.0765</span> +<span class="r-out co"><span class="r-pr">#></span> 239: 92.2250 -5.8612 -0.0693 2.3951 -0.9449 0.1558 3.2309 0.3346 0.4234 0.1599 1.4396 0.0389 1.0740 0.0762</span> +<span class="r-out co"><span class="r-pr">#></span> 240: 92.2264 -5.8597 -0.0696 2.3949 -0.9446 0.1550 3.2124 0.3342 0.4234 0.1603 1.4401 0.0388 1.0791 0.0760</span> +<span class="r-out co"><span class="r-pr">#></span> 241: 92.2281 -5.8562 -0.0699 2.3948 -0.9449 0.1544 3.1933 0.3339 0.4236 0.1604 1.4411 0.0388 1.0825 0.0760</span> +<span class="r-out co"><span class="r-pr">#></span> 242: 92.2289 -5.8512 -0.0703 2.3942 -0.9450 0.1534 3.1709 0.3338 0.4235 0.1606 1.4421 0.0388 1.0870 0.0760</span> +<span class="r-out co"><span class="r-pr">#></span> 243: 92.2296 -5.8489 -0.0708 2.3934 -0.9446 0.1531 3.1689 0.3342 0.4230 0.1605 1.4423 0.0387 1.0876 0.0760</span> +<span class="r-out co"><span class="r-pr">#></span> 244: 92.2311 -5.8446 -0.0715 2.3929 -0.9443 0.1528 3.1630 0.3349 0.4228 0.1604 1.4429 0.0387 1.0916 0.0759</span> +<span class="r-out co"><span class="r-pr">#></span> 245: 92.2338 -5.8421 -0.0718 2.3924 -0.9443 0.1528 3.1616 0.3352 0.4224 0.1610 1.4438 0.0387 1.0980 0.0755</span> +<span class="r-out co"><span class="r-pr">#></span> 246: 92.2361 -5.8389 -0.0721 2.3918 -0.9439 0.1525 3.1525 0.3354 0.4216 0.1620 1.4438 0.0388 1.1018 0.0753</span> +<span class="r-out co"><span class="r-pr">#></span> 247: 92.2374 -5.8388 -0.0724 2.3917 -0.9434 0.1510 3.1605 0.3356 0.4212 0.1629 1.4438 0.0389 1.1050 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 248: 92.2360 -5.8367 -0.0728 2.3918 -0.9432 0.1505 3.1559 0.3360 0.4207 0.1638 1.4437 0.0389 1.1090 0.0748</span> +<span class="r-out co"><span class="r-pr">#></span> 249: 92.2361 -5.8351 -0.0732 2.3914 -0.9435 0.1499 3.1521 0.3363 0.4204 0.1646 1.4433 0.0389 1.1117 0.0748</span> +<span class="r-out co"><span class="r-pr">#></span> 250: 92.2353 -5.8349 -0.0733 2.3906 -0.9436 0.1502 3.1607 0.3365 0.4202 0.1646 1.4457 0.0388 1.1107 0.0749</span> +<span class="r-out co"><span class="r-pr">#></span> 251: 92.2343 -5.8318 -0.0736 2.3903 -0.9430 0.1494 3.1513 0.3367 0.4201 0.1648 1.4453 0.0387 1.1093 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 252: 92.2356 -5.8244 -0.0739 2.3895 -0.9424 0.1477 3.1240 0.3369 0.4200 0.1651 1.4460 0.0386 1.1083 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 253: 92.2367 -5.8188 -0.0742 2.3890 -0.9423 0.1465 3.1025 0.3369 0.4200 0.1649 1.4477 0.0385 1.1092 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 254: 92.2392 -5.8154 -0.0747 2.3880 -0.9421 0.1458 3.0888 0.3372 0.4195 0.1644 1.4494 0.0384 1.1080 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 255: 92.2404 -5.8131 -0.0751 2.3870 -0.9417 0.1451 3.0778 0.3375 0.4191 0.1639 1.4501 0.0383 1.1070 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 256: 92.2408 -5.8109 -0.0753 2.3867 -0.9413 0.1445 3.0740 0.3376 0.4192 0.1633 1.4510 0.0382 1.1064 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 257: 92.2413 -5.8066 -0.0754 2.3866 -0.9409 0.1446 3.0636 0.3376 0.4191 0.1628 1.4522 0.0382 1.1080 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 258: 92.2412 -5.8035 -0.0754 2.3869 -0.9404 0.1436 3.0502 0.3372 0.4191 0.1623 1.4534 0.0381 1.1057 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 259: 92.2399 -5.7996 -0.0753 2.3871 -0.9399 0.1427 3.0357 0.3370 0.4195 0.1621 1.4540 0.0380 1.1037 0.0752</span> +<span class="r-out co"><span class="r-pr">#></span> 260: 92.2389 -5.7955 -0.0755 2.3872 -0.9391 0.1420 3.0251 0.3366 0.4199 0.1619 1.4555 0.0380 1.1041 0.0752</span> +<span class="r-out co"><span class="r-pr">#></span> 261: 92.2378 -5.7941 -0.0755 2.3875 -0.9385 0.1412 3.0240 0.3362 0.4201 0.1613 1.4575 0.0380 1.1048 0.0751</span> +<span class="r-out co"><span class="r-pr">#></span> 262: 92.2361 -5.7920 -0.0756 2.3879 -0.9379 0.1407 3.0182 0.3358 0.4205 0.1607 1.4581 0.0381 1.1047 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 263: 92.2338 -5.7891 -0.0754 2.3883 -0.9375 0.1407 3.0072 0.3356 0.4211 0.1603 1.4585 0.0381 1.1041 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 264: 92.2313 -5.7882 -0.0752 2.3886 -0.9371 0.1407 3.0009 0.3355 0.4217 0.1601 1.4574 0.0381 1.1036 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 265: 92.2312 -5.7843 -0.0752 2.3883 -0.9372 0.1402 2.9872 0.3358 0.4220 0.1599 1.4577 0.0381 1.1026 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 266: 92.2312 -5.7800 -0.0753 2.3880 -0.9370 0.1396 2.9708 0.3363 0.4223 0.1597 1.4584 0.0381 1.1019 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 267: 92.2306 -5.7785 -0.0755 2.3878 -0.9372 0.1397 2.9619 0.3368 0.4227 0.1595 1.4578 0.0381 1.1021 0.0750</span> +<span class="r-out co"><span class="r-pr">#></span> 268: 92.2287 -5.7803 -0.0758 2.3870 -0.9372 0.1394 2.9777 0.3375 0.4226 0.1594 1.4578 0.0380 1.1032 0.0749</span> +<span class="r-out co"><span class="r-pr">#></span> 269: 92.2265 -5.7804 -0.0761 2.3865 -0.9371 0.1399 2.9816 0.3382 0.4226 0.1592 1.4589 0.0380 1.1058 0.0747</span> +<span class="r-out co"><span class="r-pr">#></span> 270: 92.2236 -5.7811 -0.0765 2.3860 -0.9369 0.1411 2.9893 0.3386 0.4227 0.1591 1.4597 0.0380 1.1081 0.0745</span> +<span class="r-out co"><span class="r-pr">#></span> 271: 92.2211 -5.7793 -0.0769 2.3852 -0.9365 0.1421 2.9888 0.3390 0.4228 0.1591 1.4606 0.0379 1.1083 0.0745</span> +<span class="r-out co"><span class="r-pr">#></span> 272: 92.2187 -5.7773 -0.0773 2.3845 -0.9361 0.1423 2.9810 0.3396 0.4232 0.1589 1.4617 0.0378 1.1076 0.0746</span> +<span class="r-out co"><span class="r-pr">#></span> 273: 92.2164 -5.7769 -0.0776 2.3838 -0.9356 0.1427 2.9809 0.3402 0.4240 0.1589 1.4615 0.0378 1.1073 0.0746</span> +<span class="r-out co"><span class="r-pr">#></span> 274: 92.2145 -5.7763 -0.0778 2.3836 -0.9355 0.1434 2.9795 0.3407 0.4248 0.1589 1.4615 0.0378 1.1069 0.0746</span> +<span class="r-out co"><span class="r-pr">#></span> 275: 92.2133 -5.7762 -0.0779 2.3836 -0.9352 0.1436 2.9837 0.3410 0.4253 0.1589 1.4621 0.0378 1.1064 0.0746</span> +<span class="r-out co"><span class="r-pr">#></span> 276: 92.2123 -5.7764 -0.0781 2.3835 -0.9348 0.1431 2.9889 0.3414 0.4255 0.1589 1.4632 0.0378 1.1073 0.0746</span> +<span class="r-out co"><span class="r-pr">#></span> 277: 92.2113 -5.7771 -0.0781 2.3839 -0.9347 0.1423 2.9925 0.3423 0.4264 0.1589 1.4630 0.0378 1.1104 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 278: 92.2099 -5.7774 -0.0780 2.3841 -0.9349 0.1418 2.9927 0.3429 0.4270 0.1590 1.4634 0.0378 1.1127 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 279: 92.2087 -5.7798 -0.0779 2.3844 -0.9352 0.1413 2.9997 0.3437 0.4276 0.1590 1.4630 0.0378 1.1133 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 280: 92.2077 -5.7802 -0.0778 2.3841 -0.9358 0.1407 2.9971 0.3445 0.4284 0.1586 1.4634 0.0378 1.1136 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 281: 92.2061 -5.7814 -0.0777 2.3837 -0.9362 0.1401 3.0004 0.3452 0.4291 0.1582 1.4629 0.0378 1.1133 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 282: 92.2058 -5.7802 -0.0777 2.3834 -0.9363 0.1386 2.9994 0.3459 0.4297 0.1579 1.4634 0.0378 1.1126 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 283: 92.2057 -5.7780 -0.0778 2.3828 -0.9361 0.1376 2.9917 0.3469 0.4298 0.1576 1.4645 0.0378 1.1147 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 284: 92.2051 -5.7788 -0.0780 2.3824 -0.9360 0.1367 2.9968 0.3479 0.4300 0.1573 1.4647 0.0378 1.1149 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 285: 92.2041 -5.7793 -0.0782 2.3821 -0.9362 0.1359 2.9941 0.3487 0.4302 0.1573 1.4653 0.0378 1.1164 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 286: 92.2040 -5.7803 -0.0783 2.3819 -0.9364 0.1352 2.9957 0.3495 0.4304 0.1573 1.4655 0.0378 1.1180 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 287: 92.2044 -5.7809 -0.0784 2.3817 -0.9365 0.1348 2.9961 0.3502 0.4304 0.1572 1.4657 0.0379 1.1178 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 288: 92.2043 -5.7835 -0.0785 2.3814 -0.9366 0.1350 3.0073 0.3509 0.4304 0.1572 1.4658 0.0379 1.1184 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 289: 92.2041 -5.7845 -0.0787 2.3809 -0.9364 0.1347 3.0126 0.3516 0.4304 0.1571 1.4653 0.0379 1.1190 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 290: 92.2032 -5.7852 -0.0788 2.3807 -0.9363 0.1349 3.0161 0.3521 0.4304 0.1568 1.4656 0.0379 1.1191 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 291: 92.2019 -5.7848 -0.0790 2.3802 -0.9363 0.1356 3.0155 0.3528 0.4300 0.1565 1.4664 0.0380 1.1210 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 292: 92.2012 -5.7846 -0.0792 2.3799 -0.9363 0.1361 3.0167 0.3535 0.4296 0.1563 1.4670 0.0380 1.1223 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 293: 92.2007 -5.7845 -0.0793 2.3795 -0.9363 0.1365 3.0175 0.3542 0.4291 0.1561 1.4681 0.0380 1.1236 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 294: 92.2009 -5.7850 -0.0795 2.3791 -0.9360 0.1365 3.0189 0.3550 0.4287 0.1560 1.4682 0.0380 1.1243 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 295: 92.2009 -5.7865 -0.0797 2.3786 -0.9360 0.1360 3.0279 0.3556 0.4286 0.1558 1.4689 0.0380 1.1243 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 296: 92.2007 -5.7878 -0.0798 2.3781 -0.9362 0.1358 3.0345 0.3562 0.4283 0.1555 1.4694 0.0379 1.1247 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 297: 92.1992 -5.7891 -0.0801 2.3774 -0.9364 0.1358 3.0403 0.3568 0.4278 0.1554 1.4699 0.0379 1.1267 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 298: 92.1978 -5.7892 -0.0803 2.3768 -0.9366 0.1357 3.0383 0.3573 0.4274 0.1553 1.4706 0.0378 1.1276 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 299: 92.1968 -5.7906 -0.0805 2.3763 -0.9369 0.1353 3.0408 0.3579 0.4269 0.1553 1.4712 0.0378 1.1282 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 300: 92.1954 -5.7929 -0.0807 2.3760 -0.9369 0.1352 3.0477 0.3583 0.4265 0.1551 1.4716 0.0379 1.1286 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 301: 92.1941 -5.7934 -0.0809 2.3757 -0.9369 0.1352 3.0483 0.3588 0.4261 0.1548 1.4727 0.0378 1.1288 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 302: 92.1929 -5.7949 -0.0811 2.3754 -0.9370 0.1354 3.0560 0.3592 0.4256 0.1548 1.4728 0.0379 1.1296 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 303: 92.1919 -5.7972 -0.0813 2.3751 -0.9368 0.1352 3.0671 0.3597 0.4250 0.1550 1.4730 0.0379 1.1302 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 304: 92.1906 -5.8018 -0.0814 2.3750 -0.9368 0.1349 3.0935 0.3602 0.4245 0.1552 1.4731 0.0379 1.1314 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 305: 92.1897 -5.8063 -0.0817 2.3744 -0.9370 0.1350 3.1211 0.3606 0.4238 0.1554 1.4727 0.0379 1.1323 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 306: 92.1896 -5.8116 -0.0820 2.3740 -0.9373 0.1347 3.1571 0.3610 0.4233 0.1555 1.4727 0.0379 1.1351 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 307: 92.1895 -5.8156 -0.0822 2.3735 -0.9373 0.1341 3.1826 0.3613 0.4226 0.1552 1.4741 0.0379 1.1374 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 308: 92.1899 -5.8202 -0.0824 2.3732 -0.9376 0.1338 3.2124 0.3617 0.4220 0.1554 1.4745 0.0379 1.1408 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 309: 92.1903 -5.8232 -0.0827 2.3728 -0.9377 0.1337 3.2330 0.3620 0.4213 0.1554 1.4749 0.0379 1.1419 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 310: 92.1902 -5.8249 -0.0828 2.3727 -0.9378 0.1335 3.2463 0.3621 0.4207 0.1554 1.4752 0.0379 1.1435 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 311: 92.1910 -5.8267 -0.0828 2.3726 -0.9378 0.1335 3.2581 0.3623 0.4200 0.1554 1.4754 0.0379 1.1441 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 312: 92.1918 -5.8271 -0.0829 2.3726 -0.9378 0.1333 3.2567 0.3624 0.4195 0.1552 1.4751 0.0380 1.1432 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 313: 92.1926 -5.8260 -0.0829 2.3725 -0.9380 0.1334 3.2497 0.3626 0.4190 0.1552 1.4751 0.0380 1.1434 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 314: 92.1934 -5.8256 -0.0829 2.3724 -0.9381 0.1330 3.2426 0.3628 0.4185 0.1553 1.4746 0.0380 1.1441 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 315: 92.1938 -5.8237 -0.0829 2.3724 -0.9384 0.1326 3.2327 0.3630 0.4179 0.1555 1.4746 0.0380 1.1468 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 316: 92.1950 -5.8235 -0.0829 2.3722 -0.9385 0.1324 3.2283 0.3631 0.4172 0.1557 1.4745 0.0380 1.1476 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 317: 92.1963 -5.8239 -0.0829 2.3722 -0.9385 0.1322 3.2260 0.3633 0.4167 0.1560 1.4741 0.0380 1.1481 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 318: 92.1975 -5.8242 -0.0829 2.3722 -0.9387 0.1321 3.2240 0.3634 0.4163 0.1559 1.4740 0.0380 1.1477 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 319: 92.1990 -5.8250 -0.0829 2.3721 -0.9387 0.1320 3.2215 0.3634 0.4159 0.1560 1.4736 0.0381 1.1496 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 320: 92.2003 -5.8256 -0.0829 2.3722 -0.9386 0.1322 3.2199 0.3635 0.4155 0.1561 1.4730 0.0381 1.1508 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 321: 92.2018 -5.8249 -0.0829 2.3723 -0.9386 0.1326 3.2150 0.3635 0.4151 0.1562 1.4727 0.0381 1.1514 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 322: 92.2031 -5.8239 -0.0829 2.3724 -0.9386 0.1333 3.2081 0.3635 0.4147 0.1561 1.4729 0.0381 1.1527 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 323: 92.2045 -5.8244 -0.0829 2.3725 -0.9384 0.1336 3.2065 0.3635 0.4143 0.1562 1.4729 0.0381 1.1541 0.0716</span> +<span class="r-out co"><span class="r-pr">#></span> 324: 92.2060 -5.8228 -0.0828 2.3726 -0.9383 0.1339 3.1996 0.3635 0.4139 0.1562 1.4729 0.0382 1.1562 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 325: 92.2071 -5.8212 -0.0828 2.3727 -0.9383 0.1339 3.1921 0.3636 0.4135 0.1563 1.4733 0.0382 1.1580 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 326: 92.2083 -5.8201 -0.0826 2.3728 -0.9382 0.1340 3.1888 0.3639 0.4134 0.1562 1.4734 0.0382 1.1587 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 327: 92.2095 -5.8185 -0.0825 2.3729 -0.9379 0.1340 3.1831 0.3641 0.4134 0.1562 1.4737 0.0382 1.1592 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 328: 92.2105 -5.8188 -0.0823 2.3731 -0.9379 0.1338 3.1836 0.3643 0.4132 0.1561 1.4736 0.0383 1.1589 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 329: 92.2115 -5.8182 -0.0821 2.3732 -0.9381 0.1339 3.1807 0.3646 0.4129 0.1561 1.4737 0.0383 1.1585 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 330: 92.2127 -5.8181 -0.0819 2.3734 -0.9381 0.1338 3.1827 0.3648 0.4127 0.1563 1.4735 0.0383 1.1578 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 331: 92.2134 -5.8180 -0.0815 2.3739 -0.9381 0.1340 3.1837 0.3647 0.4128 0.1566 1.4735 0.0383 1.1575 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 332: 92.2136 -5.8184 -0.0811 2.3746 -0.9379 0.1340 3.1847 0.3647 0.4130 0.1570 1.4728 0.0384 1.1577 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 333: 92.2133 -5.8180 -0.0807 2.3753 -0.9376 0.1340 3.1853 0.3646 0.4132 0.1572 1.4725 0.0384 1.1573 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 334: 92.2136 -5.8173 -0.0803 2.3760 -0.9374 0.1342 3.1838 0.3645 0.4133 0.1576 1.4720 0.0385 1.1570 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 335: 92.2139 -5.8187 -0.0800 2.3769 -0.9372 0.1344 3.1947 0.3643 0.4135 0.1576 1.4714 0.0386 1.1567 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 336: 92.2134 -5.8198 -0.0796 2.3777 -0.9370 0.1348 3.2008 0.3641 0.4135 0.1577 1.4706 0.0387 1.1557 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 337: 92.2130 -5.8201 -0.0792 2.3784 -0.9370 0.1357 3.2050 0.3640 0.4137 0.1579 1.4703 0.0388 1.1558 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 338: 92.2130 -5.8190 -0.0787 2.3791 -0.9368 0.1362 3.2036 0.3638 0.4139 0.1580 1.4708 0.0388 1.1558 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 339: 92.2132 -5.8177 -0.0783 2.3798 -0.9368 0.1369 3.2006 0.3637 0.4142 0.1581 1.4712 0.0388 1.1551 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 340: 92.2137 -5.8167 -0.0778 2.3806 -0.9366 0.1376 3.1984 0.3636 0.4143 0.1581 1.4712 0.0388 1.1540 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 341: 92.2141 -5.8145 -0.0773 2.3814 -0.9364 0.1378 3.1916 0.3635 0.4142 0.1581 1.4712 0.0389 1.1529 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 342: 92.2142 -5.8123 -0.0769 2.3821 -0.9364 0.1383 3.1840 0.3634 0.4142 0.1581 1.4718 0.0389 1.1513 0.0716</span> +<span class="r-out co"><span class="r-pr">#></span> 343: 92.2139 -5.8109 -0.0764 2.3830 -0.9364 0.1389 3.1806 0.3632 0.4142 0.1581 1.4721 0.0389 1.1501 0.0716</span> +<span class="r-out co"><span class="r-pr">#></span> 344: 92.2137 -5.8117 -0.0759 2.3839 -0.9366 0.1390 3.1830 0.3631 0.4144 0.1582 1.4711 0.0390 1.1492 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 345: 92.2133 -5.8118 -0.0754 2.3849 -0.9368 0.1391 3.1827 0.3630 0.4146 0.1582 1.4703 0.0391 1.1488 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 346: 92.2127 -5.8113 -0.0748 2.3858 -0.9369 0.1389 3.1793 0.3629 0.4147 0.1581 1.4700 0.0391 1.1475 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 347: 92.2121 -5.8107 -0.0743 2.3867 -0.9371 0.1386 3.1748 0.3628 0.4149 0.1579 1.4701 0.0392 1.1463 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 348: 92.2106 -5.8109 -0.0738 2.3876 -0.9374 0.1385 3.1726 0.3626 0.4151 0.1577 1.4704 0.0392 1.1453 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 349: 92.2096 -5.8111 -0.0732 2.3883 -0.9377 0.1382 3.1703 0.3626 0.4151 0.1575 1.4705 0.0392 1.1448 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 350: 92.2088 -5.8108 -0.0727 2.3890 -0.9378 0.1380 3.1674 0.3625 0.4152 0.1574 1.4704 0.0392 1.1439 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 351: 92.2077 -5.8103 -0.0722 2.3899 -0.9379 0.1379 3.1634 0.3623 0.4154 0.1572 1.4701 0.0393 1.1432 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 352: 92.2069 -5.8103 -0.0718 2.3906 -0.9381 0.1380 3.1626 0.3623 0.4154 0.1570 1.4701 0.0393 1.1425 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 353: 92.2058 -5.8107 -0.0714 2.3913 -0.9381 0.1382 3.1629 0.3624 0.4154 0.1570 1.4695 0.0394 1.1426 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 354: 92.2046 -5.8102 -0.0710 2.3921 -0.9381 0.1384 3.1576 0.3624 0.4154 0.1571 1.4691 0.0394 1.1424 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 355: 92.2034 -5.8084 -0.0707 2.3928 -0.9381 0.1388 3.1501 0.3624 0.4154 0.1570 1.4686 0.0395 1.1414 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 356: 92.2027 -5.8079 -0.0703 2.3935 -0.9382 0.1392 3.1463 0.3626 0.4155 0.1569 1.4682 0.0396 1.1405 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 357: 92.2019 -5.8084 -0.0698 2.3943 -0.9382 0.1390 3.1444 0.3628 0.4156 0.1569 1.4665 0.0397 1.1403 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 358: 92.2014 -5.8085 -0.0694 2.3950 -0.9381 0.1389 3.1413 0.3630 0.4158 0.1569 1.4662 0.0398 1.1398 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 359: 92.2005 -5.8091 -0.0689 2.3956 -0.9383 0.1387 3.1393 0.3633 0.4159 0.1570 1.4664 0.0398 1.1401 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 360: 92.1994 -5.8091 -0.0685 2.3962 -0.9385 0.1385 3.1362 0.3635 0.4159 0.1572 1.4664 0.0398 1.1413 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 361: 92.1983 -5.8094 -0.0682 2.3966 -0.9386 0.1384 3.1340 0.3638 0.4159 0.1573 1.4669 0.0398 1.1420 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 362: 92.1976 -5.8086 -0.0678 2.3971 -0.9389 0.1380 3.1277 0.3639 0.4160 0.1573 1.4671 0.0398 1.1414 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 363: 92.1967 -5.8081 -0.0675 2.3976 -0.9389 0.1377 3.1239 0.3641 0.4161 0.1573 1.4669 0.0399 1.1412 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 364: 92.1960 -5.8073 -0.0671 2.3982 -0.9390 0.1373 3.1208 0.3643 0.4161 0.1572 1.4668 0.0399 1.1411 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 365: 92.1958 -5.8066 -0.0667 2.3988 -0.9389 0.1369 3.1164 0.3645 0.4160 0.1572 1.4672 0.0399 1.1416 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 366: 92.1956 -5.8063 -0.0664 2.3992 -0.9390 0.1364 3.1127 0.3650 0.4156 0.1573 1.4674 0.0399 1.1425 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 367: 92.1952 -5.8056 -0.0661 2.3996 -0.9389 0.1361 3.1082 0.3652 0.4155 0.1574 1.4675 0.0399 1.1416 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 368: 92.1948 -5.8059 -0.0658 2.4001 -0.9389 0.1359 3.1068 0.3655 0.4154 0.1575 1.4671 0.0399 1.1406 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 369: 92.1948 -5.8064 -0.0655 2.4005 -0.9388 0.1360 3.1055 0.3658 0.4152 0.1576 1.4669 0.0399 1.1408 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 370: 92.1951 -5.8072 -0.0652 2.4010 -0.9389 0.1361 3.1060 0.3660 0.4151 0.1576 1.4669 0.0399 1.1406 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 371: 92.1956 -5.8080 -0.0649 2.4015 -0.9390 0.1362 3.1095 0.3662 0.4150 0.1576 1.4669 0.0400 1.1411 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 372: 92.1962 -5.8096 -0.0645 2.4020 -0.9390 0.1363 3.1168 0.3665 0.4149 0.1576 1.4667 0.0400 1.1411 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 373: 92.1968 -5.8098 -0.0642 2.4025 -0.9392 0.1363 3.1154 0.3666 0.4147 0.1576 1.4664 0.0400 1.1418 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 374: 92.1972 -5.8098 -0.0640 2.4029 -0.9395 0.1363 3.1117 0.3667 0.4146 0.1576 1.4661 0.0401 1.1421 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 375: 92.1979 -5.8101 -0.0637 2.4032 -0.9397 0.1364 3.1090 0.3668 0.4143 0.1577 1.4654 0.0401 1.1425 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 376: 92.1981 -5.8106 -0.0635 2.4035 -0.9399 0.1363 3.1084 0.3669 0.4142 0.1576 1.4650 0.0401 1.1423 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 377: 92.1986 -5.8104 -0.0633 2.4039 -0.9399 0.1360 3.1053 0.3670 0.4142 0.1576 1.4645 0.0402 1.1424 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 378: 92.1989 -5.8104 -0.0631 2.4043 -0.9399 0.1358 3.1026 0.3671 0.4142 0.1577 1.4638 0.0402 1.1421 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 379: 92.1990 -5.8114 -0.0628 2.4047 -0.9399 0.1355 3.1068 0.3671 0.4141 0.1577 1.4636 0.0402 1.1413 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 380: 92.1989 -5.8119 -0.0627 2.4048 -0.9400 0.1351 3.1095 0.3673 0.4136 0.1577 1.4634 0.0402 1.1413 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 381: 92.1989 -5.8127 -0.0627 2.4048 -0.9400 0.1349 3.1152 0.3676 0.4131 0.1577 1.4631 0.0403 1.1408 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 382: 92.1994 -5.8126 -0.0627 2.4049 -0.9399 0.1348 3.1188 0.3678 0.4126 0.1576 1.4635 0.0403 1.1403 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 383: 92.2000 -5.8129 -0.0626 2.4049 -0.9397 0.1346 3.1256 0.3681 0.4120 0.1576 1.4637 0.0403 1.1396 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 384: 92.2006 -5.8133 -0.0626 2.4050 -0.9396 0.1347 3.1290 0.3683 0.4115 0.1575 1.4641 0.0402 1.1389 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 385: 92.2015 -5.8131 -0.0626 2.4050 -0.9394 0.1350 3.1287 0.3686 0.4110 0.1575 1.4642 0.0402 1.1382 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 386: 92.2023 -5.8140 -0.0625 2.4049 -0.9391 0.1349 3.1324 0.3690 0.4104 0.1574 1.4647 0.0402 1.1374 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 387: 92.2030 -5.8147 -0.0625 2.4050 -0.9390 0.1349 3.1345 0.3693 0.4099 0.1572 1.4652 0.0402 1.1366 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 388: 92.2040 -5.8157 -0.0625 2.4050 -0.9389 0.1349 3.1381 0.3696 0.4094 0.1570 1.4652 0.0402 1.1362 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 389: 92.2051 -5.8156 -0.0625 2.4051 -0.9387 0.1349 3.1373 0.3699 0.4090 0.1570 1.4653 0.0402 1.1354 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 390: 92.2063 -5.8152 -0.0625 2.4051 -0.9386 0.1349 3.1350 0.3702 0.4087 0.1570 1.4655 0.0402 1.1345 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 391: 92.2076 -5.8160 -0.0625 2.4051 -0.9384 0.1350 3.1380 0.3705 0.4083 0.1571 1.4656 0.0402 1.1341 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 392: 92.2086 -5.8166 -0.0626 2.4049 -0.9384 0.1349 3.1397 0.3707 0.4081 0.1572 1.4658 0.0402 1.1345 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 393: 92.2095 -5.8168 -0.0626 2.4047 -0.9383 0.1348 3.1405 0.3708 0.4080 0.1573 1.4659 0.0402 1.1344 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 394: 92.2107 -5.8174 -0.0627 2.4045 -0.9382 0.1347 3.1433 0.3710 0.4079 0.1575 1.4660 0.0401 1.1342 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 395: 92.2118 -5.8174 -0.0628 2.4043 -0.9380 0.1346 3.1437 0.3711 0.4078 0.1575 1.4661 0.0401 1.1343 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 396: 92.2127 -5.8170 -0.0629 2.4041 -0.9379 0.1344 3.1424 0.3712 0.4077 0.1575 1.4664 0.0401 1.1342 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 397: 92.2137 -5.8161 -0.0630 2.4040 -0.9376 0.1342 3.1386 0.3713 0.4076 0.1577 1.4667 0.0401 1.1341 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 398: 92.2146 -5.8152 -0.0633 2.4036 -0.9374 0.1341 3.1344 0.3713 0.4075 0.1578 1.4671 0.0401 1.1334 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 399: 92.2157 -5.8138 -0.0635 2.4032 -0.9373 0.1340 3.1296 0.3714 0.4074 0.1578 1.4678 0.0401 1.1336 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 400: 92.2165 -5.8131 -0.0638 2.4027 -0.9372 0.1340 3.1262 0.3715 0.4072 0.1579 1.4681 0.0400 1.1332 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 401: 92.2173 -5.8118 -0.0641 2.4022 -0.9372 0.1341 3.1220 0.3716 0.4069 0.1579 1.4686 0.0400 1.1339 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 402: 92.2181 -5.8107 -0.0643 2.4018 -0.9370 0.1344 3.1192 0.3718 0.4065 0.1580 1.4694 0.0400 1.1338 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 403: 92.2190 -5.8099 -0.0646 2.4013 -0.9371 0.1348 3.1166 0.3720 0.4061 0.1581 1.4700 0.0400 1.1344 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 404: 92.2198 -5.8104 -0.0649 2.4008 -0.9372 0.1348 3.1161 0.3723 0.4058 0.1582 1.4704 0.0399 1.1357 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 405: 92.2203 -5.8107 -0.0652 2.4004 -0.9372 0.1348 3.1177 0.3725 0.4055 0.1582 1.4705 0.0400 1.1358 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 406: 92.2204 -5.8103 -0.0653 2.4002 -0.9371 0.1348 3.1157 0.3724 0.4051 0.1582 1.4709 0.0400 1.1361 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 407: 92.2201 -5.8094 -0.0655 2.4001 -0.9369 0.1348 3.1121 0.3724 0.4048 0.1583 1.4713 0.0400 1.1360 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 408: 92.2201 -5.8087 -0.0657 2.3999 -0.9368 0.1350 3.1085 0.3724 0.4044 0.1582 1.4714 0.0400 1.1360 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 409: 92.2201 -5.8083 -0.0658 2.3998 -0.9365 0.1355 3.1073 0.3724 0.4043 0.1582 1.4713 0.0401 1.1358 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 410: 92.2196 -5.8094 -0.0659 2.3996 -0.9365 0.1361 3.1123 0.3724 0.4041 0.1582 1.4712 0.0401 1.1357 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 411: 92.2192 -5.8099 -0.0661 2.3994 -0.9366 0.1363 3.1168 0.3724 0.4038 0.1582 1.4715 0.0401 1.1354 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 412: 92.2187 -5.8105 -0.0662 2.3993 -0.9365 0.1365 3.1215 0.3725 0.4035 0.1582 1.4716 0.0401 1.1359 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 413: 92.2185 -5.8109 -0.0663 2.3992 -0.9365 0.1367 3.1268 0.3725 0.4031 0.1583 1.4719 0.0401 1.1357 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 414: 92.2183 -5.8111 -0.0665 2.3987 -0.9365 0.1370 3.1286 0.3727 0.4026 0.1582 1.4724 0.0400 1.1349 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 415: 92.2181 -5.8122 -0.0667 2.3983 -0.9366 0.1370 3.1351 0.3729 0.4021 0.1581 1.4726 0.0400 1.1341 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 416: 92.2180 -5.8133 -0.0669 2.3979 -0.9367 0.1372 3.1409 0.3731 0.4015 0.1578 1.4734 0.0400 1.1333 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 417: 92.2176 -5.8138 -0.0671 2.3976 -0.9368 0.1374 3.1426 0.3733 0.4009 0.1576 1.4739 0.0400 1.1325 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 418: 92.2173 -5.8150 -0.0673 2.3973 -0.9369 0.1376 3.1479 0.3735 0.4003 0.1575 1.4740 0.0400 1.1316 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 419: 92.2174 -5.8154 -0.0674 2.3970 -0.9369 0.1375 3.1497 0.3736 0.3998 0.1574 1.4741 0.0400 1.1314 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 420: 92.2175 -5.8154 -0.0676 2.3968 -0.9369 0.1375 3.1489 0.3737 0.3993 0.1574 1.4742 0.0400 1.1315 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 421: 92.2176 -5.8154 -0.0678 2.3964 -0.9369 0.1374 3.1485 0.3739 0.3989 0.1573 1.4743 0.0400 1.1312 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 422: 92.2174 -5.8155 -0.0680 2.3961 -0.9370 0.1375 3.1483 0.3741 0.3985 0.1572 1.4744 0.0400 1.1309 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 423: 92.2170 -5.8156 -0.0681 2.3958 -0.9371 0.1375 3.1481 0.3742 0.3980 0.1571 1.4741 0.0400 1.1308 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 424: 92.2169 -5.8168 -0.0683 2.3956 -0.9372 0.1374 3.1524 0.3744 0.3976 0.1571 1.4740 0.0400 1.1316 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 425: 92.2167 -5.8171 -0.0685 2.3954 -0.9372 0.1373 3.1520 0.3744 0.3972 0.1571 1.4736 0.0401 1.1317 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 426: 92.2164 -5.8170 -0.0687 2.3951 -0.9372 0.1373 3.1502 0.3745 0.3968 0.1570 1.4734 0.0401 1.1320 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 427: 92.2166 -5.8169 -0.0688 2.3949 -0.9372 0.1372 3.1480 0.3745 0.3964 0.1570 1.4734 0.0401 1.1317 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 428: 92.2166 -5.8170 -0.0689 2.3948 -0.9374 0.1371 3.1460 0.3745 0.3959 0.1570 1.4735 0.0401 1.1315 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 429: 92.2162 -5.8171 -0.0691 2.3946 -0.9374 0.1369 3.1446 0.3745 0.3954 0.1570 1.4736 0.0401 1.1316 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 430: 92.2158 -5.8178 -0.0692 2.3944 -0.9375 0.1370 3.1464 0.3745 0.3950 0.1570 1.4736 0.0401 1.1314 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 431: 92.2153 -5.8180 -0.0693 2.3942 -0.9375 0.1371 3.1470 0.3745 0.3946 0.1570 1.4735 0.0401 1.1314 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 432: 92.2150 -5.8182 -0.0695 2.3940 -0.9375 0.1372 3.1477 0.3746 0.3942 0.1570 1.4735 0.0401 1.1315 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 433: 92.2145 -5.8189 -0.0696 2.3938 -0.9375 0.1374 3.1512 0.3746 0.3938 0.1571 1.4736 0.0400 1.1323 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 434: 92.2141 -5.8186 -0.0697 2.3936 -0.9373 0.1376 3.1530 0.3746 0.3933 0.1571 1.4736 0.0400 1.1330 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 435: 92.2133 -5.8187 -0.0699 2.3934 -0.9373 0.1381 3.1571 0.3747 0.3929 0.1570 1.4738 0.0400 1.1325 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 436: 92.2129 -5.8180 -0.0700 2.3932 -0.9374 0.1380 3.1544 0.3746 0.3925 0.1570 1.4740 0.0400 1.1332 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 437: 92.2122 -5.8186 -0.0702 2.3930 -0.9375 0.1380 3.1574 0.3746 0.3921 0.1570 1.4739 0.0400 1.1342 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 438: 92.2114 -5.8187 -0.0703 2.3928 -0.9376 0.1380 3.1583 0.3745 0.3918 0.1569 1.4740 0.0400 1.1346 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 439: 92.2104 -5.8181 -0.0705 2.3925 -0.9377 0.1381 3.1568 0.3744 0.3914 0.1568 1.4743 0.0400 1.1352 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 440: 92.2095 -5.8178 -0.0706 2.3923 -0.9377 0.1381 3.1555 0.3743 0.3910 0.1566 1.4745 0.0400 1.1349 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 441: 92.2088 -5.8176 -0.0707 2.3923 -0.9378 0.1381 3.1559 0.3742 0.3907 0.1565 1.4748 0.0400 1.1349 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 442: 92.2081 -5.8172 -0.0708 2.3921 -0.9379 0.1383 3.1539 0.3741 0.3903 0.1564 1.4754 0.0400 1.1350 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 443: 92.2074 -5.8171 -0.0709 2.3920 -0.9380 0.1387 3.1526 0.3740 0.3901 0.1563 1.4756 0.0400 1.1349 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 444: 92.2068 -5.8175 -0.0711 2.3918 -0.9380 0.1390 3.1533 0.3739 0.3898 0.1562 1.4758 0.0400 1.1353 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 445: 92.2061 -5.8180 -0.0712 2.3915 -0.9382 0.1394 3.1529 0.3737 0.3896 0.1562 1.4758 0.0400 1.1355 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 446: 92.2054 -5.8177 -0.0714 2.3912 -0.9384 0.1398 3.1496 0.3735 0.3894 0.1562 1.4760 0.0399 1.1367 0.0716</span> +<span class="r-out co"><span class="r-pr">#></span> 447: 92.2051 -5.8180 -0.0716 2.3910 -0.9385 0.1400 3.1484 0.3734 0.3891 0.1563 1.4762 0.0399 1.1370 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 448: 92.2053 -5.8189 -0.0717 2.3909 -0.9387 0.1405 3.1499 0.3732 0.3889 0.1563 1.4764 0.0399 1.1377 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 449: 92.2054 -5.8195 -0.0718 2.3908 -0.9388 0.1411 3.1497 0.3730 0.3887 0.1562 1.4768 0.0399 1.1382 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 450: 92.2054 -5.8205 -0.0719 2.3906 -0.9390 0.1417 3.1528 0.3728 0.3885 0.1562 1.4769 0.0399 1.1378 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 451: 92.2053 -5.8213 -0.0720 2.3905 -0.9391 0.1423 3.1544 0.3725 0.3883 0.1561 1.4774 0.0399 1.1379 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 452: 92.2054 -5.8218 -0.0720 2.3905 -0.9393 0.1426 3.1541 0.3722 0.3882 0.1560 1.4779 0.0398 1.1378 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 453: 92.2054 -5.8217 -0.0721 2.3903 -0.9395 0.1428 3.1530 0.3721 0.3880 0.1559 1.4785 0.0398 1.1378 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 454: 92.2053 -5.8214 -0.0722 2.3901 -0.9395 0.1431 3.1508 0.3720 0.3878 0.1559 1.4786 0.0398 1.1375 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 455: 92.2052 -5.8220 -0.0724 2.3898 -0.9396 0.1433 3.1519 0.3720 0.3875 0.1559 1.4791 0.0398 1.1379 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 456: 92.2053 -5.8230 -0.0727 2.3894 -0.9397 0.1434 3.1544 0.3720 0.3873 0.1560 1.4793 0.0398 1.1384 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 457: 92.2053 -5.8240 -0.0729 2.3889 -0.9398 0.1437 3.1568 0.3720 0.3869 0.1559 1.4793 0.0398 1.1393 0.0714</span> +<span class="r-out co"><span class="r-pr">#></span> 458: 92.2051 -5.8245 -0.0731 2.3885 -0.9399 0.1440 3.1571 0.3721 0.3865 0.1558 1.4797 0.0397 1.1404 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 459: 92.2045 -5.8246 -0.0732 2.3882 -0.9402 0.1442 3.1562 0.3721 0.3862 0.1558 1.4801 0.0397 1.1407 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 460: 92.2040 -5.8244 -0.0734 2.3878 -0.9403 0.1442 3.1536 0.3722 0.3859 0.1558 1.4806 0.0397 1.1406 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 461: 92.2030 -5.8245 -0.0736 2.3874 -0.9404 0.1444 3.1517 0.3722 0.3856 0.1557 1.4811 0.0397 1.1412 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 462: 92.2022 -5.8253 -0.0738 2.3870 -0.9405 0.1445 3.1531 0.3723 0.3853 0.1556 1.4817 0.0396 1.1425 0.0712</span> +<span class="r-out co"><span class="r-pr">#></span> 463: 92.2014 -5.8260 -0.0740 2.3866 -0.9405 0.1449 3.1545 0.3724 0.3849 0.1556 1.4823 0.0396 1.1441 0.0711</span> +<span class="r-out co"><span class="r-pr">#></span> 464: 92.2008 -5.8257 -0.0742 2.3862 -0.9405 0.1453 3.1522 0.3726 0.3845 0.1555 1.4828 0.0396 1.1451 0.0711</span> +<span class="r-out co"><span class="r-pr">#></span> 465: 92.2002 -5.8256 -0.0744 2.3859 -0.9404 0.1458 3.1511 0.3727 0.3842 0.1555 1.4830 0.0396 1.1459 0.0710</span> +<span class="r-out co"><span class="r-pr">#></span> 466: 92.1997 -5.8256 -0.0747 2.3855 -0.9403 0.1463 3.1516 0.3728 0.3839 0.1555 1.4834 0.0396 1.1476 0.0709</span> +<span class="r-out co"><span class="r-pr">#></span> 467: 92.1993 -5.8258 -0.0749 2.3850 -0.9404 0.1468 3.1521 0.3730 0.3836 0.1555 1.4835 0.0395 1.1490 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 468: 92.1990 -5.8259 -0.0752 2.3846 -0.9404 0.1473 3.1546 0.3731 0.3834 0.1555 1.4837 0.0395 1.1500 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 469: 92.1987 -5.8263 -0.0753 2.3844 -0.9403 0.1479 3.1598 0.3731 0.3831 0.1555 1.4839 0.0395 1.1504 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 470: 92.1987 -5.8267 -0.0755 2.3841 -0.9403 0.1482 3.1611 0.3730 0.3829 0.1555 1.4839 0.0395 1.1496 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 471: 92.1987 -5.8269 -0.0756 2.3839 -0.9404 0.1482 3.1627 0.3730 0.3826 0.1555 1.4839 0.0395 1.1492 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 472: 92.1983 -5.8269 -0.0758 2.3838 -0.9403 0.1480 3.1618 0.3729 0.3823 0.1555 1.4839 0.0395 1.1493 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 473: 92.1980 -5.8264 -0.0760 2.3836 -0.9402 0.1478 3.1602 0.3728 0.3820 0.1554 1.4839 0.0395 1.1489 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 474: 92.1976 -5.8256 -0.0762 2.3834 -0.9402 0.1475 3.1565 0.3727 0.3818 0.1554 1.4842 0.0395 1.1487 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 475: 92.1971 -5.8252 -0.0763 2.3832 -0.9402 0.1473 3.1543 0.3726 0.3816 0.1553 1.4845 0.0395 1.1487 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 476: 92.1965 -5.8250 -0.0765 2.3830 -0.9402 0.1469 3.1523 0.3725 0.3814 0.1552 1.4846 0.0395 1.1484 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 477: 92.1960 -5.8242 -0.0766 2.3827 -0.9402 0.1465 3.1483 0.3724 0.3811 0.1552 1.4849 0.0395 1.1483 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 478: 92.1955 -5.8236 -0.0767 2.3826 -0.9402 0.1463 3.1447 0.3722 0.3808 0.1553 1.4854 0.0395 1.1481 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 479: 92.1952 -5.8232 -0.0769 2.3824 -0.9401 0.1462 3.1421 0.3722 0.3805 0.1554 1.4857 0.0395 1.1478 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 480: 92.1948 -5.8235 -0.0770 2.3822 -0.9400 0.1461 3.1426 0.3721 0.3803 0.1554 1.4862 0.0395 1.1478 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 481: 92.1947 -5.8240 -0.0772 2.3820 -0.9399 0.1459 3.1455 0.3721 0.3801 0.1554 1.4868 0.0395 1.1483 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 482: 92.1948 -5.8244 -0.0774 2.3817 -0.9399 0.1456 3.1476 0.3720 0.3799 0.1553 1.4873 0.0395 1.1488 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 483: 92.1944 -5.8247 -0.0776 2.3815 -0.9397 0.1455 3.1487 0.3719 0.3797 0.1553 1.4876 0.0394 1.1494 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 484: 92.1941 -5.8249 -0.0778 2.3811 -0.9396 0.1454 3.1493 0.3719 0.3795 0.1554 1.4879 0.0394 1.1501 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 485: 92.1940 -5.8252 -0.0780 2.3809 -0.9396 0.1453 3.1501 0.3718 0.3793 0.1554 1.4881 0.0394 1.1503 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 486: 92.1936 -5.8249 -0.0781 2.3807 -0.9395 0.1453 3.1486 0.3717 0.3792 0.1554 1.4884 0.0394 1.1508 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 487: 92.1935 -5.8248 -0.0783 2.3804 -0.9394 0.1453 3.1485 0.3716 0.3791 0.1553 1.4887 0.0393 1.1507 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 488: 92.1932 -5.8246 -0.0785 2.3800 -0.9394 0.1454 3.1478 0.3715 0.3788 0.1552 1.4892 0.0393 1.1510 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 489: 92.1931 -5.8241 -0.0787 2.3796 -0.9394 0.1455 3.1468 0.3715 0.3787 0.1551 1.4895 0.0393 1.1514 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 490: 92.1934 -5.8242 -0.0790 2.3793 -0.9393 0.1456 3.1478 0.3715 0.3786 0.1551 1.4898 0.0393 1.1528 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 491: 92.1936 -5.8241 -0.0792 2.3788 -0.9392 0.1455 3.1472 0.3715 0.3785 0.1551 1.4900 0.0393 1.1533 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 492: 92.1940 -5.8234 -0.0794 2.3783 -0.9391 0.1455 3.1449 0.3714 0.3783 0.1551 1.4903 0.0392 1.1538 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 493: 92.1943 -5.8230 -0.0797 2.3779 -0.9390 0.1455 3.1426 0.3714 0.3783 0.1552 1.4907 0.0392 1.1541 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 494: 92.1946 -5.8226 -0.0799 2.3774 -0.9390 0.1458 3.1405 0.3713 0.3782 0.1551 1.4911 0.0392 1.1541 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 495: 92.1948 -5.8219 -0.0802 2.3770 -0.9391 0.1459 3.1366 0.3712 0.3782 0.1551 1.4916 0.0392 1.1543 0.0706</span> +<span class="r-out co"><span class="r-pr">#></span> 496: 92.1948 -5.8213 -0.0804 2.3766 -0.9392 0.1460 3.1331 0.3711 0.3781 0.1552 1.4920 0.0392 1.1556 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 497: 92.1949 -5.8213 -0.0806 2.3762 -0.9393 0.1462 3.1326 0.3711 0.3780 0.1553 1.4923 0.0391 1.1564 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 498: 92.1950 -5.8215 -0.0808 2.3758 -0.9394 0.1462 3.1331 0.3710 0.3779 0.1553 1.4926 0.0391 1.1568 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 499: 92.1953 -5.8219 -0.0810 2.3754 -0.9395 0.1461 3.1343 0.3709 0.3778 0.1554 1.4929 0.0391 1.1567 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 92.1957 -5.8232 -0.0812 2.3751 -0.9395 0.1459 3.1411 0.3709 0.3776 0.1554 1.4931 0.0391 1.1575 0.0705</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta |sigma_low_parent |rsd_high_parent |sigma_low_A1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................|rsd_high_A1 | o1 | o2 | o3 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o4 | o5 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 500.20030 | 1.000 | -1.000 | -0.9113 | -0.8944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8678 | -0.8916 | -0.8678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8916 | -0.8767 | -0.8743 | -0.8675 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8704 | -0.8704 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 500.2003 | 93.00 | -5.300 | -0.9400 | -0.1100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.200 | 0.03000 | 1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03000 | 0.7598 | 0.8758 | 1.214 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 | 1.071 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 500.2003</span> | 93.00 | 0.004992 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.200 | 0.03000 | 1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03000 | 0.7598 | 0.8758 | 1.214 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 | 1.071 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 48.88 | 2.383 | 0.1231 | 0.1986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1571 | -68.85 | -20.11 | 3.616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.292 | 0.6250 | 11.41 | -12.48 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.903 | -10.91 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2737.7532 | 0.4556 | -1.027 | -0.9127 | -0.8966 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.1009 | -0.6676 | -0.9080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8660 | -0.8837 | -1.001 | -0.7285 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7601 | -0.7489 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 2737.7532 | 42.37 | -5.327 | -0.9413 | -0.1122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.660 | 0.03336 | 1.176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03038 | 0.7545 | 0.7645 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.185 | 1.201 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2737.7532</span> | 42.37 | 0.004861 | 0.2806 | 0.8939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.957 | 1.660 | 0.03336 | 1.176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03038 | 0.7545 | 0.7645 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.185 | 1.201 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 513.07755 | 0.9456 | -1.003 | -0.9114 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7911 | -0.8692 | -0.8718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8890 | -0.8774 | -0.8871 | -0.8536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8594 | -0.8582 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 513.07755 | 87.94 | -5.303 | -0.9401 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.246 | 0.03034 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7593 | 0.8646 | 1.231 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.079 | 1.084 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 513.07755</span> | 87.94 | 0.004978 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.246 | 0.03034 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7593 | 0.8646 | 1.231 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.079 | 1.084 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 499.28604 | 0.9888 | -1.001 | -0.9113 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8520 | -0.8870 | -0.8686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8910 | -0.8769 | -0.8770 | -0.8646 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8682 | -0.8679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 499.28604 | 91.96 | -5.301 | -0.9400 | -0.1100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.209 | 0.03007 | 1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7597 | 0.8735 | 1.218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.070 | 1.074 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 499.28604</span> | 91.96 | 0.004989 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.209 | 0.03007 | 1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7597 | 0.8735 | 1.218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.070 | 1.074 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -111.5 | 2.236 | -0.2057 | 0.1035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1971 | -66.17 | -21.17 | 4.107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.586 | 1.583 | 8.991 | -11.70 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.625 | -10.49 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 497.76004 | 1.001 | -1.001 | -0.9113 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8366 | -0.8822 | -0.8695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8906 | -0.8771 | -0.8792 | -0.8619 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8660 | -0.8654 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 497.76004 | 93.05 | -5.301 | -0.9400 | -0.1101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.219 | 0.03014 | 1.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7595 | 0.8715 | 1.221 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.072 | 1.076 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 497.76004</span> | 93.05 | 0.004986 | 0.2809 | 0.8958 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.219 | 0.03014 | 1.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7595 | 0.8715 | 1.221 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.072 | 1.076 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 56.91 | 2.356 | 0.1468 | 0.2109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1761 | -64.61 | -18.67 | 3.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.680 | 1.108 | 8.338 | -11.70 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.518 | -10.47 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 496.73820 | 0.9899 | -1.002 | -0.9113 | -0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8205 | -0.8775 | -0.8703 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8902 | -0.8774 | -0.8813 | -0.8590 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8636 | -0.8628 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 496.7382 | 92.06 | -5.302 | -0.9400 | -0.1101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.228 | 0.03021 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03002 | 0.7593 | 0.8696 | 1.225 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.075 | 1.079 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.7382</span> | 92.06 | 0.004983 | 0.2809 | 0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.228 | 0.03021 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03002 | 0.7593 | 0.8696 | 1.225 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.075 | 1.079 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -94.52 | 2.222 | -0.1721 | 0.1131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1712 | -62.76 | -19.55 | 3.974 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.718 | 1.304 | 7.360 | -11.47 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.402 | -10.21 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 495.33979 | 1.001 | -1.002 | -0.9113 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8044 | -0.8726 | -0.8713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8897 | -0.8777 | -0.8834 | -0.8560 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8612 | -0.8602 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.33979 | 93.05 | -5.302 | -0.9400 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.238 | 0.03028 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7591 | 0.8679 | 1.228 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.077 | 1.082 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.33979</span> | 93.05 | 0.004981 | 0.2809 | 0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.238 | 0.03028 | 1.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7591 | 0.8679 | 1.228 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.077 | 1.082 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 56.11 | 2.327 | 0.1520 | 0.2091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1742 | -61.13 | -17.23 | 3.435 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.620 | 1.132 | 9.399 | -11.44 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.328 | -10.19 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 494.31617 | 0.9904 | -1.003 | -0.9113 | -0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7881 | -0.8680 | -0.8722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | -0.8780 | -0.8859 | -0.8530 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8587 | -0.8575 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.31617 | 92.11 | -5.303 | -0.9400 | -0.1102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.248 | 0.03035 | 1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7589 | 0.8657 | 1.232 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.085 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.31617</span> | 92.11 | 0.004977 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.248 | 0.03035 | 1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7589 | 0.8657 | 1.232 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.085 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -86.81 | 2.198 | -0.1566 | 0.1238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1638 | -59.37 | -18.02 | 4.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.591 | 1.325 | 8.479 | -11.19 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.201 | -9.937 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 493.00423 | 1.001 | -1.003 | -0.9113 | -0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.7718 | -0.8631 | -0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8888 | -0.8783 | -0.8883 | -0.8499 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8562 | -0.8548 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 493.00423 | 93.05 | -5.303 | -0.9400 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.258 | 0.03043 | 1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7586 | 0.8635 | 1.236 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.083 | 1.088 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.00423</span> | 93.05 | 0.004974 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.258 | 0.03043 | 1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7586 | 0.8635 | 1.236 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.083 | 1.088 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.84 | 2.286 | 0.1404 | 0.2142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1628 | -57.96 | -15.94 | 3.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.642 | 1.184 | 9.036 | -11.17 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.110 | -9.901 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 491.99601 | 0.9908 | -1.004 | -0.9114 | -0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7552 | -0.8585 | -0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8884 | -0.8786 | -0.8910 | -0.8467 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8536 | -0.8520 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.99601 | 92.15 | -5.304 | -0.9401 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.268 | 0.03050 | 1.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03005 | 0.7584 | 0.8612 | 1.239 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.085 | 1.091 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.99601</span> | 92.15 | 0.004971 | 0.2809 | 0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.268 | 0.03050 | 1.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03005 | 0.7584 | 0.8612 | 1.239 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.085 | 1.091 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -80.67 | 2.171 | -0.1367 | 0.1256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1610 | -56.13 | -16.61 | 4.047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.607 | 1.226 | 8.142 | -10.92 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.982 | -9.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 490.76421 | 1.000 | -1.005 | -0.9113 | -0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7388 | -0.8538 | -0.8754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8879 | -0.8790 | -0.8935 | -0.8435 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8510 | -0.8492 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.76421 | 93.04 | -5.305 | -0.9401 | -0.1104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.277 | 0.03057 | 1.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7581 | 0.8590 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.094 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.76421</span> | 93.04 | 0.004968 | 0.2809 | 0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.277 | 0.03057 | 1.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7581 | 0.8590 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.094 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.34 | 2.256 | 0.1715 | 0.2224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1653 | -54.87 | -14.72 | 3.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.777 | 1.023 | 8.651 | -10.90 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.887 | -9.594 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 489.76286 | 0.9913 | -1.005 | -0.9114 | -0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7220 | -0.8492 | -0.8764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8873 | -0.8793 | -0.8962 | -0.8402 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8483 | -0.8462 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 489.76286 | 92.19 | -5.305 | -0.9401 | -0.1104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.287 | 0.03063 | 1.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7579 | 0.8566 | 1.247 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 | 1.097 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.76286</span> | 92.19 | 0.004965 | 0.2809 | 0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.287 | 0.03063 | 1.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7579 | 0.8566 | 1.247 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 | 1.097 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -73.18 | 2.145 | -0.1190 | 0.1261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1580 | -53.08 | -15.27 | 4.015 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.639 | 1.110 | 7.813 | -10.65 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.743 | -9.338 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 488.61493 | 1.000 | -1.006 | -0.9114 | -0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7053 | -0.8446 | -0.8776 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8867 | -0.8796 | -0.8989 | -0.8368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8455 | -0.8433 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.61493 | 93.04 | -5.306 | -0.9401 | -0.1105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.297 | 0.03070 | 1.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03007 | 0.7577 | 0.8543 | 1.252 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.094 | 1.100 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.61493</span> | 93.04 | 0.004961 | 0.2809 | 0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.297 | 0.03070 | 1.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03007 | 0.7577 | 0.8543 | 1.252 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.094 | 1.100 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.41 | 2.230 | 0.1889 | 0.2376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1637 | -52.01 | -13.54 | 3.223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.937 | 0.8847 | 10.07 | -10.59 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.650 | -9.282 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 487.61806 | 0.9919 | -1.007 | -0.9114 | -0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6884 | -0.8402 | -0.8788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8861 | -0.8798 | -0.9022 | -0.8333 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8427 | -0.8402 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.61806 | 92.24 | -5.307 | -0.9401 | -0.1105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.308 | 0.03077 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03008 | 0.7575 | 0.8514 | 1.256 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.097 | 1.103 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.61806</span> | 92.24 | 0.004958 | 0.2809 | 0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.308 | 0.03077 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03008 | 0.7575 | 0.8514 | 1.256 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.097 | 1.103 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -64.97 | 2.116 | -0.09941 | 0.1372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1475 | -50.35 | -14.02 | 3.916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.790 | 0.8979 | 9.163 | -10.32 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.505 | -9.022 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 486.55968 | 1.001 | -1.008 | -0.9114 | -0.8950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6717 | -0.8358 | -0.8800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8854 | -0.8801 | -0.9058 | -0.8297 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8398 | -0.8372 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 486.55968 | 93.05 | -5.308 | -0.9401 | -0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.318 | 0.03084 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03009 | 0.7573 | 0.8482 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.100 | 1.107 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.55968</span> | 93.05 | 0.004954 | 0.2809 | 0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.318 | 0.03084 | 1.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03009 | 0.7573 | 0.8482 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.100 | 1.107 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.08 | 2.188 | 0.1916 | 0.2341 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1660 | -48.95 | -12.27 | 3.347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.726 | 0.9589 | 6.446 | -10.30 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.390 | -8.950 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 485.60262 | 0.9920 | -1.008 | -0.9115 | -0.8951 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6547 | -0.8316 | -0.8813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8847 | -0.8804 | -0.9083 | -0.8260 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8367 | -0.8340 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.60262 | 92.26 | -5.308 | -0.9402 | -0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.328 | 0.03090 | 1.192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03010 | 0.7571 | 0.8460 | 1.265 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.104 | 1.110 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.60262</span> | 92.26 | 0.004950 | 0.2809 | 0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.328 | 0.03090 | 1.192 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03010 | 0.7571 | 0.8460 | 1.265 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.104 | 1.110 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -62.47 | 2.078 | -0.09882 | 0.1294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1587 | -47.42 | -12.81 | 3.926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.683 | 0.9415 | 5.611 | -10.02 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.237 | -8.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 484.58535 | 1.000 | -1.009 | -0.9115 | -0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6375 | -0.8274 | -0.8829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8840 | -0.8807 | -0.9099 | -0.8222 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8336 | -0.8307 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.58535 | 93.02 | -5.309 | -0.9402 | -0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.338 | 0.03096 | 1.191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03011 | 0.7568 | 0.8446 | 1.269 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.114 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.58535</span> | 93.02 | 0.004946 | 0.2809 | 0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.338 | 0.03096 | 1.191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03011 | 0.7568 | 0.8446 | 1.269 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.114 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 50.15 | 2.155 | 0.1960 | 0.2225 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1509 | -46.14 | -11.19 | 3.405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.652 | 1.035 | 7.536 | -9.951 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.121 | -8.609 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 483.66860 | 0.9923 | -1.010 | -0.9115 | -0.8952 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6203 | -0.8235 | -0.8844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8833 | -0.8810 | -0.9123 | -0.8182 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8303 | -0.8273 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.6686 | 92.29 | -5.310 | -0.9402 | -0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.348 | 0.03102 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03012 | 0.7565 | 0.8425 | 1.274 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.117 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.6686</span> | 92.29 | 0.004942 | 0.2809 | 0.8951 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.348 | 0.03102 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03012 | 0.7565 | 0.8425 | 1.274 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.117 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -57.62 | 2.059 | -0.07549 | 0.1395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1501 | -44.74 | -11.66 | 3.913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.664 | 0.8845 | 6.781 | -9.703 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.961 | -8.325 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 482.71012 | 1.000 | -1.011 | -0.9115 | -0.8953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6032 | -0.8198 | -0.8861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8825 | -0.8814 | -0.9153 | -0.8141 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8270 | -0.8239 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.71012 | 93.02 | -5.311 | -0.9402 | -0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.359 | 0.03108 | 1.189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03014 | 0.7563 | 0.8399 | 1.279 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.114 | 1.121 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.71012</span> | 93.02 | 0.004937 | 0.2809 | 0.8950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.359 | 0.03108 | 1.189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03014 | 0.7563 | 0.8399 | 1.279 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.114 | 1.121 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.98 | 2.122 | 0.2043 | 0.2315 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1449 | -43.47 | -10.15 | 3.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.703 | 0.9582 | 7.160 | -9.600 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.838 | -8.245 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 481.83107 | 0.9926 | -1.012 | -0.9116 | -0.8954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5860 | -0.8164 | -0.8879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8817 | -0.8818 | -0.9184 | -0.8098 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8235 | -0.8203 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.83107 | 92.31 | -5.312 | -0.9403 | -0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.369 | 0.03113 | 1.188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03015 | 0.7560 | 0.8372 | 1.284 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.118 | 1.125 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.83107</span> | 92.31 | 0.004932 | 0.2808 | 0.8949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.369 | 0.03113 | 1.188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03015 | 0.7560 | 0.8372 | 1.284 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.118 | 1.125 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -54.27 | 2.027 | -0.06740 | 0.1414 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1465 | -41.84 | -10.48 | 3.798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.730 | 0.8044 | 6.401 | -9.335 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.662 | -7.960 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 480.92878 | 1.000 | -1.013 | -0.9117 | -0.8955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5689 | -0.8133 | -0.8899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8807 | -0.8821 | -0.9215 | -0.8053 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8199 | -0.8166 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.92878 | 93.01 | -5.313 | -0.9403 | -0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.379 | 0.03117 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03016 | 0.7557 | 0.8345 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.122 | 1.129 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.92878</span> | 93.01 | 0.004927 | 0.2808 | 0.8948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.379 | 0.03117 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03016 | 0.7557 | 0.8345 | 1.290 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.122 | 1.129 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 47.18 | 2.077 | 0.1996 | 0.2200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1318 | -41.07 | -9.197 | 3.259 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.748 | 0.9101 | 6.743 | -9.229 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.511 | -7.855 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 480.07574 | 0.9930 | -1.014 | -0.9117 | -0.8956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5517 | -0.8106 | -0.8919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8795 | -0.8825 | -0.9247 | -0.8007 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8161 | -0.8129 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.07574 | 92.35 | -5.314 | -0.9404 | -0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.390 | 0.03121 | 1.186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03018 | 0.7555 | 0.8317 | 1.295 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.126 | 1.133 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.07574</span> | 92.35 | 0.004921 | 0.2808 | 0.8947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.390 | 0.03121 | 1.186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03018 | 0.7555 | 0.8317 | 1.295 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.126 | 1.133 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.22 | 1.995 | -0.04658 | 0.1415 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1316 | -39.56 | -9.522 | 3.639 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.878 | 0.6154 | 4.556 | -8.937 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.320 | -7.563 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 479.25211 | 1.000 | -1.015 | -0.9118 | -0.8957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.5343 | -0.8082 | -0.8940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8781 | -0.8826 | -0.9261 | -0.7958 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8122 | -0.8090 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.25211 | 93.02 | -5.315 | -0.9405 | -0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.400 | 0.03125 | 1.184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03020 | 0.7553 | 0.8305 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.130 | 1.137 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.25211</span> | 93.02 | 0.004915 | 0.2808 | 0.8946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.400 | 0.03125 | 1.184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03020 | 0.7553 | 0.8305 | 1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.130 | 1.137 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.39 | 2.048 | 0.2189 | 0.2175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1393 | -38.80 | -8.286 | 3.169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.757 | 0.9021 | 6.456 | -8.802 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.165 | -7.452 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 478.42395 | 0.9935 | -1.017 | -0.9119 | -0.8959 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.5169 | -0.8064 | -0.8963 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8766 | -0.8829 | -0.9277 | -0.7908 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8081 | -0.8051 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.42395 | 92.40 | -5.317 | -0.9406 | -0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.411 | 0.03128 | 1.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03022 | 0.7552 | 0.8290 | 1.307 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.134 | 1.141 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.42395</span> | 92.40 | 0.004909 | 0.2808 | 0.8945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.411 | 0.03128 | 1.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03022 | 0.7552 | 0.8290 | 1.307 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.134 | 1.141 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -41.65 | 1.977 | -0.02866 | 0.1453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1180 | -37.67 | -8.677 | 3.579 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.774 | 0.6894 | 5.855 | -8.506 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.962 | -7.153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 477.65816 | 1.000 | -1.018 | -0.9120 | -0.8960 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4997 | -0.8051 | -0.8988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8750 | -0.8832 | -0.9313 | -0.7859 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8042 | -0.8013 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.65816 | 93.02 | -5.318 | -0.9406 | -0.1116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.421 | 0.03130 | 1.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03025 | 0.7549 | 0.8259 | 1.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.138 | 1.145 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.65816</span> | 93.02 | 0.004901 | 0.2808 | 0.8944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.421 | 0.03130 | 1.181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03025 | 0.7549 | 0.8259 | 1.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.138 | 1.145 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 47.50 | 2.013 | 0.2278 | 0.2145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1415 | -36.68 | -7.460 | 3.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.807 | 0.8669 | 6.124 | -8.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.814 | -7.074 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 476.87668 | 0.9936 | -1.020 | -0.9121 | -0.8962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4825 | -0.8047 | -0.9014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8732 | -0.8836 | -0.9351 | -0.7808 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8001 | -0.7975 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.87668 | 92.41 | -5.320 | -0.9408 | -0.1117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.431 | 0.03130 | 1.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03028 | 0.7546 | 0.8226 | 1.319 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.143 | 1.149 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.87668</span> | 92.41 | 0.004893 | 0.2807 | 0.8943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.431 | 0.03130 | 1.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03028 | 0.7546 | 0.8226 | 1.319 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.143 | 1.149 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -40.64 | 1.935 | -0.02164 | 0.1511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1127 | -35.59 | -7.858 | 3.450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.805 | 0.6731 | 3.945 | -8.048 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.589 | -6.756 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 476.16299 | 1.000 | -1.022 | -0.9123 | -0.8963 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4651 | -0.8047 | -0.9041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8711 | -0.8840 | -0.9355 | -0.7757 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7959 | -0.7936 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.16299 | 93.01 | -5.322 | -0.9409 | -0.1119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.442 | 0.03130 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03031 | 0.7543 | 0.8222 | 1.326 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.147 | 1.153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.16299</span> | 93.01 | 0.004885 | 0.2807 | 0.8941 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.442 | 0.03130 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03031 | 0.7543 | 0.8222 | 1.326 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.147 | 1.153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 44.38 | 1.982 | 0.2331 | 0.2213 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1467 | -34.64 | -6.709 | 2.894 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.888 | 0.7760 | 4.358 | -7.901 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.419 | -6.620 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 475.47434 | 0.9938 | -1.024 | -0.9125 | -0.8966 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4477 | -0.8058 | -0.9069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8685 | -0.8844 | -0.9328 | -0.7706 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7919 | -0.7898 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.47434 | 92.43 | -5.324 | -0.9411 | -0.1122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.452 | 0.03129 | 1.177 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03035 | 0.7540 | 0.8246 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.151 | 1.157 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.47434</span> | 92.43 | 0.004875 | 0.2807 | 0.8939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.452 | 0.03129 | 1.177 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03035 | 0.7540 | 0.8246 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.151 | 1.157 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -38.01 | 1.932 | -0.02542 | 0.1483 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1147 | -33.71 | -7.114 | 3.216 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.879 | 0.6267 | 4.067 | -7.573 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.213 | -6.338 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 474.82575 | 0.9998 | -1.026 | -0.9126 | -0.8968 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4303 | -0.8075 | -0.9096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8656 | -0.8846 | -0.9310 | -0.7657 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7878 | -0.7862 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.82575 | 92.98 | -5.326 | -0.9413 | -0.1124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.462 | 0.03126 | 1.175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03039 | 0.7538 | 0.8261 | 1.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.156 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.82575</span> | 92.98 | 0.004864 | 0.2806 | 0.8937 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.462 | 0.03126 | 1.175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03039 | 0.7538 | 0.8261 | 1.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.156 | 1.161 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.83 | 1.980 | 0.2123 | 0.2125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1324 | -32.65 | -6.032 | 2.979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.922 | 0.7692 | 4.596 | -7.426 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.058 | -6.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 474.18202 | 0.9939 | -1.028 | -0.9128 | -0.8971 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4131 | -0.8106 | -0.9130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8620 | -0.8851 | -0.9307 | -0.7608 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7838 | -0.7828 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.18202 | 92.44 | -5.328 | -0.9414 | -0.1127 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.473 | 0.03121 | 1.173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03044 | 0.7535 | 0.8264 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.160 | 1.165 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.18202</span> | 92.44 | 0.004852 | 0.2806 | 0.8935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.473 | 0.03121 | 1.173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03044 | 0.7535 | 0.8264 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.160 | 1.165 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -37.33 | 1.920 | -0.03157 | 0.1462 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1145 | -31.92 | -6.433 | 3.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.919 | 0.6114 | 5.640 | -7.155 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.876 | -5.958 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 473.55376 | 0.9995 | -1.031 | -0.9130 | -0.8973 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.3971 | -0.8148 | -0.9162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8581 | -0.8855 | -0.9368 | -0.7563 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7800 | -0.7797 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.55376 | 92.95 | -5.331 | -0.9416 | -0.1129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.482 | 0.03115 | 1.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03050 | 0.7531 | 0.8211 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.164 | 1.168 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.55376</span> | 92.95 | 0.004838 | 0.2806 | 0.8932 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.482 | 0.03115 | 1.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03050 | 0.7531 | 0.8211 | 1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.164 | 1.168 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 472.90182 | 0.9995 | -1.035 | -0.9132 | -0.8977 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8453 | -0.3799 | -0.8225 | -0.9204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8527 | -0.8861 | -0.9447 | -0.7510 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7757 | -0.7763 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.90182 | 92.96 | -5.335 | -0.9418 | -0.1133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.493 | 0.03104 | 1.168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03058 | 0.7527 | 0.8141 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.169 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.90182</span> | 92.96 | 0.004819 | 0.2805 | 0.8929 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.975 | 1.493 | 0.03104 | 1.168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03058 | 0.7527 | 0.8141 | 1.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.169 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 469.90339 | 0.9997 | -1.054 | -0.9142 | -0.8996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8452 | -0.2944 | -0.8611 | -0.9412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8255 | -0.8889 | -0.9843 | -0.7249 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7539 | -0.7597 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.90339 | 92.98 | -5.354 | -0.9427 | -0.1152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.544 | 0.03046 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03099 | 0.7505 | 0.7794 | 1.387 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.192 | 1.190 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.90339</span> | 92.98 | 0.004727 | 0.2803 | 0.8912 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.976 | 1.544 | 0.03046 | 1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03099 | 0.7505 | 0.7794 | 1.387 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.192 | 1.190 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 461.71523 | 1.001 | -1.134 | -0.9184 | -0.9072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8447 | 0.05742 | -1.020 | -1.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7136 | -0.9005 | -1.147 | -0.6175 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6642 | -0.6913 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 461.71523 | 93.05 | -5.434 | -0.9467 | -0.1228 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.301 | 1.755 | 0.02808 | 1.105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03267 | 0.7417 | 0.6368 | 1.518 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.288 | 1.263 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 461.71523</span> | 93.05 | 0.004366 | 0.2795 | 0.8844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.981 | 1.755 | 0.02808 | 1.105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03267 | 0.7417 | 0.6368 | 1.518 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.288 | 1.263 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.20 | 1.045 | 1.020 | 0.3495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7923 | -15.00 | -0.3969 | -1.315 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.031 | 0.2676 | -6.780 | -1.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.09081 | -1.463 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 459.94653 | 1.009 | -1.206 | -0.9768 | -0.9283 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8884 | 0.4547 | -1.238 | -0.9419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5030 | -0.9080 | -0.7892 | -0.6450 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7313 | -0.6959 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 459.94653 | 93.85 | -5.506 | -1.002 | -0.1439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.257 | 1.993 | 0.02480 | 1.155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03583 | 0.7361 | 0.9504 | 1.484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.216 | 1.258 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 459.94653</span> | 93.85 | 0.004064 | 0.2686 | 0.8660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.554 | 1.993 | 0.02480 | 1.155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03583 | 0.7361 | 0.9504 | 1.484 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.216 | 1.258 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 117.0 | 1.389 | -1.721 | -0.1200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.004314 | -5.763 | 2.093 | 3.426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.378 | 2.600 | 15.14 | -1.236 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.018 | -1.529 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 458.11528 | 1.003 | -1.307 | -0.9477 | -0.9422 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9430 | 0.6906 | -1.630 | -0.8850 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1864 | -1.043 | -0.8947 | -0.8359 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7822 | -0.7759 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 458.11528 | 93.30 | -5.607 | -0.9742 | -0.1578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.202 | 2.135 | 0.01893 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04058 | 0.6334 | 0.8579 | 1.253 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.162 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11528</span> | 93.30 | 0.003671 | 0.2740 | 0.8540 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.046 | 2.135 | 0.01893 | 1.190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04058 | 0.6334 | 0.8579 | 1.253 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.162 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.502 | 0.8367 | -0.1865 | -0.1361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6555 | -2.945 | 1.425 | 8.523 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6882 | -2.700 | 7.982 | -9.961 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.514 | -5.474 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 454.42202 | 1.008 | -1.411 | -0.9501 | -0.9563 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9900 | 0.8215 | -2.099 | -1.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1520 | -1.049 | -0.9274 | -0.7533 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7158 | -0.7241 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 454.42202 | 93.74 | -5.711 | -0.9765 | -0.1719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.155 | 2.214 | 0.01188 | 1.102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04565 | 0.6287 | 0.8293 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.233 | 1.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.42202</span> | 93.74 | 0.003311 | 0.2736 | 0.8421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.631 | 2.214 | 0.01188 | 1.102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04565 | 0.6287 | 0.8293 | 1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.233 | 1.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 451.48622 | 1.000 | -1.659 | -0.9551 | -0.9914 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.111 | 1.029 | -2.892 | -1.353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9897 | -1.076 | -0.9627 | -0.6147 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5957 | -0.6379 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 451.48622 | 93.01 | -5.959 | -0.9812 | -0.2070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.035 | 2.338 | 5.960e-07 | 0.9088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05822 | 0.6083 | 0.7984 | 1.521 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.361 | 1.320 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 451.48622</span> | 93.01 | 0.002583 | 0.2727 | 0.8130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.651 | 2.338 | 5.960e-07 | 0.9088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05822 | 0.6083 | 0.7984 | 1.521 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.361 | 1.320 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -68.34 | 0.03355 | 0.09905 | -1.306 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.058 | -1.204 | -0.09883 | -1.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.726 | -4.145 | 7.646 | -0.5743 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.003 | 2.613 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 453.25472 | 1.003 | -2.027 | -1.069 | -0.8933 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6960 | 1.084 | -2.892 | -1.695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.689 | -0.4882 | -1.206 | -0.2814 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7545 | -0.8496 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 453.25472 | 93.31 | -6.327 | -1.089 | -0.1089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.449 | 2.371 | 5.960e-07 | 0.7037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08370 | 1.055 | 0.5857 | 1.926 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.191 | 1.093 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 453.25472</span> | 93.31 | 0.001787 | 0.2519 | 0.8968 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.58 | 2.371 | 5.960e-07 | 0.7037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08370 | 1.055 | 0.5857 | 1.926 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.191 | 1.093 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 449.59369 | 1.000 | -1.818 | -1.010 | -0.9508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.052 | -2.892 | -1.498 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8175 | -1.073 | -0.4671 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6691 | -0.7270 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 449.59369 | 93.04 | -6.118 | -1.033 | -0.1664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.960e-07 | 0.8216 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8048 | 0.7021 | 1.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.282 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.59369</span> | 93.04 | 0.002202 | 0.2625 | 0.8467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.960e-07 | 0.8216 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8048 | 0.7021 | 1.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.282 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -128.1 | 0.1096 | -3.510 | -0.1773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1823 | -1.358 | -0.002263 | 1.313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.294 | 5.530 | 5.100 | 4.831 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.292 | -3.851 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 472.13387 | 1.020 | -1.985 | -0.7592 | -0.7822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2976 | 1.062 | -2.892 | -1.866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.141 | -0.7519 | -1.136 | -0.6405 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7706 | -0.2153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.13387 | 94.83 | -6.285 | -0.7970 | 0.002176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.848 | 2.358 | 5.960e-07 | 0.6009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09049 | 0.8547 | 0.6467 | 1.490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.174 | 1.773 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.13387</span> | 94.83 | 0.001864 | 0.3107 | 1.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 17.25 | 2.358 | 5.960e-07 | 0.6009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09049 | 0.8547 | 0.6467 | 1.490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.174 | 1.773 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 454.13083 | 1.030 | -1.841 | -0.9756 | -0.9280 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | 1.054 | -2.892 | -1.548 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.921 | -0.8098 | -1.082 | -0.4916 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6825 | -0.6571 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 454.13083 | 95.82 | -6.141 | -1.000 | -0.1436 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.295 | 2.353 | 5.960e-07 | 0.7917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07219 | 0.8106 | 0.6936 | 1.671 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.299 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.13083</span> | 95.82 | 0.002153 | 0.2688 | 0.8663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.927 | 2.353 | 5.960e-07 | 0.7917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07219 | 0.8106 | 0.6936 | 1.671 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.299 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 454.81886 | 1.032 | -1.823 | -1.002 | -0.9459 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9179 | 1.053 | -2.892 | -1.509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.771 | -0.8169 | -1.076 | -0.4733 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6717 | -0.7113 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 454.81886 | 95.94 | -6.123 | -1.025 | -0.1614 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.227 | 2.352 | 5.960e-07 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06994 | 0.8052 | 0.6994 | 1.693 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.280 | 1.241 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.81886</span> | 95.94 | 0.002192 | 0.2640 | 0.8509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.277 | 2.352 | 5.960e-07 | 0.8150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06994 | 0.8052 | 0.6994 | 1.693 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.280 | 1.241 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 449.57011 | 1.014 | -1.818 | -1.010 | -0.9508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.053 | -2.892 | -1.499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8181 | -1.073 | -0.4676 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6690 | -0.7267 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 449.57011 | 94.27 | -6.118 | -1.033 | -0.1664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.995e-07 | 0.8215 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8044 | 0.7016 | 1.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.57011</span> | 94.27 | 0.002202 | 0.2626 | 0.8467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.995e-07 | 0.8215 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8044 | 0.7016 | 1.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 126.9 | 0.1582 | -2.201 | 0.05331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4695 | -0.6265 | 0.01503 | 0.4241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.337 | 5.854 | 6.688 | 4.536 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.410 | -4.016 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 449.14922 | 1.007 | -1.818 | -1.010 | -0.9508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.053 | -2.892 | -1.499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8183 | -1.074 | -0.4678 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6689 | -0.7265 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 449.14922 | 93.66 | -6.118 | -1.033 | -0.1664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.960e-07 | 0.8215 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8042 | 0.7014 | 1.699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.14922</span> | 93.66 | 0.002202 | 0.2626 | 0.8467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.960e-07 | 0.8215 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8042 | 0.7014 | 1.699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4066 | 0.1367 | -2.828 | -0.06013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1445 | -0.8286 | 0.01677 | 0.9213 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.224 | 4.943 | 4.017 | 5.223 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.311 | -3.922 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 449.08136 | 1.007 | -1.818 | -1.008 | -0.9507 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9365 | 1.053 | -2.892 | -1.499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.731 | -0.8217 | -1.076 | -0.4714 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6680 | -0.7238 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 449.08136 | 93.68 | -6.118 | -1.031 | -0.1663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.353 | 5.960e-07 | 0.8212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06934 | 0.8016 | 0.6990 | 1.695 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.284 | 1.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.08136</span> | 93.68 | 0.002202 | 0.2629 | 0.8468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.353 | 5.960e-07 | 0.8212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06934 | 0.8016 | 0.6990 | 1.695 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.284 | 1.228 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 448.89872 | 1.008 | -1.819 | -1.002 | -0.9506 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9368 | 1.055 | -2.892 | -1.501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.734 | -0.8317 | -1.084 | -0.4820 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6654 | -0.7159 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 448.89872 | 93.76 | -6.119 | -1.025 | -0.1662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.354 | 5.960e-07 | 0.8200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06938 | 0.7940 | 0.6918 | 1.682 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.286 | 1.237 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.89872</span> | 93.76 | 0.002202 | 0.2640 | 0.8469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.102 | 2.354 | 5.960e-07 | 0.8200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06938 | 0.7940 | 0.6918 | 1.682 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.286 | 1.237 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 448.46351 | 1.011 | -1.820 | -0.9792 | -0.9501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9380 | 1.062 | -2.892 | -1.509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.744 | -0.8718 | -1.117 | -0.5244 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6547 | -0.6840 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 448.46351 | 94.07 | -6.120 | -1.004 | -0.1657 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.207 | 2.358 | 5.960e-07 | 0.8155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06953 | 0.7635 | 0.6633 | 1.631 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 | 1.271 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.46351</span> | 94.07 | 0.002199 | 0.2682 | 0.8473 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.092 | 2.358 | 5.960e-07 | 0.8155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06953 | 0.7635 | 0.6633 | 1.631 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 | 1.271 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 75.37 | 0.2597 | -0.1569 | 0.03608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3501 | -0.3601 | -0.01324 | 0.5025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.327 | 4.308 | 0.9122 | 2.456 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5631 | -1.887 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 448.12149 | 1.008 | -1.833 | -0.9950 | -0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8937 | 1.062 | -2.892 | -1.543 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.827 | -0.8899 | -1.115 | -0.5324 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6574 | -0.6703 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 448.12149 | 93.73 | -6.133 | -1.019 | -0.1534 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.252 | 2.358 | 5.960e-07 | 0.7948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07077 | 0.7498 | 0.6653 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.295 | 1.285 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.12149</span> | 93.73 | 0.002169 | 0.2653 | 0.8578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.504 | 2.358 | 5.960e-07 | 0.7948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07077 | 0.7498 | 0.6653 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.295 | 1.285 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.78 | 0.2222 | -1.381 | 0.2569 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.259 | -0.5740 | -0.02850 | 0.1620 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.241 | 3.503 | 0.9893 | 2.205 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7124 | -1.054 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 447.94443 | 1.007 | -1.844 | -0.9902 | -0.9390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9059 | 1.062 | -2.881 | -1.561 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.911 | -0.9357 | -1.119 | -0.5167 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6474 | -0.7008 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.94443 | 93.62 | -6.144 | -1.014 | -0.1546 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.239 | 2.358 | 0.0001615 | 0.7838 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07204 | 0.7150 | 0.6617 | 1.640 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.306 | 1.253 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.94443</span> | 93.62 | 0.002146 | 0.2662 | 0.8567 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.388 | 2.358 | 0.0001615 | 0.7838 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07204 | 0.7150 | 0.6617 | 1.640 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.306 | 1.253 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.879 | 0.2071 | -1.215 | 0.2527 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8228 | -0.5096 | -0.06036 | 0.4983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.183 | 1.766 | 2.266 | 2.617 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3179 | -2.389 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 447.77390 | 1.007 | -1.858 | -1.003 | -0.9470 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9285 | 1.056 | -2.855 | -1.583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.006 | -0.9406 | -1.128 | -0.5198 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6539 | -0.6964 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.7739 | 93.69 | -6.158 | -1.026 | -0.1626 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 2.354 | 0.0005494 | 0.7710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07347 | 0.7113 | 0.6533 | 1.636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.299 | 1.257 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.7739</span> | 93.69 | 0.002117 | 0.2639 | 0.8500 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.179 | 2.354 | 0.0005494 | 0.7710 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07347 | 0.7113 | 0.6533 | 1.636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.299 | 1.257 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 447.56301 | 1.006 | -1.897 | -1.041 | -0.9708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9958 | 1.039 | -2.777 | -1.647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | -0.9540 | -1.156 | -0.5273 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6737 | -0.6848 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.56301 | 93.51 | -6.197 | -1.061 | -0.1864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.150 | 2.344 | 0.001717 | 0.7326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07774 | 0.7011 | 0.6293 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.278 | 1.270 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.56301</span> | 93.51 | 0.002035 | 0.2570 | 0.8300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.581 | 2.344 | 0.001717 | 0.7326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07774 | 0.7011 | 0.6293 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.278 | 1.270 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.60 | 0.2182 | -4.075 | -0.4855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.237 | -0.6626 | -0.1062 | 0.6612 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | 1.074 | 1.318 | 2.279 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.614 | -1.745 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 447.16930 | 1.007 | -1.971 | -0.9627 | -0.9652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9709 | 1.044 | -2.781 | -1.732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.691 | -0.9472 | -1.156 | -0.5162 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6828 | -0.6632 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.1693 | 93.67 | -6.271 | -0.9883 | -0.1807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.174 | 2.347 | 0.001652 | 0.6812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08374 | 0.7063 | 0.6288 | 1.641 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.1693</span> | 93.67 | 0.001890 | 0.2713 | 0.8346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.798 | 2.347 | 0.001652 | 0.6812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08374 | 0.7063 | 0.6288 | 1.641 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.693 | 0.1048 | 0.8560 | -0.3278 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6115 | -0.5188 | -0.09596 | 0.9789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.02585 | 1.094 | 1.548 | 2.318 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.079 | -0.9259 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 447.68852 | 1.013 | -2.042 | -1.008 | -0.9421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9288 | 1.034 | -2.709 | -1.852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.037 | -0.9368 | -1.153 | -0.6162 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5399 | -0.6984 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.68852 | 94.21 | -6.342 | -1.031 | -0.1577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 2.341 | 0.002735 | 0.6094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08893 | 0.7142 | 0.6313 | 1.519 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.420 | 1.255 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.68852</span> | 94.21 | 0.001761 | 0.2629 | 0.8541 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.176 | 2.341 | 0.002735 | 0.6094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08893 | 0.7142 | 0.6313 | 1.519 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.420 | 1.255 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 447.15405 | 1.011 | -1.991 | -0.9760 | -0.9584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9586 | 1.042 | -2.761 | -1.767 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.789 | -0.9450 | -1.157 | -0.5460 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6410 | -0.6726 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.15405 | 94.04 | -6.291 | -1.001 | -0.1740 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.187 | 2.346 | 0.001959 | 0.6605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08521 | 0.7080 | 0.6287 | 1.605 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.312 | 1.283 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.15405</span> | 94.04 | 0.001852 | 0.2688 | 0.8403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.906 | 2.346 | 0.001959 | 0.6605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08521 | 0.7080 | 0.6287 | 1.605 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.312 | 1.283 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 53.59 | 0.07914 | 0.2662 | -0.1234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1097 | -0.6518 | -0.06086 | 0.6193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05679 | 1.445 | 0.6511 | 1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1794 | -1.326 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 447.09915 | 1.005 | -2.002 | -0.9768 | -0.9545 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9567 | 1.042 | -2.752 | -1.789 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.838 | -0.9392 | -1.155 | -0.5617 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6261 | -0.6787 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.09915 | 93.47 | -6.302 | -1.002 | -0.1701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.189 | 2.346 | 0.002096 | 0.6471 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08594 | 0.7123 | 0.6298 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.328 | 1.276 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.09915</span> | 93.47 | 0.001833 | 0.2686 | 0.8436 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.923 | 2.346 | 0.002096 | 0.6471 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08594 | 0.7123 | 0.6298 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.328 | 1.276 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.97 | 0.05091 | -0.1219 | -0.09607 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3249 | -0.8735 | -0.1278 | 0.5888 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06635 | 1.636 | -1.923 | 0.5172 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.5270 | -1.419 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 447.01951 | 1.007 | -2.009 | -0.9874 | -0.9450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9329 | 1.053 | -2.780 | -1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.841 | -0.9693 | -1.155 | -0.5556 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6514 | -0.6721 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.01951 | 93.64 | -6.309 | -1.012 | -0.1606 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.212 | 2.352 | 0.001680 | 0.6361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08598 | 0.6895 | 0.6300 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.301 | 1.283 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.01951</span> | 93.64 | 0.001820 | 0.2667 | 0.8517 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.138 | 2.352 | 0.001680 | 0.6361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08598 | 0.6895 | 0.6300 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.301 | 1.283 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.500 | 0.04518 | -0.6412 | 0.1616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3106 | -0.6054 | -0.07873 | -0.1077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1002 | 0.2460 | 1.553 | 0.4490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8245 | -1.132 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 447.04861 | 1.009 | -2.019 | -0.9927 | -0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9252 | 1.054 | -2.796 | -1.779 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.878 | -0.9737 | -1.157 | -0.5487 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6291 | -0.6521 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.04861 | 93.85 | -6.319 | -1.017 | -0.1632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.220 | 2.353 | 0.001429 | 0.6532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08654 | 0.6862 | 0.6280 | 1.601 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.325 | 1.305 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.04861</span> | 93.85 | 0.001802 | 0.2657 | 0.8494 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.209 | 2.353 | 0.001429 | 0.6532 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08654 | 0.6862 | 0.6280 | 1.601 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.325 | 1.305 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 447.01937 | 1.009 | -2.012 | -0.9891 | -0.9459 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9304 | 1.053 | -2.785 | -1.798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.853 | -0.9708 | -1.156 | -0.5534 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6439 | -0.6653 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.01937 | 93.80 | -6.312 | -1.013 | -0.1615 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.215 | 2.353 | 0.001597 | 0.6418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08617 | 0.6884 | 0.6292 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.309 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.01937</span> | 93.80 | 0.001814 | 0.2664 | 0.8509 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.161 | 2.353 | 0.001597 | 0.6418 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08617 | 0.6884 | 0.6292 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.309 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.62 | 0.04451 | -0.6370 | 0.1658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4720 | -0.4967 | -0.06076 | 0.2478 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07878 | 0.2929 | 0.7908 | 0.7364 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2169 | -0.8458 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 447.00331 | 1.007 | -2.016 | -0.9874 | -0.9487 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9321 | 1.057 | -2.790 | -1.800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.856 | -0.9696 | -1.156 | -0.5575 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6423 | -0.6633 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 447.00331 | 93.68 | -6.316 | -1.012 | -0.1643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.213 | 2.355 | 0.001526 | 0.6406 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08622 | 0.6893 | 0.6295 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.00331</span> | 93.68 | 0.001807 | 0.2667 | 0.8485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.146 | 2.355 | 0.001526 | 0.6406 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08622 | 0.6893 | 0.6295 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.749 | 0.03581 | -0.6032 | 0.06997 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3775 | -0.4012 | -0.08782 | 0.2553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.001918 | 0.1783 | 1.513 | 0.3567 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3333 | -0.7379 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 446.99944 | 1.008 | -2.018 | -0.9851 | -0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9359 | 1.058 | -2.787 | -1.806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.859 | -0.9671 | -1.156 | -0.5614 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6427 | -0.6650 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 446.99944 | 93.70 | -6.318 | -1.009 | -0.1632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.355 | 0.001564 | 0.6369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08626 | 0.6911 | 0.6291 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99944</span> | 93.70 | 0.001804 | 0.2671 | 0.8494 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.111 | 2.355 | 0.001564 | 0.6369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08626 | 0.6911 | 0.6291 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.474 | 0.03546 | -0.4554 | 0.1057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2777 | -0.4692 | -0.06549 | 0.06429 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09650 | 0.2331 | 0.6150 | 0.1626 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3753 | -0.8072 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 446.99641 | 1.007 | -2.020 | -0.9846 | -0.9460 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9366 | 1.059 | -2.790 | -1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.868 | -0.9676 | -1.156 | -0.5621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6420 | -0.6633 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 446.99641 | 93.67 | -6.320 | -1.009 | -0.1616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.356 | 0.001530 | 0.6356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99641</span> | 93.67 | 0.001800 | 0.2672 | 0.8508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.356 | 0.001530 | 0.6356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.070 | 0.03317 | -0.4443 | 0.1488 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2478 | -0.4968 | -0.07674 | 0.09423 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05318 | 0.2365 | 0.6058 | 0.5619 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3013 | -0.7224 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 446.99641 | 1.007 | -2.020 | -0.9846 | -0.9460 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9366 | 1.059 | -2.790 | -1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.868 | -0.9676 | -1.156 | -0.5621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6420 | -0.6633 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 446.99641 | 93.67 | -6.320 | -1.009 | -0.1616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.356 | 0.001530 | 0.6356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99641</span> | 93.67 | 0.001800 | 0.2672 | 0.8508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.356 | 0.001530 | 0.6356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> +<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> 1: 90.7519 -4.8586 -1.7674 -3.5599 -2.0059 0.5800 4.8899 1.4250 1.1400 2.6923 0.4845 0.4370 10.2815 0.0004 9.0437 0.4047</span> +<span class="r-out co"><span class="r-pr">#></span> 2: 9.0763e+01 -5.2004e+00 -1.9605e+00 -4.2009e+00 -1.8767e+00 2.0341e-01 4.6454e+00 1.3537e+00 1.0830e+00 2.7771e+00 4.6027e-01 5.1181e-01 6.3469e+00 4.0033e-04 6.8216e+00 9.0448e-05</span> +<span class="r-out co"><span class="r-pr">#></span> 3: 9.0656e+01 -5.4820e+00 -2.0937e+00 -4.0962e+00 -1.5381e+00 -1.7136e-02 4.4131e+00 1.2861e+00 1.0288e+00 3.5620e+00 4.3726e-01 6.1217e-01 4.8763e+00 4.1436e-05 5.4967e+00 1.0148e-05</span> +<span class="r-out co"><span class="r-pr">#></span> 4: 9.0543e+01 -5.7744e+00 -2.1074e+00 -4.0393e+00 -1.3603e+00 -2.3531e-01 5.0162e+00 1.2218e+00 1.0041e+00 3.3839e+00 4.1540e-01 5.8157e-01 4.1029e+00 2.1466e-04 4.2869e+00 1.9419e-06</span> +<span class="r-out co"><span class="r-pr">#></span> 5: 91.1621 -6.0534 -2.0430 -4.0508 -1.2523 -0.2043 6.1015 1.1715 1.1998 3.2147 0.3946 0.5525 3.5979 0.0187 3.8221 0.0271</span> +<span class="r-out co"><span class="r-pr">#></span> 6: 91.1179 -5.9892 -2.0082 -4.1363 -1.1428 -0.1930 5.7964 1.1960 1.2360 3.4525 0.3749 0.5293 3.3091 0.0209 3.6230 0.0284</span> +<span class="r-out co"><span class="r-pr">#></span> 7: 91.6680 -5.9609 -2.0492 -4.1163 -1.0919 -0.1505 5.6134 1.6750 1.3055 3.2799 0.3631 0.5028 3.2412 0.0254 3.5108 0.0371</span> +<span class="r-out co"><span class="r-pr">#></span> 8: 91.6903 -5.9346 -2.0630 -4.0790 -1.1130 -0.0963 5.3327 2.2525 1.3524 3.1159 0.3449 0.4777 2.6165 0.0445 2.8556 0.0576</span> +<span class="r-out co"><span class="r-pr">#></span> 9: 92.2564 -5.7600 -2.0460 -4.1144 -1.0635 -0.0594 5.9616 2.1399 1.2848 2.9601 0.3277 0.4538 2.3593 0.0295 2.5704 0.0491</span> +<span class="r-out co"><span class="r-pr">#></span> 10: 92.2425 -5.7990 -2.0052 -4.0409 -1.0387 -0.1141 6.9547 2.1239 1.2205 2.8121 0.3113 0.4311 2.3237 0.0323 2.4227 0.0421</span> +<span class="r-out co"><span class="r-pr">#></span> 11: 92.4404 -5.6829 -2.0866 -4.0010 -1.0214 -0.0587 6.6790 2.0177 1.1595 2.6715 0.2957 0.4096 1.9963 0.0407 2.2478 0.0501</span> +<span class="r-out co"><span class="r-pr">#></span> 12: 92.0713 -5.8051 -2.1699 -4.0539 -0.9807 0.0174 6.7885 2.1380 1.1811 2.6017 0.2810 0.3891 1.8480 0.0502 2.0516 0.0522</span> +<span class="r-out co"><span class="r-pr">#></span> 13: 91.7214 -5.6954 -2.1579 -4.0944 -0.9935 -0.0195 6.4491 2.0311 1.1221 2.4716 0.2669 0.3696 1.8299 0.0531 1.9271 0.0520</span> +<span class="r-out co"><span class="r-pr">#></span> 14: 91.1978 -5.6733 -2.1988 -4.0794 -0.9387 0.0091 6.1267 1.9295 1.1589 2.3480 0.2536 0.3511 1.6357 0.0470 1.8899 0.0639</span> +<span class="r-out co"><span class="r-pr">#></span> 15: 91.3746 -5.5864 -2.1484 -4.1356 -0.9126 0.0045 5.8203 1.8330 1.2078 2.3265 0.2409 0.3336 1.6218 0.0428 1.6558 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 16: 91.5646 -5.4931 -2.1474 -4.1242 -0.9148 0.0179 5.5293 1.7414 1.1474 2.2733 0.2288 0.3169 1.6467 0.0377 1.6977 0.0600</span> +<span class="r-out co"><span class="r-pr">#></span> 17: 91.4767 -5.5885 -2.1424 -4.1386 -0.9308 0.0602 5.2528 1.9428 1.2141 2.1762 0.2174 0.3343 1.4916 0.0424 1.4326 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 18: 90.9989 -5.6364 -2.1601 -4.1606 -0.9676 0.0694 4.9902 1.8457 1.2521 2.2899 0.2065 0.3279 1.4504 0.0471 1.4267 0.0700</span> +<span class="r-out co"><span class="r-pr">#></span> 19: 91.4050 -5.7347 -2.0985 -4.1476 -0.9656 0.0668 4.7407 2.3263 1.4064 2.2061 0.1962 0.3296 1.3679 0.0485 1.2735 0.0844</span> +<span class="r-out co"><span class="r-pr">#></span> 20: 91.2707 -5.7623 -2.1155 -4.1538 -0.9601 0.0425 4.5037 2.6509 1.3408 2.1958 0.1864 0.3576 1.3736 0.0452 1.3454 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 21: 91.6878 -5.8143 -2.1261 -4.1649 -0.9325 0.0333 4.7695 2.8996 1.3244 2.1300 0.1771 0.3509 1.4793 0.0508 1.0333 0.0839</span> +<span class="r-out co"><span class="r-pr">#></span> 22: 91.5363 -5.9047 -2.1358 -4.1655 -0.9207 0.0339 4.5310 3.4408 1.3022 2.1829 0.1682 0.3378 1.4260 0.0488 0.9436 0.0877</span> +<span class="r-out co"><span class="r-pr">#></span> 23: 91.9969 -5.9565 -2.1378 -4.1609 -0.9243 0.0701 4.3045 3.7239 1.3446 2.2424 0.1598 0.3209 1.4182 0.0412 0.9205 0.0873</span> +<span class="r-out co"><span class="r-pr">#></span> 24: 92.2835 -5.9272 -2.0883 -4.1651 -0.9248 0.0834 4.0892 3.7780 1.2773 2.2187 0.1518 0.3049 1.4749 0.0427 0.9837 0.0802</span> +<span class="r-out co"><span class="r-pr">#></span> 25: 92.3389 -6.1292 -2.1033 -4.2473 -0.9069 0.0593 3.8848 4.7059 1.2740 2.4323 0.1442 0.2896 1.3656 0.0493 0.9299 0.0798</span> +<span class="r-out co"><span class="r-pr">#></span> 26: 91.9840 -5.9821 -2.1124 -4.2150 -0.9100 0.1076 3.6905 4.4706 1.2103 2.4699 0.1458 0.2751 1.3200 0.0504 0.8256 0.0912</span> +<span class="r-out co"><span class="r-pr">#></span> 27: 92.4671 -5.8765 -2.0910 -4.2169 -0.9356 0.0483 3.5060 4.2471 1.2302 2.4791 0.1385 0.2614 1.4252 0.0520 0.8191 0.0836</span> +<span class="r-out co"><span class="r-pr">#></span> 28: 92.4130 -5.9480 -2.0870 -4.2191 -0.9338 0.0866 3.3859 4.1337 1.2210 2.4685 0.1412 0.2557 1.3860 0.0484 0.9189 0.0770</span> +<span class="r-out co"><span class="r-pr">#></span> 29: 92.3064 -5.7845 -2.0759 -4.2321 -0.9270 0.0855 4.2691 3.9271 1.3369 2.5457 0.1341 0.2922 1.3848 0.0513 0.9658 0.0785</span> +<span class="r-out co"><span class="r-pr">#></span> 30: 92.2109 -5.9347 -2.0725 -4.2042 -0.9074 0.0481 5.5659 3.9234 1.2701 2.4184 0.1370 0.2776 1.2925 0.0560 0.9058 0.0806</span> +<span class="r-out co"><span class="r-pr">#></span> 31: 91.8912 -5.7466 -2.0912 -4.1504 -0.9087 0.0443 5.2876 3.7272 1.2690 2.2975 0.1301 0.2637 1.3348 0.0517 0.8672 0.0840</span> +<span class="r-out co"><span class="r-pr">#></span> 32: 92.3866 -5.8560 -2.0979 -4.1547 -0.9044 0.0335 5.0232 3.5408 1.2761 2.3185 0.1307 0.2505 1.3558 0.0487 0.9422 0.0791</span> +<span class="r-out co"><span class="r-pr">#></span> 33: 92.4555 -5.6989 -2.0956 -4.1479 -0.9038 0.0447 4.7720 3.3638 1.3253 2.2962 0.1242 0.2380 1.4321 0.0432 0.8961 0.0799</span> +<span class="r-out co"><span class="r-pr">#></span> 34: 92.6307 -5.8831 -2.0769 -4.1319 -0.8946 0.0430 4.5334 3.7151 1.2785 2.2638 0.1201 0.2261 1.4076 0.0457 0.8269 0.0813</span> +<span class="r-out co"><span class="r-pr">#></span> 35: 92.5659 -5.9100 -2.0748 -4.1482 -0.9079 0.0563 4.6634 3.7452 1.3141 2.3378 0.1168 0.2148 1.3571 0.0451 0.8317 0.0831</span> +<span class="r-out co"><span class="r-pr">#></span> 36: 92.5738 -5.8574 -2.0981 -4.1214 -0.8963 0.0302 5.3272 3.7371 1.3359 2.2776 0.1331 0.2041 1.3308 0.0480 0.8953 0.0791</span> +<span class="r-out co"><span class="r-pr">#></span> 37: 92.1615 -5.7137 -2.0922 -4.1178 -0.9035 0.0455 5.4894 3.5503 1.2691 2.2508 0.1473 0.1939 1.3692 0.0495 0.9358 0.0800</span> +<span class="r-out co"><span class="r-pr">#></span> 38: 92.4421 -5.6978 -2.0905 -4.1275 -0.9052 0.0108 5.4295 3.3728 1.2057 2.2119 0.1432 0.1842 1.3421 0.0549 0.8932 0.0781</span> +<span class="r-out co"><span class="r-pr">#></span> 39: 92.3995 -5.6121 -2.0804 -4.1275 -0.8903 0.0270 5.1580 3.2041 1.1454 2.2119 0.1360 0.1978 1.3353 0.0524 0.9062 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 40: 92.5616 -5.7907 -2.1099 -4.1127 -0.9074 0.0501 4.9001 3.0439 1.1582 2.1723 0.1387 0.1879 1.2981 0.0510 0.9517 0.0797</span> +<span class="r-out co"><span class="r-pr">#></span> 41: 92.2655 -5.6532 -2.0631 -4.1437 -0.9128 0.0346 4.6551 2.8917 1.1202 2.1498 0.1403 0.1785 1.4500 0.0461 0.7394 0.0903</span> +<span class="r-out co"><span class="r-pr">#></span> 42: 92.3218 -5.4916 -2.1072 -4.1312 -0.9310 0.0360 4.4224 2.7471 1.1648 2.1428 0.1332 0.1695 1.4034 0.0508 0.8131 0.0854</span> +<span class="r-out co"><span class="r-pr">#></span> 43: 92.6165 -5.5145 -2.0838 -4.1239 -0.9215 0.0347 4.2012 2.6098 1.1892 2.1202 0.1463 0.1611 1.3416 0.0507 0.8213 0.0847</span> +<span class="r-out co"><span class="r-pr">#></span> 44: 92.5385 -5.5590 -2.0872 -4.1376 -0.9210 0.0672 3.9912 2.4793 1.1416 2.2253 0.1450 0.1530 1.4008 0.0352 0.8639 0.0847</span> +<span class="r-out co"><span class="r-pr">#></span> 45: 92.2152 -5.6170 -2.1014 -4.1657 -0.9331 0.0781 3.7916 2.4382 1.1250 2.2378 0.1516 0.1556 1.4612 0.0329 1.0091 0.0820</span> +<span class="r-out co"><span class="r-pr">#></span> 46: 91.8943 -5.6650 -2.1329 -4.1649 -0.9241 0.1060 3.6020 2.6448 1.0705 2.3112 0.1441 0.1549 1.5047 0.0384 1.0179 0.0805</span> +<span class="r-out co"><span class="r-pr">#></span> 47: 91.8153 -5.5910 -2.1514 -4.1919 -0.9169 0.0885 3.4219 2.5125 1.0386 2.3140 0.1506 0.1620 1.4759 0.0375 1.1021 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 48: 91.6295 -5.5438 -2.1516 -4.1570 -0.8742 0.0851 3.2508 2.3869 1.0816 2.1983 0.1630 0.1786 1.4024 0.0405 1.1135 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 49: 91.4363 -5.5847 -2.1732 -4.1794 -0.8634 0.0948 3.0883 2.4829 1.0865 2.2378 0.1549 0.1697 1.4314 0.0434 1.0529 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 50: 91.3634 -5.5794 -2.1613 -4.1507 -0.8849 0.0862 2.9339 2.6404 1.0829 2.2519 0.1493 0.1612 1.3704 0.0446 1.0081 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 51: 91.2150 -5.5503 -2.1675 -4.1432 -0.8749 0.1178 2.7872 2.7368 1.0605 2.2261 0.1418 0.1532 1.4312 0.0418 1.0380 0.0781</span> +<span class="r-out co"><span class="r-pr">#></span> 52: 91.4343 -5.6336 -2.2138 -4.1552 -0.8867 0.1391 2.6677 2.7022 1.0857 2.2588 0.1493 0.1455 1.3220 0.0469 0.9272 0.0761</span> +<span class="r-out co"><span class="r-pr">#></span> 53: 91.3310 -5.5185 -2.2340 -4.1430 -0.8855 0.1545 2.9130 2.5670 1.0720 2.3074 0.1532 0.1385 1.3224 0.0503 0.9688 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 54: 91.4342 -5.5008 -2.2086 -4.1777 -0.8720 0.1688 2.8202 2.4387 1.0624 2.4253 0.1631 0.1315 1.3186 0.0429 0.9425 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 55: 91.4983 -5.5944 -2.1709 -4.1211 -0.8638 0.1168 3.4789 2.5154 1.0549 2.3041 0.1557 0.1279 1.3800 0.0423 0.9620 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 56: 91.5954 -5.5317 -2.1881 -4.1263 -0.8627 0.1366 4.1396 2.3896 1.0732 2.2684 0.1562 0.1221 1.3285 0.0431 1.0156 0.0708</span> +<span class="r-out co"><span class="r-pr">#></span> 57: 91.6591 -5.3839 -2.2082 -4.1122 -0.8929 0.1457 4.5073 2.2701 1.0672 2.3639 0.1539 0.1160 1.4074 0.0478 0.9796 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 58: 91.7434 -5.3597 -2.2068 -4.1214 -0.8912 0.1437 4.2819 2.1566 1.0605 2.4496 0.1667 0.1109 1.4274 0.0450 1.0782 0.0676</span> +<span class="r-out co"><span class="r-pr">#></span> 59: 91.6597 -5.4672 -2.1918 -4.1412 -0.9021 0.1657 4.0678 2.0488 1.1306 2.5245 0.1888 0.1054 1.4745 0.0391 1.1492 0.0670</span> +<span class="r-out co"><span class="r-pr">#></span> 60: 91.7565 -5.4513 -2.2051 -4.1618 -0.9013 0.1554 3.8644 1.9464 1.1728 2.6191 0.1793 0.1001 1.4135 0.0402 1.1572 0.0665</span> +<span class="r-out co"><span class="r-pr">#></span> 61: 91.9484 -5.5390 -2.1973 -4.1611 -0.9011 0.1318 3.6712 1.8963 1.1460 2.6242 0.1704 0.0951 1.3855 0.0481 1.1109 0.0634</span> +<span class="r-out co"><span class="r-pr">#></span> 62: 92.1661 -5.4985 -2.1729 -4.1352 -0.8887 0.1327 4.3155 1.8588 1.1087 2.5551 0.1633 0.0995 1.3847 0.0444 1.0736 0.0656</span> +<span class="r-out co"><span class="r-pr">#></span> 63: 92.1727 -5.4086 -2.1610 -4.1488 -0.8998 0.1451 4.6019 1.7659 1.1413 2.6020 0.1718 0.1152 1.4299 0.0404 1.2202 0.0603</span> +<span class="r-out co"><span class="r-pr">#></span> 64: 92.4331 -5.5220 -2.1121 -4.1300 -0.9428 0.1211 5.0354 1.8121 1.0982 2.6157 0.1775 0.1209 1.4168 0.0348 1.2148 0.0625</span> +<span class="r-out co"><span class="r-pr">#></span> 65: 92.1871 -5.6089 -2.1258 -4.1412 -0.9127 0.1399 4.7836 2.1060 1.1568 2.5971 0.1757 0.1148 1.4000 0.0336 1.0305 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 66: 92.1419 -5.7752 -2.1344 -4.1493 -0.9237 0.1494 4.5444 2.7076 1.1563 2.6439 0.1740 0.1091 1.4238 0.0341 1.0285 0.0688</span> +<span class="r-out co"><span class="r-pr">#></span> 67: 92.1187 -5.5967 -2.1430 -4.1460 -0.9074 0.1245 4.3172 2.5722 1.2052 2.6139 0.1868 0.1104 1.4100 0.0381 1.0508 0.0703</span> +<span class="r-out co"><span class="r-pr">#></span> 68: 92.1123 -5.6882 -2.1481 -4.1269 -0.9083 0.1206 4.1014 2.5548 1.2021 2.4832 0.1781 0.1462 1.3099 0.0417 1.0099 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 69: 92.2511 -5.6923 -2.1456 -4.1315 -0.9077 0.1421 4.3551 2.6261 1.1850 2.3591 0.1692 0.1389 1.3546 0.0416 0.9516 0.0762</span> +<span class="r-out co"><span class="r-pr">#></span> 70: 92.0291 -5.7376 -2.1689 -4.1364 -0.8908 0.1407 4.1373 3.0520 1.1595 2.2495 0.1608 0.1465 1.3226 0.0436 0.9904 0.0711</span> +<span class="r-out co"><span class="r-pr">#></span> 71: 91.7690 -5.7223 -2.1773 -4.1986 -0.9036 0.1831 3.9304 2.8994 1.1015 2.4335 0.1527 0.1602 1.3135 0.0450 0.9564 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 72: 91.4802 -5.7302 -2.2079 -4.2000 -0.8990 0.2112 3.7339 3.2965 1.1222 2.4612 0.1451 0.1622 1.3222 0.0426 1.0215 0.0717</span> +<span class="r-out co"><span class="r-pr">#></span> 73: 91.1247 -5.7803 -2.1827 -4.2214 -0.8876 0.1385 3.5472 3.2786 1.1612 2.5216 0.1650 0.1541 1.2811 0.0493 1.0076 0.0696</span> +<span class="r-out co"><span class="r-pr">#></span> 74: 90.9765 -5.6534 -2.1808 -4.2511 -0.8824 0.1308 3.8553 3.1146 1.1389 2.8140 0.1725 0.1464 1.2895 0.0518 1.0100 0.0707</span> +<span class="r-out co"><span class="r-pr">#></span> 75: 90.4805 -5.7293 -2.1481 -4.2613 -0.8704 0.1395 4.1255 2.9589 1.1623 2.7523 0.1713 0.1391 1.3112 0.0483 0.9439 0.0788</span> +<span class="r-out co"><span class="r-pr">#></span> 76: 90.3958 -5.7635 -2.1508 -4.2426 -0.8841 0.1402 4.7427 3.0223 1.2187 2.7243 0.1789 0.1321 1.3065 0.0468 0.9303 0.0758</span> +<span class="r-out co"><span class="r-pr">#></span> 77: 90.7518 -5.6517 -2.1498 -4.2773 -0.8730 0.1688 5.9340 2.8712 1.1840 2.8530 0.1828 0.1255 1.3553 0.0422 0.9755 0.0696</span> +<span class="r-out co"><span class="r-pr">#></span> 78: 91.0443 -5.7462 -2.1351 -4.2601 -0.8848 0.1746 5.6373 2.9912 1.1312 2.7659 0.1887 0.1192 1.3303 0.0410 0.8578 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 79: 90.9631 -5.7307 -2.1618 -4.2593 -0.8965 0.1944 5.7520 3.1324 1.1206 2.8212 0.1875 0.1340 1.3519 0.0449 0.9006 0.0799</span> +<span class="r-out co"><span class="r-pr">#></span> 80: 90.8703 -5.7665 -2.1989 -4.2476 -0.9122 0.1933 5.4644 3.4527 1.1063 2.7920 0.1781 0.1273 1.3014 0.0497 0.9305 0.0792</span> +<span class="r-out co"><span class="r-pr">#></span> 81: 90.7781 -5.8702 -2.1789 -4.2821 -0.8828 0.1793 5.1912 3.7553 1.0662 3.0568 0.1807 0.1209 1.3120 0.0472 0.9808 0.0772</span> +<span class="r-out co"><span class="r-pr">#></span> 82: 90.8137 -6.1164 -2.2001 -4.3046 -0.8912 0.1916 4.9316 4.9023 1.0714 3.1363 0.1716 0.1149 1.2724 0.0539 1.0644 0.0693</span> +<span class="r-out co"><span class="r-pr">#></span> 83: 90.9900 -6.2077 -2.1695 -4.3121 -0.8924 0.1722 6.7123 5.3290 1.1120 3.2733 0.1741 0.1091 1.2822 0.0510 1.0142 0.0715</span> +<span class="r-out co"><span class="r-pr">#></span> 84: 90.8158 -6.3282 -2.1595 -4.2907 -0.9096 0.1818 6.3767 5.9725 1.1342 3.2384 0.1763 0.1037 1.2704 0.0420 0.8891 0.0834</span> +<span class="r-out co"><span class="r-pr">#></span> 85: 90.5926 -6.2052 -2.1643 -4.2780 -0.9000 0.1579 6.0579 5.6739 1.1472 3.0765 0.1751 0.0985 1.3263 0.0433 0.9484 0.0814</span> +<span class="r-out co"><span class="r-pr">#></span> 86: 90.3804 -6.2707 -2.1470 -4.2627 -0.9260 0.1650 5.7550 5.5542 1.1135 2.9227 0.1956 0.0936 1.2747 0.0447 0.9731 0.0780</span> +<span class="r-out co"><span class="r-pr">#></span> 87: 90.8425 -6.4455 -2.1135 -4.2273 -0.9294 0.1491 5.4672 6.8599 1.0716 2.7765 0.1858 0.0928 1.3204 0.0427 1.0005 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 88: 91.2019 -6.2302 -2.1362 -4.1982 -0.9333 0.1615 5.1939 6.5169 1.1221 2.7203 0.1841 0.0928 1.2689 0.0466 0.9914 0.0771</span> +<span class="r-out co"><span class="r-pr">#></span> 89: 90.9907 -6.4173 -2.1174 -4.2493 -0.9182 0.1628 4.9342 6.2408 1.1719 2.9614 0.1749 0.1021 1.3580 0.0403 1.0171 0.0775</span> +<span class="r-out co"><span class="r-pr">#></span> 90: 91.1666 -6.5154 -2.1219 -4.2011 -0.9210 0.1594 4.6875 7.4895 1.1930 2.8133 0.1745 0.0970 1.2500 0.0432 0.9467 0.0799</span> +<span class="r-out co"><span class="r-pr">#></span> 91: 91.0165 -6.5918 -2.1465 -4.2231 -0.9079 0.1382 4.9772 7.3172 1.1706 2.6789 0.1810 0.1032 1.2958 0.0458 1.1223 0.0639</span> +<span class="r-out co"><span class="r-pr">#></span> 92: 91.5386 -6.6567 -2.1376 -4.2247 -0.9358 0.1696 5.5955 7.4188 1.1543 2.6339 0.1754 0.0980 1.2894 0.0463 0.9927 0.0764</span> +<span class="r-out co"><span class="r-pr">#></span> 93: 92.2552 -6.5096 -2.1645 -4.2340 -0.9393 0.1798 5.3157 7.0479 1.1612 2.6312 0.1718 0.0931 1.3698 0.0431 1.2649 0.0579</span> +<span class="r-out co"><span class="r-pr">#></span> 94: 91.7588 -6.4124 -2.1795 -4.2305 -0.9265 0.1842 5.8275 6.6955 1.1988 2.6403 0.1891 0.0884 1.3022 0.0481 1.0741 0.0713</span> +<span class="r-out co"><span class="r-pr">#></span> 95: 91.6694 -6.2975 -2.1946 -4.2442 -0.9392 0.2004 5.5361 6.3607 1.1399 2.7164 0.1796 0.1027 1.2519 0.0513 1.0982 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 96: 91.2252 -6.0124 -2.2316 -4.2701 -0.8946 0.2375 5.2593 6.0427 1.0829 2.7921 0.2024 0.1147 1.3343 0.0426 1.3064 0.0560</span> +<span class="r-out co"><span class="r-pr">#></span> 97: 91.0388 -5.9178 -2.2563 -4.2703 -0.9093 0.2304 5.6825 5.7405 1.0890 2.7678 0.2113 0.1090 1.3517 0.0484 1.4160 0.0493</span> +<span class="r-out co"><span class="r-pr">#></span> 98: 90.9013 -6.1325 -2.2597 -4.2776 -0.9133 0.2447 5.7546 5.4535 1.1028 2.6806 0.2130 0.1182 1.2983 0.0451 1.2436 0.0584</span> +<span class="r-out co"><span class="r-pr">#></span> 99: 91.2086 -6.0047 -2.2719 -4.2972 -0.9136 0.2738 5.4668 5.1808 1.1776 2.7160 0.2132 0.1123 1.3301 0.0431 1.1850 0.0628</span> +<span class="r-out co"><span class="r-pr">#></span> 100: 91.3181 -5.9175 -2.2311 -4.3202 -0.8947 0.2844 5.1935 4.9218 1.1187 2.8660 0.2289 0.1471 1.3409 0.0371 0.9566 0.0806</span> +<span class="r-out co"><span class="r-pr">#></span> 101: 91.5112 -5.7721 -2.2292 -4.3060 -0.8842 0.3006 6.3617 4.6757 1.0628 2.7227 0.2174 0.1500 1.3269 0.0407 1.2002 0.0592</span> +<span class="r-out co"><span class="r-pr">#></span> 102: 91.5205 -5.9982 -2.2162 -4.3041 -0.8813 0.3065 7.7957 4.4419 1.0320 2.7176 0.2290 0.1474 1.3218 0.0392 0.9685 0.0783</span> +<span class="r-out co"><span class="r-pr">#></span> 103: 91.2416 -5.7012 -2.2204 -4.3198 -0.8610 0.3180 7.4059 4.2198 1.0242 2.5817 0.2175 0.1714 1.3003 0.0395 0.9472 0.0825</span> +<span class="r-out co"><span class="r-pr">#></span> 104: 91.2662 -5.8136 -2.2357 -4.3063 -0.8700 0.3110 7.0356 4.0088 1.0024 2.4701 0.2067 0.1939 1.2806 0.0407 1.0387 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 105: 91.4688 -5.7922 -2.2204 -4.3319 -0.8703 0.2767 6.6838 3.8084 0.9751 2.6368 0.1963 0.1967 1.3320 0.0470 1.2043 0.0580</span> +<span class="r-out co"><span class="r-pr">#></span> 106: 91.3665 -5.8505 -2.2225 -4.3614 -0.8757 0.2922 7.1982 3.6180 1.0018 2.6378 0.1865 0.2132 1.2613 0.0464 1.0683 0.0693</span> +<span class="r-out co"><span class="r-pr">#></span> 107: 91.4934 -5.8933 -2.1993 -4.3433 -0.9112 0.3267 6.8383 3.7379 0.9616 2.5329 0.1772 0.2169 1.2911 0.0449 1.0688 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 108: 92.1268 -5.7807 -2.1863 -4.4348 -0.9273 0.3235 6.4964 3.5510 1.0093 2.9025 0.1718 0.2061 1.3153 0.0414 0.8982 0.0796</span> +<span class="r-out co"><span class="r-pr">#></span> 109: 91.6585 -5.9778 -2.2083 -4.3550 -0.9061 0.3339 6.1715 4.5778 1.0600 2.7574 0.1755 0.2163 1.2754 0.0382 0.8100 0.0868</span> +<span class="r-out co"><span class="r-pr">#></span> 110: 92.0456 -5.6784 -2.2236 -4.3483 -0.8911 0.3022 5.8630 4.3489 1.0427 2.6195 0.1667 0.2472 1.3782 0.0336 0.7819 0.0931</span> +<span class="r-out co"><span class="r-pr">#></span> 111: 92.2862 -5.6624 -2.1985 -4.3680 -0.9178 0.3156 5.5698 4.1315 1.0149 2.5443 0.1622 0.2348 1.3541 0.0415 0.7848 0.0868</span> +<span class="r-out co"><span class="r-pr">#></span> 112: 92.5436 -5.6572 -2.2134 -4.3290 -0.9267 0.3025 5.2913 3.9249 1.0720 2.5118 0.1541 0.2231 1.3798 0.0385 0.9087 0.0799</span> +<span class="r-out co"><span class="r-pr">#></span> 113: 92.5970 -5.6263 -2.2030 -4.3044 -0.9123 0.2856 5.0268 3.7287 1.1371 2.4674 0.1764 0.2119 1.3007 0.0455 0.8651 0.0850</span> +<span class="r-out co"><span class="r-pr">#></span> 114: 92.9227 -5.6379 -2.2032 -4.2926 -0.9187 0.3282 4.7754 3.5422 1.1022 2.4105 0.1676 0.2013 1.3103 0.0439 0.9003 0.0815</span> +<span class="r-out co"><span class="r-pr">#></span> 115: 92.7678 -5.8033 -2.1888 -4.2988 -0.9406 0.3026 4.5367 3.3651 1.1127 2.5043 0.1592 0.1913 1.3643 0.0420 0.9649 0.0800</span> +<span class="r-out co"><span class="r-pr">#></span> 116: 92.0655 -5.8531 -2.2033 -4.2989 -0.9487 0.3013 4.3098 3.6792 1.1260 2.4981 0.1513 0.1817 1.2783 0.0445 0.9812 0.0818</span> +<span class="r-out co"><span class="r-pr">#></span> 117: 92.2258 -5.7861 -2.2095 -4.3393 -0.9399 0.2998 4.0943 3.4952 1.0697 2.7102 0.1437 0.1752 1.3037 0.0426 0.9067 0.0786</span> +<span class="r-out co"><span class="r-pr">#></span> 118: 92.3560 -5.8080 -2.2058 -4.3166 -0.9480 0.2743 4.6025 3.3205 1.0709 2.6198 0.1432 0.1747 1.2850 0.0481 0.9236 0.0769</span> +<span class="r-out co"><span class="r-pr">#></span> 119: 92.0489 -5.7726 -2.1972 -4.2740 -0.9087 0.2627 4.3723 3.1544 1.0892 2.4888 0.1620 0.1660 1.2659 0.0435 0.8389 0.0832</span> +<span class="r-out co"><span class="r-pr">#></span> 120: 91.9163 -5.8211 -2.2101 -4.2770 -0.9142 0.2674 4.1537 3.1700 1.0985 2.5003 0.1795 0.1577 1.2289 0.0454 0.9280 0.0826</span> +<span class="r-out co"><span class="r-pr">#></span> 121: 92.0274 -5.7601 -2.1916 -4.2686 -0.9055 0.2571 3.9460 3.1181 1.1026 2.3985 0.1908 0.1498 1.3015 0.0432 0.9363 0.0807</span> +<span class="r-out co"><span class="r-pr">#></span> 122: 92.2933 -5.7972 -2.2019 -4.2888 -0.8932 0.2679 3.7487 3.1755 1.0809 2.3976 0.1843 0.1636 1.2918 0.0433 0.8760 0.0803</span> +<span class="r-out co"><span class="r-pr">#></span> 123: 92.3361 -5.8903 -2.1745 -4.3386 -0.9157 0.2665 3.5613 3.8794 1.1308 2.5838 0.1751 0.1555 1.3219 0.0421 0.8987 0.0806</span> +<span class="r-out co"><span class="r-pr">#></span> 124: 92.5677 -6.0471 -2.1638 -4.2764 -0.9325 0.2645 3.3832 4.6152 1.1336 2.4546 0.1664 0.1526 1.2938 0.0375 0.9412 0.0798</span> +<span class="r-out co"><span class="r-pr">#></span> 125: 92.7852 -5.9841 -2.1661 -4.2825 -0.9373 0.2866 3.2141 4.3844 1.0770 2.3788 0.1581 0.1727 1.3137 0.0417 0.9228 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 126: 92.7867 -5.9126 -2.1636 -4.2413 -0.9141 0.2756 3.0534 4.1652 1.0857 2.2921 0.1502 0.1994 1.2428 0.0450 0.8206 0.0795</span> +<span class="r-out co"><span class="r-pr">#></span> 127: 92.8733 -5.9110 -2.1546 -4.2269 -0.9258 0.2531 2.9007 3.9569 1.0914 2.3822 0.1426 0.2029 1.3043 0.0369 0.8206 0.0795</span> +<span class="r-out co"><span class="r-pr">#></span> 128: 93.0457 -5.9202 -2.1505 -4.2076 -0.9466 0.2463 3.3353 3.7591 1.0647 2.3012 0.1355 0.2180 1.3420 0.0385 0.8503 0.0803</span> +<span class="r-out co"><span class="r-pr">#></span> 129: 92.9207 -5.9882 -2.1704 -4.2204 -0.9319 0.2464 4.3160 4.4368 1.1187 2.3415 0.1386 0.2316 1.2546 0.0435 0.8777 0.0830</span> +<span class="r-out co"><span class="r-pr">#></span> 130: 92.2660 -6.2043 -2.1712 -4.2251 -0.9276 0.2186 4.4370 5.1440 1.0817 2.3426 0.1338 0.2200 1.2733 0.0476 0.9132 0.0753</span> +<span class="r-out co"><span class="r-pr">#></span> 131: 92.1286 -6.4163 -2.1634 -4.2642 -0.9223 0.2300 4.2151 6.2253 1.0614 2.5012 0.1333 0.2090 1.2690 0.0430 0.8201 0.0814</span> +<span class="r-out co"><span class="r-pr">#></span> 132: 92.0287 -6.4297 -2.1522 -4.2717 -0.9259 0.2250 4.0044 6.1979 1.0791 2.5146 0.1314 0.1985 1.2736 0.0449 0.8671 0.0784</span> +<span class="r-out co"><span class="r-pr">#></span> 133: 91.6843 -6.1415 -2.1685 -4.2553 -0.9349 0.2209 3.8041 5.8880 1.1445 2.4277 0.1248 0.2026 1.3381 0.0426 0.9129 0.0858</span> +<span class="r-out co"><span class="r-pr">#></span> 134: 91.6928 -6.1408 -2.1467 -4.2709 -0.9270 0.2648 3.6139 5.5936 1.0873 2.5602 0.1305 0.1925 1.3202 0.0416 0.7626 0.0936</span> +<span class="r-out co"><span class="r-pr">#></span> 135: 91.7984 -6.0371 -2.1673 -4.2572 -0.9497 0.2480 3.4332 5.3139 1.0649 2.4322 0.1389 0.1829 1.2592 0.0544 0.9459 0.0831</span> +<span class="r-out co"><span class="r-pr">#></span> 136: 91.9754 -6.1770 -2.1769 -4.2311 -0.9401 0.2435 3.2616 5.0482 1.0717 2.3106 0.1691 0.1737 1.3170 0.0436 1.0497 0.0816</span> +<span class="r-out co"><span class="r-pr">#></span> 137: 92.1546 -6.1216 -2.1731 -4.2278 -0.9401 0.2492 3.0985 4.9378 1.0200 2.1950 0.1606 0.1988 1.4019 0.0421 1.0200 0.0766</span> +<span class="r-out co"><span class="r-pr">#></span> 138: 92.2370 -5.9463 -2.1794 -4.1949 -0.9321 0.2460 2.9436 4.6909 1.0203 2.1200 0.1535 0.1947 1.3378 0.0425 0.9448 0.0804</span> +<span class="r-out co"><span class="r-pr">#></span> 139: 92.2025 -5.8849 -2.1820 -4.1868 -0.9200 0.2294 2.9458 4.4564 0.9875 2.1260 0.1759 0.2080 1.3244 0.0428 1.0110 0.0778</span> +<span class="r-out co"><span class="r-pr">#></span> 140: 91.8182 -5.7494 -2.1569 -4.1998 -0.9095 0.2318 2.7985 4.2336 1.0015 2.1507 0.1830 0.2113 1.3502 0.0432 0.7716 0.0922</span> +<span class="r-out co"><span class="r-pr">#></span> 141: 91.8292 -5.9568 -2.1640 -4.2109 -0.9122 0.2130 4.4608 4.0219 1.0180 2.1032 0.1739 0.2057 1.3594 0.0419 0.8088 0.0883</span> +<span class="r-out co"><span class="r-pr">#></span> 142: 91.9995 -6.0927 -2.1471 -4.2313 -0.9091 0.1875 4.5415 4.7705 1.0571 2.1286 0.1810 0.1954 1.4145 0.0406 0.8943 0.0847</span> +<span class="r-out co"><span class="r-pr">#></span> 143: 91.9160 -5.9892 -2.1546 -4.2043 -0.9355 0.1819 4.3145 4.5320 1.1337 2.1453 0.1888 0.2208 1.3449 0.0394 1.0910 0.0797</span> +<span class="r-out co"><span class="r-pr">#></span> 144: 92.0136 -5.9765 -2.1643 -4.2346 -0.9448 0.2455 4.3041 4.3054 1.1130 2.1300 0.1817 0.3253 1.3828 0.0340 1.0535 0.0873</span> +<span class="r-out co"><span class="r-pr">#></span> 145: 92.3893 -6.2224 -2.1211 -4.2316 -0.9405 0.2285 5.2279 4.9099 1.0573 2.1037 0.1727 0.3091 1.3797 0.0340 1.0160 0.0832</span> +<span class="r-out co"><span class="r-pr">#></span> 146: 92.6097 -6.2204 -2.1406 -4.2210 -0.9217 0.1762 4.9665 5.4466 1.0724 2.1658 0.1640 0.2936 1.4421 0.0408 1.2412 0.0674</span> +<span class="r-out co"><span class="r-pr">#></span> 147: 92.8499 -6.0091 -2.1165 -4.2234 -0.9682 0.1783 4.7182 5.1743 1.0188 2.1714 0.1722 0.2789 1.4545 0.0397 1.4472 0.0556</span> +<span class="r-out co"><span class="r-pr">#></span> 148: 92.6602 -5.8003 -2.1059 -4.2132 -0.9282 0.2102 4.4823 4.9156 1.0106 2.1075 0.1880 0.2684 1.4013 0.0413 1.0748 0.0758</span> +<span class="r-out co"><span class="r-pr">#></span> 149: 92.7388 -5.8727 -2.1569 -4.2185 -0.9266 0.1868 4.2581 4.6698 1.1447 2.0851 0.1786 0.2550 1.3137 0.0413 0.9963 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 150: 92.7348 -5.7926 -2.1184 -4.2257 -0.9324 0.1966 4.0452 4.4363 1.1760 2.1508 0.1697 0.2704 1.3792 0.0363 0.8204 0.0889</span> +<span class="r-out co"><span class="r-pr">#></span> 151: 92.7968 -5.7301 -2.1179 -4.1959 -0.9275 0.1927 3.8430 4.2145 1.1707 2.1702 0.1842 0.2569 1.3789 0.0387 0.7890 0.0873</span> +<span class="r-out co"><span class="r-pr">#></span> 152: 92.9011 -5.7417 -2.1622 -4.2086 -0.9215 0.1784 2.0089 3.0670 1.1984 2.2253 0.1814 0.2507 1.3431 0.0395 0.9622 0.0780</span> +<span class="r-out co"><span class="r-pr">#></span> 153: 92.8020 -5.7707 -2.1494 -4.2128 -0.9228 0.1818 2.2261 2.9648 1.1192 2.3058 0.1749 0.2548 1.3671 0.0369 0.9507 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 154: 92.5217 -5.8043 -2.1447 -4.2074 -0.9303 0.1766 2.7638 3.1314 1.1141 2.2814 0.1811 0.2389 1.3250 0.0408 1.0538 0.0689</span> +<span class="r-out co"><span class="r-pr">#></span> 155: 92.8765 -5.5586 -2.1275 -4.1639 -0.9320 0.1434 2.4217 2.4658 1.1231 2.1314 0.1746 0.2426 1.3785 0.0407 0.9682 0.0796</span> +<span class="r-out co"><span class="r-pr">#></span> 156: 93.0074 -5.6819 -2.1343 -4.1819 -0.9382 0.1587 1.4756 2.7496 1.1200 2.1700 0.1849 0.2320 1.3643 0.0395 1.0875 0.0653</span> +<span class="r-out co"><span class="r-pr">#></span> 157: 92.7950 -5.6827 -2.1178 -4.1808 -0.9553 0.1585 1.1607 2.5156 1.1129 2.2109 0.1724 0.2366 1.4045 0.0374 1.1322 0.0676</span> +<span class="r-out co"><span class="r-pr">#></span> 158: 92.7684 -5.7106 -2.0933 -4.2149 -0.9717 0.1602 1.4884 2.6532 1.1269 2.1388 0.1838 0.2666 1.4009 0.0348 0.8728 0.0832</span> +<span class="r-out co"><span class="r-pr">#></span> 159: 93.0980 -5.8911 -2.1297 -4.2160 -0.9660 0.1407 1.6034 3.3765 1.1182 2.1661 0.1705 0.2804 1.3557 0.0430 1.0076 0.0776</span> +<span class="r-out co"><span class="r-pr">#></span> 160: 93.1849 -5.9433 -2.1177 -4.1735 -0.9436 0.1324 1.8692 4.0887 1.1252 2.0213 0.1642 0.2922 1.3251 0.0386 0.8586 0.0820</span> +<span class="r-out co"><span class="r-pr">#></span> 161: 93.4771 -5.7768 -2.0899 -4.1697 -0.9670 0.1043 2.0938 2.9110 1.1069 1.9538 0.1820 0.3046 1.3270 0.0413 0.8220 0.0855</span> +<span class="r-out co"><span class="r-pr">#></span> 162: 93.4961 -5.6516 -2.0965 -4.1633 -0.9708 0.1263 2.2053 2.3022 1.1179 1.9555 0.1758 0.2891 1.3158 0.0417 0.9943 0.0768</span> +<span class="r-out co"><span class="r-pr">#></span> 163: 93.1627 -5.5944 -2.1527 -4.1633 -0.9488 0.1452 2.9600 2.3291 1.1027 1.9555 0.1766 0.3000 1.3626 0.0376 0.9790 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 164: 92.7951 -5.6646 -2.1539 -4.1699 -0.9447 0.1863 2.9195 2.7599 1.0794 1.9511 0.1651 0.2918 1.4091 0.0357 1.1005 0.0709</span> +<span class="r-out co"><span class="r-pr">#></span> 165: 92.6045 -5.5927 -2.1842 -4.1770 -0.9436 0.1939 2.2014 2.3213 1.0622 1.9775 0.1671 0.2899 1.3945 0.0372 1.0533 0.0694</span> +<span class="r-out co"><span class="r-pr">#></span> 166: 92.6660 -5.5922 -2.1438 -4.1611 -0.9441 0.1767 1.8951 2.3445 1.1025 2.0399 0.1802 0.2802 1.4229 0.0354 1.1552 0.0682</span> +<span class="r-out co"><span class="r-pr">#></span> 167: 92.4353 -5.5118 -2.1415 -4.1730 -0.9124 0.1827 1.5029 1.8145 1.0701 2.0090 0.1727 0.2642 1.4525 0.0362 1.0577 0.0754</span> +<span class="r-out co"><span class="r-pr">#></span> 168: 92.3761 -5.5522 -2.1625 -4.1911 -0.9114 0.1782 1.2703 2.0808 1.0814 2.0588 0.1810 0.2658 1.3973 0.0364 0.9874 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 169: 92.5240 -5.6102 -2.1396 -4.1793 -0.8972 0.1722 1.3115 2.2750 1.0759 2.0910 0.2147 0.2549 1.3553 0.0392 0.9770 0.0759</span> +<span class="r-out co"><span class="r-pr">#></span> 170: 92.3827 -5.5942 -2.1231 -4.1847 -0.9338 0.1525 1.5707 2.3778 1.0542 2.0824 0.2042 0.2519 1.4424 0.0363 1.1270 0.0687</span> +<span class="r-out co"><span class="r-pr">#></span> 171: 92.1706 -5.6171 -2.1619 -4.1926 -0.9056 0.1390 1.0935 2.2869 1.1239 2.1697 0.1946 0.2624 1.2980 0.0411 0.9988 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 172: 92.1491 -5.5704 -2.1447 -4.1913 -0.9285 0.1649 1.0292 2.2160 1.1231 2.1905 0.1860 0.2518 1.3154 0.0375 1.0152 0.0772</span> +<span class="r-out co"><span class="r-pr">#></span> 173: 91.9987 -5.5411 -2.1434 -4.1803 -0.9056 0.1585 0.6511 1.9989 1.0892 2.2283 0.1899 0.2413 1.3814 0.0380 1.1733 0.0693</span> +<span class="r-out co"><span class="r-pr">#></span> 174: 92.0377 -5.5419 -2.1081 -4.1928 -0.9057 0.1418 0.9013 2.0933 1.1813 2.2773 0.1756 0.2559 1.4419 0.0343 0.9942 0.0801</span> +<span class="r-out co"><span class="r-pr">#></span> 175: 92.0266 -5.5125 -2.1014 -4.1775 -0.9119 0.1371 0.7194 2.0624 1.1848 2.2328 0.1754 0.2504 1.3987 0.0353 1.0838 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 176: 92.0365 -5.5658 -2.0914 -4.1646 -0.8956 0.1096 0.7557 2.0588 1.1642 2.1610 0.1617 0.2722 1.3658 0.0347 0.9405 0.0757</span> +<span class="r-out co"><span class="r-pr">#></span> 177: 91.8661 -5.6799 -2.0950 -4.1695 -0.9010 0.1193 0.8835 2.8899 1.1394 2.1886 0.1809 0.2777 1.3841 0.0351 0.9178 0.0794</span> +<span class="r-out co"><span class="r-pr">#></span> 178: 91.9392 -5.7853 -2.1139 -4.1711 -0.9190 0.1222 0.6673 3.0461 1.1712 2.1948 0.1576 0.2237 1.3623 0.0383 0.9060 0.0795</span> +<span class="r-out co"><span class="r-pr">#></span> 179: 92.0116 -5.7560 -2.1418 -4.1711 -0.9153 0.1034 0.4356 2.9139 1.1653 2.1948 0.1497 0.2364 1.3387 0.0392 0.9327 0.0793</span> +<span class="r-out co"><span class="r-pr">#></span> 180: 92.1013 -5.7920 -2.1368 -4.1654 -0.9059 0.0912 0.3859 3.2592 1.1357 2.1744 0.1570 0.2337 1.3622 0.0408 1.0299 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 181: 92.1032 -5.8125 -2.1260 -4.1791 -0.9404 0.1731 0.4091 3.0817 1.1113 2.2356 0.1572 0.2742 1.4509 0.0340 0.9180 0.0865</span> +<span class="r-out co"><span class="r-pr">#></span> 182: 92.1315 -5.7991 -2.1327 -4.1737 -0.9319 0.1519 0.3145 3.0292 1.1520 2.1360 0.1661 0.2482 1.4105 0.0361 1.1338 0.0748</span> +<span class="r-out co"><span class="r-pr">#></span> 183: 92.1350 -6.0470 -2.1264 -4.1707 -0.9525 0.1787 0.2045 3.8296 1.1229 2.1369 0.1735 0.2453 1.3132 0.0350 1.0507 0.0759</span> +<span class="r-out co"><span class="r-pr">#></span> 184: 92.0539 -5.9856 -2.1289 -4.1968 -0.9281 0.1789 0.1166 3.9425 1.0558 2.2320 0.1658 0.2253 1.3390 0.0355 1.1271 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 185: 92.0755 -6.0524 -2.1385 -4.2076 -0.9313 0.1794 0.1193 4.2430 1.0465 2.3571 0.1566 0.2152 1.3777 0.0368 1.2013 0.0631</span> +<span class="r-out co"><span class="r-pr">#></span> 186: 92.1639 -6.0663 -2.1399 -4.1869 -0.9311 0.1817 0.1392 4.4053 1.0495 2.4857 0.1532 0.2331 1.3751 0.0365 1.0497 0.0697</span> +<span class="r-out co"><span class="r-pr">#></span> 187: 92.1759 -6.3052 -2.1469 -4.2221 -0.9428 0.1970 0.1356 5.5622 0.9953 2.3367 0.1451 0.2359 1.3754 0.0367 1.0969 0.0656</span> +<span class="r-out co"><span class="r-pr">#></span> 188: 92.1744 -6.0494 -2.1406 -4.2445 -0.9595 0.2089 0.1364 4.3818 0.9882 2.4074 0.1480 0.2364 1.3709 0.0396 1.1259 0.0642</span> +<span class="r-out co"><span class="r-pr">#></span> 189: 92.1989 -6.1255 -2.1138 -4.2037 -0.9368 0.1796 0.1444 4.6756 0.9840 2.3786 0.1502 0.2303 1.3979 0.0393 1.2011 0.0630</span> +<span class="r-out co"><span class="r-pr">#></span> 190: 92.0944 -6.1343 -2.1536 -4.2106 -0.9267 0.2105 0.1288 4.4977 1.0475 2.3593 0.1443 0.2396 1.3247 0.0384 1.1304 0.0711</span> +<span class="r-out co"><span class="r-pr">#></span> 191: 92.1238 -6.0639 -2.1462 -4.2883 -0.9311 0.2155 0.1246 4.1066 1.0428 2.6836 0.1442 0.2344 1.4041 0.0344 1.1631 0.0684</span> +<span class="r-out co"><span class="r-pr">#></span> 192: 92.1328 -6.0743 -2.1232 -4.3119 -0.9586 0.2319 0.1192 4.1348 1.0020 2.7067 0.1466 0.2515 1.4039 0.0355 1.0021 0.0772</span> +<span class="r-out co"><span class="r-pr">#></span> 193: 92.0881 -5.8697 -2.1298 -4.2691 -0.9309 0.2295 0.1050 3.4476 0.9879 2.5496 0.1344 0.2348 1.4677 0.0351 1.0332 0.0705</span> +<span class="r-out co"><span class="r-pr">#></span> 194: 92.1086 -5.7557 -2.1176 -4.3249 -0.9029 0.2183 0.0702 2.7793 1.0043 2.8853 0.1460 0.2213 1.4733 0.0325 1.0929 0.0681</span> +<span class="r-out co"><span class="r-pr">#></span> 195: 92.1265 -5.8976 -2.1506 -4.2932 -0.9267 0.2511 0.0593 3.4959 0.9881 2.6806 0.1278 0.2505 1.6138 0.0350 1.1327 0.0703</span> +<span class="r-out co"><span class="r-pr">#></span> 196: 92.1316 -5.7018 -2.1627 -4.2889 -0.9278 0.2392 0.0717 2.9210 1.0160 2.7067 0.1470 0.2350 1.5063 0.0418 1.0525 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 197: 92.1756 -5.7899 -2.1604 -4.2819 -0.9248 0.2765 0.0754 2.9991 1.0167 2.6170 0.1465 0.2314 1.4982 0.0387 1.0504 0.0774</span> +<span class="r-out co"><span class="r-pr">#></span> 198: 92.2153 -5.8248 -2.1571 -4.2245 -0.9350 0.2195 0.0651 3.0128 0.9196 2.3123 0.1451 0.2363 1.3965 0.0453 1.1561 0.0650</span> +<span class="r-out co"><span class="r-pr">#></span> 199: 92.1935 -5.8187 -2.1505 -4.2123 -0.9452 0.2406 0.0535 3.0017 0.9553 2.2771 0.1338 0.2415 1.4485 0.0407 1.0647 0.0699</span> +<span class="r-out co"><span class="r-pr">#></span> 200: 92.2308 -5.6732 -2.1578 -4.2182 -0.9324 0.2330 0.0618 2.4070 1.0687 2.2978 0.1513 0.2199 1.4101 0.0385 1.0283 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 201: 92.2305 -5.6796 -2.1604 -4.2064 -0.9320 0.2262 0.0530 2.4360 1.0551 2.2994 0.1529 0.2219 1.3653 0.0407 1.0115 0.0757</span> +<span class="r-out co"><span class="r-pr">#></span> 202: 92.2259 -5.7201 -2.1550 -4.2058 -0.9263 0.2208 0.0461 2.6422 1.0351 2.2888 0.1520 0.2100 1.3739 0.0418 1.0474 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 203: 92.2212 -5.7539 -2.1457 -4.2037 -0.9303 0.2163 0.0422 2.8480 1.0403 2.2723 0.1465 0.2070 1.3973 0.0404 1.0518 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 204: 92.2164 -5.8068 -2.1371 -4.2093 -0.9300 0.2163 0.0383 3.1313 1.0426 2.2984 0.1423 0.2091 1.4025 0.0391 1.0284 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 205: 92.2120 -5.8371 -2.1369 -4.2142 -0.9308 0.2156 0.0347 3.2786 1.0392 2.3249 0.1390 0.2048 1.4115 0.0385 1.0161 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 206: 92.2071 -5.8681 -2.1391 -4.2176 -0.9287 0.2158 0.0336 3.4917 1.0442 2.3461 0.1388 0.2041 1.4017 0.0394 0.9977 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 207: 92.2078 -5.8966 -2.1424 -4.2230 -0.9286 0.2181 0.0337 3.6741 1.0456 2.3743 0.1369 0.2009 1.3988 0.0397 0.9792 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 208: 92.2077 -5.8972 -2.1459 -4.2249 -0.9300 0.2208 0.0340 3.6775 1.0460 2.3889 0.1362 0.1985 1.3969 0.0394 0.9729 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 209: 92.2091 -5.8831 -2.1488 -4.2271 -0.9326 0.2227 0.0337 3.6019 1.0465 2.4005 0.1380 0.1967 1.3949 0.0395 0.9745 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 210: 92.2115 -5.8806 -2.1490 -4.2282 -0.9349 0.2238 0.0324 3.5652 1.0516 2.4211 0.1386 0.1979 1.3941 0.0391 0.9820 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 211: 92.2151 -5.8791 -2.1516 -4.2291 -0.9363 0.2258 0.0318 3.5315 1.0458 2.4465 0.1390 0.1989 1.3918 0.0394 0.9901 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 212: 92.2189 -5.8789 -2.1532 -4.2297 -0.9380 0.2269 0.0312 3.4989 1.0434 2.4718 0.1409 0.1993 1.3884 0.0394 1.0007 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 213: 92.2226 -5.8714 -2.1556 -4.2287 -0.9395 0.2255 0.0313 3.4460 1.0440 2.4800 0.1413 0.1993 1.3859 0.0397 1.0157 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 214: 92.2233 -5.8706 -2.1553 -4.2279 -0.9394 0.2237 0.0309 3.4283 1.0431 2.4809 0.1414 0.2003 1.3849 0.0399 1.0186 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 215: 92.2242 -5.8750 -2.1536 -4.2285 -0.9390 0.2212 0.0312 3.4442 1.0455 2.4800 0.1417 0.2015 1.3830 0.0401 1.0126 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 216: 92.2252 -5.8788 -2.1521 -4.2277 -0.9393 0.2192 0.0316 3.4718 1.0459 2.4791 0.1410 0.2028 1.3817 0.0402 1.0046 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 217: 92.2255 -5.8869 -2.1516 -4.2268 -0.9400 0.2177 0.0322 3.5295 1.0456 2.4751 0.1407 0.2042 1.3814 0.0401 1.0011 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 218: 92.2230 -5.8819 -2.1511 -4.2259 -0.9400 0.2164 0.0327 3.5004 1.0473 2.4693 0.1399 0.2051 1.3784 0.0401 0.9962 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 219: 92.2206 -5.8761 -2.1499 -4.2269 -0.9393 0.2156 0.0325 3.4736 1.0494 2.4667 0.1399 0.2066 1.3794 0.0399 0.9925 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 220: 92.2185 -5.8775 -2.1494 -4.2267 -0.9380 0.2150 0.0331 3.4894 1.0511 2.4596 0.1396 0.2090 1.3788 0.0398 0.9881 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 221: 92.2180 -5.8774 -2.1499 -4.2271 -0.9369 0.2142 0.0328 3.4873 1.0518 2.4559 0.1399 0.2109 1.3776 0.0399 0.9842 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 222: 92.2191 -5.8833 -2.1503 -4.2280 -0.9359 0.2127 0.0328 3.5384 1.0518 2.4533 0.1400 0.2114 1.3778 0.0400 0.9825 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 223: 92.2199 -5.8831 -2.1486 -4.2288 -0.9343 0.2112 0.0326 3.5474 1.0539 2.4515 0.1396 0.2127 1.3795 0.0398 0.9806 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 224: 92.2206 -5.8870 -2.1467 -4.2283 -0.9331 0.2093 0.0324 3.5619 1.0550 2.4482 0.1395 0.2133 1.3805 0.0395 0.9792 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 225: 92.2218 -5.8929 -2.1459 -4.2289 -0.9328 0.2086 0.0322 3.6001 1.0548 2.4492 0.1388 0.2142 1.3804 0.0393 0.9809 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 226: 92.2228 -5.8909 -2.1440 -4.2293 -0.9322 0.2082 0.0320 3.6007 1.0566 2.4513 0.1383 0.2143 1.3826 0.0390 0.9815 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 227: 92.2234 -5.8838 -2.1444 -4.2304 -0.9319 0.2088 0.0319 3.5748 1.0551 2.4562 0.1381 0.2140 1.3814 0.0390 0.9836 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 228: 92.2243 -5.8835 -2.1444 -4.2314 -0.9326 0.2093 0.0317 3.5756 1.0526 2.4607 0.1377 0.2143 1.3824 0.0389 0.9901 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 229: 92.2251 -5.8916 -2.1442 -4.2307 -0.9330 0.2095 0.0318 3.6344 1.0501 2.4580 0.1371 0.2148 1.3850 0.0388 0.9930 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 230: 92.2250 -5.8951 -2.1442 -4.2303 -0.9334 0.2107 0.0318 3.6533 1.0475 2.4550 0.1369 0.2150 1.3872 0.0387 0.9953 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 231: 92.2247 -5.8964 -2.1444 -4.2300 -0.9345 0.2119 0.0322 3.6564 1.0446 2.4549 0.1368 0.2151 1.3899 0.0388 0.9991 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 232: 92.2230 -5.8982 -2.1451 -4.2306 -0.9352 0.2132 0.0326 3.6643 1.0422 2.4591 0.1365 0.2155 1.3934 0.0388 1.0052 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 233: 92.2223 -5.9022 -2.1455 -4.2327 -0.9354 0.2141 0.0329 3.6824 1.0396 2.4697 0.1362 0.2165 1.3970 0.0388 1.0107 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 234: 92.2200 -5.9075 -2.1457 -4.2324 -0.9348 0.2140 0.0335 3.7056 1.0364 2.4735 0.1366 0.2174 1.3977 0.0388 1.0163 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 235: 92.2171 -5.9094 -2.1457 -4.2338 -0.9342 0.2142 0.0342 3.7222 1.0339 2.4854 0.1372 0.2189 1.3999 0.0389 1.0228 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 236: 92.2161 -5.9195 -2.1464 -4.2368 -0.9340 0.2140 0.0346 3.7789 1.0329 2.4986 0.1376 0.2200 1.4007 0.0389 1.0281 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 237: 92.2163 -5.9214 -2.1469 -4.2390 -0.9330 0.2143 0.0347 3.7862 1.0329 2.5074 0.1378 0.2195 1.4030 0.0389 1.0320 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 238: 92.2165 -5.9203 -2.1473 -4.2399 -0.9326 0.2143 0.0347 3.7781 1.0336 2.5100 0.1381 0.2186 1.4031 0.0388 1.0347 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 239: 92.2173 -5.9212 -2.1471 -4.2403 -0.9325 0.2136 0.0344 3.7908 1.0350 2.5128 0.1384 0.2175 1.4021 0.0389 1.0352 0.0718</span> +<span class="r-out co"><span class="r-pr">#></span> 240: 92.2178 -5.9217 -2.1470 -4.2394 -0.9322 0.2133 0.0342 3.8082 1.0363 2.5118 0.1384 0.2169 1.4025 0.0387 1.0345 0.0719</span> +<span class="r-out co"><span class="r-pr">#></span> 241: 92.2177 -5.9200 -2.1470 -4.2383 -0.9318 0.2136 0.0340 3.8123 1.0381 2.5110 0.1385 0.2161 1.4028 0.0387 1.0336 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 242: 92.2170 -5.9109 -2.1478 -4.2371 -0.9308 0.2136 0.0340 3.7766 1.0387 2.5090 0.1385 0.2157 1.4027 0.0386 1.0322 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 243: 92.2165 -5.9029 -2.1484 -4.2371 -0.9300 0.2140 0.0340 3.7433 1.0389 2.5128 0.1386 0.2150 1.4032 0.0385 1.0342 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 244: 92.2161 -5.8998 -2.1489 -4.2374 -0.9294 0.2143 0.0340 3.7242 1.0392 2.5173 0.1386 0.2148 1.4030 0.0384 1.0343 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 245: 92.2153 -5.9048 -2.1494 -4.2370 -0.9291 0.2149 0.0339 3.7491 1.0399 2.5182 0.1386 0.2146 1.4019 0.0383 1.0317 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 246: 92.2147 -5.9093 -2.1498 -4.2371 -0.9289 0.2156 0.0339 3.7727 1.0409 2.5218 0.1384 0.2145 1.4016 0.0382 1.0309 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 247: 92.2143 -5.9124 -2.1503 -4.2368 -0.9286 0.2159 0.0338 3.7972 1.0408 2.5232 0.1383 0.2144 1.4012 0.0382 1.0297 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 248: 92.2137 -5.9122 -2.1500 -4.2367 -0.9286 0.2160 0.0336 3.8036 1.0409 2.5245 0.1382 0.2141 1.4022 0.0381 1.0272 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 249: 92.2133 -5.9101 -2.1501 -4.2364 -0.9288 0.2160 0.0334 3.7984 1.0406 2.5268 0.1383 0.2136 1.4031 0.0381 1.0273 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 250: 92.2139 -5.9115 -2.1502 -4.2368 -0.9289 0.2167 0.0335 3.8015 1.0412 2.5326 0.1380 0.2132 1.4035 0.0381 1.0261 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 251: 92.2132 -5.9123 -2.1502 -4.2373 -0.9297 0.2170 0.0338 3.8015 1.0421 2.5362 0.1376 0.2126 1.4053 0.0379 1.0274 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 252: 92.2128 -5.9106 -2.1502 -4.2366 -0.9299 0.2174 0.0338 3.7931 1.0427 2.5345 0.1371 0.2120 1.4062 0.0379 1.0262 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 253: 92.2118 -5.9098 -2.1492 -4.2364 -0.9297 0.2173 0.0340 3.8011 1.0420 2.5338 0.1369 0.2121 1.4074 0.0378 1.0232 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 254: 92.2107 -5.9104 -2.1479 -4.2362 -0.9296 0.2171 0.0341 3.8085 1.0398 2.5330 0.1366 0.2123 1.4093 0.0377 1.0230 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 255: 92.2103 -5.9133 -2.1466 -4.2359 -0.9299 0.2166 0.0341 3.8219 1.0381 2.5346 0.1363 0.2122 1.4105 0.0377 1.0230 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 256: 92.2094 -5.9171 -2.1453 -4.2356 -0.9299 0.2161 0.0341 3.8498 1.0366 2.5366 0.1362 0.2123 1.4114 0.0375 1.0239 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 257: 92.2091 -5.9169 -2.1441 -4.2353 -0.9302 0.2153 0.0341 3.8529 1.0347 2.5385 0.1360 0.2118 1.4126 0.0375 1.0265 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 258: 92.2089 -5.9191 -2.1431 -4.2349 -0.9301 0.2145 0.0340 3.8608 1.0331 2.5392 0.1359 0.2119 1.4126 0.0375 1.0282 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 259: 92.2093 -5.9249 -2.1426 -4.2337 -0.9301 0.2145 0.0341 3.8853 1.0321 2.5385 0.1361 0.2120 1.4114 0.0374 1.0280 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 260: 92.2095 -5.9297 -2.1415 -4.2328 -0.9303 0.2146 0.0339 3.9108 1.0302 2.5367 0.1358 0.2125 1.4112 0.0373 1.0265 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 261: 92.2096 -5.9341 -2.1407 -4.2321 -0.9307 0.2147 0.0338 3.9343 1.0278 2.5343 0.1356 0.2131 1.4121 0.0373 1.0272 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 262: 92.2094 -5.9342 -2.1398 -4.2312 -0.9310 0.2149 0.0336 3.9314 1.0254 2.5313 0.1356 0.2139 1.4115 0.0372 1.0249 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 263: 92.2088 -5.9376 -2.1388 -4.2304 -0.9313 0.2153 0.0334 3.9452 1.0232 2.5289 0.1357 0.2143 1.4109 0.0371 1.0228 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 264: 92.2077 -5.9410 -2.1379 -4.2301 -0.9317 0.2153 0.0333 3.9571 1.0204 2.5265 0.1356 0.2147 1.4105 0.0371 1.0224 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 265: 92.2069 -5.9454 -2.1374 -4.2296 -0.9322 0.2154 0.0332 3.9800 1.0182 2.5230 0.1356 0.2147 1.4115 0.0371 1.0232 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 266: 92.2067 -5.9463 -2.1370 -4.2291 -0.9324 0.2155 0.0330 3.9809 1.0165 2.5217 0.1354 0.2148 1.4121 0.0371 1.0220 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 267: 92.2064 -5.9492 -2.1368 -4.2282 -0.9329 0.2154 0.0328 3.9874 1.0150 2.5199 0.1357 0.2150 1.4124 0.0370 1.0233 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 268: 92.2065 -5.9468 -2.1360 -4.2276 -0.9333 0.2155 0.0328 3.9722 1.0133 2.5171 0.1362 0.2155 1.4133 0.0369 1.0243 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 269: 92.2066 -5.9438 -2.1352 -4.2267 -0.9335 0.2151 0.0328 3.9526 1.0122 2.5142 0.1367 0.2154 1.4140 0.0369 1.0244 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 270: 92.2067 -5.9388 -2.1351 -4.2259 -0.9339 0.2151 0.0326 3.9283 1.0112 2.5114 0.1370 0.2157 1.4137 0.0368 1.0240 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 271: 92.2069 -5.9350 -2.1344 -4.2252 -0.9342 0.2152 0.0324 3.9072 1.0107 2.5094 0.1370 0.2158 1.4136 0.0367 1.0222 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 272: 92.2069 -5.9317 -2.1341 -4.2246 -0.9348 0.2153 0.0321 3.8870 1.0104 2.5082 0.1372 0.2157 1.4139 0.0366 1.0219 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 273: 92.2068 -5.9289 -2.1340 -4.2240 -0.9348 0.2152 0.0320 3.8711 1.0101 2.5075 0.1373 0.2159 1.4146 0.0366 1.0232 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 274: 92.2067 -5.9271 -2.1337 -4.2239 -0.9350 0.2153 0.0318 3.8569 1.0101 2.5085 0.1377 0.2157 1.4144 0.0366 1.0239 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 275: 92.2063 -5.9264 -2.1339 -4.2235 -0.9353 0.2156 0.0317 3.8476 1.0097 2.5078 0.1382 0.2157 1.4143 0.0365 1.0256 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 276: 92.2059 -5.9271 -2.1339 -4.2231 -0.9354 0.2160 0.0316 3.8417 1.0097 2.5074 0.1387 0.2156 1.4132 0.0365 1.0260 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 277: 92.2059 -5.9283 -2.1342 -4.2225 -0.9356 0.2163 0.0316 3.8412 1.0094 2.5073 0.1393 0.2155 1.4122 0.0364 1.0283 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 278: 92.2062 -5.9278 -2.1341 -4.2220 -0.9361 0.2166 0.0318 3.8331 1.0081 2.5069 0.1397 0.2154 1.4117 0.0364 1.0321 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 279: 92.2061 -5.9264 -2.1341 -4.2214 -0.9363 0.2168 0.0319 3.8188 1.0072 2.5051 0.1402 0.2155 1.4111 0.0364 1.0342 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 280: 92.2057 -5.9263 -2.1344 -4.2211 -0.9365 0.2167 0.0321 3.8114 1.0072 2.5061 0.1406 0.2148 1.4108 0.0365 1.0361 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 281: 92.2048 -5.9269 -2.1344 -4.2208 -0.9365 0.2166 0.0324 3.8082 1.0076 2.5077 0.1410 0.2142 1.4098 0.0365 1.0363 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 282: 92.2045 -5.9257 -2.1347 -4.2205 -0.9366 0.2165 0.0328 3.8040 1.0082 2.5092 0.1413 0.2138 1.4090 0.0365 1.0364 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 283: 92.2038 -5.9235 -2.1348 -4.2201 -0.9363 0.2163 0.0331 3.7955 1.0089 2.5108 0.1415 0.2134 1.4086 0.0365 1.0362 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 284: 92.2032 -5.9234 -2.1348 -4.2198 -0.9359 0.2162 0.0335 3.7945 1.0100 2.5118 0.1420 0.2129 1.4083 0.0365 1.0362 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 285: 92.2028 -5.9236 -2.1347 -4.2193 -0.9360 0.2161 0.0339 3.7930 1.0104 2.5124 0.1422 0.2125 1.4080 0.0365 1.0373 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 286: 92.2020 -5.9221 -2.1344 -4.2187 -0.9355 0.2156 0.0341 3.7872 1.0104 2.5134 0.1425 0.2121 1.4074 0.0364 1.0377 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 287: 92.2013 -5.9213 -2.1341 -4.2183 -0.9354 0.2154 0.0343 3.7888 1.0098 2.5151 0.1428 0.2119 1.4075 0.0364 1.0390 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 288: 92.2003 -5.9195 -2.1339 -4.2182 -0.9355 0.2152 0.0343 3.7831 1.0090 2.5180 0.1430 0.2116 1.4082 0.0364 1.0408 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 289: 92.1995 -5.9186 -2.1339 -4.2182 -0.9355 0.2154 0.0343 3.7805 1.0083 2.5217 0.1429 0.2115 1.4085 0.0364 1.0426 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 290: 92.1984 -5.9180 -2.1339 -4.2177 -0.9354 0.2153 0.0343 3.7767 1.0080 2.5219 0.1427 0.2113 1.4083 0.0365 1.0429 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 291: 92.1975 -5.9167 -2.1334 -4.2175 -0.9355 0.2151 0.0343 3.7701 1.0080 2.5230 0.1427 0.2108 1.4083 0.0364 1.0439 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 292: 92.1971 -5.9175 -2.1330 -4.2166 -0.9356 0.2144 0.0342 3.7722 1.0081 2.5227 0.1426 0.2107 1.4079 0.0364 1.0443 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 293: 92.1963 -5.9188 -2.1330 -4.2157 -0.9357 0.2141 0.0342 3.7768 1.0083 2.5242 0.1425 0.2103 1.4073 0.0364 1.0439 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 294: 92.1953 -5.9189 -2.1328 -4.2157 -0.9357 0.2136 0.0344 3.7727 1.0078 2.5294 0.1427 0.2095 1.4079 0.0364 1.0456 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 295: 92.1946 -5.9171 -2.1329 -4.2153 -0.9355 0.2135 0.0345 3.7623 1.0081 2.5331 0.1426 0.2090 1.4080 0.0364 1.0462 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 296: 92.1940 -5.9154 -2.1329 -4.2150 -0.9354 0.2130 0.0346 3.7523 1.0082 2.5354 0.1425 0.2084 1.4075 0.0365 1.0463 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 297: 92.1934 -5.9128 -2.1330 -4.2145 -0.9351 0.2127 0.0349 3.7395 1.0084 2.5373 0.1423 0.2079 1.4072 0.0365 1.0453 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 298: 92.1932 -5.9128 -2.1332 -4.2138 -0.9347 0.2120 0.0350 3.7372 1.0085 2.5368 0.1423 0.2075 1.4068 0.0365 1.0449 0.0720</span> +<span class="r-out co"><span class="r-pr">#></span> 299: 92.1927 -5.9120 -2.1333 -4.2131 -0.9344 0.2112 0.0352 3.7324 1.0088 2.5366 0.1422 0.2070 1.4059 0.0366 1.0441 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 300: 92.1921 -5.9097 -2.1335 -4.2122 -0.9343 0.2105 0.0353 3.7211 1.0096 2.5357 0.1425 0.2066 1.4050 0.0367 1.0443 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 301: 92.1915 -5.9081 -2.1337 -4.2116 -0.9343 0.2098 0.0355 3.7110 1.0104 2.5355 0.1427 0.2061 1.4041 0.0368 1.0448 0.0721</span> +<span class="r-out co"><span class="r-pr">#></span> 302: 92.1912 -5.9067 -2.1340 -4.2108 -0.9342 0.2092 0.0355 3.7052 1.0114 2.5348 0.1428 0.2055 1.4036 0.0369 1.0442 0.0722</span> +<span class="r-out co"><span class="r-pr">#></span> 303: 92.1913 -5.9039 -2.1342 -4.2113 -0.9342 0.2087 0.0355 3.6925 1.0123 2.5408 0.1430 0.2049 1.4028 0.0369 1.0436 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 304: 92.1920 -5.9012 -2.1342 -4.2119 -0.9342 0.2081 0.0356 3.6781 1.0129 2.5476 0.1432 0.2044 1.4026 0.0369 1.0436 0.0723</span> +<span class="r-out co"><span class="r-pr">#></span> 305: 92.1923 -5.8984 -2.1343 -4.2123 -0.9341 0.2076 0.0354 3.6633 1.0134 2.5525 0.1434 0.2038 1.4022 0.0370 1.0434 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 306: 92.1926 -5.8977 -2.1343 -4.2121 -0.9343 0.2072 0.0354 3.6603 1.0144 2.5567 0.1436 0.2030 1.4022 0.0369 1.0431 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 307: 92.1931 -5.8970 -2.1346 -4.2124 -0.9344 0.2068 0.0353 3.6555 1.0154 2.5617 0.1438 0.2021 1.4017 0.0370 1.0431 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 308: 92.1935 -5.8963 -2.1347 -4.2127 -0.9343 0.2062 0.0351 3.6486 1.0166 2.5665 0.1439 0.2012 1.4017 0.0370 1.0431 0.0724</span> +<span class="r-out co"><span class="r-pr">#></span> 309: 92.1934 -5.8965 -2.1349 -4.2130 -0.9344 0.2058 0.0350 3.6454 1.0180 2.5711 0.1439 0.2003 1.4013 0.0370 1.0427 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 310: 92.1935 -5.8965 -2.1349 -4.2133 -0.9345 0.2055 0.0350 3.6401 1.0193 2.5761 0.1439 0.1993 1.4013 0.0371 1.0418 0.0725</span> +<span class="r-out co"><span class="r-pr">#></span> 311: 92.1931 -5.8976 -2.1349 -4.2139 -0.9346 0.2052 0.0349 3.6416 1.0207 2.5820 0.1437 0.1982 1.4015 0.0370 1.0411 0.0726</span> +<span class="r-out co"><span class="r-pr">#></span> 312: 92.1928 -5.8995 -2.1350 -4.2149 -0.9349 0.2053 0.0350 3.6472 1.0222 2.5902 0.1437 0.1972 1.4018 0.0370 1.0412 0.0727</span> +<span class="r-out co"><span class="r-pr">#></span> 313: 92.1922 -5.8999 -2.1350 -4.2159 -0.9352 0.2055 0.0350 3.6450 1.0236 2.5989 0.1436 0.1962 1.4017 0.0369 1.0407 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 314: 92.1913 -5.9021 -2.1353 -4.2171 -0.9353 0.2055 0.0350 3.6532 1.0244 2.6086 0.1437 0.1951 1.4019 0.0369 1.0409 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 315: 92.1905 -5.9033 -2.1358 -4.2178 -0.9354 0.2055 0.0351 3.6591 1.0252 2.6142 0.1438 0.1941 1.4018 0.0369 1.0420 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 316: 92.1895 -5.9043 -2.1358 -4.2186 -0.9352 0.2053 0.0352 3.6648 1.0266 2.6207 0.1441 0.1934 1.4016 0.0369 1.0420 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 317: 92.1888 -5.9041 -2.1359 -4.2200 -0.9352 0.2052 0.0352 3.6673 1.0278 2.6312 0.1444 0.1926 1.4014 0.0369 1.0416 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 318: 92.1879 -5.9039 -2.1360 -4.2212 -0.9352 0.2052 0.0354 3.6670 1.0292 2.6380 0.1446 0.1919 1.4010 0.0369 1.0403 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 319: 92.1871 -5.9046 -2.1361 -4.2222 -0.9353 0.2052 0.0354 3.6709 1.0306 2.6432 0.1448 0.1912 1.4008 0.0369 1.0394 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 320: 92.1863 -5.9023 -2.1365 -4.2229 -0.9355 0.2052 0.0355 3.6602 1.0318 2.6466 0.1448 0.1903 1.4011 0.0369 1.0398 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 321: 92.1855 -5.8996 -2.1368 -4.2236 -0.9354 0.2053 0.0355 3.6491 1.0329 2.6505 0.1448 0.1895 1.4017 0.0369 1.0402 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 322: 92.1850 -5.8979 -2.1370 -4.2243 -0.9353 0.2057 0.0356 3.6399 1.0341 2.6534 0.1447 0.1888 1.4020 0.0368 1.0394 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 323: 92.1844 -5.8984 -2.1371 -4.2251 -0.9352 0.2059 0.0356 3.6431 1.0346 2.6566 0.1447 0.1882 1.4026 0.0368 1.0389 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 324: 92.1838 -5.8967 -2.1372 -4.2257 -0.9353 0.2062 0.0356 3.6392 1.0351 2.6598 0.1445 0.1875 1.4031 0.0368 1.0382 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 325: 92.1835 -5.8936 -2.1374 -4.2264 -0.9351 0.2066 0.0355 3.6288 1.0352 2.6633 0.1444 0.1869 1.4043 0.0367 1.0391 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 326: 92.1837 -5.8936 -2.1376 -4.2276 -0.9350 0.2071 0.0354 3.6296 1.0354 2.6684 0.1444 0.1865 1.4043 0.0367 1.0380 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 327: 92.1837 -5.8943 -2.1378 -4.2289 -0.9347 0.2076 0.0354 3.6348 1.0357 2.6746 0.1444 0.1860 1.4043 0.0366 1.0380 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 328: 92.1838 -5.8953 -2.1380 -4.2297 -0.9345 0.2081 0.0354 3.6456 1.0360 2.6776 0.1444 0.1856 1.4043 0.0366 1.0379 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 329: 92.1836 -5.8974 -2.1383 -4.2305 -0.9342 0.2085 0.0356 3.6591 1.0361 2.6802 0.1444 0.1852 1.4043 0.0366 1.0385 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 330: 92.1832 -5.8994 -2.1387 -4.2305 -0.9342 0.2088 0.0358 3.6715 1.0364 2.6798 0.1443 0.1849 1.4037 0.0367 1.0378 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 331: 92.1826 -5.8983 -2.1391 -4.2302 -0.9342 0.2091 0.0357 3.6670 1.0368 2.6800 0.1442 0.1845 1.4038 0.0367 1.0379 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 332: 92.1824 -5.8959 -2.1396 -4.2301 -0.9341 0.2097 0.0357 3.6576 1.0375 2.6792 0.1442 0.1842 1.4034 0.0367 1.0372 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 333: 92.1826 -5.8937 -2.1401 -4.2304 -0.9340 0.2104 0.0356 3.6487 1.0383 2.6798 0.1442 0.1838 1.4029 0.0367 1.0360 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 334: 92.1825 -5.8911 -2.1407 -4.2311 -0.9339 0.2112 0.0355 3.6378 1.0390 2.6825 0.1444 0.1834 1.4025 0.0367 1.0349 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 335: 92.1830 -5.8887 -2.1411 -4.2317 -0.9336 0.2118 0.0355 3.6294 1.0396 2.6850 0.1444 0.1830 1.4022 0.0367 1.0338 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 336: 92.1834 -5.8872 -2.1413 -4.2324 -0.9334 0.2124 0.0356 3.6249 1.0402 2.6880 0.1444 0.1825 1.4024 0.0367 1.0339 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 337: 92.1835 -5.8869 -2.1416 -4.2334 -0.9332 0.2131 0.0356 3.6252 1.0411 2.6926 0.1443 0.1821 1.4029 0.0366 1.0330 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 338: 92.1839 -5.8882 -2.1418 -4.2346 -0.9333 0.2137 0.0357 3.6332 1.0421 2.6972 0.1441 0.1815 1.4036 0.0366 1.0324 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 339: 92.1845 -5.8869 -2.1420 -4.2358 -0.9332 0.2143 0.0357 3.6261 1.0428 2.7021 0.1439 0.1810 1.4043 0.0366 1.0322 0.0742</span> +<span class="r-out co"><span class="r-pr">#></span> 340: 92.1846 -5.8863 -2.1421 -4.2367 -0.9331 0.2147 0.0357 3.6242 1.0436 2.7060 0.1439 0.1804 1.4049 0.0365 1.0328 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 341: 92.1848 -5.8847 -2.1421 -4.2378 -0.9330 0.2150 0.0356 3.6177 1.0442 2.7099 0.1439 0.1798 1.4056 0.0366 1.0334 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 342: 92.1848 -5.8838 -2.1421 -4.2390 -0.9330 0.2154 0.0355 3.6114 1.0449 2.7151 0.1438 0.1792 1.4064 0.0365 1.0332 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 343: 92.1849 -5.8840 -2.1423 -4.2398 -0.9330 0.2157 0.0353 3.6109 1.0459 2.7191 0.1438 0.1785 1.4060 0.0366 1.0334 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 344: 92.1851 -5.8839 -2.1423 -4.2406 -0.9330 0.2159 0.0352 3.6092 1.0467 2.7229 0.1440 0.1779 1.4060 0.0365 1.0338 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 345: 92.1850 -5.8841 -2.1424 -4.2414 -0.9331 0.2162 0.0352 3.6070 1.0472 2.7263 0.1441 0.1774 1.4056 0.0365 1.0341 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 346: 92.1848 -5.8839 -2.1424 -4.2420 -0.9333 0.2164 0.0352 3.6048 1.0479 2.7292 0.1443 0.1769 1.4058 0.0365 1.0344 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 347: 92.1846 -5.8835 -2.1425 -4.2427 -0.9334 0.2166 0.0353 3.6017 1.0495 2.7330 0.1444 0.1763 1.4053 0.0365 1.0343 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 348: 92.1846 -5.8825 -2.1427 -4.2434 -0.9336 0.2168 0.0353 3.5968 1.0508 2.7362 0.1445 0.1757 1.4051 0.0365 1.0343 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 349: 92.1846 -5.8820 -2.1432 -4.2444 -0.9337 0.2172 0.0352 3.5937 1.0519 2.7412 0.1446 0.1752 1.4047 0.0365 1.0343 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 350: 92.1845 -5.8817 -2.1435 -4.2454 -0.9338 0.2179 0.0351 3.5899 1.0526 2.7460 0.1448 0.1747 1.4042 0.0365 1.0339 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 351: 92.1844 -5.8824 -2.1439 -4.2468 -0.9338 0.2184 0.0350 3.5917 1.0535 2.7531 0.1448 0.1740 1.4041 0.0365 1.0336 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 352: 92.1840 -5.8840 -2.1442 -4.2482 -0.9338 0.2189 0.0350 3.6013 1.0543 2.7603 0.1450 0.1734 1.4044 0.0364 1.0342 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 353: 92.1838 -5.8848 -2.1445 -4.2492 -0.9336 0.2194 0.0349 3.6030 1.0552 2.7652 0.1451 0.1730 1.4043 0.0364 1.0338 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 354: 92.1838 -5.8835 -2.1449 -4.2501 -0.9336 0.2197 0.0349 3.5961 1.0563 2.7697 0.1452 0.1723 1.4044 0.0364 1.0342 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 355: 92.1837 -5.8826 -2.1453 -4.2511 -0.9335 0.2199 0.0348 3.5910 1.0569 2.7757 0.1451 0.1718 1.4053 0.0364 1.0348 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 356: 92.1835 -5.8826 -2.1456 -4.2520 -0.9334 0.2198 0.0348 3.5922 1.0577 2.7815 0.1451 0.1712 1.4054 0.0364 1.0352 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 357: 92.1834 -5.8818 -2.1457 -4.2525 -0.9334 0.2198 0.0349 3.5894 1.0588 2.7852 0.1449 0.1706 1.4058 0.0364 1.0354 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 358: 92.1834 -5.8808 -2.1459 -4.2531 -0.9334 0.2197 0.0348 3.5861 1.0600 2.7891 0.1449 0.1701 1.4062 0.0364 1.0361 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 359: 92.1833 -5.8799 -2.1459 -4.2533 -0.9333 0.2197 0.0350 3.5822 1.0607 2.7903 0.1448 0.1696 1.4063 0.0364 1.0360 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 360: 92.1831 -5.8792 -2.1460 -4.2534 -0.9332 0.2196 0.0351 3.5787 1.0613 2.7914 0.1446 0.1691 1.4065 0.0364 1.0361 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 361: 92.1831 -5.8785 -2.1460 -4.2542 -0.9331 0.2196 0.0351 3.5771 1.0620 2.7969 0.1445 0.1688 1.4072 0.0364 1.0366 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 362: 92.1832 -5.8780 -2.1462 -4.2547 -0.9331 0.2195 0.0351 3.5750 1.0625 2.8017 0.1443 0.1683 1.4079 0.0363 1.0369 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 363: 92.1830 -5.8788 -2.1464 -4.2551 -0.9331 0.2192 0.0351 3.5785 1.0630 2.8057 0.1443 0.1677 1.4081 0.0363 1.0377 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 364: 92.1829 -5.8778 -2.1466 -4.2554 -0.9332 0.2193 0.0350 3.5747 1.0634 2.8092 0.1443 0.1672 1.4084 0.0363 1.0386 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 365: 92.1830 -5.8782 -2.1466 -4.2558 -0.9332 0.2192 0.0350 3.5771 1.0638 2.8135 0.1443 0.1667 1.4086 0.0363 1.0385 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 366: 92.1830 -5.8795 -2.1465 -4.2564 -0.9332 0.2190 0.0350 3.5838 1.0645 2.8190 0.1444 0.1661 1.4086 0.0363 1.0390 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 367: 92.1826 -5.8801 -2.1465 -4.2569 -0.9333 0.2191 0.0349 3.5867 1.0652 2.8232 0.1445 0.1657 1.4086 0.0362 1.0388 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 368: 92.1824 -5.8799 -2.1465 -4.2571 -0.9333 0.2193 0.0348 3.5859 1.0654 2.8252 0.1445 0.1653 1.4088 0.0362 1.0385 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 369: 92.1822 -5.8803 -2.1467 -4.2572 -0.9333 0.2193 0.0348 3.5846 1.0653 2.8261 0.1444 0.1648 1.4086 0.0362 1.0393 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 370: 92.1820 -5.8802 -2.1469 -4.2575 -0.9333 0.2195 0.0348 3.5822 1.0653 2.8273 0.1444 0.1645 1.4088 0.0362 1.0396 0.0744</span> +<span class="r-out co"><span class="r-pr">#></span> 371: 92.1818 -5.8806 -2.1470 -4.2575 -0.9333 0.2198 0.0348 3.5819 1.0649 2.8277 0.1443 0.1642 1.4091 0.0362 1.0403 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 372: 92.1818 -5.8804 -2.1473 -4.2580 -0.9332 0.2202 0.0348 3.5795 1.0645 2.8300 0.1441 0.1640 1.4096 0.0362 1.0418 0.0743</span> +<span class="r-out co"><span class="r-pr">#></span> 373: 92.1816 -5.8812 -2.1475 -4.2580 -0.9332 0.2203 0.0348 3.5816 1.0644 2.8298 0.1441 0.1639 1.4100 0.0362 1.0439 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 374: 92.1815 -5.8817 -2.1477 -4.2578 -0.9333 0.2203 0.0349 3.5819 1.0641 2.8282 0.1440 0.1641 1.4099 0.0362 1.0443 0.0741</span> +<span class="r-out co"><span class="r-pr">#></span> 375: 92.1817 -5.8828 -2.1479 -4.2574 -0.9335 0.2204 0.0351 3.5853 1.0636 2.8267 0.1440 0.1642 1.4100 0.0362 1.0457 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 376: 92.1819 -5.8826 -2.1479 -4.2573 -0.9338 0.2206 0.0353 3.5843 1.0634 2.8246 0.1440 0.1643 1.4100 0.0362 1.0464 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 377: 92.1819 -5.8826 -2.1480 -4.2572 -0.9339 0.2206 0.0354 3.5819 1.0633 2.8225 0.1440 0.1644 1.4097 0.0363 1.0470 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 378: 92.1819 -5.8821 -2.1481 -4.2571 -0.9340 0.2205 0.0355 3.5777 1.0633 2.8206 0.1440 0.1644 1.4093 0.0363 1.0468 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 379: 92.1819 -5.8823 -2.1481 -4.2573 -0.9340 0.2205 0.0356 3.5746 1.0633 2.8201 0.1439 0.1645 1.4092 0.0363 1.0468 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 380: 92.1820 -5.8809 -2.1481 -4.2570 -0.9340 0.2205 0.0356 3.5665 1.0634 2.8178 0.1439 0.1647 1.4093 0.0363 1.0463 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 381: 92.1823 -5.8795 -2.1481 -4.2568 -0.9338 0.2204 0.0357 3.5586 1.0635 2.8170 0.1439 0.1648 1.4095 0.0363 1.0456 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 382: 92.1828 -5.8783 -2.1481 -4.2571 -0.9339 0.2203 0.0357 3.5514 1.0636 2.8183 0.1441 0.1649 1.4093 0.0363 1.0462 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 383: 92.1827 -5.8773 -2.1480 -4.2569 -0.9340 0.2202 0.0357 3.5459 1.0633 2.8173 0.1441 0.1650 1.4094 0.0363 1.0465 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 384: 92.1825 -5.8763 -2.1482 -4.2568 -0.9341 0.2202 0.0357 3.5397 1.0636 2.8165 0.1441 0.1650 1.4094 0.0363 1.0467 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 385: 92.1822 -5.8761 -2.1483 -4.2567 -0.9341 0.2201 0.0357 3.5363 1.0641 2.8160 0.1440 0.1650 1.4094 0.0363 1.0469 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 386: 92.1820 -5.8763 -2.1485 -4.2567 -0.9342 0.2200 0.0356 3.5365 1.0645 2.8157 0.1441 0.1648 1.4092 0.0364 1.0478 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 387: 92.1819 -5.8767 -2.1486 -4.2567 -0.9343 0.2201 0.0358 3.5383 1.0652 2.8156 0.1442 0.1646 1.4090 0.0364 1.0480 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 388: 92.1818 -5.8772 -2.1488 -4.2569 -0.9344 0.2202 0.0359 3.5400 1.0656 2.8153 0.1443 0.1645 1.4086 0.0364 1.0480 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 389: 92.1816 -5.8765 -2.1489 -4.2569 -0.9344 0.2203 0.0359 3.5369 1.0660 2.8145 0.1443 0.1644 1.4083 0.0364 1.0476 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 390: 92.1815 -5.8761 -2.1490 -4.2569 -0.9343 0.2205 0.0359 3.5349 1.0664 2.8136 0.1444 0.1644 1.4080 0.0364 1.0472 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 391: 92.1814 -5.8749 -2.1492 -4.2572 -0.9343 0.2207 0.0359 3.5313 1.0668 2.8153 0.1445 0.1643 1.4077 0.0364 1.0465 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 392: 92.1812 -5.8733 -2.1494 -4.2571 -0.9344 0.2210 0.0359 3.5248 1.0674 2.8141 0.1445 0.1642 1.4073 0.0364 1.0457 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 393: 92.1811 -5.8727 -2.1497 -4.2570 -0.9345 0.2212 0.0359 3.5226 1.0679 2.8127 0.1445 0.1642 1.4071 0.0364 1.0457 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 394: 92.1811 -5.8712 -2.1500 -4.2572 -0.9346 0.2214 0.0360 3.5174 1.0684 2.8132 0.1446 0.1641 1.4067 0.0364 1.0456 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 395: 92.1810 -5.8714 -2.1501 -4.2579 -0.9348 0.2217 0.0361 3.5182 1.0685 2.8171 0.1445 0.1641 1.4065 0.0364 1.0452 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 396: 92.1809 -5.8711 -2.1501 -4.2582 -0.9350 0.2220 0.0363 3.5161 1.0681 2.8184 0.1446 0.1639 1.4063 0.0364 1.0447 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 397: 92.1809 -5.8707 -2.1503 -4.2585 -0.9352 0.2222 0.0363 3.5119 1.0684 2.8197 0.1446 0.1637 1.4065 0.0364 1.0442 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 398: 92.1808 -5.8703 -2.1503 -4.2591 -0.9354 0.2224 0.0363 3.5084 1.0689 2.8218 0.1447 0.1634 1.4064 0.0364 1.0445 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 399: 92.1806 -5.8711 -2.1503 -4.2596 -0.9355 0.2226 0.0364 3.5114 1.0691 2.8234 0.1447 0.1629 1.4061 0.0364 1.0447 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 400: 92.1806 -5.8713 -2.1503 -4.2601 -0.9356 0.2229 0.0366 3.5113 1.0695 2.8253 0.1448 0.1626 1.4059 0.0364 1.0440 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 401: 92.1804 -5.8709 -2.1503 -4.2604 -0.9357 0.2231 0.0367 3.5089 1.0696 2.8266 0.1448 0.1624 1.4058 0.0364 1.0440 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 402: 92.1801 -5.8705 -2.1502 -4.2606 -0.9358 0.2232 0.0368 3.5071 1.0695 2.8268 0.1447 0.1621 1.4060 0.0364 1.0447 0.0740</span> +<span class="r-out co"><span class="r-pr">#></span> 403: 92.1800 -5.8708 -2.1503 -4.2610 -0.9359 0.2234 0.0369 3.5083 1.0697 2.8271 0.1447 0.1618 1.4056 0.0365 1.0448 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 404: 92.1798 -5.8709 -2.1505 -4.2612 -0.9360 0.2237 0.0369 3.5085 1.0699 2.8262 0.1447 0.1616 1.4055 0.0365 1.0449 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 405: 92.1795 -5.8705 -2.1503 -4.2613 -0.9360 0.2239 0.0370 3.5059 1.0698 2.8254 0.1448 0.1615 1.4052 0.0364 1.0449 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 406: 92.1792 -5.8710 -2.1504 -4.2613 -0.9359 0.2243 0.0371 3.5069 1.0696 2.8244 0.1449 0.1614 1.4049 0.0364 1.0447 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 407: 92.1788 -5.8718 -2.1505 -4.2614 -0.9359 0.2243 0.0372 3.5092 1.0697 2.8234 0.1449 0.1614 1.4046 0.0364 1.0448 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 408: 92.1786 -5.8729 -2.1505 -4.2615 -0.9360 0.2245 0.0373 3.5140 1.0699 2.8223 0.1449 0.1612 1.4045 0.0365 1.0455 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 409: 92.1784 -5.8740 -2.1506 -4.2615 -0.9360 0.2246 0.0373 3.5192 1.0700 2.8213 0.1450 0.1610 1.4042 0.0365 1.0462 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 410: 92.1782 -5.8753 -2.1505 -4.2616 -0.9361 0.2246 0.0373 3.5248 1.0705 2.8205 0.1450 0.1607 1.4040 0.0365 1.0465 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 411: 92.1780 -5.8758 -2.1503 -4.2619 -0.9362 0.2247 0.0374 3.5249 1.0707 2.8204 0.1449 0.1605 1.4043 0.0364 1.0467 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 412: 92.1778 -5.8759 -2.1502 -4.2621 -0.9363 0.2248 0.0374 3.5238 1.0707 2.8209 0.1448 0.1602 1.4045 0.0364 1.0466 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 413: 92.1779 -5.8759 -2.1501 -4.2623 -0.9364 0.2249 0.0374 3.5225 1.0711 2.8213 0.1448 0.1600 1.4043 0.0364 1.0460 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 414: 92.1781 -5.8754 -2.1500 -4.2622 -0.9364 0.2250 0.0374 3.5205 1.0710 2.8203 0.1448 0.1599 1.4047 0.0364 1.0456 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 415: 92.1781 -5.8750 -2.1499 -4.2623 -0.9363 0.2251 0.0374 3.5187 1.0709 2.8190 0.1448 0.1598 1.4050 0.0364 1.0448 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 416: 92.1783 -5.8747 -2.1500 -4.2624 -0.9363 0.2252 0.0375 3.5216 1.0708 2.8187 0.1448 0.1598 1.4052 0.0364 1.0440 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 417: 92.1783 -5.8738 -2.1500 -4.2625 -0.9362 0.2252 0.0375 3.5219 1.0712 2.8188 0.1447 0.1597 1.4055 0.0364 1.0438 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 418: 92.1784 -5.8735 -2.1501 -4.2627 -0.9360 0.2254 0.0375 3.5222 1.0715 2.8193 0.1448 0.1596 1.4057 0.0364 1.0438 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 419: 92.1784 -5.8725 -2.1501 -4.2629 -0.9358 0.2255 0.0376 3.5190 1.0719 2.8202 0.1447 0.1594 1.4060 0.0364 1.0436 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 420: 92.1785 -5.8713 -2.1500 -4.2633 -0.9357 0.2256 0.0377 3.5152 1.0723 2.8213 0.1447 0.1592 1.4065 0.0364 1.0439 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 421: 92.1786 -5.8697 -2.1500 -4.2639 -0.9355 0.2257 0.0377 3.5100 1.0728 2.8232 0.1448 0.1592 1.4068 0.0364 1.0436 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 422: 92.1787 -5.8683 -2.1502 -4.2645 -0.9352 0.2260 0.0377 3.5051 1.0732 2.8258 0.1448 0.1592 1.4069 0.0364 1.0432 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 423: 92.1788 -5.8667 -2.1504 -4.2653 -0.9350 0.2262 0.0377 3.4992 1.0736 2.8292 0.1448 0.1592 1.4071 0.0364 1.0435 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 424: 92.1789 -5.8659 -2.1505 -4.2661 -0.9349 0.2263 0.0378 3.4972 1.0739 2.8324 0.1448 0.1591 1.4069 0.0364 1.0439 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 425: 92.1788 -5.8649 -2.1505 -4.2669 -0.9349 0.2263 0.0378 3.4947 1.0740 2.8358 0.1448 0.1590 1.4071 0.0364 1.0438 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 426: 92.1788 -5.8643 -2.1506 -4.2677 -0.9348 0.2265 0.0377 3.4922 1.0743 2.8389 0.1448 0.1589 1.4070 0.0365 1.0437 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 427: 92.1785 -5.8637 -2.1506 -4.2683 -0.9347 0.2266 0.0378 3.4895 1.0747 2.8425 0.1448 0.1588 1.4068 0.0365 1.0434 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 428: 92.1783 -5.8627 -2.1507 -4.2689 -0.9347 0.2268 0.0378 3.4870 1.0749 2.8464 0.1447 0.1586 1.4070 0.0365 1.0434 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 429: 92.1782 -5.8617 -2.1509 -4.2696 -0.9347 0.2271 0.0379 3.4845 1.0752 2.8500 0.1446 0.1584 1.4072 0.0365 1.0439 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 430: 92.1783 -5.8608 -2.1510 -4.2701 -0.9347 0.2274 0.0379 3.4830 1.0755 2.8526 0.1446 0.1582 1.4075 0.0365 1.0443 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 431: 92.1784 -5.8606 -2.1511 -4.2704 -0.9348 0.2275 0.0379 3.4825 1.0757 2.8532 0.1446 0.1580 1.4076 0.0365 1.0439 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 432: 92.1784 -5.8610 -2.1512 -4.2707 -0.9350 0.2275 0.0378 3.4833 1.0761 2.8539 0.1447 0.1578 1.4079 0.0365 1.0443 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 433: 92.1783 -5.8618 -2.1512 -4.2711 -0.9351 0.2276 0.0378 3.4867 1.0768 2.8554 0.1447 0.1577 1.4078 0.0366 1.0440 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 434: 92.1784 -5.8612 -2.1513 -4.2714 -0.9350 0.2278 0.0378 3.4858 1.0774 2.8564 0.1448 0.1577 1.4074 0.0365 1.0430 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 435: 92.1783 -5.8610 -2.1513 -4.2718 -0.9348 0.2279 0.0377 3.4874 1.0779 2.8581 0.1448 0.1576 1.4072 0.0366 1.0423 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 436: 92.1781 -5.8610 -2.1513 -4.2721 -0.9346 0.2280 0.0376 3.4879 1.0789 2.8598 0.1448 0.1575 1.4070 0.0365 1.0417 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 437: 92.1781 -5.8610 -2.1511 -4.2726 -0.9345 0.2279 0.0376 3.4886 1.0794 2.8618 0.1449 0.1574 1.4071 0.0365 1.0417 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 438: 92.1781 -5.8609 -2.1510 -4.2730 -0.9345 0.2280 0.0375 3.4893 1.0797 2.8641 0.1449 0.1573 1.4075 0.0365 1.0420 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 439: 92.1781 -5.8608 -2.1509 -4.2734 -0.9343 0.2280 0.0374 3.4894 1.0803 2.8659 0.1449 0.1573 1.4076 0.0365 1.0421 0.0739</span> +<span class="r-out co"><span class="r-pr">#></span> 440: 92.1780 -5.8603 -2.1510 -4.2737 -0.9343 0.2279 0.0374 3.4885 1.0808 2.8674 0.1448 0.1573 1.4079 0.0365 1.0430 0.0738</span> +<span class="r-out co"><span class="r-pr">#></span> 441: 92.1779 -5.8600 -2.1510 -4.2738 -0.9342 0.2279 0.0373 3.4899 1.0811 2.8686 0.1447 0.1574 1.4086 0.0365 1.0445 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 442: 92.1779 -5.8600 -2.1509 -4.2737 -0.9343 0.2278 0.0372 3.4925 1.0814 2.8691 0.1447 0.1575 1.4088 0.0365 1.0451 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 443: 92.1780 -5.8598 -2.1509 -4.2739 -0.9341 0.2278 0.0372 3.4949 1.0819 2.8705 0.1447 0.1576 1.4092 0.0365 1.0453 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 444: 92.1779 -5.8593 -2.1510 -4.2742 -0.9340 0.2277 0.0371 3.4951 1.0824 2.8717 0.1447 0.1576 1.4096 0.0365 1.0455 0.0737</span> +<span class="r-out co"><span class="r-pr">#></span> 445: 92.1777 -5.8593 -2.1511 -4.2744 -0.9338 0.2275 0.0371 3.4999 1.0828 2.8729 0.1448 0.1576 1.4100 0.0365 1.0461 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 446: 92.1774 -5.8600 -2.1511 -4.2748 -0.9338 0.2274 0.0372 3.5051 1.0837 2.8747 0.1449 0.1576 1.4099 0.0365 1.0464 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 447: 92.1771 -5.8604 -2.1512 -4.2751 -0.9338 0.2273 0.0373 3.5087 1.0844 2.8758 0.1449 0.1575 1.4097 0.0365 1.0467 0.0736</span> +<span class="r-out co"><span class="r-pr">#></span> 448: 92.1769 -5.8607 -2.1513 -4.2756 -0.9336 0.2272 0.0374 3.5124 1.0849 2.8778 0.1449 0.1575 1.4098 0.0365 1.0470 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 449: 92.1768 -5.8611 -2.1515 -4.2759 -0.9337 0.2270 0.0374 3.5165 1.0853 2.8789 0.1449 0.1575 1.4101 0.0365 1.0473 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 450: 92.1766 -5.8611 -2.1515 -4.2762 -0.9337 0.2269 0.0374 3.5158 1.0859 2.8800 0.1448 0.1576 1.4102 0.0365 1.0474 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 451: 92.1762 -5.8615 -2.1514 -4.2765 -0.9337 0.2267 0.0374 3.5202 1.0866 2.8812 0.1447 0.1576 1.4104 0.0365 1.0477 0.0735</span> +<span class="r-out co"><span class="r-pr">#></span> 452: 92.1761 -5.8622 -2.1514 -4.2767 -0.9337 0.2264 0.0374 3.5232 1.0871 2.8824 0.1447 0.1576 1.4103 0.0365 1.0479 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 453: 92.1760 -5.8621 -2.1514 -4.2776 -0.9336 0.2261 0.0373 3.5247 1.0878 2.8901 0.1447 0.1576 1.4103 0.0365 1.0480 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 454: 92.1759 -5.8611 -2.1513 -4.2781 -0.9335 0.2259 0.0373 3.5206 1.0882 2.8939 0.1448 0.1575 1.4104 0.0365 1.0483 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 455: 92.1758 -5.8599 -2.1513 -4.2788 -0.9336 0.2258 0.0372 3.5151 1.0887 2.9010 0.1448 0.1575 1.4104 0.0365 1.0485 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 456: 92.1760 -5.8583 -2.1512 -4.2797 -0.9335 0.2258 0.0372 3.5086 1.0892 2.9081 0.1448 0.1574 1.4105 0.0365 1.0483 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 457: 92.1761 -5.8575 -2.1513 -4.2804 -0.9334 0.2257 0.0371 3.5041 1.0896 2.9144 0.1449 0.1574 1.4103 0.0365 1.0480 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 458: 92.1763 -5.8569 -2.1512 -4.2813 -0.9334 0.2257 0.0370 3.5014 1.0901 2.9227 0.1449 0.1574 1.4102 0.0365 1.0476 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 459: 92.1763 -5.8565 -2.1512 -4.2816 -0.9334 0.2256 0.0370 3.4991 1.0908 2.9248 0.1449 0.1573 1.4100 0.0365 1.0471 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 460: 92.1764 -5.8557 -2.1513 -4.2818 -0.9333 0.2256 0.0370 3.4957 1.0915 2.9258 0.1449 0.1572 1.4097 0.0365 1.0466 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 461: 92.1765 -5.8550 -2.1515 -4.2822 -0.9333 0.2255 0.0370 3.4923 1.0921 2.9296 0.1449 0.1571 1.4097 0.0365 1.0464 0.0734</span> +<span class="r-out co"><span class="r-pr">#></span> 462: 92.1764 -5.8546 -2.1517 -4.2824 -0.9333 0.2256 0.0370 3.4897 1.0925 2.9319 0.1448 0.1569 1.4093 0.0365 1.0463 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 463: 92.1763 -5.8539 -2.1519 -4.2830 -0.9333 0.2256 0.0369 3.4863 1.0928 2.9373 0.1449 0.1568 1.4093 0.0366 1.0463 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 464: 92.1763 -5.8532 -2.1520 -4.2833 -0.9333 0.2257 0.0370 3.4825 1.0933 2.9405 0.1448 0.1567 1.4093 0.0366 1.0462 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 465: 92.1762 -5.8528 -2.1521 -4.2837 -0.9335 0.2257 0.0370 3.4795 1.0938 2.9433 0.1448 0.1567 1.4093 0.0366 1.0464 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 466: 92.1762 -5.8530 -2.1523 -4.2840 -0.9336 0.2256 0.0370 3.4780 1.0943 2.9462 0.1448 0.1566 1.4089 0.0366 1.0466 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 467: 92.1764 -5.8529 -2.1524 -4.2846 -0.9337 0.2256 0.0371 3.4751 1.0948 2.9506 0.1447 0.1565 1.4087 0.0366 1.0465 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 468: 92.1765 -5.8531 -2.1525 -4.2849 -0.9337 0.2255 0.0371 3.4734 1.0952 2.9523 0.1447 0.1563 1.4087 0.0366 1.0465 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 469: 92.1767 -5.8533 -2.1525 -4.2853 -0.9337 0.2254 0.0372 3.4754 1.0958 2.9540 0.1447 0.1561 1.4090 0.0366 1.0472 0.0733</span> +<span class="r-out co"><span class="r-pr">#></span> 470: 92.1767 -5.8536 -2.1525 -4.2858 -0.9338 0.2254 0.0373 3.4780 1.0965 2.9571 0.1448 0.1559 1.4094 0.0366 1.0478 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 471: 92.1767 -5.8540 -2.1525 -4.2864 -0.9338 0.2254 0.0373 3.4812 1.0970 2.9606 0.1447 0.1558 1.4099 0.0366 1.0482 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 472: 92.1766 -5.8547 -2.1526 -4.2871 -0.9339 0.2255 0.0373 3.4844 1.0975 2.9645 0.1446 0.1556 1.4101 0.0366 1.0482 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 473: 92.1764 -5.8549 -2.1527 -4.2875 -0.9339 0.2255 0.0373 3.4848 1.0977 2.9672 0.1446 0.1554 1.4100 0.0366 1.0482 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 474: 92.1762 -5.8553 -2.1528 -4.2880 -0.9338 0.2256 0.0373 3.4855 1.0979 2.9700 0.1445 0.1552 1.4104 0.0366 1.0484 0.0732</span> +<span class="r-out co"><span class="r-pr">#></span> 475: 92.1763 -5.8561 -2.1530 -4.2884 -0.9338 0.2256 0.0374 3.4885 1.0981 2.9726 0.1445 0.1549 1.4103 0.0366 1.0484 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 476: 92.1763 -5.8564 -2.1530 -4.2885 -0.9339 0.2258 0.0374 3.4914 1.0983 2.9734 0.1444 0.1548 1.4106 0.0366 1.0484 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 477: 92.1763 -5.8565 -2.1531 -4.2888 -0.9340 0.2259 0.0373 3.4941 1.0985 2.9755 0.1443 0.1546 1.4108 0.0366 1.0487 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 478: 92.1763 -5.8576 -2.1532 -4.2889 -0.9340 0.2258 0.0373 3.4995 1.0987 2.9772 0.1442 0.1544 1.4111 0.0366 1.0490 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 479: 92.1765 -5.8593 -2.1533 -4.2890 -0.9342 0.2259 0.0372 3.5086 1.0990 2.9787 0.1442 0.1544 1.4113 0.0366 1.0495 0.0731</span> +<span class="r-out co"><span class="r-pr">#></span> 480: 92.1766 -5.8613 -2.1535 -4.2892 -0.9342 0.2260 0.0372 3.5233 1.0991 2.9800 0.1442 0.1543 1.4116 0.0367 1.0496 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 481: 92.1768 -5.8624 -2.1536 -4.2894 -0.9341 0.2260 0.0371 3.5309 1.0993 2.9820 0.1442 0.1542 1.4117 0.0367 1.0497 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 482: 92.1766 -5.8634 -2.1537 -4.2896 -0.9341 0.2260 0.0371 3.5393 1.0995 2.9833 0.1443 0.1542 1.4116 0.0367 1.0496 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 483: 92.1762 -5.8645 -2.1538 -4.2896 -0.9340 0.2260 0.0372 3.5472 1.0997 2.9840 0.1443 0.1542 1.4115 0.0367 1.0498 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 484: 92.1757 -5.8648 -2.1538 -4.2896 -0.9340 0.2261 0.0373 3.5508 1.0998 2.9843 0.1445 0.1542 1.4115 0.0366 1.0498 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 485: 92.1752 -5.8648 -2.1539 -4.2896 -0.9340 0.2262 0.0374 3.5516 1.1000 2.9846 0.1445 0.1542 1.4115 0.0366 1.0497 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 486: 92.1747 -5.8649 -2.1539 -4.2897 -0.9340 0.2262 0.0375 3.5517 1.1003 2.9856 0.1446 0.1541 1.4113 0.0366 1.0498 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 487: 92.1743 -5.8649 -2.1539 -4.2896 -0.9340 0.2262 0.0376 3.5502 1.1006 2.9856 0.1447 0.1539 1.4110 0.0367 1.0498 0.0730</span> +<span class="r-out co"><span class="r-pr">#></span> 488: 92.1739 -5.8645 -2.1540 -4.2893 -0.9340 0.2261 0.0377 3.5475 1.1008 2.9848 0.1447 0.1537 1.4106 0.0367 1.0497 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 489: 92.1736 -5.8640 -2.1539 -4.2892 -0.9340 0.2260 0.0376 3.5445 1.1011 2.9844 0.1448 0.1536 1.4105 0.0367 1.0496 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 490: 92.1736 -5.8631 -2.1539 -4.2889 -0.9340 0.2260 0.0376 3.5402 1.1014 2.9835 0.1448 0.1534 1.4103 0.0366 1.0496 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 491: 92.1735 -5.8617 -2.1539 -4.2887 -0.9339 0.2260 0.0375 3.5343 1.1016 2.9825 0.1449 0.1532 1.4103 0.0366 1.0497 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 492: 92.1736 -5.8609 -2.1539 -4.2884 -0.9339 0.2259 0.0375 3.5298 1.1017 2.9816 0.1449 0.1530 1.4101 0.0367 1.0499 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 493: 92.1737 -5.8605 -2.1539 -4.2882 -0.9339 0.2260 0.0375 3.5266 1.1018 2.9807 0.1450 0.1529 1.4098 0.0367 1.0496 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 494: 92.1739 -5.8609 -2.1539 -4.2881 -0.9340 0.2261 0.0375 3.5273 1.1018 2.9802 0.1450 0.1528 1.4097 0.0367 1.0495 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 495: 92.1741 -5.8614 -2.1540 -4.2880 -0.9340 0.2262 0.0376 3.5290 1.1019 2.9797 0.1450 0.1526 1.4096 0.0367 1.0492 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 496: 92.1742 -5.8623 -2.1540 -4.2879 -0.9341 0.2262 0.0376 3.5348 1.1020 2.9791 0.1449 0.1525 1.4096 0.0367 1.0491 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 497: 92.1742 -5.8634 -2.1541 -4.2879 -0.9341 0.2264 0.0377 3.5402 1.1020 2.9789 0.1449 0.1524 1.4097 0.0367 1.0493 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 498: 92.1744 -5.8637 -2.1543 -4.2879 -0.9341 0.2266 0.0377 3.5406 1.1019 2.9787 0.1449 0.1524 1.4096 0.0367 1.0496 0.0729</span> +<span class="r-out co"><span class="r-pr">#></span> 499: 92.1744 -5.8635 -2.1544 -4.2880 -0.9341 0.2268 0.0376 3.5400 1.1019 2.9789 0.1450 0.1523 1.4095 0.0367 1.0500 0.0728</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 92.1744 -5.8628 -2.1545 -4.2882 -0.9341 0.2270 0.0377 3.5381 1.1020 2.9795 0.1450 0.1522 1.4096 0.0367 1.0503 0.0728</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> +<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis |sigma_low_parent |rsd_high_parent |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................|sigma_low_A1 |rsd_high_A1 | o1 | o2 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o3 | o4 | o5 | o6 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 495.48573 | 1.000 | -1.000 | -0.9104 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9875 | -0.8823 | -0.8746 | -0.8907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8746 | -0.8907 | -0.8767 | -0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8673 | -0.8720 | -0.8739 | -0.8666 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.48573 | 91.00 | -5.200 | -0.8900 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4600 | 0.8300 | 0.05800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.05800 | 0.7311 | 0.9036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.183 | 0.9554 | 0.8633 | 1.214 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.48573</span> | 91.00 | 0.005517 | 0.2911 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01005 | 0.6130 | 0.8300 | 0.05800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.05800 | 0.7311 | 0.9036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.183 | 0.9554 | 0.8633 | 1.214 |</span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -0.9648 | 2.223 | -0.3153 | -0.01817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3350 | 0.6789 | -23.42 | -17.64 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.440 | -1.950 | 0.9642 | 9.851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -11.94 | -1.319 | 8.578 | -12.45 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 481.75012 | 1.026 | -1.060 | -0.9019 | -0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9785 | -0.9007 | -0.2420 | -0.4142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7277 | -0.8380 | -0.9027 | -1.139 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8364 | -1.106 | -0.5303 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.75012 | 93.37 | -5.260 | -0.8824 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4516 | 1.093 | 0.07182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8910 | 0.05953 | 0.7121 | 0.6631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9895 | 0.6633 | 1.623 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.75012</span> | 93.37 | 0.005195 | 0.2927 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.093 | 0.07182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8910 | 0.05953 | 0.7121 | 0.6631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9895 | 0.6633 | 1.623 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 152.5 | 1.317 | 3.315 | -0.1772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3391 | 0.1426 | -4.513 | 6.696 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.211 | 0.7988 | 0.6299 | -5.324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009964 | 3.044 | -5.727 | -6.694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 3004.9713 | 0.2745 | -1.093 | -0.9147 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9762 | -0.9095 | 0.05941 | -0.2377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6690 | -0.8188 | -0.9174 | -1.204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4027 | -0.8359 | -1.205 | -0.3486 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 3004.9713 | 24.98 | -5.293 | -0.8938 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.589 | 0.4475 | 1.218 | 0.07694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9154 | 0.06008 | 0.7014 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.733 | 0.9899 | 0.5774 | 1.843 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 3004.9713</span> | 24.98 | 0.005026 | 0.2903 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01017 | 0.6100 | 1.218 | 0.07694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9154 | 0.06008 | 0.7014 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.733 | 0.9899 | 0.5774 | 1.843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 491.68825 | 0.9393 | -1.061 | -0.9038 | -0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9787 | -0.9008 | -0.2394 | -0.4180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7284 | -0.8385 | -0.9031 | -1.136 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8381 | -1.102 | -0.5265 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.68825 | 85.47 | -5.261 | -0.8841 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4515 | 1.094 | 0.07171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05951 | 0.7118 | 0.6659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9878 | 0.6661 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.68825</span> | 85.47 | 0.005191 | 0.2923 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.094 | 0.07171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05951 | 0.7118 | 0.6659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9878 | 0.6661 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 479.72282 | 1.001 | -1.060 | -0.9024 | -0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9785 | -0.9007 | -0.2413 | -0.4153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7279 | -0.8381 | -0.9028 | -1.138 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8369 | -1.105 | -0.5292 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.72282 | 91.11 | -5.260 | -0.8829 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4516 | 1.093 | 0.07179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8909 | 0.05952 | 0.7120 | 0.6639 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9890 | 0.6641 | 1.624 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.72282</span> | 91.11 | 0.005194 | 0.2926 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.093 | 0.07179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8909 | 0.05952 | 0.7120 | 0.6639 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9890 | 0.6641 | 1.624 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.589 | 1.222 | 0.9137 | 0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3993 | 0.5206 | -3.904 | 6.654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9090 | 1.134 | -1.839 | -6.108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 4.007 | -4.921 | -6.374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 479.56384 | 0.9950 | -1.061 | -0.9037 | -0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9792 | -0.9012 | -0.2438 | -0.4298 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7309 | -0.8403 | -0.9001 | -1.126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5509 | -0.8426 | -1.095 | -0.5241 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.56384 | 90.55 | -5.261 | -0.8840 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4513 | 1.092 | 0.07137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8897 | 0.05946 | 0.7140 | 0.6748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9836 | 0.6729 | 1.630 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56384</span> | 90.55 | 0.005189 | 0.2923 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.092 | 0.07137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8897 | 0.05946 | 0.7140 | 0.6748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9836 | 0.6729 | 1.630 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.71 | 1.225 | 0.1963 | 0.1681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4113 | 0.6853 | -4.208 | 6.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7033 | 1.163 | -2.029 | -4.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.106 | 3.494 | -3.921 | -6.098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 479.23599 | 1.003 | -1.063 | -0.9048 | -0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9799 | -0.9023 | -0.2352 | -0.4403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7320 | -0.8422 | -0.8974 | -1.117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5472 | -0.8484 | -1.086 | -0.5115 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.23599 | 91.29 | -5.263 | -0.8850 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4508 | 1.095 | 0.07106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8892 | 0.05941 | 0.7160 | 0.6828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9781 | 0.6800 | 1.645 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.23599</span> | 91.29 | 0.005177 | 0.2921 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6108 | 1.095 | 0.07106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8892 | 0.05941 | 0.7160 | 0.6828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9781 | 0.6800 | 1.645 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.36 | 1.286 | 0.8956 | 0.06941 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3942 | 0.6495 | -3.460 | 6.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7828 | 0.9998 | -1.947 | -2.931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1591 | 2.144 | -3.375 | -5.909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 479.05200 | 0.9982 | -1.066 | -0.9056 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9803 | -0.9037 | -0.2181 | -0.4407 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7304 | -0.8427 | -0.8951 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5384 | -0.8504 | -1.087 | -0.4972 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.052 | 90.84 | -5.266 | -0.8857 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4502 | 1.102 | 0.07105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8899 | 0.05939 | 0.7177 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9761 | 0.6797 | 1.663 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.052</span> | 90.84 | 0.005162 | 0.2920 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6107 | 1.102 | 0.07105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8899 | 0.05939 | 0.7177 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9761 | 0.6797 | 1.663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 478.91507 | 0.9977 | -1.070 | -0.9061 | -0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9807 | -0.9051 | -0.2002 | -0.4395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7284 | -0.8431 | -0.8930 | -1.121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5287 | -0.8520 | -1.088 | -0.4828 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.91507 | 90.79 | -5.270 | -0.8862 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4495 | 1.110 | 0.07109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05938 | 0.7192 | 0.6799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9745 | 0.6785 | 1.680 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.91507</span> | 90.79 | 0.005146 | 0.2919 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6105 | 1.110 | 0.07109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05938 | 0.7192 | 0.6799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9745 | 0.6785 | 1.680 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 478.54700 | 0.9959 | -1.080 | -0.9081 | -0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9820 | -0.9099 | -0.1391 | -0.4353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7215 | -0.8442 | -0.8862 | -1.128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4957 | -0.8577 | -1.093 | -0.4342 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.547 | 90.63 | -5.280 | -0.8880 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4473 | 1.135 | 0.07121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8936 | 0.05935 | 0.7242 | 0.6734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9691 | 0.6746 | 1.739 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.547</span> | 90.63 | 0.005094 | 0.2915 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6100 | 1.135 | 0.07121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8936 | 0.05935 | 0.7242 | 0.6734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9691 | 0.6746 | 1.739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 478.24707 | 0.9926 | -1.098 | -0.9118 | -0.9388 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9843 | -0.9186 | -0.02735 | -0.4276 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7088 | -0.8464 | -0.8736 | -1.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4354 | -0.8680 | -1.101 | -0.3451 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.24707 | 90.33 | -5.298 | -0.8913 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.597 | 0.4433 | 1.182 | 0.07143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8988 | 0.05929 | 0.7334 | 0.6616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.694 | 0.9593 | 0.6674 | 1.848 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.24707</span> | 90.33 | 0.004999 | 0.2909 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01008 | 0.6090 | 1.182 | 0.07143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8988 | 0.05929 | 0.7334 | 0.6616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.694 | 0.9593 | 0.6674 | 1.848 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -54.86 | 1.159 | -0.2545 | 0.1198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4779 | 1.320 | -1.627 | 7.719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.194 | -2.008 | -4.434 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.563 | 0.8010 | -2.393 | -3.495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 475.90466 | 1.002 | -1.127 | -0.9233 | -0.9398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9978 | -0.9482 | -0.05448 | -0.6822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7579 | -0.8801 | -0.8190 | -1.095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4550 | -0.8498 | -1.031 | -0.2699 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.90466 | 91.18 | -5.327 | -0.9014 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.610 | 0.4297 | 1.170 | 0.06405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05831 | 0.7733 | 0.7032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.671 | 0.9767 | 0.7277 | 1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.90466</span> | 91.18 | 0.004860 | 0.2888 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009950 | 0.6058 | 1.170 | 0.06405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05831 | 0.7733 | 0.7032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.671 | 0.9767 | 0.7277 | 1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.773 | 1.281 | 0.05418 | -0.06269 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4104 | 1.812 | -4.981 | 3.640 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08126 | 0.09477 | -1.092 | -2.966 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.262 | 2.712 | 3.245 | -2.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 477.06760 | 1.030 | -1.176 | -0.9281 | -0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.011 | 0.09564 | -0.8420 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7668 | -0.8907 | -0.7738 | -1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5619 | -0.8693 | -1.126 | -0.1773 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.0676 | 93.71 | -5.376 | -0.9057 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4008 | 1.233 | 0.05941 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8748 | 0.05800 | 0.8064 | 0.7234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.545 | 0.9581 | 0.6461 | 2.051 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.0676</span> | 93.71 | 0.004627 | 0.2879 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009799 | 0.5989 | 1.233 | 0.05941 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8748 | 0.05800 | 0.8064 | 0.7234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.545 | 0.9581 | 0.6461 | 2.051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 477.20174 | 1.026 | -1.143 | -0.9246 | -0.9391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9695 | -0.001726 | -0.7335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8831 | -0.8043 | -1.080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4976 | -0.8627 | -1.065 | -0.2404 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.20174 | 93.37 | -5.343 | -0.9027 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4199 | 1.192 | 0.06256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05822 | 0.7840 | 0.7162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.621 | 0.9644 | 0.6988 | 1.975 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.20174</span> | 93.37 | 0.004782 | 0.2885 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009899 | 0.6035 | 1.192 | 0.06256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05822 | 0.7840 | 0.7162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.621 | 0.9644 | 0.6988 | 1.975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 476.22973 | 1.014 | -1.129 | -0.9234 | -0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9986 | -0.9521 | -0.04396 | -0.6899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7577 | -0.8803 | -0.8167 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4661 | -0.8555 | -1.038 | -0.2656 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.22973 | 92.29 | -5.329 | -0.9015 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4279 | 1.175 | 0.06382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7750 | 0.7089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9712 | 0.7218 | 1.944 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.22973</span> | 92.29 | 0.004847 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009941 | 0.6054 | 1.175 | 0.06382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7750 | 0.7089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9712 | 0.7218 | 1.944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 475.87776 | 1.005 | -1.127 | -0.9233 | -0.9398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9980 | -0.9491 | -0.05201 | -0.6840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7578 | -0.8802 | -0.8184 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4576 | -0.8511 | -1.033 | -0.2689 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.87776 | 91.44 | -5.327 | -0.9015 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.610 | 0.4293 | 1.171 | 0.06399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7737 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.668 | 0.9754 | 0.7263 | 1.940 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.87776</span> | 91.44 | 0.004857 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009948 | 0.6057 | 1.171 | 0.06399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7737 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.668 | 0.9754 | 0.7263 | 1.940 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.12 | 1.298 | 0.4116 | -0.09723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4002 | 1.728 | -4.991 | 3.781 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06392 | 0.04117 | -1.251 | -0.6787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.079 | 2.620 | 3.013 | -2.074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 475.82399 | 1.002 | -1.128 | -0.9234 | -0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9982 | -0.9501 | -0.04950 | -0.6866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7580 | -0.8803 | -0.8177 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4596 | -0.8518 | -1.034 | -0.2675 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.82399 | 91.17 | -5.328 | -0.9016 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4288 | 1.172 | 0.06392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7743 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.666 | 0.9748 | 0.7251 | 1.942 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.82399</span> | 91.17 | 0.004853 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009945 | 0.6056 | 1.172 | 0.06392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7743 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.666 | 0.9748 | 0.7251 | 1.942 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.267 | 1.279 | 0.007095 | -0.05940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4115 | 1.783 | -5.114 | 3.652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1068 | 0.1083 | -1.295 | -0.9578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.682 | 2.514 | 3.014 | -2.035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 475.78862 | 1.005 | -1.129 | -0.9235 | -0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9985 | -0.9512 | -0.04657 | -0.6892 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7580 | -0.8804 | -0.8168 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4611 | -0.8527 | -1.036 | -0.2661 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.78862 | 91.41 | -5.329 | -0.9016 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4283 | 1.174 | 0.06384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7749 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.664 | 0.9739 | 0.7236 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.78862</span> | 91.41 | 0.004849 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009942 | 0.6055 | 1.174 | 0.06384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7749 | 0.7045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.664 | 0.9739 | 0.7236 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.19 | 1.292 | 0.3498 | -0.09321 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4023 | 1.703 | -5.372 | 3.699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1234 | 0.05429 | -1.241 | -0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.815 | 2.436 | 2.783 | -2.083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 475.73531 | 1.002 | -1.130 | -0.9236 | -0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9987 | -0.9524 | -0.04361 | -0.6921 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7582 | -0.8806 | -0.8159 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4630 | -0.8531 | -1.037 | -0.2646 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.73531 | 91.21 | -5.330 | -0.9018 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4278 | 1.175 | 0.06376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7756 | 0.7041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.662 | 0.9735 | 0.7222 | 1.945 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.73531</span> | 91.21 | 0.004845 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009940 | 0.6053 | 1.175 | 0.06376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7756 | 0.7041 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.662 | 0.9735 | 0.7222 | 1.945 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.312 | 1.277 | 0.06663 | -0.06695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4102 | 1.736 | -5.095 | 3.555 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08175 | 0.08515 | -1.253 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.836 | 2.452 | 2.739 | -2.058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 475.69941 | 1.004 | -1.131 | -0.9237 | -0.9396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9990 | -0.9534 | -0.04063 | -0.6942 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7581 | -0.8807 | -0.8151 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4658 | -0.8545 | -1.039 | -0.2634 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.69941 | 91.39 | -5.331 | -0.9018 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4273 | 1.176 | 0.06370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7761 | 0.7046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9722 | 0.7208 | 1.947 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.69941</span> | 91.39 | 0.004841 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009937 | 0.6052 | 1.176 | 0.06370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7761 | 0.7046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9722 | 0.7208 | 1.947 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.57 | 1.287 | 0.3079 | -0.08979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4039 | 1.674 | -5.153 | 3.653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06063 | 0.04440 | -1.200 | -0.7646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.452 | 2.339 | 2.552 | -2.095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 475.66307 | 1.001 | -1.131 | -0.9238 | -0.9396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9992 | -0.9545 | -0.03780 | -0.6969 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7583 | -0.8808 | -0.8143 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4671 | -0.8550 | -1.041 | -0.2620 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.66307 | 91.11 | -5.331 | -0.9019 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4268 | 1.177 | 0.06362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7767 | 0.7044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.657 | 0.9717 | 0.7195 | 1.948 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.66307</span> | 91.11 | 0.004837 | 0.2887 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009935 | 0.6051 | 1.177 | 0.06362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7767 | 0.7044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.657 | 0.9717 | 0.7195 | 1.948 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.57 | 1.267 | -0.09715 | -0.05310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4138 | 1.728 | -5.558 | 3.438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1081 | 0.1203 | -1.232 | -1.053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.344 | 2.291 | 2.543 | -2.059 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 475.61346 | 1.003 | -1.132 | -0.9238 | -0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9995 | -0.9557 | -0.03467 | -0.6999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7585 | -0.8810 | -0.8134 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4680 | -0.8550 | -1.042 | -0.2607 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.61346 | 91.32 | -5.332 | -0.9020 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4262 | 1.179 | 0.06353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7774 | 0.7040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.656 | 0.9717 | 0.7181 | 1.950 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.61346</span> | 91.32 | 0.004833 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009932 | 0.6050 | 1.179 | 0.06353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7774 | 0.7040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.656 | 0.9717 | 0.7181 | 1.950 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.192 | 1.277 | 0.1967 | -0.08157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4060 | 1.656 | -5.231 | 3.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1038 | 0.05786 | -1.199 | -0.8859 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.283 | 2.293 | 2.331 | -2.101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 475.58436 | 1.001 | -1.133 | -0.9239 | -0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9998 | -0.9568 | -0.03140 | -0.7025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7585 | -0.8810 | -0.8126 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4692 | -0.8560 | -1.044 | -0.2594 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.58436 | 91.09 | -5.333 | -0.9021 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4257 | 1.180 | 0.06346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7780 | 0.7043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.654 | 0.9707 | 0.7167 | 1.952 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.58436</span> | 91.09 | 0.004829 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009929 | 0.6049 | 1.180 | 0.06346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7780 | 0.7043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.654 | 0.9707 | 0.7167 | 1.952 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.46 | 1.261 | -0.1306 | -0.05131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4140 | 1.696 | -5.518 | 3.404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1407 | 0.1181 | -1.199 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.272 | 2.212 | 2.296 | -2.075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 475.53229 | 1.003 | -1.134 | -0.9240 | -0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9581 | -0.02828 | -0.7055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7587 | -0.8812 | -0.8117 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4701 | -0.8560 | -1.045 | -0.2580 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.53229 | 91.31 | -5.334 | -0.9021 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4251 | 1.181 | 0.06337 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7786 | 0.7039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.653 | 0.9708 | 0.7153 | 1.953 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.53229</span> | 91.31 | 0.004824 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009926 | 0.6047 | 1.181 | 0.06337 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7786 | 0.7039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.653 | 0.9708 | 0.7153 | 1.953 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.355 | 1.271 | 0.1786 | -0.08149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4055 | 1.621 | -5.117 | 3.557 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1060 | 0.04285 | -0.9518 | -2.902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.469 | 2.204 | 2.093 | -2.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 475.50379 | 1.001 | -1.135 | -0.9241 | -0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9591 | -0.02533 | -0.7076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7587 | -0.8812 | -0.8111 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4726 | -0.8571 | -1.047 | -0.2568 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.50379 | 91.10 | -5.335 | -0.9022 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4247 | 1.182 | 0.06331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7790 | 0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | 0.9697 | 0.7143 | 1.955 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.50379</span> | 91.10 | 0.004820 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009924 | 0.6046 | 1.182 | 0.06331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7790 | 0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | 0.9697 | 0.7143 | 1.955 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.73 | 1.259 | -0.1294 | -0.05234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4131 | 1.659 | -5.626 | 3.356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1179 | 0.1182 | -1.163 | -0.9759 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.282 | 2.162 | 2.085 | -2.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 475.45890 | 1.004 | -1.136 | -0.9240 | -0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9602 | -0.02221 | -0.7103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7588 | -0.8813 | -0.8104 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4738 | -0.8571 | -1.048 | -0.2555 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.4589 | 91.37 | -5.336 | -0.9021 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4242 | 1.184 | 0.06323 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05827 | 0.7796 | 0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.649 | 0.9697 | 0.7132 | 1.956 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.4589</span> | 91.37 | 0.004816 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009921 | 0.6045 | 1.184 | 0.06323 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05827 | 0.7796 | 0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.649 | 0.9697 | 0.7132 | 1.956 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.388 | 1.275 | 0.2447 | -0.08891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4027 | 1.576 | -4.598 | 3.539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08390 | 0.04261 | -0.9004 | -2.725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.305 | 2.111 | 1.882 | -2.135 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 475.41657 | 1.002 | -1.137 | -0.9241 | -0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9615 | -0.01910 | -0.7133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7590 | -0.8814 | -0.8097 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4754 | -0.8571 | -1.049 | -0.2540 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.41657 | 91.17 | -5.337 | -0.9022 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4236 | 1.185 | 0.06314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7801 | 0.7060 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.647 | 0.9697 | 0.7121 | 1.958 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.41657</span> | 91.17 | 0.004811 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009918 | 0.6043 | 1.185 | 0.06314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7801 | 0.7060 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.647 | 0.9697 | 0.7121 | 1.958 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.291 | 1.263 | -0.02799 | -0.06240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4098 | 1.607 | -5.561 | 3.409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1363 | 0.09124 | -1.126 | -0.9025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.264 | 2.123 | 1.858 | -2.103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 475.37603 | 1.004 | -1.138 | -0.9241 | -0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9626 | -0.01569 | -0.7160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7590 | -0.8815 | -0.8090 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4775 | -0.8574 | -1.050 | -0.2525 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.37603 | 91.35 | -5.338 | -0.9022 | -2.202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4231 | 1.186 | 0.06307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7806 | 0.7060 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.645 | 0.9695 | 0.7112 | 1.960 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.37603</span> | 91.35 | 0.004807 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009915 | 0.6042 | 1.186 | 0.06307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7806 | 0.7060 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.645 | 0.9695 | 0.7112 | 1.960 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.976 | 1.271 | 0.2167 | -0.08766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4024 | 1.550 | -5.132 | 3.516 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09627 | 0.04106 | -1.088 | -0.7404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.103 | 2.126 | 1.707 | -2.133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 475.34297 | 1.001 | -1.139 | -0.9242 | -0.9391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9636 | -0.01242 | -0.7185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7591 | -0.8816 | -0.8082 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4796 | -0.8578 | -1.051 | -0.2511 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.34297 | 91.13 | -5.339 | -0.9023 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4226 | 1.188 | 0.06299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7812 | 0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.642 | 0.9691 | 0.7103 | 1.962 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.34297</span> | 91.13 | 0.004803 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009912 | 0.6041 | 1.188 | 0.06299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7812 | 0.7056 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.642 | 0.9691 | 0.7103 | 1.962 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.69 | 1.251 | -0.09758 | -0.05188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4100 | 1.596 | -5.544 | 3.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1288 | 0.09302 | -1.103 | -0.9943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.044 | 2.113 | 1.726 | -2.096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 475.29763 | 1.004 | -1.140 | -0.9242 | -0.9391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9647 | -0.009016 | -0.7212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7592 | -0.8817 | -0.8074 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4815 | -0.8578 | -1.052 | -0.2496 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.29763 | 91.33 | -5.340 | -0.9023 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4221 | 1.189 | 0.06292 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7818 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.640 | 0.9691 | 0.7096 | 1.964 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.29763</span> | 91.33 | 0.004798 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009909 | 0.6040 | 1.189 | 0.06292 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7818 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.640 | 0.9691 | 0.7096 | 1.964 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.626 | 1.261 | 0.1834 | -0.08674 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4019 | 1.535 | -5.612 | 3.466 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1091 | 0.03444 | -1.082 | -0.8814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.882 | 2.084 | 1.576 | -2.128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 475.26968 | 1.001 | -1.140 | -0.9243 | -0.9390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9656 | -0.005554 | -0.7235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7592 | -0.8818 | -0.8067 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4837 | -0.8585 | -1.053 | -0.2482 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.26968 | 91.11 | -5.340 | -0.9024 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4217 | 1.191 | 0.06285 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7823 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.637 | 0.9684 | 0.7088 | 1.965 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.26968</span> | 91.11 | 0.004794 | 0.2886 | 0.1106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009907 | 0.6039 | 1.191 | 0.06285 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7823 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.637 | 0.9684 | 0.7088 | 1.965 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.71 | 1.246 | -0.1255 | -0.05322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4099 | 1.581 | -5.546 | 3.317 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1509 | 0.1096 | -0.8594 | -3.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.990 | 2.056 | 1.604 | -2.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 475.22190 | 1.004 | -1.141 | -0.9243 | -0.9390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9667 | -0.002058 | -0.7261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7593 | -0.8819 | -0.8061 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4854 | -0.8583 | -1.054 | -0.2469 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.2219 | 91.33 | -5.341 | -0.9024 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4212 | 1.192 | 0.06277 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05826 | 0.7828 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.635 | 0.9686 | 0.7081 | 1.967 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.2219</span> | 91.33 | 0.004790 | 0.2886 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009904 | 0.6038 | 1.192 | 0.06277 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05826 | 0.7828 | 0.7049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.635 | 0.9686 | 0.7081 | 1.967 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.841 | 1.258 | 0.1840 | -0.08823 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4011 | 1.514 | -4.992 | 3.441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1080 | 0.03852 | -1.043 | -0.8514 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.826 | 2.019 | 1.451 | -2.125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 475.19540 | 1.001 | -1.142 | -0.9244 | -0.9389 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9677 | 0.001228 | -0.7286 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7593 | -0.8819 | -0.8054 | -1.093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4876 | -0.8589 | -1.055 | -0.2455 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.1954 | 91.10 | -5.342 | -0.9025 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4207 | 1.193 | 0.06270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7833 | 0.7050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.633 | 0.9680 | 0.7073 | 1.969 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.1954</span> | 91.10 | 0.004786 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009901 | 0.6037 | 1.193 | 0.06270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7833 | 0.7050 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.633 | 0.9680 | 0.7073 | 1.969 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.17 | 1.239 | -0.1323 | -0.05443 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4093 | 1.561 | -5.475 | 3.262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1301 | 0.09817 | -1.038 | -1.045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.818 | 2.054 | 1.474 | -2.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 475.14668 | 1.003 | -1.143 | -0.9244 | -0.9388 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9688 | 0.004635 | -0.7312 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8820 | -0.8046 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4894 | -0.8588 | -1.055 | -0.2440 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.14668 | 91.31 | -5.343 | -0.9025 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4202 | 1.195 | 0.06262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7838 | 0.7043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.631 | 0.9681 | 0.7066 | 1.970 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.14668</span> | 91.31 | 0.004781 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009898 | 0.6035 | 1.195 | 0.06262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7838 | 0.7043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.631 | 0.9681 | 0.7066 | 1.970 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.838 | 1.251 | 0.1547 | -0.08725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4006 | 1.498 | -4.927 | 3.416 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1219 | 0.06473 | -1.010 | -2.917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.712 | 2.020 | 1.337 | -2.117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 475.12366 | 1.001 | -1.144 | -0.9245 | -0.9388 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9698 | 0.007665 | -0.7333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7594 | -0.8821 | -0.8040 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4916 | -0.8600 | -1.056 | -0.2427 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.12366 | 91.10 | -5.344 | -0.9025 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4198 | 1.196 | 0.06256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7843 | 0.7059 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.628 | 0.9669 | 0.7059 | 1.972 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.12366</span> | 91.10 | 0.004777 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009896 | 0.6034 | 1.196 | 0.06256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7843 | 0.7059 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.628 | 0.9669 | 0.7059 | 1.972 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.75 | 1.239 | -0.1466 | -0.05465 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4082 | 1.541 | -5.471 | 3.270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1342 | 0.09829 | -1.014 | -1.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.624 | 1.932 | 1.359 | -2.081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 475.07465 | 1.004 | -1.145 | -0.9245 | -0.9387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9709 | 0.01108 | -0.7360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8821 | -0.8033 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4933 | -0.8597 | -1.057 | -0.2414 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.07465 | 91.33 | -5.345 | -0.9025 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4193 | 1.198 | 0.06248 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7848 | 0.7058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.626 | 0.9672 | 0.7053 | 1.974 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.07465</span> | 91.33 | 0.004773 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009893 | 0.6033 | 1.198 | 0.06248 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7848 | 0.7058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.626 | 0.9672 | 0.7053 | 1.974 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.021 | 1.249 | 0.1599 | -0.08992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3985 | 1.471 | -4.995 | 3.410 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1196 | 0.03779 | -0.9990 | -2.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.497 | 1.906 | 1.211 | -2.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 475.04940 | 1.001 | -1.146 | -0.9245 | -0.9386 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9719 | 0.01438 | -0.7384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7594 | -0.8822 | -0.8026 | -1.091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4953 | -0.8604 | -1.058 | -0.2400 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.0494 | 91.11 | -5.346 | -0.9026 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4188 | 1.199 | 0.06242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7853 | 0.7070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9666 | 0.7046 | 1.975 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.0494</span> | 91.11 | 0.004769 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009890 | 0.6032 | 1.199 | 0.06242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7853 | 0.7070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9666 | 0.7046 | 1.975 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.15 | 1.235 | -0.1370 | -0.05688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4085 | 1.517 | -5.494 | 3.160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1583 | 0.1112 | -0.7821 | -2.927 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.432 | 1.909 | 1.245 | -2.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 475.00092 | 1.004 | -1.147 | -0.9245 | -0.9386 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9731 | 0.01792 | -0.7411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8822 | -0.8020 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4968 | -0.8598 | -1.059 | -0.2387 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.00092 | 91.32 | -5.347 | -0.9025 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4182 | 1.200 | 0.06234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7857 | 0.7077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 0.9671 | 0.7039 | 1.977 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.00092</span> | 91.32 | 0.004764 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009887 | 0.6031 | 1.200 | 0.06234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7857 | 0.7077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 0.9671 | 0.7039 | 1.977 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.379 | 1.249 | 0.1419 | -0.08698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3989 | 1.449 | -4.966 | 3.395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1055 | 0.03295 | -0.9696 | -0.7580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.283 | 1.918 | 1.096 | -2.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 474.98492 | 1.001 | -1.147 | -0.9246 | -0.9385 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9740 | 0.02115 | -0.7433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8822 | -0.8014 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4989 | -0.8610 | -1.059 | -0.2373 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.98492 | 91.07 | -5.347 | -0.9026 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4178 | 1.202 | 0.06227 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7862 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 0.9660 | 0.7033 | 1.978 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.98492</span> | 91.07 | 0.004760 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009884 | 0.6030 | 1.202 | 0.06227 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7862 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 0.9660 | 0.7033 | 1.978 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.65 | 1.231 | -0.1920 | -0.05242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4084 | 1.504 | -5.397 | 3.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1354 | 0.1061 | -0.9468 | -0.9144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.271 | 1.859 | 1.156 | -2.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 474.93249 | 1.004 | -1.148 | -0.9245 | -0.9384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9752 | 0.02452 | -0.7460 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.8007 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5000 | -0.8607 | -1.060 | -0.2361 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.93249 | 91.32 | -5.348 | -0.9026 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4173 | 1.203 | 0.06220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05824 | 0.7867 | 0.7073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.618 | 0.9663 | 0.7027 | 1.980 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.93249</span> | 91.32 | 0.004755 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009881 | 0.6028 | 1.203 | 0.06220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05824 | 0.7867 | 0.7073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.618 | 0.9663 | 0.7027 | 1.980 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.492 | 1.243 | 0.1448 | -0.09052 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3963 | 1.427 | -4.973 | 3.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06414 | 0.02300 | -0.7344 | -2.787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.083 | 1.834 | 0.9813 | -2.110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 474.90355 | 1.001 | -1.149 | -0.9246 | -0.9383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9763 | 0.02806 | -0.7486 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.8002 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5018 | -0.8611 | -1.061 | -0.2347 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.90355 | 91.13 | -5.349 | -0.9026 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4168 | 1.205 | 0.06212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7870 | 0.7084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.616 | 0.9659 | 0.7020 | 1.982 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.90355</span> | 91.13 | 0.004751 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009878 | 0.6027 | 1.205 | 0.06212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7870 | 0.7084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.616 | 0.9659 | 0.7020 | 1.982 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.15 | 1.229 | -0.1075 | -0.06320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4033 | 1.463 | -5.606 | 3.135 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1416 | 0.07801 | -0.9461 | -2.867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.063 | 1.817 | 1.008 | -2.075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 474.85832 | 1.003 | -1.150 | -0.9245 | -0.9383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9775 | 0.03184 | -0.7513 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8823 | -0.7996 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5032 | -0.8605 | -1.061 | -0.2334 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.85832 | 91.32 | -5.350 | -0.9026 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4162 | 1.206 | 0.06204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7875 | 0.7089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.614 | 0.9665 | 0.7015 | 1.983 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.85832</span> | 91.32 | 0.004746 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009875 | 0.6026 | 1.206 | 0.06204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7875 | 0.7089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.614 | 0.9665 | 0.7015 | 1.983 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.689 | 1.242 | 0.1265 | -0.09001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3949 | 1.405 | -5.495 | 3.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1166 | 0.02645 | -0.9105 | -0.7126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.952 | 1.861 | 0.8779 | -2.102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 474.83791 | 1.001 | -1.151 | -0.9246 | -0.9382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9784 | 0.03545 | -0.7535 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.7990 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5052 | -0.8617 | -1.062 | -0.2320 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.83791 | 91.10 | -5.351 | -0.9027 | -2.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4158 | 1.208 | 0.06198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7879 | 0.7094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.612 | 0.9653 | 0.7010 | 1.985 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.83791</span> | 91.10 | 0.004742 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009872 | 0.6025 | 1.208 | 0.06198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7879 | 0.7094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.612 | 0.9653 | 0.7010 | 1.985 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.77 | 1.225 | -0.1616 | -0.05944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4032 | 1.455 | -5.461 | 3.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1419 | 0.08593 | -0.9091 | -0.8855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.951 | 1.791 | 0.9091 | -2.062 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 474.78971 | 1.004 | -1.152 | -0.9246 | -0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9794 | 0.03911 | -0.7559 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7984 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5068 | -0.8614 | -1.062 | -0.2307 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.78971 | 91.33 | -5.352 | -0.9026 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4153 | 1.209 | 0.06191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7883 | 0.7086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.610 | 0.9656 | 0.7006 | 1.986 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.78971</span> | 91.33 | 0.004738 | 0.2885 | 0.1107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009869 | 0.6024 | 1.209 | 0.06191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7883 | 0.7086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.610 | 0.9656 | 0.7006 | 1.986 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.398 | 1.237 | 0.1402 | -0.09195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3940 | 1.388 | -4.885 | 3.322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1374 | 0.01792 | -0.6865 | -2.709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.810 | 1.778 | 0.8100 | -2.095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 474.76763 | 1.001 | -1.153 | -0.9247 | -0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9804 | 0.04256 | -0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7979 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5086 | -0.8621 | -1.063 | -0.2293 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.76763 | 91.11 | -5.353 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4149 | 1.211 | 0.06184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7887 | 0.7097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.608 | 0.9650 | 0.7001 | 1.988 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.76763</span> | 91.11 | 0.004734 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009867 | 0.6023 | 1.211 | 0.06184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7887 | 0.7097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.608 | 0.9650 | 0.7001 | 1.988 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.92 | 1.222 | -0.1466 | -0.06186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4014 | 1.433 | -4.989 | 3.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1326 | 0.08284 | -0.6789 | -2.803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.814 | 1.775 | 0.8327 | -2.053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 474.71973 | 1.004 | -1.154 | -0.9246 | -0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9816 | 0.04617 | -0.7611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7975 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5100 | -0.8614 | -1.064 | -0.2281 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.71973 | 91.32 | -5.354 | -0.9026 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4143 | 1.212 | 0.06176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7890 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.606 | 0.9656 | 0.6996 | 1.990 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.71973</span> | 91.32 | 0.004729 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009863 | 0.6021 | 1.212 | 0.06176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7890 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.606 | 0.9656 | 0.6996 | 1.990 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.021 | 1.236 | 0.1299 | -0.09158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3929 | 1.368 | -4.925 | 3.331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07142 | 0.08893 | -0.6522 | -2.634 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.639 | 1.780 | 0.7273 | -2.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 474.70040 | 1.001 | -1.155 | -0.9247 | -0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9826 | 0.04954 | -0.7634 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8825 | -0.7971 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5117 | -0.8624 | -1.064 | -0.2267 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.7004 | 91.10 | -5.355 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4139 | 1.214 | 0.06169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7893 | 0.7114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.604 | 0.9647 | 0.6992 | 1.991 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.7004</span> | 91.10 | 0.004724 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009861 | 0.6020 | 1.214 | 0.06169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7893 | 0.7114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.604 | 0.9647 | 0.6992 | 1.991 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.76 | 1.220 | -0.1617 | -0.06091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4007 | 1.415 | -5.116 | 3.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1298 | 0.07714 | -0.6701 | -2.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.670 | 1.748 | 0.7590 | -2.043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 474.65116 | 1.003 | -1.156 | -0.9246 | -0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9837 | 0.05321 | -0.7662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8825 | -0.7967 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5130 | -0.8617 | -1.065 | -0.2255 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.65116 | 91.32 | -5.356 | -0.9026 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4134 | 1.215 | 0.06161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7896 | 0.7116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.603 | 0.9653 | 0.6987 | 1.993 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.65116</span> | 91.32 | 0.004720 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009857 | 0.6019 | 1.215 | 0.06161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7896 | 0.7116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.603 | 0.9653 | 0.6987 | 1.993 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.462 | 1.239 | 0.1107 | -0.09136 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3915 | 1.348 | -5.441 | 3.268 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1113 | 0.02510 | -0.6252 | -2.485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.647 | 1.796 | 0.6587 | -2.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 474.63065 | 1.001 | -1.157 | -0.9247 | -0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9846 | 0.05678 | -0.7683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8825 | -0.7963 | -1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5148 | -0.8629 | -1.065 | -0.2241 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.63065 | 91.11 | -5.357 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4129 | 1.217 | 0.06155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7899 | 0.7131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.600 | 0.9642 | 0.6984 | 1.994 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.63065</span> | 91.11 | 0.004716 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009855 | 0.6018 | 1.217 | 0.06155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7899 | 0.7131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.600 | 0.9642 | 0.6984 | 1.994 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.93 | 1.220 | -0.1531 | -0.06288 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3983 | 1.394 | -5.436 | 3.113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1458 | 0.07621 | -0.8397 | -0.6848 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.501 | 1.690 | 0.6891 | -2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 474.58497 | 1.004 | -1.158 | -0.9246 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9857 | 0.06060 | -0.7708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8826 | -0.7958 | -1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5162 | -0.8624 | -1.065 | -0.2230 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.58497 | 91.34 | -5.358 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4125 | 1.218 | 0.06148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7902 | 0.7126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.599 | 0.9647 | 0.6980 | 1.996 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.58497</span> | 91.34 | 0.004711 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009852 | 0.6017 | 1.218 | 0.06148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7902 | 0.7126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.599 | 0.9647 | 0.6980 | 1.996 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.248 | 1.234 | 0.1371 | -0.09456 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3896 | 1.328 | -5.011 | 3.180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1110 | 0.004022 | -0.8103 | -0.4964 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.349 | 1.713 | 0.5705 | -2.061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 474.55760 | 1.002 | -1.159 | -0.9247 | -0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9867 | 0.06444 | -0.7734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8826 | -0.7952 | -1.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5178 | -0.8626 | -1.066 | -0.2215 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.5576 | 91.15 | -5.359 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4120 | 1.220 | 0.06140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7907 | 0.7122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.597 | 0.9645 | 0.6977 | 1.998 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.5576</span> | 91.15 | 0.004706 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009849 | 0.6016 | 1.220 | 0.06140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7907 | 0.7122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.597 | 0.9645 | 0.6977 | 1.998 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.86 | 1.219 | -0.1003 | -0.07615 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3954 | 1.369 | -4.929 | 3.171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1229 | 0.06540 | -0.8183 | -0.7141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.360 | 1.696 | 0.6359 | -2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 474.51619 | 1.004 | -1.160 | -0.9246 | -0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9878 | 0.06816 | -0.7761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8826 | -0.7946 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5193 | -0.8622 | -1.066 | -0.2202 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.51619 | 91.33 | -5.360 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4115 | 1.221 | 0.06132 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7911 | 0.7113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.595 | 0.9648 | 0.6972 | 1.999 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.51619</span> | 91.33 | 0.004702 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009846 | 0.6014 | 1.221 | 0.06132 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7911 | 0.7113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.595 | 0.9648 | 0.6972 | 1.999 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.413 | 1.225 | 0.1371 | -0.09620 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3880 | 1.314 | -5.554 | 3.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07604 | 0.008867 | -0.7931 | -0.6282 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.148 | 1.715 | 0.5273 | -2.052 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 474.48673 | 1.002 | -1.161 | -0.9247 | -0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9889 | 0.07224 | -0.7786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8826 | -0.7941 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5208 | -0.8625 | -1.067 | -0.2188 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.48673 | 91.17 | -5.361 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4110 | 1.223 | 0.06125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7915 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.593 | 0.9645 | 0.6969 | 2.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.48673</span> | 91.17 | 0.004697 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009843 | 0.6013 | 1.223 | 0.06125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7915 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.593 | 0.9645 | 0.6969 | 2.001 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.51 | 1.211 | -0.06554 | -0.07429 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3932 | 1.350 | -4.456 | 3.182 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08901 | 0.05354 | -0.5957 | -2.739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.160 | 1.696 | 0.5687 | -2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 474.45218 | 1.004 | -1.162 | -0.9246 | -0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9900 | 0.07590 | -0.7814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8826 | -0.7937 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5220 | -0.8620 | -1.067 | -0.2177 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.45218 | 91.40 | -5.362 | -0.9027 | -2.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4105 | 1.224 | 0.06117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7918 | 0.7111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.592 | 0.9650 | 0.6965 | 2.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.45218</span> | 91.40 | 0.004692 | 0.2885 | 0.1108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009840 | 0.6012 | 1.224 | 0.06117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7918 | 0.7111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.592 | 0.9650 | 0.6965 | 2.002 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.724 | 1.224 | 0.2009 | -0.1069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3834 | 1.279 | -5.556 | 3.324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1101 | -0.01912 | -0.5638 | -2.553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.043 | 1.731 | 0.4140 | -2.044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 474.41257 | 1.003 | -1.163 | -0.9246 | -0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9913 | 0.07979 | -0.7844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7935 | -1.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5231 | -0.8612 | -1.068 | -0.2167 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.41257 | 91.25 | -5.363 | -0.9026 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4099 | 1.226 | 0.06108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7919 | 0.7118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.591 | 0.9658 | 0.6961 | 2.004 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.41257</span> | 91.25 | 0.004687 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009836 | 0.6011 | 1.226 | 0.06108 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7919 | 0.7118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.591 | 0.9658 | 0.6961 | 2.004 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.208 | 1.213 | 0.03978 | -0.08693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3876 | 1.303 | -5.023 | 3.218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1347 | 0.02311 | -0.7771 | -0.6556 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.056 | 1.822 | 0.4520 | -2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 474.39271 | 1.005 | -1.164 | -0.9246 | -0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9922 | 0.08348 | -0.7867 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7600 | -0.8825 | -0.7930 | -1.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5246 | -0.8625 | -1.068 | -0.2152 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.39271 | 91.47 | -5.364 | -0.9027 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4094 | 1.228 | 0.06101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7923 | 0.7123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.589 | 0.9645 | 0.6958 | 2.005 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.39271</span> | 91.47 | 0.004683 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009833 | 0.6010 | 1.228 | 0.06101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7923 | 0.7123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.589 | 0.9645 | 0.6958 | 2.005 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.86 | 1.227 | 0.2807 | -0.1163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3793 | 1.243 | -5.494 | 3.329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09368 | 0.01293 | -0.5149 | -2.407 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.979 | 1.686 | 0.3308 | -2.044 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 474.34538 | 1.003 | -1.165 | -0.9247 | -0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9934 | 0.08718 | -0.7897 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7926 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5258 | -0.8620 | -1.068 | -0.2141 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.34538 | 91.27 | -5.365 | -0.9027 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4089 | 1.229 | 0.06093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7926 | 0.7117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.587 | 0.9650 | 0.6954 | 2.007 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.34538</span> | 91.27 | 0.004677 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009830 | 0.6008 | 1.229 | 0.06093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7926 | 0.7117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.587 | 0.9650 | 0.6954 | 2.007 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.345 | 1.210 | 0.04189 | -0.08986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3855 | 1.284 | -5.145 | 3.218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1284 | 0.01309 | -0.7466 | -0.6536 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.964 | 1.743 | 0.3816 | -2.008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 474.31834 | 1.005 | -1.166 | -0.9247 | -0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9944 | 0.09109 | -0.7921 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7600 | -0.8825 | -0.7920 | -1.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5273 | -0.8633 | -1.069 | -0.2126 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.31834 | 91.43 | -5.366 | -0.9027 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4085 | 1.231 | 0.06086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7930 | 0.7121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.586 | 0.9638 | 0.6952 | 2.008 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.31834</span> | 91.43 | 0.004673 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009827 | 0.6007 | 1.231 | 0.06086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7930 | 0.7121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.586 | 0.9638 | 0.6952 | 2.008 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.13 | 1.219 | 0.2312 | -0.1125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3787 | 1.238 | -5.317 | 3.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08361 | -0.02599 | -0.7000 | -0.4940 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.837 | 1.637 | 0.3211 | -2.028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 474.27833 | 1.003 | -1.167 | -0.9247 | -0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9955 | 0.09487 | -0.7949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7915 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5286 | -0.8630 | -1.069 | -0.2114 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.27833 | 91.25 | -5.367 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4080 | 1.232 | 0.06078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7934 | 0.7111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9640 | 0.6948 | 2.010 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.27833</span> | 91.25 | 0.004668 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009824 | 0.6006 | 1.232 | 0.06078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7934 | 0.7111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9640 | 0.6948 | 2.010 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.145 | 1.202 | 0.02355 | -0.08919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3842 | 1.275 | -5.102 | 3.189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1071 | 0.01700 | -0.7283 | -0.7209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.776 | 1.686 | 0.3249 | -1.982 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 474.25305 | 1.005 | -1.168 | -0.9247 | -0.9367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9965 | 0.09878 | -0.7975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7909 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5300 | -0.8636 | -1.069 | -0.2100 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.25305 | 91.44 | -5.368 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4075 | 1.234 | 0.06070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7938 | 0.7109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.583 | 0.9635 | 0.6946 | 2.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.25305</span> | 91.44 | 0.004663 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009821 | 0.6005 | 1.234 | 0.06070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7938 | 0.7109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.583 | 0.9635 | 0.6946 | 2.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.11 | 1.213 | 0.2527 | -0.1161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3767 | 1.219 | -5.003 | 3.213 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09270 | -0.04298 | -0.4814 | -2.533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | 1.613 | 0.2495 | -2.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 474.21254 | 1.003 | -1.169 | -0.9248 | -0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9977 | 0.1025 | -0.8005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8824 | -0.7906 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5311 | -0.8630 | -1.070 | -0.2089 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.21254 | 91.24 | -5.369 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4069 | 1.236 | 0.06062 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7941 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.581 | 0.9641 | 0.6942 | 2.013 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.21254</span> | 91.24 | 0.004658 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009817 | 0.6003 | 1.236 | 0.06062 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7941 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.581 | 0.9641 | 0.6942 | 2.013 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.267 | 1.195 | 0.01760 | -0.08987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3825 | 1.260 | -5.272 | 3.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1336 | 0.009843 | -0.5186 | -2.706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.727 | 1.652 | 0.2904 | -1.976 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 474.18171 | 1.004 | -1.170 | -0.9247 | -0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9989 | 0.1065 | -0.8033 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8823 | -0.7904 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5322 | -0.8627 | -1.070 | -0.2078 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.18171 | 91.41 | -5.370 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4064 | 1.237 | 0.06054 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7942 | 0.7112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.580 | 0.9644 | 0.6939 | 2.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.18171</span> | 91.41 | 0.004653 | 0.2885 | 0.1109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009814 | 0.6002 | 1.237 | 0.06054 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7942 | 0.7112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.580 | 0.9644 | 0.6939 | 2.014 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.716 | 1.206 | 0.2113 | -0.1128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3755 | 1.207 | -5.399 | 3.226 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09670 | -0.03459 | -0.6713 | -0.5638 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 1.687 | 0.2005 | -1.998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 474.14509 | 1.003 | -1.171 | -0.9248 | -0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.000 | 0.1105 | -0.8061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8822 | -0.7900 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5333 | -0.8621 | -1.071 | -0.2068 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.14509 | 91.25 | -5.371 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4059 | 1.239 | 0.06045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05825 | 0.7945 | 0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.579 | 0.9649 | 0.6936 | 2.015 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.14509</span> | 91.25 | 0.004648 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009811 | 0.6001 | 1.239 | 0.06045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05825 | 0.7945 | 0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.579 | 0.9649 | 0.6936 | 2.015 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.280 | 1.192 | 0.02321 | -0.09129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3799 | 1.239 | -5.339 | 3.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1074 | 0.06181 | -0.4875 | -2.680 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.648 | 1.743 | 0.2195 | -1.955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 474.11542 | 1.005 | -1.172 | -0.9248 | -0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.001 | 0.1146 | -0.8089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7603 | -0.8821 | -0.7897 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5344 | -0.8621 | -1.071 | -0.2057 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.11542 | 91.42 | -5.372 | -0.9028 | -2.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4054 | 1.241 | 0.06037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7947 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.577 | 0.9649 | 0.6934 | 2.017 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.11542</span> | 91.42 | 0.004643 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009807 | 0.6000 | 1.241 | 0.06037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7947 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.577 | 0.9649 | 0.6934 | 2.017 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.52 | 1.202 | 0.2258 | -0.1162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3725 | 1.186 | -5.381 | 3.222 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1104 | -0.04157 | -0.6550 | -0.5841 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.505 | 1.701 | 0.1753 | -1.993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 474.07794 | 1.003 | -1.173 | -0.9248 | -0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.002 | 0.1187 | -0.8117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7604 | -0.8821 | -0.7895 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5355 | -0.8615 | -1.071 | -0.2048 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.07794 | 91.25 | -5.373 | -0.9028 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4048 | 1.242 | 0.06029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7949 | 0.7104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.576 | 0.9655 | 0.6932 | 2.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.07794</span> | 91.25 | 0.004638 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009804 | 0.5999 | 1.242 | 0.06029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7949 | 0.7104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.576 | 0.9655 | 0.6932 | 2.018 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.801 | 1.188 | 0.03689 | -0.09236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3785 | 1.221 | -5.368 | 3.104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1066 | 0.003449 | -0.6711 | -0.7398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 1.803 | 0.1884 | -1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 474.04951 | 1.005 | -1.175 | -0.9248 | -0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.003 | 0.1228 | -0.8144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7604 | -0.8820 | -0.7890 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5367 | -0.8618 | -1.071 | -0.2036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.04951 | 91.43 | -5.375 | -0.9028 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4044 | 1.244 | 0.06021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7952 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.575 | 0.9652 | 0.6930 | 2.019 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.04951</span> | 91.43 | 0.004633 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009801 | 0.5997 | 1.244 | 0.06021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7952 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.575 | 0.9652 | 0.6930 | 2.019 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.86 | 1.196 | 0.2377 | -0.1190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3700 | 1.169 | -5.399 | 3.259 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09645 | -0.03914 | -0.4400 | -2.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.421 | 1.705 | 0.1351 | -1.978 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 474.01246 | 1.003 | -1.176 | -0.9249 | -0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.004 | 0.1268 | -0.8173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7606 | -0.8819 | -0.7888 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5377 | -0.8613 | -1.072 | -0.2028 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.01246 | 91.25 | -5.376 | -0.9029 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4039 | 1.246 | 0.06013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05825 | 0.7954 | 0.7098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.573 | 0.9657 | 0.6927 | 2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.01246</span> | 91.25 | 0.004628 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009798 | 0.5996 | 1.246 | 0.06013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05825 | 0.7954 | 0.7098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.573 | 0.9657 | 0.6927 | 2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.724 | 1.179 | 0.03043 | -0.09493 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3750 | 1.206 | -5.283 | 3.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09863 | -0.01543 | -0.6573 | -0.7980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.377 | 1.778 | 0.1578 | -1.944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 473.98155 | 1.005 | -1.177 | -0.9249 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.005 | 0.1310 | -0.8202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7607 | -0.8818 | -0.7885 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5387 | -0.8611 | -1.072 | -0.2018 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.98155 | 91.42 | -5.377 | -0.9029 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4034 | 1.247 | 0.06004 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05826 | 0.7956 | 0.7095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9659 | 0.6925 | 2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.98155</span> | 91.42 | 0.004623 | 0.2885 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009794 | 0.5995 | 1.247 | 0.06004 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05826 | 0.7956 | 0.7095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9659 | 0.6925 | 2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.125 | 1.189 | 0.2215 | -0.1183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3680 | 1.157 | -5.346 | 3.214 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06695 | -0.05805 | -0.6245 | -0.6678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.365 | 1.770 | 0.07348 | -1.960 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 473.94647 | 1.003 | -1.178 | -0.9250 | -0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.007 | 0.1350 | -0.8231 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7608 | -0.8817 | -0.7881 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5397 | -0.8608 | -1.072 | -0.2009 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.94647 | 91.26 | -5.378 | -0.9030 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4029 | 1.249 | 0.05996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7959 | 0.7086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.571 | 0.9661 | 0.6923 | 2.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.94647</span> | 91.26 | 0.004618 | 0.2884 | 0.1110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009791 | 0.5994 | 1.249 | 0.05996 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7959 | 0.7086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.571 | 0.9661 | 0.6923 | 2.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.271 | 1.174 | 0.04603 | -0.09766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3725 | 1.188 | -5.320 | 3.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09768 | -0.01918 | -0.6378 | -0.8469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.360 | 1.825 | 0.08453 | -1.920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 473.91708 | 1.005 | -1.179 | -0.9250 | -0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.008 | 0.1391 | -0.8259 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7609 | -0.8816 | -0.7877 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5408 | -0.8610 | -1.072 | -0.1999 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.91708 | 91.43 | -5.379 | -0.9030 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4024 | 1.251 | 0.05988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7962 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.570 | 0.9660 | 0.6921 | 2.024 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.91708</span> | 91.43 | 0.004613 | 0.2884 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009788 | 0.5993 | 1.251 | 0.05988 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7962 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.570 | 0.9660 | 0.6921 | 2.024 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.919 | 1.183 | 0.2388 | -0.1221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3649 | 1.138 | -5.295 | 3.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05759 | -0.06746 | -0.6018 | -0.7458 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.218 | 1.797 | 0.02666 | -1.950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 473.88166 | 1.003 | -1.180 | -0.9251 | -0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.009 | 0.1432 | -0.8289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7611 | -0.8814 | -0.7874 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5418 | -0.8607 | -1.072 | -0.1991 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.88166 | 91.26 | -5.380 | -0.9031 | -2.198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4019 | 1.252 | 0.05979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7964 | 0.7073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 0.9662 | 0.6919 | 2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.88166</span> | 91.26 | 0.004608 | 0.2884 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009785 | 0.5991 | 1.252 | 0.05979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7964 | 0.7073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 0.9662 | 0.6919 | 2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.370 | 1.167 | 0.05346 | -0.09978 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3701 | 1.174 | -5.172 | 3.105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07011 | -0.02516 | -0.4239 | -2.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.187 | 1.854 | 0.07395 | -1.907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 473.85215 | 1.005 | -1.181 | -0.9251 | -0.9350 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.010 | 0.1472 | -0.8318 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7612 | -0.8813 | -0.7872 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5427 | -0.8608 | -1.073 | -0.1983 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.85215 | 91.44 | -5.381 | -0.9031 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4014 | 1.254 | 0.05971 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7965 | 0.7078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9662 | 0.6918 | 2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.85215</span> | 91.44 | 0.004603 | 0.2884 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009781 | 0.5990 | 1.254 | 0.05971 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7965 | 0.7078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9662 | 0.6918 | 2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.42 | 1.179 | 0.2474 | -0.1240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3627 | 1.120 | -5.345 | 3.221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07960 | -0.04998 | -0.3836 | -2.755 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.094 | 1.797 | -0.01014 | -1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 473.81514 | 1.003 | -1.182 | -0.9251 | -0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.011 | 0.1513 | -0.8349 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7614 | -0.8810 | -0.7873 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5432 | -0.8601 | -1.073 | -0.1979 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.81514 | 91.27 | -5.382 | -0.9031 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.4008 | 1.256 | 0.05962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05828 | 0.7964 | 0.7084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9669 | 0.6916 | 2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.81514</span> | 91.27 | 0.004598 | 0.2884 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009778 | 0.5989 | 1.256 | 0.05962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05828 | 0.7964 | 0.7084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9669 | 0.6916 | 2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.811 | 1.166 | 0.05684 | -0.1019 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3663 | 1.150 | -5.276 | 3.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06818 | -0.03474 | -0.4125 | -2.836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.158 | 1.851 | 0.03258 | -1.914 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 473.78884 | 1.005 | -1.183 | -0.9252 | -0.9346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.012 | 0.1554 | -0.8377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7615 | -0.8808 | -0.7873 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | -0.8602 | -1.073 | -0.1971 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.78884 | 91.46 | -5.383 | -0.9031 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.4003 | 1.257 | 0.05954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05829 | 0.7965 | 0.7095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.566 | 0.9667 | 0.6915 | 2.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.78884</span> | 91.46 | 0.004593 | 0.2884 | 0.1111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009775 | 0.5988 | 1.257 | 0.05954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05829 | 0.7965 | 0.7095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.566 | 0.9667 | 0.6915 | 2.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.26 | 1.178 | 0.2628 | -0.1282 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3579 | 1.094 | -5.180 | 3.234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08932 | -0.09780 | -0.5652 | -0.6340 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.031 | 1.841 | -0.06209 | -1.938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 473.75065 | 1.003 | -1.184 | -0.9252 | -0.9344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.013 | 0.1594 | -0.8407 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7617 | -0.8806 | -0.7872 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5446 | -0.8597 | -1.073 | -0.1966 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.75065 | 91.27 | -5.384 | -0.9032 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.3998 | 1.259 | 0.05945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8769 | 0.05829 | 0.7965 | 0.7092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9672 | 0.6914 | 2.028 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.75065</span> | 91.27 | 0.004588 | 0.2884 | 0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009772 | 0.5986 | 1.259 | 0.05945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8769 | 0.05829 | 0.7965 | 0.7092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9672 | 0.6914 | 2.028 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.250 | 1.164 | 0.05078 | -0.1019 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3635 | 1.132 | -5.308 | 3.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09569 | -0.05602 | -0.5891 | -0.8121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.074 | 1.883 | 0.002586 | -1.906 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 473.72028 | 1.005 | -1.185 | -0.9252 | -0.9343 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.014 | 0.1635 | -0.8437 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7618 | -0.8804 | -0.7870 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5455 | -0.8599 | -1.073 | -0.1958 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.72028 | 91.43 | -5.385 | -0.9032 | -2.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3993 | 1.261 | 0.05936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05830 | 0.7967 | 0.7088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.564 | 0.9671 | 0.6912 | 2.029 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.72028</span> | 91.43 | 0.004583 | 0.2884 | 0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009768 | 0.5985 | 1.261 | 0.05936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05830 | 0.7967 | 0.7088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.564 | 0.9671 | 0.6912 | 2.029 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.975 | 1.171 | 0.2290 | -0.1246 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3563 | 1.085 | -5.320 | 3.173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08707 | -0.1016 | -0.5561 | -0.7117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9536 | 1.850 | -0.07963 | -1.922 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 473.68600 | 1.003 | -1.186 | -0.9253 | -0.9341 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.015 | 0.1676 | -0.8467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7620 | -0.8801 | -0.7868 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5463 | -0.8596 | -1.073 | -0.1952 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.686 | 91.28 | -5.386 | -0.9033 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3989 | 1.263 | 0.05928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05831 | 0.7968 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 0.9673 | 0.6911 | 2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.686</span> | 91.28 | 0.004578 | 0.2884 | 0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009765 | 0.5984 | 1.263 | 0.05928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05831 | 0.7968 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 0.9673 | 0.6911 | 2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.608 | 1.155 | 0.05506 | -0.1036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3607 | 1.118 | -5.212 | 3.031 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08611 | -0.04336 | -0.3798 | -2.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.093 | 1.880 | -0.02731 | -1.896 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 473.65599 | 1.005 | -1.188 | -0.9253 | -0.9339 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -1.016 | 0.1718 | -0.8497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7621 | -0.8799 | -0.7868 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5471 | -0.8595 | -1.074 | -0.1946 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.65599 | 91.44 | -5.388 | -0.9033 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3984 | 1.264 | 0.05919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8767 | 0.05831 | 0.7968 | 0.7087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9674 | 0.6910 | 2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.65599</span> | 91.44 | 0.004573 | 0.2884 | 0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009762 | 0.5983 | 1.264 | 0.05919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8767 | 0.05831 | 0.7968 | 0.7087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9674 | 0.6910 | 2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.720 | 1.170 | 0.2444 | -0.1229 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3557 | 1.067 | -5.275 | 3.173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07850 | -0.1042 | -0.5348 | -0.6844 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9479 | 1.915 | -0.1018 | -1.917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 473.62083 | 1.003 | -1.189 | -0.9254 | -0.9337 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -1.017 | 0.1759 | -0.8528 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7623 | -0.8795 | -0.7869 | -1.089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5477 | -0.8591 | -1.074 | -0.1942 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.62083 | 91.28 | -5.389 | -0.9033 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3979 | 1.266 | 0.05910 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05832 | 0.7968 | 0.7085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9678 | 0.6909 | 2.031 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.62083</span> | 91.28 | 0.004568 | 0.2884 | 0.1112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009758 | 0.5982 | 1.266 | 0.05910 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05832 | 0.7968 | 0.7085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9678 | 0.6909 | 2.031 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.323 | 1.153 | 0.05982 | -0.1053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3572 | 1.098 | -4.702 | 3.058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1117 | -0.04281 | -0.5573 | -0.7999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.039 | 1.912 | -0.05974 | -1.890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 473.59326 | 1.005 | -1.190 | -0.9254 | -0.9335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.019 | 0.1798 | -0.8560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7624 | -0.8793 | -0.7867 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5486 | -0.8595 | -1.074 | -0.1934 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.59326 | 91.46 | -5.390 | -0.9034 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3974 | 1.268 | 0.05901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05833 | 0.7969 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9674 | 0.6908 | 2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.59326</span> | 91.46 | 0.004562 | 0.2884 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009755 | 0.5981 | 1.268 | 0.05901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05833 | 0.7969 | 0.7081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9674 | 0.6908 | 2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.25 | 1.162 | 0.2586 | -0.1299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3499 | 1.048 | -5.229 | 3.126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05642 | -0.09930 | -0.3252 | -2.718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8202 | 1.876 | -0.1477 | -1.910 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 473.55541 | 1.003 | -1.191 | -0.9255 | -0.9333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.020 | 0.1836 | -0.8595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8789 | -0.7868 | -1.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5492 | -0.8592 | -1.074 | -0.1932 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.55541 | 91.31 | -5.391 | -0.9034 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3968 | 1.269 | 0.05891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7968 | 0.7080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9677 | 0.6906 | 2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.55541</span> | 91.31 | 0.004557 | 0.2883 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009751 | 0.5979 | 1.269 | 0.05891 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7968 | 0.7080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9677 | 0.6906 | 2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.062 | 1.149 | 0.09224 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3525 | 1.070 | -5.098 | 2.994 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1095 | -0.04877 | -0.3504 | -2.828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8255 | 1.898 | -0.1147 | -1.889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 473.53708 | 1.006 | -1.192 | -0.9256 | -0.9332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.021 | 0.1873 | -0.8616 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7625 | -0.8789 | -0.7866 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5498 | -0.8606 | -1.074 | -0.1918 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.53708 | 91.52 | -5.392 | -0.9035 | -2.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3964 | 1.271 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7970 | 0.7099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9664 | 0.6907 | 2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.53708</span> | 91.52 | 0.004553 | 0.2883 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009749 | 0.5978 | 1.271 | 0.05884 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7970 | 0.7099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9664 | 0.6907 | 2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.25 | 1.165 | 0.3077 | -0.1378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3448 | 1.019 | -5.264 | 3.150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09278 | -0.1366 | -0.2969 | -2.557 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.781 | -0.1828 | -1.909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 473.49312 | 1.003 | -1.193 | -0.9256 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.022 | 0.1912 | -0.8647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8785 | -0.7869 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5501 | -0.8598 | -1.074 | -0.1918 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.49312 | 91.32 | -5.393 | -0.9035 | -2.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3959 | 1.272 | 0.05875 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7967 | 0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9671 | 0.6906 | 2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.49312</span> | 91.32 | 0.004547 | 0.2883 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009745 | 0.5977 | 1.272 | 0.05875 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7967 | 0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9671 | 0.6906 | 2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.793 | 1.150 | 0.08391 | -0.1095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3500 | 1.057 | -5.154 | 2.847 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07414 | -0.06025 | -0.5244 | -0.6779 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8291 | 1.867 | -0.1201 | -1.880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 473.47390 | 1.006 | -1.194 | -0.9256 | -0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.022 | 0.1953 | -0.8670 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8785 | -0.7865 | -1.086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5507 | -0.8613 | -1.074 | -0.1903 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.4739 | 91.52 | -5.394 | -0.9036 | -2.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3955 | 1.274 | 0.05869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7970 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9657 | 0.6907 | 2.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4739</span> | 91.52 | 0.004543 | 0.2883 | 0.1113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009743 | 0.5976 | 1.274 | 0.05869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7970 | 0.7110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9657 | 0.6907 | 2.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.82 | 1.163 | 0.3026 | -0.1376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3423 | 1.007 | -4.821 | 3.176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06207 | -0.1161 | -0.4712 | -0.4774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7015 | 1.725 | -0.1877 | -1.896 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 473.43080 | 1.003 | -1.195 | -0.9257 | -0.9326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.024 | 0.1991 | -0.8700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7628 | -0.8781 | -0.7866 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5513 | -0.8608 | -1.074 | -0.1899 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.4308 | 91.31 | -5.395 | -0.9036 | -2.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3950 | 1.276 | 0.05860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05836 | 0.7970 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.557 | 0.9662 | 0.6906 | 2.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4308</span> | 91.31 | 0.004538 | 0.2883 | 0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009739 | 0.5975 | 1.276 | 0.05860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05836 | 0.7970 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.557 | 0.9662 | 0.6906 | 2.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.611 | 1.145 | 0.07564 | -0.1091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3478 | 1.048 | -5.196 | 2.853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07176 | -0.06153 | -0.5100 | -0.6862 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7701 | 1.783 | -0.1204 | -1.866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 473.40390 | 1.005 | -1.196 | -0.9258 | -0.9324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.025 | 0.2034 | -0.8728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7629 | -0.8779 | -0.7864 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5520 | -0.8612 | -1.074 | -0.1890 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.4039 | 91.48 | -5.396 | -0.9037 | -2.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3946 | 1.277 | 0.05852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05837 | 0.7971 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9658 | 0.6906 | 2.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4039</span> | 91.48 | 0.004533 | 0.2883 | 0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009736 | 0.5974 | 1.277 | 0.05852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05837 | 0.7971 | 0.7105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9658 | 0.6906 | 2.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.82 | 1.154 | 0.2542 | -0.1321 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3410 | 1.002 | -5.150 | 3.097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04820 | -0.1059 | -0.4698 | -0.5387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 1.733 | -0.1906 | -1.879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 473.36686 | 1.003 | -1.198 | -0.9258 | -0.9322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.026 | 0.2076 | -0.8758 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7631 | -0.8776 | -0.7865 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5525 | -0.8606 | -1.074 | -0.1886 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.36686 | 91.32 | -5.398 | -0.9037 | -2.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3941 | 1.279 | 0.05843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7970 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9664 | 0.6905 | 2.038 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.36686</span> | 91.32 | 0.004527 | 0.2883 | 0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009733 | 0.5973 | 1.279 | 0.05843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7970 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9664 | 0.6905 | 2.038 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.686 | 1.139 | 0.08028 | -0.1103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3450 | 1.034 | -5.059 | 2.983 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07022 | -0.06541 | -0.4954 | -0.7148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6839 | 1.782 | -0.1353 | -1.853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 473.34117 | 1.005 | -1.199 | -0.9259 | -0.9321 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.027 | 0.2118 | -0.8787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7632 | -0.8774 | -0.7864 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5531 | -0.8611 | -1.074 | -0.1877 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.34117 | 91.49 | -5.399 | -0.9038 | -2.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3936 | 1.281 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7971 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9659 | 0.6904 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.34117</span> | 91.49 | 0.004522 | 0.2883 | 0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009730 | 0.5972 | 1.281 | 0.05835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7971 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9659 | 0.6904 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.62 | 1.149 | 0.2679 | -0.1346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3379 | 0.9875 | -5.147 | 2.965 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07400 | -0.1145 | -0.4542 | -0.5455 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6283 | 1.734 | -0.2097 | -1.869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 473.30326 | 1.004 | -1.200 | -0.9259 | -0.9318 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.028 | 0.2159 | -0.8818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7634 | -0.8771 | -0.7865 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5535 | -0.8604 | -1.074 | -0.1874 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.30326 | 91.32 | -5.400 | -0.9038 | -2.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3932 | 1.283 | 0.05826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05839 | 0.7970 | 0.7096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9665 | 0.6903 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.30326</span> | 91.32 | 0.004517 | 0.2883 | 0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009726 | 0.5970 | 1.283 | 0.05826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05839 | 0.7970 | 0.7096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9665 | 0.6903 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.609 | 1.134 | 0.08636 | -0.1114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3423 | 1.018 | -5.228 | 2.880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1079 | -0.06580 | -0.2896 | -2.686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6917 | 1.801 | -0.1599 | -1.842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 473.27616 | 1.005 | -1.201 | -0.9260 | -0.9316 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.029 | 0.2202 | -0.8845 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7634 | -0.8768 | -0.7866 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5540 | -0.8607 | -1.074 | -0.1867 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.27616 | 91.48 | -5.401 | -0.9039 | -2.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3927 | 1.284 | 0.05818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05840 | 0.7970 | 0.7107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9663 | 0.6904 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.27616</span> | 91.48 | 0.004512 | 0.2883 | 0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009723 | 0.5969 | 1.284 | 0.05818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05840 | 0.7970 | 0.7107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9663 | 0.6904 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.44 | 1.145 | 0.2516 | -0.1333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3351 | 0.9744 | -4.753 | 3.090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05028 | -0.1148 | -0.4450 | -0.5198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5573 | 1.743 | -0.2240 | -1.858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 473.24283 | 1.003 | -1.202 | -0.9260 | -0.9314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.030 | 0.2240 | -0.8877 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7636 | -0.8764 | -0.7870 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5543 | -0.8601 | -1.074 | -0.1866 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.24283 | 91.29 | -5.402 | -0.9039 | -2.194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3922 | 1.286 | 0.05809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8761 | 0.05841 | 0.7967 | 0.7107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9668 | 0.6903 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.24283</span> | 91.29 | 0.004506 | 0.2882 | 0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009720 | 0.5968 | 1.286 | 0.05809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8761 | 0.05841 | 0.7967 | 0.7107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9668 | 0.6903 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.383 | 1.129 | 0.03939 | -0.1057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3410 | 1.013 | -4.733 | 2.907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07460 | -0.06623 | -0.4732 | -0.6761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6495 | 1.823 | -0.1637 | -1.832 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 473.20973 | 1.005 | -1.204 | -0.9260 | -0.9311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.031 | 0.2279 | -0.8912 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7638 | -0.8760 | -0.7872 | -1.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.8600 | -1.075 | -0.1862 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.20973 | 91.43 | -5.404 | -0.9039 | -2.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3917 | 1.288 | 0.05799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8760 | 0.05843 | 0.7966 | 0.7102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.553 | 0.9669 | 0.6900 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.20973</span> | 91.43 | 0.004500 | 0.2882 | 0.1115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009716 | 0.5967 | 1.288 | 0.05799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8760 | 0.05843 | 0.7966 | 0.7102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.553 | 0.9669 | 0.6900 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 473.17178 | 1.005 | -1.205 | -0.9261 | -0.9307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -1.032 | 0.2326 | -0.8959 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7641 | -0.8754 | -0.7876 | -1.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5554 | -0.8593 | -1.075 | -0.1863 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.17178 | 91.43 | -5.405 | -0.9040 | -2.193 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3910 | 1.289 | 0.05785 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8759 | 0.05844 | 0.7963 | 0.7092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.552 | 0.9676 | 0.6896 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.17178</span> | 91.43 | 0.004492 | 0.2882 | 0.1116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009711 | 0.5965 | 1.289 | 0.05785 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8759 | 0.05844 | 0.7963 | 0.7092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.552 | 0.9676 | 0.6896 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 472.97479 | 1.005 | -1.215 | -0.9262 | -0.9287 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -1.041 | 0.2575 | -0.9212 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7657 | -0.8720 | -0.7899 | -1.094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5585 | -0.8552 | -1.078 | -0.1866 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.97479 | 91.45 | -5.415 | -0.9041 | -2.191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.3872 | 1.300 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8752 | 0.05854 | 0.7946 | 0.7037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.549 | 0.9715 | 0.6874 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.97479</span> | 91.45 | 0.004449 | 0.2882 | 0.1118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009685 | 0.5956 | 1.300 | 0.05712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8752 | 0.05854 | 0.7946 | 0.7037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.549 | 0.9715 | 0.6874 | 2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 472.26932 | 1.006 | -1.253 | -0.9268 | -0.9205 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -1.074 | 0.3572 | -1.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7723 | -0.8583 | -0.7991 | -1.118 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5709 | -0.8392 | -1.088 | -0.1877 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.26932 | 91.55 | -5.453 | -0.9046 | -2.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.648 | 0.3719 | 1.341 | 0.05419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8725 | 0.05894 | 0.7878 | 0.6819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.534 | 0.9868 | 0.6787 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.26932</span> | 91.55 | 0.004282 | 0.2881 | 0.1127 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009582 | 0.5919 | 1.341 | 0.05419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8725 | 0.05894 | 0.7878 | 0.6819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.534 | 0.9868 | 0.6787 | 2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 470.90347 | 1.012 | -1.408 | -0.9286 | -0.8872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.078 | -1.207 | 0.7550 | -1.427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7985 | -0.8024 | -0.8343 | -1.204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6170 | -0.7722 | -1.128 | -0.1957 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 470.90347 | 92.06 | -5.608 | -0.9062 | -2.150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.691 | 0.3105 | 1.506 | 0.04245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8616 | 0.06056 | 0.7621 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.051 | 0.6438 | 2.029 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.90347</span> | 92.06 | 0.003670 | 0.2878 | 0.1165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009180 | 0.5770 | 1.506 | 0.04245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8616 | 0.06056 | 0.7621 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.051 | 0.6438 | 2.029 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.46 | 0.7178 | 1.137 | -0.2842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06515 | -1.058 | -6.810 | -2.325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1903 | -0.6630 | 1.424 | -9.046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.659 | 8.235 | -7.307 | -1.506 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 469.55066 | 1.016 | -1.623 | -0.9529 | -0.8214 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.136 | -1.353 | 1.295 | -1.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8595 | -0.6716 | -0.9513 | -1.204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7087 | -0.8316 | -0.9499 | -0.4083 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.55066 | 92.47 | -5.823 | -0.9279 | -2.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.749 | 0.2437 | 1.731 | 0.02949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.06435 | 0.6766 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.371 | 0.9940 | 0.7978 | 1.771 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.55066</span> | 92.47 | 0.002960 | 0.2834 | 0.1245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008661 | 0.5606 | 1.731 | 0.02949 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.06435 | 0.6766 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.371 | 0.9940 | 0.7978 | 1.771 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.003 | 0.4823 | 0.6025 | -0.2481 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.135 | 0.1015 | -5.875 | -8.309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8363 | -0.7839 | 1.711 | -6.097 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.755 | 1.794 | 4.040 | -0.5408 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 471.32255 | 1.022 | -1.880 | -1.043 | -0.7426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.107 | -1.512 | 1.956 | -1.964 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9773 | -0.5429 | -1.097 | -1.122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6469 | -0.5662 | -0.9027 | -0.4752 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 471.32255 | 93.00 | -6.080 | -1.008 | -2.005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.719 | 0.1705 | 2.005 | 0.02687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7874 | 0.06809 | 0.5704 | 0.6787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.444 | 1.248 | 0.8385 | 1.690 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 471.32255</span> | 93.00 | 0.002289 | 0.2674 | 0.1347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008922 | 0.5425 | 2.005 | 0.02687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7874 | 0.06809 | 0.5704 | 0.6787 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.444 | 1.248 | 0.8385 | 1.690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 468.82475 | 1.022 | -1.709 | -0.9836 | -0.7948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.126 | -1.406 | 1.521 | -1.898 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8984 | -0.6279 | -1.001 | -1.172 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6845 | -0.7440 | -0.9371 | -0.4303 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.82475 | 92.98 | -5.909 | -0.9551 | -2.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.738 | 0.2191 | 1.824 | 0.02879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8201 | 0.06562 | 0.6400 | 0.6333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.400 | 1.078 | 0.8088 | 1.744 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.82475</span> | 92.98 | 0.002714 | 0.2779 | 0.1278 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008755 | 0.5546 | 1.824 | 0.02879 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8201 | 0.06562 | 0.6400 | 0.6333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.400 | 1.078 | 0.8088 | 1.744 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.86 | 0.3767 | -0.09575 | -0.1893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.313 | -0.2132 | -3.864 | -4.927 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.292 | -1.079 | -0.1017 | -3.329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.248 | 8.116 | 3.916 | -0.3530 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 467.75171 | 1.017 | -1.816 | -0.9824 | -0.7623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.067 | -1.470 | 1.678 | -1.962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9501 | -0.5667 | -0.9995 | -1.140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5909 | -0.8204 | -1.012 | -0.4878 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.75171 | 92.51 | -6.016 | -0.9541 | -2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.679 | 0.1896 | 1.889 | 0.02693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7987 | 0.06740 | 0.6413 | 0.6622 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | 1.005 | 0.7438 | 1.674 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.75171</span> | 92.51 | 0.002440 | 0.2781 | 0.1320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009285 | 0.5473 | 1.889 | 0.02693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7987 | 0.06740 | 0.6413 | 0.6622 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | 1.005 | 0.7438 | 1.674 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.72 | 0.1617 | -0.2966 | 0.1391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7722 | -0.6625 | -3.136 | -6.222 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.617 | -0.9189 | -0.2811 | -3.105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05355 | 2.320 | -3.473 | -2.160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 467.28745 | 1.018 | -1.902 | -0.9107 | -0.7577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -1.517 | 1.777 | -1.860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8874 | -0.4787 | -0.8826 | -1.170 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6199 | -0.8544 | -0.9952 | -0.3962 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.28745 | 92.66 | -6.102 | -0.8902 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1682 | 1.931 | 0.02990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8247 | 0.06995 | 0.7268 | 0.6357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7587 | 1.785 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.28745</span> | 92.66 | 0.002239 | 0.2911 | 0.1327 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8247 | 0.06995 | 0.7268 | 0.6357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7587 | 1.785 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.75 | 0.1003 | 2.571 | 0.1450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5415 | -1.471 | -1.062 | -1.774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.363 | 0.7539 | 2.182 | -3.357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.337 | 0.2346 | -1.234 | -0.8531 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 469.68385 | 0.9954 | -1.950 | -1.032 | -0.7900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8810 | -1.433 | 1.783 | -1.785 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9418 | -0.5114 | -0.9107 | -1.204 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6798 | -0.8966 | -1.014 | -0.2565 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.68385 | 90.58 | -6.150 | -0.9984 | -2.052 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.493 | 0.2066 | 1.933 | 0.03207 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8021 | 0.06900 | 0.7062 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.405 | 0.9320 | 0.7422 | 1.955 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.68385</span> | 90.58 | 0.002133 | 0.2693 | 0.1284 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01118 | 0.5515 | 1.933 | 0.03207 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8021 | 0.06900 | 0.7062 | 0.6043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.405 | 0.9320 | 0.7422 | 1.955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 467.87907 | 1.005 | -1.909 | -0.9308 | -0.7628 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9639 | -1.503 | 1.779 | -1.847 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8965 | -0.4841 | -0.8880 | -1.173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6287 | -0.8610 | -0.9975 | -0.3740 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.87907 | 91.48 | -6.109 | -0.9081 | -2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.576 | 0.1745 | 1.931 | 0.03026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8209 | 0.06979 | 0.7229 | 0.6325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.466 | 0.9660 | 0.7566 | 1.812 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.87907</span> | 91.48 | 0.002222 | 0.2874 | 0.1320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01029 | 0.5435 | 1.931 | 0.03026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8209 | 0.06979 | 0.7229 | 0.6325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.466 | 0.9660 | 0.7566 | 1.812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 467.53566 | 1.009 | -1.902 | -0.9117 | -0.7577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9793 | -1.516 | 1.778 | -1.859 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8880 | -0.4790 | -0.8835 | -1.168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8545 | -0.9947 | -0.3959 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.53566 | 91.86 | -6.102 | -0.8912 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1685 | 1.931 | 0.02992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7261 | 0.6369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7591 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.53566</span> | 91.86 | 0.002239 | 0.2909 | 0.1326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7261 | 0.6369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7591 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 467.26444 | 1.016 | -1.902 | -0.9109 | -0.7577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -1.516 | 1.777 | -1.860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8875 | -0.4788 | -0.8828 | -1.169 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6198 | -0.8544 | -0.9951 | -0.3961 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.26444 | 92.48 | -6.102 | -0.8905 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1683 | 1.931 | 0.02990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8246 | 0.06995 | 0.7266 | 0.6360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7588 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.26444</span> | 92.48 | 0.002239 | 0.2910 | 0.1326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02990 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8246 | 0.06995 | 0.7266 | 0.6360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7588 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.458 | 0.09189 | 2.450 | 0.1713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5320 | -1.492 | -1.346 | -2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.374 | 0.8089 | 1.804 | -5.854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.303 | 0.2787 | -1.170 | -0.8602 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 467.25360 | 1.017 | -1.902 | -0.9116 | -0.7577 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9793 | -1.516 | 1.778 | -1.859 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8879 | -0.4790 | -0.8833 | -1.168 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.8545 | -0.9948 | -0.3959 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.2536 | 92.51 | -6.102 | -0.8910 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1685 | 1.931 | 0.02992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7263 | 0.6374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7590 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.2536</span> | 92.51 | 0.002239 | 0.2909 | 0.1326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02992 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7263 | 0.6374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7590 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.196 | 0.08873 | 2.446 | 0.1672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5342 | -1.484 | -1.056 | -1.956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.373 | 0.7965 | 2.077 | -5.722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.292 | 0.2471 | -1.040 | -0.8496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 467.24389 | 1.015 | -1.902 | -0.9128 | -0.7578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9790 | -1.515 | 1.778 | -1.858 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8886 | -0.4794 | -0.8844 | -1.165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6188 | -0.8546 | -0.9942 | -0.3955 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.24389 | 92.37 | -6.102 | -0.8922 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1688 | 1.931 | 0.02995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8242 | 0.06993 | 0.7255 | 0.6400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9721 | 0.7595 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.24389</span> | 92.37 | 0.002239 | 0.2907 | 0.1326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.5421 | 1.931 | 0.02995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8242 | 0.06993 | 0.7255 | 0.6400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9721 | 0.7595 | 1.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.43 | 0.07336 | 2.305 | 0.1893 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5256 | -1.495 | -1.329 | -2.142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.357 | 0.9382 | 1.940 | -3.165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.157 | 0.2760 | -0.9277 | -0.8566 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 467.22397 | 1.017 | -1.902 | -0.9138 | -0.7581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9782 | -1.514 | 1.778 | -1.857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | -0.4797 | -0.8863 | -1.164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6190 | -0.8552 | -0.9945 | -0.3935 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.22397 | 92.56 | -6.102 | -0.8930 | -2.020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.1692 | 1.931 | 0.02998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8241 | 0.06992 | 0.7241 | 0.6409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9715 | 0.7593 | 1.789 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.22397</span> | 92.56 | 0.002238 | 0.2905 | 0.1326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01015 | 0.5422 | 1.931 | 0.02998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8241 | 0.06992 | 0.7241 | 0.6409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9715 | 0.7593 | 1.789 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.612 | 0.07601 | 2.377 | 0.1597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5308 | -1.476 | -1.038 | -1.834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.332 | 0.7679 | 2.039 | -3.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.288 | 0.2037 | -1.093 | -0.8313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 467.20858 | 1.016 | -1.903 | -0.9153 | -0.7584 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9772 | -1.513 | 1.777 | -1.856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8896 | -0.4802 | -0.8882 | -1.164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8560 | -0.9946 | -0.3915 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.20858 | 92.46 | -6.103 | -0.8944 | -2.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.590 | 0.1698 | 1.931 | 0.03001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8238 | 0.06990 | 0.7227 | 0.6411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9707 | 0.7591 | 1.791 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.20858</span> | 92.46 | 0.002236 | 0.2902 | 0.1325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01016 | 0.5423 | 1.931 | 0.03001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8238 | 0.06990 | 0.7227 | 0.6411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9707 | 0.7591 | 1.791 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.651 | 0.07137 | 2.259 | 0.1744 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5171 | -1.486 | -1.304 | -1.934 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.324 | 0.7910 | 1.690 | -3.053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.233 | 0.1999 | -1.046 | -0.8164 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 467.19548 | 1.017 | -1.903 | -0.9170 | -0.7588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9762 | -1.512 | 1.778 | -1.855 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8906 | -0.4808 | -0.8898 | -1.163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.8567 | -0.9946 | -0.3897 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.19548 | 92.56 | -6.103 | -0.8959 | -2.021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.589 | 0.1705 | 1.931 | 0.03005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06989 | 0.7215 | 0.6417 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9701 | 0.7592 | 1.793 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.19548</span> | 92.56 | 0.002235 | 0.2899 | 0.1325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01017 | 0.5425 | 1.931 | 0.03005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06989 | 0.7215 | 0.6417 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9701 | 0.7592 | 1.793 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.695 | 0.07360 | 2.256 | 0.1610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5147 | -1.467 | -1.275 | -1.734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.307 | 0.8740 | 2.039 | -5.568 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.898 | -0.2550 | -1.273 | -0.7762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 467.17845 | 1.016 | -1.904 | -0.9175 | -0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9751 | -1.510 | 1.777 | -1.854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8907 | -0.4813 | -0.8918 | -1.161 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8571 | -0.9949 | -0.3876 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.17845 | 92.50 | -6.104 | -0.8963 | -2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.588 | 0.1711 | 1.930 | 0.03007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06987 | 0.7201 | 0.6433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9697 | 0.7589 | 1.796 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.17845</span> | 92.50 | 0.002234 | 0.2898 | 0.1324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01018 | 0.5427 | 1.930 | 0.03007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06987 | 0.7201 | 0.6433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9697 | 0.7589 | 1.796 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.021 | 0.06308 | 2.194 | 0.1658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5050 | -1.471 | -1.283 | -1.811 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.304 | 0.7659 | 1.629 | -2.860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.234 | 0.1434 | -1.025 | -0.7796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 467.16518 | 1.015 | -1.904 | -0.9192 | -0.7596 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9742 | -1.509 | 1.777 | -1.853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.4819 | -0.8931 | -1.160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6190 | -0.8574 | -0.9946 | -0.3864 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.16518 | 92.39 | -6.104 | -0.8978 | -2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.587 | 0.1719 | 1.931 | 0.03011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8229 | 0.06985 | 0.7191 | 0.6447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9694 | 0.7592 | 1.797 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.16518</span> | 92.39 | 0.002234 | 0.2895 | 0.1324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01019 | 0.5429 | 1.931 | 0.03011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8229 | 0.06985 | 0.7191 | 0.6447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9694 | 0.7592 | 1.797 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.15 | 0.05292 | 2.063 | 0.1800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4962 | -1.473 | -0.9311 | -1.912 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.287 | 0.8965 | 1.659 | -5.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.766 | -0.2649 | -1.228 | -0.7899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 467.14275 | 1.016 | -1.904 | -0.9201 | -0.7599 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9736 | -1.507 | 1.777 | -1.851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8922 | -0.4826 | -0.8948 | -1.157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6182 | -0.8576 | -0.9943 | -0.3850 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.14275 | 92.43 | -6.104 | -0.8986 | -2.022 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.586 | 0.1725 | 1.931 | 0.03014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8227 | 0.06984 | 0.7179 | 0.6470 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 0.9693 | 0.7594 | 1.799 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.14275</span> | 92.43 | 0.002233 | 0.2893 | 0.1324 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01019 | 0.5430 | 1.931 | 0.03014 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8227 | 0.06984 | 0.7179 | 0.6470 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 0.9693 | 0.7594 | 1.799 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.177 | 0.04590 | 2.051 | 0.1758 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4936 | -1.461 | -0.9893 | -1.828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.266 | 0.7615 | 1.545 | -5.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.792 | -0.2512 | -1.220 | -0.7551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 467.10820 | 1.017 | -1.905 | -0.9220 | -0.7605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9724 | -1.505 | 1.777 | -1.849 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8932 | -0.4835 | -0.8976 | -1.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6164 | -0.8576 | -0.9935 | -0.3828 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.1082 | 92.55 | -6.105 | -0.9003 | -2.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.585 | 0.1737 | 1.930 | 0.03020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8223 | 0.06981 | 0.7158 | 0.6522 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 0.9692 | 0.7601 | 1.802 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.1082</span> | 92.55 | 0.002232 | 0.2890 | 0.1323 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01020 | 0.5433 | 1.930 | 0.03020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8223 | 0.06981 | 0.7158 | 0.6522 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 0.9692 | 0.7601 | 1.802 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.449 | 0.03092 | 2.044 | 0.1611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4934 | -1.430 | -1.221 | -1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.229 | 0.8691 | 1.875 | -2.123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.605 | -0.2558 | -1.009 | -0.7122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 467.10106 | 1.014 | -1.905 | -0.9236 | -0.7611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9712 | -1.502 | 1.777 | -1.847 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.4849 | -0.9012 | -1.147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6148 | -0.8578 | -0.9928 | -0.3803 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.10106 | 92.28 | -6.105 | -0.9017 | -2.023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.584 | 0.1749 | 1.930 | 0.03026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8220 | 0.06977 | 0.7132 | 0.6562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 0.9690 | 0.7607 | 1.805 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.10106</span> | 92.28 | 0.002232 | 0.2887 | 0.1322 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01022 | 0.5436 | 1.930 | 0.03026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8220 | 0.06977 | 0.7132 | 0.6562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 0.9690 | 0.7607 | 1.805 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -24.17 | 0.001665 | 1.814 | 0.1960 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4738 | -1.444 | -0.8955 | -1.908 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.221 | 0.7910 | 1.755 | -3.560 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.244 | -0.2675 | -0.8607 | -0.7175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 467.04630 | 1.016 | -1.905 | -0.9246 | -0.7619 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9696 | -1.499 | 1.777 | -1.845 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8944 | -0.4866 | -0.9055 | -1.143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6133 | -0.8582 | -0.9923 | -0.3775 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.0463 | 92.45 | -6.105 | -0.9026 | -2.024 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.582 | 0.1762 | 1.930 | 0.03032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8218 | 0.06972 | 0.7101 | 0.6601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 0.9686 | 0.7611 | 1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.0463</span> | 92.45 | 0.002231 | 0.2885 | 0.1321 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01023 | 0.5439 | 1.930 | 0.03032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8218 | 0.06972 | 0.7101 | 0.6601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 0.9686 | 0.7611 | 1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.647 | -0.007887 | 1.876 | 0.1719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4730 | -1.410 | -0.8701 | -1.589 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.184 | 0.7244 | 1.544 | -4.110 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.544 | -0.3120 | -0.9430 | -0.6527 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 467.02543 | 1.017 | -1.906 | -0.9263 | -0.7625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9684 | -1.497 | 1.777 | -1.843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8954 | -0.4879 | -0.9089 | -1.137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6116 | -0.8583 | -0.9915 | -0.3753 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 467.02543 | 92.58 | -6.106 | -0.9041 | -2.025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.581 | 0.1775 | 1.930 | 0.03038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8214 | 0.06968 | 0.7076 | 0.6649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 0.9686 | 0.7618 | 1.811 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.02543</span> | 92.58 | 0.002230 | 0.2882 | 0.1320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01025 | 0.5443 | 1.930 | 0.03038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8214 | 0.06968 | 0.7076 | 0.6649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 0.9686 | 0.7618 | 1.811 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.94 | -0.02385 | 1.879 | 0.1542 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4735 | -1.378 | -0.8918 | -1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.131 | 0.6590 | 1.631 | -3.618 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.430 | -0.2321 | -0.8462 | -0.6495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 466.99646 | 1.016 | -1.906 | -0.9273 | -0.7632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9670 | -1.494 | 1.776 | -1.841 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8958 | -0.4892 | -0.9132 | -1.133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6101 | -0.8587 | -0.9911 | -0.3725 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.99646 | 92.42 | -6.106 | -0.9050 | -2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.579 | 0.1788 | 1.930 | 0.03043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8212 | 0.06964 | 0.7044 | 0.6690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 0.9682 | 0.7622 | 1.814 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.99646</span> | 92.42 | 0.002230 | 0.2880 | 0.1319 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01026 | 0.5446 | 1.930 | 0.03043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8212 | 0.06964 | 0.7044 | 0.6690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 0.9682 | 0.7622 | 1.814 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.590 | -0.05004 | 1.738 | 0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4573 | -1.378 | -0.8791 | -1.534 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.117 | 0.8064 | 1.528 | -3.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8220 | 0.1296 | -0.3838 | -0.6246 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 466.97639 | 1.017 | -1.906 | -0.9282 | -0.7640 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9655 | -1.490 | 1.776 | -1.839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8964 | -0.4910 | -0.9175 | -1.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6092 | -0.8593 | -0.9910 | -0.3693 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.97639 | 92.52 | -6.106 | -0.9059 | -2.026 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.578 | 0.1803 | 1.930 | 0.03049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8210 | 0.06959 | 0.7013 | 0.6726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9676 | 0.7623 | 1.818 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.97639</span> | 92.52 | 0.002230 | 0.2878 | 0.1318 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01028 | 0.5450 | 1.930 | 0.03049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8210 | 0.06959 | 0.7013 | 0.6726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9676 | 0.7623 | 1.818 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.027 | -0.06281 | 1.755 | 0.1604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4507 | -1.349 | -0.8053 | -1.299 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.095 | 0.6623 | 1.032 | -2.794 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8171 | 0.07286 | -0.3538 | -0.5889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 466.96001 | 1.015 | -1.906 | -0.9299 | -0.7649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9637 | -1.486 | 1.775 | -1.837 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8976 | -0.4931 | -0.9192 | -1.125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6091 | -0.8600 | -0.9916 | -0.3657 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.96001 | 92.40 | -6.106 | -0.9074 | -2.027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.576 | 0.1824 | 1.930 | 0.03055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8205 | 0.06953 | 0.7000 | 0.6758 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9669 | 0.7618 | 1.823 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.96001</span> | 92.40 | 0.002230 | 0.2875 | 0.1317 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01029 | 0.5455 | 1.930 | 0.03055 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8205 | 0.06953 | 0.7000 | 0.6758 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9669 | 0.7618 | 1.823 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.315 | -0.08361 | 1.595 | 0.1755 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4289 | -1.331 | -0.8104 | -1.428 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.055 | 0.7710 | 1.242 | -2.826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.346 | -0.3282 | -0.6399 | -0.5709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 466.94053 | 1.016 | -1.905 | -0.9315 | -0.7662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9617 | -1.480 | 1.774 | -1.835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8987 | -0.4954 | -0.9193 | -1.121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6079 | -0.8601 | -0.9919 | -0.3632 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.94053 | 92.48 | -6.105 | -0.9088 | -2.029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.574 | 0.1849 | 1.929 | 0.03061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06946 | 0.6999 | 0.6792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 0.9668 | 0.7615 | 1.826 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.94053</span> | 92.48 | 0.002231 | 0.2873 | 0.1315 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01031 | 0.5461 | 1.929 | 0.03061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06946 | 0.6999 | 0.6792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 0.9668 | 0.7615 | 1.826 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.448 | -0.09452 | 1.578 | 0.1631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4178 | -1.275 | -0.7880 | -1.291 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.013 | 0.7275 | 1.336 | -0.1176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.297 | -0.2757 | -0.6338 | -0.5586 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 466.92529 | 1.015 | -1.905 | -0.9321 | -0.7676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9593 | -1.476 | 1.775 | -1.833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8992 | -0.4984 | -0.9232 | -1.122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6063 | -0.8604 | -0.9916 | -0.3612 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.92529 | 92.34 | -6.105 | -0.9093 | -2.030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.572 | 0.1871 | 1.930 | 0.03066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8198 | 0.06938 | 0.6971 | 0.6791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 0.9666 | 0.7618 | 1.828 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.92529</span> | 92.34 | 0.002233 | 0.2871 | 0.1313 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01034 | 0.5466 | 1.930 | 0.03066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8198 | 0.06938 | 0.6971 | 0.6791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 0.9666 | 0.7618 | 1.828 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.72 | -0.09950 | 1.479 | 0.1754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4012 | -1.242 | -0.7866 | -1.413 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9668 | 0.6187 | 0.9349 | -2.630 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.260 | -0.3489 | -0.4063 | -0.5476 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 466.89942 | 1.016 | -1.904 | -0.9326 | -0.7693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -1.470 | 1.775 | -1.832 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8995 | -0.5006 | -0.9260 | -1.122 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6055 | -0.8609 | -0.9921 | -0.3587 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.89942 | 92.48 | -6.104 | -0.9097 | -2.032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.569 | 0.1897 | 1.929 | 0.03069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8197 | 0.06931 | 0.6950 | 0.6788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9661 | 0.7614 | 1.831 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.89942</span> | 92.48 | 0.002235 | 0.2871 | 0.1311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01037 | 0.5473 | 1.929 | 0.03069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8197 | 0.06931 | 0.6950 | 0.6788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9661 | 0.7614 | 1.831 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.439 | -0.09008 | 1.544 | 0.1555 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3845 | -1.174 | -0.7709 | -1.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9305 | 0.6799 | 1.153 | -2.871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.766 | -0.2963 | -0.5389 | -0.5305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 466.87885 | 1.016 | -1.902 | -0.9335 | -0.7713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9544 | -1.465 | 1.775 | -1.831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8988 | -0.5028 | -0.9291 | -1.120 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6025 | -0.8609 | -0.9918 | -0.3573 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.87885 | 92.42 | -6.102 | -0.9106 | -2.034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.567 | 0.1922 | 1.930 | 0.03072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06925 | 0.6928 | 0.6803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 0.9661 | 0.7616 | 1.833 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.87885</span> | 92.42 | 0.002239 | 0.2869 | 0.1309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01039 | 0.5479 | 1.930 | 0.03072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06925 | 0.6928 | 0.6803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 0.9661 | 0.7616 | 1.833 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.274 | -0.09794 | 1.477 | 0.1445 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3711 | -1.126 | -0.7697 | -1.253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9213 | 0.5797 | 0.6929 | -2.254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4364 | 0.05549 | -0.07007 | -0.5105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 466.87374 | 1.017 | -1.901 | -0.9363 | -0.7725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9523 | -1.459 | 1.775 | -1.829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.5050 | -0.9284 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6029 | -0.8616 | -0.9930 | -0.3542 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.87374 | 92.57 | -6.101 | -0.9131 | -2.035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.565 | 0.1945 | 1.929 | 0.03078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8193 | 0.06919 | 0.6933 | 0.6817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9655 | 0.7605 | 1.836 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.87374</span> | 92.57 | 0.002241 | 0.2864 | 0.1307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01041 | 0.5485 | 1.929 | 0.03078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8193 | 0.06919 | 0.6933 | 0.6817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9655 | 0.7605 | 1.836 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.60 | -0.09484 | 1.445 | 0.1251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3584 | -1.070 | -0.7354 | -1.048 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8551 | 0.6144 | 0.8824 | -0.009520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4410 | 0.04024 | -0.2274 | -0.5153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 466.85547 | 1.016 | -1.900 | -0.9388 | -0.7737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9500 | -1.454 | 1.774 | -1.828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.5070 | -0.9271 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6040 | -0.8622 | -0.9946 | -0.3509 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.85547 | 92.42 | -6.100 | -0.9152 | -2.036 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.562 | 0.1970 | 1.929 | 0.03083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8186 | 0.06913 | 0.6942 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 0.9648 | 0.7592 | 1.841 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.85547</span> | 92.42 | 0.002243 | 0.2859 | 0.1305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01044 | 0.5491 | 1.929 | 0.03083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8186 | 0.06913 | 0.6942 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 0.9648 | 0.7592 | 1.841 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.539 | -0.09755 | 1.262 | 0.1433 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3291 | -1.038 | -0.7482 | -1.225 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8087 | 0.5023 | 0.8171 | -0.005344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4685 | 0.01356 | -0.1499 | -0.5112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 466.84409 | 1.016 | -1.899 | -0.9408 | -0.7751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9477 | -1.449 | 1.774 | -1.826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | -0.5088 | -0.9269 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6048 | -0.8630 | -0.9960 | -0.3473 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.84409 | 92.47 | -6.099 | -0.9171 | -2.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.560 | 0.1996 | 1.929 | 0.03088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8179 | 0.06907 | 0.6944 | 0.6816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9641 | 0.7580 | 1.845 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.84409</span> | 92.47 | 0.002245 | 0.2856 | 0.1304 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01046 | 0.5497 | 1.929 | 0.03088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8179 | 0.06907 | 0.6944 | 0.6816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9641 | 0.7580 | 1.845 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.205 | -0.09489 | 1.201 | 0.1289 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3142 | -0.9889 | -0.7667 | -1.156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7401 | 0.5570 | 1.301 | -1.479 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.860 | -0.4540 | -0.5722 | -0.5005 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 466.83069 | 1.016 | -1.897 | -0.9405 | -0.7762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9462 | -1.443 | 1.775 | -1.825 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9047 | -0.5101 | -0.9307 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6046 | -0.8636 | -0.9969 | -0.3435 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.83069 | 92.41 | -6.097 | -0.9168 | -2.039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.559 | 0.2019 | 1.929 | 0.03091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8175 | 0.06904 | 0.6917 | 0.6819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9635 | 0.7572 | 1.850 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.83069</span> | 92.41 | 0.002250 | 0.2856 | 0.1302 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01048 | 0.5503 | 1.929 | 0.03091 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8175 | 0.06904 | 0.6917 | 0.6819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9635 | 0.7572 | 1.850 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 466.81923 | 1.016 | -1.894 | -0.9398 | -0.7773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9447 | -1.438 | 1.775 | -1.824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9056 | -0.5113 | -0.9343 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | -0.8643 | -0.9979 | -0.3395 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.81923 | 92.43 | -6.094 | -0.9162 | -2.040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.557 | 0.2043 | 1.930 | 0.03094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8171 | 0.06900 | 0.6890 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9628 | 0.7563 | 1.854 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.81923</span> | 92.43 | 0.002255 | 0.2857 | 0.1301 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01049 | 0.5509 | 1.930 | 0.03094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8171 | 0.06900 | 0.6890 | 0.6818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9628 | 0.7563 | 1.854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 466.78977 | 1.016 | -1.887 | -0.9376 | -0.7810 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9400 | -1.422 | 1.776 | -1.820 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9086 | -0.5153 | -0.9461 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6057 | -0.8666 | -1.001 | -0.3266 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.78977 | 92.47 | -6.087 | -0.9142 | -2.043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.552 | 0.2120 | 1.930 | 0.03105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8159 | 0.06889 | 0.6804 | 0.6815 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9606 | 0.7533 | 1.870 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.78977</span> | 92.47 | 0.002272 | 0.2861 | 0.1296 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01054 | 0.5528 | 1.930 | 0.03105 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8159 | 0.06889 | 0.6804 | 0.6815 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9606 | 0.7533 | 1.870 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 466.76586 | 1.017 | -1.875 | -0.9340 | -0.7871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9321 | -1.394 | 1.779 | -1.814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9134 | -0.5218 | -0.9656 | -1.119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6071 | -0.8705 | -1.007 | -0.3052 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.76586 | 92.53 | -6.075 | -0.9110 | -2.049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.545 | 0.2247 | 1.931 | 0.03121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8139 | 0.06870 | 0.6661 | 0.6811 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 0.9569 | 0.7485 | 1.896 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.76586</span> | 92.53 | 0.002300 | 0.2868 | 0.1288 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01062 | 0.5559 | 1.931 | 0.03121 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8139 | 0.06870 | 0.6661 | 0.6811 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 0.9569 | 0.7485 | 1.896 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.71 | -0.05605 | 1.440 | 0.09508 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1459 | -0.5070 | -0.9907 | -0.8007 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4069 | 0.2923 | 0.01818 | -1.553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.109 | -0.3306 | -0.3991 | -0.2309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 466.72646 | 1.014 | -1.848 | -0.9815 | -0.8092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9160 | -1.342 | 1.783 | -1.808 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | -0.5322 | -0.9570 | -1.117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6032 | -0.8748 | -1.022 | -0.2748 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.72646 | 92.30 | -6.048 | -0.9533 | -2.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2483 | 1.933 | 0.03140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8182 | 0.06840 | 0.6724 | 0.6828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9528 | 0.7357 | 1.933 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.72646</span> | 92.30 | 0.002362 | 0.2782 | 0.1260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01080 | 0.5618 | 1.933 | 0.03140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8182 | 0.06840 | 0.6724 | 0.6828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9528 | 0.7357 | 1.933 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.11 | -0.01237 | -0.5306 | 0.001870 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01074 | -0.001553 | -0.5011 | -1.124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5240 | 0.3999 | 0.1337 | 0.6209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3667 | -0.5464 | -0.9326 | -0.1861 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 466.72714 | 1.014 | -1.830 | -0.9704 | -0.8250 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9153 | -1.342 | 1.791 | -1.785 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9449 | -0.5943 | -0.9266 | -1.116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5962 | -0.8737 | -1.020 | -0.2698 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.72714 | 92.32 | -6.030 | -0.9434 | -2.087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2486 | 1.936 | 0.03205 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8009 | 0.06660 | 0.6946 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.504 | 0.9539 | 0.7372 | 1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.72714</span> | 92.32 | 0.002405 | 0.2802 | 0.1240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01081 | 0.5618 | 1.936 | 0.03205 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8009 | 0.06660 | 0.6946 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.504 | 0.9539 | 0.7372 | 1.939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 466.69721 | 1.015 | -1.839 | -0.9760 | -0.8170 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9156 | -1.342 | 1.787 | -1.797 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9238 | -0.5630 | -0.9420 | -1.117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5997 | -0.8742 | -1.021 | -0.2723 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.69721 | 92.41 | -6.039 | -0.9484 | -2.079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2485 | 1.935 | 0.03173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8096 | 0.06750 | 0.6834 | 0.6836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9534 | 0.7365 | 1.936 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69721</span> | 92.41 | 0.002383 | 0.2792 | 0.1250 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01080 | 0.5618 | 1.935 | 0.03173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8096 | 0.06750 | 0.6834 | 0.6836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9534 | 0.7365 | 1.936 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.5723 | 0.006769 | -0.2879 | -0.06332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01114 | -0.03155 | -0.3915 | -0.7923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3201 | -0.2330 | 0.8086 | -1.424 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3663 | -0.4815 | -0.7933 | -0.2384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 466.73286 | 1.017 | -1.834 | -0.9731 | -0.8131 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9227 | -1.351 | 1.796 | -1.779 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9201 | -0.5595 | -0.9572 | -1.109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6142 | -0.8686 | -1.016 | -0.2440 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.73286 | 92.54 | -6.034 | -0.9458 | -2.075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.535 | 0.2444 | 1.938 | 0.03223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8111 | 0.06760 | 0.6723 | 0.6901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 0.9587 | 0.7409 | 1.970 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.73286</span> | 92.54 | 0.002396 | 0.2797 | 0.1255 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01072 | 0.5608 | 1.938 | 0.03223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8111 | 0.06760 | 0.6723 | 0.6901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 0.9587 | 0.7409 | 1.970 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 466.69733 | 1.015 | -1.838 | -0.9750 | -0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9176 | -1.345 | 1.790 | -1.791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9226 | -0.5619 | -0.9467 | -1.114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6033 | -0.8723 | -1.019 | -0.2644 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.69733 | 92.40 | -6.038 | -0.9475 | -2.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.530 | 0.2474 | 1.936 | 0.03188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8101 | 0.06754 | 0.6799 | 0.6863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9552 | 0.7382 | 1.945 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69733</span> | 92.40 | 0.002386 | 0.2794 | 0.1251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5615 | 1.936 | 0.03188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8101 | 0.06754 | 0.6799 | 0.6863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9552 | 0.7382 | 1.945 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 466.69584 | 1.015 | -1.839 | -0.9754 | -0.8165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9164 | -1.343 | 1.788 | -1.794 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9231 | -0.5623 | -0.9445 | -1.114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6009 | -0.8731 | -1.020 | -0.2689 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.69584 | 92.37 | -6.039 | -0.9478 | -2.079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2480 | 1.935 | 0.03180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8099 | 0.06752 | 0.6815 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9544 | 0.7377 | 1.940 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69584</span> | 92.37 | 0.002384 | 0.2793 | 0.1251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5617 | 1.935 | 0.03180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8099 | 0.06752 | 0.6815 | 0.6857 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9544 | 0.7377 | 1.940 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.069 | -0.001275 | -0.2861 | -0.04975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01387 | -0.05203 | -0.3437 | -0.7173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2694 | -0.1778 | 0.5026 | 0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9213 | -0.7376 | -0.9765 | -0.1682 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 466.68962 | 1.016 | -1.839 | -0.9764 | -0.8159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9167 | -1.342 | 1.790 | -1.793 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9191 | -0.5597 | -0.9461 | -1.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8712 | -1.018 | -0.2680 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.68962 | 92.46 | -6.039 | -0.9488 | -2.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2485 | 1.936 | 0.03184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8115 | 0.06760 | 0.6803 | 0.6854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9562 | 0.7392 | 1.941 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.68962</span> | 92.46 | 0.002385 | 0.2791 | 0.1251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5618 | 1.936 | 0.03184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8115 | 0.06760 | 0.6803 | 0.6854 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9562 | 0.7392 | 1.941 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.342 | 0.001592 | -0.2787 | -0.05882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.004933 | -0.02534 | -0.4440 | -0.5467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1484 | -0.03146 | 0.4648 | -1.264 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3607 | -0.2274 | -0.5157 | -0.1312 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 139</span>| 466.68314 | 1.015 | -1.839 | -0.9751 | -0.8151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9166 | -1.339 | 1.792 | -1.792 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9160 | -0.5585 | -0.9470 | -1.115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5998 | -0.8691 | -1.016 | -0.2676 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.68314 | 92.36 | -6.039 | -0.9476 | -2.077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2501 | 1.937 | 0.03187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8128 | 0.06763 | 0.6797 | 0.6853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9582 | 0.7404 | 1.942 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.68314</span> | 92.36 | 0.002385 | 0.2794 | 0.1252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5622 | 1.937 | 0.03187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8128 | 0.06763 | 0.6797 | 0.6853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9582 | 0.7404 | 1.942 |</span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.258 |-0.0003497 | -0.2788 | -0.03383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01408 | 0.02647 | -0.2857 | -0.5956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05089 | 0.05050 | 0.4395 | 0.8187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2669 | -0.06868 | -0.3694 | -0.1159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 140</span>| 466.67997 | 1.015 | -1.839 | -0.9739 | -0.8142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9180 | -1.339 | 1.794 | -1.790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | -0.5623 | -0.9494 | -1.116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8690 | -1.016 | -0.2664 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.67997 | 92.38 | -6.039 | -0.9465 | -2.077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.531 | 0.2499 | 1.938 | 0.03191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.67997</span> | 92.38 | 0.002385 | 0.2796 | 0.1254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5622 | 1.938 | 0.03191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> | M| Mixed Diff. | -1.882 |-7.391e+04 | -0.2259 | -0.03295 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.005718 | 0.01130 | -0.3842 | -0.4930 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04972 | -0.05953 | 0.5251 | -1.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3564 | -0.08212 | -0.3242 | -0.1008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 141</span>| 466.67997 | 1.015 | -1.839 | -0.9739 | -0.8142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9180 | -1.339 | 1.794 | -1.790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | -0.5623 | -0.9494 | -1.116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8690 | -1.016 | -0.2664 |</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 466.67997 | 92.38 | -6.039 | -0.9465 | -2.077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.531 | 0.2499 | 1.938 | 0.03191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.67997</span> | 92.38 | 0.002385 | 0.2796 | 0.1254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5622 | 1.938 | 0.03191 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance, can check sandwich or S matrix with $covRS and $covS</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="va">f_nlmixr_sfo_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_saem_obs</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_obs</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_saem_obs</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_obs</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_tc</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_tc</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_saem_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_saem_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> +<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_obs_tc</span><span class="op">$</span><span class="va">nm</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_sfo_focei_const$nm 9 1082.4605</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_const$nm 11 814.4261</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_const$nm 13 870.2659</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_saem_obs$nm 12 788.8373</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_obs$nm 12 794.5194</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem_obs$nm 14 815.0797</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_obs$nm 14 834.8474</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_tc$nm 12 812.3296</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_tc$nm 14 819.4103</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_saem_obs_tc$nm 14 814.4248</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_obs_tc$nm 14 787.4355</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem_obs_tc$nm 16 828.5143</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_obs_tc$nm 16 811.1191</span> +<span class="r-in"><span class="co"># Currently, FOMC-SFO with two-component error by variable fitted by focei gives the</span></span> +<span class="r-in"><span class="co"># lowest AIC</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">)</span></span> +<span class="r-plt img"><img src="nlmixr.mmkin-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> nlmixr version used for fitting: 2.0.6 </span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 18:01:07 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 18:02:45 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + f_parent_to_A1 * (alpha/beta) * 1/((time/beta) + 1) *</span> +<span class="r-out co"><span class="r-pr">#></span> parent - k_A1 * A1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Degradation model predictions using RxODE</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted in 17.315 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance unique to each observed variable </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_A1 f_parent_qlogis log_alpha log_beta </span> +<span class="r-out co"><span class="r-pr">#></span> 93.1168 -5.3034 -0.9442 -0.1065 2.2909 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for error model parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_parent rsd_high_parent sigma_low_A1 rsd_high_A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 1.15958 0.03005 1.15958 0.03005 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Likelihood calculated by focei </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 787.4 831.3 -379.7</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 93.6717 91.2552 96.0882</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_A1 -6.3199 -8.4468 -4.1930</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -1.0089 -1.3823 -0.6356</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha -0.1616 -0.6624 0.3392</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 2.2088 1.6800 2.7376</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> +<span class="r-out co"><span class="r-pr">#></span> parnt_0 lg_k_A1 f_prnt_ log_lph</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_A1 0.3717 </span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.7856 -0.4088 </span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.3361 0.9419 -0.3063 </span> +<span class="r-out co"><span class="r-pr">#></span> log_beta -0.3985 -0.7595 0.2484 -0.5549</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects (omega):</span> +<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 eta.log_k_A1 eta.f_parent_qlogis eta.log_alpha</span> +<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 4.391 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 0.000 6.402 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis 0.000 0.000 0.1584 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_alpha 0.000 0.000 0.0000 0.3381</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_beta 0.000 0.000 0.0000 0.0000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_beta</span> +<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_alpha 0.000</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_beta 0.358</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_low_parent rsd_high_parent sigma_low_A1 rsd_high_A1 </span> +<span class="r-out co"><span class="r-pr">#></span> 2.35616 0.00153 0.63564 0.08639 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 93.6717 9.126e+01 96.0882</span> +<span class="r-out co"><span class="r-pr">#></span> k_A1 0.0018 2.146e-04 0.0151</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_A1 0.2672 2.006e-01 0.3462</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 0.8508 5.156e-01 1.4038</span> +<span class="r-out co"><span class="r-pr">#></span> beta 9.1049 5.366e+00 15.4499</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> +<span class="r-out co"><span class="r-pr">#></span> ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_A1 0.2672</span> +<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.7328</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> +<span class="r-out co"><span class="r-pr">#></span> parent 11.46 127.3 38.31</span> +<span class="r-out co"><span class="r-pr">#></span> A1 385.05 1279.1 NA</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Two parallel metabolites</span></span> +<span class="r-in"><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> +<span class="r-in"> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span> +<span class="r-in"> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span> +<span class="r-in"> <span class="va">ds_i</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> +<span class="r-in"><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> +<span class="r-in"><span class="va">sfo_sfo2</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> DMTA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M23 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M27 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-in"><span class="va">f_dmta_sfo_sfo2</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO2"</span> <span class="op">=</span> <span class="va">sfo_sfo2</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">dmta_ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">nlmixr_model</span><span class="op">(</span><span class="va">f_dmta_sfo_sfo2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> function () </span> +<span class="r-out co"><span class="r-pr">#></span> {</span> +<span class="r-out co"><span class="r-pr">#></span> ini({</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0 = 97</span> +<span class="r-out co"><span class="r-pr">#></span> eta.DMTA_0 ~ 2</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_DMTA = -2.9</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_DMTA ~ 0.66</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M23 = -3.8</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M23 ~ 0.52</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M27 = -5.7</span> +<span class="r-out co"><span class="r-pr">#></span> eta.log_k_M27 ~ 2</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1_qlogis = -2.1</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_1_qlogis ~ 0.3</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2_qlogis = -2</span> +<span class="r-out co"><span class="r-pr">#></span> eta.f_DMTA_tffm0_2_qlogis ~ 0.3</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_DMTA = 2.1</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_M23 = 0.71</span> +<span class="r-out co"><span class="r-pr">#></span> sigma_M27 = 0.56</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> model({</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA_0_model = DMTA_0 + eta.DMTA_0</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA(0) = DMTA_0_model</span> +<span class="r-out co"><span class="r-pr">#></span> k_DMTA = exp(log_k_DMTA + eta.log_k_DMTA)</span> +<span class="r-out co"><span class="r-pr">#></span> k_M23 = exp(log_k_M23 + eta.log_k_M23)</span> +<span class="r-out co"><span class="r-pr">#></span> k_M27 = exp(log_k_M27 + eta.log_k_M27)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_1 = expit(f_DMTA_tffm0_1_qlogis + eta.f_DMTA_tffm0_1_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_tffm0_2 = expit(f_DMTA_tffm0_2_qlogis + eta.f_DMTA_tffm0_2_qlogis)</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M23 = f_DMTA_tffm0_1</span> +<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M27 = f_DMTA_tffm0_2 * (1 - f_DMTA_tffm0_1)</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(DMTA) = -k_DMTA * DMTA</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(M23) = +f_DMTA_to_M23 * k_DMTA * DMTA - k_M23 * </span> +<span class="r-out co"><span class="r-pr">#></span> M23</span> +<span class="r-out co"><span class="r-pr">#></span> d/dt(M27) = +f_DMTA_to_M27 * k_DMTA * DMTA - k_M27 * </span> +<span class="r-out co"><span class="r-pr">#></span> M27</span> +<span class="r-out co"><span class="r-pr">#></span> DMTA ~ add(sigma_DMTA)</span> +<span class="r-out co"><span class="r-pr">#></span> M23 ~ add(sigma_M23)</span> +<span class="r-out co"><span class="r-pr">#></span> M27 ~ add(sigma_M27)</span> +<span class="r-out co"><span class="r-pr">#></span> })</span> +<span class="r-out co"><span class="r-pr">#></span> }</span> +<span class="r-out co"><span class="r-pr">#></span> <environment: 0x555564ac3818></span> +<span class="r-in"><span class="va">nlmixr_focei_dmta_sfo_sfo2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_dmta_sfo_sfo2</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | DMTA_0 |log_k_DMTA | log_k_M23 | log_k_M27 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................|f_DMTA_tffm0_1_qlogis |f_DMTA_tffm0_2_qlogis |sigma_DMTA | sigma_M23 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| sigma_M27 | o1 | o2 | o3 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o4 | o5 | o6 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 833.04051 | 1.000 | -0.9455 | -0.9630 | -1.000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9299 | -0.9279 | -0.8481 | -0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8781 | -0.8726 | -0.8674 | -0.8661 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8726 | -0.8627 | -0.8627 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 833.04051 | 97.00 | -2.900 | -3.800 | -5.700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.100 | -2.000 | 2.100 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5600 | 0.8409 | 1.109 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8409 | 1.351 | 1.351 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 833.04051</span> | 97.00 | 0.05502 | 0.02237 | 0.003346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1091 | 0.1192 | 2.100 | 0.7100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5600 | 0.8409 | 1.109 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8409 | 1.351 | 1.351 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 6.064 | -0.2569 | 9.159 | -2.987 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.463 | 1.428 | -91.01 | -64.30 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -105.9 | 2.473 | -10.56 | 26.93 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.864 | -10.73 | -1.863 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 790.03872 | 0.9615 | -0.9438 | -1.021 | -0.9810 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8952 | -0.9370 | -0.2698 | -0.4666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2051 | -0.8883 | -0.8003 | -1.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8544 | -0.7945 | -0.8508 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 790.03872 | 93.26 | -2.898 | -3.858 | -5.681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.027 | -2.018 | 2.707 | 0.8550 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7484 | 0.8277 | 1.184 | 0.9761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8562 | 1.443 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 790.03872</span> | 93.26 | 0.05511 | 0.02111 | 0.003410 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1164 | 0.1173 | 2.707 | 0.8550 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7484 | 0.8277 | 1.184 | 0.9761 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8562 | 1.443 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1203. | 0.1766 | 3.828 | -3.699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.277 | -3.309 | -7.028 | -3.626 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.785 | 54.50 | -5.905 | 3.230 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.377 | -8.165 | -1.842 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 1615.1823 | 1.259 | -0.9424 | -1.076 | -0.9624 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8623 | -0.9445 | 0.2695 | -0.08596 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4207 | -0.9180 | -0.7364 | -1.197 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8366 | -0.7289 | -0.8393 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 1615.1823 | 122.1 | -2.897 | -3.913 | -5.662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.958 | -2.033 | 3.274 | 0.9902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9237 | 0.8027 | 1.255 | 0.7875 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8712 | 1.532 | 1.383 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1615.1823</span> | 122.1 | 0.05519 | 0.01997 | 0.003474 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1237 | 0.1158 | 3.274 | 0.9902 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9237 | 0.8027 | 1.255 | 0.7875 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8712 | 1.532 | 1.383 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 959.79005 | 1.112 | -0.9439 | -1.022 | -0.9806 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8949 | -0.9366 | -0.2689 | -0.4661 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2049 | -0.8952 | -0.7996 | -1.038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8540 | -0.7935 | -0.8506 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 959.79005 | 107.9 | -2.898 | -3.859 | -5.681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.027 | -2.017 | 2.708 | 0.8552 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 0.8219 | 1.185 | 0.9756 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8566 | 1.445 | 1.368 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 959.79005</span> | 107.9 | 0.05511 | 0.02110 | 0.003412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1164 | 0.1174 | 2.708 | 0.8552 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 0.8219 | 1.185 | 0.9756 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8566 | 1.445 | 1.368 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 766.97120 | 1.000 | -0.9438 | -1.021 | -0.9809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8951 | -0.9369 | -0.2695 | -0.4665 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2050 | -0.8901 | -0.8001 | -1.037 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8543 | -0.7943 | -0.8508 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 766.9712 | 97.04 | -2.898 | -3.858 | -5.681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.027 | -2.018 | 2.707 | 0.8551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 0.8262 | 1.184 | 0.9760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8563 | 1.444 | 1.367 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 766.9712</span> | 97.04 | 0.05511 | 0.02110 | 0.003410 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1164 | 0.1173 | 2.707 | 0.8551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 0.8262 | 1.184 | 0.9760 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8563 | 1.444 | 1.367 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 17.19 | -0.3226 | 4.073 | -3.551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.344 | -0.4208 | 1.861 | -4.402 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.892 | -0.6542 | -5.926 | 4.557 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.217 | -8.034 | -1.874 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 766.81060 | 0.9993 | -0.9437 | -1.024 | -0.9793 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8941 | -0.9371 | -0.2482 | -0.4501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1789 | -0.8907 | -0.7962 | -1.045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8529 | -0.7898 | -0.8499 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 766.8106 | 96.93 | -2.898 | -3.861 | -5.679 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.025 | -2.018 | 2.730 | 0.8609 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7558 | 0.8257 | 1.188 | 0.9671 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8575 | 1.450 | 1.368 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 766.8106</span> | 96.93 | 0.05512 | 0.02104 | 0.003416 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1166 | 0.1173 | 2.730 | 0.8609 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7558 | 0.8257 | 1.188 | 0.9671 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8575 | 1.450 | 1.368 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.39 | -0.3115 | 3.911 | -3.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.518 | -0.5604 | 3.636 | -2.887 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.137 | -0.8386 | -5.861 | 3.544 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.178 | -7.806 | -1.844 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 766.54512 | 1.003 | -0.9428 | -1.036 | -0.9690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8990 | -0.9355 | -0.2617 | -0.4439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1747 | -0.8835 | -0.7794 | -1.053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8438 | -0.7677 | -0.8446 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 766.54512 | 97.33 | -2.897 | -3.873 | -5.669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.035 | -2.015 | 2.716 | 0.8631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7570 | 0.8318 | 1.207 | 0.9569 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8651 | 1.479 | 1.376 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 766.54512</span> | 97.33 | 0.05517 | 0.02081 | 0.003451 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1156 | 0.1176 | 2.716 | 0.8631 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7570 | 0.8318 | 1.207 | 0.9569 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8651 | 1.479 | 1.376 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 111.5 | -0.3718 | 3.702 | -3.687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8687 | -0.06529 | 3.022 | -2.224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.821 | 0.2102 | -4.533 | 2.766 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.768 | -6.628 | -1.505 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 766.09473 | 0.9987 | -0.9419 | -1.044 | -0.9594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9033 | -0.9340 | -0.2855 | -0.4478 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1861 | -0.8834 | -0.7664 | -1.057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8361 | -0.7496 | -0.8403 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 766.09473 | 96.88 | -2.896 | -3.881 | -5.659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.044 | -2.012 | 2.691 | 0.8617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7538 | 0.8318 | 1.221 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8716 | 1.504 | 1.381 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 766.09473</span> | 96.88 | 0.05522 | 0.02062 | 0.003485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1179 | 2.691 | 0.8617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7538 | 0.8318 | 1.221 | 0.9529 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8716 | 1.504 | 1.381 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -37.62 | -0.3039 | 3.548 | -3.796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7130 | -0.2251 | 0.3449 | -2.743 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.783 | -0.4584 | -3.845 | 2.208 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.677 | -5.610 | -1.259 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 765.84632 | 1.001 | -0.9407 | -1.057 | -0.9442 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9332 | -0.3051 | -0.4515 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1945 | -0.8828 | -0.7538 | -1.058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8263 | -0.7302 | -0.8359 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 765.84632 | 97.08 | -2.895 | -3.894 | -5.644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -2.011 | 2.670 | 0.8604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 0.8324 | 1.235 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8799 | 1.530 | 1.387 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 765.84632</span> | 97.08 | 0.05529 | 0.02037 | 0.003538 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1181 | 2.670 | 0.8604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 0.8324 | 1.235 | 0.9520 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8799 | 1.530 | 1.387 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 27.16 | -0.3150 | 3.428 | -3.883 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2016 | -0.01587 | -0.9475 | -2.944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.512 | -0.2026 | -2.920 | 2.169 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.296 | -4.549 | -0.9950 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 765.58952 | 0.9994 | -0.9389 | -1.074 | -0.9188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8956 | -0.9340 | -0.2957 | -0.4491 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1815 | -0.8759 | -0.7498 | -1.052 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8170 | -0.7204 | -0.8341 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 765.58952 | 96.94 | -2.893 | -3.911 | -5.619 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.028 | -2.012 | 2.680 | 0.8613 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7550 | 0.8382 | 1.240 | 0.9583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8877 | 1.543 | 1.390 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 765.58952</span> | 96.94 | 0.05539 | 0.02003 | 0.003629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1163 | 0.1179 | 2.680 | 0.8613 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7550 | 0.8382 | 1.240 | 0.9583 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8877 | 1.543 | 1.390 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 765.32464 | 0.9995 | -0.9365 | -1.096 | -0.8851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8870 | -0.9350 | -0.2832 | -0.4460 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1644 | -0.8666 | -0.7446 | -1.045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8047 | -0.7076 | -0.8318 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 765.32464 | 96.95 | -2.891 | -3.933 | -5.585 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.010 | -2.014 | 2.693 | 0.8623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7598 | 0.8459 | 1.246 | 0.9668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8980 | 1.561 | 1.393 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 765.32464</span> | 96.95 | 0.05552 | 0.01958 | 0.003753 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1182 | 0.1177 | 2.693 | 0.8623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7598 | 0.8459 | 1.246 | 0.9668 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8980 | 1.561 | 1.393 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.84 | -0.1780 | 3.152 | -3.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.881 | -0.7435 | 0.7708 | -2.561 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.120 | 0.1753 | -2.364 | 2.891 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.893 | -3.031 | -0.9792 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 764.89127 | 1.001 | -0.9331 | -1.138 | -0.8186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9173 | -0.9304 | -0.2709 | -0.4365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1500 | -0.8575 | -0.7404 | -1.047 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7849 | -0.6971 | -0.8273 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 764.89127 | 97.05 | -2.888 | -3.975 | -5.519 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.073 | -2.005 | 2.706 | 0.8657 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7639 | 0.8536 | 1.250 | 0.9649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9146 | 1.575 | 1.399 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 764.89127</span> | 97.05 | 0.05571 | 0.01878 | 0.004011 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1117 | 0.1187 | 2.706 | 0.8657 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7639 | 0.8536 | 1.250 | 0.9649 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9146 | 1.575 | 1.399 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 19.26 | -0.1091 | 2.782 | -3.871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.068 | -0.03848 | 1.779 | -1.635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5035 | 0.4763 | -2.083 | 2.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.295 | -2.519 | -0.9166 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 764.86909 | 0.9949 | -0.9319 | -1.178 | -0.7471 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9138 | -0.9236 | -0.2803 | -0.4250 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1592 | -0.8601 | -0.7408 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7627 | -0.7028 | -0.8216 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 764.86909 | 96.51 | -2.886 | -4.015 | -5.447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.066 | -1.991 | 2.696 | 0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7613 | 0.8514 | 1.250 | 0.9401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9333 | 1.567 | 1.407 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 764.86909</span> | 96.51 | 0.05578 | 0.01803 | 0.004309 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1124 | 0.1201 | 2.696 | 0.8698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7613 | 0.8514 | 1.250 | 0.9401 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9333 | 1.567 | 1.407 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -169.3 | 0.02233 | 2.185 | -3.786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.443 | 0.4519 | 0.3349 | -0.6672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | 1.036 | -2.128 | -0.1909 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.017 | -2.598 | -0.8552 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 764.27620 | 1.001 | -0.9315 | -1.198 | -0.7106 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9112 | -0.9215 | -0.2834 | -0.4198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1627 | -0.8638 | -0.7423 | -1.077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7523 | -0.7079 | -0.8190 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 764.2762 | 97.07 | -2.886 | -4.035 | -5.411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.061 | -1.987 | 2.693 | 0.8716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7603 | 0.8483 | 1.248 | 0.9297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9421 | 1.560 | 1.410 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 764.2762</span> | 97.07 | 0.05580 | 0.01769 | 0.004469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1130 | 0.1206 | 2.693 | 0.8716 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7603 | 0.8483 | 1.248 | 0.9297 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9421 | 1.560 | 1.410 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.99 | -0.06591 | 1.982 | -3.655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.737 | 1.224 | 0.5238 | -0.1462 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.477 | 0.3446 | -2.258 | -1.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.063 | -3.016 | -0.8065 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 764.08600 | 0.9998 | -0.9318 | -1.216 | -0.6718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9105 | -0.9239 | -0.2868 | -0.4186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1661 | -0.8701 | -0.7420 | -1.077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7408 | -0.7119 | -0.8158 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 764.086 | 96.98 | -2.886 | -4.053 | -5.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.059 | -1.992 | 2.689 | 0.8721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7594 | 0.8430 | 1.249 | 0.9293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9517 | 1.555 | 1.415 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 764.086</span> | 96.98 | 0.05578 | 0.01738 | 0.004646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1131 | 0.1201 | 2.689 | 0.8721 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7594 | 0.8430 | 1.249 | 0.9293 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9517 | 1.555 | 1.415 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 763.68333 | 0.9997 | -0.9325 | -1.262 | -0.5698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9089 | -0.9302 | -0.2957 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1752 | -0.8867 | -0.7413 | -1.078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7108 | -0.7228 | -0.8074 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 763.68333 | 96.97 | -2.887 | -4.099 | -5.270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.056 | -2.004 | 2.680 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7568 | 0.8290 | 1.249 | 0.9281 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9770 | 1.540 | 1.426 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 763.68333</span> | 96.97 | 0.05574 | 0.01659 | 0.005145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1134 | 0.1187 | 2.680 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7568 | 0.8290 | 1.249 | 0.9281 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9770 | 1.540 | 1.426 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 763.23003 | 0.9993 | -0.9340 | -1.363 | -0.3486 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9055 | -0.9438 | -0.3150 | -0.4083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1949 | -0.9227 | -0.7397 | -1.080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6457 | -0.7464 | -0.7892 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 763.23003 | 96.93 | -2.889 | -4.200 | -5.049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.049 | -2.032 | 2.660 | 0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7513 | 0.7988 | 1.251 | 0.9256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.032 | 1.508 | 1.451 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 763.23003</span> | 96.93 | 0.05566 | 0.01500 | 0.006419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1142 | 0.1159 | 2.660 | 0.8757 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7513 | 0.7988 | 1.251 | 0.9256 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.032 | 1.508 | 1.451 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.00 | -0.1117 | 0.5708 | -1.597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5912 | -4.959 | -1.502 | 1.095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -1.786 | -1.932 | -2.056 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.026 | -5.307 | 0.1331 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 765.10598 | 0.9988 | -0.9419 | -1.481 | -0.006130 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9009 | -0.7845 | -0.3455 | -0.4625 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1991 | -0.9538 | -0.7488 | -1.046 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5215 | -0.7432 | -0.7830 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 765.10598 | 96.88 | -2.896 | -4.318 | -4.706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.039 | -1.713 | 2.628 | 0.8565 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 0.7726 | 1.241 | 0.9658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.136 | 1.513 | 1.459 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 765.10598</span> | 96.88 | 0.05522 | 0.01333 | 0.009040 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1152 | 0.1528 | 2.628 | 0.8565 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 0.7726 | 1.241 | 0.9658 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.136 | 1.513 | 1.459 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 763.02578 | 0.9999 | -0.9358 | -1.391 | -0.2684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9044 | -0.9064 | -0.3221 | -0.4211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1957 | -0.9299 | -0.7418 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6165 | -0.7455 | -0.7877 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 763.02578 | 96.99 | -2.890 | -4.228 | -4.968 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.957 | 2.652 | 0.8712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7511 | 0.7927 | 1.249 | 0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.056 | 1.510 | 1.452 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 763.02578</span> | 96.99 | 0.05556 | 0.01459 | 0.006954 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1144 | 0.1238 | 2.652 | 0.8712 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7511 | 0.7927 | 1.249 | 0.9351 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.056 | 1.510 | 1.452 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.557 | -0.1614 | 0.3205 | -0.9685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3267 | 2.395 | -2.389 | -0.1069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.595 | -2.113 | -2.097 | -1.406 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.821 | -5.218 | -0.7119 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 766.17797 | 1.015 | -0.9359 | -1.390 | -0.2436 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9043 | -0.9341 | -0.3009 | -0.4312 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1485 | -0.9049 | -0.7235 | -1.053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5884 | -0.6890 | -0.7788 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 766.17797 | 98.50 | -2.890 | -4.227 | -4.944 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -2.012 | 2.675 | 0.8676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7643 | 0.8138 | 1.269 | 0.9575 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.080 | 1.586 | 1.465 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 766.17797</span> | 98.50 | 0.05555 | 0.01460 | 0.007129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1144 | 0.1179 | 2.675 | 0.8676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7643 | 0.8138 | 1.269 | 0.9575 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.586 | 1.465 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 762.99023 | 1.002 | -0.9356 | -1.391 | -0.2672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9092 | -0.3192 | -0.4209 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1902 | -0.9274 | -0.7393 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6144 | -0.7393 | -0.7869 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.99023 | 97.17 | -2.890 | -4.228 | -4.967 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.963 | 2.655 | 0.8713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7526 | 0.7948 | 1.252 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.058 | 1.518 | 1.454 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.99023</span> | 97.17 | 0.05557 | 0.01458 | 0.006962 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1232 | 2.655 | 0.8713 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7526 | 0.7948 | 1.252 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.058 | 1.518 | 1.454 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 51.43 | -0.1841 | 0.3204 | -0.9603 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07939 | 1.931 | -1.965 | -0.1875 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.362 | -1.812 | -1.918 | -2.236 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.746 | -4.882 | -0.6715 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 762.91633 | 1.000 | -0.9363 | -1.389 | -0.2610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9054 | -0.9109 | -0.3206 | -0.4247 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1891 | -0.9263 | -0.7404 | -1.066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6100 | -0.7370 | -0.7858 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.91633 | 97.00 | -2.891 | -4.226 | -4.961 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.049 | -1.966 | 2.654 | 0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7529 | 0.7958 | 1.250 | 0.9417 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.062 | 1.521 | 1.455 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.91633</span> | 97.00 | 0.05553 | 0.01461 | 0.007006 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1142 | 0.1228 | 2.654 | 0.8699 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7529 | 0.7958 | 1.250 | 0.9417 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.062 | 1.521 | 1.455 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4218 | -0.1782 | 0.3230 | -0.9273 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6605 | 1.389 | -2.249 | -0.4385 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.981 | -1.888 | -1.963 | -0.6447 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.620 | -4.721 | -0.6578 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 762.84890 | 1.001 | -0.9361 | -1.390 | -0.2598 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9045 | -0.9128 | -0.3175 | -0.4241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1836 | -0.9236 | -0.7377 | -1.066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6077 | -0.7305 | -0.7849 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.8489 | 97.05 | -2.891 | -4.227 | -4.960 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.047 | -1.970 | 2.657 | 0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7544 | 0.7980 | 1.253 | 0.9427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.064 | 1.530 | 1.456 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.8489</span> | 97.05 | 0.05554 | 0.01460 | 0.007015 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1144 | 0.1224 | 2.657 | 0.8701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7544 | 0.7980 | 1.253 | 0.9427 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.064 | 1.530 | 1.456 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 762.76203 | 1.002 | -0.9355 | -1.391 | -0.2569 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | -0.9170 | -0.3107 | -0.4228 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1716 | -0.9179 | -0.7317 | -1.064 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6028 | -0.7161 | -0.7829 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.76203 | 97.18 | -2.890 | -4.228 | -4.957 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.978 | 2.664 | 0.8706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7578 | 0.8028 | 1.260 | 0.9450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.068 | 1.549 | 1.459 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.76203</span> | 97.18 | 0.05557 | 0.01459 | 0.007034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1215 | 2.664 | 0.8706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7578 | 0.8028 | 1.260 | 0.9450 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 | 1.549 | 1.459 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.31 | -0.1887 | 0.3021 | -0.9307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2254 | 0.1583 | -1.328 | -0.4242 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.868 | -1.362 | -1.371 | -0.08091 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.408 | -3.948 | -0.5076 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 762.67102 | 0.9998 | -0.9349 | -1.387 | -0.2432 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9003 | -0.9168 | -0.3029 | -0.4253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1712 | -0.9066 | -0.7353 | -1.085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5940 | -0.7040 | -0.7794 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.67102 | 96.98 | -2.889 | -4.224 | -4.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.038 | -1.978 | 2.672 | 0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7579 | 0.8123 | 1.256 | 0.9195 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.075 | 1.566 | 1.464 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.67102</span> | 96.98 | 0.05561 | 0.01464 | 0.007132 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1153 | 0.1216 | 2.672 | 0.8697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7579 | 0.8123 | 1.256 | 0.9195 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.075 | 1.566 | 1.464 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.974 | -0.1351 | 0.3572 | -0.8415 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6736 | -0.1073 | -0.7732 | -0.4654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.903 | -1.199 | -1.653 | -3.516 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.220 | -3.098 | -0.3193 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 762.64017 | 0.9999 | -0.9344 | -1.376 | -0.2262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9165 | -0.3113 | -0.4148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1768 | -0.8962 | -0.7385 | -1.074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5804 | -0.6983 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.64017 | 96.99 | -2.889 | -4.213 | -4.926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.664 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7564 | 0.8211 | 1.252 | 0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.087 | 1.573 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.64017</span> | 96.99 | 0.05564 | 0.01480 | 0.007254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1216 | 2.664 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7564 | 0.8211 | 1.252 | 0.9329 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.087 | 1.573 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.599 | -0.1184 | 0.4302 | -0.7157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5570 | -0.2072 | -1.823 | 0.1166 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.571 | -0.7852 | -1.969 | -1.423 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5877 | -2.399 | -0.03479 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 763.13274 | 1.006 | -0.9334 | -1.371 | -0.2107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9029 | -0.9149 | -0.3061 | -0.4144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1571 | -0.8894 | -0.7216 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5763 | -0.6939 | -0.7717 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 763.13274 | 97.59 | -2.888 | -4.208 | -4.911 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.043 | -1.974 | 2.669 | 0.8736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 0.8268 | 1.271 | 0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.090 | 1.579 | 1.474 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 763.13274</span> | 97.59 | 0.05569 | 0.01488 | 0.007367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1147 | 0.1220 | 2.669 | 0.8736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 0.8268 | 1.271 | 0.9397 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.090 | 1.579 | 1.474 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 762.63967 | 1.001 | -0.9343 | -1.377 | -0.2257 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9036 | -0.9164 | -0.3100 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1742 | -0.8956 | -0.7371 | -1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5800 | -0.6966 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.63967 | 97.10 | -2.889 | -4.214 | -4.926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.665 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7571 | 0.8216 | 1.254 | 0.9341 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.087 | 1.576 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.63967</span> | 97.10 | 0.05564 | 0.01479 | 0.007258 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1217 | 2.665 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7571 | 0.8216 | 1.254 | 0.9341 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.087 | 1.576 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.39 | -0.1342 | 0.4309 | -0.7057 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3094 | -0.07498 | -1.436 | 0.2859 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.195 | -0.5698 | -1.754 | -1.179 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7834 | -2.640 | -0.03401 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 762.61838 | 0.9999 | -0.9342 | -1.376 | -0.2247 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | -0.9164 | -0.3101 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1736 | -0.8955 | -0.7362 | -1.073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5799 | -0.6970 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.61838 | 96.99 | -2.889 | -4.213 | -4.925 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.665 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7573 | 0.8216 | 1.255 | 0.9344 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.087 | 1.575 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.61838</span> | 96.99 | 0.05564 | 0.01480 | 0.007265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1217 | 2.665 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7573 | 0.8216 | 1.255 | 0.9344 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.087 | 1.575 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.755 | -0.1162 | 0.4295 | -0.7030 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4902 | -0.1819 | -1.508 | 0.3366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.097 | -0.6862 | -1.700 | -1.138 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9036 | -2.963 | -0.05834 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 762.61305 | 1.000 | -0.9342 | -1.376 | -0.2240 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | -0.9164 | -0.3097 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1725 | -0.8955 | -0.7354 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5794 | -0.6961 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.61305 | 97.04 | -2.889 | -4.213 | -4.924 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.665 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7576 | 0.8217 | 1.256 | 0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.087 | 1.576 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.61305</span> | 97.04 | 0.05565 | 0.01480 | 0.007270 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1217 | 2.665 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7576 | 0.8217 | 1.256 | 0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.087 | 1.576 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 14.76 | -0.1238 | 0.4322 | -0.6935 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4217 | -0.1389 | -1.290 | 0.3261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.236 | -0.7060 | -1.644 | -1.160 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7164 | -2.626 | -0.06595 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 762.60623 | 0.9999 | -0.9342 | -1.376 | -0.2227 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9165 | -0.3102 | -0.4162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1716 | -0.8955 | -0.7347 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5791 | -0.6961 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.60623 | 96.99 | -2.889 | -4.213 | -4.923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.665 | 0.8729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7578 | 0.8216 | 1.257 | 0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.576 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.60623</span> | 96.99 | 0.05565 | 0.01481 | 0.007279 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1216 | 2.665 | 0.8729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7578 | 0.8216 | 1.257 | 0.9348 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.576 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.846 | -0.1151 | 0.4344 | -0.6824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5544 | -0.2171 | -1.375 | 0.3027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.857 | -0.6587 | -1.590 | -1.961 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8624 | -2.600 | -0.06827 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 762.60133 | 1.000 | -0.9341 | -1.375 | -0.2218 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9164 | -0.3101 | -0.4167 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1705 | -0.8954 | -0.7339 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5787 | -0.6957 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.60133 | 97.04 | -2.889 | -4.212 | -4.922 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.665 | 0.8727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7581 | 0.8217 | 1.258 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.577 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.60133</span> | 97.04 | 0.05565 | 0.01481 | 0.007286 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1216 | 2.665 | 0.8727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7581 | 0.8217 | 1.258 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.577 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.48 | -0.1210 | 0.4371 | -0.6694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4912 | -0.1711 | -1.470 | 0.1448 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.873 | -0.6387 | -1.543 | -1.867 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7020 | -2.876 | -0.07344 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 762.59465 | 0.9999 | -0.9341 | -1.375 | -0.2207 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9164 | -0.3095 | -0.4173 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1704 | -0.8960 | -0.7329 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5790 | -0.6956 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.59465 | 96.99 | -2.889 | -4.212 | -4.921 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.666 | 0.8726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7582 | 0.8213 | 1.259 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.577 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.59465</span> | 96.99 | 0.05565 | 0.01482 | 0.007294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1216 | 2.666 | 0.8726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7582 | 0.8213 | 1.259 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.577 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.775 | -0.1124 | 0.4366 | -0.6552 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5921 | -0.2206 | -1.396 | 0.1541 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.894 | -0.7001 | -1.461 | -0.9904 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8842 | -2.566 | -0.07283 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 762.59066 | 1.000 | -0.9340 | -1.375 | -0.2198 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9038 | -0.9163 | -0.3089 | -0.4174 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1692 | -0.8959 | -0.7322 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5787 | -0.6947 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.59066 | 97.04 | -2.889 | -4.212 | -4.920 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.977 | 2.666 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7585 | 0.8213 | 1.259 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.578 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.59066</span> | 97.04 | 0.05566 | 0.01482 | 0.007300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.666 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7585 | 0.8213 | 1.259 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.578 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.18 | -0.1194 | 0.4391 | -0.6416 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4865 | -0.1542 | -1.319 | 0.1335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.691 | -0.6283 | -1.400 | -0.9220 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7113 | -2.508 | -0.07019 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 762.58429 | 0.9999 | -0.9339 | -1.375 | -0.2184 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9163 | -0.3092 | -0.4175 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1684 | -0.8956 | -0.7319 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5779 | -0.6949 | -0.7734 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.58429 | 96.99 | -2.888 | -4.212 | -4.918 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.666 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7587 | 0.8216 | 1.260 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.578 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.58429</span> | 96.99 | 0.05566 | 0.01482 | 0.007311 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.666 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7587 | 0.8216 | 1.260 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.578 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.054 | -0.1077 | 0.4392 | -0.6327 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5920 | -0.2170 | -1.368 | 0.1202 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.662 | -0.6439 | -1.388 | -1.754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8733 | -2.532 | -0.1003 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 762.57982 | 1.000 | -0.9338 | -1.375 | -0.2170 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9162 | -0.3086 | -0.4176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1676 | -0.8956 | -0.7312 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5773 | -0.6947 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.57982 | 97.02 | -2.888 | -4.212 | -4.917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.666 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7589 | 0.8216 | 1.261 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.578 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.57982</span> | 97.02 | 0.05567 | 0.01482 | 0.007321 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.666 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7589 | 0.8216 | 1.261 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.578 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.173 | -0.1105 | 0.4413 | -0.6162 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5474 | -0.1732 | -1.159 | 0.1830 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.846 | -0.7034 | -1.343 | -0.9047 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6908 | -2.510 | -0.09661 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 762.57572 | 0.9999 | -0.9337 | -1.375 | -0.2157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9162 | -0.3092 | -0.4178 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1663 | -0.8953 | -0.7312 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5771 | -0.6947 | -0.7731 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.57572 | 96.99 | -2.888 | -4.212 | -4.916 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.666 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7593 | 0.8218 | 1.261 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.578 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.57572</span> | 96.99 | 0.05567 | 0.01482 | 0.007331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.666 | 0.8724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7593 | 0.8218 | 1.261 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.578 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.338 | -0.1030 | 0.4402 | -0.6028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6140 | -0.2137 | -1.433 | 0.08084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.656 | -0.6680 | -1.346 | -1.715 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8965 | -2.853 | -0.1247 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 762.57150 | 1.000 | -0.9337 | -1.375 | -0.2145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9040 | -0.9162 | -0.3094 | -0.4180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1650 | -0.8953 | -0.7314 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5771 | -0.6938 | -0.7730 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.5715 | 97.02 | -2.888 | -4.212 | -4.915 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.977 | 2.666 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7597 | 0.8218 | 1.260 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.579 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.5715</span> | 97.02 | 0.05568 | 0.01482 | 0.007339 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.666 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7597 | 0.8218 | 1.260 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.579 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.917 | -0.1081 | 0.4404 | -0.5845 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.1795 | -1.372 | 0.08332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.404 | -0.6107 | -1.343 | -1.668 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7053 | -2.471 | -0.08527 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 762.56652 | 0.9998 | -0.9337 | -1.375 | -0.2137 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9161 | -0.3083 | -0.4179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1654 | -0.8958 | -0.7313 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5775 | -0.6927 | -0.7729 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.56652 | 96.98 | -2.888 | -4.212 | -4.914 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.976 | 2.667 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7596 | 0.8214 | 1.260 | 0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.581 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.56652</span> | 96.98 | 0.05568 | 0.01482 | 0.007345 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.667 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7596 | 0.8214 | 1.260 | 0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.581 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.202 | -0.09986 | 0.4343 | -0.5734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5963 | -0.2059 | -1.230 | 0.1366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.439 | -0.6793 | -1.344 | -1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8864 | -2.392 | -0.08042 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 762.56246 | 1.000 | -0.9336 | -1.375 | -0.2125 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9160 | -0.3073 | -0.4180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1656 | -0.8955 | -0.7303 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5773 | -0.6925 | -0.7730 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.56246 | 97.01 | -2.888 | -4.212 | -4.913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.976 | 2.668 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7595 | 0.8216 | 1.262 | 0.9386 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.581 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.56246</span> | 97.01 | 0.05568 | 0.01481 | 0.007354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1217 | 2.668 | 0.8723 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7595 | 0.8216 | 1.262 | 0.9386 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.581 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.335 | -0.1021 | 0.4320 | -0.5553 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5609 | -0.1614 | -1.231 | 0.02142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.620 | -0.6772 | -1.305 | -1.580 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7609 | -2.720 | -0.1132 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 762.55730 | 0.9999 | -0.9335 | -1.376 | -0.2115 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | -0.9159 | -0.3071 | -0.4174 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1649 | -0.8958 | -0.7301 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5781 | -0.6915 | -0.7731 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.5573 | 96.99 | -2.888 | -4.213 | -4.912 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.976 | 2.668 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7597 | 0.8214 | 1.262 | 0.9390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.089 | 1.583 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.5573</span> | 96.99 | 0.05568 | 0.01481 | 0.007361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1218 | 2.668 | 0.8725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7597 | 0.8214 | 1.262 | 0.9390 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.089 | 1.583 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 762.55308 | 1.000 | -0.9335 | -1.376 | -0.2104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9036 | -0.9158 | -0.3069 | -0.4167 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1644 | -0.8961 | -0.7300 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5790 | -0.6904 | -0.7733 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.55308 | 97.00 | -2.888 | -4.213 | -4.910 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.976 | 2.668 | 0.8727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7598 | 0.8211 | 1.262 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.584 | 1.472 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.55308</span> | 97.00 | 0.05568 | 0.01480 | 0.007369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1146 | 0.1218 | 2.668 | 0.8727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7598 | 0.8211 | 1.262 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.584 | 1.472 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 762.54129 | 1.000 | -0.9334 | -1.378 | -0.2065 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9033 | -0.9153 | -0.3062 | -0.4144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1625 | -0.8972 | -0.7297 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5824 | -0.6868 | -0.7739 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.54129 | 97.02 | -2.888 | -4.215 | -4.907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.044 | -1.975 | 2.669 | 0.8736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7604 | 0.8202 | 1.262 | 0.9405 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.085 | 1.589 | 1.471 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.54129</span> | 97.02 | 0.05569 | 0.01477 | 0.007398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1147 | 0.1219 | 2.669 | 0.8736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7604 | 0.8202 | 1.262 | 0.9405 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.085 | 1.589 | 1.471 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 762.53205 | 1.001 | -0.9333 | -1.381 | -0.1995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9026 | -0.9144 | -0.3049 | -0.4101 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1590 | -0.8993 | -0.7291 | -1.066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5885 | -0.6801 | -0.7749 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.53205 | 97.07 | -2.888 | -4.218 | -4.899 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.043 | -1.973 | 2.670 | 0.8751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7613 | 0.8185 | 1.263 | 0.9425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.080 | 1.598 | 1.470 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.53205</span> | 97.07 | 0.05570 | 0.01472 | 0.007451 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1221 | 2.670 | 0.8751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7613 | 0.8185 | 1.263 | 0.9425 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.598 | 1.470 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.65 | -0.1039 | 0.3653 | -0.2919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1880 | 0.2896 | -0.9107 | 0.7013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.202 | -0.8082 | -1.198 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.416 | -1.756 | -0.2090 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 762.48327 | 0.9998 | -0.9329 | -1.391 | -0.1822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9041 | -0.9140 | -0.3019 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1512 | -0.8995 | -0.7234 | -1.064 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5784 | -0.6773 | -0.7751 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.48327 | 96.98 | -2.887 | -4.228 | -4.882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.046 | -1.972 | 2.674 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7635 | 0.8183 | 1.269 | 0.9450 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.088 | 1.602 | 1.470 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.48327</span> | 96.98 | 0.05572 | 0.01458 | 0.007580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1222 | 2.674 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7635 | 0.8183 | 1.269 | 0.9450 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.602 | 1.470 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.920 | -0.08029 | 0.2756 | -0.1231 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7850 | 0.1611 | -0.6966 | 0.2967 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.718 | -0.8812 | -0.8270 | -0.2301 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.116 | -1.224 | -0.3843 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 762.47327 | 1.000 | -0.9318 | -1.401 | -0.1764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9027 | -0.9109 | -0.3019 | -0.4099 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1415 | -0.8907 | -0.7247 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5685 | -0.6781 | -0.7620 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.47327 | 97.01 | -2.886 | -4.238 | -4.876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.043 | -1.966 | 2.673 | 0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7662 | 0.8257 | 1.268 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.097 | 1.601 | 1.487 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.47327</span> | 97.01 | 0.05578 | 0.01443 | 0.007624 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1228 | 2.673 | 0.8752 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7662 | 0.8257 | 1.268 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.097 | 1.601 | 1.487 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.304 | -0.04991 | 0.1861 | -0.1521 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2758 | 0.6987 | -0.6385 | 0.6999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.104 | -0.4937 | -0.9023 | -1.218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.007 | -1.649 | 0.3798 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 762.45236 | 1.000 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | -0.9126 | -0.3007 | -0.4145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1407 | -0.8864 | -0.7274 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5562 | -0.6663 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45236 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45236</span> | 97.00 | 0.05580 | 0.01423 | 0.007643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1225 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.090 | -0.03836 | 0.07211 | -0.1660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2360 | 0.2575 | -0.5787 | 0.3648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.053 | -0.3652 | -1.069 | -1.349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4799 | -1.042 | -0.1902 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 762.47705 | 0.9990 | -0.9326 | -1.425 | -0.1717 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9039 | -0.9116 | -0.2960 | -0.4278 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1499 | -0.8783 | -0.6879 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5536 | -0.6497 | -0.7536 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.47705 | 96.90 | -2.887 | -4.262 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.045 | -1.967 | 2.680 | 0.8688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7639 | 0.8361 | 1.309 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.639 | 1.499 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.47705</span> | 96.90 | 0.05574 | 0.01410 | 0.007660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1145 | 0.1227 | 2.680 | 0.8688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7639 | 0.8361 | 1.309 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.639 | 1.499 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 762.47045 | 0.9985 | -0.9319 | -1.419 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9029 | -0.9123 | -0.2988 | -0.4194 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1437 | -0.8834 | -0.7128 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5551 | -0.6600 | -0.7636 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.47045 | 96.85 | -2.886 | -4.256 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.043 | -1.969 | 2.677 | 0.8718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7656 | 0.8318 | 1.281 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.625 | 1.485 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.47045</span> | 96.85 | 0.05578 | 0.01418 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1147 | 0.1225 | 2.677 | 0.8718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7656 | 0.8318 | 1.281 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.625 | 1.485 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 762.49004 | 0.9982 | -0.9315 | -1.417 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | -0.9126 | -0.3000 | -0.4160 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1412 | -0.8855 | -0.7230 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5558 | -0.6642 | -0.7677 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.49004 | 96.83 | -2.886 | -4.254 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.043 | -1.969 | 2.675 | 0.8730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7663 | 0.8301 | 1.270 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.619 | 1.480 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.49004</span> | 96.83 | 0.05579 | 0.01421 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1225 | 2.675 | 0.8730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7663 | 0.8301 | 1.270 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.619 | 1.480 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 762.45852 | 0.9993 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3006 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1405 | -0.8864 | -0.7272 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5561 | -0.6661 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45852 | 96.93 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45852</span> | 96.93 | 0.05580 | 0.01423 | 0.007643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 762.45201 | 0.9999 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | -0.9126 | -0.3007 | -0.4145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1407 | -0.8864 | -0.7274 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5562 | -0.6663 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45201 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45201</span> | 96.99 | 0.05580 | 0.01423 | 0.007643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1225 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9352 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.157 | -0.03565 | 0.07096 | -0.1676 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2565 | 0.2382 | -0.5340 | 0.4141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.202 | -0.3942 | -1.048 | -1.363 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4633 | -1.025 | -0.1715 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 762.45163 | 1.000 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | -0.9127 | -0.3007 | -0.4145 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1406 | -0.8864 | -0.7273 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5562 | -0.6662 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45163 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45163</span> | 97.00 | 0.05580 | 0.01423 | 0.007643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1225 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9353 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.387 | -0.03697 | 0.07095 | -0.1670 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2405 | 0.2417 | -0.4946 | 0.4249 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9410 | -0.3603 | -1.076 | -0.6985 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5549 | -0.6934 | -0.1964 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 762.45142 | 0.9999 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3006 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1405 | -0.8864 | -0.7272 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5561 | -0.6662 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45142 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45142</span> | 96.99 | 0.05580 | 0.01423 | 0.007643 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8293 | 1.265 | 0.9354 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.093 | -0.03511 | 0.07006 | -0.1682 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2501 | 0.2258 | -0.7319 | 0.2456 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.092 | -0.3868 | -1.095 | -0.7218 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5798 | -0.7078 | -0.2098 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 762.45106 | 1.000 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3006 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1405 | -0.8863 | -0.7271 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5561 | -0.6661 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45106 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.969 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8294 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45106</span> | 97.00 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7665 | 0.8294 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.558 | -0.03666 | 0.07079 | -0.1670 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2292 | 0.2352 | -0.6822 | 0.2833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9877 | -0.3599 | -1.086 | -0.7040 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5476 | -0.6798 | -0.1950 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 762.45087 | 0.9999 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3005 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1404 | -0.8863 | -0.7270 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5561 | -0.6661 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45087 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45087</span> | 96.99 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.701 | -0.06138 | 0.06188 | -0.1824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3275 | 0.1556 | -0.5644 | 0.4107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9451 | -0.3602 | -1.050 | -0.9219 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7692 | -0.8400 | -0.2110 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 762.45052 | 1.000 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3005 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1404 | -0.8863 | -0.7269 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5560 | -0.6660 | -0.7693 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45052 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45052</span> | 97.00 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.310 | -0.03660 | 0.07022 | -0.1677 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2216 | 0.2281 | -0.6223 | 0.3362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.101 | -0.3801 | -1.032 | -1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4655 | -1.018 | -0.1777 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 762.45025 | 0.9999 | -0.9314 | -1.416 | -0.1739 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3005 | -0.4146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1403 | -0.8862 | -0.7268 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5560 | -0.6659 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45025 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45025</span> | 96.99 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8294 | 1.265 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.564 | -0.03511 | 0.06930 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2301 | 0.2148 | -0.6958 | 0.2956 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.074 | -0.3641 | -1.039 | -0.6647 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5492 | -0.6891 | -0.2028 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 762.44994 | 1.000 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3004 | -0.4147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1402 | -0.8862 | -0.7268 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5559 | -0.6659 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44994 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44994</span> | 97.00 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9357 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.130 | -0.03693 | 0.06970 | -0.1678 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2087 | 0.2222 | -0.4767 | 0.4303 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.3788 | -1.043 | -1.360 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5474 | -0.6760 | -0.1925 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 762.44969 | 0.9999 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9024 | -0.9127 | -0.3004 | -0.4147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1402 | -0.8862 | -0.7266 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5559 | -0.6658 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44969 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9358 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.477 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44969</span> | 96.99 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9358 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.477 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.483 | -0.03492 | 0.06900 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2211 | 0.2086 | -0.7093 | 0.2512 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9848 | -0.3396 | -1.026 | -1.317 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5572 | -0.6715 | -0.1875 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 762.44936 | 1.000 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3003 | -0.4147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1401 | -0.8862 | -0.7266 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5558 | -0.6658 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44936 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44936</span> | 97.00 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1148 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7666 | 0.8295 | 1.266 | 0.9359 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.828 | -0.03668 | 0.06906 | -0.1681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2025 | 0.2148 | -0.4016 | 0.4562 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7985 | -0.3199 | -1.005 | -0.6242 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4649 | -1.017 | -0.1851 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 762.44920 | 0.9998 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3003 | -0.4147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1401 | -0.8861 | -0.7265 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5558 | -0.6657 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4492 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8295 | 1.266 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4492</span> | 96.99 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8295 | 1.266 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.892 | -0.06089 | 0.06027 | -0.1834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3033 | 0.1350 | -0.5226 | 0.3403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9268 | -0.3802 | -1.004 | -0.8849 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7517 | -0.8245 | -0.1920 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 762.44881 | 1.000 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3003 | -0.4147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1400 | -0.8861 | -0.7264 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5558 | -0.6656 | -0.7692 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44881 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.617 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44881</span> | 97.00 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9360 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.617 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.278 | -0.03606 | 0.06873 | -0.1684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1982 | 0.2076 | -0.7410 | 0.2864 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9371 | -0.3600 | -0.9981 | -0.6148 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4567 | -0.9956 | -0.1730 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 762.44861 | 0.9999 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3002 | -0.4148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1400 | -0.8861 | -0.7263 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5557 | -0.6656 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44861 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44861</span> | 96.99 | 0.05580 | 0.01423 | 0.007644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.918 | -0.03426 | 0.06810 | -0.1693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2072 | 0.1939 | -0.5108 | 0.4012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.125 | -0.3956 | -1.016 | -0.6465 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5398 | -0.6520 | -0.1791 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 762.44831 | 1.000 | -0.9314 | -1.416 | -0.1738 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3002 | -0.4148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1399 | -0.8861 | -0.7262 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5557 | -0.6655 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44831 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44831</span> | 97.00 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.263 | -0.03657 | 0.06844 | -0.1684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1851 | 0.2030 | -0.3956 | 0.5081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.042 | -0.3769 | -0.9733 | -0.5979 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4511 | -0.9881 | -0.1717 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 762.44807 | 0.9999 | -0.9314 | -1.416 | -0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3002 | -0.4148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1398 | -0.8860 | -0.7261 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5557 | -0.6655 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44807 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44807</span> | 96.99 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8296 | 1.266 | 0.9361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.676 | -0.03430 | 0.06789 | -0.1692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2001 | 0.1879 | -0.6345 | 0.2243 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9985 | -0.3646 | -0.9895 | -0.6233 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5267 | -0.6582 | -0.1873 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 762.44780 | 1.000 | -0.9314 | -1.416 | -0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3001 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1398 | -0.8860 | -0.7261 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5556 | -0.6654 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4478 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8297 | 1.266 | 0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4478</span> | 97.00 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8297 | 1.266 | 0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.318 | -0.03631 | 0.06808 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1789 | 0.1959 | -0.7173 | 0.2475 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9453 | -0.3416 | -0.9621 | -0.5903 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4826 | -0.9880 | -0.1748 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 762.44757 | 0.9999 | -0.9314 | -1.416 | -0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9023 | -0.9128 | -0.3001 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1397 | -0.8860 | -0.7260 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5556 | -0.6653 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44757 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8297 | 1.266 | 0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.107 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44757</span> | 96.99 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.8297 | 1.266 | 0.9362 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.403 | -0.03410 | 0.06766 | -0.1693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1923 | 0.1827 | -0.5754 | 0.3333 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.3445 | -0.9634 | -0.5940 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4852 | -0.9871 | -0.1745 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 762.44726 | 1.000 | -0.9314 | -1.416 | -0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.3000 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1396 | -0.8859 | -0.7259 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5555 | -0.6653 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44726 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.266 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44726</span> | 97.00 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.675 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.266 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.060 | -0.03580 | 0.06800 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1728 | 0.1899 | -0.4704 | 0.4284 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9227 | -0.3505 | -0.9813 | -0.6228 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5193 | -0.6388 | -0.1848 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 762.44712 | 0.9998 | -0.9314 | -1.416 | -0.1737 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.3000 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1396 | -0.8859 | -0.7258 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5555 | -0.6652 | -0.7691 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44712 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.267 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44712</span> | 96.99 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.267 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.853 | -0.06042 | 0.05902 | -0.1840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2766 | 0.1092 | -0.5247 | 0.3320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8590 | -0.3265 | -0.9669 | -0.8543 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7362 | -0.6424 | -0.1982 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 762.44677 | 1.000 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.3000 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1396 | -0.8859 | -0.7257 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5555 | -0.6652 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44677 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.267 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44677</span> | 97.00 | 0.05580 | 0.01423 | 0.007645 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8297 | 1.267 | 0.9363 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.229 | -0.03534 | 0.06769 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1722 | 0.1825 | -0.6577 | 0.2295 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9683 | -0.3540 | -0.9833 | -0.6305 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5492 | -0.6462 | -0.1881 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 762.44660 | 0.9999 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2999 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1395 | -0.8858 | -0.7256 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5554 | -0.6651 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4466 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4466</span> | 96.99 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.619 | -0.06037 | 0.05887 | -0.1840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2697 | 0.1047 | -0.4880 | 0.3107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8777 | -0.3347 | -0.9510 | -0.8415 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8070 | -0.6380 | -0.2003 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 762.44631 | 1.000 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2999 | -0.4149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1395 | -0.8858 | -0.7255 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5554 | -0.6651 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44631 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44631</span> | 97.00 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9364 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.239 | -0.03523 | 0.06754 | -0.1690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1652 | 0.1779 | -0.5810 | 0.3500 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9310 | -0.3299 | -0.9168 | -0.5544 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4590 | -0.9780 | -0.1676 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 762.44612 | 0.9999 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2998 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1394 | -0.8858 | -0.7254 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5553 | -0.6650 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44612 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44612</span> | 96.99 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.595 | -0.06025 | 0.05873 | -0.1842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2631 | 0.1003 | -0.4975 | 0.3199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.3517 | -0.9324 | -0.8365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7469 | -0.7872 | -0.1921 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 762.44579 | 1.000 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2998 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1394 | -0.8858 | -0.7253 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5553 | -0.6649 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44579 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44579</span> | 97.00 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7668 | 0.8298 | 1.267 | 0.9365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.332 | -0.03503 | 0.06745 | -0.1690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1595 | 0.1733 | -0.6521 | 0.2265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -0.3762 | -1.004 | -0.8055 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5808 | -0.6379 | -0.1715 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 762.44562 | 0.9999 | -0.9314 | -1.416 | -0.1736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2997 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1393 | -0.8857 | -0.7252 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5552 | -0.6649 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44562 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.618 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44562</span> | 96.99 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.618 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.540 | -0.06014 | 0.05853 | -0.1843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2582 | 0.09555 | -0.4805 | 0.3174 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8832 | -0.3610 | -0.9182 | -0.8220 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7344 | -0.7852 | -0.1863 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 762.44533 | 1.000 | -0.9314 | -1.416 | -0.1735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2997 | -0.4150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1393 | -0.8857 | -0.7251 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5552 | -0.6648 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44533 | 97.00 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44533</span> | 97.00 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.707 | -0.03519 | 0.06722 | -0.1691 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1517 | 0.1695 | -0.2998 | 0.5346 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9157 | -0.3444 | -0.9296 | -0.7244 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4238 | -0.9503 | -0.1555 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 762.44512 | 0.9999 | -0.9314 | -1.416 | -0.1735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9022 | -0.9129 | -0.2997 | -0.4151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1392 | -0.8857 | -0.7250 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5551 | -0.6647 | -0.7690 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44512 | 96.99 | -2.886 | -4.253 | -4.874 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44512</span> | 96.99 | 0.05580 | 0.01423 | 0.007646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.267 | 0.9367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.725 | -0.03313 | 0.06674 | -0.1698 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1647 | 0.1564 | -0.4671 | 0.3596 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.122 | -0.3749 | -0.8900 | -0.5488 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4408 | -0.9435 | -0.1591 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 762.44482 | 1.000 | -0.9314 | -1.416 | -0.1735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9129 | -0.2997 | -0.4151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1391 | -0.8856 | -0.7249 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5551 | -0.6647 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44482 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.268 | 0.9367 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44482</span> | 97.00 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8299 | 1.268 | 0.9367 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.165 | -0.03526 | 0.06705 | -0.1689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1452 | 0.1649 | -0.6916 | 0.2043 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.053 | -0.3782 | -0.9414 | -1.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4339 | -0.9640 | -0.1678 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 762.44457 | 0.9999 | -0.9314 | -1.416 | -0.1735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9129 | -0.2997 | -0.4151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1391 | -0.8856 | -0.7248 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5551 | -0.6646 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44457 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8300 | 1.268 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44457</span> | 96.99 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8300 | 1.268 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.241 | -0.03355 | 0.06646 | -0.1694 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1600 | 0.1522 | -0.4229 | 0.3779 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8707 | -0.3333 | -0.8636 | -0.5164 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4114 | -0.9432 | -0.1630 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 762.44429 | 1.000 | -0.9314 | -1.416 | -0.1734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2996 | -0.4151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1390 | -0.8856 | -0.7247 | -1.071 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5551 | -0.6645 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44429 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8300 | 1.268 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44429</span> | 97.00 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7669 | 0.8300 | 1.268 | 0.9368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.194 | -0.03535 | 0.06668 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1413 | 0.1590 | -0.5714 | 0.3381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9309 | -0.3230 | -0.9277 | -0.7053 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4161 | -0.9324 | -0.1528 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 762.44403 | 0.9999 | -0.9314 | -1.416 | -0.1734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2996 | -0.4152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1390 | -0.8855 | -0.7246 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5550 | -0.6645 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44403 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8300 | 1.268 | 0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44403</span> | 96.99 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8300 | 1.268 | 0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.197 | -0.03347 | 0.06628 | -0.1692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1562 | 0.1463 | -0.5532 | 0.2989 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9647 | -0.3192 | -0.9128 | -0.7175 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4587 | -0.9463 | -0.1607 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 762.44374 | 1.000 | -0.9314 | -1.416 | -0.1734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2996 | -0.4152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1389 | -0.8855 | -0.7245 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5550 | -0.6644 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44374 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44374</span> | 97.00 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9369 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.963 | -0.03502 | 0.06649 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1388 | 0.1528 | -0.5508 | 0.3111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7878 | -0.3058 | -0.9061 | -0.7073 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4580 | -0.9428 | -0.1693 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 762.44359 | 0.9999 | -0.9314 | -1.416 | -0.1734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2995 | -0.4152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1389 | -0.8855 | -0.7244 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5550 | -0.6643 | -0.7689 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44359 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44359</span> | 96.99 | 0.05580 | 0.01423 | 0.007647 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.684 | -0.05996 | 0.05741 | -0.1839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2433 | 0.07318 | -0.4825 | 0.3221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8461 | -0.3440 | -0.8674 | -0.7797 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7318 | -0.7544 | -0.1758 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 762.44327 | 1.000 | -0.9314 | -1.416 | -0.1734 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2995 | -0.4153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1389 | -0.8855 | -0.7243 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5549 | -0.6642 | -0.7688 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44327 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44327</span> | 97.00 | 0.05580 | 0.01423 | 0.007648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9370 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.433 | -0.03457 | 0.06633 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1378 | 0.1478 | -0.5721 | 0.2715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9861 | -0.3308 | -0.8969 | -0.7064 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4388 | -0.9204 | -0.1570 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 762.44310 | 0.9999 | -0.9314 | -1.416 | -0.1733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2994 | -0.4153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1388 | -0.8854 | -0.7242 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5549 | -0.6642 | -0.7688 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4431 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.619 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4431</span> | 96.99 | 0.05580 | 0.01423 | 0.007648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.619 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.488 | -0.05983 | 0.05732 | -0.1840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2388 | 0.07017 | -0.4805 | 0.5027 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8122 | -0.3072 | -0.8597 | -0.7873 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7191 | -0.5849 | -0.1893 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 762.44280 | 1.000 | -0.9314 | -1.416 | -0.1733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2994 | -0.4153 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1388 | -0.8854 | -0.7241 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.6641 | -0.7688 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4428 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4428</span> | 97.00 | 0.05580 | 0.01423 | 0.007648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8301 | 1.268 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.618 | -0.03464 | 0.06615 | -0.1687 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1343 | 0.1439 | -0.4410 | 0.3116 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7529 | -0.3320 | -0.8865 | -0.6978 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4222 | -0.9084 | -0.1490 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 762.44259 | 0.9999 | -0.9314 | -1.416 | -0.1733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2994 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1387 | -0.8854 | -0.7240 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.6640 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44259 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44259</span> | 96.99 | 0.05580 | 0.01423 | 0.007648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.481 | -0.03300 | 0.06550 | -0.1695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1475 | 0.1316 | -0.5909 | 0.2411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9770 | -0.3768 | -0.8670 | -1.331 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4247 | -0.9107 | -0.1525 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 762.44225 | 1.000 | -0.9314 | -1.416 | -0.1733 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2993 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1387 | -0.8853 | -0.7239 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.6639 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44225 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44225</span> | 97.00 | 0.05580 | 0.01423 | 0.007648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9372 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.420 | -0.03457 | 0.06572 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1336 | 0.1386 | -0.4202 | 0.2852 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9190 | -0.3266 | -0.8656 | -0.6768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4245 | -0.9083 | -0.1511 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 762.44213 | 0.9998 | -0.9314 | -1.416 | -0.1732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2993 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1386 | -0.8853 | -0.7238 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5547 | -0.6639 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44213 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44213</span> | 96.99 | 0.05580 | 0.01423 | 0.007649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7670 | 0.8302 | 1.269 | 0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.863 | -0.05945 | 0.05668 | -0.1838 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2350 | 0.05997 | -0.4163 | 0.3221 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8675 | -0.3570 | -0.8347 | -0.7546 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7945 | -0.5713 | -0.1981 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 762.44181 | 1.000 | -0.9314 | -1.416 | -0.1732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9021 | -0.9130 | -0.2993 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1386 | -0.8853 | -0.7237 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5547 | -0.6638 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44181 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8302 | 1.269 | 0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44181</span> | 97.00 | 0.05580 | 0.01423 | 0.007649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8302 | 1.269 | 0.9373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.253 | -0.03424 | 0.06574 | -0.1683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1309 | 0.1341 | -0.5651 | 0.1807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -0.3557 | -0.8957 | -0.7064 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5151 | -0.5648 | -0.1753 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 762.44169 | 0.9999 | -0.9314 | -1.416 | -0.1732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9130 | -0.2993 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1385 | -0.8853 | -0.7236 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5547 | -0.6638 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44169 | 96.99 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44169</span> | 96.99 | 0.05581 | 0.01423 | 0.007649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.696 | -0.05943 | 0.05667 | -0.1838 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2311 | 0.05629 | -0.4589 | 0.3239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8257 | -0.3368 | -0.8102 | -0.7513 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7185 | -0.5600 | -0.1932 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 762.44142 | 1.000 | -0.9314 | -1.416 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9130 | -0.2992 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1385 | -0.8852 | -0.7235 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5546 | -0.6637 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44142 | 97.00 | -2.886 | -4.253 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44142</span> | 97.00 | 0.05581 | 0.01423 | 0.007649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9374 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.335 | -0.03441 | 0.06556 | -0.1684 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1266 | 0.1302 | -0.6103 | 0.1783 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.044 | -0.3387 | -0.8638 | -1.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5275 | -0.5670 | -0.1757 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 762.44125 | 0.9999 | -0.9314 | -1.415 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2992 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1384 | -0.8852 | -0.7234 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5545 | -0.6637 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44125 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.042 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44125</span> | 96.99 | 0.05581 | 0.01423 | 0.007649 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9375 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.098 | -0.05964 | 0.05680 | -0.1834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2254 | 0.05544 | -0.4561 | 0.3185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8411 | -0.2737 | -0.7922 | -0.7469 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7250 | -0.5635 | -0.1902 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 762.44108 | 1.000 | -0.9314 | -1.415 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2992 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1384 | -0.8852 | -0.7233 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5545 | -0.6636 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44108 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44108</span> | 97.00 | 0.05581 | 0.01423 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 2.161 | -0.06174 | 0.05743 | -0.1824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2028 | 0.06759 | -0.4445 | 0.3255 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8755 | -0.3449 | -0.7930 | -0.7294 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7121 | -0.5628 | -0.1899 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 762.44087 | 0.9999 | -0.9313 | -1.415 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2991 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1383 | -0.8852 | -0.7232 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5544 | -0.6636 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44087 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.108 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44087</span> | 96.99 | 0.05581 | 0.01423 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 0.8303 | 1.269 | 0.9376 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.108 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8905 | -0.03259 | 0.06518 | -0.1692 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1290 | 0.1190 | -0.3929 | 0.3938 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7338 | -0.2959 | -0.8056 | -1.276 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4089 | -0.8806 | -0.1497 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 762.44057 | 1.000 | -0.9313 | -1.415 | -0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2991 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1383 | -0.8852 | -0.7232 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5544 | -0.6635 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44057 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.269 | 0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44057</span> | 97.00 | 0.05581 | 0.01423 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.269 | 0.9377 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.554 | -0.03385 | 0.06512 | -0.1686 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1157 | 0.1237 | -0.6002 | 0.2113 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9800 | -0.3598 | -0.8363 | -0.6768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4936 | -0.5534 | -0.1651 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 762.44050 | 0.9998 | -0.9313 | -1.415 | -0.1730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2991 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1382 | -0.8851 | -0.7231 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5543 | -0.6635 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4405 | 96.98 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4405</span> | 96.98 | 0.05581 | 0.01423 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.676 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -3.014 | -0.05852 | 0.05608 | -0.1841 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2187 | 0.04463 | -0.4314 | 0.3139 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8150 | -0.2938 | -0.7775 | -0.7094 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7099 | -0.5560 | -0.1738 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 762.44022 | 1.000 | -0.9313 | -1.415 | -0.1730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2990 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1382 | -0.8851 | -0.7230 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5543 | -0.6634 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44022 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.620 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44022</span> | 97.00 | 0.05581 | 0.01423 | 0.007650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9378 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.620 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.178 | -0.03363 | 0.06507 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1131 | 0.1194 | -0.3125 | 0.3718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7445 | -0.2864 | -0.7962 | -1.246 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4203 | -0.8863 | -0.1505 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 762.44004 | 0.9999 | -0.9313 | -1.415 | -0.1730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2990 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1381 | -0.8851 | -0.7229 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5542 | -0.6634 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44004 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44004</span> | 96.99 | 0.05581 | 0.01423 | 0.007651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8304 | 1.270 | 0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.333 | -0.05890 | 0.05611 | -0.1836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2128 | 0.04378 | -0.4032 | 0.2695 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7985 | -0.3486 | -0.7543 | -0.7042 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7059 | -0.5388 | -0.1896 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 762.43981 | 1.000 | -0.9313 | -1.415 | -0.1729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2990 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1381 | -0.8850 | -0.7228 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5542 | -0.6633 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43981 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43981</span> | 97.00 | 0.05581 | 0.01423 | 0.007651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.028 | -0.03404 | 0.06496 | -0.1681 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1065 | 0.1184 | -0.4168 | 0.2498 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9058 | -0.3159 | -0.7884 | -1.255 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4119 | -0.8796 | -0.1400 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 762.43962 | 0.9999 | -0.9313 | -1.415 | -0.1729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2990 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1380 | -0.8850 | -0.7226 | -1.070 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5542 | -0.6633 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43962 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43962</span> | 96.99 | 0.05581 | 0.01423 | 0.007651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -1.383 | -0.05944 | 0.05652 | -0.1827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2071 | 0.04458 | -0.4356 | 0.2597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6953 | -0.3158 | -0.7477 | -0.7025 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6996 | -0.5341 | -0.1909 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 762.43950 | 1.000 | -0.9313 | -1.415 | -0.1729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.9131 | -0.2989 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1380 | -0.8850 | -0.7226 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5541 | -0.6632 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4395 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4395</span> | 97.00 | 0.05581 | 0.01423 | 0.007651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 2.549 | -0.06132 | 0.05688 | -0.1819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1843 | 0.05521 | -0.4401 | 0.2903 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8733 | -0.3487 | -0.7274 | -0.6827 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7019 | -0.6971 | -0.1749 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 762.43927 | 0.9999 | -0.9313 | -1.415 | -0.1728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9019 | -0.9131 | -0.2989 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1379 | -0.8849 | -0.7225 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5540 | -0.6632 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43927 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43927</span> | 96.99 | 0.05581 | 0.01423 | 0.007652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7672 | 0.8305 | 1.270 | 0.9381 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3204 | -0.03231 | 0.06473 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1091 | 0.1080 | -0.5711 | 0.1928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9793 | -0.3347 | -0.7909 | -0.6262 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4835 | -0.5228 | -0.1576 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 762.43906 | 0.9999 | -0.9313 | -1.415 | -0.1728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9019 | -0.9131 | -0.2988 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1378 | -0.8849 | -0.7224 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5540 | -0.6631 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43906 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7673 | 0.8306 | 1.270 | 0.9382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43906</span> | 96.99 | 0.05581 | 0.01423 | 0.007652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7673 | 0.8306 | 1.270 | 0.9382 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5587 | -0.06228 | 0.03863 | -0.1950 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1923 | 0.02120 | -0.5716 | 0.1497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.063 | -0.3909 | -0.8335 | -0.6812 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5632 | -0.5998 | -0.1754 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 762.43877 | 1.000 | -0.9313 | -1.415 | -0.1728 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9019 | -0.9131 | -0.2987 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1376 | -0.8848 | -0.7222 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5539 | -0.6630 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43877 | 97.01 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7673 | 0.8306 | 1.271 | 0.9383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43877</span> | 97.01 | 0.05581 | 0.01423 | 0.007652 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1224 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7673 | 0.8306 | 1.271 | 0.9383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.291 | -0.03430 | 0.06450 | -0.1679 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07426 | 0.1162 | -0.3841 | 0.3404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7902 | -0.2891 | -0.7321 | -1.195 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4125 | -0.8681 | -0.1491 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 762.43824 | 0.9999 | -0.9312 | -1.415 | -0.1727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9019 | -0.9131 | -0.2986 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1375 | -0.8848 | -0.7220 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5537 | -0.6629 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43824 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7674 | 0.8307 | 1.271 | 0.9384 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43824</span> | 96.99 | 0.05581 | 0.01423 | 0.007653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1223 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7674 | 0.8307 | 1.271 | 0.9384 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.2143 | -0.03008 | 0.06460 | -0.1683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09063 | 0.09635 | -0.3662 | 0.3094 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8321 | -0.3196 | -0.7371 | -1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3971 | -0.8686 | -0.1637 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 762.43774 | 0.9999 | -0.9312 | -1.415 | -0.1727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9019 | -0.9132 | -0.2986 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1373 | -0.8847 | -0.7219 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5537 | -0.6628 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43774 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7674 | 0.8307 | 1.271 | 0.9387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.621 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43774</span> | 96.99 | 0.05581 | 0.01423 | 0.007653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1149 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7674 | 0.8307 | 1.271 | 0.9387 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.621 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.093 | -0.02921 | 0.06344 | -0.1689 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09286 | 0.08671 | -0.5952 | 0.1702 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9595 | -0.3554 | -0.7565 | -1.200 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4954 | -0.5121 | -0.1787 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 762.43688 | 1.000 | -0.9312 | -1.415 | -0.1726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1370 | -0.8845 | -0.7215 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5534 | -0.6626 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43688 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.970 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43688</span> | 97.00 | 0.05581 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.631 | -0.02940 | 0.06277 | -0.1685 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07102 | 0.08313 | -0.3454 | 0.3850 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6531 | -0.2578 | -0.6895 | -0.5122 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3743 | -0.8283 | -0.1580 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 762.43834 | 0.9996 | -0.9312 | -1.415 | -0.1725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2981 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1367 | -0.8844 | -0.7212 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5532 | -0.6623 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43834 | 96.96 | -2.886 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43834</span> | 96.96 | 0.05582 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 762.43689 | 0.9998 | -0.9312 | -1.415 | -0.1726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1369 | -0.8845 | -0.7215 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5534 | -0.6625 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43689 | 96.98 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43689</span> | 96.98 | 0.05581 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 762.43680 | 0.9999 | -0.9312 | -1.415 | -0.1726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1369 | -0.8845 | -0.7215 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5534 | -0.6625 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4368 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4368</span> | 96.99 | 0.05581 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -1.290 | -0.05938 | 0.05401 | -0.1835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1692 | 0.01048 | -0.3277 | 0.2904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7941 | -0.3134 | -0.6583 | -0.6001 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6796 | -0.4935 | -0.1985 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 762.43669 | 1.000 | -0.9312 | -1.415 | -0.1726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1369 | -0.8845 | -0.7215 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5534 | -0.6625 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43669 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43669</span> | 97.00 | 0.05581 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.7530 | -0.06037 | 0.05419 | -0.1831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1576 | 0.01628 | -0.3476 | 0.2756 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7793 | -0.2989 | -0.6525 | -0.5921 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6883 | -0.6531 | -0.1740 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 762.43657 | 0.9999 | -0.9312 | -1.415 | -0.1726 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1369 | -0.8845 | -0.7214 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5533 | -0.6625 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43657 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43657</span> | 96.99 | 0.05581 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7675 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.6017 | -0.05955 | 0.05380 | -0.1836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1610 | 0.01132 | -0.3419 | 0.2571 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5470 | -0.3329 | -0.6445 | -0.5910 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6872 | -0.4903 | -0.2027 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 762.43648 | 1.000 | -0.9312 | -1.415 | -0.1725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2983 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1368 | -0.8845 | -0.7214 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5533 | -0.6625 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43648 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43648</span> | 97.00 | 0.05582 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8309 | 1.271 | 0.9393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.6240 | -0.06006 | 0.05383 | -0.1835 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1526 | 0.01440 | -0.3766 | 0.2889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6299 | -0.2748 | -0.6469 | -0.5850 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6758 | -0.4890 | -0.2032 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 762.43640 | 0.9999 | -0.9312 | -1.415 | -0.1725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2982 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1368 | -0.8845 | -0.7214 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5533 | -0.6624 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4364 | 96.99 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8309 | 1.271 | 0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4364</span> | 96.99 | 0.05582 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8309 | 1.271 | 0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.6134 | -0.05930 | 0.05345 | -0.1840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1552 | 0.009772 | -0.3787 | 0.2674 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7680 | -0.3180 | -0.6329 | -0.5960 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6746 | -0.4920 | -0.1810 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 762.43627 | 1.000 | -0.9312 | -1.415 | -0.1725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2982 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1367 | -0.8844 | -0.7213 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5532 | -0.6624 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43627 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.109 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43627</span> | 97.00 | 0.05582 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.109 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 762.43603 | 1.000 | -0.9312 | -1.415 | -0.1725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9018 | -0.9132 | -0.2982 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1367 | -0.8844 | -0.7213 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5532 | -0.6624 | -0.7685 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43603 | 97.00 | -2.886 | -4.252 | -4.873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43603</span> | 97.00 | 0.05582 | 0.01423 | 0.007654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.677 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7676 | 0.8310 | 1.272 | 0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 762.43566 | 1.000 | -0.9311 | -1.415 | -0.1724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | -0.9132 | -0.2979 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1365 | -0.8844 | -0.7210 | -1.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5529 | -0.6622 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43566 | 97.00 | -2.886 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7677 | 0.8310 | 1.272 | 0.9398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.622 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43566</span> | 97.00 | 0.05582 | 0.01424 | 0.007655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7677 | 0.8310 | 1.272 | 0.9398 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.622 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.185 | -0.02630 | 0.06197 | -0.1690 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04569 | 0.06766 | -0.1965 | 0.3760 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8361 | -0.3368 | -0.6862 | -1.092 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4397 | -0.4588 | -0.1669 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 762.43438 | 1.000 | -0.9309 | -1.415 | -0.1720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | -0.9133 | -0.2975 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1356 | -0.8841 | -0.7203 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5523 | -0.6619 | -0.7688 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43438 | 97.00 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9407 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43438</span> | 97.00 | 0.05583 | 0.01424 | 0.007658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9407 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.044 | -0.02148 | 0.06186 | -0.1669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02022 | 0.04124 | -0.2960 | 0.3008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7013 | -0.2777 | -0.6002 | -0.9685 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3508 | -0.7933 | -0.1801 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 762.45137 | 0.9988 | -0.9307 | -1.414 | -0.1714 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9015 | -0.9135 | -0.2962 | -0.4154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1345 | -0.8836 | -0.7191 | -1.066 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5512 | -0.6609 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.45137 | 96.89 | -2.885 | -4.251 | -4.871 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.040 | -1.971 | 2.679 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7682 | 0.8316 | 1.274 | 0.9425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.624 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.45137</span> | 96.89 | 0.05584 | 0.01425 | 0.007663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.679 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7682 | 0.8316 | 1.274 | 0.9425 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.624 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 762.43671 | 0.9995 | -0.9309 | -1.415 | -0.1720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | -0.9133 | -0.2974 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1355 | -0.8840 | -0.7202 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5523 | -0.6617 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43671 | 96.95 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43671</span> | 96.95 | 0.05583 | 0.01424 | 0.007658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 762.43423 | 0.9999 | -0.9309 | -1.415 | -0.1720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | -0.9133 | -0.2975 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1356 | -0.8841 | -0.7202 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5523 | -0.6618 | -0.7688 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43423 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9408 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43423</span> | 96.99 | 0.05583 | 0.01424 | 0.007658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9408 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5170 | -0.01948 | 0.06121 | -0.1679 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03590 | 0.02978 | -0.3666 | 0.2413 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7570 | -0.2885 | -0.6014 | -0.3882 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3403 | -0.8088 | -0.1895 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 762.43413 | 0.9999 | -0.9309 | -1.415 | -0.1720 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | -0.9133 | -0.2974 | -0.4155 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1356 | -0.8840 | -0.7202 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5523 | -0.6618 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43413 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9408 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43413</span> | 96.99 | 0.05583 | 0.01424 | 0.007658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8732 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9408 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.1909 | -0.05140 | 0.05299 | -0.1819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1179 | -0.03105 | -0.2940 | 0.3229 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7019 | -0.3052 | -0.5670 | -0.4669 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5306 | -0.6218 | -0.1957 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 762.43390 | 0.9999 | -0.9309 | -1.415 | -0.1719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2974 | -0.4156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1354 | -0.8840 | -0.7201 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5522 | -0.6617 | -0.7687 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4339 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4339</span> | 96.99 | 0.05583 | 0.01424 | 0.007659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7679 | 0.8313 | 1.273 | 0.9409 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.114 | -0.06011 | 0.02465 | -0.2051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1552 | -0.09095 | -0.5672 | 0.02114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8958 | -0.3459 | -0.7191 | -0.5113 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5884 | -0.9931 | -0.1777 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 762.43345 | 0.9998 | -0.9309 | -1.415 | -0.1719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2973 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1352 | -0.8839 | -0.7199 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5520 | -0.6614 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43345 | 96.98 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8314 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.110 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43345</span> | 96.98 | 0.05583 | 0.01424 | 0.007659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8314 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.199 | -0.01754 | 0.05950 | -0.1696 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02539 | 0.02275 | -0.4402 | 0.1842 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6341 | -0.3071 | -0.5996 | -0.4400 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3790 | -0.4298 | -0.1917 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 762.44283 | 1.001 | -0.9309 | -1.415 | -0.1718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2971 | -0.4158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1349 | -0.8837 | -0.7196 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5519 | -0.6613 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.44283 | 97.07 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.679 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7681 | 0.8315 | 1.273 | 0.9413 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.44283</span> | 97.07 | 0.05583 | 0.01424 | 0.007660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.679 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7681 | 0.8315 | 1.273 | 0.9413 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 762.43327 | 0.9999 | -0.9309 | -1.415 | -0.1719 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2972 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1352 | -0.8839 | -0.7199 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5520 | -0.6614 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43327 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8314 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43327</span> | 96.99 | 0.05583 | 0.01424 | 0.007659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8314 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.8515 | -0.01931 | 0.05976 | -0.1688 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01220 | 0.03131 | -0.3546 | 0.1731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7860 | -0.3212 | -0.6045 | -0.3881 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4306 | -0.4501 | -0.2053 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 762.43323 | 0.9999 | -0.9309 | -1.415 | -0.1718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2972 | -0.4157 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1351 | -0.8838 | -0.7198 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5520 | -0.6614 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43323 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43323</span> | 96.99 | 0.05583 | 0.01424 | 0.007659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9411 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -1.674 | -0.04944 | 0.05118 | -0.1837 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1087 | -0.03856 | -0.2663 | 0.2605 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5380 | -0.2892 | -0.5353 | -0.4315 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5100 | -0.4392 | -0.2141 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 762.43310 | 0.9999 | -0.9309 | -1.415 | -0.1718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2972 | -0.4158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1351 | -0.8838 | -0.7198 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5519 | -0.6614 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.4331 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.4331</span> | 96.99 | 0.05583 | 0.01424 | 0.007660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.5279 | -0.05046 | 0.05140 | -0.1826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09758 | -0.03208 | -0.2630 | 0.2539 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6786 | -0.2981 | -0.5397 | -0.4304 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4336 | -0.5936 | -0.1903 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 762.43324 | 0.9999 | -0.9309 | -1.415 | -0.1718 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9016 | -0.9133 | -0.2972 | -0.4158 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1351 | -0.8838 | -0.7198 | -1.067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5519 | -0.6614 | -0.7686 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | U| 762.43324 | 96.99 | -2.885 | -4.252 | -4.872 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.041 | -1.971 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.111 | 1.623 | 1.478 |...........|</span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 762.43324</span> | 96.99 | 0.05583 | 0.01424 | 0.007660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1150 | 0.1223 | 2.678 | 0.8731 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7680 | 0.8315 | 1.273 | 0.9412 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.111 | 1.623 | 1.478 |...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>last objective function was not at minimum, possible problems in optimization</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>using R matrix to calculate covariance, can check sandwich or S matrix with $covRS and $covS</span> +<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>gradient problems with initial estimate and covariance; see $scaleInfo</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/nobs.mkinfit.html b/docs/reference/nobs.mkinfit.html index 6b9948c3..0fc1ca7c 100644 --- a/docs/reference/nobs.mkinfit.html +++ b/docs/reference/nobs.mkinfit.html @@ -1,67 +1,12 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, 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class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Number of observations on which an mkinfit object was fitted</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nobs.mkinfit.R'><code>R/nobs.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nobs.mkinfit.R" class="external-link"><code>R/nobs.mkinfit.R</code></a></small> <div class="hidden name"><code>nobs.mkinfit.Rd</code></div> </div> @@ -147,51 +86,44 @@ <p>Number of observations on which an mkinfit object was fitted</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/stats/nobs.html'>nobs</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An mkinfit object</p></td> - </tr> - <tr> - <th>...</th> - <td><p>For compatibility with the generic method</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/stats/nobs.html" class="external-link">nobs</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An mkinfit object</p></dd> +<dt>...</dt> +<dd><p>For compatibility with the generic method</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The number of rows in the data included in the mkinfit object</p> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/parms.html b/docs/reference/parms.html index b4346b13..00726a1d 100644 --- 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content="This function always returns degradation model parameters as well as error model parameters, in order to avoid working with a fitted model without -considering the error structure that was assumed for the fit." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +considering the error structure that was assumed for the fit."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" 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label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ considering the error structure that was assumed for the fit." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ considering the error structure that was assumed for the fit." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,34 +60,27 @@ considering the error structure that was assumed for the fit." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Extract model parameters from mkinfit models</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/parms.mkinfit.R'><code>R/parms.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parms.mkinfit.R" class="external-link"><code>R/parms.mkinfit.R</code></a></small> <div class="hidden name"><code>parms.Rd</code></div> </div> @@ -151,148 +90,147 @@ model parameters, in order to avoid working with a fitted model without considering the error structure that was assumed for the fit.</p> </div> - <pre class="usage"><span class='fu'>parms</span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for mkinfit</span> -<span class='fu'>parms</span><span class='op'>(</span><span class='va'>object</span>, transformed <span class='op'>=</span> <span class='cn'>FALSE</span>, <span class='va'>...</span><span class='op'>)</span> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> -<span class='co'># S3 method for mmkin</span> -<span class='fu'>parms</span><span class='op'>(</span><span class='va'>object</span>, transformed <span class='op'>=</span> <span class='cn'>FALSE</span>, <span class='va'>...</span><span class='op'>)</span></pre> +<span class="co"># S3 method for mkinfit</span> +<span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A fitted model object. Methods are implemented for -<code><a href='mkinfit.html'>mkinfit()</a></code> objects and for <code><a href='mmkin.html'>mmkin()</a></code> objects.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used</p></td> - </tr> - <tr> - <th>transformed</th> - <td><p>Should the parameters be returned -as used internally during the optimisation?</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> +<span class="co"># S3 method for mmkin</span> +<span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A fitted model object. Methods are implemented for +<code><a href="mkinfit.html">mkinfit()</a></code> objects and for <code><a href="mmkin.html">mmkin()</a></code> objects.</p></dd> +<dt>...</dt> +<dd><p>Not used</p></dd> +<dt>transformed</dt> +<dd><p>Should the parameters be returned +as used internally during the optimisation?</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>For mkinfit objects, a numeric vector of fitted model parameters. For mmkin row objects, a matrix with the parameters with a row for each dataset. If the mmkin object has more than one row, a list of such matrices is returned.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># mkinfit objects</span> -<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'>parms</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 k_parent sigma -#> 82.4921598 0.3060633 4.6730124 </div><div class='input'><span class='fu'>parms</span><span class='op'>(</span><span class='va'>fit</span>, transformed <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 log_k_parent sigma -#> 82.492160 -1.183963 4.673012 </div><div class='input'> -<span class='co'># mmkin objects</span> -<span class='va'>ds</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>]</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span><span class='op'>)</span><span class='op'>]</span><span class='op'>)</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"Dataset"</span>, <span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>)</span> -<span class='co'># \dontrun{</span> -<span class='va'>fits</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"FOMC"</span>, <span class='st'>"DFOP"</span><span class='op'>)</span>, <span class='va'>ds</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -<span class='fu'>parms</span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span><span class='st'>"SFO"</span>, <span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450 -#> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421 -#> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673</div><div class='input'><span class='fu'>parms</span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span>, <span class='fl'>2</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='output co'>#> $SFO -#> Dataset 7 -#> parent_0 82.666781678 -#> k_parent 0.009647805 -#> sigma 7.040168584 -#> -#> $FOMC -#> Dataset 7 -#> parent_0 92.6837649 -#> alpha 0.4967832 -#> beta 14.1451255 -#> sigma 1.9167519 -#> -#> $DFOP -#> Dataset 7 -#> parent_0 91.058971589 -#> k1 0.044946770 -#> k2 0.002868336 -#> g 0.526942415 -#> sigma 2.221302196 -#> </div><div class='input'><span class='fu'>parms</span><span class='op'>(</span><span class='va'>fits</span><span class='op'>)</span> -</div><div class='output co'>#> $SFO -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450 -#> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421 -#> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673 -#> -#> $FOMC -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 95.558575 92.6837649 90.719787 98.383939 94.8481459 -#> alpha 1.338667 0.4967832 1.639099 1.074460 0.2805272 -#> beta 13.033315 14.1451255 5.007077 4.397126 6.9052224 -#> sigma 1.847671 1.9167519 1.066063 3.146056 1.6222778 -#> -#> $DFOP -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 96.55213663 91.058971589 90.34509493 98.14858820 94.311323734 -#> k1 0.21954588 0.044946770 0.41232288 0.31697588 0.080663857 -#> k2 0.02957934 0.002868336 0.07581766 0.03260384 0.003425417 -#> g 0.44845068 0.526942415 0.66091967 0.65322767 0.342652880 -#> sigma 1.35690468 2.221302196 1.34169076 2.87159846 1.942067831 -#> </div><div class='input'><span class='fu'>parms</span><span class='op'>(</span><span class='va'>fits</span>, transformed <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> $SFO -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 88.522754 82.666782 86.854731 91.777931 82.148094 -#> log_k_parent -2.848234 -4.641025 -1.559232 -2.093737 -4.933090 -#> sigma 5.152745 7.040169 3.676964 6.466923 6.504577 -#> -#> $FOMC -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 95.5585751 92.6837649 90.7197870 98.38393897 94.848146 -#> log_alpha 0.2916741 -0.6996015 0.4941466 0.07181816 -1.271085 -#> log_beta 2.5675088 2.6493701 1.6108523 1.48095106 1.932278 -#> sigma 1.8476712 1.9167519 1.0660627 3.14605557 1.622278 -#> -#> $DFOP -#> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10 -#> parent_0 96.5521366 91.0589716 90.3450949 98.1485882 94.3113237 -#> log_k1 -1.5161940 -3.1022764 -0.8859486 -1.1489296 -2.5174647 -#> log_k2 -3.5206791 -5.8540232 -2.5794240 -3.4233253 -5.6765322 -#> g_qlogis -0.2069326 0.1078741 0.6673953 0.6332573 -0.6514943 -#> sigma 1.3569047 2.2213022 1.3416908 2.8715985 1.9420678 -#> </div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># mkinfit objects</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma </span> +<span class="r-out co"><span class="r-pr">#></span> 82.4921598 0.3060633 4.6730124 </span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fit</span>, transformed <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent sigma </span> +<span class="r-out co"><span class="r-pr">#></span> 82.492160 -1.183963 4.673012 </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># mmkin objects</span></span> +<span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673</span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">[</span>, <span class="fl">2</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 82.666781678</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.009647805</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 7.040168584</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 92.6837649</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 0.4967832</span> +<span class="r-out co"><span class="r-pr">#></span> beta 14.1451255</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.9167519</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 91.058971589</span> +<span class="r-out co"><span class="r-pr">#></span> k1 0.044946770</span> +<span class="r-out co"><span class="r-pr">#></span> k2 0.002868336</span> +<span class="r-out co"><span class="r-pr">#></span> g 0.526942415</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.221302196</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 95.558575 92.6837649 90.719787 98.383939 94.8481459</span> +<span class="r-out co"><span class="r-pr">#></span> alpha 1.338667 0.4967832 1.639099 1.074460 0.2805272</span> +<span class="r-out co"><span class="r-pr">#></span> beta 13.033315 14.1451255 5.007077 4.397126 6.9052224</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.847671 1.9167519 1.066063 3.146056 1.6222778</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.55213663 91.058971589 90.34509493 98.14858820 94.311323734</span> +<span class="r-out co"><span class="r-pr">#></span> k1 0.21954588 0.044946770 0.41232288 0.31697588 0.080663857</span> +<span class="r-out co"><span class="r-pr">#></span> k2 0.02957934 0.002868336 0.07581766 0.03260384 0.003425417</span> +<span class="r-out co"><span class="r-pr">#></span> g 0.44845068 0.526942415 0.66091967 0.65322767 0.342652880</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.35690468 2.221302196 1.34169076 2.87159846 1.942067831</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span>, transformed <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $SFO</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 88.522754 82.666782 86.854731 91.777931 82.148094</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.848234 -4.641025 -1.559232 -2.093737 -4.933090</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.152745 7.040169 3.676964 6.466923 6.504577</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 95.5585751 92.6837649 90.7197870 98.38393897 94.848146</span> +<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.2916741 -0.6996015 0.4941466 0.07181816 -1.271085</span> +<span class="r-out co"><span class="r-pr">#></span> log_beta 2.5675088 2.6493701 1.6108523 1.48095106 1.932278</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.8476712 1.9167519 1.0660627 3.14605557 1.622278</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> +<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 96.5521366 91.0589716 90.3450949 98.1485882 94.3113237</span> +<span class="r-out co"><span class="r-pr">#></span> log_k1 -1.5161940 -3.1022764 -0.8859486 -1.1489296 -2.5174647</span> +<span class="r-out co"><span class="r-pr">#></span> log_k2 -3.5206791 -5.8540232 -2.5794240 -3.4233253 -5.6765322</span> +<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.2069326 0.1078741 0.6673953 0.6332573 -0.6514943</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.3569047 2.2213022 1.3416908 2.8715985 1.9420678</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + 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data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/plot.mixed.mmkin.R'><code>R/plot.mixed.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mixed.mmkin.R" class="external-link"><code>R/plot.mixed.mmkin.R</code></a></small> <div class="hidden name"><code>plot.mixed.mmkin.Rd</code></div> </div> @@ -147,167 +86,158 @@ <p>Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object</p> </div> - <pre class="usage"><span class='co'># S3 method for mixed.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span> - <span class='va'>x</span>, - i <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fu'><a href='https://rdrr.io/r/base/nrow.html'>ncol</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>mmkin</span><span class='op'>)</span>, - obs_vars <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>mkinmod</span><span class='op'>$</span><span class='va'>map</span><span class='op'>)</span>, - standardized <span class='op'>=</span> <span class='cn'>TRUE</span>, - xlab <span class='op'>=</span> <span class='st'>"Time"</span>, - xlim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/range.html'>range</a></span><span class='op'>(</span><span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>$</span><span class='va'>time</span><span class='op'>)</span>, - resplot <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"predicted"</span>, <span class='st'>"time"</span><span class='op'>)</span>, - pred_over <span class='op'>=</span> <span class='cn'>NULL</span>, - ymax <span class='op'>=</span> <span class='st'>"auto"</span>, - maxabs <span class='op'>=</span> <span class='st'>"auto"</span>, - ncol.legend <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/ifelse.html'>ifelse</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'><=</span> <span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'>+</span> <span class='fl'>1</span>, <span class='fu'><a href='https://rdrr.io/r/base/ifelse.html'>ifelse</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'><=</span> <span class='fl'>8</span>, <span class='fl'>3</span>, <span class='fl'>4</span><span class='op'>)</span><span class='op'>)</span>, - nrow.legend <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Round.html'>ceiling</a></span><span class='op'>(</span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span> <span class='op'>+</span> <span class='fl'>1</span><span class='op'>)</span><span class='op'>/</span><span class='va'>ncol.legend</span><span class='op'>)</span>, - rel.height.legend <span class='op'>=</span> <span class='fl'>0.02</span> <span class='op'>+</span> <span class='fl'>0.07</span> <span class='op'>*</span> <span class='va'>nrow.legend</span>, - rel.height.bottom <span class='op'>=</span> <span class='fl'>1.1</span>, - pch_ds <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>i</span><span class='op'>)</span>, - col_ds <span class='op'>=</span> <span class='va'>pch_ds</span> <span class='op'>+</span> <span class='fl'>1</span>, - lty_ds <span class='op'>=</span> <span class='va'>col_ds</span>, - frame <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mixed.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span> + <span class="va">x</span>, + i <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/nrow.html" class="external-link">ncol</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">mmkin</span><span class="op">)</span>, + obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>, + standardized <span class="op">=</span> <span class="cn">TRUE</span>, + xlab <span class="op">=</span> <span class="st">"Time"</span>, + xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/range.html" class="external-link">range</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span>, + resplot <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"predicted"</span>, <span class="st">"time"</span><span class="op">)</span>, + pred_over <span class="op">=</span> <span class="cn">NULL</span>, + test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>, + conf.level <span class="op">=</span> <span class="fl">0.6</span>, + ymax <span class="op">=</span> <span class="st">"auto"</span>, + maxabs <span class="op">=</span> <span class="st">"auto"</span>, + ncol.legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op"><=</span> <span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">+</span> <span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op"><=</span> <span class="fl">8</span>, <span class="fl">3</span>, <span class="fl">4</span><span class="op">)</span><span class="op">)</span>, + nrow.legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">ceiling</a></span><span class="op">(</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">+</span> <span class="fl">1</span><span class="op">)</span><span class="op">/</span><span class="va">ncol.legend</span><span class="op">)</span>, + rel.height.legend <span class="op">=</span> <span class="fl">0.02</span> <span class="op">+</span> <span class="fl">0.07</span> <span class="op">*</span> <span class="va">nrow.legend</span>, + rel.height.bottom <span class="op">=</span> <span class="fl">1.1</span>, + pch_ds <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span>, + col_ds <span class="op">=</span> <span class="va">pch_ds</span> <span class="op">+</span> <span class="fl">1</span>, + lty_ds <span class="op">=</span> <span class="va">col_ds</span>, + frame <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An object of class <a href='mixed.html'>mixed.mmkin</a>, <a href='nlme.mmkin.html'>nlme.mmkin</a></p></td> - </tr> - <tr> - <th>i</th> - <td><p>A numeric index to select datasets for which to plot the individual predictions, -in case plots get too large</p></td> - </tr> - <tr> - <th>obs_vars</th> - <td><p>A character vector of names of the observed variables for + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An object of class <a href="mixed.html">mixed.mmkin</a>, <a href="saem.html">saem.mmkin</a> or <a href="nlme.mmkin.html">nlme.mmkin</a></p></dd> +<dt>i</dt> +<dd><p>A numeric index to select datasets for which to plot the individual predictions, +in case plots get too large</p></dd> +<dt>obs_vars</dt> +<dd><p>A character vector of names of the observed variables for which the data and the model should be plotted. Defauls to all observed -variables in the model.</p></td> - </tr> - <tr> - <th>standardized</th> - <td><p>Should the residuals be standardized? Only takes effect if -<code>resplot = "time"</code>.</p></td> - </tr> - <tr> - <th>xlab</th> - <td><p>Label for the x axis.</p></td> - </tr> - <tr> - <th>xlim</th> - <td><p>Plot range in x direction.</p></td> - </tr> - <tr> - <th>resplot</th> - <td><p>Should the residuals plotted against time or against -predicted values?</p></td> - </tr> - <tr> - <th>pred_over</th> - <td><p>Named list of alternative predictions as obtained -from <a href='mkinpredict.html'>mkinpredict</a> with a compatible <a href='mkinmod.html'>mkinmod</a>.</p></td> - </tr> - <tr> - <th>ymax</th> - <td><p>Vector of maximum y axis values</p></td> - </tr> - <tr> - <th>maxabs</th> - <td><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></td> - </tr> - <tr> - <th>ncol.legend</th> - <td><p>Number of columns to use in the legend</p></td> - </tr> - <tr> - <th>nrow.legend</th> - <td><p>Number of rows to use in the legend</p></td> - </tr> - <tr> - <th>rel.height.legend</th> - <td><p>The relative height of the legend shown on top</p></td> - </tr> - <tr> - <th>rel.height.bottom</th> - <td><p>The relative height of the bottom plot row</p></td> - </tr> - <tr> - <th>pch_ds</th> - <td><p>Symbols to be used for plotting the data.</p></td> - </tr> - <tr> - <th>col_ds</th> - <td><p>Colors used for plotting the observed data and the -corresponding model prediction lines for the different datasets.</p></td> - </tr> - <tr> - <th>lty_ds</th> - <td><p>Line types to be used for the model predictions.</p></td> - </tr> - <tr> - <th>frame</th> - <td><p>Should a frame be drawn around the plots?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to <code><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +variables in the model.</p></dd> +<dt>standardized</dt> +<dd><p>Should the residuals be standardized? Only takes effect if +<code>resplot = "time"</code>.</p></dd> +<dt>xlab</dt> +<dd><p>Label for the x axis.</p></dd> +<dt>xlim</dt> +<dd><p>Plot range in x direction.</p></dd> +<dt>resplot</dt> +<dd><p>Should the residuals plotted against time or against +predicted values?</p></dd> +<dt>pred_over</dt> +<dd><p>Named list of alternative predictions as obtained +from <a href="mkinpredict.html">mkinpredict</a> with a compatible <a href="mkinmod.html">mkinmod</a>.</p></dd> +<dt>test_log_parms</dt> +<dd><p>Passed to <a href="mean_degparms.html">mean_degparms</a> in the case of an +<a href="mixed.html">mixed.mmkin</a> object</p></dd> +<dt>conf.level</dt> +<dd><p>Passed to <a href="mean_degparms.html">mean_degparms</a> in the case of an +<a href="mixed.html">mixed.mmkin</a> object</p></dd> +<dt>ymax</dt> +<dd><p>Vector of maximum y axis values</p></dd> +<dt>maxabs</dt> +<dd><p>Maximum absolute value of the residuals. This is used for the +scaling of the y axis and defaults to "auto".</p></dd> +<dt>ncol.legend</dt> +<dd><p>Number of columns to use in the legend</p></dd> +<dt>nrow.legend</dt> +<dd><p>Number of rows to use in the legend</p></dd> +<dt>rel.height.legend</dt> +<dd><p>The relative height of the legend shown on top</p></dd> +<dt>rel.height.bottom</dt> +<dd><p>The relative height of the bottom plot row</p></dd> +<dt>pch_ds</dt> +<dd><p>Symbols to be used for plotting the data.</p></dd> +<dt>col_ds</dt> +<dd><p>Colors used for plotting the observed data and the +corresponding model prediction lines for the different datasets.</p></dd> +<dt>lty_ds</dt> +<dd><p>Line types to be used for the model predictions.</p></dd> +<dt>frame</dt> +<dd><p>Should a frame be drawn around the plots?</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>ds</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>experimental_data_for_UBA_2019</span><span class='op'>[</span><span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>]</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>x</span><span class='op'>)</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>data</span><span class='op'>[</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span><span class='op'>)</span><span class='op'>]</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='st'>"ds "</span>, <span class='fl'>6</span><span class='op'>:</span><span class='fl'>10</span><span class='op'>)</span> -<span class='va'>dfop_sfo</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='st'>"A1"</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='co'># \dontrun{</span> -<span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"DFOP-SFO"</span> <span class='op'>=</span> <span class='va'>dfop_sfo</span><span class='op'>)</span>, <span class='va'>ds</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>[</span>, <span class='fl'>3</span><span class='op'>:</span><span class='fl'>4</span><span class='op'>]</span>, standardized <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mixed.mmkin-1.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># For this fit we need to increase pnlsMaxiter, and we increase the</span> -<span class='co'># tolerance in order to speed up the fit for this example evaluation</span> -<span class='va'>f_nlme</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f</span>, control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>pnlsMaxIter <span class='op'>=</span> <span class='fl'>120</span>, tolerance <span class='op'>=</span> <span class='fl'>1e-3</span><span class='op'>)</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>f_nlme</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mixed.mmkin-2.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"ds "</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="fl">3</span><span class="op">:</span><span class="fl">4</span><span class="op">]</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mixed.mmkin-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># For this fit we need to increase pnlsMaxiter, and we increase the</span></span> +<span class="r-in"><span class="co"># tolerance in order to speed up the fit for this example evaluation</span></span> +<span class="r-in"><span class="co"># It still takes 20 seconds to run</span></span> +<span class="r-in"><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span>, control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">1e-3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mixed.mmkin-2.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_saem</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in saem(f, transformations = "saemix"):</span> unused argument (transformations = "saemix")</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in plot(f_saem):</span> object 'f_saem' not found</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_obs</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_nlmix</span> <span class="op"><-</span> <span class="fu">nlmix</span><span class="op">(</span><span class="va">f_obs</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in nlmix(f_obs):</span> could not find function "nlmix"</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmix</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in plot(f_nlmix):</span> object 'f_nlmix' not found</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># We can overlay the two variants if we generate predictions</span></span> +<span class="r-in"><span class="va">pred_nlme</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> +<span class="r-in"> <span class="va">f_nlme</span><span class="op">$</span><span class="va">bparms.optim</span><span class="op">[</span><span class="op">-</span><span class="fl">1</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="va">f_nlme</span><span class="op">$</span><span class="va">bparms.optim</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, A1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">180</span>, by <span class="op">=</span> <span class="fl">0.2</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem</span>, pred_over <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>nlme <span class="op">=</span> <span class="va">pred_nlme</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in plot(f_saem, pred_over = list(nlme = pred_nlme)):</span> object 'f_saem' not found</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/plot.mkinfit-1.png b/docs/reference/plot.mkinfit-1.png Binary files differindex 54e5c46f..ea1032fb 100644 --- a/docs/reference/plot.mkinfit-1.png +++ 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template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -74,13 +19,12 @@ observed data together with the solution of the fitted model." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -89,8 +33,7 @@ observed data together with the solution of the fitted model." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -100,6 +43,9 @@ observed data together with the solution of the fitted model." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -114,279 +60,231 @@ observed data together with the solution of the fitted model." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Plot the observed data and the fitted model of an mkinfit object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/plot.mkinfit.R'><code>R/plot.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mkinfit.R" class="external-link"><code>R/plot.mkinfit.R</code></a></small> <div class="hidden name"><code>plot.mkinfit.Rd</code></div> </div> <div class="ref-description"> <p>Solves the differential equations with the optimised and fixed parameters -from a previous successful call to <code><a href='mkinfit.html'>mkinfit</a></code> and plots the +from a previous successful call to <code><a href="mkinfit.html">mkinfit</a></code> and plots the observed data together with the solution of the fitted model.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span> - <span class='va'>x</span>, - fit <span class='op'>=</span> <span class='va'>x</span>, - obs_vars <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>mkinmod</span><span class='op'>$</span><span class='va'>map</span><span class='op'>)</span>, - xlab <span class='op'>=</span> <span class='st'>"Time"</span>, - ylab <span class='op'>=</span> <span class='st'>"Residue"</span>, - xlim <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/range.html'>range</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>data</span><span class='op'>$</span><span class='va'>time</span><span class='op'>)</span>, - ylim <span class='op'>=</span> <span class='st'>"default"</span>, - col_obs <span class='op'>=</span> <span class='fl'>1</span><span class='op'>:</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>obs_vars</span><span class='op'>)</span>, - pch_obs <span class='op'>=</span> <span class='va'>col_obs</span>, - lty_obs <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/rep.html'>rep</a></span><span class='op'>(</span><span class='fl'>1</span>, <span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='va'>obs_vars</span><span class='op'>)</span><span class='op'>)</span>, - add <span class='op'>=</span> <span class='cn'>FALSE</span>, - legend <span class='op'>=</span> <span class='op'>!</span><span class='va'>add</span>, - show_residuals <span class='op'>=</span> <span class='cn'>FALSE</span>, - show_errplot <span class='op'>=</span> <span class='cn'>FALSE</span>, - maxabs <span class='op'>=</span> <span class='st'>"auto"</span>, - sep_obs <span class='op'>=</span> <span class='cn'>FALSE</span>, - rel.height.middle <span class='op'>=</span> <span class='fl'>0.9</span>, - row_layout <span class='op'>=</span> <span class='cn'>FALSE</span>, - lpos <span class='op'>=</span> <span class='st'>"topright"</span>, - inset <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0.05</span>, <span class='fl'>0.05</span><span class='op'>)</span>, - show_errmin <span class='op'>=</span> <span class='cn'>FALSE</span>, - errmin_digits <span class='op'>=</span> <span class='fl'>3</span>, - frame <span class='op'>=</span> <span class='cn'>TRUE</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='fu'>plot_sep</span><span class='op'>(</span> - <span class='va'>fit</span>, - show_errmin <span class='op'>=</span> <span class='cn'>TRUE</span>, - show_residuals <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/ifelse.html'>ifelse</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/identical.html'>identical</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>err_mod</span>, <span class='st'>"const"</span><span class='op'>)</span>, <span class='cn'>TRUE</span>, <span class='st'>"standardized"</span><span class='op'>)</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='fu'>plot_res</span><span class='op'>(</span> - <span class='va'>fit</span>, - sep_obs <span class='op'>=</span> <span class='cn'>FALSE</span>, - show_errmin <span class='op'>=</span> <span class='va'>sep_obs</span>, - standardized <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/ifelse.html'>ifelse</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/identical.html'>identical</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>err_mod</span>, <span class='st'>"const"</span><span class='op'>)</span>, <span class='cn'>FALSE</span>, <span class='cn'>TRUE</span><span class='op'>)</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='fu'>plot_err</span><span class='op'>(</span><span class='va'>fit</span>, sep_obs <span class='op'>=</span> <span class='cn'>FALSE</span>, show_errmin <span class='op'>=</span> <span class='va'>sep_obs</span>, <span class='va'>...</span><span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span> + <span class="va">x</span>, + fit <span class="op">=</span> <span class="va">x</span>, + obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>, + xlab <span class="op">=</span> <span class="st">"Time"</span>, + ylab <span class="op">=</span> <span class="st">"Residue"</span>, + xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/range.html" class="external-link">range</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span>, + ylim <span class="op">=</span> <span class="st">"default"</span>, + col_obs <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">obs_vars</span><span class="op">)</span>, + pch_obs <span class="op">=</span> <span class="va">col_obs</span>, + lty_obs <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">obs_vars</span><span class="op">)</span><span class="op">)</span>, + add <span class="op">=</span> <span class="cn">FALSE</span>, + legend <span class="op">=</span> <span class="op">!</span><span class="va">add</span>, + show_residuals <span class="op">=</span> <span class="cn">FALSE</span>, + show_errplot <span class="op">=</span> <span class="cn">FALSE</span>, + maxabs <span class="op">=</span> <span class="st">"auto"</span>, + sep_obs <span class="op">=</span> <span class="cn">FALSE</span>, + rel.height.middle <span class="op">=</span> <span class="fl">0.9</span>, + row_layout <span class="op">=</span> <span class="cn">FALSE</span>, + lpos <span class="op">=</span> <span class="st">"topright"</span>, + inset <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.05</span>, <span class="fl">0.05</span><span class="op">)</span>, + show_errmin <span class="op">=</span> <span class="cn">FALSE</span>, + errmin_digits <span class="op">=</span> <span class="fl">3</span>, + frame <span class="op">=</span> <span class="cn">TRUE</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="fu">plot_sep</span><span class="op">(</span> + <span class="va">fit</span>, + show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, + show_residuals <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">err_mod</span>, <span class="st">"const"</span><span class="op">)</span>, <span class="cn">TRUE</span>, <span class="st">"standardized"</span><span class="op">)</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="fu">plot_res</span><span class="op">(</span> + <span class="va">fit</span>, + sep_obs <span class="op">=</span> <span class="cn">FALSE</span>, + show_errmin <span class="op">=</span> <span class="va">sep_obs</span>, + standardized <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">err_mod</span>, <span class="st">"const"</span><span class="op">)</span>, <span class="cn">FALSE</span>, <span class="cn">TRUE</span><span class="op">)</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="fu">plot_err</span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">FALSE</span>, show_errmin <span class="op">=</span> <span class="va">sep_obs</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>Alias for fit introduced for compatibility with the generic S3 -method.</p></td> - </tr> - <tr> - <th>fit</th> - <td><p>An object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>obs_vars</th> - <td><p>A character vector of names of the observed variables for + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>Alias for fit introduced for compatibility with the generic S3 +method.</p></dd> +<dt>fit</dt> +<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>obs_vars</dt> +<dd><p>A character vector of names of the observed variables for which the data and the model should be plotted. Defauls to all observed -variables in the model.</p></td> - </tr> - <tr> - <th>xlab</th> - <td><p>Label for the x axis.</p></td> - </tr> - <tr> - <th>ylab</th> - <td><p>Label for the y axis.</p></td> - </tr> - <tr> - <th>xlim</th> - <td><p>Plot range in x direction.</p></td> - </tr> - <tr> - <th>ylim</th> - <td><p>Plot range in y direction.</p></td> - </tr> - <tr> - <th>col_obs</th> - <td><p>Colors used for plotting the observed data and the -corresponding model prediction lines.</p></td> - </tr> - <tr> - <th>pch_obs</th> - <td><p>Symbols to be used for plotting the data.</p></td> - </tr> - <tr> - <th>lty_obs</th> - <td><p>Line types to be used for the model predictions.</p></td> - </tr> - <tr> - <th>add</th> - <td><p>Should the plot be added to an existing plot?</p></td> - </tr> - <tr> - <th>legend</th> - <td><p>Should a legend be added to the plot?</p></td> - </tr> - <tr> - <th>show_residuals</th> - <td><p>Should residuals be shown? If only one plot of the +variables in the model.</p></dd> +<dt>xlab</dt> +<dd><p>Label for the x axis.</p></dd> +<dt>ylab</dt> +<dd><p>Label for the y axis.</p></dd> +<dt>xlim</dt> +<dd><p>Plot range in x direction.</p></dd> +<dt>ylim</dt> +<dd><p>Plot range in y direction.</p></dd> +<dt>col_obs</dt> +<dd><p>Colors used for plotting the observed data and the +corresponding model prediction lines.</p></dd> +<dt>pch_obs</dt> +<dd><p>Symbols to be used for plotting the data.</p></dd> +<dt>lty_obs</dt> +<dd><p>Line types to be used for the model predictions.</p></dd> +<dt>add</dt> +<dd><p>Should the plot be added to an existing plot?</p></dd> +<dt>legend</dt> +<dd><p>Should a legend be added to the plot?</p></dd> +<dt>show_residuals</dt> +<dd><p>Should residuals be shown? If only one plot of the fits is shown, the residual plot is in the lower third of the plot. Otherwise, i.e. if "sep_obs" is given, the residual plots will be located to the right of the plots of the fitted curves. If this is set to 'standardized', a plot of the residuals divided by the standard deviation -given by the fitted error model will be shown.</p></td> - </tr> - <tr> - <th>show_errplot</th> - <td><p>Should squared residuals and the error model be shown? +given by the fitted error model will be shown.</p></dd> +<dt>show_errplot</dt> +<dd><p>Should squared residuals and the error model be shown? If only one plot of the fits is shown, this plot is in the lower third of the plot. Otherwise, i.e. if "sep_obs" is given, the residual plots will -be located to the right of the plots of the fitted curves.</p></td> - </tr> - <tr> - <th>maxabs</th> - <td><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></td> - </tr> - <tr> - <th>sep_obs</th> - <td><p>Should the observed variables be shown in separate subplots? +be located to the right of the plots of the fitted curves.</p></dd> +<dt>maxabs</dt> +<dd><p>Maximum absolute value of the residuals. This is used for the +scaling of the y axis and defaults to "auto".</p></dd> +<dt>sep_obs</dt> +<dd><p>Should the observed variables be shown in separate subplots? If yes, residual plots requested by "show_residuals" will be shown next -to, not below the plot of the fits.</p></td> - </tr> - <tr> - <th>rel.height.middle</th> - <td><p>The relative height of the middle plot, if more -than two rows of plots are shown.</p></td> - </tr> - <tr> - <th>row_layout</th> - <td><p>Should we use a row layout where the residual plot or the -error model plot is shown to the right?</p></td> - </tr> - <tr> - <th>lpos</th> - <td><p>Position(s) of the legend(s). Passed to <code><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></code> as +to, not below the plot of the fits.</p></dd> +<dt>rel.height.middle</dt> +<dd><p>The relative height of the middle plot, if more +than two rows of plots are shown.</p></dd> +<dt>row_layout</dt> +<dd><p>Should we use a row layout where the residual plot or the +error model plot is shown to the right?</p></dd> +<dt>lpos</dt> +<dd><p>Position(s) of the legend(s). Passed to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code> as the first argument. If not length one, this should be of the same length -as the obs_var argument.</p></td> - </tr> - <tr> - <th>inset</th> - <td><p>Passed to <code><a href='https://rdrr.io/r/graphics/legend.html'>legend</a></code> if applicable.</p></td> - </tr> - <tr> - <th>show_errmin</th> - <td><p>Should the FOCUS chi2 error value be shown in the upper -margin of the plot?</p></td> - </tr> - <tr> - <th>errmin_digits</th> - <td><p>The number of significant digits for rounding the FOCUS -chi2 error percentage.</p></td> - </tr> - <tr> - <th>frame</th> - <td><p>Should a frame be drawn around the plots?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to <code><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></code>.</p></td> - </tr> - <tr> - <th>standardized</th> - <td><p>When calling 'plot_res', should the residuals be -standardized in the residual plot?</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +as the obs_var argument.</p></dd> +<dt>inset</dt> +<dd><p>Passed to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code> if applicable.</p></dd> +<dt>show_errmin</dt> +<dd><p>Should the FOCUS chi2 error value be shown in the upper +margin of the plot?</p></dd> +<dt>errmin_digits</dt> +<dd><p>The number of significant digits for rounding the FOCUS +chi2 error percentage.</p></dd> +<dt>frame</dt> +<dd><p>Should a frame be drawn around the plots?</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> +<dt>standardized</dt> +<dd><p>When calling 'plot_res', should the residuals be +standardized in the residual plot?</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - - <p>If the current plot device is a <code><a href='https://rdrr.io/pkg/tikzDevice/man/tikz.html'>tikz</a></code> device, then + </div> + <div id="details"> + <h2>Details</h2> + <p>If the current plot device is a <code><a href="https://rdrr.io/pkg/tikzDevice/man/tikz.html" class="external-link">tikz</a></code> device, then latex is being used for the formatting of the chi2 error level, if <code>show_errmin = TRUE</code>.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># One parent compound, one metabolite, both single first order, path from</span> -<span class='co'># parent to sink included</span> -<span class='co'># \dontrun{</span> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"m1"</span>, full <span class='op'>=</span> <span class='st'>"Parent"</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, full <span class='op'>=</span> <span class='st'>"Metabolite M1"</span> <span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'><span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_2006_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>plot_res</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-2.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>plot_res</span><span class='op'>(</span><span class='va'>fit</span>, standardized <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-3.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'>plot_err</span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-4.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># Show the observed variables separately, with residuals</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fit</span>, sep_obs <span class='op'>=</span> <span class='cn'>TRUE</span>, show_residuals <span class='op'>=</span> <span class='cn'>TRUE</span>, lpos <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"topright"</span>, <span class='st'>"bottomright"</span><span class='op'>)</span>, - show_errmin <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-5.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># The same can be obtained with less typing, using the convenience function plot_sep</span> -<span class='fu'>plot_sep</span><span class='op'>(</span><span class='va'>fit</span>, lpos <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"topright"</span>, <span class='st'>"bottomright"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-6.png' alt='' width='700' height='433' /></div><div class='input'> -<span class='co'># Show the observed variables separately, with the error model</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fit</span>, sep_obs <span class='op'>=</span> <span class='cn'>TRUE</span>, show_errplot <span class='op'>=</span> <span class='cn'>TRUE</span>, lpos <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"topright"</span>, <span class='st'>"bottomright"</span><span class='op'>)</span>, - show_errmin <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mkinfit-7.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># One parent compound, one metabolite, both single first order, path from</span></span> +<span class="r-in"><span class="co"># parent to sink included</span></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span>, full <span class="op">=</span> <span class="st">"Parent"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, full <span class="op">=</span> <span class="st">"Metabolite M1"</span> <span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">plot_res</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">plot_res</span><span class="op">(</span><span class="va">fit</span>, standardized <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-3.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu">plot_err</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-4.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Show the observed variables separately, with residuals</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span>,</span> +<span class="r-in"> show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-5.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The same can be obtained with less typing, using the convenience function plot_sep</span></span> +<span class="r-in"><span class="fu">plot_sep</span><span class="op">(</span><span class="va">fit</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-6.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Show the observed variables separately, with the error model</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_errplot <span class="op">=</span> <span class="cn">TRUE</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span>,</span> +<span class="r-in"> show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mkinfit-7.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/plot.mmkin-1.png b/docs/reference/plot.mmkin-1.png Binary files differindex d06d683c..235e33a7 100644 --- a/docs/reference/plot.mmkin-1.png +++ b/docs/reference/plot.mmkin-1.png diff --git a/docs/reference/plot.mmkin-2.png b/docs/reference/plot.mmkin-2.png Binary files differindex d3678aca..7af84edf 100644 --- a/docs/reference/plot.mmkin-2.png +++ b/docs/reference/plot.mmkin-2.png diff --git a/docs/reference/plot.mmkin-3.png b/docs/reference/plot.mmkin-3.png Binary files differindex f84d5782..56bfac50 100644 --- a/docs/reference/plot.mmkin-3.png +++ 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When it is a column, -the fit of at least one model to the same dataset is shown." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +the fit of at least one model to the same dataset is shown."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ the fit of at least one model to the same dataset is shown." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ the fit of at least one model to the same dataset is shown." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ the fit of at least one model to the same dataset is shown." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,186 +62,158 @@ the fit of at least one model to the same dataset is shown." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Plot model fits (observed and fitted) and the residuals for a row or column of an mmkin object</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/plot.mmkin.R'><code>R/plot.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mmkin.R" class="external-link"><code>R/plot.mmkin.R</code></a></small> <div class="hidden name"><code>plot.mmkin.Rd</code></div> </div> <div class="ref-description"> - <p>When x is a row selected from an mmkin object (<code><a href='[.mmkin.html'>[.mmkin</a></code>), the + <p>When x is a row selected from an mmkin object (<code><a href="Extract.mmkin.html">[.mmkin</a></code>), the same model fitted for at least one dataset is shown. When it is a column, the fit of at least one model to the same dataset is shown.</p> </div> - <pre class="usage"><span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span> - <span class='va'>x</span>, - main <span class='op'>=</span> <span class='st'>"auto"</span>, - legends <span class='op'>=</span> <span class='fl'>1</span>, - resplot <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"time"</span>, <span class='st'>"errmod"</span><span class='op'>)</span>, - ylab <span class='op'>=</span> <span class='st'>"Residue"</span>, - standardized <span class='op'>=</span> <span class='cn'>FALSE</span>, - show_errmin <span class='op'>=</span> <span class='cn'>TRUE</span>, - errmin_var <span class='op'>=</span> <span class='st'>"All data"</span>, - errmin_digits <span class='op'>=</span> <span class='fl'>3</span>, - cex <span class='op'>=</span> <span class='fl'>0.7</span>, - rel.height.middle <span class='op'>=</span> <span class='fl'>0.9</span>, - ymax <span class='op'>=</span> <span class='st'>"auto"</span>, - <span class='va'>...</span> -<span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An object of class <code><a href='mmkin.html'>mmkin</a></code>, with either one row or one -column.</p></td> - </tr> - <tr> - <th>main</th> - <td><p>The main title placed on the outer margin of the plot.</p></td> - </tr> - <tr> - <th>legends</th> - <td><p>An index for the fits for which legends should be shown.</p></td> - </tr> - <tr> - <th>resplot</th> - <td><p>Should the residuals plotted against time, using -<code><a href='mkinresplot.html'>mkinresplot</a></code>, or as squared residuals against predicted -values, with the error model, using <code><a href='mkinerrplot.html'>mkinerrplot</a></code>.</p></td> - </tr> - <tr> - <th>ylab</th> - <td><p>Label for the y axis.</p></td> - </tr> - <tr> - <th>standardized</th> - <td><p>Should the residuals be standardized? This option -is passed to <code><a href='mkinresplot.html'>mkinresplot</a></code>, it only takes effect if -<code>resplot = "time"</code>.</p></td> - </tr> - <tr> - <th>show_errmin</th> - <td><p>Should the chi2 error level be shown on top of the plots -to the left?</p></td> - </tr> - <tr> - <th>errmin_var</th> - <td><p>The variable for which the FOCUS chi2 error value should -be shown.</p></td> - </tr> - <tr> - <th>errmin_digits</th> - <td><p>The number of significant digits for rounding the FOCUS -chi2 error percentage.</p></td> - </tr> - <tr> - <th>cex</th> - <td><p>Passed to the plot functions and <code><a href='https://rdrr.io/r/graphics/mtext.html'>mtext</a></code>.</p></td> - </tr> - <tr> - <th>rel.height.middle</th> - <td><p>The relative height of the middle plot, if more -than two rows of plots are shown.</p></td> - </tr> - <tr> - <th>ymax</th> - <td><p>Maximum y axis value for <code><a href='plot.mkinfit.html'>plot.mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to <code><a href='plot.mkinfit.html'>plot.mkinfit</a></code> and -<code><a href='mkinresplot.html'>mkinresplot</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span> + <span class="va">x</span>, + main <span class="op">=</span> <span class="st">"auto"</span>, + legends <span class="op">=</span> <span class="fl">1</span>, + resplot <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"time"</span>, <span class="st">"errmod"</span><span class="op">)</span>, + ylab <span class="op">=</span> <span class="st">"Residue"</span>, + standardized <span class="op">=</span> <span class="cn">FALSE</span>, + show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, + errmin_var <span class="op">=</span> <span class="st">"All data"</span>, + errmin_digits <span class="op">=</span> <span class="fl">3</span>, + cex <span class="op">=</span> <span class="fl">0.7</span>, + rel.height.middle <span class="op">=</span> <span class="fl">0.9</span>, + ymax <span class="op">=</span> <span class="st">"auto"</span>, + <span class="va">...</span> +<span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An object of class <code><a href="mmkin.html">mmkin</a></code>, with either one row or one +column.</p></dd> +<dt>main</dt> +<dd><p>The main title placed on the outer margin of the plot.</p></dd> +<dt>legends</dt> +<dd><p>An index for the fits for which legends should be shown.</p></dd> +<dt>resplot</dt> +<dd><p>Should the residuals plotted against time, using +<code><a href="mkinresplot.html">mkinresplot</a></code>, or as squared residuals against predicted +values, with the error model, using <code><a href="mkinerrplot.html">mkinerrplot</a></code>.</p></dd> +<dt>ylab</dt> +<dd><p>Label for the y axis.</p></dd> +<dt>standardized</dt> +<dd><p>Should the residuals be standardized? This option +is passed to <code><a href="mkinresplot.html">mkinresplot</a></code>, it only takes effect if +<code>resplot = "time"</code>.</p></dd> +<dt>show_errmin</dt> +<dd><p>Should the chi2 error level be shown on top of the plots +to the left?</p></dd> +<dt>errmin_var</dt> +<dd><p>The variable for which the FOCUS chi2 error value should +be shown.</p></dd> +<dt>errmin_digits</dt> +<dd><p>The number of significant digits for rounding the FOCUS +chi2 error percentage.</p></dd> +<dt>cex</dt> +<dd><p>Passed to the plot functions and <code><a href="https://rdrr.io/r/graphics/mtext.html" class="external-link">mtext</a></code>.</p></dd> +<dt>rel.height.middle</dt> +<dd><p>The relative height of the middle plot, if more +than two rows of plots are shown.</p></dd> +<dt>ymax</dt> +<dd><p>Maximum y axis value for <code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> and +<code><a href="mkinresplot.html">mkinresplot</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - - <p>If the current plot device is a <code><a href='https://rdrr.io/pkg/tikzDevice/man/tikz.html'>tikz</a></code> device, then + </div> + <div id="details"> + <h2>Details</h2> + <p>If the current plot device is a <code><a href="https://rdrr.io/pkg/tikzDevice/man/tikz.html" class="external-link">tikz</a></code> device, then latex is being used for the formatting of the chi2 error level.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='co'># \dontrun{</span> - <span class='co'># Only use one core not to offend CRAN checks</span> - <span class='va'>fits</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"FOMC"</span>, <span class='st'>"HS"</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span><span class='st'>"FOCUS B"</span> <span class='op'>=</span> <span class='va'>FOCUS_2006_B</span>, <span class='st'>"FOCUS C"</span> <span class='op'>=</span> <span class='va'>FOCUS_2006_C</span><span class='op'>)</span>, <span class='co'># named list for titles</span> - cores <span class='op'>=</span> <span class='fl'>1</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Optimisation did not converge:</span> -#> <span class='warning'>iteration limit reached without convergence (10)</span></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span>, <span class='st'>"FOCUS C"</span><span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mmkin-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span><span class='st'>"FOMC"</span>, <span class='op'>]</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mmkin-2.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span><span class='st'>"FOMC"</span>, <span class='op'>]</span>, show_errmin <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mmkin-3.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='co'># We can also plot a single fit, if we like the way plot.mmkin works, but then the plot</span> - <span class='co'># height should be smaller than the plot width (this is not possible for the html pages</span> - <span class='co'># generated by pkgdown, as far as I know).</span> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span><span class='st'>"FOMC"</span>, <span class='st'>"FOCUS C"</span><span class='op'>]</span><span class='op'>)</span> <span class='co'># same as plot(fits[1, 2])</span> -</div><div class='img'><img src='plot.mmkin-4.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='co'># Show the error models</span> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fits</span><span class='op'>[</span><span class='st'>"FOMC"</span>, <span class='op'>]</span>, resplot <span class='op'>=</span> <span class='st'>"errmod"</span><span class='op'>)</span> -</div><div class='img'><img src='plot.mmkin-5.png' alt='' width='700' height='433' /></div><div class='input'> <span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="co"># Only use one core not to offend CRAN checks</span></span> +<span class="r-in"> <span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"HS"</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS B"</span> <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>, <span class="co"># named list for titles</span></span> +<span class="r-in"> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mmkin-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mmkin-2.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, show_errmin <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mmkin-3.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># We can also plot a single fit, if we like the way plot.mmkin works, but then the plot</span></span> +<span class="r-in"> <span class="co"># height should be smaller than the plot width (this is not possible for the html pages</span></span> +<span class="r-in"> <span class="co"># generated by pkgdown, as far as I know).</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span> <span class="co"># same as plot(fits[1, 2])</span></span> +<span class="r-plt img"><img src="plot.mmkin-4.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># Show the error models</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, resplot <span class="op">=</span> <span class="st">"errmod"</span><span class="op">)</span></span> +<span class="r-plt img"><img src="plot.mmkin-5.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/plot.nafta.html b/docs/reference/plot.nafta.html index 544ee5eb..d3407a24 100644 --- a/docs/reference/plot.nafta.html +++ b/docs/reference/plot.nafta.html @@ -1,68 +1,13 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - 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- +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -73,13 +18,12 @@ function (SFO, then IORE, then DFOP)." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ function (SFO, then IORE, then DFOP)." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ function (SFO, then IORE, then DFOP)." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ function (SFO, then IORE, then DFOP)." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Plot the results of the three models used in the NAFTA scheme.</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/nafta.R'><code>R/nafta.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nafta.R" class="external-link"><code>R/nafta.R</code></a></small> <div class="hidden name"><code>plot.nafta.Rd</code></div> </div> @@ -149,65 +88,56 @@ function (SFO, then IORE, then DFOP)." /> function (SFO, then IORE, then DFOP).</p> </div> - <pre class="usage"><span class='co'># S3 method for nafta</span> -<span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>x</span>, legend <span class='op'>=</span> <span class='cn'>FALSE</span>, main <span class='op'>=</span> <span class='st'>"auto"</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An object of class <code><a href='nafta.html'>nafta</a></code>.</p></td> - </tr> - <tr> - <th>legend</th> - <td><p>Should a legend be added?</p></td> - </tr> - <tr> - <th>main</th> - <td><p>Possibility to override the main title of the plot.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Further arguments passed to <code><a href='plot.mmkin.html'>plot.mmkin</a></code>.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for nafta</span> +<span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">x</span>, legend <span class="op">=</span> <span class="cn">FALSE</span>, main <span class="op">=</span> <span class="st">"auto"</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>x</dt> +<dd><p>An object of class <code><a href="nafta.html">nafta</a></code>.</p></dd> +<dt>legend</dt> +<dd><p>Should a legend be added?</p></dd> +<dt>main</dt> +<dd><p>Possibility to override the main title of the plot.</p></dd> +<dt>...</dt> +<dd><p>Further arguments passed to <code><a href="plot.mmkin.html">plot.mmkin</a></code>.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The function is called for its side effect.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - - <p>Calls <code><a href='plot.mmkin.html'>plot.mmkin</a></code>.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - + </div> + <div id="details"> + <h2>Details</h2> + <p>Calls <code><a href="plot.mmkin.html">plot.mmkin</a></code>.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - 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Follow the links +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Objects exported from other packages — reexports • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Objects exported from other packages — reexports"><meta property="og:description" content="These objects are imported from other packages. Follow the links below to see their documentation. - lmtestlrtest - - nlmenlme + lmtest +lrtest -" /> + nlme +intervals, nlme + nlmixr +nlmixr -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> -<!--[if lt IE 9]> +"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -79,13 +32,12 @@ below to see their documentation. </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.5</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -94,8 +46,7 @@ below to see their documentation. <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -105,6 +56,9 @@ below to see their documentation. <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -119,76 +73,70 @@ below to see their documentation. <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Objects exported from other packages</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/lrtest.mkinfit.R'><code>R/lrtest.mkinfit.R</code></a>, <a href='https://github.com/jranke/mkin/blob/master/R/nlme.mmkin.R'><code>R/nlme.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/intervals.R" class="external-link"><code>R/intervals.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/lrtest.mkinfit.R" class="external-link"><code>R/lrtest.mkinfit.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.mmkin.R" class="external-link"><code>R/nlme.mmkin.R</code></a>, and 1 more</small> <div class="hidden name"><code>reexports.Rd</code></div> </div> <div class="ref-description"> <p>These objects are imported from other packages. Follow the links below to see their documentation.</p> -<dl> - <dt>lmtest</dt><dd><p><code><a href='https://rdrr.io/pkg/lmtest/man/lrtest.html'>lrtest</a></code></p></dd> +<dl><dt>lmtest</dt> +<dd><p><code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></code></p></dd> - <dt>nlme</dt><dd><p><code><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></code></p></dd> -</dl> - </div> + <dt>nlme</dt> +<dd><p><code><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></code>, <code><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></code></p></dd> + + + <dt>nlmixr</dt> +<dd><p><code><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></code></p></dd> +</dl></div> + </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/residuals.mkinfit.html b/docs/reference/residuals.mkinfit.html index c5c2dcaf..19e077c5 100644 --- a/docs/reference/residuals.mkinfit.html +++ b/docs/reference/residuals.mkinfit.html @@ -1,67 +1,12 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" 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role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -72,13 +17,12 @@ </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -87,8 +31,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -98,6 +41,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -112,34 +58,27 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Extract residuals from an mkinfit model</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/residuals.mkinfit.R'><code>R/residuals.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/residuals.mkinfit.R" class="external-link"><code>R/residuals.mkinfit.R</code></a></small> <div class="hidden name"><code>residuals.mkinfit.Rd</code></div> </div> @@ -147,60 +86,54 @@ <p>Extract residuals from an mkinfit model</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/stats/residuals.html'>residuals</a></span><span class='op'>(</span><span class='va'>object</span>, standardized <span class='op'>=</span> <span class='cn'>FALSE</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>A <code><a href='mkinfit.html'>mkinfit</a></code> object</p></td> - </tr> - <tr> - <th>standardized</th> - <td><p>Should the residuals be standardized by dividing by the -standard deviation obtained from the fitted error model?</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used</p></td> - </tr> - </table> - - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>f</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"DFOP"</span>, <span class='va'>FOCUS_2006_C</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/stats/residuals.html'>residuals</a></span><span class='op'>(</span><span class='va'>f</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.09726374 -0.13912142 -0.15351210 0.73388322 -0.08657004 -0.93204702 -#> [7] -0.03269080 1.45347823 -0.88423697</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/stats/residuals.html'>residuals</a></span><span class='op'>(</span><span class='va'>f</span>, standardized <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> [1] 0.13969917 -0.19981904 -0.22048826 1.05407091 -0.12433989 -1.33869208 -#> [7] -0.04695355 2.08761977 -1.27002287</div></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">object</span>, standardized <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>A <code><a href="mkinfit.html">mkinfit</a></code> object</p></dd> +<dt>standardized</dt> +<dd><p>Should the residuals be standardized by dividing by the +standard deviation obtained from the fitted error model?</p></dd> +<dt>...</dt> +<dd><p>Not used</p></dd> +</dl></div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.09726374 -0.13912142 -0.15351210 0.73388322 -0.08657004 -0.93204702</span> +<span class="r-out co"><span class="r-pr">#></span> [7] -0.03269080 1.45347823 -0.88423697</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">f</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.13969917 -0.19981904 -0.22048826 1.05407091 -0.12433989 -1.33869208</span> +<span class="r-out co"><span class="r-pr">#></span> [7] -0.04695355 2.08761977 -1.27002287</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/saem.html b/docs/reference/saem.html new file mode 100644 index 00000000..8b86b5a2 --- /dev/null +++ b/docs/reference/saem.html @@ -0,0 +1,327 @@ +<!DOCTYPE html> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Fit nonlinear mixed models with SAEM — saem • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" 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integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Fit nonlinear mixed models with SAEM — saem"><meta property="og:description" content="This function uses saemix::saemix() as a backend for fitting nonlinear mixed +effects models created from mmkin row objects using the Stochastic Approximation +Expectation Maximisation algorithm (SAEM)."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> +<script 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navbar-nav"><li> + <a href="../reference/index.html">Functions and data</a> +</li> +<li class="dropdown"> + <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + Articles + + <span class="caret"></span> + </a> + <ul class="dropdown-menu" role="menu"><li> + <a href="../articles/mkin.html">Introduction to mkin</a> + </li> + <li> + <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + </li> + <li> + <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Fit nonlinear mixed models with SAEM</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/saem.R" class="external-link"><code>R/saem.R</code></a></small> + <div class="hidden name"><code>saem.Rd</code></div> + </div> + + <div class="ref-description"> + <p>This function uses <code><a href="https://rdrr.io/pkg/saemix/man/saemix.html" class="external-link">saemix::saemix()</a></code> as a backend for fitting nonlinear mixed +effects models created from <a href="mmkin.html">mmkin</a> row objects using the Stochastic Approximation +Expectation Maximisation algorithm (SAEM).</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">saem</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for mmkin</span> +<span class="fu">saem</span><span class="op">(</span> + <span class="va">object</span>, + transformations <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"mkin"</span>, <span class="st">"saemix"</span><span class="op">)</span>, + degparms_start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>, + test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>, + conf.level <span class="op">=</span> <span class="fl">0.6</span>, + solution_type <span class="op">=</span> <span class="st">"auto"</span>, + nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">300</span>, <span class="fl">100</span><span class="op">)</span>, + control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>displayProgress <span class="op">=</span> <span class="cn">FALSE</span>, print <span class="op">=</span> <span class="cn">FALSE</span>, nbiter.saemix <span class="op">=</span> <span class="va">nbiter.saemix</span>, + save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>, + fail_with_errors <span class="op">=</span> <span class="cn">TRUE</span>, + verbose <span class="op">=</span> <span class="cn">FALSE</span>, + quiet <span class="op">=</span> <span class="cn">FALSE</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="co"># S3 method for saem.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span> + +<span class="fu">saemix_model</span><span class="op">(</span> + <span class="va">object</span>, + solution_type <span class="op">=</span> <span class="st">"auto"</span>, + transformations <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"mkin"</span>, <span class="st">"saemix"</span><span class="op">)</span>, + degparms_start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>, + test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>, + conf.level <span class="op">=</span> <span class="fl">0.6</span>, + verbose <span class="op">=</span> <span class="cn">FALSE</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="fu">saemix_data</span><span class="op">(</span><span class="va">object</span>, verbose <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An <a href="mmkin.html">mmkin</a> row object containing several fits of the same +<a href="mkinmod.html">mkinmod</a> model to different datasets</p></dd> +<dt>...</dt> +<dd><p>Further parameters passed to <a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel</a>.</p></dd> +<dt>transformations</dt> +<dd><p>Per default, all parameter transformations are done +in mkin. If this argument is set to 'saemix', parameter transformations +are done in 'saemix' for the supported cases. Currently this is only +supported in cases where the initial concentration of the parent is not fixed, +SFO or DFOP is used for the parent and there is either no metabolite or one.</p></dd> +<dt>degparms_start</dt> +<dd><p>Parameter values given as a named numeric vector will +be used to override the starting values obtained from the 'mmkin' object.</p></dd> +<dt>test_log_parms</dt> +<dd><p>If TRUE, an attempt is made to use more robust starting +values for population parameters fitted as log parameters in mkin (like +rate constants) by only considering rate constants that pass the t-test +when calculating mean degradation parameters using <a href="mean_degparms.html">mean_degparms</a>.</p></dd> +<dt>conf.level</dt> +<dd><p>Possibility to adjust the required confidence level +for parameter that are tested if requested by 'test_log_parms'.</p></dd> +<dt>solution_type</dt> +<dd><p>Possibility to specify the solution type in case the +automatic choice is not desired</p></dd> +<dt>nbiter.saemix</dt> +<dd><p>Convenience option to increase the number of +iterations</p></dd> +<dt>control</dt> +<dd><p>Passed to <a href="https://rdrr.io/pkg/saemix/man/saemix.html" class="external-link">saemix::saemix</a>.</p></dd> +<dt>fail_with_errors</dt> +<dd><p>Should a failure to compute standard errors +from the inverse of the Fisher Information Matrix be a failure?</p></dd> +<dt>verbose</dt> +<dd><p>Should we print information about created objects of +type <a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel</a> and <a href="https://rdrr.io/pkg/saemix/man/SaemixData-class.html" class="external-link">saemix::SaemixData</a>?</p></dd> +<dt>quiet</dt> +<dd><p>Should we suppress the messages saemix prints at the beginning +and the end of the optimisation process?</p></dd> +<dt>x</dt> +<dd><p>An saem.mmkin object to print</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>An S3 object of class 'saem.mmkin', containing the fitted +<a href="https://rdrr.io/pkg/saemix/man/SaemixObject-class.html" class="external-link">saemix::SaemixObject</a> as a list component named 'so'. The +object also inherits from 'mixed.mmkin'. +An <a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel</a> object. +An <a href="https://rdrr.io/pkg/saemix/man/SaemixData-class.html" class="external-link">saemix::SaemixData</a> object.</p> + </div> + <div id="details"> + <h2>Details</h2> + <p>An mmkin row object is essentially a list of mkinfit objects that have been +obtained by fitting the same model to a list of datasets using <a href="mkinfit.html">mkinfit</a>.</p> +<p>Starting values for the fixed effects (population mean parameters, argument +psi0 of <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code> are the mean values of the parameters found +using <a href="mmkin.html">mmkin</a>.</p> + </div> + <div id="see-also"> + <h2>See also</h2> + <div class="dont-index"><p><a href="summary.saem.mmkin.html">summary.saem.mmkin</a> <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a></p></div> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mmkin_parent_p0_fixed</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">ds</span>,</span> +<span class="r-in"> state.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, fixed_initials <span class="op">=</span> <span class="st">"parent"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_saem_p0_fixed</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent_p0_fixed</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_mmkin_parent</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_saem_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="va">f_saem_fomc</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="va">f_saem_dfop</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The returned saem.mmkin object contains an SaemixObject, therefore we can use</span></span> +<span class="r-in"><span class="co"># functions from saemix</span></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Loading required package: npde</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Attaching package: ‘npde’</span> +<span class="r-msg co"><span class="r-pr">#></span> The following object is masked from ‘package:nlmixr’:</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> warfarin</span> +<span class="r-msg co"><span class="r-pr">#></span> Package saemix, version 3.0</span> +<span class="r-msg co"><span class="r-pr">#></span> please direct bugs, questions and feedback to emmanuelle.comets@inserm.fr</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> Attaching package: ‘saemix’</span> +<span class="r-msg co"><span class="r-pr">#></span> The following objects are masked from ‘package:npde’:</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> kurtosis, skewness</span> +<span class="r-msg co"><span class="r-pr">#></span> The following object is masked from ‘package:RxODE’:</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> phi</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span><span class="va">f_saem_sfo</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_dfop</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in compare.saemix(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so):</span> object 'f_saem_sfo' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'plot': object 'f_saem_fomc' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"individual.fit"</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'plot': object 'f_saem_fomc' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"npde"</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'plot': object 'f_saem_fomc' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"vpc"</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'plot': object 'f_saem_fomc' not found</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">f_mmkin_parent_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_saem_fomc_tc</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_fomc_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in compare.saemix(f_saem_fomc$so, f_saem_fomc_tc$so):</span> object 'f_saem_fomc' not found</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">fomc_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"><span class="co"># The following fit uses analytical solutions for SFO-SFO and DFOP-SFO,</span></span> +<span class="r-in"><span class="co"># and compiled ODEs for FOMC that are much slower</span></span> +<span class="r-in"><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># saem fits of SFO-SFO and DFOP-SFO to these data take about five seconds</span></span> +<span class="r-in"><span class="co"># each on this system, as we use analytical solutions written for saemix.</span></span> +<span class="r-in"><span class="co"># When using the analytical solutions written for mkin this took around</span></span> +<span class="r-in"><span class="co"># four minutes</span></span> +<span class="r-in"><span class="va">f_saem_sfo_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="va">f_saem_dfop_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="co"># We can use print, plot and summary methods to check the results</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'print': object 'f_saem_dfop_sfo' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'x' in selecting a method for function 'plot': object 'f_saem_dfop_sfo' not found</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'object' in selecting a method for function 'summary': object 'f_saem_dfop_sfo' not found</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The following takes about 6 minutes</span></span> +<span class="r-in"><span class="co">#f_saem_dfop_sfo_deSolve <- saem(f_mmkin["DFOP-SFO", ], solution_type = "deSolve",</span></span> +<span class="r-in"><span class="co"># control = list(nbiter.saemix = c(200, 80), nbdisplay = 10))</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co">#saemix::compare.saemix(list(</span></span> +<span class="r-in"><span class="co"># f_saem_dfop_sfo$so,</span></span> +<span class="r-in"><span class="co"># f_saem_dfop_sfo_deSolve$so))</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># If the model supports it, we can also use eigenvalue based solutions, which</span></span> +<span class="r-in"><span class="co"># take a similar amount of time</span></span> +<span class="r-in"><span class="co">#f_saem_sfo_sfo_eigen <- saem(f_mmkin["SFO-SFO", ], solution_type = "eigen",</span></span> +<span class="r-in"><span class="co"># control = list(nbiter.saemix = c(200, 80), nbdisplay = 10))</span></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/schaefer07_complex_case-1.png b/docs/reference/schaefer07_complex_case-1.png Binary files differindex 96aab2dc..eee9e0cc 100644 --- a/docs/reference/schaefer07_complex_case-1.png +++ b/docs/reference/schaefer07_complex_case-1.png diff --git a/docs/reference/schaefer07_complex_case.html b/docs/reference/schaefer07_complex_case.html index 979e4c29..8c39ca1b 100644 --- a/docs/reference/schaefer07_complex_case.html +++ b/docs/reference/schaefer07_complex_case.html @@ -1,69 +1,14 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta 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results from the fitting are also included." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> + The results from the fitting are also included."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script 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-</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Metabolism data set used for checking the software quality of KinGUI</h1> @@ -151,93 +90,109 @@ The results from the fitting are also included.</p> </div> - <pre class="usage"><span class='va'>schaefer07_complex_case</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">schaefer07_complex_case</span></code></pre></div> + </div> + + <div id="format"> + <h2>Format</h2> + <p>The data set is a data frame with 8 observations on the following 6 variables.</p><dl><dt><code>time</code></dt> +<dd><p>a numeric vector</p></dd> + + <dt><code>parent</code></dt> +<dd><p>a numeric vector</p></dd> + + <dt><code>A1</code></dt> +<dd><p>a numeric vector</p></dd> + <dt><code>B1</code></dt> +<dd><p>a numeric vector</p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>C1</code></dt> +<dd><p>a numeric vector</p></dd> + + <dt><code>A2</code></dt> +<dd><p>a numeric vector</p></dd> - <p>The data set is a data frame with 8 observations on the following 6 variables.</p><dl> - <dt><code>time</code></dt><dd><p>a numeric vector</p></dd> - <dt><code>parent</code></dt><dd><p>a numeric vector</p></dd> - <dt><code>A1</code></dt><dd><p>a numeric vector</p></dd> - <dt><code>B1</code></dt><dd><p>a numeric vector</p></dd> - <dt><code>C1</code></dt><dd><p>a numeric vector</p></dd> - <dt><code>A2</code></dt><dd><p>a numeric vector</p></dd> </dl><p>The results are a data frame with 14 results for different parameter values</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>Schäfer D, Mikolasch B, Rainbird P and Harvey B (2007). KinGUI: a new kinetic software tool for evaluations according to FOCUS degradation kinetics. In: Del Re AAM, Capri E, Fragoulis G and Trevisan M (Eds.). Proceedings of the XIII Symposium Pesticide Chemistry, Piacenza, 2007, p. 916-923.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>data</span> <span class='op'><-</span> <span class='fu'><a href='mkin_wide_to_long.html'>mkin_wide_to_long</a></span><span class='op'>(</span><span class='va'>schaefer07_complex_case</span>, time <span class='op'>=</span> <span class='st'>"time"</span><span class='op'>)</span> -<span class='va'>model</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"A1"</span>, <span class='st'>"B1"</span>, <span class='st'>"C1"</span><span class='op'>)</span>, sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - A1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"A2"</span><span class='op'>)</span>, - B1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - C1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - A2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='co'># \dontrun{</span> - <span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>model</span>, <span class='va'>data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/graphics/plot.default.html'>plot</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='schaefer07_complex_case-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> $ff -#> parent_A1 parent_B1 parent_C1 parent_sink A1_A2 A1_sink -#> 0.3809620 0.1954667 0.4235713 0.0000000 0.4479619 0.5520381 -#> -#> $distimes -#> DT50 DT90 -#> parent 13.95078 46.34350 -#> A1 49.75342 165.27728 -#> B1 37.26908 123.80520 -#> C1 11.23131 37.30961 -#> A2 28.50624 94.69567 -#> </div><div class='input'> <span class='co'># }</span> - <span class='co'># Compare with the results obtained in the original publication</span> - <span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>schaefer07_complex_results</span><span class='op'>)</span> -</div><div class='output co'>#> compound parameter KinGUI ModelMaker deviation -#> 1 parent degradation rate 0.0496 0.0506 2.0 -#> 2 parent DT50 13.9900 13.6900 2.2 -#> 3 metabolite A1 formation fraction 0.3803 0.3696 2.9 -#> 4 metabolite A1 degradation rate 0.0139 0.0136 2.2 -#> 5 metabolite A1 DT50 49.9600 50.8900 1.8 -#> 6 metabolite B1 formation fraction 0.1866 0.1818 2.6 -#> 7 metabolite B1 degradation rate 0.0175 0.0172 1.7 -#> 8 metabolite B1 DT50 39.6100 40.2400 1.6 -#> 9 metabolite C1 formation fraction 0.4331 0.4486 3.5 -#> 10 metabolite C1 degradation rate 0.0638 0.0700 8.9 -#> 11 metabolite C1 DT50 10.8700 9.9000 9.8 -#> 12 metabolite A2 formation fraction 0.4529 0.4559 0.7 -#> 13 metabolite A2 degradation rate 0.0245 0.0244 0.4 -#> 14 metabolite A2 DT50 28.2400 28.4500 0.7</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">data</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">schaefer07_complex_case</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span> +<span class="r-in"><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"A1"</span>, <span class="st">"B1"</span>, <span class="st">"C1"</span><span class="op">)</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span> +<span class="r-in"> B1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> C1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> A2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/plot-SaemixObject-ANY-method.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="schaefer07_complex_case-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> $ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_A1 parent_B1 parent_C1 parent_sink A1_A2 A1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 0.3809620 0.1954667 0.4235713 0.0000000 0.4479619 0.5520381 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> $distimes</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 13.95078 46.34350</span> +<span class="r-out co"><span class="r-pr">#></span> A1 49.75342 165.27728</span> +<span class="r-out co"><span class="r-pr">#></span> B1 37.26908 123.80520</span> +<span class="r-out co"><span class="r-pr">#></span> C1 11.23131 37.30961</span> +<span class="r-out co"><span class="r-pr">#></span> A2 28.50624 94.69567</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-in"> <span class="co"># }</span></span> +<span class="r-in"> <span class="co"># Compare with the results obtained in the original publication</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">schaefer07_complex_results</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> compound parameter KinGUI ModelMaker deviation</span> +<span class="r-out co"><span class="r-pr">#></span> 1 parent degradation rate 0.0496 0.0506 2.0</span> +<span class="r-out co"><span class="r-pr">#></span> 2 parent DT50 13.9900 13.6900 2.2</span> +<span class="r-out co"><span class="r-pr">#></span> 3 metabolite A1 formation fraction 0.3803 0.3696 2.9</span> +<span class="r-out co"><span class="r-pr">#></span> 4 metabolite A1 degradation rate 0.0139 0.0136 2.2</span> +<span class="r-out co"><span class="r-pr">#></span> 5 metabolite A1 DT50 49.9600 50.8900 1.8</span> +<span class="r-out co"><span class="r-pr">#></span> 6 metabolite B1 formation fraction 0.1866 0.1818 2.6</span> +<span class="r-out co"><span class="r-pr">#></span> 7 metabolite B1 degradation rate 0.0175 0.0172 1.7</span> +<span class="r-out co"><span class="r-pr">#></span> 8 metabolite B1 DT50 39.6100 40.2400 1.6</span> +<span class="r-out co"><span class="r-pr">#></span> 9 metabolite C1 formation fraction 0.4331 0.4486 3.5</span> +<span class="r-out co"><span class="r-pr">#></span> 10 metabolite C1 degradation rate 0.0638 0.0700 8.9</span> +<span class="r-out co"><span class="r-pr">#></span> 11 metabolite C1 DT50 10.8700 9.9000 9.8</span> +<span class="r-out co"><span class="r-pr">#></span> 12 metabolite A2 formation fraction 0.4529 0.4559 0.7</span> +<span class="r-out co"><span class="r-pr">#></span> 13 metabolite A2 degradation rate 0.0245 0.0244 0.4</span> +<span class="r-out co"><span class="r-pr">#></span> 14 metabolite A2 DT50 28.2400 28.4500 0.7</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/sigma_twocomp-1.png b/docs/reference/sigma_twocomp-1.png Binary files differindex fddb86a7..0353b72c 100644 --- a/docs/reference/sigma_twocomp-1.png 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data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ dependence of the measured value \(y\):" /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ dependence of the measured value \(y\):" /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,34 +59,27 @@ dependence of the measured value \(y\):" /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Two-component error model</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/sigma_twocomp.R'><code>R/sigma_twocomp.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/sigma_twocomp.R" class="external-link"><code>R/sigma_twocomp.R</code></a></small> <div class="hidden name"><code>sigma_twocomp.Rd</code></div> </div> @@ -149,40 +88,36 @@ dependence of the measured value \(y\):" /> dependence of the measured value \(y\):</p> </div> - <pre class="usage"><span class='fu'>sigma_twocomp</span><span class='op'>(</span><span class='va'>y</span>, <span class='va'>sigma_low</span>, <span class='va'>rsd_high</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>y</th> - <td><p>The magnitude of the observed value</p></td> - </tr> - <tr> - <th>sigma_low</th> - <td><p>The asymptotic minimum of the standard deviation for low -observed values</p></td> - </tr> - <tr> - <th>rsd_high</th> - <td><p>The coefficient describing the increase of the standard -deviation with the magnitude of the observed value</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">sigma_twocomp</span><span class="op">(</span><span class="va">y</span>, <span class="va">sigma_low</span>, <span class="va">rsd_high</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>y</dt> +<dd><p>The magnitude of the observed value</p></dd> +<dt>sigma_low</dt> +<dd><p>The asymptotic minimum of the standard deviation for low +observed values</p></dd> +<dt>rsd_high</dt> +<dd><p>The coefficient describing the increase of the standard +deviation with the magnitude of the observed value</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The standard deviation of the response variable.</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>$$\sigma = \sqrt{ \sigma_{low}^2 + y^2 * {rsd}_{high}^2}$$ sigma = sqrt(sigma_low^2 + y^2 * rsd_high^2)</p> <p>This is the error model used for example by Werner et al. (1978). The model proposed by Rocke and Lorenzato (1995) can be written in this form as well, but assumes approximate lognormal distribution of errors for high values of y.</p> - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - + </div> + <div id="references"> + <h2>References</h2> <p>Werner, Mario, Brooks, Samuel H., and Knott, Lancaster B. (1978) Additive, Multiplicative, and Mixed Analytical Errors. Clinical Chemistry 24(11), 1895-1898.</p> @@ -190,61 +125,62 @@ Additive, Multiplicative, and Mixed Analytical Errors. Clinical Chemistry measurement error in analytical chemistry. Technometrics 37(2), 176-184.</p> <p>Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical Degradation Data. <em>Environments</em> 6(12) 124 -doi: <a href='https://doi.org/10.3390/environments6120124'>10.3390/environments6120124</a> +doi: <a href="https://doi.org/10.3390/environments6120124" class="external-link">10.3390/environments6120124</a> .</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='va'>times</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> -<span class='va'>d_pred</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/data.frame.html'>data.frame</a></span><span class='op'>(</span>time <span class='op'>=</span> <span class='va'>times</span>, parent <span class='op'>=</span> <span class='fl'>100</span> <span class='op'>*</span> <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>exp</a></span><span class='op'>(</span><span class='op'>-</span> <span class='fl'>0.03</span> <span class='op'>*</span> <span class='va'>times</span><span class='op'>)</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>123456</span><span class='op'>)</span> -<span class='va'>d_syn</span> <span class='op'><-</span> <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_pred</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>y</span><span class='op'>)</span> <span class='fu'>sigma_twocomp</span><span class='op'>(</span><span class='va'>y</span>, <span class='fl'>1</span>, <span class='fl'>0.07</span><span class='op'>)</span>, - reps <span class='op'>=</span> <span class='fl'>2</span>, n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span> -<span class='va'>f_nls</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/nls.html'>nls</a></span><span class='op'>(</span><span class='va'>value</span> <span class='op'>~</span> <span class='fu'><a href='https://rdrr.io/r/stats/SSasymp.html'>SSasymp</a></span><span class='op'>(</span><span class='va'>time</span>, <span class='fl'>0</span>, <span class='va'>parent_0</span>, <span class='va'>lrc</span><span class='op'>)</span>, data <span class='op'>=</span> <span class='va'>d_syn</span>, - start <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>parent_0 <span class='op'>=</span> <span class='fl'>100</span>, lrc <span class='op'>=</span> <span class='op'>-</span><span class='fl'>3</span><span class='op'>)</span><span class='op'>)</span> -<span class='kw'><a href='https://rdrr.io/r/base/library.html'>library</a></span><span class='op'>(</span><span class='va'><a href='https://svn.r-project.org/R-packages/trunk/nlme/'>nlme</a></span><span class='op'>)</span> -<span class='va'>f_gnls</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/gnls.html'>gnls</a></span><span class='op'>(</span><span class='va'>value</span> <span class='op'>~</span> <span class='fu'><a href='https://rdrr.io/r/stats/SSasymp.html'>SSasymp</a></span><span class='op'>(</span><span class='va'>time</span>, <span class='fl'>0</span>, <span class='va'>parent_0</span>, <span class='va'>lrc</span><span class='op'>)</span>, - data <span class='op'>=</span> <span class='va'>d_syn</span>, na.action <span class='op'>=</span> <span class='va'>na.omit</span>, - start <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>parent_0 <span class='op'>=</span> <span class='fl'>100</span>, lrc <span class='op'>=</span> <span class='op'>-</span><span class='fl'>3</span><span class='op'>)</span><span class='op'>)</span> -<span class='kw'>if</span> <span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/length.html'>length</a></span><span class='op'>(</span><span class='fu'>findFunction</span><span class='op'>(</span><span class='st'>"varConstProp"</span><span class='op'>)</span><span class='op'>)</span> <span class='op'>></span> <span class='fl'>0</span><span class='op'>)</span> <span class='op'>{</span> - <span class='va'>f_gnls_tc</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_gnls</span>, weights <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/varConstProp.html'>varConstProp</a></span><span class='op'>(</span><span class='op'>)</span><span class='op'>)</span> - <span class='va'>f_gnls_tc_sf</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>f_gnls_tc</span>, control <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>sigma <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span><span class='op'>)</span> -<span class='op'>}</span> -<span class='va'>f_mkin</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>d_syn</span>, error_model <span class='op'>=</span> <span class='st'>"const"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>f_mkin_tc</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>d_syn</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='plot.mkinfit.html'>plot_res</a></span><span class='op'>(</span><span class='va'>f_mkin_tc</span>, standardized <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='img'><img src='sigma_twocomp-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/stats/AIC.html'>AIC</a></span><span class='op'>(</span><span class='va'>f_nls</span>, <span class='va'>f_gnls</span>, <span class='va'>f_gnls_tc</span>, <span class='va'>f_gnls_tc_sf</span>, <span class='va'>f_mkin</span>, <span class='va'>f_mkin_tc</span><span class='op'>)</span> -</div><div class='output co'>#> df AIC -#> f_nls 3 114.4817 -#> f_gnls 3 114.4817 -#> f_gnls_tc 5 103.6447 -#> f_gnls_tc_sf 4 101.6447 -#> f_mkin 3 114.4817 -#> f_mkin_tc 4 101.6446</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">times</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_pred</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>time <span class="op">=</span> <span class="va">times</span>, parent <span class="op">=</span> <span class="fl">100</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">exp</a></span><span class="op">(</span><span class="op">-</span> <span class="fl">0.03</span> <span class="op">*</span> <span class="va">times</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456</span><span class="op">)</span></span> +<span class="r-in"><span class="va">d_syn</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_pred</span>, <span class="kw">function</span><span class="op">(</span><span class="va">y</span><span class="op">)</span> <span class="fu">sigma_twocomp</span><span class="op">(</span><span class="va">y</span>, <span class="fl">1</span>, <span class="fl">0.07</span><span class="op">)</span>,</span> +<span class="r-in"> reps <span class="op">=</span> <span class="fl">2</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"><span class="va">f_nls</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/nls.html" class="external-link">nls</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu"><a href="https://rdrr.io/r/stats/SSasymp.html" class="external-link">SSasymp</a></span><span class="op">(</span><span class="va">time</span>, <span class="fl">0</span>, <span class="va">parent_0</span>, <span class="va">lrc</span><span class="op">)</span>, data <span class="op">=</span> <span class="va">d_syn</span>,</span> +<span class="r-in"> start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>parent_0 <span class="op">=</span> <span class="fl">100</span>, lrc <span class="op">=</span> <span class="op">-</span><span class="fl">3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_gnls</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/gnls.html" class="external-link">gnls</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu"><a href="https://rdrr.io/r/stats/SSasymp.html" class="external-link">SSasymp</a></span><span class="op">(</span><span class="va">time</span>, <span class="fl">0</span>, <span class="va">parent_0</span>, <span class="va">lrc</span><span class="op">)</span>,</span> +<span class="r-in"> data <span class="op">=</span> <span class="va">d_syn</span>, na.action <span class="op">=</span> <span class="va">na.omit</span>,</span> +<span class="r-in"> start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>parent_0 <span class="op">=</span> <span class="fl">100</span>, lrc <span class="op">=</span> <span class="op">-</span><span class="fl">3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="fu">findFunction</span><span class="op">(</span><span class="st">"varConstProp"</span><span class="op">)</span><span class="op">)</span> <span class="op">></span> <span class="fl">0</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="va">f_gnls_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_gnls</span>, weights <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/varConstProp.html" class="external-link">varConstProp</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"> <span class="va">f_gnls_tc_sf</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_gnls_tc</span>, control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>sigma <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"><span class="va">f_mkin</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">d_syn</span>, error_model <span class="op">=</span> <span class="st">"const"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">d_syn</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">f_mkin_tc</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-plt img"><img src="sigma_twocomp-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nls</span>, <span class="va">f_gnls</span>, <span class="va">f_gnls_tc</span>, <span class="va">f_gnls_tc_sf</span>, <span class="va">f_mkin</span>, <span class="va">f_mkin_tc</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> f_nls 3 114.4817</span> +<span class="r-out co"><span class="r-pr">#></span> f_gnls 3 114.4817</span> +<span class="r-out co"><span class="r-pr">#></span> f_gnls_tc 5 103.6447</span> +<span class="r-out co"><span class="r-pr">#></span> f_gnls_tc_sf 4 101.6447</span> +<span class="r-out co"><span class="r-pr">#></span> f_mkin 3 114.4817</span> +<span class="r-out co"><span class="r-pr">#></span> f_mkin_tc 4 101.6446</span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/summary.mkinfit.html b/docs/reference/summary.mkinfit.html index 67a50216..b4d25f4f 100644 --- a/docs/reference/summary.mkinfit.html +++ b/docs/reference/summary.mkinfit.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Summary method for class "mkinfit" — summary.mkinfit • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - -<!-- Font Awesome icons --> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous" /> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" /> - -<!-- clipboard.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script> - -<!-- headroom.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script> - -<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Summary method for class "mkinfit" — summary.mkinfit" /> -<meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters with +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "mkinfit" — summary.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " mkinfit summary.mkinfit><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters with some uncertainty statistics, the chi2 error levels calculated according to FOCUS guidance (2006) as defined therein, formation fractions, DT50 values and optionally the data, consisting of observed, predicted and residual -values." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +values."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ values." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ values." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ values." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,34 +62,27 @@ values." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Summary method for class "mkinfit"</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/summary.mkinfit.R'><code>R/summary.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.mkinfit.R" class="external-link"><code>R/summary.mkinfit.R</code></a></small> <div class="hidden name"><code>summary.mkinfit.Rd</code></div> </div> @@ -155,187 +94,188 @@ and optionally the data, consisting of observed, predicted and residual values.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>object</span>, data <span class='op'>=</span> <span class='cn'>TRUE</span>, distimes <span class='op'>=</span> <span class='cn'>TRUE</span>, alpha <span class='op'>=</span> <span class='fl'>0.05</span>, <span class='va'>...</span><span class='op'>)</span> - -<span class='co'># S3 method for summary.mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>an object of class <code><a href='mkinfit.html'>mkinfit</a></code>.</p></td> - </tr> - <tr> - <th>data</th> - <td><p>logical, indicating whether the data should be included in the -summary.</p></td> - </tr> - <tr> - <th>distimes</th> - <td><p>logical, indicating whether DT50 and DT90 values should be -included.</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>error level for confidence interval estimation from t -distribution</p></td> - </tr> - <tr> - <th>...</th> - <td><p>optional arguments passed to methods like <code>print</code>.</p></td> - </tr> - <tr> - <th>x</th> - <td><p>an object of class <code>summary.mkinfit</code>.</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>Number of digits to use for printing</p></td> - </tr> - </table> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, data <span class="op">=</span> <span class="cn">TRUE</span>, distimes <span class="op">=</span> <span class="cn">TRUE</span>, alpha <span class="op">=</span> <span class="fl">0.05</span>, <span class="va">...</span><span class="op">)</span> - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> +<span class="co"># S3 method for summary.mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> +<dt>data</dt> +<dd><p>logical, indicating whether the data should be included in the +summary.</p></dd> +<dt>distimes</dt> +<dd><p>logical, indicating whether DT50 and DT90 values should be +included.</p></dd> +<dt>alpha</dt> +<dd><p>error level for confidence interval estimation from t +distribution</p></dd> +<dt>...</dt> +<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> +<dt>x</dt> +<dd><p>an object of class <code>summary.mkinfit</code>.</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>The summary function returns a list with components, among others</p> -<dt>version, Rversion</dt><dd><p>The mkin and R versions used</p></dd> -<dt>date.fit, date.summary</dt><dd><p>The dates where the fit and the summary were +<dl><dt>version, Rversion</dt> +<dd><p>The mkin and R versions used</p></dd> +<dt>date.fit, date.summary</dt> +<dd><p>The dates where the fit and the summary were produced</p></dd> -<dt>diffs</dt><dd><p>The differential equations used in the model</p></dd> -<dt>use_of_ff</dt><dd><p>Was maximum or minimum use made of formation fractions</p></dd> -<dt>bpar</dt><dd><p>Optimised and backtransformed +<dt>diffs</dt> +<dd><p>The differential equations used in the model</p></dd> +<dt>use_of_ff</dt> +<dd><p>Was maximum or minimum use made of formation fractions</p></dd> +<dt>bpar</dt> +<dd><p>Optimised and backtransformed parameters</p></dd> -<dt>data</dt><dd><p>The data (see Description above).</p></dd> -<dt>start</dt><dd><p>The starting values and bounds, if applicable, for optimised +<dt>data</dt> +<dd><p>The data (see Description above).</p></dd> +<dt>start</dt> +<dd><p>The starting values and bounds, if applicable, for optimised parameters.</p></dd> -<dt>fixed</dt><dd><p>The values of fixed parameters.</p></dd> -<dt>errmin </dt><dd><p>The chi2 error levels for +<dt>fixed</dt> +<dd><p>The values of fixed parameters.</p></dd> +<dt>errmin </dt> +<dd><p>The chi2 error levels for each observed variable.</p></dd> -<dt>bparms.ode</dt><dd><p>All backtransformed ODE +<dt>bparms.ode</dt> +<dd><p>All backtransformed ODE parameters, for use as starting parameters for related models.</p></dd> -<dt>errparms</dt><dd><p>Error model parameters.</p></dd> -<dt>ff</dt><dd><p>The estimated formation fractions derived from the fitted +<dt>errparms</dt> +<dd><p>Error model parameters.</p></dd> +<dt>ff</dt> +<dd><p>The estimated formation fractions derived from the fitted model.</p></dd> -<dt>distimes</dt><dd><p>The DT50 and DT90 values for each observed variable.</p></dd> -<dt>SFORB</dt><dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> -The print method is called for its side effect, i.e. printing the summary. - - <h2 class="hasAnchor" id="references"><a class="anchor" href="#references"></a>References</h2> - - <p>FOCUS (2006) “Guidance Document on Estimating Persistence +<dt>distimes</dt> +<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> +<dt>SFORB</dt> +<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> +</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> + </div> + <div id="references"> + <h2>References</h2> + <p>FOCUS (2006) “Guidance Document on Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, +EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href='http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics'>http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span>, <span class='va'>FOCUS_2006_A</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> mkin version used for fitting: 1.0.3 -#> R version used for fitting: 4.0.3 -#> Date of fit: Mon Feb 15 13:46:11 2021 -#> Date of summary: Mon Feb 15 13:46:11 2021 -#> -#> Equations: -#> d_parent/dt = - k_parent * parent -#> -#> Model predictions using solution type analytical -#> -#> Fitted using 131 model solutions performed in 0.029 s -#> -#> Error model: Constant variance -#> -#> Error model algorithm: OLS -#> -#> Starting values for parameters to be optimised: -#> value type -#> parent_0 101.24 state -#> k_parent 0.10 deparm -#> -#> Starting values for the transformed parameters actually optimised: -#> value lower upper -#> parent_0 101.240000 -Inf Inf -#> log_k_parent -2.302585 -Inf Inf -#> -#> Fixed parameter values: -#> None -#> -#> Results: -#> -#> AIC BIC logLik -#> 55.28197 55.5203 -24.64099 -#> -#> Optimised, transformed parameters with symmetric confidence intervals: -#> Estimate Std. Error Lower Upper -#> parent_0 109.200 3.70400 99.630 118.700 -#> log_k_parent -3.291 0.09176 -3.527 -3.055 -#> sigma 5.266 1.31600 1.882 8.649 -#> -#> Parameter correlation: -#> parent_0 log_k_parent sigma -#> parent_0 1.000e+00 5.428e-01 1.642e-07 -#> log_k_parent 5.428e-01 1.000e+00 2.507e-07 -#> sigma 1.642e-07 2.507e-07 1.000e+00 -#> -#> Backtransformed parameters: -#> Confidence intervals for internally transformed parameters are asymmetric. -#> t-test (unrealistically) based on the assumption of normal distribution -#> for estimators of untransformed parameters. -#> Estimate t value Pr(>t) Lower Upper -#> parent_0 109.20000 29.47 4.218e-07 99.6300 118.70000 -#> k_parent 0.03722 10.90 5.650e-05 0.0294 0.04712 -#> sigma 5.26600 4.00 5.162e-03 1.8820 8.64900 -#> -#> FOCUS Chi2 error levels in percent: -#> err.min n.optim df -#> All data 8.385 2 6 -#> parent 8.385 2 6 -#> -#> Estimated disappearance times: -#> DT50 DT90 -#> parent 18.62 61.87 -#> -#> Data: -#> time variable observed predicted residual -#> 0 parent 101.24 109.153 -7.9132 -#> 3 parent 99.27 97.622 1.6484 -#> 7 parent 90.11 84.119 5.9913 -#> 14 parent 72.19 64.826 7.3641 -#> 30 parent 29.71 35.738 -6.0283 -#> 62 parent 5.98 10.862 -4.8818 -#> 90 parent 1.54 3.831 -2.2911 -#> 118 parent 0.39 1.351 -0.9613</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span>, <span class="va">FOCUS_2006_A</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:42:12 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:42:12 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted using 131 model solutions performed in 0.029 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 101.24 state</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.10 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 101.240000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.302585 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 55.28197 55.5203 -24.64099</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 109.200 3.70400 99.630 118.700</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -3.291 0.09176 -3.527 -3.055</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.266 1.31600 1.882 8.649</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent sigma</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 5.428e-01 1.642e-07</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent 5.428e-01 1.000e+00 2.507e-07</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.642e-07 2.507e-07 1.000e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 109.20000 29.47 4.218e-07 99.6300 118.70000</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.03722 10.90 5.650e-05 0.0294 0.04712</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 5.26600 4.00 5.162e-03 1.8820 8.64900</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 8.385 2 6</span> +<span class="r-out co"><span class="r-pr">#></span> parent 8.385 2 6</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 18.62 61.87</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> +<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.24 109.153 -7.9132</span> +<span class="r-out co"><span class="r-pr">#></span> 3 parent 99.27 97.622 1.6484</span> +<span class="r-out co"><span class="r-pr">#></span> 7 parent 90.11 84.119 5.9913</span> +<span class="r-out co"><span class="r-pr">#></span> 14 parent 72.19 64.826 7.3641</span> +<span class="r-out co"><span class="r-pr">#></span> 30 parent 29.71 35.738 -6.0283</span> +<span class="r-out co"><span class="r-pr">#></span> 62 parent 5.98 10.862 -4.8818</span> +<span class="r-out co"><span class="r-pr">#></span> 90 parent 1.54 3.831 -2.2911</span> +<span class="r-out co"><span class="r-pr">#></span> 118 parent 0.39 1.351 -0.9613</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/summary.nlme.mmkin.html b/docs/reference/summary.nlme.mmkin.html index 8df9011d..2bc50dac 100644 --- a/docs/reference/summary.nlme.mmkin.html +++ b/docs/reference/summary.nlme.mmkin.html @@ -1,71 +1,16 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - 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Optionally -(default is FALSE), the data are listed in full." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +(default is FALSE), the data are listed in full."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -76,13 +21,12 @@ endpoints such as formation fractions and DT50 values. Optionally </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -91,8 +35,7 @@ endpoints such as formation fractions and DT50 values. Optionally <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -102,6 +45,9 @@ endpoints such as formation fractions and DT50 values. Optionally <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -116,34 +62,27 @@ endpoints such as formation fractions and DT50 values. Optionally <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Summary method for class "nlme.mmkin"</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/summary.nlme.mmkin.R'><code>R/summary.nlme.mmkin.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.nlme.mmkin.R" class="external-link"><code>R/summary.nlme.mmkin.R</code></a></small> <div class="hidden name"><code>summary.nlme.mmkin.Rd</code></div> </div> @@ -155,295 +94,288 @@ endpoints such as formation fractions and DT50 values. Optionally (default is FALSE), the data are listed in full.</p> </div> - <pre class="usage"><span class='co'># S3 method for nlme.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span> - <span class='va'>object</span>, - data <span class='op'>=</span> <span class='cn'>FALSE</span>, - verbose <span class='op'>=</span> <span class='cn'>FALSE</span>, - distimes <span class='op'>=</span> <span class='cn'>TRUE</span>, - alpha <span class='op'>=</span> <span class='fl'>0.05</span>, - <span class='va'>...</span> -<span class='op'>)</span> - -<span class='co'># S3 method for summary.nlme.mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, verbose <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>verbose</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>an object of class <a href='nlme.mmkin.html'>nlme.mmkin</a></p></td> - </tr> - <tr> - <th>data</th> - <td><p>logical, indicating whether the full data should be included in -the summary.</p></td> - </tr> - <tr> - <th>verbose</th> - <td><p>Should the summary be verbose?</p></td> - </tr> - <tr> - <th>distimes</th> - <td><p>logical, indicating whether DT50 and DT90 values should be -included.</p></td> - </tr> - <tr> - <th>alpha</th> - <td><p>error level for confidence interval estimation from the t -distribution</p></td> - </tr> - <tr> - <th>...</th> - <td><p>optional arguments passed to methods like <code>print</code>.</p></td> - </tr> - <tr> - <th>x</th> - <td><p>an object of class summary.nlme.mmkin</p></td> - </tr> - <tr> - <th>digits</th> - <td><p>Number of digits to use for printing</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for nlme.mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span> + <span class="va">object</span>, + data <span class="op">=</span> <span class="cn">FALSE</span>, + verbose <span class="op">=</span> <span class="cn">FALSE</span>, + distimes <span class="op">=</span> <span class="cn">TRUE</span>, + alpha <span class="op">=</span> <span class="fl">0.05</span>, + <span class="va">...</span> +<span class="op">)</span> + +<span class="co"># S3 method for summary.nlme.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> - <p>The summary function returns a list based on the <a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a> object + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>an object of class <a href="nlme.mmkin.html">nlme.mmkin</a></p></dd> +<dt>data</dt> +<dd><p>logical, indicating whether the full data should be included in +the summary.</p></dd> +<dt>verbose</dt> +<dd><p>Should the summary be verbose?</p></dd> +<dt>distimes</dt> +<dd><p>logical, indicating whether DT50 and DT90 values should be +included.</p></dd> +<dt>alpha</dt> +<dd><p>error level for confidence interval estimation from the t +distribution</p></dd> +<dt>...</dt> +<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> +<dt>x</dt> +<dd><p>an object of class summary.nlme.mmkin</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>The summary function returns a list based on the <a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a> object obtained in the fit, with at least the following additional components</p> -<dt>nlmeversion, mkinversion, Rversion</dt><dd><p>The nlme, mkin and R versions used</p></dd> -<dt>date.fit, date.summary</dt><dd><p>The dates where the fit and the summary were +<dl><dt>nlmeversion, mkinversion, Rversion</dt> +<dd><p>The nlme, mkin and R versions used</p></dd> +<dt>date.fit, date.summary</dt> +<dd><p>The dates where the fit and the summary were produced</p></dd> -<dt>diffs</dt><dd><p>The differential equations used in the degradation model</p></dd> -<dt>use_of_ff</dt><dd><p>Was maximum or minimum use made of formation fractions</p></dd> -<dt>data</dt><dd><p>The data</p></dd> -<dt>confint_trans</dt><dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> -<dt>confint_back</dt><dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> -<dt>ff</dt><dd><p>The estimated formation fractions derived from the fitted +<dt>diffs</dt> +<dd><p>The differential equations used in the degradation model</p></dd> +<dt>use_of_ff</dt> +<dd><p>Was maximum or minimum use made of formation fractions</p></dd> +<dt>data</dt> +<dd><p>The data</p></dd> +<dt>confint_trans</dt> +<dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> +<dt>confint_back</dt> +<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> +<dt>ff</dt> +<dd><p>The estimated formation fractions derived from the fitted model.</p></dd> -<dt>distimes</dt><dd><p>The DT50 and DT90 values for each observed variable.</p></dd> -<dt>SFORB</dt><dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> -The print method is called for its side effect, i.e. printing the summary. - - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +<dt>distimes</dt> +<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> +<dt>SFORB</dt> +<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> +</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke for the mkin specific parts José Pinheiro and Douglas Bates for the components inherited from nlme</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='co'># Generate five datasets following SFO kinetics</span> -<span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> -<span class='va'>dt50_sfo_in_pop</span> <span class='op'><-</span> <span class='fl'>50</span> -<span class='va'>k_in_pop</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>2</span><span class='op'>)</span> <span class='op'>/</span> <span class='va'>dt50_sfo_in_pop</span> -<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>1234</span><span class='op'>)</span> -<span class='va'>k_in</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='fl'>5</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='va'>k_in_pop</span><span class='op'>)</span>, <span class='fl'>0.5</span><span class='op'>)</span> -<span class='va'>SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> - -<span class='va'>pred_sfo</span> <span class='op'><-</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>k</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>SFO</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='va'>k</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> -<span class='op'>}</span> - -<span class='va'>ds_sfo_mean</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>k_in</span>, <span class='va'>pred_sfo</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>ds_sfo_mean</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"ds"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span><span class='op'>)</span> - -<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>12345</span><span class='op'>)</span> -<span class='va'>ds_sfo_syn</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>ds_sfo_mean</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>ds</span>, - sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>sqrt</a></span><span class='op'>(</span><span class='fl'>1</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>+</span> <span class='va'>value</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>*</span> <span class='fl'>0.07</span><span class='op'>^</span><span class='fl'>2</span><span class='op'>)</span>, - n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span> -<span class='op'>}</span><span class='op'>)</span> - -<span class='co'># Evaluate using mmkin and nlme</span> -<span class='kw'><a href='https://rdrr.io/r/base/library.html'>library</a></span><span class='op'>(</span><span class='va'><a href='https://svn.r-project.org/R-packages/trunk/nlme/'>nlme</a></span><span class='op'>)</span> -<span class='va'>f_mmkin</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>ds_sfo_syn</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Optimisation did not converge:</span> -#> <span class='warning'>iteration limit reached without convergence (10)</span></div><div class='input'><span class='va'>f_nlme</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span><span class='op'>(</span><span class='va'>f_mmkin</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Iteration 4, LME step: nlminb() did not converge (code = 1). PORT message: false convergence (8)</span></div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>f_nlme</span>, data <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> nlme version used for fitting: 3.1.152 -#> mkin version used for pre-fitting: 1.0.4 -#> R version used for fitting: 4.0.4 -#> Date of fit: Wed Mar 31 19:18:24 2021 -#> Date of summary: Wed Mar 31 19:18:24 2021 -#> -#> Equations: -#> d_parent/dt = - k_parent * parent -#> -#> Data: -#> 90 observations of 1 variable(s) grouped in 5 datasets -#> -#> Model predictions using solution type analytical -#> -#> Fitted in 0.537 s using 4 iterations -#> -#> Variance model: Two-component variance function -#> -#> Mean of starting values for individual parameters: -#> parent_0 log_k_parent -#> 101.569 -4.454 -#> -#> Fixed degradation parameter values: -#> None -#> -#> Results: -#> -#> AIC BIC logLik -#> 584.5 599.5 -286.2 -#> -#> Optimised, transformed parameters with symmetric confidence intervals: -#> lower est. upper -#> parent_0 99.371 101.592 103.814 -#> log_k_parent -4.973 -4.449 -3.926 -#> -#> Correlation: -#> prnt_0 -#> log_k_parent 0.051 -#> -#> Random effects: -#> Formula: list(parent_0 ~ 1, log_k_parent ~ 1) -#> Level: ds -#> Structure: Diagonal -#> parent_0 log_k_parent Residual -#> StdDev: 6.924e-05 0.5863 1 -#> -#> Variance function: -#> Structure: Constant plus proportion of variance covariate -#> Formula: ~fitted(.) -#> Parameter estimates: -#> const prop -#> 0.0001208853 0.0789968036 -#> -#> Backtransformed parameters with asymmetric confidence intervals: -#> lower est. upper -#> parent_0 99.370882 101.59243 103.81398 -#> k_parent 0.006923 0.01168 0.01972 -#> -#> Estimated disappearance times: -#> DT50 DT90 -#> parent 59.32 197.1 -#> -#> Data: -#> ds name time observed predicted residual std standardized -#> ds 1 parent 0 104.1 101.592 2.50757 8.0255 0.312451 -#> ds 1 parent 0 105.0 101.592 3.40757 8.0255 0.424594 -#> ds 1 parent 1 98.5 100.796 -2.29571 7.9625 -0.288313 -#> ds 1 parent 1 96.1 100.796 -4.69571 7.9625 -0.589725 -#> ds 1 parent 3 101.9 99.221 2.67904 7.8381 0.341796 -#> ds 1 parent 3 85.2 99.221 -14.02096 7.8381 -1.788812 -#> ds 1 parent 7 99.1 96.145 2.95512 7.5951 0.389081 -#> ds 1 parent 7 93.0 96.145 -3.14488 7.5951 -0.414065 -#> ds 1 parent 14 88.1 90.989 -2.88944 7.1879 -0.401987 -#> ds 1 parent 14 84.1 90.989 -6.88944 7.1879 -0.958480 -#> ds 1 parent 28 80.2 81.493 -1.29305 6.4377 -0.200857 -#> ds 1 parent 28 91.3 81.493 9.80695 6.4377 1.523364 -#> ds 1 parent 60 65.1 63.344 1.75642 5.0039 0.351008 -#> ds 1 parent 60 65.8 63.344 2.45642 5.0039 0.490898 -#> ds 1 parent 90 47.8 50.018 -2.21764 3.9512 -0.561252 -#> ds 1 parent 90 53.5 50.018 3.48236 3.9512 0.881335 -#> ds 1 parent 120 37.6 39.495 -1.89515 3.1200 -0.607423 -#> ds 1 parent 120 39.3 39.495 -0.19515 3.1200 -0.062549 -#> ds 2 parent 0 107.9 101.592 6.30757 8.0255 0.785943 -#> ds 2 parent 0 102.1 101.592 0.50757 8.0255 0.063245 -#> ds 2 parent 1 103.8 100.058 3.74159 7.9043 0.473361 -#> ds 2 parent 1 108.6 100.058 8.54159 7.9043 1.080626 -#> ds 2 parent 3 91.0 97.060 -6.05952 7.6674 -0.790297 -#> ds 2 parent 3 84.9 97.060 -12.15952 7.6674 -1.585874 -#> ds 2 parent 7 79.3 91.329 -12.02867 7.2147 -1.667251 -#> ds 2 parent 7 100.9 91.329 9.57133 7.2147 1.326647 -#> ds 2 parent 14 77.3 82.102 -4.80185 6.4858 -0.740366 -#> ds 2 parent 14 83.5 82.102 1.39815 6.4858 0.215571 -#> ds 2 parent 28 66.8 66.351 0.44945 5.2415 0.085748 -#> ds 2 parent 28 63.3 66.351 -3.05055 5.2415 -0.582002 -#> ds 2 parent 60 40.8 40.775 0.02474 3.2211 0.007679 -#> ds 2 parent 60 44.8 40.775 4.02474 3.2211 1.249485 -#> ds 2 parent 90 27.8 25.832 1.96762 2.0407 0.964198 -#> ds 2 parent 90 27.0 25.832 1.16762 2.0407 0.572171 -#> ds 2 parent 120 15.2 16.366 -1.16561 1.2928 -0.901595 -#> ds 2 parent 120 15.5 16.366 -0.86561 1.2928 -0.669547 -#> ds 3 parent 0 97.7 101.592 -3.89243 8.0255 -0.485009 -#> ds 3 parent 0 88.2 101.592 -13.39243 8.0255 -1.668739 -#> ds 3 parent 1 109.9 99.218 10.68196 7.8379 1.362858 -#> ds 3 parent 1 97.8 99.218 -1.41804 7.8379 -0.180921 -#> ds 3 parent 3 100.5 94.634 5.86555 7.4758 0.784603 -#> ds 3 parent 3 77.4 94.634 -17.23445 7.4758 -2.305360 -#> ds 3 parent 7 78.3 86.093 -7.79273 6.8011 -1.145813 -#> ds 3 parent 7 90.3 86.093 4.20727 6.8011 0.618620 -#> ds 3 parent 14 76.0 72.958 3.04222 5.7634 0.527848 -#> ds 3 parent 14 79.1 72.958 6.14222 5.7634 1.065722 -#> ds 3 parent 28 46.0 52.394 -6.39404 4.1390 -1.544842 -#> ds 3 parent 28 53.4 52.394 1.00596 4.1390 0.243046 -#> ds 3 parent 60 25.1 24.582 0.51786 1.9419 0.266676 -#> ds 3 parent 60 21.4 24.582 -3.18214 1.9419 -1.638664 -#> ds 3 parent 90 11.0 12.092 -1.09202 0.9552 -1.143199 -#> ds 3 parent 90 14.2 12.092 2.10798 0.9552 2.206776 -#> ds 3 parent 120 5.8 5.948 -0.14810 0.4699 -0.315178 -#> ds 3 parent 120 6.1 5.948 0.15190 0.4699 0.323282 -#> ds 4 parent 0 95.3 101.592 -6.29243 8.0255 -0.784057 -#> ds 4 parent 0 102.0 101.592 0.40757 8.0255 0.050784 -#> ds 4 parent 1 104.4 101.125 3.27549 7.9885 0.410025 -#> ds 4 parent 1 105.4 101.125 4.27549 7.9885 0.535205 -#> ds 4 parent 3 113.7 100.195 13.50487 7.9151 1.706218 -#> ds 4 parent 3 82.3 100.195 -17.89513 7.9151 -2.260886 -#> ds 4 parent 7 98.1 98.362 -0.26190 7.7703 -0.033706 -#> ds 4 parent 7 87.8 98.362 -10.56190 7.7703 -1.359270 -#> ds 4 parent 14 97.9 95.234 2.66590 7.5232 0.354357 -#> ds 4 parent 14 104.8 95.234 9.56590 7.5232 1.271521 -#> ds 4 parent 28 85.0 89.274 -4.27372 7.0523 -0.606001 -#> ds 4 parent 28 77.2 89.274 -12.07372 7.0523 -1.712017 -#> ds 4 parent 60 82.2 77.013 5.18661 6.0838 0.852526 -#> ds 4 parent 60 86.1 77.013 9.08661 6.0838 1.493571 -#> ds 4 parent 90 70.5 67.053 3.44692 5.2970 0.650733 -#> ds 4 parent 90 61.7 67.053 -5.35308 5.2970 -1.010591 -#> ds 4 parent 120 60.0 58.381 1.61905 4.6119 0.351058 -#> ds 4 parent 120 56.4 58.381 -1.98095 4.6119 -0.429530 -#> ds 5 parent 0 92.6 101.592 -8.99243 8.0255 -1.120485 -#> ds 5 parent 0 116.5 101.592 14.90757 8.0255 1.857531 -#> ds 5 parent 1 108.0 99.914 8.08560 7.8929 1.024413 -#> ds 5 parent 1 104.9 99.914 4.98560 7.8929 0.631655 -#> ds 5 parent 3 100.5 96.641 3.85898 7.6343 0.505477 -#> ds 5 parent 3 89.5 96.641 -7.14102 7.6343 -0.935382 -#> ds 5 parent 7 91.7 90.412 1.28752 7.1423 0.180267 -#> ds 5 parent 7 95.1 90.412 4.68752 7.1423 0.656304 -#> ds 5 parent 14 82.2 80.463 1.73715 6.3563 0.273295 -#> ds 5 parent 14 84.5 80.463 4.03715 6.3563 0.635141 -#> ds 5 parent 28 60.5 63.728 -3.22788 5.0343 -0.641178 -#> ds 5 parent 28 72.8 63.728 9.07212 5.0343 1.802062 -#> ds 5 parent 60 38.3 37.399 0.90061 2.9544 0.304835 -#> ds 5 parent 60 40.7 37.399 3.30061 2.9544 1.117174 -#> ds 5 parent 90 22.5 22.692 -0.19165 1.7926 -0.106913 -#> ds 5 parent 90 20.8 22.692 -1.89165 1.7926 -1.055273 -#> ds 5 parent 120 13.4 13.768 -0.36790 1.0876 -0.338259 -#> ds 5 parent 120 13.8 13.768 0.03210 1.0876 0.029517</div><div class='input'> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="co"># Generate five datasets following SFO kinetics</span></span> +<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dt50_sfo_in_pop</span> <span class="op"><-</span> <span class="fl">50</span></span> +<span class="r-in"><span class="va">k_in_pop</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span> <span class="op">/</span> <span class="va">dt50_sfo_in_pop</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="va">k_in_pop</span><span class="op">)</span>, <span class="fl">0.5</span><span class="op">)</span></span> +<span class="r-in"><span class="va">SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">pred_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">SFO</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="va">k</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_sfo_mean</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">k_in</span>, <span class="va">pred_sfo</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_sfo_mean</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">12345</span><span class="op">)</span></span> +<span class="r-in"><span class="va">ds_sfo_syn</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_sfo_mean</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span> +<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span> +<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Evaluate using mmkin and nlme</span></span> +<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">ds_sfo_syn</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlme</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> nlme version used for fitting: 3.1.155 </span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:42:16 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:42:16 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted in 0.545 s using 4 iterations</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent </span> +<span class="r-out co"><span class="r-pr">#></span> 101.569 -4.454 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> None</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 584.5 599.5 -286.2</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.371 101.592 103.814</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -4.973 -4.449 -3.926</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> +<span class="r-out co"><span class="r-pr">#></span> parnt_0</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent 0.0507 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent ~ 1)</span> +<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent Residual</span> +<span class="r-out co"><span class="r-pr">#></span> StdDev: 6.924e-05 0.5863 1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> +<span class="r-out co"><span class="r-pr">#></span> Structure: Constant plus proportion of variance covariate</span> +<span class="r-out co"><span class="r-pr">#></span> Formula: ~fitted(.) </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> +<span class="r-out co"><span class="r-pr">#></span> const prop </span> +<span class="r-out co"><span class="r-pr">#></span> 0.0001208853 0.0789968036 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters with asymmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.370882 101.59243 103.81398</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.006923 0.01168 0.01972</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 59.32 197.1</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> ds name time observed predicted residual std standardized</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 104.1 101.592 2.50757 8.0255 0.312451</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 105.0 101.592 3.40757 8.0255 0.424594</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 98.5 100.796 -2.29571 7.9625 -0.288313</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 96.1 100.796 -4.69571 7.9625 -0.589725</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 101.9 99.221 2.67904 7.8381 0.341796</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 85.2 99.221 -14.02096 7.8381 -1.788812</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 99.1 96.145 2.95512 7.5951 0.389081</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 93.0 96.145 -3.14488 7.5951 -0.414065</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 88.1 90.989 -2.88944 7.1879 -0.401987</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 84.1 90.989 -6.88944 7.1879 -0.958480</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 80.2 81.493 -1.29305 6.4377 -0.200857</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 91.3 81.493 9.80695 6.4377 1.523364</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 65.1 63.344 1.75642 5.0039 0.351008</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 65.8 63.344 2.45642 5.0039 0.490898</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 47.8 50.018 -2.21764 3.9512 -0.561252</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 53.5 50.018 3.48236 3.9512 0.881335</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 37.6 39.495 -1.89515 3.1200 -0.607423</span> +<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 39.3 39.495 -0.19515 3.1200 -0.062549</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 107.9 101.592 6.30757 8.0255 0.785943</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 102.1 101.592 0.50757 8.0255 0.063245</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 103.8 100.058 3.74159 7.9043 0.473361</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 108.6 100.058 8.54159 7.9043 1.080626</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 91.0 97.060 -6.05952 7.6674 -0.790297</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 84.9 97.060 -12.15952 7.6674 -1.585874</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 79.3 91.329 -12.02867 7.2147 -1.667251</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 100.9 91.329 9.57133 7.2147 1.326647</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 77.3 82.102 -4.80185 6.4858 -0.740366</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 83.5 82.102 1.39815 6.4858 0.215571</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 66.8 66.351 0.44945 5.2415 0.085748</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 63.3 66.351 -3.05055 5.2415 -0.582002</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 40.8 40.775 0.02474 3.2211 0.007679</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 44.8 40.775 4.02474 3.2211 1.249485</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 27.8 25.832 1.96762 2.0407 0.964198</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 27.0 25.832 1.16762 2.0407 0.572171</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 15.2 16.366 -1.16561 1.2928 -0.901595</span> +<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 15.5 16.366 -0.86561 1.2928 -0.669547</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 97.7 101.592 -3.89243 8.0255 -0.485009</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 88.2 101.592 -13.39243 8.0255 -1.668739</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 109.9 99.218 10.68196 7.8379 1.362858</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 97.8 99.218 -1.41804 7.8379 -0.180921</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 100.5 94.634 5.86555 7.4758 0.784603</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 77.4 94.634 -17.23445 7.4758 -2.305360</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 78.3 86.093 -7.79273 6.8011 -1.145813</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 90.3 86.093 4.20727 6.8011 0.618620</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 76.0 72.958 3.04222 5.7634 0.527848</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 79.1 72.958 6.14222 5.7634 1.065722</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 46.0 52.394 -6.39404 4.1390 -1.544842</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 53.4 52.394 1.00596 4.1390 0.243046</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 25.1 24.582 0.51786 1.9419 0.266676</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 21.4 24.582 -3.18214 1.9419 -1.638664</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 11.0 12.092 -1.09202 0.9552 -1.143199</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 14.2 12.092 2.10798 0.9552 2.206776</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 5.8 5.948 -0.14810 0.4699 -0.315178</span> +<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 6.1 5.948 0.15190 0.4699 0.323282</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 95.3 101.592 -6.29243 8.0255 -0.784057</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 102.0 101.592 0.40757 8.0255 0.050784</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 104.4 101.125 3.27549 7.9885 0.410025</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 105.4 101.125 4.27549 7.9885 0.535205</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 113.7 100.195 13.50487 7.9151 1.706218</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 82.3 100.195 -17.89513 7.9151 -2.260886</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 98.1 98.362 -0.26190 7.7703 -0.033706</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 87.8 98.362 -10.56190 7.7703 -1.359270</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 97.9 95.234 2.66590 7.5232 0.354357</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 104.8 95.234 9.56590 7.5232 1.271521</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 85.0 89.274 -4.27372 7.0523 -0.606001</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 77.2 89.274 -12.07372 7.0523 -1.712017</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 82.2 77.013 5.18661 6.0838 0.852526</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 86.1 77.013 9.08661 6.0838 1.493571</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 70.5 67.053 3.44692 5.2970 0.650733</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 61.7 67.053 -5.35308 5.2970 -1.010591</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 60.0 58.381 1.61905 4.6119 0.351058</span> +<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 56.4 58.381 -1.98095 4.6119 -0.429530</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 92.6 101.592 -8.99243 8.0255 -1.120485</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 116.5 101.592 14.90757 8.0255 1.857531</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 108.0 99.914 8.08560 7.8929 1.024413</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 104.9 99.914 4.98560 7.8929 0.631655</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 100.5 96.641 3.85898 7.6343 0.505477</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 89.5 96.641 -7.14102 7.6343 -0.935382</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 91.7 90.412 1.28752 7.1423 0.180267</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 95.1 90.412 4.68752 7.1423 0.656304</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 82.2 80.463 1.73715 6.3563 0.273295</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 84.5 80.463 4.03715 6.3563 0.635141</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 60.5 63.728 -3.22788 5.0343 -0.641178</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 72.8 63.728 9.07212 5.0343 1.802062</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 38.3 37.399 0.90061 2.9544 0.304835</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 40.7 37.399 3.30061 2.9544 1.117174</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 22.5 22.692 -0.19165 1.7926 -0.106913</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 20.8 22.692 -1.89165 1.7926 -1.055273</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 13.4 13.768 -0.36790 1.0876 -0.338259</span> +<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 13.8 13.768 0.03210 1.0876 0.029517</span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - 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summary.nlmixr.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " nlmixr.mmkin summary.nlmixr.mmkin><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters +for fixed effects (population), random effects (deviations from the +population mean) and residual error model, as well as the resulting +endpoints such as formation fractions and DT50 values. Optionally +(default is FALSE), the data are listed in full."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> +<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> +<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + + + <div class="container template-reference-topic"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <div class="container"> + <div class="navbar-header"> + <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> + <span class="sr-only">Toggle navigation</span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + </button> + <span class="navbar-brand"> + <a class="navbar-link" href="../index.html">mkin</a> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> + </span> + </div> + + <div id="navbar" class="navbar-collapse collapse"> + <ul class="nav navbar-nav"><li> + <a href="../reference/index.html">Functions and data</a> +</li> +<li class="dropdown"> + <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + Articles + + <span class="caret"></span> + </a> + <ul class="dropdown-menu" role="menu"><li> + <a href="../articles/mkin.html">Introduction to mkin</a> + </li> + <li> + <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + </li> + <li> + <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Summary method for class "nlmixr.mmkin"</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.nlmixr.mmkin.R" class="external-link"><code>R/summary.nlmixr.mmkin.R</code></a></small> + <div class="hidden name"><code>summary.nlmixr.mmkin.Rd</code></div> + </div> + + <div class="ref-description"> + <p>Lists model equations, initial parameter values, optimised parameters +for fixed effects (population), random effects (deviations from the +population mean) and residual error model, as well as the resulting +endpoints such as formation fractions and DT50 values. Optionally +(default is FALSE), the data are listed in full.</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for nlmixr.mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, verbose <span class="op">=</span> <span class="cn">FALSE</span>, distimes <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for summary.nlmixr.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>an object of class <a href="nlmixr.mmkin.html">nlmixr.mmkin</a></p></dd> +<dt>data</dt> +<dd><p>logical, indicating whether the full data should be included in +the summary.</p></dd> +<dt>verbose</dt> +<dd><p>Should the summary be verbose?</p></dd> +<dt>distimes</dt> +<dd><p>logical, indicating whether DT50 and DT90 values should be +included.</p></dd> +<dt>...</dt> +<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> +<dt>x</dt> +<dd><p>an object of class summary.nlmixr.mmkin</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>The summary function returns a list obtained in the fit, with at +least the following additional components</p> +<dl><dt>nlmixrversion, mkinversion, Rversion</dt> +<dd><p>The nlmixr, mkin and R versions used</p></dd> +<dt>date.fit, date.summary</dt> +<dd><p>The dates where the fit and the summary were +produced</p></dd> +<dt>diffs</dt> +<dd><p>The differential equations used in the degradation model</p></dd> +<dt>use_of_ff</dt> +<dd><p>Was maximum or minimum use made of formation fractions</p></dd> +<dt>data</dt> +<dd><p>The data</p></dd> +<dt>confint_back</dt> +<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> +<dt>ff</dt> +<dd><p>The estimated formation fractions derived from the fitted +model.</p></dd> +<dt>distimes</dt> +<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> +<dt>SFORB</dt> +<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> +</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> + </div> + <div id="author"> + <h2>Author</h2> + <p>Johannes Ranke for the mkin specific parts +nlmixr authors for the parts inherited from nlmixr.</p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># Generate five datasets following DFOP-SFO kinetics</span></span> +<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.1</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k2_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"><span class="va">g_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_parent_to_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">pred_dfop_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">f_parent_to_m1</span>, <span class="va">k_m1</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1</span>, k2 <span class="op">=</span> <span class="va">k2</span>, g <span class="op">=</span> <span class="va">g</span>, f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1</span>, k_m1 <span class="op">=</span> <span class="va">k_m1</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_mean_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k2 <span class="op">=</span> <span class="va">k2_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, g <span class="op">=</span> <span class="va">g_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>,</span> +<span class="r-in"> f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k_m1 <span class="op">=</span> <span class="va">k_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_syn_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span> +<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span> +<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="co"># Evaluate using mmkin and nlmixr</span></span> +<span class="r-in"><span class="va">f_mmkin_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds_syn_dfop_sfo</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_saemix_dfop_sfo</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_nlme_dfop_sfo</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> With est = 'saem', a different error model is required for each observed variableChanging the error model to 'obs_tc' (Two-component error for each observed variable)</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-out co"><span class="r-pr">#></span> 1: 99.5921 -3.9040 -2.1350 -3.7103 -2.0097 0.3217 6.6502 0.1520 0.5415 0.1995 0.3705 0.5588 7.9084 0.0824 7.5666 0.1777</span> +<span class="r-out co"><span class="r-pr">#></span> 2: 99.9835 -3.8650 -2.3586 -4.0306 -1.6536 0.0696 6.3177 0.1590 0.5144 0.1895 0.3520 0.5308 4.7746 0.0649 4.5667 0.0865</span> +<span class="r-out co"><span class="r-pr">#></span> 3: 1.0014e+02 -4.0173e+00 -2.3869e+00 -4.0840e+00 -1.2338e+00 3.4899e-02 6.0018e+00 1.5109e-01 4.8870e-01 1.8005e-01 3.3438e-01 5.0428e-01 2.8890e+00 7.0377e-02 2.9045e+00 9.5437e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 4: 1.0024e+02 -4.1414e+00 -2.4972e+00 -4.1082e+00 -1.0291e+00 -1.0684e-02 5.7017e+00 1.4354e-01 4.6427e-01 1.7105e-01 3.1766e-01 4.7907e-01 2.1715e+00 8.9921e-02 1.8765e+00 1.0403e-01</span> +<span class="r-out co"><span class="r-pr">#></span> 5: 1.0068e+02 -4.1132e+00 -2.4776e+00 -4.0576e+00 -1.0391e+00 -8.8738e-02 5.8192e+00 1.3636e-01 4.4106e-01 1.6249e-01 3.0177e-01 4.5512e-01 1.6349e+00 8.3197e-02 1.4947e+00 1.0221e-01</span> +<span class="r-out co"><span class="r-pr">#></span> 6: 1.0044e+02 -4.0883e+00 -2.3931e+00 -4.1068e+00 -9.5058e-01 -1.2696e-01 5.5283e+00 1.2954e-01 4.1900e-01 1.5437e-01 2.8669e-01 4.5581e-01 1.4126e+00 8.1219e-02 1.2286e+00 1.0043e-01</span> +<span class="r-out co"><span class="r-pr">#></span> 7: 1.0103e+02 -4.0833e+00 -2.4194e+00 -4.0894e+00 -9.8547e-01 5.2360e-03 9.8755e+00 1.2306e-01 3.9805e-01 1.4665e-01 2.7235e-01 5.3394e-01 1.3620e+00 7.9842e-02 1.0649e+00 1.0298e-01</span> +<span class="r-out co"><span class="r-pr">#></span> 8: 1.0106e+02 -4.0535e+00 -2.3489e+00 -4.0682e+00 -9.4455e-01 -9.4310e-02 9.3818e+00 1.1691e-01 3.7815e-01 1.3932e-01 2.5873e-01 5.0724e-01 1.2163e+00 7.0820e-02 1.0147e+00 9.2362e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 9: 1.0150e+02 -4.0498e+00 -2.4037e+00 -4.0719e+00 -9.3384e-01 -1.2384e-01 8.9127e+00 1.1107e-01 3.5924e-01 1.3235e-01 2.4580e-01 5.3463e-01 1.0849e+00 7.7513e-02 9.8295e-01 8.5927e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 10: 1.0089e+02 -4.0313e+00 -2.3670e+00 -4.0573e+00 -9.0269e-01 -1.6427e-01 8.4670e+00 1.0551e-01 3.4128e-01 1.2573e-01 2.3351e-01 5.4980e-01 1.1274e+00 7.6000e-02 9.8582e-01 8.9740e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 11: 1.0089e+02 -4.0664e+00 -2.3547e+00 -4.0554e+00 -9.3659e-01 -1.6900e-01 8.0437e+00 1.0024e-01 3.2422e-01 1.1945e-01 2.2183e-01 5.2231e-01 1.1513e+00 7.5801e-02 9.7638e-01 8.5324e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 12: 1.0067e+02 -4.0427e+00 -2.3729e+00 -4.0413e+00 -9.2169e-01 -2.0927e-01 8.6156e+00 9.5225e-02 3.0801e-01 1.1348e-01 2.1074e-01 6.0288e-01 1.1918e+00 7.4830e-02 9.1899e-01 8.7983e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 13: 1.0042e+02 -4.0387e+00 -2.3650e+00 -4.0623e+00 -9.3973e-01 -2.2277e-01 8.1848e+00 9.0463e-02 2.9260e-01 1.0780e-01 2.0020e-01 5.7274e-01 1.1022e+00 7.3652e-02 9.1657e-01 8.7973e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 14: 1.0020e+02 -4.0227e+00 -2.3586e+00 -4.0333e+00 -9.4451e-01 -1.8020e-01 7.7756e+00 8.5940e-02 2.7797e-01 1.0241e-01 1.9019e-01 5.4410e-01 1.0728e+00 8.0169e-02 7.8974e-01 9.0162e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 15: 1.0045e+02 -4.0209e+00 -2.3544e+00 -4.0187e+00 -8.9758e-01 -2.4348e-01 7.3868e+00 8.1643e-02 2.6408e-01 9.7291e-02 1.8068e-01 6.4534e-01 1.0287e+00 7.9387e-02 7.3357e-01 9.0858e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 16: 1.0061e+02 -4.0195e+00 -2.3678e+00 -4.0419e+00 -8.9130e-01 -2.4248e-01 7.0175e+00 7.7561e-02 2.5087e-01 9.2427e-02 1.7165e-01 6.7145e-01 1.0440e+00 7.9292e-02 8.4681e-01 8.5285e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 17: 1.0034e+02 -4.0298e+00 -2.3685e+00 -4.0637e+00 -8.9550e-01 -1.0712e-01 6.6666e+00 7.3683e-02 2.3833e-01 8.7805e-02 1.6307e-01 6.3788e-01 1.0827e+00 7.1441e-02 8.5278e-01 8.8090e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 18: 99.8774 -4.0600 -2.3805 -4.0726 -0.9545 -0.1196 6.3333 0.0700 0.2264 0.0834 0.1549 0.6060 1.0056 0.0751 0.8017 0.0877</span> +<span class="r-out co"><span class="r-pr">#></span> 19: 1.0055e+02 -4.0731e+00 -2.2711e+00 -4.0824e+00 -9.5827e-01 -5.9764e-02 6.0166e+00 6.6499e-02 2.1509e-01 7.9244e-02 1.4717e-01 5.7835e-01 9.3185e-01 7.9396e-02 8.2332e-01 9.1277e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 20: 1.0060e+02 -4.1023e+00 -2.2841e+00 -4.0757e+00 -9.7931e-01 -1.0440e-01 5.7158e+00 6.3174e-02 2.0434e-01 7.5282e-02 1.3981e-01 6.4675e-01 1.0006e+00 7.7840e-02 8.7958e-01 9.1512e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 21: 1.0095e+02 -4.0955e+00 -2.3274e+00 -4.1038e+00 -9.5611e-01 -5.2481e-02 5.8063e+00 6.0015e-02 1.9412e-01 7.1518e-02 1.3282e-01 6.4943e-01 1.0926e+00 7.2665e-02 9.0450e-01 8.6278e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 22: 1.0083e+02 -4.0789e+00 -2.3108e+00 -4.1074e+00 -9.6548e-01 -4.9665e-02 5.5160e+00 5.7014e-02 1.8441e-01 6.7942e-02 1.2618e-01 6.7304e-01 9.3297e-01 8.1042e-02 8.9206e-01 9.2336e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 23: 1.0114e+02 -4.0924e+00 -2.4027e+00 -4.0947e+00 -9.7291e-01 -5.0773e-02 5.2567e+00 5.4164e-02 1.7519e-01 6.5747e-02 1.1987e-01 7.3402e-01 9.7858e-01 8.2133e-02 8.4928e-01 8.8254e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 24: 1.0151e+02 -4.0787e+00 -2.3696e+00 -4.0712e+00 -9.5647e-01 -5.4136e-02 4.9938e+00 5.1456e-02 1.6643e-01 6.2460e-02 1.1388e-01 7.1847e-01 9.7548e-01 7.7691e-02 9.0418e-01 8.9115e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 25: 1.0158e+02 -4.0830e+00 -2.3384e+00 -4.0705e+00 -9.5727e-01 -8.4974e-02 4.7442e+00 4.8883e-02 1.5811e-01 5.9337e-02 1.0818e-01 6.8255e-01 1.0340e+00 7.4497e-02 9.0691e-01 9.0886e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 26: 1.0156e+02 -4.0784e+00 -2.3030e+00 -4.1027e+00 -9.5638e-01 -4.9456e-03 4.5069e+00 4.6439e-02 1.5021e-01 5.6370e-02 1.1189e-01 6.4842e-01 1.0537e+00 7.7612e-02 9.6725e-01 8.7824e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 27: 1.0198e+02 -4.0828e+00 -2.3006e+00 -4.0803e+00 -9.9402e-01 -8.3280e-02 4.2816e+00 4.4117e-02 1.4270e-01 5.3552e-02 1.3300e-01 6.1600e-01 9.1051e-01 7.7677e-02 9.5949e-01 8.6552e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 28: 1.0183e+02 -4.0871e+00 -2.2822e+00 -4.0596e+00 -9.9920e-01 -1.1469e-01 4.0675e+00 4.1911e-02 1.3556e-01 5.0874e-02 1.4021e-01 5.8520e-01 1.0294e+00 7.0917e-02 8.6440e-01 9.0301e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 29: 1.0171e+02 -4.0838e+00 -2.2606e+00 -4.0885e+00 -9.8937e-01 -6.6488e-02 4.3393e+00 3.9815e-02 1.2878e-01 4.8330e-02 1.3320e-01 5.5594e-01 1.0042e+00 8.1585e-02 8.5434e-01 8.6032e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 30: 1.0177e+02 -4.0861e+00 -2.2615e+00 -4.0670e+00 -9.9119e-01 -1.1322e-01 6.3058e+00 3.7825e-02 1.2942e-01 4.5914e-02 1.4223e-01 5.2814e-01 9.6301e-01 7.3336e-02 9.2366e-01 8.9276e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 31: 1.0160e+02 -4.0900e+00 -2.2455e+00 -4.0514e+00 -9.8754e-01 -2.2617e-01 5.9905e+00 3.5933e-02 1.2295e-01 4.3618e-02 1.3512e-01 5.2898e-01 1.0441e+00 7.6262e-02 1.0227e+00 8.3759e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 32: 1.0193e+02 -4.0967e+00 -2.2599e+00 -4.0295e+00 -9.8917e-01 -1.6626e-01 5.6910e+00 3.4137e-02 1.2620e-01 4.1437e-02 1.4303e-01 5.0253e-01 9.8083e-01 7.4136e-02 1.0031e+00 8.5124e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 33: 1.0215e+02 -4.0713e+00 -2.2563e+00 -4.0313e+00 -9.7361e-01 -1.8246e-01 5.4065e+00 3.2430e-02 1.1989e-01 3.9365e-02 1.5371e-01 4.7741e-01 9.6935e-01 8.0491e-02 9.7610e-01 8.0590e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 34: 1.0251e+02 -4.0707e+00 -2.2635e+00 -4.0387e+00 -9.2149e-01 -1.3452e-01 6.3940e+00 3.0808e-02 1.1389e-01 3.7397e-02 1.6720e-01 4.5354e-01 9.2449e-01 7.4355e-02 1.0505e+00 8.3049e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 35: 1.0278e+02 -4.0579e+00 -2.2877e+00 -4.0289e+00 -9.6632e-01 -1.2910e-01 6.0743e+00 2.9268e-02 1.0820e-01 3.5527e-02 1.7242e-01 4.3086e-01 1.0129e+00 7.3224e-02 1.0035e+00 7.9411e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 36: 1.0283e+02 -4.0771e+00 -2.2977e+00 -4.0108e+00 -9.5228e-01 -2.1781e-01 5.7706e+00 2.7805e-02 1.0279e-01 3.3751e-02 1.7034e-01 4.0932e-01 9.0249e-01 7.9917e-02 9.4562e-01 8.2391e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 37: 1.0228e+02 -4.0442e+00 -2.3061e+00 -4.0150e+00 -9.5376e-01 -1.4873e-01 5.4821e+00 2.6414e-02 9.7651e-02 3.2063e-02 1.7772e-01 3.8885e-01 9.0446e-01 8.1418e-02 9.7276e-01 8.3331e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 38: 1.0220e+02 -4.0454e+00 -2.3204e+00 -4.0207e+00 -9.3198e-01 -1.9324e-01 5.2080e+00 2.5094e-02 1.0946e-01 3.0460e-02 1.6883e-01 3.6941e-01 8.9159e-01 7.8645e-02 9.5848e-01 8.2734e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 39: 1.0193e+02 -4.0306e+00 -2.2926e+00 -4.0131e+00 -9.3448e-01 -2.1869e-01 6.7005e+00 2.3839e-02 1.0399e-01 2.8937e-02 1.6039e-01 3.5571e-01 9.0078e-01 7.8982e-02 9.3495e-01 8.3462e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 40: 1.0217e+02 -4.0463e+00 -2.2823e+00 -4.0209e+00 -9.2912e-01 -2.3580e-01 8.7857e+00 2.2647e-02 9.8789e-02 2.7490e-02 1.5418e-01 3.3792e-01 8.5126e-01 7.8849e-02 9.5510e-01 8.3011e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 41: 1.0210e+02 -4.0564e+00 -2.2213e+00 -4.0041e+00 -9.4137e-01 -2.4103e-01 9.2761e+00 2.1515e-02 9.5179e-02 2.6116e-02 1.4795e-01 3.9870e-01 9.8312e-01 7.1947e-02 1.0015e+00 8.1407e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 42: 1.0201e+02 -4.0204e+00 -2.2598e+00 -3.9984e+00 -9.4412e-01 -2.6838e-01 8.8123e+00 2.0439e-02 9.0420e-02 2.4810e-02 1.5013e-01 4.0334e-01 9.5583e-01 7.5617e-02 9.5131e-01 8.2343e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 43: 1.0244e+02 -4.0107e+00 -2.2178e+00 -3.9923e+00 -9.4481e-01 -3.1831e-01 8.3717e+00 1.9417e-02 9.5791e-02 2.3569e-02 1.5440e-01 4.8194e-01 9.4582e-01 7.4374e-02 9.7798e-01 8.3391e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 44: 1.0211e+02 -4.0193e+00 -2.2379e+00 -3.9784e+00 -9.2192e-01 -3.0224e-01 7.9531e+00 1.8446e-02 9.1002e-02 2.6623e-02 1.4668e-01 4.5785e-01 9.4162e-01 7.4503e-02 9.3229e-01 7.8428e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 45: 1.0183e+02 -4.0198e+00 -2.2150e+00 -3.9966e+00 -9.6219e-01 -3.0236e-01 7.5554e+00 1.7524e-02 8.6452e-02 2.8045e-02 1.4346e-01 4.3495e-01 9.3318e-01 7.5937e-02 9.4917e-01 8.2946e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 46: 1.0132e+02 -4.0245e+00 -2.2215e+00 -3.9954e+00 -9.4368e-01 -2.6878e-01 7.1777e+00 1.6648e-02 9.5839e-02 2.6909e-02 1.4633e-01 4.1321e-01 9.7698e-01 7.1947e-02 9.6599e-01 8.3812e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 47: 1.0138e+02 -4.0076e+00 -2.2741e+00 -4.0047e+00 -9.0608e-01 -2.2839e-01 6.8188e+00 1.5815e-02 9.2192e-02 2.5563e-02 1.6160e-01 3.9255e-01 9.3678e-01 7.4216e-02 1.0295e+00 7.9396e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 48: 1.0102e+02 -4.0235e+00 -2.2764e+00 -4.0123e+00 -9.1050e-01 -2.0555e-01 6.4778e+00 1.5024e-02 8.7583e-02 2.4285e-02 1.6368e-01 3.7292e-01 9.2204e-01 7.6976e-02 1.0289e+00 8.1381e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 49: 1.0074e+02 -4.0407e+00 -2.2583e+00 -4.0142e+00 -9.2682e-01 -2.5941e-01 6.1540e+00 1.4273e-02 8.3203e-02 2.3071e-02 1.8251e-01 3.5427e-01 9.0436e-01 7.4192e-02 1.0237e+00 8.2178e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 50: 1.0046e+02 -4.0626e+00 -2.2464e+00 -4.0201e+00 -9.3021e-01 -2.6983e-01 5.8463e+00 1.4303e-02 7.9043e-02 2.3395e-02 1.7339e-01 3.3846e-01 9.1334e-01 7.8046e-02 9.5881e-01 8.1223e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 51: 1.0022e+02 -4.0414e+00 -2.2373e+00 -4.0107e+00 -9.2183e-01 -2.6371e-01 5.8667e+00 1.8681e-02 7.5091e-02 2.2225e-02 1.6472e-01 3.7327e-01 9.4906e-01 8.0171e-02 1.0278e+00 8.7157e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 52: 1.0059e+02 -4.0444e+00 -2.2676e+00 -4.0263e+00 -9.1269e-01 -2.1748e-01 5.5734e+00 1.7747e-02 7.1337e-02 2.1114e-02 1.5648e-01 3.5461e-01 8.6417e-01 8.2918e-02 1.0332e+00 8.1690e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 53: 1.0071e+02 -4.0384e+00 -2.2530e+00 -4.0171e+00 -9.2997e-01 -2.5319e-01 5.2947e+00 1.6860e-02 6.7770e-02 2.0058e-02 1.6621e-01 3.3688e-01 8.9792e-01 7.8990e-02 1.0230e+00 7.9862e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 54: 1.0067e+02 -4.0271e+00 -2.2540e+00 -4.0251e+00 -9.2151e-01 -2.2197e-01 5.0300e+00 1.6017e-02 6.4381e-02 1.9055e-02 1.7025e-01 3.2003e-01 8.7999e-01 8.0187e-02 1.0487e+00 8.1091e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 55: 1.0083e+02 -4.0326e+00 -2.2090e+00 -4.0230e+00 -9.2078e-01 -2.4936e-01 4.8429e+00 1.5216e-02 6.1162e-02 1.8103e-02 1.7211e-01 3.0403e-01 8.8923e-01 8.2248e-02 1.0522e+00 8.0777e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 56: 1.0082e+02 -4.0284e+00 -2.2350e+00 -4.0083e+00 -8.9532e-01 -1.9565e-01 5.3306e+00 1.4455e-02 5.8104e-02 1.7197e-02 1.6350e-01 2.8883e-01 8.7438e-01 7.9530e-02 1.0748e+00 7.9892e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 57: 1.0089e+02 -4.0118e+00 -2.2585e+00 -3.9924e+00 -9.5279e-01 -2.7691e-01 5.4228e+00 1.3733e-02 5.5199e-02 1.6338e-02 1.9088e-01 2.7439e-01 9.3164e-01 8.0286e-02 1.1149e+00 8.3224e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 58: 1.0103e+02 -4.0117e+00 -2.2470e+00 -3.9628e+00 -9.5632e-01 -3.1385e-01 5.1517e+00 1.3046e-02 6.2482e-02 1.5521e-02 1.8744e-01 2.8144e-01 9.6857e-01 8.0586e-02 1.0149e+00 8.0615e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 59: 1.0110e+02 -4.0400e+00 -2.2319e+00 -3.9749e+00 -9.3280e-01 -3.1491e-01 4.8941e+00 1.4375e-02 7.6521e-02 1.9982e-02 1.8994e-01 2.6736e-01 9.9294e-01 7.6723e-02 9.8321e-01 8.4135e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 60: 1.0135e+02 -4.0401e+00 -2.2969e+00 -4.0006e+00 -9.3649e-01 -2.7105e-01 4.6494e+00 1.5352e-02 7.2695e-02 1.8983e-02 1.8339e-01 2.5400e-01 9.7671e-01 8.0731e-02 1.0344e+00 8.4798e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 61: 1.0139e+02 -4.0447e+00 -2.3267e+00 -4.0036e+00 -9.2609e-01 -2.4279e-01 4.4169e+00 1.4584e-02 6.9060e-02 1.8034e-02 1.7844e-01 2.4130e-01 9.4921e-01 8.1065e-02 1.0031e+00 8.2364e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 62: 1.0187e+02 -4.0605e+00 -2.2435e+00 -4.0093e+00 -9.4594e-01 -2.2911e-01 4.1961e+00 1.3855e-02 6.5607e-02 2.0229e-02 1.6951e-01 2.2923e-01 8.5507e-01 8.5043e-02 1.0003e+00 8.4881e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 63: 1.0181e+02 -4.0665e+00 -2.2106e+00 -3.9954e+00 -9.5259e-01 -2.2539e-01 3.9863e+00 1.3162e-02 6.2327e-02 1.9217e-02 2.0722e-01 2.1777e-01 9.2699e-01 7.9303e-02 9.8900e-01 8.5477e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 64: 1.0178e+02 -4.0641e+00 -2.2152e+00 -3.9904e+00 -9.7044e-01 -2.2671e-01 3.8289e+00 1.2504e-02 5.9210e-02 1.8256e-02 2.1010e-01 2.0688e-01 8.6741e-01 8.9748e-02 9.9564e-01 8.6675e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 65: 1.0149e+02 -4.0871e+00 -2.2063e+00 -4.0000e+00 -9.7253e-01 -2.0360e-01 3.6375e+00 1.1879e-02 5.8060e-02 1.7344e-02 2.3758e-01 1.9654e-01 9.1092e-01 8.6259e-02 1.0674e+00 8.6171e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 66: 1.0131e+02 -4.0863e+00 -2.2283e+00 -4.0026e+00 -9.6884e-01 -2.2153e-01 3.4556e+00 1.1285e-02 5.5157e-02 1.6476e-02 2.5128e-01 1.8671e-01 9.2512e-01 7.7687e-02 1.0847e+00 8.2689e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 67: 1.0124e+02 -4.0691e+00 -2.2261e+00 -4.0021e+00 -9.2647e-01 -2.9309e-01 3.2828e+00 1.0721e-02 5.2400e-02 1.5653e-02 2.3872e-01 1.7738e-01 8.3514e-01 8.7680e-02 1.0093e+00 8.1515e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 68: 1.0160e+02 -4.0653e+00 -2.2627e+00 -3.9685e+00 -9.5325e-01 -2.9870e-01 3.1187e+00 1.0185e-02 5.0455e-02 1.6013e-02 2.2678e-01 1.6851e-01 9.3016e-01 8.4873e-02 1.0357e+00 8.0066e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 69: 1.0154e+02 -4.0667e+00 -2.2536e+00 -3.9686e+00 -9.8329e-01 -2.1749e-01 2.9628e+00 9.6753e-03 4.7932e-02 1.6408e-02 2.1544e-01 1.6008e-01 9.4932e-01 8.5396e-02 1.0298e+00 8.2915e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 70: 1.0140e+02 -4.0718e+00 -2.2809e+00 -4.0031e+00 -9.7818e-01 -1.5912e-01 2.8146e+00 1.2376e-02 4.5536e-02 1.5606e-02 2.0467e-01 1.5208e-01 9.8171e-01 8.4966e-02 1.0881e+00 8.4583e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 71: 1.0119e+02 -4.0810e+00 -2.2832e+00 -3.9945e+00 -9.7859e-01 -1.6288e-01 2.6739e+00 1.1757e-02 4.3259e-02 2.2477e-02 1.9444e-01 1.4447e-01 9.2355e-01 8.4027e-02 1.0557e+00 8.3942e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 72: 1.0133e+02 -4.0904e+00 -2.2582e+00 -4.0034e+00 -1.0103e+00 -1.9818e-01 2.5402e+00 1.1169e-02 6.0710e-02 2.4943e-02 1.8472e-01 1.3725e-01 8.8530e-01 8.8313e-02 9.6043e-01 8.6565e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 73: 1.0081e+02 -4.0852e+00 -2.2408e+00 -4.0324e+00 -9.8147e-01 -2.0245e-01 2.4132e+00 1.0611e-02 6.0672e-02 2.3696e-02 1.7586e-01 1.5058e-01 9.8632e-01 8.0072e-02 1.0754e+00 8.4211e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 74: 1.0096e+02 -4.0784e+00 -2.2415e+00 -4.0085e+00 -9.6374e-01 -2.1820e-01 2.2925e+00 1.0080e-02 7.8175e-02 2.2511e-02 2.0451e-01 1.4305e-01 9.7218e-01 7.5856e-02 1.0703e+00 8.2684e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 75: 1.0059e+02 -4.0614e+00 -2.2571e+00 -4.0069e+00 -9.6858e-01 -2.2415e-01 2.1779e+00 9.5763e-03 7.4266e-02 2.1385e-02 2.0050e-01 1.3590e-01 9.4625e-01 8.3873e-02 1.0545e+00 8.0628e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 76: 1.0071e+02 -4.0570e+00 -2.2509e+00 -4.0111e+00 -9.4159e-01 -2.0936e-01 2.0690e+00 9.0975e-03 1.0546e-01 2.0316e-02 1.9048e-01 1.2911e-01 9.1139e-01 8.4290e-02 1.0164e+00 8.0587e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 77: 1.0056e+02 -4.0315e+00 -2.2434e+00 -4.0068e+00 -9.1913e-01 -2.0655e-01 1.9656e+00 8.6426e-03 1.2867e-01 1.9300e-02 1.8971e-01 1.5112e-01 9.1748e-01 8.0221e-02 1.0080e+00 8.2126e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 78: 1.0054e+02 -4.0350e+00 -2.2335e+00 -4.0109e+00 -9.4315e-01 -1.7472e-01 2.6310e+00 8.2105e-03 1.3206e-01 1.8867e-02 2.0835e-01 1.8443e-01 9.7893e-01 7.9595e-02 1.0622e+00 8.3669e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 79: 1.0036e+02 -4.0500e+00 -2.2739e+00 -4.0223e+00 -9.6070e-01 -1.8756e-01 2.5665e+00 7.7999e-03 1.2546e-01 1.7924e-02 1.9794e-01 2.0106e-01 9.4360e-01 8.0070e-02 1.0209e+00 8.4807e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 80: 1.0030e+02 -4.0522e+00 -2.2890e+00 -4.0149e+00 -9.2615e-01 -2.1233e-01 2.4382e+00 7.4099e-03 1.2570e-01 1.7028e-02 1.8804e-01 2.4730e-01 9.6559e-01 8.0105e-02 1.0382e+00 7.9028e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 81: 1.0004e+02 -4.0462e+00 -2.2766e+00 -4.0158e+00 -9.0841e-01 -2.3731e-01 3.0663e+00 7.0394e-03 1.2300e-01 1.6176e-02 1.7864e-01 2.3493e-01 8.8273e-01 8.0620e-02 1.0835e+00 7.9915e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 82: 1.0015e+02 -4.0106e+00 -2.2696e+00 -3.9845e+00 -9.2535e-01 -2.7387e-01 2.9130e+00 6.6875e-03 1.5058e-01 1.5368e-02 1.6971e-01 2.4826e-01 1.0039e+00 7.8035e-02 1.1181e+00 8.5136e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 83: 1.0019e+02 -4.0111e+00 -2.2266e+00 -3.9884e+00 -8.8579e-01 -2.3822e-01 2.7674e+00 6.3531e-03 1.9061e-01 1.4599e-02 1.6122e-01 2.3585e-01 1.0256e+00 8.1065e-02 1.0988e+00 8.4111e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 84: 99.9333 -4.0014 -2.2848 -3.9877 -0.8906 -0.2014 2.6290 0.0060 0.2388 0.0139 0.1532 0.2628 0.9936 0.0809 1.1059 0.0847</span> +<span class="r-out co"><span class="r-pr">#></span> 85: 99.6658 -4.0093 -2.2848 -3.9884 -0.8922 -0.2517 2.4976 0.0057 0.2269 0.0132 0.1455 0.2920 0.9705 0.0823 1.0458 0.0834</span> +<span class="r-out co"><span class="r-pr">#></span> 86: 99.8823 -4.0064 -2.2659 -4.0038 -0.9174 -0.1848 2.3727 0.0054 0.2155 0.0125 0.1382 0.2774 0.9699 0.0796 0.9808 0.0839</span> +<span class="r-out co"><span class="r-pr">#></span> 87: 1.0051e+02 -4.0156e+00 -2.2877e+00 -4.0160e+00 -8.9867e-01 -1.3463e-01 2.3477e+00 6.2688e-03 2.0474e-01 1.1891e-02 1.4859e-01 2.6352e-01 9.0742e-01 7.8361e-02 1.0082e+00 8.1020e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 88: 1.0036e+02 -4.0013e+00 -2.2738e+00 -4.0184e+00 -9.1589e-01 -1.4154e-01 3.0581e+00 7.7930e-03 2.5551e-01 1.1297e-02 1.4116e-01 2.5035e-01 9.8581e-01 7.6769e-02 9.7255e-01 8.8653e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 89: 1.0031e+02 -4.0155e+00 -2.3418e+00 -4.0080e+00 -8.8958e-01 -1.4006e-01 3.3754e+00 7.4891e-03 2.4274e-01 1.2919e-02 1.3411e-01 2.3783e-01 8.9921e-01 8.3685e-02 9.2657e-01 8.1804e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 90: 1.0044e+02 -4.0279e+00 -2.3328e+00 -4.0081e+00 -9.1868e-01 -1.3077e-01 3.6776e+00 1.1221e-02 2.3380e-01 1.2419e-02 1.4247e-01 2.2594e-01 8.8620e-01 8.0520e-02 9.0269e-01 8.2413e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 91: 1.0007e+02 -4.0329e+00 -2.3865e+00 -4.0145e+00 -8.9566e-01 -1.2400e-01 3.7450e+00 1.0660e-02 2.2211e-01 1.3667e-02 1.3534e-01 2.1539e-01 9.5638e-01 8.0235e-02 9.4346e-01 8.5828e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 92: 1.0025e+02 -4.0506e+00 -2.3252e+00 -4.0445e+00 -9.2023e-01 -5.6654e-02 3.9282e+00 1.0127e-02 2.4912e-01 1.2984e-02 1.4349e-01 2.6955e-01 9.6021e-01 7.7975e-02 9.1878e-01 8.6695e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 93: 1.0091e+02 -4.0566e+00 -2.2760e+00 -4.0422e+00 -9.2960e-01 -5.8179e-02 3.7318e+00 9.6210e-03 2.6385e-01 1.3422e-02 1.5136e-01 2.5607e-01 9.7012e-01 7.7323e-02 1.0157e+00 8.6123e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 94: 1.0045e+02 -4.0682e+00 -2.3163e+00 -4.0391e+00 -9.3398e-01 -1.0367e-01 4.0009e+00 9.1399e-03 2.5066e-01 1.2751e-02 1.6029e-01 2.9867e-01 9.1442e-01 8.0048e-02 9.7607e-01 8.5436e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 95: 1.0029e+02 -4.0790e+00 -2.2791e+00 -4.0470e+00 -9.4031e-01 -7.2610e-02 3.8008e+00 8.6829e-03 2.3813e-01 1.2114e-02 1.5227e-01 2.8373e-01 8.9105e-01 8.2168e-02 9.5542e-01 8.5308e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 96: 1.0017e+02 -4.0818e+00 -2.3204e+00 -4.0507e+00 -9.2181e-01 -7.5195e-02 3.6108e+00 8.2488e-03 2.2622e-01 1.1508e-02 1.5273e-01 2.6955e-01 9.3179e-01 7.7026e-02 1.0092e+00 8.4966e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 97: 1.0007e+02 -4.0721e+00 -2.3606e+00 -4.0453e+00 -9.4375e-01 -7.2811e-02 3.4303e+00 1.0904e-02 2.1585e-01 1.2641e-02 1.8282e-01 2.5788e-01 9.3750e-01 8.0427e-02 9.3193e-01 8.3262e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 98: 1.0024e+02 -4.1025e+00 -2.3916e+00 -4.0401e+00 -9.6711e-01 -6.7764e-02 3.2587e+00 1.0359e-02 2.0506e-01 1.8712e-02 1.9260e-01 2.4499e-01 1.0086e+00 7.7282e-02 9.6010e-01 8.1760e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 99: 1.0024e+02 -4.0755e+00 -2.3237e+00 -4.0581e+00 -9.5543e-01 -8.1716e-02 3.0958e+00 9.8408e-03 1.9481e-01 1.7973e-02 1.8297e-01 2.5653e-01 8.6589e-01 7.7940e-02 9.2919e-01 8.4396e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 100: 1.0039e+02 -4.0828e+00 -2.2976e+00 -4.0616e+00 -9.8223e-01 -8.5593e-02 3.9873e+00 9.3488e-03 1.8507e-01 1.8837e-02 1.7382e-01 2.4370e-01 8.6471e-01 8.4021e-02 9.4587e-01 8.1697e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 101: 1.0089e+02 -4.0738e+00 -2.3406e+00 -4.0465e+00 -9.4824e-01 -4.4055e-02 5.2624e+00 8.8814e-03 1.8051e-01 1.7896e-02 1.6513e-01 2.3288e-01 8.4179e-01 8.2487e-02 8.8097e-01 8.1625e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 102: 1.0090e+02 -4.0777e+00 -2.3244e+00 -4.0500e+00 -9.4069e-01 -5.2554e-02 5.5339e+00 8.4373e-03 1.7148e-01 1.7001e-02 1.5688e-01 2.2124e-01 9.0419e-01 7.8446e-02 9.4721e-01 8.0896e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 103: 1.0067e+02 -4.0658e+00 -2.3188e+00 -4.0312e+00 -9.5981e-01 -7.3735e-02 7.0281e+00 8.0154e-03 1.6291e-01 1.6151e-02 1.7019e-01 2.1018e-01 9.3631e-01 8.1516e-02 9.8773e-01 8.0587e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 104: 1.0015e+02 -4.0729e+00 -2.3830e+00 -4.0458e+00 -9.4446e-01 -5.0075e-02 6.6767e+00 7.6147e-03 1.5476e-01 1.5343e-02 1.6822e-01 1.9967e-01 8.2373e-01 8.3029e-02 9.6909e-01 7.9505e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 105: 1.0022e+02 -4.0888e+00 -2.3301e+00 -4.0411e+00 -9.5279e-01 -1.1412e-01 6.3429e+00 7.2339e-03 1.4702e-01 1.4576e-02 1.8886e-01 2.2088e-01 9.2925e-01 7.3020e-02 1.0450e+00 8.6511e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 106: 1.0013e+02 -4.0846e+00 -2.3428e+00 -4.0530e+00 -9.1649e-01 -8.1899e-02 6.0257e+00 6.8722e-03 1.3967e-01 1.8939e-02 1.8350e-01 2.1970e-01 9.4571e-01 8.6259e-02 8.8509e-01 8.1023e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 107: 1.0026e+02 -4.0954e+00 -2.3362e+00 -4.0586e+00 -9.6302e-01 -8.0898e-03 5.7244e+00 6.5286e-03 1.3269e-01 2.2595e-02 2.0043e-01 2.4151e-01 8.8882e-01 8.8155e-02 8.2466e-01 8.5467e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 108: 1.0109e+02 -4.0796e+00 -2.3980e+00 -4.0841e+00 -9.5525e-01 2.0583e-02 5.4382e+00 6.2022e-03 1.2606e-01 3.4423e-02 2.2509e-01 2.3732e-01 9.0211e-01 8.1331e-02 9.2728e-01 8.4409e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 109: 1.0091e+02 -4.0872e+00 -2.3614e+00 -4.0620e+00 -9.5950e-01 -1.8283e-02 5.1663e+00 6.1750e-03 1.1975e-01 3.2702e-02 2.1384e-01 2.2546e-01 9.7296e-01 7.7298e-02 9.7366e-01 8.3784e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 110: 1.0137e+02 -4.0637e+00 -2.3734e+00 -4.0781e+00 -9.3874e-01 -6.0140e-03 4.9080e+00 6.5148e-03 1.1376e-01 3.1066e-02 2.0314e-01 2.3943e-01 9.2451e-01 8.4473e-02 9.7311e-01 8.4958e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 111: 1.0181e+02 -4.0588e+00 -2.3200e+00 -4.0792e+00 -9.9395e-01 -3.1776e-02 4.6626e+00 9.9112e-03 1.0808e-01 4.1755e-02 1.9299e-01 2.9896e-01 1.0697e+00 7.1561e-02 1.0062e+00 8.8034e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 112: 1.0222e+02 -4.0566e+00 -2.3525e+00 -4.0607e+00 -9.6055e-01 -6.3691e-02 4.4850e+00 9.4157e-03 1.0267e-01 4.0540e-02 1.8334e-01 3.5699e-01 1.0213e+00 7.5944e-02 1.0070e+00 8.3434e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 113: 1.0189e+02 -4.0478e+00 -2.3774e+00 -4.0434e+00 -9.6638e-01 -6.7729e-02 5.1753e+00 8.9449e-03 9.7539e-02 3.8513e-02 2.0339e-01 3.4044e-01 9.5484e-01 7.7854e-02 9.8545e-01 8.1852e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 114: 1.0225e+02 -4.0334e+00 -2.3728e+00 -4.0502e+00 -9.4795e-01 -7.3569e-02 4.9165e+00 8.8152e-03 9.2662e-02 3.7310e-02 2.0002e-01 3.2342e-01 9.3586e-01 8.1063e-02 9.5652e-01 8.3067e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 115: 1.0196e+02 -4.0302e+00 -2.3599e+00 -4.0812e+00 -9.6783e-01 7.1536e-03 4.8473e+00 9.4780e-03 1.0791e-01 3.7184e-02 1.9002e-01 3.0725e-01 9.1488e-01 7.6079e-02 1.0104e+00 8.7136e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 116: 1.0150e+02 -4.0420e+00 -2.3637e+00 -4.0535e+00 -9.4545e-01 -7.6387e-02 4.6049e+00 9.6408e-03 1.0251e-01 3.8115e-02 1.8052e-01 2.9189e-01 9.0583e-01 8.2597e-02 9.5680e-01 8.1246e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 117: 1.0161e+02 -4.0606e+00 -2.3853e+00 -4.0750e+00 -9.7273e-01 -2.7338e-03 4.3747e+00 9.1587e-03 9.7386e-02 3.7863e-02 1.8701e-01 2.7729e-01 8.4511e-01 8.4164e-02 9.4149e-01 8.0525e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 118: 1.0174e+02 -4.0727e+00 -2.3776e+00 -4.0850e+00 -9.6982e-01 -1.2188e-03 4.1560e+00 8.7008e-03 9.2516e-02 4.9300e-02 2.1364e-01 2.6343e-01 9.5447e-01 8.6627e-02 9.1835e-01 8.1284e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 119: 1.0141e+02 -4.0887e+00 -2.3138e+00 -4.0772e+00 -9.9409e-01 -5.0120e-02 3.9482e+00 8.2658e-03 8.7891e-02 4.6835e-02 2.5364e-01 2.5026e-01 9.4576e-01 8.4355e-02 9.5762e-01 8.5430e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 120: 1.0116e+02 -4.1014e+00 -2.3328e+00 -4.0418e+00 -9.7139e-01 -8.9664e-02 3.7508e+00 7.8525e-03 8.3496e-02 4.4493e-02 2.4096e-01 2.3774e-01 9.2816e-01 8.5558e-02 9.7817e-01 8.5169e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 121: 1.0099e+02 -4.0876e+00 -2.3277e+00 -4.0746e+00 -9.5453e-01 -2.6752e-02 3.5632e+00 7.4598e-03 7.9321e-02 4.2269e-02 2.2891e-01 2.2586e-01 8.9613e-01 8.0488e-02 9.7590e-01 8.4798e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 122: 1.0171e+02 -4.0620e+00 -2.3349e+00 -4.0659e+00 -9.4420e-01 -1.6907e-02 3.3851e+00 7.0869e-03 8.8424e-02 4.0155e-02 2.1747e-01 2.1456e-01 9.0159e-01 7.8017e-02 9.8579e-01 8.4585e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 123: 1.0191e+02 -4.0708e+00 -2.3487e+00 -4.0827e+00 -9.5025e-01 -5.7459e-03 3.2158e+00 6.7325e-03 1.0499e-01 3.8147e-02 2.0659e-01 2.0384e-01 9.6378e-01 7.4758e-02 9.6268e-01 8.4712e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 124: 1.0224e+02 -4.0798e+00 -2.2989e+00 -4.0724e+00 -9.8452e-01 -3.1802e-02 3.0550e+00 6.3959e-03 9.9739e-02 3.6240e-02 1.9626e-01 1.9364e-01 9.4424e-01 7.4219e-02 9.9842e-01 8.4793e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 125: 1.0242e+02 -4.0710e+00 -2.3242e+00 -4.0661e+00 -1.0094e+00 -2.9970e-02 2.9023e+00 6.0761e-03 9.4752e-02 3.6130e-02 1.8645e-01 1.8396e-01 9.2576e-01 8.0533e-02 9.9407e-01 8.1660e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 126: 1.0254e+02 -4.0685e+00 -2.3356e+00 -4.0599e+00 -1.0031e+00 4.0250e-03 2.7571e+00 5.7723e-03 1.0658e-01 3.4324e-02 1.7971e-01 1.7476e-01 9.4870e-01 7.4027e-02 9.2757e-01 8.3091e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 127: 1.0270e+02 -4.0492e+00 -2.3174e+00 -4.0476e+00 -9.9898e-01 -6.3197e-02 2.6193e+00 5.4837e-03 1.0746e-01 3.2607e-02 1.7072e-01 1.6603e-01 9.0721e-01 7.7941e-02 9.4624e-01 8.1077e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 128: 1.0284e+02 -4.0582e+00 -2.2991e+00 -4.0331e+00 -9.9114e-01 -5.6800e-02 2.4883e+00 5.2095e-03 1.2321e-01 3.1304e-02 1.6219e-01 1.5772e-01 8.7403e-01 8.4147e-02 8.9187e-01 8.5089e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 129: 1.0275e+02 -4.0773e+00 -2.2935e+00 -4.0389e+00 -9.9661e-01 -7.4747e-02 2.3639e+00 4.9922e-03 1.1705e-01 2.9738e-02 1.9667e-01 1.4984e-01 9.1481e-01 8.4947e-02 9.3224e-01 8.5270e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 130: 1.0222e+02 -4.0835e+00 -2.3177e+00 -4.0343e+00 -1.0044e+00 -7.6530e-02 2.2457e+00 4.7426e-03 1.1120e-01 3.1348e-02 2.0663e-01 1.4235e-01 1.0173e+00 7.4769e-02 9.9905e-01 8.6058e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 131: 1.0202e+02 -4.0767e+00 -2.2497e+00 -4.0270e+00 -1.0015e+00 -1.4868e-01 2.1334e+00 5.5790e-03 1.0564e-01 2.9781e-02 2.1254e-01 1.3523e-01 1.0223e+00 7.7587e-02 9.4151e-01 8.4206e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 132: 1.0191e+02 -4.0756e+00 -2.2363e+00 -4.0081e+00 -9.7264e-01 -2.0991e-01 2.0268e+00 5.3000e-03 1.0184e-01 2.8291e-02 2.0191e-01 1.7667e-01 9.2404e-01 7.9813e-02 9.2266e-01 8.6307e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 133: 1.0187e+02 -4.0743e+00 -2.1951e+00 -4.0196e+00 -9.7534e-01 -1.8742e-01 1.9254e+00 5.0350e-03 9.6744e-02 2.6877e-02 1.9181e-01 1.6784e-01 1.0007e+00 8.2043e-02 1.0028e+00 8.3921e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 134: 1.0182e+02 -4.0731e+00 -2.2321e+00 -4.0041e+00 -9.2800e-01 -1.4985e-01 1.8291e+00 4.7833e-03 9.1906e-02 2.7751e-02 1.8222e-01 1.6415e-01 9.7093e-01 7.5558e-02 9.8455e-01 8.4921e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 135: 1.0188e+02 -4.0724e+00 -2.2774e+00 -4.0213e+00 -9.3930e-01 -1.7385e-01 1.7377e+00 4.5441e-03 8.7311e-02 2.6363e-02 1.7311e-01 1.5594e-01 9.4053e-01 8.3922e-02 9.8689e-01 8.1203e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 136: 1.0202e+02 -4.0712e+00 -2.2711e+00 -4.0128e+00 -9.8747e-01 -1.3610e-01 1.6508e+00 4.3169e-03 1.0383e-01 2.5045e-02 1.8004e-01 1.4814e-01 9.6497e-01 8.1397e-02 1.0782e+00 8.2539e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 137: 1.0228e+02 -4.0676e+00 -2.2403e+00 -4.0069e+00 -9.7761e-01 -1.5314e-01 1.5683e+00 4.1011e-03 1.0931e-01 2.4722e-02 1.8328e-01 1.4074e-01 9.8300e-01 7.5906e-02 1.0221e+00 8.2306e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 138: 1.0229e+02 -4.0654e+00 -2.2510e+00 -3.9908e+00 -1.0400e+00 -1.4173e-01 1.4899e+00 4.2166e-03 1.3448e-01 2.3486e-02 1.8272e-01 1.3370e-01 1.0305e+00 8.0580e-02 1.0988e+00 8.3512e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 139: 1.0258e+02 -4.0599e+00 -2.2207e+00 -3.9622e+00 -1.0058e+00 -2.6676e-01 1.4154e+00 4.0057e-03 1.5190e-01 2.2312e-02 1.7359e-01 1.2702e-01 9.6425e-01 8.6887e-02 1.0373e+00 8.3853e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 140: 1.0224e+02 -4.0665e+00 -2.2479e+00 -4.0063e+00 -1.0054e+00 -1.6109e-01 1.3446e+00 3.8054e-03 1.4430e-01 2.4389e-02 1.6697e-01 1.2066e-01 9.9245e-01 8.3900e-02 1.1218e+00 8.2527e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 141: 1.0245e+02 -4.0843e+00 -2.2024e+00 -3.9657e+00 -1.0057e+00 -2.4900e-01 1.2774e+00 3.6152e-03 1.3709e-01 2.3170e-02 1.8559e-01 1.1463e-01 9.4091e-01 8.7616e-02 1.0760e+00 8.1871e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 142: 1.0253e+02 -4.0972e+00 -2.1943e+00 -3.9649e+00 -1.0160e+00 -2.9535e-01 1.2135e+00 3.4344e-03 1.6892e-01 2.2011e-02 1.7631e-01 1.0890e-01 9.2146e-01 9.0207e-02 1.0645e+00 8.5078e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 143: 1.0252e+02 -4.1005e+00 -2.1652e+00 -3.9687e+00 -1.0445e+00 -2.4274e-01 2.0559e+00 3.9136e-03 1.6047e-01 2.0911e-02 1.6750e-01 1.0345e-01 9.0785e-01 8.5522e-02 1.1734e+00 8.5544e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 144: 1.0257e+02 -4.1199e+00 -2.1994e+00 -3.9618e+00 -1.0480e+00 -2.0099e-01 1.9531e+00 4.2739e-03 1.5745e-01 1.9865e-02 1.6053e-01 9.8282e-02 9.3710e-01 8.5496e-02 1.0597e+00 8.4335e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 145: 1.0282e+02 -4.1356e+00 -2.1489e+00 -3.9708e+00 -1.0268e+00 -2.2250e-01 1.8554e+00 4.0602e-03 1.7177e-01 1.8872e-02 1.5251e-01 9.3368e-02 9.5312e-01 8.3609e-02 1.0695e+00 8.3492e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 146: 1.0282e+02 -4.1443e+00 -2.2103e+00 -3.9821e+00 -1.0080e+00 -2.2414e-01 1.7627e+00 4.0693e-03 1.6460e-01 1.7928e-02 1.5576e-01 8.8699e-02 9.8656e-01 8.4549e-02 1.0251e+00 7.9572e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 147: 1.0295e+02 -4.1363e+00 -2.1920e+00 -3.9828e+00 -1.0567e+00 -1.9047e-01 1.6745e+00 3.8659e-03 1.6104e-01 1.7032e-02 1.6551e-01 8.4264e-02 9.4144e-01 8.7085e-02 1.0623e+00 8.1949e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 148: 1.0299e+02 -4.1336e+00 -2.1967e+00 -3.9921e+00 -1.0425e+00 -1.7466e-01 1.7992e+00 3.6726e-03 1.5298e-01 1.9937e-02 1.9453e-01 8.0051e-02 9.9498e-01 8.3001e-02 1.0884e+00 8.1599e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 149: 1.0292e+02 -4.1282e+00 -2.2741e+00 -4.0028e+00 -1.0650e+00 -1.4879e-01 2.1425e+00 3.4890e-03 1.4534e-01 1.8941e-02 2.0240e-01 7.6049e-02 1.0080e+00 7.9550e-02 1.1679e+00 7.9115e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 150: 1.0302e+02 -4.1402e+00 -2.2769e+00 -4.0056e+00 -1.0488e+00 -1.2845e-01 2.7814e+00 3.3145e-03 1.3807e-01 2.0220e-02 1.9228e-01 7.2246e-02 9.9253e-01 8.0215e-02 1.0075e+00 8.2295e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 151: 1.0304e+02 -4.1281e+00 -2.2250e+00 -4.0169e+00 -1.0448e+00 -1.4468e-01 2.6423e+00 3.1488e-03 1.3117e-01 2.1298e-02 1.8267e-01 6.8634e-02 1.0207e+00 8.0317e-02 1.0813e+00 8.5492e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 152: 1.0321e+02 -4.1291e+00 -2.2281e+00 -4.0180e+00 -1.0232e+00 -1.4990e-01 1.6327e+00 2.8585e-03 1.0498e-01 1.8944e-02 1.6146e-01 5.0784e-02 9.5663e-01 7.9113e-02 1.1344e+00 8.2687e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 153: 1.0309e+02 -4.1280e+00 -2.2030e+00 -4.0149e+00 -1.0198e+00 -1.3442e-01 1.6757e+00 3.4142e-03 9.0693e-02 2.2471e-02 1.6167e-01 3.6279e-02 9.6659e-01 8.1655e-02 1.0345e+00 8.6113e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 154: 1.0298e+02 -4.1506e+00 -2.2176e+00 -3.9851e+00 -1.0417e+00 -1.6429e-01 1.9656e+00 3.3408e-03 9.5697e-02 2.1721e-02 1.6754e-01 2.9142e-02 1.0379e+00 7.9957e-02 1.0132e+00 8.5327e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 155: 1.0328e+02 -4.1204e+00 -2.2287e+00 -3.9772e+00 -1.0135e+00 -2.0459e-01 1.9195e+00 3.3987e-03 1.0293e-01 1.6897e-02 1.9470e-01 2.0826e-02 9.4310e-01 8.0528e-02 1.0639e+00 8.1926e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 156: 1.0338e+02 -4.1272e+00 -2.1962e+00 -3.9743e+00 -1.0491e+00 -1.8971e-01 1.7194e+00 3.2287e-03 7.8468e-02 1.8220e-02 1.8015e-01 2.0956e-02 9.2992e-01 8.6295e-02 9.5939e-01 8.1945e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 157: 1.0331e+02 -4.1188e+00 -2.1783e+00 -3.9779e+00 -1.0506e+00 -1.9810e-01 1.1127e+00 2.7176e-03 6.1234e-02 1.3748e-02 2.0147e-01 3.4800e-02 9.3006e-01 8.4794e-02 1.0579e+00 8.1604e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 158: 1.0326e+02 -4.1162e+00 -2.1734e+00 -3.9827e+00 -1.0632e+00 -2.0171e-01 1.3289e+00 2.7407e-03 7.1465e-02 1.2306e-02 2.1511e-01 3.4923e-02 8.9200e-01 8.4554e-02 1.1179e+00 8.2301e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 159: 1.0358e+02 -4.1075e+00 -2.2069e+00 -3.9725e+00 -1.0445e+00 -1.8044e-01 1.6656e+00 2.5282e-03 6.4340e-02 1.3587e-02 2.0355e-01 2.7629e-02 8.9557e-01 8.3727e-02 1.0560e+00 8.0934e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 160: 1.0364e+02 -4.1182e+00 -2.1514e+00 -3.9750e+00 -1.0378e+00 -2.2449e-01 1.8413e+00 3.5609e-03 7.2072e-02 1.5648e-02 2.0999e-01 3.1283e-02 9.1468e-01 8.2340e-02 1.0016e+00 8.0955e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 161: 1.0387e+02 -4.0964e+00 -2.1926e+00 -3.9808e+00 -1.0397e+00 -2.5178e-01 2.3706e+00 2.4158e-03 7.4658e-02 1.7789e-02 1.8587e-01 3.1647e-02 8.8257e-01 8.4503e-02 9.5909e-01 8.2216e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 162: 1.0399e+02 -4.0992e+00 -2.2056e+00 -3.9647e+00 -1.0388e+00 -2.4824e-01 1.9736e+00 2.2302e-03 1.0445e-01 1.9729e-02 1.9531e-01 2.9879e-02 8.3560e-01 8.6622e-02 9.5407e-01 7.9625e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 163: 1.0366e+02 -4.0956e+00 -2.1684e+00 -3.9612e+00 -1.0058e+00 -2.6882e-01 2.5872e+00 1.6246e-03 8.1892e-02 2.2777e-02 2.2429e-01 2.8371e-02 8.4799e-01 9.0947e-02 9.5842e-01 8.2649e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 164: 1.0325e+02 -4.0878e+00 -2.1946e+00 -3.9781e+00 -9.8890e-01 -2.6917e-01 2.0805e+00 1.3401e-03 8.2477e-02 2.6550e-02 1.8386e-01 2.4255e-02 8.5728e-01 8.9778e-02 9.1439e-01 7.9784e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 165: 1.0282e+02 -4.0801e+00 -2.1928e+00 -3.9664e+00 -9.9558e-01 -2.6059e-01 1.4087e+00 1.2155e-03 5.8081e-02 2.3833e-02 2.1871e-01 2.0911e-02 8.6998e-01 8.9895e-02 9.9363e-01 8.0284e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 166: 1.0285e+02 -4.0942e+00 -2.1855e+00 -3.9889e+00 -1.0234e+00 -2.4125e-01 8.5034e-01 6.8919e-04 6.5725e-02 2.3045e-02 2.1221e-01 2.6083e-02 8.7024e-01 9.4598e-02 9.5824e-01 8.3361e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 167: 1.0267e+02 -4.0904e+00 -2.2131e+00 -3.9917e+00 -9.9055e-01 -2.1449e-01 9.1382e-01 4.6145e-04 8.1337e-02 2.2154e-02 2.1431e-01 2.7524e-02 8.4730e-01 8.3563e-02 9.9458e-01 8.0138e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 168: 1.0249e+02 -4.0954e+00 -2.2174e+00 -3.9868e+00 -9.9799e-01 -1.8848e-01 6.5737e-01 4.2757e-04 6.9428e-02 2.8833e-02 2.0256e-01 4.1573e-02 9.8269e-01 7.6264e-02 1.0011e+00 8.1357e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 169: 1.0252e+02 -4.0995e+00 -2.2132e+00 -3.9792e+00 -9.8661e-01 -2.2724e-01 5.4553e-01 3.9691e-04 4.2460e-02 2.7545e-02 2.2594e-01 4.9079e-02 9.6027e-01 8.1006e-02 1.0261e+00 8.5194e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 170: 1.0246e+02 -4.1056e+00 -2.2389e+00 -3.9785e+00 -1.0354e+00 -2.4212e-01 4.5653e-01 2.8583e-04 2.8936e-02 2.5026e-02 1.8496e-01 4.3514e-02 9.2689e-01 9.6050e-02 9.9096e-01 8.3466e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 171: 1.0238e+02 -4.1027e+00 -2.2592e+00 -3.9859e+00 -1.0106e+00 -2.3962e-01 5.1080e-01 2.6715e-04 3.2138e-02 2.7859e-02 1.6505e-01 6.2560e-02 9.1886e-01 9.0993e-02 9.4634e-01 8.3542e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 172: 1.0242e+02 -4.0998e+00 -2.2415e+00 -3.9999e+00 -1.0234e+00 -2.2610e-01 5.1154e-01 1.8668e-04 2.2768e-02 2.9930e-02 2.0056e-01 7.5570e-02 9.4948e-01 8.4742e-02 9.1357e-01 8.3596e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 173: 1.0232e+02 -4.1005e+00 -2.2382e+00 -4.0022e+00 -1.0017e+00 -1.8406e-01 3.2169e-01 2.0484e-04 2.4102e-02 2.9249e-02 2.0445e-01 1.1517e-01 9.5169e-01 8.3951e-02 9.0402e-01 8.3130e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 174: 1.0233e+02 -4.0990e+00 -2.2337e+00 -3.9975e+00 -1.0298e+00 -1.8028e-01 4.2668e-01 2.1409e-04 2.4350e-02 2.4159e-02 2.0114e-01 1.4344e-01 9.3446e-01 8.6704e-02 9.6511e-01 8.3994e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 175: 1.0236e+02 -4.0991e+00 -2.2315e+00 -3.9883e+00 -1.0110e+00 -2.2190e-01 4.1564e-01 2.5844e-04 3.5664e-02 2.1844e-02 2.0315e-01 1.2876e-01 8.9006e-01 8.3016e-02 9.2369e-01 8.0410e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 176: 1.0222e+02 -4.0983e+00 -2.1991e+00 -3.9924e+00 -1.0148e+00 -2.3133e-01 1.7684e-01 2.5312e-04 5.3516e-02 2.2568e-02 2.0010e-01 1.0721e-01 8.9884e-01 7.6042e-02 1.0110e+00 7.9890e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 177: 1.0219e+02 -4.1022e+00 -2.2129e+00 -3.9804e+00 -1.0286e+00 -1.9916e-01 1.9962e-01 3.0338e-04 6.9476e-02 2.0133e-02 1.8707e-01 1.0631e-01 8.7419e-01 8.3199e-02 9.5450e-01 8.2626e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 178: 1.0225e+02 -4.1022e+00 -2.2135e+00 -4.0057e+00 -1.0264e+00 -2.2859e-01 2.1742e-01 2.9489e-04 5.1238e-02 2.2227e-02 1.7924e-01 1.4496e-01 8.5487e-01 8.3885e-02 9.7315e-01 8.1406e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 179: 1.0234e+02 -4.1015e+00 -2.2170e+00 -3.9999e+00 -1.0177e+00 -2.0895e-01 2.1196e-01 3.0802e-04 5.7417e-02 2.6776e-02 1.7214e-01 1.5197e-01 8.8641e-01 7.7789e-02 9.2725e-01 8.1277e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 180: 1.0243e+02 -4.1034e+00 -2.2337e+00 -4.0000e+00 -1.0018e+00 -2.3492e-01 2.0521e-01 3.1261e-04 6.0162e-02 2.7277e-02 1.7524e-01 1.6673e-01 8.8472e-01 7.8939e-02 9.1311e-01 8.3794e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 181: 1.0244e+02 -4.1031e+00 -2.2415e+00 -3.9951e+00 -9.9356e-01 -1.9938e-01 1.4850e-01 2.7894e-04 5.5244e-02 3.2404e-02 2.0701e-01 2.1022e-01 8.7495e-01 8.1883e-02 9.7574e-01 8.4575e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 182: 1.0245e+02 -4.1066e+00 -2.2849e+00 -4.0083e+00 -1.0260e+00 -1.9418e-01 1.0783e-01 1.7359e-04 2.9632e-02 3.2098e-02 2.0294e-01 1.7919e-01 9.0795e-01 9.1179e-02 9.8651e-01 8.3561e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 183: 1.0248e+02 -4.1066e+00 -2.2844e+00 -4.0201e+00 -1.0102e+00 -1.5510e-01 9.2727e-02 1.4337e-04 2.8436e-02 4.3941e-02 1.9683e-01 2.1943e-01 9.0334e-01 8.2113e-02 8.9037e-01 8.4506e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 184: 1.0239e+02 -4.1032e+00 -2.2726e+00 -4.0270e+00 -1.0162e+00 -1.4921e-01 9.0062e-02 1.0820e-04 3.5099e-02 4.7338e-02 1.8488e-01 2.2174e-01 9.1525e-01 7.9986e-02 8.6762e-01 8.4376e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 185: 1.0240e+02 -4.1028e+00 -2.3201e+00 -4.0248e+00 -9.8758e-01 -1.7235e-01 9.2455e-02 8.9653e-05 4.7097e-02 4.5964e-02 1.9093e-01 1.9093e-01 9.5192e-01 7.6980e-02 9.4058e-01 8.2740e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 186: 1.0250e+02 -4.1020e+00 -2.3095e+00 -4.0326e+00 -9.9767e-01 -1.2041e-01 1.0792e-01 7.3472e-05 3.6352e-02 4.6680e-02 1.7527e-01 1.7411e-01 9.6831e-01 8.3088e-02 9.7978e-01 8.1096e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 187: 1.0254e+02 -4.1022e+00 -2.3078e+00 -4.0329e+00 -1.0166e+00 -1.1644e-01 8.2987e-02 7.9222e-05 3.8388e-02 6.0452e-02 2.3498e-01 1.7389e-01 1.0450e+00 8.0354e-02 9.7366e-01 8.2504e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 188: 1.0253e+02 -4.1022e+00 -2.3172e+00 -4.0401e+00 -1.0276e+00 -8.2442e-02 8.3913e-02 7.1884e-05 4.3025e-02 4.8383e-02 1.9392e-01 1.6073e-01 9.7466e-01 7.5977e-02 9.0319e-01 8.4648e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 189: 1.0256e+02 -4.1013e+00 -2.3037e+00 -4.0402e+00 -1.0004e+00 -1.5946e-01 9.6273e-02 8.0773e-05 4.6130e-02 5.2356e-02 2.1044e-01 2.0403e-01 9.2931e-01 8.2686e-02 9.0103e-01 8.5442e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 190: 1.0245e+02 -4.1021e+00 -2.3143e+00 -4.0314e+00 -9.9314e-01 -8.5545e-02 8.0660e-02 7.3369e-05 4.1713e-02 4.4940e-02 1.7715e-01 1.6886e-01 9.7982e-01 8.1720e-02 8.9868e-01 8.4964e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 191: 1.0251e+02 -4.1021e+00 -2.2849e+00 -4.0229e+00 -1.0346e+00 -9.0261e-02 6.1956e-02 9.4824e-05 5.8037e-02 4.0685e-02 1.8455e-01 2.2838e-01 9.9679e-01 7.7457e-02 9.4591e-01 8.5446e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 192: 1.0249e+02 -4.1012e+00 -2.2915e+00 -4.0452e+00 -1.0323e+00 -1.1123e-01 5.1409e-02 1.1452e-04 7.2457e-02 3.6376e-02 1.6706e-01 2.1050e-01 8.7970e-01 8.6881e-02 9.2230e-01 8.6563e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 193: 1.0249e+02 -4.1011e+00 -2.3104e+00 -4.0569e+00 -1.0032e+00 -2.9383e-02 4.2462e-02 9.6872e-05 4.9405e-02 4.6840e-02 1.7348e-01 1.4473e-01 9.1758e-01 8.1380e-02 1.0057e+00 8.4481e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 194: 1.0250e+02 -4.1009e+00 -2.2960e+00 -4.0567e+00 -9.9145e-01 -1.0640e-01 2.6698e-02 5.3298e-05 4.3880e-02 5.1866e-02 2.0619e-01 1.4008e-01 9.8306e-01 8.0320e-02 9.8405e-01 8.0106e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 195: 1.0252e+02 -4.1001e+00 -2.2779e+00 -4.0677e+00 -9.9960e-01 -5.5605e-02 1.9114e-02 5.6472e-05 4.5810e-02 5.1552e-02 1.8363e-01 1.2037e-01 9.9334e-01 8.2093e-02 9.9128e-01 8.3930e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 196: 1.0251e+02 -4.0988e+00 -2.2515e+00 -4.0555e+00 -9.9701e-01 -1.0235e-01 1.3362e-02 3.2648e-05 4.0337e-02 4.4117e-02 1.9469e-01 1.2907e-01 9.1150e-01 8.5071e-02 9.7929e-01 8.2761e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 197: 1.0253e+02 -4.0985e+00 -2.2589e+00 -4.0427e+00 -1.0251e+00 -9.4695e-02 1.7104e-02 2.3125e-05 4.1773e-02 3.3831e-02 2.1013e-01 1.3727e-01 9.1462e-01 8.1836e-02 9.7695e-01 8.1326e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 198: 1.0253e+02 -4.0992e+00 -2.2745e+00 -4.0327e+00 -9.8743e-01 -1.4108e-01 9.3331e-03 2.3064e-05 3.7271e-02 2.7379e-02 2.1190e-01 9.3733e-02 9.0916e-01 8.4247e-02 9.8720e-01 7.7405e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 199: 1.0251e+02 -4.0981e+00 -2.2770e+00 -4.0275e+00 -1.0216e+00 -1.3364e-01 8.3776e-03 2.3195e-05 4.6827e-02 3.2861e-02 1.9817e-01 8.7748e-02 9.1184e-01 8.3773e-02 9.5209e-01 7.9056e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 200: 1.0252e+02 -4.0992e+00 -2.2757e+00 -4.0277e+00 -9.9266e-01 -8.4583e-02 6.8073e-03 2.9414e-05 5.3404e-02 2.5942e-02 1.9915e-01 7.4937e-02 8.7168e-01 8.5197e-02 9.3606e-01 8.0739e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 201: 1.0252e+02 -4.0989e+00 -2.2706e+00 -4.0333e+00 -9.8978e-01 -8.7996e-02 5.9272e-03 2.4268e-05 5.4295e-02 2.9276e-02 2.0543e-01 7.1533e-02 9.0557e-01 8.3204e-02 9.4913e-01 8.0398e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 202: 1.0251e+02 -4.0990e+00 -2.2661e+00 -4.0324e+00 -9.8785e-01 -9.8008e-02 5.7831e-03 2.1967e-05 5.7627e-02 3.0606e-02 2.1414e-01 6.9475e-02 9.2255e-01 8.2143e-02 9.5633e-01 8.1333e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 203: 1.0251e+02 -4.0992e+00 -2.2586e+00 -4.0297e+00 -9.9017e-01 -1.1012e-01 6.4046e-03 2.2234e-05 5.7955e-02 3.0102e-02 2.0473e-01 6.8225e-02 9.2900e-01 8.3228e-02 9.5862e-01 8.1460e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 204: 1.0251e+02 -4.0995e+00 -2.2570e+00 -4.0280e+00 -9.9135e-01 -1.0718e-01 6.5386e-03 2.2043e-05 5.6949e-02 2.9096e-02 2.0562e-01 6.8687e-02 9.3306e-01 8.2703e-02 9.6581e-01 8.1671e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 205: 1.0250e+02 -4.0997e+00 -2.2569e+00 -4.0256e+00 -9.9350e-01 -1.1491e-01 6.1521e-03 2.2570e-05 5.5450e-02 2.8152e-02 2.0423e-01 7.2820e-02 9.2469e-01 8.3272e-02 9.7372e-01 8.0814e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 206: 1.0250e+02 -4.0997e+00 -2.2567e+00 -4.0269e+00 -9.9869e-01 -1.1438e-01 5.9720e-03 2.3307e-05 5.5103e-02 2.8506e-02 2.0414e-01 7.8225e-02 9.2768e-01 8.3328e-02 9.8294e-01 8.0918e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 207: 1.0250e+02 -4.0998e+00 -2.2657e+00 -4.0311e+00 -1.0000e+00 -1.0595e-01 6.0030e-03 2.4031e-05 5.4378e-02 2.9468e-02 2.0222e-01 8.1455e-02 9.3397e-01 8.3285e-02 9.8989e-01 8.0967e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 208: 1.0250e+02 -4.0999e+00 -2.2759e+00 -4.0330e+00 -1.0001e+00 -9.6916e-02 5.9586e-03 2.3690e-05 5.3811e-02 2.9674e-02 1.9979e-01 8.1206e-02 9.3593e-01 8.4094e-02 9.8891e-01 8.1107e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 209: 1.0250e+02 -4.0998e+00 -2.2836e+00 -4.0344e+00 -1.0016e+00 -8.9119e-02 5.6137e-03 2.3512e-05 5.4159e-02 2.9780e-02 1.9778e-01 8.2635e-02 9.4080e-01 8.3757e-02 9.9062e-01 8.0979e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 210: 1.0251e+02 -4.0998e+00 -2.2898e+00 -4.0334e+00 -1.0017e+00 -8.3861e-02 5.2428e-03 2.3117e-05 5.4271e-02 2.9112e-02 1.9539e-01 8.3602e-02 9.4410e-01 8.4262e-02 9.8944e-01 8.1260e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 211: 1.0251e+02 -4.0998e+00 -2.2968e+00 -4.0329e+00 -9.9953e-01 -8.2036e-02 4.9312e-03 2.2863e-05 5.5392e-02 2.8432e-02 1.9466e-01 8.3724e-02 9.5395e-01 8.4317e-02 9.9876e-01 8.1402e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 212: 1.0251e+02 -4.0997e+00 -2.2982e+00 -4.0327e+00 -1.0018e+00 -8.2942e-02 4.6622e-03 2.3364e-05 5.5864e-02 2.7552e-02 1.9313e-01 8.3815e-02 9.5374e-01 8.4223e-02 1.0049e+00 8.1479e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 213: 1.0251e+02 -4.0995e+00 -2.2996e+00 -4.0322e+00 -1.0027e+00 -8.4931e-02 4.4988e-03 2.4085e-05 5.6000e-02 2.6729e-02 1.9184e-01 8.3522e-02 9.5091e-01 8.4321e-02 1.0026e+00 8.1310e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 214: 1.0251e+02 -4.0994e+00 -2.2997e+00 -4.0326e+00 -1.0033e+00 -8.7810e-02 4.3582e-03 2.5253e-05 5.6470e-02 2.6179e-02 1.9110e-01 8.5338e-02 9.5311e-01 8.4118e-02 1.0062e+00 8.1320e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 215: 1.0251e+02 -4.0993e+00 -2.3013e+00 -4.0331e+00 -1.0042e+00 -8.5053e-02 4.3765e-03 2.6370e-05 5.6978e-02 2.5984e-02 1.8960e-01 8.6633e-02 9.5505e-01 8.3787e-02 1.0092e+00 8.1298e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 216: 1.0251e+02 -4.0993e+00 -2.3032e+00 -4.0320e+00 -1.0033e+00 -8.5521e-02 4.4127e-03 2.7607e-05 5.7092e-02 2.5514e-02 1.8916e-01 8.8986e-02 9.5571e-01 8.3655e-02 1.0106e+00 8.1177e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 217: 1.0251e+02 -4.0993e+00 -2.3050e+00 -4.0309e+00 -1.0039e+00 -8.5267e-02 4.4663e-03 2.8101e-05 5.7536e-02 2.5186e-02 1.8803e-01 9.0776e-02 9.5624e-01 8.3792e-02 1.0100e+00 8.1214e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 218: 1.0251e+02 -4.0993e+00 -2.3068e+00 -4.0309e+00 -1.0052e+00 -8.3353e-02 4.4833e-03 2.7541e-05 5.7391e-02 2.4589e-02 1.8691e-01 9.4302e-02 9.5168e-01 8.4114e-02 1.0124e+00 8.1211e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 219: 1.0251e+02 -4.0993e+00 -2.3077e+00 -4.0316e+00 -1.0049e+00 -8.0885e-02 4.4529e-03 2.6825e-05 5.7273e-02 2.3909e-02 1.8700e-01 9.6040e-02 9.4675e-01 8.4115e-02 1.0115e+00 8.1075e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 220: 1.0251e+02 -4.0993e+00 -2.3095e+00 -4.0327e+00 -1.0051e+00 -7.6386e-02 4.5217e-03 2.6724e-05 5.7342e-02 2.3648e-02 1.8752e-01 9.7466e-02 9.4316e-01 8.4134e-02 1.0099e+00 8.1206e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 221: 1.0251e+02 -4.0993e+00 -2.3120e+00 -4.0339e+00 -1.0050e+00 -7.3314e-02 4.5361e-03 2.6133e-05 5.7387e-02 2.3612e-02 1.8744e-01 9.9108e-02 9.4164e-01 8.4073e-02 1.0096e+00 8.1143e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 222: 1.0251e+02 -4.0993e+00 -2.3136e+00 -4.0355e+00 -1.0049e+00 -6.8041e-02 4.5806e-03 2.5728e-05 5.7827e-02 2.3466e-02 1.8681e-01 9.9150e-02 9.4237e-01 8.3991e-02 1.0116e+00 8.1192e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 223: 1.0251e+02 -4.0993e+00 -2.3144e+00 -4.0364e+00 -1.0047e+00 -6.6770e-02 4.5349e-03 2.5412e-05 5.8823e-02 2.3232e-02 1.8728e-01 9.9882e-02 9.4051e-01 8.3808e-02 1.0097e+00 8.1028e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 224: 1.0251e+02 -4.0992e+00 -2.3155e+00 -4.0373e+00 -1.0040e+00 -6.4487e-02 4.4985e-03 2.5094e-05 6.0294e-02 2.3022e-02 1.8652e-01 1.0114e-01 9.3800e-01 8.3696e-02 1.0099e+00 8.0990e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 225: 1.0251e+02 -4.0992e+00 -2.3167e+00 -4.0384e+00 -1.0041e+00 -6.2966e-02 4.4783e-03 2.4741e-05 6.0569e-02 2.2900e-02 1.8622e-01 1.0072e-01 9.3574e-01 8.3833e-02 1.0075e+00 8.0893e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 226: 1.0251e+02 -4.0993e+00 -2.3173e+00 -4.0395e+00 -1.0036e+00 -6.0541e-02 4.4466e-03 2.4601e-05 6.0661e-02 2.2897e-02 1.8544e-01 1.0160e-01 9.3842e-01 8.3565e-02 1.0064e+00 8.1006e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 227: 1.0251e+02 -4.0993e+00 -2.3183e+00 -4.0403e+00 -1.0028e+00 -5.9061e-02 4.4290e-03 2.4610e-05 6.1093e-02 2.2836e-02 1.8582e-01 1.0184e-01 9.3983e-01 8.3421e-02 1.0066e+00 8.1225e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 228: 1.0251e+02 -4.0993e+00 -2.3190e+00 -4.0405e+00 -1.0027e+00 -5.8994e-02 4.4377e-03 2.4228e-05 6.0957e-02 2.2540e-02 1.8424e-01 1.0104e-01 9.4056e-01 8.3559e-02 1.0085e+00 8.1266e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 229: 1.0251e+02 -4.0993e+00 -2.3206e+00 -4.0398e+00 -1.0026e+00 -5.9258e-02 4.5021e-03 2.3801e-05 6.0331e-02 2.2380e-02 1.8409e-01 9.9681e-02 9.4320e-01 8.3678e-02 1.0111e+00 8.1236e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 230: 1.0251e+02 -4.0994e+00 -2.3217e+00 -4.0401e+00 -1.0028e+00 -5.7766e-02 4.5320e-03 2.3519e-05 5.9913e-02 2.2317e-02 1.8484e-01 9.9325e-02 9.4418e-01 8.3884e-02 1.0144e+00 8.1294e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 231: 1.0251e+02 -4.0994e+00 -2.3223e+00 -4.0400e+00 -1.0036e+00 -5.7213e-02 4.6519e-03 2.3658e-05 5.9386e-02 2.2185e-02 1.8526e-01 9.8374e-02 9.4356e-01 8.4167e-02 1.0171e+00 8.1315e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 232: 1.0251e+02 -4.0994e+00 -2.3231e+00 -4.0400e+00 -1.0045e+00 -5.5248e-02 4.7067e-03 2.3117e-05 5.9583e-02 2.2248e-02 1.8574e-01 9.7396e-02 9.4340e-01 8.4212e-02 1.0179e+00 8.1401e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 233: 1.0251e+02 -4.0994e+00 -2.3237e+00 -4.0401e+00 -1.0046e+00 -5.4085e-02 4.7534e-03 2.2858e-05 5.8985e-02 2.2248e-02 1.8649e-01 9.7364e-02 9.4271e-01 8.4248e-02 1.0189e+00 8.1456e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 234: 1.0251e+02 -4.0995e+00 -2.3238e+00 -4.0400e+00 -1.0042e+00 -5.2957e-02 4.8433e-03 2.2715e-05 5.8868e-02 2.2174e-02 1.8630e-01 9.7975e-02 9.4382e-01 8.4160e-02 1.0210e+00 8.1665e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 235: 1.0251e+02 -4.0995e+00 -2.3248e+00 -4.0396e+00 -1.0044e+00 -5.3132e-02 4.8769e-03 2.2540e-05 5.9052e-02 2.2120e-02 1.8627e-01 9.8772e-02 9.4330e-01 8.4170e-02 1.0196e+00 8.1627e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 236: 1.0251e+02 -4.0995e+00 -2.3244e+00 -4.0392e+00 -1.0052e+00 -5.3786e-02 4.8860e-03 2.2664e-05 5.8981e-02 2.2095e-02 1.8771e-01 9.8852e-02 9.4172e-01 8.4214e-02 1.0191e+00 8.1698e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 237: 1.0251e+02 -4.0996e+00 -2.3231e+00 -4.0386e+00 -1.0056e+00 -5.5158e-02 4.8731e-03 2.2576e-05 5.8788e-02 2.2037e-02 1.8860e-01 9.9599e-02 9.4242e-01 8.4097e-02 1.0198e+00 8.1684e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 238: 1.0251e+02 -4.0996e+00 -2.3222e+00 -4.0384e+00 -1.0054e+00 -5.6412e-02 4.8673e-03 2.2575e-05 5.8733e-02 2.1962e-02 1.8874e-01 9.9196e-02 9.4097e-01 8.4103e-02 1.0208e+00 8.1649e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 239: 1.0251e+02 -4.0996e+00 -2.3212e+00 -4.0382e+00 -1.0068e+00 -5.7131e-02 4.8223e-03 2.2398e-05 5.8674e-02 2.1817e-02 1.8926e-01 9.9323e-02 9.4261e-01 8.4059e-02 1.0229e+00 8.1670e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 240: 1.0251e+02 -4.0996e+00 -2.3216e+00 -4.0376e+00 -1.0073e+00 -5.6962e-02 4.7984e-03 2.2260e-05 5.8558e-02 2.1632e-02 1.8892e-01 9.9232e-02 9.4434e-01 8.4130e-02 1.0237e+00 8.1679e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 241: 1.0251e+02 -4.0996e+00 -2.3216e+00 -4.0371e+00 -1.0078e+00 -5.6984e-02 4.7767e-03 2.2074e-05 5.9552e-02 2.1436e-02 1.8860e-01 9.9285e-02 9.4491e-01 8.4026e-02 1.0247e+00 8.1680e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 242: 1.0251e+02 -4.0996e+00 -2.3222e+00 -4.0372e+00 -1.0079e+00 -5.6422e-02 4.7880e-03 2.2014e-05 6.0033e-02 2.1277e-02 1.8860e-01 9.8674e-02 9.4359e-01 8.3991e-02 1.0255e+00 8.1634e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 243: 1.0251e+02 -4.0995e+00 -2.3227e+00 -4.0376e+00 -1.0079e+00 -5.4330e-02 4.7944e-03 2.1687e-05 6.0189e-02 2.1088e-02 1.8830e-01 9.7952e-02 9.4207e-01 8.4036e-02 1.0257e+00 8.1666e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 244: 1.0251e+02 -4.0995e+00 -2.3237e+00 -4.0385e+00 -1.0076e+00 -5.2834e-02 4.7916e-03 2.1467e-05 6.0432e-02 2.1062e-02 1.8810e-01 9.7065e-02 9.4039e-01 8.4075e-02 1.0248e+00 8.1599e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 245: 1.0251e+02 -4.0995e+00 -2.3249e+00 -4.0390e+00 -1.0073e+00 -5.0542e-02 4.7926e-03 2.1549e-05 6.1095e-02 2.0981e-02 1.8814e-01 9.6715e-02 9.3900e-01 8.4049e-02 1.0226e+00 8.1505e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 246: 1.0251e+02 -4.0995e+00 -2.3261e+00 -4.0398e+00 -1.0066e+00 -4.7686e-02 4.8114e-03 2.1557e-05 6.1692e-02 2.0969e-02 1.8783e-01 9.6477e-02 9.3880e-01 8.4024e-02 1.0211e+00 8.1456e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 247: 1.0251e+02 -4.0996e+00 -2.3270e+00 -4.0406e+00 -1.0063e+00 -4.5794e-02 4.7864e-03 2.1709e-05 6.1819e-02 2.0928e-02 1.8765e-01 9.5549e-02 9.3939e-01 8.4076e-02 1.0201e+00 8.1427e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 248: 1.0251e+02 -4.0995e+00 -2.3282e+00 -4.0412e+00 -1.0064e+00 -4.3009e-02 4.7307e-03 2.1707e-05 6.2309e-02 2.0970e-02 1.8795e-01 9.5221e-02 9.3898e-01 8.4080e-02 1.0197e+00 8.1501e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 249: 1.0251e+02 -4.0996e+00 -2.3298e+00 -4.0417e+00 -1.0070e+00 -4.1062e-02 4.7070e-03 2.1737e-05 6.2607e-02 2.1094e-02 1.8796e-01 9.5103e-02 9.3917e-01 8.4069e-02 1.0194e+00 8.1525e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 250: 1.0251e+02 -4.0996e+00 -2.3313e+00 -4.0420e+00 -1.0073e+00 -3.9250e-02 4.7191e-03 2.1947e-05 6.2963e-02 2.1053e-02 1.8834e-01 9.4954e-02 9.3851e-01 8.4115e-02 1.0190e+00 8.1496e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 251: 1.0251e+02 -4.0997e+00 -2.3317e+00 -4.0424e+00 -1.0078e+00 -3.7549e-02 4.7501e-03 2.2063e-05 6.3160e-02 2.0958e-02 1.8840e-01 9.4783e-02 9.3749e-01 8.4137e-02 1.0185e+00 8.1476e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 252: 1.0251e+02 -4.0997e+00 -2.3319e+00 -4.0424e+00 -1.0083e+00 -3.6657e-02 4.7441e-03 2.2081e-05 6.3250e-02 2.0891e-02 1.8911e-01 9.4954e-02 9.3708e-01 8.4108e-02 1.0180e+00 8.1479e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 253: 1.0251e+02 -4.0997e+00 -2.3323e+00 -4.0425e+00 -1.0085e+00 -3.5826e-02 4.7409e-03 2.2021e-05 6.3513e-02 2.0810e-02 1.8920e-01 9.5196e-02 9.3509e-01 8.4179e-02 1.0184e+00 8.1440e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 254: 1.0251e+02 -4.0997e+00 -2.3324e+00 -4.0426e+00 -1.0086e+00 -3.6456e-02 4.7046e-03 2.1929e-05 6.3535e-02 2.0859e-02 1.9010e-01 9.5077e-02 9.3362e-01 8.4279e-02 1.0185e+00 8.1371e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 255: 1.0251e+02 -4.0997e+00 -2.3313e+00 -4.0424e+00 -1.0088e+00 -3.7358e-02 4.6636e-03 2.1827e-05 6.3864e-02 2.0820e-02 1.9126e-01 9.4979e-02 9.3183e-01 8.4380e-02 1.0185e+00 8.1434e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 256: 1.0251e+02 -4.0997e+00 -2.3306e+00 -4.0423e+00 -1.0086e+00 -3.8558e-02 4.6418e-03 2.1776e-05 6.4176e-02 2.0845e-02 1.9175e-01 9.4890e-02 9.3144e-01 8.4436e-02 1.0188e+00 8.1420e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 257: 1.0251e+02 -4.0997e+00 -2.3297e+00 -4.0419e+00 -1.0092e+00 -3.9580e-02 4.6134e-03 2.1742e-05 6.4408e-02 2.0751e-02 1.9188e-01 9.4692e-02 9.3113e-01 8.4507e-02 1.0187e+00 8.1412e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 258: 1.0251e+02 -4.0997e+00 -2.3287e+00 -4.0415e+00 -1.0090e+00 -4.0619e-02 4.5918e-03 2.1710e-05 6.4634e-02 2.0663e-02 1.9172e-01 9.4422e-02 9.3104e-01 8.4479e-02 1.0189e+00 8.1395e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 259: 1.0251e+02 -4.0997e+00 -2.3284e+00 -4.0412e+00 -1.0086e+00 -4.1245e-02 4.5889e-03 2.1741e-05 6.5035e-02 2.0678e-02 1.9132e-01 9.3998e-02 9.2986e-01 8.4448e-02 1.0177e+00 8.1368e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 260: 1.0251e+02 -4.0997e+00 -2.3283e+00 -4.0410e+00 -1.0084e+00 -4.1907e-02 4.5818e-03 2.1877e-05 6.5755e-02 2.0691e-02 1.9113e-01 9.3631e-02 9.2955e-01 8.4378e-02 1.0172e+00 8.1346e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 261: 1.0251e+02 -4.0998e+00 -2.3282e+00 -4.0409e+00 -1.0087e+00 -4.2022e-02 4.5724e-03 2.1946e-05 6.6396e-02 2.0714e-02 1.9084e-01 9.3140e-02 9.2882e-01 8.4426e-02 1.0166e+00 8.1329e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 262: 1.0251e+02 -4.0997e+00 -2.3275e+00 -4.0408e+00 -1.0092e+00 -4.2439e-02 4.5357e-03 2.1842e-05 6.6895e-02 2.0692e-02 1.9082e-01 9.2527e-02 9.2811e-01 8.4447e-02 1.0168e+00 8.1339e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 263: 1.0251e+02 -4.0998e+00 -2.3269e+00 -4.0407e+00 -1.0097e+00 -4.2867e-02 4.5244e-03 2.1830e-05 6.7068e-02 2.0721e-02 1.9077e-01 9.2003e-02 9.2800e-01 8.4366e-02 1.0171e+00 8.1343e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 264: 1.0251e+02 -4.0998e+00 -2.3262e+00 -4.0403e+00 -1.0102e+00 -4.3066e-02 4.4987e-03 2.1812e-05 6.7458e-02 2.0718e-02 1.9065e-01 9.1528e-02 9.2710e-01 8.4389e-02 1.0163e+00 8.1355e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 265: 1.0251e+02 -4.0998e+00 -2.3264e+00 -4.0401e+00 -1.0105e+00 -4.3042e-02 4.4865e-03 2.1721e-05 6.7680e-02 2.0722e-02 1.9057e-01 9.1243e-02 9.2631e-01 8.4430e-02 1.0154e+00 8.1321e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 266: 1.0251e+02 -4.0998e+00 -2.3264e+00 -4.0397e+00 -1.0107e+00 -4.3247e-02 4.4552e-03 2.1609e-05 6.8246e-02 2.0757e-02 1.9054e-01 9.1222e-02 9.2659e-01 8.4381e-02 1.0154e+00 8.1290e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 267: 1.0251e+02 -4.0999e+00 -2.3261e+00 -4.0396e+00 -1.0107e+00 -4.4145e-02 4.4367e-03 2.1505e-05 6.8834e-02 2.0735e-02 1.9038e-01 9.1594e-02 9.2661e-01 8.4338e-02 1.0153e+00 8.1308e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 268: 1.0251e+02 -4.0999e+00 -2.3249e+00 -4.0395e+00 -1.0112e+00 -4.5394e-02 4.4239e-03 2.1411e-05 6.9776e-02 2.0749e-02 1.9017e-01 9.1916e-02 9.2711e-01 8.4286e-02 1.0158e+00 8.1400e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 269: 1.0251e+02 -4.0999e+00 -2.3236e+00 -4.0391e+00 -1.0112e+00 -4.6744e-02 4.4119e-03 2.1310e-05 7.0528e-02 2.0709e-02 1.9026e-01 9.2008e-02 9.2638e-01 8.4248e-02 1.0160e+00 8.1389e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 270: 1.0251e+02 -4.0999e+00 -2.3231e+00 -4.0388e+00 -1.0116e+00 -4.7514e-02 4.3782e-03 2.1160e-05 7.1513e-02 2.0724e-02 1.9006e-01 9.1551e-02 9.2668e-01 8.4246e-02 1.0149e+00 8.1419e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 271: 1.0251e+02 -4.0999e+00 -2.3228e+00 -4.0387e+00 -1.0117e+00 -4.7755e-02 4.3389e-03 2.1121e-05 7.1868e-02 2.0670e-02 1.8969e-01 9.1369e-02 9.2678e-01 8.4228e-02 1.0145e+00 8.1437e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 272: 1.0251e+02 -4.0999e+00 -2.3222e+00 -4.0387e+00 -1.0121e+00 -4.8163e-02 4.3080e-03 2.1146e-05 7.2226e-02 2.0710e-02 1.8983e-01 9.0962e-02 9.2639e-01 8.4261e-02 1.0132e+00 8.1523e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 273: 1.0251e+02 -4.0999e+00 -2.3216e+00 -4.0389e+00 -1.0122e+00 -4.8336e-02 4.2916e-03 2.1202e-05 7.2734e-02 2.0689e-02 1.8982e-01 9.0422e-02 9.2618e-01 8.4177e-02 1.0134e+00 8.1561e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 274: 1.0251e+02 -4.0999e+00 -2.3211e+00 -4.0388e+00 -1.0124e+00 -4.8286e-02 4.2592e-03 2.1201e-05 7.3324e-02 2.0658e-02 1.9015e-01 8.9938e-02 9.2530e-01 8.4133e-02 1.0133e+00 8.1562e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 275: 1.0251e+02 -4.0999e+00 -2.3211e+00 -4.0387e+00 -1.0128e+00 -4.8312e-02 4.2368e-03 2.1092e-05 7.3673e-02 2.0639e-02 1.9018e-01 8.9708e-02 9.2404e-01 8.4155e-02 1.0130e+00 8.1535e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 276: 1.0251e+02 -4.0999e+00 -2.3212e+00 -4.0386e+00 -1.0126e+00 -4.8249e-02 4.2070e-03 2.0985e-05 7.4089e-02 2.0674e-02 1.8992e-01 8.9341e-02 9.2339e-01 8.4163e-02 1.0121e+00 8.1515e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 277: 1.0251e+02 -4.0999e+00 -2.3212e+00 -4.0387e+00 -1.0123e+00 -4.8743e-02 4.1781e-03 2.0914e-05 7.4488e-02 2.0779e-02 1.8959e-01 8.9106e-02 9.2352e-01 8.4100e-02 1.0112e+00 8.1477e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 278: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0385e+00 -1.0118e+00 -4.9468e-02 4.1782e-03 2.0802e-05 7.4843e-02 2.0859e-02 1.8970e-01 8.8995e-02 9.2374e-01 8.4037e-02 1.0103e+00 8.1458e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 279: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0384e+00 -1.0115e+00 -4.9612e-02 4.1736e-03 2.0737e-05 7.5385e-02 2.0899e-02 1.8969e-01 8.8806e-02 9.2347e-01 8.3989e-02 1.0095e+00 8.1440e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 280: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0382e+00 -1.0114e+00 -5.0460e-02 4.1900e-03 2.0708e-05 7.6051e-02 2.0933e-02 1.8968e-01 8.9243e-02 9.2293e-01 8.3972e-02 1.0085e+00 8.1467e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 281: 1.0251e+02 -4.0999e+00 -2.3215e+00 -4.0378e+00 -1.0113e+00 -5.0583e-02 4.2096e-03 2.0638e-05 7.6759e-02 2.1003e-02 1.8941e-01 8.9450e-02 9.2294e-01 8.4027e-02 1.0080e+00 8.1467e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 282: 1.0251e+02 -4.0999e+00 -2.3218e+00 -4.0380e+00 -1.0114e+00 -5.0276e-02 4.2061e-03 2.0669e-05 7.7323e-02 2.1016e-02 1.8946e-01 8.9456e-02 9.2386e-01 8.3996e-02 1.0095e+00 8.1446e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 283: 1.0251e+02 -4.0999e+00 -2.3224e+00 -4.0383e+00 -1.0115e+00 -4.9357e-02 4.2005e-03 2.0601e-05 7.7856e-02 2.1072e-02 1.8968e-01 8.9327e-02 9.2480e-01 8.3964e-02 1.0101e+00 8.1418e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 284: 1.0251e+02 -4.0999e+00 -2.3226e+00 -4.0386e+00 -1.0110e+00 -4.8703e-02 4.1977e-03 2.0549e-05 7.8183e-02 2.1122e-02 1.8956e-01 8.9430e-02 9.2470e-01 8.3898e-02 1.0098e+00 8.1428e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 285: 1.0251e+02 -4.0999e+00 -2.3232e+00 -4.0389e+00 -1.0110e+00 -4.7526e-02 4.2063e-03 2.0546e-05 7.8449e-02 2.1151e-02 1.8967e-01 8.9133e-02 9.2438e-01 8.3889e-02 1.0089e+00 8.1428e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 286: 1.0251e+02 -4.0999e+00 -2.3242e+00 -4.0389e+00 -1.0103e+00 -4.6191e-02 4.2076e-03 2.0486e-05 7.8629e-02 2.1133e-02 1.8970e-01 8.8773e-02 9.2471e-01 8.3861e-02 1.0087e+00 8.1427e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 287: 1.0251e+02 -4.0999e+00 -2.3243e+00 -4.0391e+00 -1.0105e+00 -4.5159e-02 4.1980e-03 2.0488e-05 7.8916e-02 2.1071e-02 1.8955e-01 8.8297e-02 9.2415e-01 8.3957e-02 1.0084e+00 8.1464e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 288: 1.0251e+02 -4.0999e+00 -2.3237e+00 -4.0392e+00 -1.0109e+00 -4.4970e-02 4.1921e-03 2.0495e-05 7.8764e-02 2.0953e-02 1.8988e-01 8.8160e-02 9.2539e-01 8.3963e-02 1.0103e+00 8.1466e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 289: 1.0251e+02 -4.0999e+00 -2.3232e+00 -4.0392e+00 -1.0114e+00 -4.4592e-02 4.1763e-03 2.0584e-05 7.8632e-02 2.0841e-02 1.8982e-01 8.8037e-02 9.2559e-01 8.4031e-02 1.0111e+00 8.1469e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 290: 1.0251e+02 -4.0999e+00 -2.3228e+00 -4.0393e+00 -1.0118e+00 -4.4506e-02 4.1574e-03 2.0479e-05 7.8482e-02 2.0726e-02 1.8968e-01 8.7644e-02 9.2519e-01 8.4079e-02 1.0117e+00 8.1474e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 291: 1.0251e+02 -4.0999e+00 -2.3223e+00 -4.0392e+00 -1.0120e+00 -4.4578e-02 4.1365e-03 2.0488e-05 7.8220e-02 2.0662e-02 1.8952e-01 8.7558e-02 9.2534e-01 8.4128e-02 1.0119e+00 8.1459e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 292: 1.0251e+02 -4.0999e+00 -2.3219e+00 -4.0392e+00 -1.0120e+00 -4.4486e-02 4.1205e-03 2.0514e-05 7.8288e-02 2.0601e-02 1.8947e-01 8.7669e-02 9.2591e-01 8.4106e-02 1.0124e+00 8.1443e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 293: 1.0251e+02 -4.0999e+00 -2.3217e+00 -4.0395e+00 -1.0120e+00 -4.3914e-02 4.1076e-03 2.0606e-05 7.8474e-02 2.0557e-02 1.8960e-01 8.7970e-02 9.2580e-01 8.4052e-02 1.0124e+00 8.1443e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 294: 1.0251e+02 -4.0998e+00 -2.3218e+00 -4.0399e+00 -1.0123e+00 -4.3173e-02 4.1124e-03 2.0598e-05 7.8561e-02 2.0485e-02 1.8979e-01 8.7954e-02 9.2624e-01 8.4027e-02 1.0132e+00 8.1419e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 295: 1.0251e+02 -4.0998e+00 -2.3220e+00 -4.0399e+00 -1.0123e+00 -4.2805e-02 4.1150e-03 2.0599e-05 7.8804e-02 2.0397e-02 1.8985e-01 8.8079e-02 9.2637e-01 8.3980e-02 1.0139e+00 8.1382e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 296: 1.0251e+02 -4.0998e+00 -2.3224e+00 -4.0401e+00 -1.0121e+00 -4.2813e-02 4.1342e-03 2.0618e-05 7.9093e-02 2.0359e-02 1.8980e-01 8.8328e-02 9.2555e-01 8.3955e-02 1.0137e+00 8.1344e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 297: 1.0251e+02 -4.0998e+00 -2.3225e+00 -4.0403e+00 -1.0118e+00 -4.2861e-02 4.1653e-03 2.0599e-05 7.9236e-02 2.0318e-02 1.8969e-01 8.8659e-02 9.2477e-01 8.3916e-02 1.0135e+00 8.1323e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 298: 1.0251e+02 -4.0997e+00 -2.3228e+00 -4.0404e+00 -1.0116e+00 -4.2874e-02 4.2066e-03 2.0567e-05 7.9391e-02 2.0249e-02 1.8973e-01 8.8706e-02 9.2359e-01 8.3939e-02 1.0134e+00 8.1277e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 299: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0404e+00 -1.0113e+00 -4.3190e-02 4.2168e-03 2.0532e-05 7.9379e-02 2.0187e-02 1.8973e-01 8.8757e-02 9.2294e-01 8.3916e-02 1.0137e+00 8.1243e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 300: 1.0251e+02 -4.0997e+00 -2.3221e+00 -4.0405e+00 -1.0111e+00 -4.3480e-02 4.2289e-03 2.0490e-05 7.9314e-02 2.0140e-02 1.8983e-01 8.8620e-02 9.2242e-01 8.3900e-02 1.0137e+00 8.1210e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 301: 1.0251e+02 -4.0997e+00 -2.3213e+00 -4.0404e+00 -1.0109e+00 -4.4169e-02 4.2524e-03 2.0546e-05 7.9499e-02 2.0117e-02 1.8991e-01 8.8503e-02 9.2226e-01 8.3843e-02 1.0136e+00 8.1235e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 302: 1.0251e+02 -4.0997e+00 -2.3205e+00 -4.0403e+00 -1.0108e+00 -4.5199e-02 4.2709e-03 2.0511e-05 7.9674e-02 2.0085e-02 1.8969e-01 8.8687e-02 9.2207e-01 8.3852e-02 1.0134e+00 8.1262e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 303: 1.0251e+02 -4.0997e+00 -2.3199e+00 -4.0401e+00 -1.0106e+00 -4.6193e-02 4.2807e-03 2.0440e-05 7.9845e-02 2.0104e-02 1.8985e-01 8.8661e-02 9.2135e-01 8.3843e-02 1.0128e+00 8.1274e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 304: 1.0251e+02 -4.0997e+00 -2.3189e+00 -4.0398e+00 -1.0105e+00 -4.7180e-02 4.3058e-03 2.0450e-05 7.9808e-02 2.0159e-02 1.8987e-01 8.8660e-02 9.2076e-01 8.3856e-02 1.0120e+00 8.1277e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 305: 1.0251e+02 -4.0997e+00 -2.3180e+00 -4.0396e+00 -1.0102e+00 -4.8474e-02 4.3050e-03 2.0527e-05 7.9932e-02 2.0184e-02 1.8970e-01 8.8567e-02 9.1986e-01 8.3867e-02 1.0111e+00 8.1290e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 306: 1.0251e+02 -4.0997e+00 -2.3175e+00 -4.0393e+00 -1.0101e+00 -4.9308e-02 4.3055e-03 2.0586e-05 8.0113e-02 2.0178e-02 1.8971e-01 8.8307e-02 9.1930e-01 8.3865e-02 1.0112e+00 8.1290e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 307: 1.0251e+02 -4.0997e+00 -2.3175e+00 -4.0393e+00 -1.0103e+00 -4.9278e-02 4.3027e-03 2.0441e-05 8.0168e-02 2.0211e-02 1.8973e-01 8.7993e-02 9.1919e-01 8.3837e-02 1.0109e+00 8.1287e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 308: 1.0251e+02 -4.0998e+00 -2.3175e+00 -4.0394e+00 -1.0103e+00 -4.9430e-02 4.2899e-03 2.0384e-05 8.0417e-02 2.0187e-02 1.8983e-01 8.7757e-02 9.1937e-01 8.3778e-02 1.0106e+00 8.1289e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 309: 1.0251e+02 -4.0998e+00 -2.3175e+00 -4.0393e+00 -1.0103e+00 -4.9319e-02 4.2773e-03 2.0349e-05 8.0807e-02 2.0161e-02 1.8959e-01 8.7493e-02 9.1950e-01 8.3734e-02 1.0108e+00 8.1279e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 310: 1.0251e+02 -4.0998e+00 -2.3174e+00 -4.0393e+00 -1.0101e+00 -4.8880e-02 4.2710e-03 2.0327e-05 8.1202e-02 2.0116e-02 1.8983e-01 8.7251e-02 9.1864e-01 8.3730e-02 1.0108e+00 8.1294e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 311: 1.0251e+02 -4.0998e+00 -2.3174e+00 -4.0394e+00 -1.0100e+00 -4.8080e-02 4.2611e-03 2.0272e-05 8.1332e-02 2.0078e-02 1.9003e-01 8.6995e-02 9.1844e-01 8.3699e-02 1.0105e+00 8.1319e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 312: 1.0251e+02 -4.0998e+00 -2.3173e+00 -4.0394e+00 -1.0100e+00 -4.7724e-02 4.2663e-03 2.0239e-05 8.1553e-02 2.0021e-02 1.8982e-01 8.6721e-02 9.1838e-01 8.3721e-02 1.0100e+00 8.1312e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 313: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0395e+00 -1.0100e+00 -4.7216e-02 4.2775e-03 2.0213e-05 8.2001e-02 1.9971e-02 1.8980e-01 8.6651e-02 9.1837e-01 8.3697e-02 1.0100e+00 8.1318e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 314: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0398e+00 -1.0100e+00 -4.6902e-02 4.2949e-03 2.0265e-05 8.2392e-02 1.9922e-02 1.8988e-01 8.6426e-02 9.1845e-01 8.3722e-02 1.0103e+00 8.1309e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 315: 1.0251e+02 -4.0998e+00 -2.3168e+00 -4.0399e+00 -1.0102e+00 -4.6480e-02 4.3206e-03 2.0314e-05 8.2534e-02 1.9912e-02 1.8972e-01 8.6211e-02 9.1792e-01 8.3758e-02 1.0103e+00 8.1337e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 316: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0400e+00 -1.0100e+00 -4.6238e-02 4.3456e-03 2.0323e-05 8.2729e-02 1.9936e-02 1.8975e-01 8.5856e-02 9.1759e-01 8.3814e-02 1.0095e+00 8.1353e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 317: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0402e+00 -1.0103e+00 -4.5470e-02 4.3521e-03 2.0275e-05 8.2864e-02 1.9965e-02 1.8980e-01 8.5438e-02 9.1755e-01 8.3894e-02 1.0088e+00 8.1373e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 318: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0402e+00 -1.0106e+00 -4.5001e-02 4.3661e-03 2.0191e-05 8.2949e-02 1.9983e-02 1.9001e-01 8.5203e-02 9.1746e-01 8.3944e-02 1.0078e+00 8.1401e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 319: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0403e+00 -1.0108e+00 -4.4545e-02 4.3665e-03 2.0114e-05 8.2694e-02 2.0003e-02 1.9041e-01 8.4997e-02 9.1774e-01 8.3940e-02 1.0073e+00 8.1417e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 320: 1.0251e+02 -4.0998e+00 -2.3171e+00 -4.0402e+00 -1.0109e+00 -4.4419e-02 4.3600e-03 2.0043e-05 8.2516e-02 1.9999e-02 1.9044e-01 8.4873e-02 9.1798e-01 8.3932e-02 1.0070e+00 8.1420e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 321: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0401e+00 -1.0107e+00 -4.4267e-02 4.3539e-03 1.9995e-05 8.2307e-02 1.9967e-02 1.9050e-01 8.4982e-02 9.1814e-01 8.3919e-02 1.0067e+00 8.1429e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 322: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0400e+00 -1.0106e+00 -4.4240e-02 4.3331e-03 1.9984e-05 8.2305e-02 1.9961e-02 1.9054e-01 8.5443e-02 9.1821e-01 8.3910e-02 1.0065e+00 8.1424e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 323: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0397e+00 -1.0105e+00 -4.4793e-02 4.3199e-03 1.9921e-05 8.2300e-02 1.9935e-02 1.9078e-01 8.6081e-02 9.1836e-01 8.3854e-02 1.0062e+00 8.1448e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 324: 1.0251e+02 -4.0998e+00 -2.3167e+00 -4.0395e+00 -1.0104e+00 -4.4862e-02 4.3167e-03 1.9926e-05 8.2063e-02 1.9919e-02 1.9086e-01 8.6736e-02 9.1865e-01 8.3834e-02 1.0060e+00 8.1439e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 325: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0394e+00 -1.0103e+00 -4.5123e-02 4.3012e-03 1.9902e-05 8.1871e-02 1.9888e-02 1.9103e-01 8.7030e-02 9.1829e-01 8.3865e-02 1.0059e+00 8.1436e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 326: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0393e+00 -1.0100e+00 -4.5111e-02 4.2839e-03 1.9869e-05 8.2016e-02 1.9843e-02 1.9083e-01 8.7106e-02 9.1802e-01 8.3847e-02 1.0058e+00 8.1427e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 327: 1.0251e+02 -4.0998e+00 -2.3165e+00 -4.0393e+00 -1.0101e+00 -4.5297e-02 4.2847e-03 1.9858e-05 8.2297e-02 1.9823e-02 1.9075e-01 8.7398e-02 9.1826e-01 8.3771e-02 1.0054e+00 8.1451e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 328: 1.0251e+02 -4.0998e+00 -2.3162e+00 -4.0393e+00 -1.0100e+00 -4.5633e-02 4.2864e-03 1.9877e-05 8.2486e-02 1.9809e-02 1.9060e-01 8.7863e-02 9.1822e-01 8.3706e-02 1.0049e+00 8.1482e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 329: 1.0251e+02 -4.0998e+00 -2.3163e+00 -4.0392e+00 -1.0098e+00 -4.5698e-02 4.3097e-03 1.9869e-05 8.2469e-02 1.9795e-02 1.9047e-01 8.8220e-02 9.1805e-01 8.3704e-02 1.0045e+00 8.1502e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 330: 1.0251e+02 -4.0998e+00 -2.3168e+00 -4.0390e+00 -1.0099e+00 -4.5752e-02 4.3120e-03 1.9810e-05 8.2684e-02 1.9770e-02 1.9049e-01 8.8495e-02 9.1779e-01 8.3731e-02 1.0046e+00 8.1500e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 331: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0390e+00 -1.0099e+00 -4.5957e-02 4.3052e-03 1.9736e-05 8.2748e-02 1.9734e-02 1.9034e-01 8.8651e-02 9.1818e-01 8.3707e-02 1.0050e+00 8.1489e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 332: 1.0251e+02 -4.0998e+00 -2.3171e+00 -4.0391e+00 -1.0098e+00 -4.5788e-02 4.2994e-03 1.9733e-05 8.2906e-02 1.9711e-02 1.9035e-01 8.8647e-02 9.1835e-01 8.3660e-02 1.0052e+00 8.1490e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 333: 1.0251e+02 -4.0998e+00 -2.3173e+00 -4.0392e+00 -1.0099e+00 -4.5316e-02 4.2822e-03 1.9667e-05 8.2967e-02 1.9695e-02 1.9041e-01 8.8729e-02 9.1832e-01 8.3666e-02 1.0056e+00 8.1484e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 334: 1.0251e+02 -4.0998e+00 -2.3179e+00 -4.0394e+00 -1.0097e+00 -4.4740e-02 4.2668e-03 1.9593e-05 8.3055e-02 1.9702e-02 1.9058e-01 8.8853e-02 9.1799e-01 8.3687e-02 1.0056e+00 8.1457e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 335: 1.0251e+02 -4.0998e+00 -2.3181e+00 -4.0395e+00 -1.0095e+00 -4.4451e-02 4.2558e-03 1.9535e-05 8.3023e-02 1.9762e-02 1.9027e-01 8.9035e-02 9.1828e-01 8.3673e-02 1.0052e+00 8.1469e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 336: 1.0251e+02 -4.0998e+00 -2.3178e+00 -4.0395e+00 -1.0098e+00 -4.4500e-02 4.2571e-03 1.9546e-05 8.3051e-02 1.9779e-02 1.9024e-01 8.9486e-02 9.1868e-01 8.3611e-02 1.0053e+00 8.1515e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 337: 1.0251e+02 -4.0998e+00 -2.3179e+00 -4.0396e+00 -1.0099e+00 -4.4018e-02 4.2494e-03 1.9584e-05 8.3206e-02 1.9764e-02 1.9011e-01 8.9643e-02 9.1871e-01 8.3659e-02 1.0056e+00 8.1531e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 338: 1.0251e+02 -4.0998e+00 -2.3180e+00 -4.0396e+00 -1.0101e+00 -4.3768e-02 4.2332e-03 1.9635e-05 8.3235e-02 1.9751e-02 1.9011e-01 8.9877e-02 9.1939e-01 8.3622e-02 1.0060e+00 8.1528e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 339: 1.0251e+02 -4.0998e+00 -2.3186e+00 -4.0397e+00 -1.0098e+00 -4.3605e-02 4.2237e-03 1.9638e-05 8.3611e-02 1.9725e-02 1.9014e-01 8.9946e-02 9.2025e-01 8.3580e-02 1.0064e+00 8.1528e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 340: 1.0251e+02 -4.0998e+00 -2.3190e+00 -4.0396e+00 -1.0097e+00 -4.3585e-02 4.2095e-03 1.9630e-05 8.3986e-02 1.9677e-02 1.9019e-01 8.9920e-02 9.2124e-01 8.3559e-02 1.0073e+00 8.1516e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 341: 1.0251e+02 -4.0998e+00 -2.3191e+00 -4.0398e+00 -1.0097e+00 -4.3238e-02 4.1994e-03 1.9636e-05 8.4311e-02 1.9683e-02 1.9023e-01 8.9809e-02 9.2179e-01 8.3517e-02 1.0079e+00 8.1498e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 342: 1.0251e+02 -4.0998e+00 -2.3194e+00 -4.0400e+00 -1.0097e+00 -4.2748e-02 4.1886e-03 1.9661e-05 8.4345e-02 1.9684e-02 1.9018e-01 8.9600e-02 9.2207e-01 8.3517e-02 1.0081e+00 8.1517e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 343: 1.0251e+02 -4.0998e+00 -2.3196e+00 -4.0402e+00 -1.0096e+00 -4.2336e-02 4.1813e-03 1.9615e-05 8.4331e-02 1.9666e-02 1.9016e-01 8.9379e-02 9.2231e-01 8.3534e-02 1.0083e+00 8.1548e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 344: 1.0251e+02 -4.0998e+00 -2.3197e+00 -4.0403e+00 -1.0097e+00 -4.2462e-02 4.1751e-03 1.9621e-05 8.4176e-02 1.9673e-02 1.8996e-01 8.9217e-02 9.2236e-01 8.3540e-02 1.0083e+00 8.1557e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 345: 1.0251e+02 -4.0998e+00 -2.3200e+00 -4.0403e+00 -1.0098e+00 -4.2327e-02 4.1705e-03 1.9552e-05 8.4159e-02 1.9684e-02 1.9017e-01 8.8957e-02 9.2232e-01 8.3511e-02 1.0085e+00 8.1566e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 346: 1.0251e+02 -4.0998e+00 -2.3200e+00 -4.0403e+00 -1.0097e+00 -4.2261e-02 4.1750e-03 1.9564e-05 8.4080e-02 1.9731e-02 1.9047e-01 8.8630e-02 9.2248e-01 8.3516e-02 1.0081e+00 8.1578e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 347: 1.0251e+02 -4.0999e+00 -2.3200e+00 -4.0403e+00 -1.0096e+00 -4.2296e-02 4.1883e-03 1.9634e-05 8.4231e-02 1.9747e-02 1.9061e-01 8.8399e-02 9.2250e-01 8.3557e-02 1.0075e+00 8.1580e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 348: 1.0251e+02 -4.0999e+00 -2.3199e+00 -4.0404e+00 -1.0096e+00 -4.2345e-02 4.2129e-03 1.9692e-05 8.4295e-02 1.9719e-02 1.9068e-01 8.8210e-02 9.2212e-01 8.3568e-02 1.0075e+00 8.1586e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 349: 1.0251e+02 -4.0999e+00 -2.3198e+00 -4.0404e+00 -1.0095e+00 -4.2617e-02 4.2066e-03 1.9720e-05 8.4289e-02 1.9731e-02 1.9054e-01 8.8147e-02 9.2185e-01 8.3565e-02 1.0070e+00 8.1590e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 350: 1.0251e+02 -4.0999e+00 -2.3196e+00 -4.0405e+00 -1.0093e+00 -4.2582e-02 4.2011e-03 1.9760e-05 8.4302e-02 1.9703e-02 1.9044e-01 8.8068e-02 9.2182e-01 8.3537e-02 1.0070e+00 8.1590e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 351: 1.0251e+02 -4.0998e+00 -2.3198e+00 -4.0405e+00 -1.0093e+00 -4.2377e-02 4.1970e-03 1.9750e-05 8.4587e-02 1.9708e-02 1.9045e-01 8.8008e-02 9.2169e-01 8.3507e-02 1.0067e+00 8.1584e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 352: 1.0251e+02 -4.0998e+00 -2.3201e+00 -4.0405e+00 -1.0091e+00 -4.2159e-02 4.1973e-03 1.9819e-05 8.4804e-02 1.9678e-02 1.9040e-01 8.7894e-02 9.2113e-01 8.3528e-02 1.0061e+00 8.1554e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 353: 1.0251e+02 -4.0998e+00 -2.3202e+00 -4.0405e+00 -1.0088e+00 -4.2123e-02 4.1968e-03 1.9855e-05 8.4945e-02 1.9634e-02 1.9049e-01 8.7941e-02 9.2108e-01 8.3500e-02 1.0058e+00 8.1548e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 354: 1.0251e+02 -4.0998e+00 -2.3204e+00 -4.0404e+00 -1.0087e+00 -4.2217e-02 4.1918e-03 1.9909e-05 8.5122e-02 1.9565e-02 1.9055e-01 8.7948e-02 9.2088e-01 8.3523e-02 1.0059e+00 8.1530e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 355: 1.0251e+02 -4.0998e+00 -2.3206e+00 -4.0404e+00 -1.0086e+00 -4.2057e-02 4.1853e-03 1.9973e-05 8.5389e-02 1.9505e-02 1.9057e-01 8.8109e-02 9.2100e-01 8.3496e-02 1.0058e+00 8.1520e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 356: 1.0251e+02 -4.0998e+00 -2.3209e+00 -4.0403e+00 -1.0084e+00 -4.1880e-02 4.1796e-03 2.0058e-05 8.5446e-02 1.9451e-02 1.9063e-01 8.7944e-02 9.2086e-01 8.3483e-02 1.0061e+00 8.1488e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 357: 1.0251e+02 -4.0998e+00 -2.3210e+00 -4.0404e+00 -1.0084e+00 -4.1565e-02 4.1858e-03 2.0131e-05 8.5481e-02 1.9391e-02 1.9072e-01 8.7879e-02 9.2119e-01 8.3465e-02 1.0066e+00 8.1468e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 358: 1.0251e+02 -4.0998e+00 -2.3213e+00 -4.0404e+00 -1.0084e+00 -4.1497e-02 4.1826e-03 2.0168e-05 8.5661e-02 1.9361e-02 1.9086e-01 8.7635e-02 9.2095e-01 8.3475e-02 1.0069e+00 8.1445e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 359: 1.0251e+02 -4.0997e+00 -2.3212e+00 -4.0405e+00 -1.0083e+00 -4.1127e-02 4.1993e-03 2.0188e-05 8.5904e-02 1.9347e-02 1.9078e-01 8.7558e-02 9.2087e-01 8.3451e-02 1.0068e+00 8.1461e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 360: 1.0251e+02 -4.0997e+00 -2.3215e+00 -4.0405e+00 -1.0082e+00 -4.0919e-02 4.2006e-03 2.0173e-05 8.6133e-02 1.9333e-02 1.9071e-01 8.7479e-02 9.2061e-01 8.3439e-02 1.0067e+00 8.1453e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 361: 1.0251e+02 -4.0997e+00 -2.3218e+00 -4.0406e+00 -1.0084e+00 -4.0317e-02 4.2013e-03 2.0253e-05 8.6558e-02 1.9351e-02 1.9075e-01 8.7309e-02 9.2060e-01 8.3425e-02 1.0069e+00 8.1464e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 362: 1.0251e+02 -4.0997e+00 -2.3221e+00 -4.0407e+00 -1.0086e+00 -3.9991e-02 4.2004e-03 2.0305e-05 8.6952e-02 1.9369e-02 1.9077e-01 8.7106e-02 9.2037e-01 8.3462e-02 1.0072e+00 8.1464e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 363: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0407e+00 -1.0086e+00 -3.9745e-02 4.1920e-03 2.0350e-05 8.7210e-02 1.9373e-02 1.9095e-01 8.6967e-02 9.2025e-01 8.3462e-02 1.0070e+00 8.1489e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 364: 1.0251e+02 -4.0997e+00 -2.3225e+00 -4.0407e+00 -1.0088e+00 -3.9585e-02 4.1826e-03 2.0355e-05 8.7449e-02 1.9353e-02 1.9099e-01 8.7119e-02 9.2081e-01 8.3468e-02 1.0070e+00 8.1514e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 365: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0407e+00 -1.0088e+00 -3.9531e-02 4.1781e-03 2.0298e-05 8.7646e-02 1.9346e-02 1.9083e-01 8.6997e-02 9.2106e-01 8.3455e-02 1.0068e+00 8.1546e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 366: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0407e+00 -1.0088e+00 -3.9436e-02 4.1805e-03 2.0301e-05 8.7772e-02 1.9354e-02 1.9074e-01 8.7057e-02 9.2118e-01 8.3426e-02 1.0064e+00 8.1555e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 367: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0408e+00 -1.0088e+00 -3.9172e-02 4.1791e-03 2.0368e-05 8.7914e-02 1.9333e-02 1.9063e-01 8.6948e-02 9.2106e-01 8.3409e-02 1.0060e+00 8.1558e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 368: 1.0251e+02 -4.0997e+00 -2.3222e+00 -4.0410e+00 -1.0088e+00 -3.8640e-02 4.1857e-03 2.0343e-05 8.7937e-02 1.9334e-02 1.9051e-01 8.6857e-02 9.2143e-01 8.3379e-02 1.0058e+00 8.1564e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 369: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0411e+00 -1.0088e+00 -3.8331e-02 4.1862e-03 2.0309e-05 8.7933e-02 1.9319e-02 1.9046e-01 8.6689e-02 9.2126e-01 8.3410e-02 1.0053e+00 8.1559e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 370: 1.0251e+02 -4.0997e+00 -2.3222e+00 -4.0413e+00 -1.0088e+00 -3.7984e-02 4.1921e-03 2.0301e-05 8.8082e-02 1.9313e-02 1.9050e-01 8.6622e-02 9.2101e-01 8.3424e-02 1.0049e+00 8.1559e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 371: 1.0251e+02 -4.0998e+00 -2.3222e+00 -4.0415e+00 -1.0087e+00 -3.7729e-02 4.1972e-03 2.0277e-05 8.8271e-02 1.9308e-02 1.9035e-01 8.6655e-02 9.2092e-01 8.3426e-02 1.0046e+00 8.1575e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 372: 1.0251e+02 -4.0998e+00 -2.3222e+00 -4.0414e+00 -1.0087e+00 -3.7571e-02 4.1922e-03 2.0292e-05 8.8651e-02 1.9317e-02 1.9025e-01 8.6528e-02 9.2126e-01 8.3440e-02 1.0046e+00 8.1576e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 373: 1.0251e+02 -4.0998e+00 -2.3223e+00 -4.0415e+00 -1.0087e+00 -3.7327e-02 4.1971e-03 2.0343e-05 8.8865e-02 1.9290e-02 1.9002e-01 8.6437e-02 9.2122e-01 8.3475e-02 1.0044e+00 8.1571e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 374: 1.0251e+02 -4.0998e+00 -2.3224e+00 -4.0415e+00 -1.0089e+00 -3.7275e-02 4.2072e-03 2.0450e-05 8.9078e-02 1.9306e-02 1.9002e-01 8.6224e-02 9.2111e-01 8.3480e-02 1.0047e+00 8.1569e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 375: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0415e+00 -1.0089e+00 -3.7080e-02 4.2062e-03 2.0489e-05 8.9178e-02 1.9320e-02 1.9016e-01 8.6141e-02 9.2116e-01 8.3483e-02 1.0047e+00 8.1586e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 376: 1.0251e+02 -4.0998e+00 -2.3230e+00 -4.0415e+00 -1.0089e+00 -3.7043e-02 4.2105e-03 2.0517e-05 8.9291e-02 1.9325e-02 1.9018e-01 8.6033e-02 9.2114e-01 8.3474e-02 1.0046e+00 8.1572e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 377: 1.0251e+02 -4.0998e+00 -2.3234e+00 -4.0414e+00 -1.0090e+00 -3.7302e-02 4.2097e-03 2.0524e-05 8.9438e-02 1.9333e-02 1.9012e-01 8.6018e-02 9.2123e-01 8.3476e-02 1.0046e+00 8.1545e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 378: 1.0251e+02 -4.0998e+00 -2.3234e+00 -4.0413e+00 -1.0089e+00 -3.7617e-02 4.2161e-03 2.0520e-05 8.9567e-02 1.9305e-02 1.9012e-01 8.6106e-02 9.2115e-01 8.3444e-02 1.0049e+00 8.1534e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 379: 1.0251e+02 -4.0998e+00 -2.3232e+00 -4.0412e+00 -1.0088e+00 -3.8039e-02 4.2231e-03 2.0484e-05 8.9704e-02 1.9276e-02 1.9015e-01 8.5914e-02 9.2060e-01 8.3438e-02 1.0048e+00 8.1532e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 380: 1.0251e+02 -4.0998e+00 -2.3229e+00 -4.0409e+00 -1.0088e+00 -3.8613e-02 4.2221e-03 2.0452e-05 8.9751e-02 1.9293e-02 1.9018e-01 8.5907e-02 9.2032e-01 8.3428e-02 1.0045e+00 8.1545e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 381: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.8992e-02 4.2177e-03 2.0475e-05 8.9641e-02 1.9314e-02 1.9014e-01 8.5978e-02 9.2015e-01 8.3429e-02 1.0040e+00 8.1535e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 382: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.9393e-02 4.2092e-03 2.0508e-05 8.9624e-02 1.9352e-02 1.9010e-01 8.5929e-02 9.2037e-01 8.3422e-02 1.0037e+00 8.1535e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 383: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0407e+00 -1.0089e+00 -3.9650e-02 4.2080e-03 2.0503e-05 8.9621e-02 1.9349e-02 1.9000e-01 8.5735e-02 9.2021e-01 8.3436e-02 1.0038e+00 8.1544e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 384: 1.0251e+02 -4.0998e+00 -2.3223e+00 -4.0407e+00 -1.0089e+00 -3.9709e-02 4.2111e-03 2.0489e-05 8.9690e-02 1.9347e-02 1.8985e-01 8.5516e-02 9.2025e-01 8.3420e-02 1.0037e+00 8.1541e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 385: 1.0251e+02 -4.0998e+00 -2.3225e+00 -4.0406e+00 -1.0087e+00 -3.9762e-02 4.2130e-03 2.0458e-05 8.9795e-02 1.9380e-02 1.8978e-01 8.5306e-02 9.2055e-01 8.3405e-02 1.0034e+00 8.1518e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 386: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0407e+00 -1.0087e+00 -3.9801e-02 4.2117e-03 2.0473e-05 8.9838e-02 1.9386e-02 1.8986e-01 8.5045e-02 9.2034e-01 8.3388e-02 1.0036e+00 8.1512e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 387: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.9548e-02 4.2221e-03 2.0474e-05 8.9914e-02 1.9399e-02 1.9001e-01 8.4840e-02 9.2080e-01 8.3373e-02 1.0037e+00 8.1503e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 388: 1.0251e+02 -4.0998e+00 -2.3230e+00 -4.0408e+00 -1.0088e+00 -3.9408e-02 4.2272e-03 2.0464e-05 8.9977e-02 1.9383e-02 1.9000e-01 8.4644e-02 9.2070e-01 8.3377e-02 1.0034e+00 8.1494e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 389: 1.0250e+02 -4.0998e+00 -2.3229e+00 -4.0408e+00 -1.0087e+00 -3.9326e-02 4.2285e-03 2.0459e-05 8.9927e-02 1.9366e-02 1.9001e-01 8.4485e-02 9.2063e-01 8.3367e-02 1.0032e+00 8.1487e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 390: 1.0250e+02 -4.0998e+00 -2.3231e+00 -4.0409e+00 -1.0086e+00 -3.9130e-02 4.2286e-03 2.0423e-05 8.9894e-02 1.9331e-02 1.8996e-01 8.4434e-02 9.2054e-01 8.3339e-02 1.0032e+00 8.1481e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 391: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0410e+00 -1.0086e+00 -3.8976e-02 4.2242e-03 2.0419e-05 8.9782e-02 1.9299e-02 1.8992e-01 8.4344e-02 9.2089e-01 8.3320e-02 1.0032e+00 8.1480e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 392: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0409e+00 -1.0086e+00 -3.8856e-02 4.2179e-03 2.0396e-05 8.9773e-02 1.9263e-02 1.8984e-01 8.4469e-02 9.2084e-01 8.3309e-02 1.0034e+00 8.1489e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 393: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0409e+00 -1.0089e+00 -3.8820e-02 4.2135e-03 2.0375e-05 8.9746e-02 1.9259e-02 1.8972e-01 8.4731e-02 9.2088e-01 8.3310e-02 1.0031e+00 8.1481e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 394: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0410e+00 -1.0089e+00 -3.8759e-02 4.2123e-03 2.0382e-05 8.9791e-02 1.9271e-02 1.8958e-01 8.5075e-02 9.2064e-01 8.3316e-02 1.0028e+00 8.1483e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 395: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0410e+00 -1.0090e+00 -3.8565e-02 4.2179e-03 2.0420e-05 8.9844e-02 1.9279e-02 1.8948e-01 8.5286e-02 9.2070e-01 8.3311e-02 1.0027e+00 8.1499e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 396: 1.0250e+02 -4.0998e+00 -2.3233e+00 -4.0411e+00 -1.0092e+00 -3.8505e-02 4.2207e-03 2.0445e-05 8.9863e-02 1.9281e-02 1.8944e-01 8.5452e-02 9.2053e-01 8.3326e-02 1.0028e+00 8.1524e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 397: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0411e+00 -1.0093e+00 -3.8366e-02 4.2115e-03 2.0410e-05 8.9792e-02 1.9287e-02 1.8938e-01 8.5649e-02 9.2063e-01 8.3351e-02 1.0034e+00 8.1519e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 398: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0411e+00 -1.0093e+00 -3.8179e-02 4.2049e-03 2.0362e-05 8.9718e-02 1.9281e-02 1.8943e-01 8.5813e-02 9.2065e-01 8.3391e-02 1.0040e+00 8.1513e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 399: 1.0250e+02 -4.0998e+00 -2.3236e+00 -4.0411e+00 -1.0093e+00 -3.8020e-02 4.2015e-03 2.0320e-05 8.9743e-02 1.9283e-02 1.8934e-01 8.5899e-02 9.2056e-01 8.3426e-02 1.0045e+00 8.1500e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 400: 1.0250e+02 -4.0998e+00 -2.3237e+00 -4.0412e+00 -1.0093e+00 -3.7796e-02 4.2017e-03 2.0296e-05 8.9684e-02 1.9297e-02 1.8932e-01 8.5849e-02 9.2107e-01 8.3413e-02 1.0051e+00 8.1502e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 401: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0413e+00 -1.0093e+00 -3.7697e-02 4.1959e-03 2.0275e-05 8.9618e-02 1.9291e-02 1.8914e-01 8.5796e-02 9.2086e-01 8.3480e-02 1.0051e+00 8.1510e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 402: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0414e+00 -1.0093e+00 -3.7639e-02 4.1863e-03 2.0273e-05 8.9522e-02 1.9285e-02 1.8898e-01 8.5723e-02 9.2041e-01 8.3534e-02 1.0053e+00 8.1520e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 403: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0415e+00 -1.0093e+00 -3.7634e-02 4.1878e-03 2.0250e-05 8.9456e-02 1.9288e-02 1.8895e-01 8.5791e-02 9.1990e-01 8.3549e-02 1.0055e+00 8.1545e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 404: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0416e+00 -1.0094e+00 -3.7581e-02 4.1854e-03 2.0292e-05 8.9326e-02 1.9326e-02 1.8902e-01 8.5928e-02 9.2016e-01 8.3542e-02 1.0053e+00 8.1565e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 405: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0094e+00 -3.7740e-02 4.1804e-03 2.0333e-05 8.9304e-02 1.9334e-02 1.8892e-01 8.6225e-02 9.1978e-01 8.3559e-02 1.0052e+00 8.1588e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 406: 1.0250e+02 -4.0999e+00 -2.3241e+00 -4.0415e+00 -1.0093e+00 -3.7837e-02 4.1866e-03 2.0375e-05 8.9281e-02 1.9322e-02 1.8906e-01 8.6421e-02 9.1972e-01 8.3556e-02 1.0051e+00 8.1596e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 407: 1.0250e+02 -4.0999e+00 -2.3240e+00 -4.0415e+00 -1.0092e+00 -3.8211e-02 4.1948e-03 2.0335e-05 8.9117e-02 1.9303e-02 1.8913e-01 8.6644e-02 9.1975e-01 8.3592e-02 1.0052e+00 8.1594e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 408: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0091e+00 -3.8144e-02 4.2081e-03 2.0320e-05 8.9057e-02 1.9287e-02 1.8912e-01 8.6825e-02 9.1992e-01 8.3572e-02 1.0054e+00 8.1577e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 409: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0092e+00 -3.8261e-02 4.2186e-03 2.0295e-05 8.9007e-02 1.9339e-02 1.8923e-01 8.6869e-02 9.1991e-01 8.3568e-02 1.0053e+00 8.1578e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 410: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0414e+00 -1.0093e+00 -3.8478e-02 4.2150e-03 2.0311e-05 8.9089e-02 1.9427e-02 1.8939e-01 8.7036e-02 9.2050e-01 8.3537e-02 1.0051e+00 8.1581e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 411: 1.0250e+02 -4.0999e+00 -2.3238e+00 -4.0413e+00 -1.0092e+00 -3.8732e-02 4.2116e-03 2.0289e-05 8.9015e-02 1.9467e-02 1.8939e-01 8.7005e-02 9.2025e-01 8.3538e-02 1.0049e+00 8.1581e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 412: 1.0250e+02 -4.0999e+00 -2.3238e+00 -4.0413e+00 -1.0092e+00 -3.8793e-02 4.2085e-03 2.0295e-05 8.9020e-02 1.9477e-02 1.8946e-01 8.7080e-02 9.2047e-01 8.3532e-02 1.0049e+00 8.1575e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 413: 1.0250e+02 -4.0999e+00 -2.3236e+00 -4.0412e+00 -1.0093e+00 -3.8937e-02 4.2069e-03 2.0288e-05 8.9121e-02 1.9495e-02 1.8939e-01 8.7203e-02 9.2043e-01 8.3528e-02 1.0046e+00 8.1581e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 414: 1.0250e+02 -4.0999e+00 -2.3233e+00 -4.0412e+00 -1.0093e+00 -3.9068e-02 4.2065e-03 2.0272e-05 8.9126e-02 1.9508e-02 1.8939e-01 8.7485e-02 9.2038e-01 8.3517e-02 1.0046e+00 8.1589e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 415: 1.0250e+02 -4.0999e+00 -2.3234e+00 -4.0412e+00 -1.0092e+00 -3.9299e-02 4.2117e-03 2.0277e-05 8.8971e-02 1.9564e-02 1.8955e-01 8.7734e-02 9.2051e-01 8.3502e-02 1.0048e+00 8.1575e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 416: 1.0250e+02 -4.0999e+00 -2.3232e+00 -4.0413e+00 -1.0092e+00 -3.9575e-02 4.2122e-03 2.0269e-05 8.8909e-02 1.9609e-02 1.8954e-01 8.7910e-02 9.2061e-01 8.3488e-02 1.0045e+00 8.1561e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 417: 1.0250e+02 -4.0999e+00 -2.3228e+00 -4.0412e+00 -1.0092e+00 -3.9794e-02 4.2133e-03 2.0289e-05 8.8845e-02 1.9606e-02 1.8949e-01 8.8036e-02 9.2065e-01 8.3481e-02 1.0047e+00 8.1558e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 418: 1.0250e+02 -4.0999e+00 -2.3226e+00 -4.0412e+00 -1.0092e+00 -4.0019e-02 4.2209e-03 2.0279e-05 8.8864e-02 1.9618e-02 1.8939e-01 8.8094e-02 9.2062e-01 8.3490e-02 1.0044e+00 8.1566e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 419: 1.0250e+02 -4.0999e+00 -2.3225e+00 -4.0411e+00 -1.0092e+00 -4.0090e-02 4.2242e-03 2.0258e-05 8.9089e-02 1.9644e-02 1.8924e-01 8.8285e-02 9.2082e-01 8.3484e-02 1.0040e+00 8.1567e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 420: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0410e+00 -1.0091e+00 -4.0260e-02 4.2298e-03 2.0249e-05 8.9215e-02 1.9640e-02 1.8919e-01 8.8683e-02 9.2127e-01 8.3454e-02 1.0041e+00 8.1564e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 421: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0410e+00 -1.0090e+00 -4.0359e-02 4.2292e-03 2.0289e-05 8.9366e-02 1.9642e-02 1.8928e-01 8.8905e-02 9.2154e-01 8.3452e-02 1.0038e+00 8.1572e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 422: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0410e+00 -1.0088e+00 -4.0380e-02 4.2311e-03 2.0289e-05 8.9318e-02 1.9636e-02 1.8934e-01 8.9025e-02 9.2137e-01 8.3486e-02 1.0039e+00 8.1562e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 423: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0411e+00 -1.0088e+00 -4.0256e-02 4.2283e-03 2.0277e-05 8.9324e-02 1.9645e-02 1.8923e-01 8.9305e-02 9.2129e-01 8.3484e-02 1.0038e+00 8.1565e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 424: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0412e+00 -1.0088e+00 -4.0075e-02 4.2333e-03 2.0245e-05 8.9193e-02 1.9657e-02 1.8914e-01 8.9480e-02 9.2122e-01 8.3487e-02 1.0039e+00 8.1587e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 425: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0413e+00 -1.0088e+00 -3.9950e-02 4.2360e-03 2.0257e-05 8.9170e-02 1.9644e-02 1.8924e-01 8.9622e-02 9.2104e-01 8.3492e-02 1.0042e+00 8.1599e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 426: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0413e+00 -1.0088e+00 -3.9789e-02 4.2376e-03 2.0245e-05 8.9143e-02 1.9654e-02 1.8917e-01 8.9791e-02 9.2100e-01 8.3514e-02 1.0039e+00 8.1607e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 427: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0414e+00 -1.0087e+00 -3.9766e-02 4.2469e-03 2.0228e-05 8.9102e-02 1.9656e-02 1.8913e-01 9.0076e-02 9.2110e-01 8.3499e-02 1.0037e+00 8.1607e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 428: 1.0250e+02 -4.0998e+00 -2.3225e+00 -4.0414e+00 -1.0088e+00 -3.9662e-02 4.2522e-03 2.0205e-05 8.9151e-02 1.9669e-02 1.8912e-01 9.0312e-02 9.2102e-01 8.3483e-02 1.0036e+00 8.1599e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 429: 1.0250e+02 -4.0998e+00 -2.3225e+00 -4.0414e+00 -1.0089e+00 -3.9547e-02 4.2615e-03 2.0187e-05 8.9103e-02 1.9681e-02 1.8907e-01 9.0576e-02 9.2082e-01 8.3488e-02 1.0035e+00 8.1592e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 430: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0414e+00 -1.0088e+00 -3.9593e-02 4.2613e-03 2.0159e-05 8.9075e-02 1.9692e-02 1.8894e-01 9.0762e-02 9.2073e-01 8.3487e-02 1.0035e+00 8.1603e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 431: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0413e+00 -1.0088e+00 -3.9929e-02 4.2668e-03 2.0112e-05 8.8982e-02 1.9682e-02 1.8901e-01 9.0997e-02 9.2043e-01 8.3487e-02 1.0036e+00 8.1604e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 432: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0413e+00 -1.0088e+00 -4.0182e-02 4.2693e-03 2.0089e-05 8.8860e-02 1.9659e-02 1.8898e-01 9.1110e-02 9.2024e-01 8.3490e-02 1.0036e+00 8.1585e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 433: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0412e+00 -1.0088e+00 -4.0415e-02 4.2706e-03 2.0081e-05 8.8670e-02 1.9650e-02 1.8899e-01 9.1199e-02 9.1999e-01 8.3485e-02 1.0036e+00 8.1587e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 434: 1.0250e+02 -4.0998e+00 -2.3220e+00 -4.0412e+00 -1.0087e+00 -4.0405e-02 4.2661e-03 2.0060e-05 8.8576e-02 1.9667e-02 1.8897e-01 9.1180e-02 9.1998e-01 8.3468e-02 1.0034e+00 8.1594e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 435: 1.0250e+02 -4.0998e+00 -2.3218e+00 -4.0413e+00 -1.0087e+00 -4.0471e-02 4.2639e-03 2.0050e-05 8.8450e-02 1.9671e-02 1.8891e-01 9.1156e-02 9.1970e-01 8.3469e-02 1.0033e+00 8.1602e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 436: 1.0250e+02 -4.0998e+00 -2.3216e+00 -4.0413e+00 -1.0086e+00 -4.0478e-02 4.2614e-03 2.0025e-05 8.8470e-02 1.9677e-02 1.8892e-01 9.1234e-02 9.1948e-01 8.3484e-02 1.0033e+00 8.1608e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 437: 1.0250e+02 -4.0998e+00 -2.3214e+00 -4.0413e+00 -1.0086e+00 -4.0648e-02 4.2569e-03 2.0021e-05 8.8378e-02 1.9694e-02 1.8896e-01 9.1289e-02 9.1946e-01 8.3486e-02 1.0034e+00 8.1608e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 438: 1.0250e+02 -4.0998e+00 -2.3214e+00 -4.0413e+00 -1.0085e+00 -4.0807e-02 4.2559e-03 2.0029e-05 8.8244e-02 1.9704e-02 1.8898e-01 9.1352e-02 9.1920e-01 8.3494e-02 1.0034e+00 8.1604e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 439: 1.0250e+02 -4.0998e+00 -2.3215e+00 -4.0413e+00 -1.0084e+00 -4.0814e-02 4.2472e-03 2.0035e-05 8.8064e-02 1.9736e-02 1.8905e-01 9.1469e-02 9.1900e-01 8.3510e-02 1.0032e+00 8.1602e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 440: 1.0250e+02 -4.0998e+00 -2.3216e+00 -4.0414e+00 -1.0084e+00 -4.0845e-02 4.2385e-03 2.0044e-05 8.7953e-02 1.9775e-02 1.8906e-01 9.1482e-02 9.1902e-01 8.3529e-02 1.0029e+00 8.1605e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 441: 1.0250e+02 -4.0998e+00 -2.3218e+00 -4.0415e+00 -1.0084e+00 -4.0561e-02 4.2293e-03 2.0096e-05 8.7978e-02 1.9848e-02 1.8914e-01 9.1431e-02 9.1890e-01 8.3545e-02 1.0026e+00 8.1618e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 442: 1.0250e+02 -4.0998e+00 -2.3219e+00 -4.0415e+00 -1.0085e+00 -4.0297e-02 4.2190e-03 2.0140e-05 8.8016e-02 1.9884e-02 1.8912e-01 9.1373e-02 9.1910e-01 8.3556e-02 1.0025e+00 8.1632e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 443: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0415e+00 -1.0086e+00 -4.0124e-02 4.2172e-03 2.0182e-05 8.8183e-02 1.9921e-02 1.8920e-01 9.1354e-02 9.1928e-01 8.3555e-02 1.0023e+00 8.1646e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 444: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0084e+00 -4.0120e-02 4.2226e-03 2.0208e-05 8.8142e-02 1.9980e-02 1.8916e-01 9.1269e-02 9.1934e-01 8.3540e-02 1.0020e+00 8.1653e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 445: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0083e+00 -4.0180e-02 4.2279e-03 2.0283e-05 8.8188e-02 2.0009e-02 1.8925e-01 9.1096e-02 9.1924e-01 8.3538e-02 1.0017e+00 8.1644e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 446: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0417e+00 -1.0084e+00 -4.0083e-02 4.2373e-03 2.0357e-05 8.8255e-02 2.0030e-02 1.8937e-01 9.0921e-02 9.1921e-01 8.3535e-02 1.0015e+00 8.1652e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 447: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0417e+00 -1.0083e+00 -4.0032e-02 4.2591e-03 2.0418e-05 8.8322e-02 2.0055e-02 1.8931e-01 9.0741e-02 9.1928e-01 8.3527e-02 1.0011e+00 8.1662e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 448: 1.0250e+02 -4.0999e+00 -2.3224e+00 -4.0417e+00 -1.0083e+00 -4.0042e-02 4.2759e-03 2.0499e-05 8.8372e-02 2.0083e-02 1.8935e-01 9.0554e-02 9.1942e-01 8.3524e-02 1.0010e+00 8.1661e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 449: 1.0250e+02 -4.0999e+00 -2.3224e+00 -4.0417e+00 -1.0083e+00 -4.0219e-02 4.2779e-03 2.0525e-05 8.8377e-02 2.0104e-02 1.8937e-01 9.0424e-02 9.1970e-01 8.3510e-02 1.0009e+00 8.1654e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 450: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0084e+00 -4.0390e-02 4.2779e-03 2.0520e-05 8.8387e-02 2.0120e-02 1.8939e-01 9.0277e-02 9.1991e-01 8.3489e-02 1.0010e+00 8.1662e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 451: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0085e+00 -4.0403e-02 4.2785e-03 2.0554e-05 8.8442e-02 2.0130e-02 1.8934e-01 9.0032e-02 9.2001e-01 8.3485e-02 1.0011e+00 8.1676e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 452: 1.0250e+02 -4.0999e+00 -2.3220e+00 -4.0415e+00 -1.0084e+00 -4.0503e-02 4.2730e-03 2.0537e-05 8.8507e-02 2.0135e-02 1.8926e-01 8.9777e-02 9.2031e-01 8.3473e-02 1.0013e+00 8.1671e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 453: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0084e+00 -4.0716e-02 4.2650e-03 2.0525e-05 8.8565e-02 2.0168e-02 1.8921e-01 8.9653e-02 9.2030e-01 8.3473e-02 1.0010e+00 8.1665e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 454: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0083e+00 -4.0900e-02 4.2583e-03 2.0505e-05 8.8572e-02 2.0194e-02 1.8912e-01 8.9524e-02 9.2039e-01 8.3457e-02 1.0009e+00 8.1658e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 455: 1.0250e+02 -4.0999e+00 -2.3220e+00 -4.0415e+00 -1.0083e+00 -4.0930e-02 4.2524e-03 2.0495e-05 8.8643e-02 2.0246e-02 1.8914e-01 8.9416e-02 9.2035e-01 8.3454e-02 1.0006e+00 8.1655e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 456: 1.0250e+02 -4.0999e+00 -2.3218e+00 -4.0414e+00 -1.0084e+00 -4.1008e-02 4.2455e-03 2.0482e-05 8.8831e-02 2.0290e-02 1.8904e-01 8.9438e-02 9.2042e-01 8.3448e-02 1.0005e+00 8.1672e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 457: 1.0250e+02 -4.0999e+00 -2.3216e+00 -4.0414e+00 -1.0085e+00 -4.1073e-02 4.2376e-03 2.0479e-05 8.8831e-02 2.0310e-02 1.8893e-01 8.9411e-02 9.2049e-01 8.3438e-02 1.0005e+00 8.1677e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 458: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0085e+00 -4.1036e-02 4.2288e-03 2.0479e-05 8.8894e-02 2.0311e-02 1.8879e-01 8.9378e-02 9.2055e-01 8.3419e-02 1.0006e+00 8.1689e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 459: 1.0250e+02 -4.0999e+00 -2.3216e+00 -4.0414e+00 -1.0085e+00 -4.1084e-02 4.2296e-03 2.0472e-05 8.8976e-02 2.0290e-02 1.8876e-01 8.9365e-02 9.2056e-01 8.3404e-02 1.0007e+00 8.1678e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 460: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0084e+00 -4.1065e-02 4.2257e-03 2.0473e-05 8.8978e-02 2.0254e-02 1.8871e-01 8.9287e-02 9.2061e-01 8.3386e-02 1.0007e+00 8.1663e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 461: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0084e+00 -4.1142e-02 4.2254e-03 2.0441e-05 8.8952e-02 2.0238e-02 1.8864e-01 8.9236e-02 9.2067e-01 8.3359e-02 1.0007e+00 8.1670e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 462: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0413e+00 -1.0083e+00 -4.1199e-02 4.2230e-03 2.0409e-05 8.9161e-02 2.0235e-02 1.8852e-01 8.9179e-02 9.2070e-01 8.3339e-02 1.0005e+00 8.1686e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 463: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0413e+00 -1.0084e+00 -4.1131e-02 4.2191e-03 2.0397e-05 8.9356e-02 2.0251e-02 1.8850e-01 8.9138e-02 9.2098e-01 8.3308e-02 1.0003e+00 8.1688e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 464: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0084e+00 -4.0937e-02 4.2187e-03 2.0395e-05 8.9553e-02 2.0237e-02 1.8848e-01 8.9097e-02 9.2108e-01 8.3293e-02 1.0001e+00 8.1684e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 465: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0086e+00 -4.0873e-02 4.2226e-03 2.0374e-05 8.9675e-02 2.0210e-02 1.8854e-01 8.9045e-02 9.2115e-01 8.3282e-02 1.0002e+00 8.1678e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 466: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0085e+00 -4.1046e-02 4.2312e-03 2.0379e-05 8.9703e-02 2.0232e-02 1.8852e-01 8.9031e-02 9.2100e-01 8.3294e-02 9.9982e-01 8.1665e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 467: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0414e+00 -1.0086e+00 -4.1081e-02 4.2382e-03 2.0421e-05 8.9802e-02 2.0266e-02 1.8851e-01 8.9175e-02 9.2124e-01 8.3271e-02 9.9943e-01 8.1671e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 468: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0085e+00 -4.1107e-02 4.2412e-03 2.0446e-05 8.9937e-02 2.0281e-02 1.8857e-01 8.9238e-02 9.2125e-01 8.3255e-02 9.9912e-01 8.1659e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 469: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0414e+00 -1.0084e+00 -4.1269e-02 4.2380e-03 2.0449e-05 8.9938e-02 2.0285e-02 1.8867e-01 8.9378e-02 9.2144e-01 8.3225e-02 9.9906e-01 8.1651e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 470: 1.0250e+02 -4.0999e+00 -2.3212e+00 -4.0413e+00 -1.0083e+00 -4.1552e-02 4.2384e-03 2.0437e-05 8.9924e-02 2.0280e-02 1.8878e-01 8.9520e-02 9.2149e-01 8.3205e-02 9.9880e-01 8.1648e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 471: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0412e+00 -1.0082e+00 -4.2096e-02 4.2375e-03 2.0433e-05 8.9875e-02 2.0267e-02 1.8880e-01 8.9608e-02 9.2149e-01 8.3221e-02 9.9869e-01 8.1642e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 472: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0411e+00 -1.0081e+00 -4.2380e-02 4.2446e-03 2.0435e-05 8.9823e-02 2.0262e-02 1.8885e-01 8.9602e-02 9.2156e-01 8.3233e-02 9.9868e-01 8.1643e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 473: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0410e+00 -1.0080e+00 -4.2522e-02 4.2486e-03 2.0429e-05 8.9793e-02 2.0231e-02 1.8877e-01 8.9608e-02 9.2177e-01 8.3210e-02 9.9901e-01 8.1637e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 474: 1.0250e+02 -4.0999e+00 -2.3209e+00 -4.0410e+00 -1.0079e+00 -4.2640e-02 4.2536e-03 2.0403e-05 8.9731e-02 2.0213e-02 1.8876e-01 8.9632e-02 9.2177e-01 8.3192e-02 9.9942e-01 8.1632e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 475: 1.0250e+02 -4.0999e+00 -2.3208e+00 -4.0409e+00 -1.0079e+00 -4.2882e-02 4.2576e-03 2.0375e-05 8.9666e-02 2.0190e-02 1.8866e-01 8.9718e-02 9.2160e-01 8.3218e-02 9.9931e-01 8.1622e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 476: 1.0250e+02 -4.0999e+00 -2.3207e+00 -4.0409e+00 -1.0080e+00 -4.2983e-02 4.2599e-03 2.0368e-05 8.9563e-02 2.0171e-02 1.8859e-01 8.9777e-02 9.2162e-01 8.3236e-02 9.9932e-01 8.1620e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 477: 1.0250e+02 -4.0999e+00 -2.3205e+00 -4.0410e+00 -1.0081e+00 -4.3022e-02 4.2570e-03 2.0364e-05 8.9440e-02 2.0166e-02 1.8860e-01 8.9785e-02 9.2171e-01 8.3236e-02 9.9940e-01 8.1633e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 478: 1.0250e+02 -4.0999e+00 -2.3203e+00 -4.0410e+00 -1.0080e+00 -4.3129e-02 4.2505e-03 2.0371e-05 8.9374e-02 2.0151e-02 1.8859e-01 8.9826e-02 9.2171e-01 8.3224e-02 9.9970e-01 8.1620e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 479: 1.0250e+02 -4.1000e+00 -2.3201e+00 -4.0410e+00 -1.0080e+00 -4.3186e-02 4.2440e-03 2.0373e-05 8.9355e-02 2.0133e-02 1.8858e-01 8.9837e-02 9.2168e-01 8.3214e-02 9.9991e-01 8.1621e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 480: 1.0250e+02 -4.1000e+00 -2.3198e+00 -4.0410e+00 -1.0080e+00 -4.3477e-02 4.2424e-03 2.0440e-05 8.9311e-02 2.0121e-02 1.8857e-01 8.9848e-02 9.2158e-01 8.3221e-02 9.9995e-01 8.1627e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 481: 1.0250e+02 -4.1000e+00 -2.3194e+00 -4.0410e+00 -1.0079e+00 -4.3647e-02 4.2358e-03 2.0479e-05 8.9315e-02 2.0096e-02 1.8851e-01 8.9865e-02 9.2159e-01 8.3197e-02 1.0002e+00 8.1642e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 482: 1.0250e+02 -4.1000e+00 -2.3188e+00 -4.0409e+00 -1.0079e+00 -4.3909e-02 4.2370e-03 2.0551e-05 8.9382e-02 2.0085e-02 1.8840e-01 8.9799e-02 9.2147e-01 8.3229e-02 1.0001e+00 8.1656e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 483: 1.0250e+02 -4.1000e+00 -2.3189e+00 -4.0409e+00 -1.0078e+00 -4.4169e-02 4.2467e-03 2.0587e-05 8.9377e-02 2.0054e-02 1.8838e-01 8.9943e-02 9.2130e-01 8.3237e-02 1.0003e+00 8.1650e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 484: 1.0250e+02 -4.1000e+00 -2.3188e+00 -4.0408e+00 -1.0078e+00 -4.4346e-02 4.2627e-03 2.0605e-05 8.9450e-02 2.0020e-02 1.8840e-01 9.0090e-02 9.2114e-01 8.3237e-02 1.0004e+00 8.1639e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 485: 1.0250e+02 -4.1000e+00 -2.3185e+00 -4.0408e+00 -1.0079e+00 -4.4414e-02 4.2737e-03 2.0594e-05 8.9541e-02 1.9999e-02 1.8842e-01 9.0237e-02 9.2116e-01 8.3227e-02 1.0004e+00 8.1641e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 486: 1.0250e+02 -4.1000e+00 -2.3183e+00 -4.0408e+00 -1.0080e+00 -4.4572e-02 4.2902e-03 2.0581e-05 8.9733e-02 1.9978e-02 1.8837e-01 9.0412e-02 9.2098e-01 8.3224e-02 1.0003e+00 8.1642e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 487: 1.0250e+02 -4.1000e+00 -2.3182e+00 -4.0407e+00 -1.0081e+00 -4.4698e-02 4.2979e-03 2.0560e-05 8.9822e-02 1.9954e-02 1.8827e-01 9.0744e-02 9.2114e-01 8.3212e-02 1.0003e+00 8.1644e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 488: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0081e+00 -4.4892e-02 4.3035e-03 2.0549e-05 8.9849e-02 1.9928e-02 1.8816e-01 9.1000e-02 9.2118e-01 8.3206e-02 1.0003e+00 8.1644e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 489: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0081e+00 -4.5037e-02 4.2987e-03 2.0515e-05 8.9843e-02 1.9906e-02 1.8815e-01 9.1260e-02 9.2116e-01 8.3190e-02 1.0001e+00 8.1633e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 490: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0405e+00 -1.0081e+00 -4.5139e-02 4.2930e-03 2.0508e-05 8.9827e-02 1.9887e-02 1.8814e-01 9.1545e-02 9.2114e-01 8.3178e-02 9.9991e-01 8.1624e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 491: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0405e+00 -1.0081e+00 -4.5107e-02 4.2871e-03 2.0490e-05 8.9765e-02 1.9855e-02 1.8814e-01 9.1702e-02 9.2089e-01 8.3179e-02 9.9986e-01 8.1624e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 492: 1.0250e+02 -4.1000e+00 -2.3178e+00 -4.0405e+00 -1.0080e+00 -4.5192e-02 4.2818e-03 2.0470e-05 8.9791e-02 1.9831e-02 1.8810e-01 9.1846e-02 9.2086e-01 8.3164e-02 9.9977e-01 8.1630e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 493: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0406e+00 -1.0078e+00 -4.4968e-02 4.2782e-03 2.0452e-05 8.9797e-02 1.9804e-02 1.8806e-01 9.1987e-02 9.2080e-01 8.3146e-02 9.9982e-01 8.1627e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 494: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0078e+00 -4.4773e-02 4.2766e-03 2.0453e-05 8.9696e-02 1.9781e-02 1.8805e-01 9.2096e-02 9.2057e-01 8.3148e-02 9.9999e-01 8.1611e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 495: 1.0250e+02 -4.1000e+00 -2.3181e+00 -4.0408e+00 -1.0078e+00 -4.4647e-02 4.2798e-03 2.0446e-05 8.9661e-02 1.9763e-02 1.8804e-01 9.2155e-02 9.2039e-01 8.3137e-02 9.9999e-01 8.1599e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 496: 1.0250e+02 -4.1000e+00 -2.3182e+00 -4.0408e+00 -1.0079e+00 -4.4482e-02 4.2851e-03 2.0434e-05 8.9630e-02 1.9750e-02 1.8796e-01 9.2258e-02 9.2042e-01 8.3124e-02 1.0000e+00 8.1601e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 497: 1.0250e+02 -4.1000e+00 -2.3184e+00 -4.0409e+00 -1.0079e+00 -4.4175e-02 4.2866e-03 2.0423e-05 8.9656e-02 1.9743e-02 1.8789e-01 9.2225e-02 9.2017e-01 8.3126e-02 1.0002e+00 8.1616e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 498: 1.0250e+02 -4.1000e+00 -2.3187e+00 -4.0409e+00 -1.0079e+00 -4.3826e-02 4.2847e-03 2.0406e-05 8.9587e-02 1.9730e-02 1.8781e-01 9.2143e-02 9.2017e-01 8.3156e-02 1.0002e+00 8.1613e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 499: 1.0250e+02 -4.1000e+00 -2.3190e+00 -4.0409e+00 -1.0078e+00 -4.3529e-02 4.2806e-03 2.0397e-05 8.9653e-02 1.9712e-02 1.8779e-01 9.2107e-02 9.2028e-01 8.3172e-02 1.0004e+00 8.1607e-02</span> +<span class="r-out co"><span class="r-pr">#></span> 500: 1.0250e+02 -4.1000e+00 -2.3193e+00 -4.0409e+00 -1.0077e+00 -4.3241e-02 4.2787e-03 2.0390e-05 8.9759e-02 1.9689e-02 1.8773e-01 9.2021e-02 9.2029e-01 8.3203e-02 1.0006e+00 8.1613e-02</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="co"># The following takes a very long time but gives</span></span> +<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> +<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> +<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> +<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> +<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> +<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> +<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_m1 |f_parent_qlogis | log_k1 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma_low | rsd_high |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 496.69520 | 1.000 | -1.000 | -0.9393 | -0.9673 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9214 | -0.9072 | -0.9199 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9082 | -0.8909 | -0.8969 | -0.8991 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8928 | -0.8991 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 496.6952 | 100.0 | -4.100 | -0.9400 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.100 | -0.01100 | 0.7300 | 0.06700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6756 | 1.581 | 1.265 | 1.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.151 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.6952</span> | 100.0 | 0.01657 | 0.2809 | 0.09072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01657 | 0.4973 | 0.7300 | 0.06700 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6756 | 1.581 | 1.265 | 1.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.151 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -72.99 | -3.907 | -0.8109 | 0.02803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.841 | 0.006841 | -22.18 | -32.78 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.538 | -16.93 | -12.84 | -12.77 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.02 | -9.608 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1346.5436 | 1.823 | -0.9559 | -0.9301 | -0.9677 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9792 | -0.9215 | -0.6570 | -0.5501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9482 | -0.6999 | -0.7521 | -0.7551 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7234 | -0.7907 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 1346.5436 | 182.3 | -4.056 | -0.9314 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.079 | -0.01100 | 0.8213 | 0.07939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6486 | 1.883 | 1.449 | 1.317 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.728 | 1.276 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1346.5436</span> | 182.3 | 0.01732 | 0.2826 | 0.09069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01692 | 0.4972 | 0.8213 | 0.07939 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6486 | 1.883 | 1.449 | 1.317 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.728 | 1.276 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 512.48246 | 1.082 | -0.9956 | -0.9384 | -0.9674 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9979 | -0.9214 | -0.8822 | -0.8830 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9122 | -0.8718 | -0.8824 | -0.8847 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8759 | -0.8883 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 512.48246 | 108.2 | -4.096 | -0.9391 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7391 | 0.06824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6729 | 1.611 | 1.284 | 1.167 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.502 | 1.163 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 512.48246</span> | 108.2 | 0.01665 | 0.2811 | 0.09072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01661 | 0.4973 | 0.7391 | 0.06824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6729 | 1.611 | 1.284 | 1.167 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.502 | 1.163 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 495.95762 | 1.015 | -0.9992 | -0.9391 | -0.9673 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9996 | -0.9214 | -0.9027 | -0.9133 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9090 | -0.8874 | -0.8943 | -0.8965 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8898 | -0.8972 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.95762 | 101.5 | -4.099 | -0.9398 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.100 | -0.01100 | 0.7316 | 0.06722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6751 | 1.587 | 1.269 | 1.154 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.95762</span> | 101.5 | 0.01659 | 0.2809 | 0.09072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01658 | 0.4973 | 0.7316 | 0.06722 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6751 | 1.587 | 1.269 | 1.154 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.153 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.81 | -3.013 | -0.08916 | -0.3303 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.914 | 0.005472 | -23.39 | -29.38 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.465 | -17.07 | -12.49 | -12.74 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.23 | -9.735 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 495.32815 | 1.003 | -0.9984 | -0.9391 | -0.9673 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9991 | -0.9214 | -0.8962 | -0.9051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9099 | -0.8826 | -0.8908 | -0.8930 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8855 | -0.8944 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 495.32815 | 100.3 | -4.098 | -0.9398 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.099 | -0.01100 | 0.7340 | 0.06750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6745 | 1.594 | 1.273 | 1.158 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.156 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.32815</span> | 100.3 | 0.01660 | 0.2809 | 0.09073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01659 | 0.4973 | 0.7340 | 0.06750 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6745 | 1.594 | 1.273 | 1.158 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.156 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -47.70 | -3.739 | -0.6694 | -0.04580 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.870 | 0.006670 | -22.76 | -30.26 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.613 | -16.75 | -12.29 | -12.38 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.09 | -9.486 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 494.72051 | 1.016 | -0.9974 | -0.9389 | -0.9672 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9986 | -0.9214 | -0.8902 | -0.8971 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9109 | -0.8782 | -0.8876 | -0.8897 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8816 | -0.8919 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.72051 | 101.6 | -4.097 | -0.9397 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.099 | -0.01100 | 0.7362 | 0.06777 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6738 | 1.601 | 1.277 | 1.162 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.159 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.72051</span> | 101.6 | 0.01662 | 0.2810 | 0.09073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01660 | 0.4973 | 0.7362 | 0.06777 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6738 | 1.601 | 1.277 | 1.162 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.159 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.34 | -2.939 | -0.03847 | -0.3608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.945 | 0.005434 | -20.90 | -26.17 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.821 | -17.00 | -12.53 | -12.70 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.56 | -9.587 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 494.15722 | 1.003 | -0.9966 | -0.9389 | -0.9671 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9981 | -0.9214 | -0.8845 | -0.8900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9119 | -0.8736 | -0.8842 | -0.8863 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8773 | -0.8893 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 494.15722 | 100.3 | -4.097 | -0.9396 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7383 | 0.06800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6731 | 1.608 | 1.282 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.500 | 1.162 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.15722</span> | 100.3 | 0.01663 | 0.2810 | 0.09074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01660 | 0.4973 | 0.7383 | 0.06800 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6731 | 1.608 | 1.282 | 1.166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.500 | 1.162 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.36 | -3.770 | -0.7003 | -0.03307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.882 | 0.006830 | -20.02 | -28.64 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.020 | -16.49 | -12.31 | -12.33 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.87 | -9.319 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 493.49185 | 1.015 | -0.9955 | -0.9387 | -0.9671 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9975 | -0.9214 | -0.8787 | -0.8818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9128 | -0.8688 | -0.8806 | -0.8827 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8730 | -0.8866 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 493.49185 | 101.5 | -4.096 | -0.9395 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7404 | 0.06828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6725 | 1.616 | 1.286 | 1.170 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.507 | 1.165 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.49185</span> | 101.5 | 0.01665 | 0.2810 | 0.09074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01661 | 0.4973 | 0.7404 | 0.06828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6725 | 1.616 | 1.286 | 1.170 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.507 | 1.165 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.03 | -2.976 | -0.07989 | -0.3421 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.950 | 0.005619 | -20.95 | -25.58 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.377 | -16.59 | -11.95 | -12.23 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.73 | -9.398 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 492.95463 | 1.003 | -0.9946 | -0.9387 | -0.9670 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9969 | -0.9215 | -0.8725 | -0.8742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9138 | -0.8639 | -0.8771 | -0.8790 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8686 | -0.8839 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 492.95463 | 100.3 | -4.095 | -0.9394 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.097 | -0.01100 | 0.7427 | 0.06853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6718 | 1.624 | 1.291 | 1.174 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.513 | 1.168 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.95463</span> | 100.3 | 0.01666 | 0.2810 | 0.09075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01662 | 0.4973 | 0.7427 | 0.06853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6718 | 1.624 | 1.291 | 1.174 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.513 | 1.168 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.97 | -3.772 | -0.7121 | -0.02926 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.890 | 0.006985 | -18.86 | -26.85 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.866 | -16.28 | -11.70 | -11.82 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.59 | -9.132 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 492.31444 | 1.015 | -0.9935 | -0.9385 | -0.9670 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9964 | -0.9215 | -0.8668 | -0.8662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9147 | -0.8589 | -0.8735 | -0.8755 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8642 | -0.8811 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 492.31444 | 101.5 | -4.094 | -0.9393 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.096 | -0.01100 | 0.7448 | 0.06880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6712 | 1.632 | 1.295 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.520 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.31444</span> | 101.5 | 0.01668 | 0.2810 | 0.09075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01663 | 0.4972 | 0.7448 | 0.06880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6712 | 1.632 | 1.295 | 1.178 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.520 | 1.172 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.47 | -2.944 | -0.07505 | -0.3464 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.962 | 0.005707 | -18.58 | -22.75 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.454 | -16.50 | -11.93 | -12.14 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.04 | -9.193 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 491.79472 | 1.003 | -0.9926 | -0.9385 | -0.9669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9957 | -0.9215 | -0.8609 | -0.8590 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9158 | -0.8537 | -0.8697 | -0.8716 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8594 | -0.8781 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.79472 | 100.3 | -4.093 | -0.9392 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.096 | -0.01100 | 0.7469 | 0.06904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6705 | 1.640 | 1.300 | 1.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.175 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.79472</span> | 100.3 | 0.01670 | 0.2811 | 0.09076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01664 | 0.4972 | 0.7469 | 0.06904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6705 | 1.640 | 1.300 | 1.183 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.175 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.84 | -3.756 | -0.7183 | -0.02810 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.902 | 0.007122 | -19.51 | -25.13 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.711 | -16.03 | -11.73 | -11.80 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.28 | -8.965 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 491.12641 | 1.014 | -0.9913 | -0.9383 | -0.9669 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9951 | -0.9215 | -0.8546 | -0.8511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9167 | -0.8483 | -0.8658 | -0.8677 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8546 | -0.8752 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 491.12641 | 101.4 | -4.091 | -0.9390 | -2.400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.095 | -0.01100 | 0.7492 | 0.06931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6699 | 1.648 | 1.305 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.534 | 1.178 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.12641</span> | 101.4 | 0.01672 | 0.2811 | 0.09076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01665 | 0.4972 | 0.7492 | 0.06931 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6699 | 1.648 | 1.305 | 1.187 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.534 | 1.178 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.57 | -2.950 | -0.1076 | -0.3310 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.967 | 0.005897 | -18.06 | -21.71 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.154 | -16.24 | -11.62 | -11.87 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.73 | -8.995 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 490.65951 | 1.002 | -0.9903 | -0.9382 | -0.9668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9944 | -0.9215 | -0.8485 | -0.8438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9178 | -0.8429 | -0.8619 | -0.8637 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8496 | -0.8721 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.65951 | 100.2 | -4.090 | -0.9390 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.094 | -0.01100 | 0.7514 | 0.06955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6692 | 1.657 | 1.310 | 1.192 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.541 | 1.182 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.65951</span> | 100.2 | 0.01673 | 0.2811 | 0.09077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01667 | 0.4972 | 0.7514 | 0.06955 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6692 | 1.657 | 1.310 | 1.192 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.541 | 1.182 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.76 | -3.759 | -0.7472 | -0.01668 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.908 | 0.007323 | -16.70 | -21.90 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.094 | -15.72 | -11.38 | -11.47 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.04 | -8.745 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 490.01300 | 1.014 | -0.9891 | -0.9380 | -0.9667 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9937 | -0.9215 | -0.8428 | -0.8366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9189 | -0.8372 | -0.8579 | -0.8596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8446 | -0.8690 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 490.013 | 101.4 | -4.089 | -0.9388 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.094 | -0.01100 | 0.7535 | 0.06979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6684 | 1.666 | 1.315 | 1.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.549 | 1.186 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.013</span> | 101.4 | 0.01676 | 0.2811 | 0.09077 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01668 | 0.4972 | 0.7535 | 0.06979 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6684 | 1.666 | 1.315 | 1.196 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.549 | 1.186 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.25 | -2.890 | -0.09666 | -0.3362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.973 | 0.006003 | -17.09 | -20.19 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.007 | -15.95 | -11.25 | -11.56 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.42 | -8.788 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 489.51603 | 1.003 | -0.9880 | -0.9380 | -0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9930 | -0.9215 | -0.8366 | -0.8294 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9200 | -0.8313 | -0.8537 | -0.8553 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8392 | -0.8658 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 489.51603 | 100.3 | -4.088 | -0.9388 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.093 | -0.01100 | 0.7558 | 0.07003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6677 | 1.675 | 1.320 | 1.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.556 | 1.189 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.51603</span> | 100.3 | 0.01677 | 0.2812 | 0.09078 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01669 | 0.4972 | 0.7558 | 0.07003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6677 | 1.675 | 1.320 | 1.201 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.556 | 1.189 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -45.29 | -3.673 | -0.7179 | -0.03084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.907 | 0.007423 | -17.34 | -21.86 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.565 | -15.52 | -11.05 | -11.19 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.28 | -8.545 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 488.89410 | 1.014 | -0.9866 | -0.9377 | -0.9666 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9922 | -0.9215 | -0.8304 | -0.8220 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9210 | -0.8254 | -0.8495 | -0.8510 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8337 | -0.8625 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.8941 | 101.4 | -4.087 | -0.9385 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.092 | -0.01100 | 0.7580 | 0.07028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6670 | 1.685 | 1.325 | 1.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.565 | 1.193 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.8941</span> | 101.4 | 0.01680 | 0.2812 | 0.09079 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01670 | 0.4972 | 0.7580 | 0.07028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6670 | 1.685 | 1.325 | 1.206 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.565 | 1.193 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 32.56 | -2.827 | -0.09853 | -0.3366 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.968 | 0.006143 | -15.42 | -18.16 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.733 | -15.52 | -10.94 | -11.25 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.13 | -8.583 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 488.48678 | 1.002 | -0.9855 | -0.9377 | -0.9664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9915 | -0.9215 | -0.8246 | -0.8152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9220 | -0.8195 | -0.8454 | -0.8468 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8284 | -0.8593 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 488.48678 | 100.2 | -4.086 | -0.9385 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.091 | -0.01100 | 0.7601 | 0.07051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 1.694 | 1.331 | 1.211 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.572 | 1.197 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.48678</span> | 100.2 | 0.01681 | 0.2812 | 0.09080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01671 | 0.4972 | 0.7601 | 0.07051 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 1.694 | 1.331 | 1.211 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.572 | 1.197 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.86 | -3.681 | -0.7723 |-0.0007467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.892 | 0.007742 | -16.40 | -20.55 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.306 | -15.16 | -10.65 | -10.82 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.00 | -8.331 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 487.81394 | 1.012 | -0.9841 | -0.9374 | -0.9664 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9907 | -0.9215 | -0.8186 | -0.8083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9229 | -0.8132 | -0.8411 | -0.8424 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8225 | -0.8558 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.81394 | 101.2 | -4.084 | -0.9383 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.091 | -0.01100 | 0.7623 | 0.07074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6657 | 1.704 | 1.336 | 1.216 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.581 | 1.201 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.81394</span> | 101.2 | 0.01684 | 0.2812 | 0.09080 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01673 | 0.4972 | 0.7623 | 0.07074 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6657 | 1.704 | 1.336 | 1.216 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.581 | 1.201 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.73 | -2.818 | -0.1513 | -0.3103 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.952 | 0.006413 | -14.43 | -16.89 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.774 | -15.21 | -10.56 | -10.91 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.80 | -8.354 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 487.41354 | 1.002 | -0.9829 | -0.9374 | -0.9663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9898 | -0.9215 | -0.8126 | -0.8013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9240 | -0.8068 | -0.8367 | -0.8378 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8167 | -0.8523 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 487.41354 | 100.2 | -4.083 | -0.9382 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.090 | -0.01100 | 0.7645 | 0.07098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6649 | 1.714 | 1.342 | 1.221 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.590 | 1.205 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.41354</span> | 100.2 | 0.01686 | 0.2813 | 0.09082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01674 | 0.4972 | 0.7645 | 0.07098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6649 | 1.714 | 1.342 | 1.221 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.590 | 1.205 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.04 | -3.605 | -0.7738 | -0.005231 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.885 | 0.007887 | -13.75 | -19.14 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.153 | -14.90 | -10.33 | -10.54 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.68 | -8.125 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 486.77105 | 1.012 | -0.9814 | -0.9371 | -0.9662 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9889 | -0.9215 | -0.8076 | -0.7947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9250 | -0.7999 | -0.8321 | -0.8330 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8104 | -0.8486 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 486.77105 | 101.2 | -4.081 | -0.9380 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.089 | -0.01100 | 0.7664 | 0.07119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6643 | 1.725 | 1.347 | 1.227 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.599 | 1.209 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.77105</span> | 101.2 | 0.01688 | 0.2813 | 0.09082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01676 | 0.4972 | 0.7664 | 0.07119 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6643 | 1.725 | 1.347 | 1.227 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.599 | 1.209 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.27 | -2.713 | -0.1438 | -0.3142 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.939 | 0.006562 | -14.18 | -16.12 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.525 | -14.86 | -10.17 | -10.57 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.46 | -8.131 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 486.40106 | 1.002 | -0.9802 | -0.9371 | -0.9661 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9881 | -0.9215 | -0.8015 | -0.7878 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9261 | -0.7935 | -0.8277 | -0.8285 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8046 | -0.8452 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 486.40106 | 100.2 | -4.080 | -0.9379 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.088 | -0.01100 | 0.7686 | 0.07143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6635 | 1.735 | 1.353 | 1.232 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.608 | 1.213 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.40106</span> | 100.2 | 0.01690 | 0.2813 | 0.09083 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01677 | 0.4972 | 0.7686 | 0.07143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6635 | 1.735 | 1.353 | 1.232 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.608 | 1.213 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.43 | -3.533 | -0.7907 | 0.002583 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.861 | 0.008122 | -12.85 | -17.77 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.313 | -14.52 | -9.868 | -10.18 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.34 | -7.899 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 485.77865 | 1.012 | -0.9786 | -0.9368 | -0.9660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9871 | -0.9215 | -0.7966 | -0.7818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9271 | -0.7864 | -0.8231 | -0.8237 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7980 | -0.8414 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.77865 | 101.2 | -4.079 | -0.9376 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.087 | -0.01100 | 0.7704 | 0.07163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6629 | 1.746 | 1.359 | 1.238 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.617 | 1.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.77865</span> | 101.2 | 0.01693 | 0.2814 | 0.09084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01679 | 0.4972 | 0.7704 | 0.07163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6629 | 1.746 | 1.359 | 1.238 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.617 | 1.217 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.77 | -2.587 | -0.1355 | -0.3176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.913 | 0.006717 | -13.39 | -15.00 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.211 | -14.53 | -9.747 | -10.22 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.16 | -7.915 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 485.42886 | 1.002 | -0.9775 | -0.9367 | -0.9659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9862 | -0.9215 | -0.7907 | -0.7751 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9281 | -0.7799 | -0.8187 | -0.8190 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7921 | -0.8378 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 485.42886 | 100.2 | -4.077 | -0.9376 | -2.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.086 | -0.01100 | 0.7725 | 0.07185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6622 | 1.757 | 1.364 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.626 | 1.221 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.42886</span> | 100.2 | 0.01695 | 0.2814 | 0.09085 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01680 | 0.4972 | 0.7725 | 0.07185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6622 | 1.757 | 1.364 | 1.243 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.626 | 1.221 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.95 | -3.431 | -0.7980 | 0.007511 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.828 | 0.008340 | -12.05 | -16.59 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.177 | -14.27 | -9.567 | -9.843 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.98 | -7.655 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 484.82183 | 1.012 | -0.9759 | -0.9364 | -0.9658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9852 | -0.9215 | -0.7861 | -0.7697 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9290 | -0.7723 | -0.8141 | -0.8141 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 | -0.8339 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.82183 | 101.2 | -4.076 | -0.9373 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.085 | -0.01100 | 0.7742 | 0.07203 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6616 | 1.769 | 1.370 | 1.249 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.636 | 1.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.82183</span> | 101.2 | 0.01698 | 0.2814 | 0.09086 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01682 | 0.4972 | 0.7742 | 0.07203 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6616 | 1.769 | 1.370 | 1.249 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.636 | 1.226 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.05 | -2.460 | -0.1372 | -0.3150 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.875 | 0.006918 | -12.51 | -13.87 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.059 | -14.26 | -9.441 | -9.910 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.81 | -7.688 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 484.49026 | 1.002 | -0.9747 | -0.9363 | -0.9656 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9843 | -0.9215 | -0.7802 | -0.7632 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9300 | -0.7655 | -0.8095 | -0.8093 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7791 | -0.8302 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 484.49026 | 100.2 | -4.075 | -0.9372 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.084 | -0.01100 | 0.7764 | 0.07225 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6609 | 1.779 | 1.376 | 1.254 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.645 | 1.230 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.49026</span> | 100.2 | 0.01700 | 0.2815 | 0.09087 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01684 | 0.4972 | 0.7764 | 0.07225 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6609 | 1.779 | 1.376 | 1.254 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.645 | 1.230 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.40 | -3.314 | -0.8046 | 0.01082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.785 | 0.008564 | -11.34 | -13.90 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.095 | -13.95 | -9.157 | -9.483 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.66 | -7.448 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 483.91316 | 1.012 | -0.9731 | -0.9360 | -0.9656 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9832 | -0.9215 | -0.7758 | -0.7593 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9309 | -0.7575 | -0.8048 | -0.8042 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7719 | -0.8261 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.91316 | 101.2 | -4.073 | -0.9369 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.083 | -0.01100 | 0.7780 | 0.07238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6603 | 1.792 | 1.382 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.656 | 1.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.91316</span> | 101.2 | 0.01702 | 0.2815 | 0.09088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01685 | 0.4972 | 0.7780 | 0.07238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6603 | 1.792 | 1.382 | 1.260 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.656 | 1.235 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.71 | -2.295 | -0.1241 | -0.3190 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.824 | 0.007081 | -13.14 | -14.20 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.713 | -13.92 | -9.049 | -9.560 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.44 | -7.439 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 483.53972 | 1.003 | -0.9719 | -0.9359 | -0.9654 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9822 | -0.9215 | -0.7695 | -0.7529 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9317 | -0.7501 | -0.8002 | -0.7993 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7653 | -0.8222 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.53972 | 100.3 | -4.072 | -0.9368 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.082 | -0.01100 | 0.7803 | 0.07259 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6598 | 1.804 | 1.388 | 1.266 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.666 | 1.239 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.53972</span> | 100.3 | 0.01705 | 0.2815 | 0.09089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01687 | 0.4972 | 0.7803 | 0.07259 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6598 | 1.804 | 1.388 | 1.266 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.666 | 1.239 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -41.33 | -3.086 | -0.7421 | -0.01550 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.732 | 0.008667 | -12.24 | -14.31 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.879 | -13.57 | -8.704 | -9.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.31 | -7.231 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 483.02129 | 1.012 | -0.9704 | -0.9356 | -0.9653 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9811 | -0.9215 | -0.7639 | -0.7482 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9323 | -0.7422 | -0.7957 | -0.7943 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7582 | -0.8182 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 483.02129 | 101.2 | -4.070 | -0.9365 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.081 | -0.01100 | 0.7823 | 0.07275 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6594 | 1.816 | 1.393 | 1.271 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.676 | 1.244 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.02129</span> | 101.2 | 0.01707 | 0.2816 | 0.09090 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01689 | 0.4972 | 0.7823 | 0.07275 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6594 | 1.816 | 1.393 | 1.271 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.676 | 1.244 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.99 | -2.064 | -0.07177 | -0.3414 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.768 | 0.007186 | -12.35 | -13.09 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | -13.63 | -8.749 | -9.199 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.40 | -7.209 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 482.63111 | 1.003 | -0.9692 | -0.9355 | -0.9651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9800 | -0.9215 | -0.7579 | -0.7429 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9329 | -0.7344 | -0.7911 | -0.7893 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7510 | -0.8142 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.63111 | 100.3 | -4.069 | -0.9364 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.080 | -0.01100 | 0.7845 | 0.07293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6589 | 1.829 | 1.399 | 1.277 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.687 | 1.249 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.63111</span> | 100.3 | 0.01709 | 0.2816 | 0.09092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01691 | 0.4972 | 0.7845 | 0.07293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6589 | 1.829 | 1.399 | 1.277 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.687 | 1.249 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.55 | -2.873 | -0.6941 | -0.03251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.664 | 0.008820 | -11.56 | -13.31 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.468 | -13.22 | -8.319 | -8.815 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.93 | -7.014 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 482.15860 | 1.013 | -0.9679 | -0.9352 | -0.9650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9789 | -0.9215 | -0.7525 | -0.7387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9332 | -0.7261 | -0.7866 | -0.7843 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7435 | -0.8100 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 482.1586 | 101.3 | -4.068 | -0.9361 | -2.398 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.079 | -0.01100 | 0.7865 | 0.07307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6587 | 1.842 | 1.405 | 1.283 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.698 | 1.253 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.1586</span> | 101.3 | 0.01711 | 0.2817 | 0.09093 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01693 | 0.4972 | 0.7865 | 0.07307 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6587 | 1.842 | 1.405 | 1.283 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.698 | 1.253 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.18 | -1.853 | -0.03641 | -0.3540 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.697 | 0.007343 | -10.35 | -10.94 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.762 | -13.15 | -8.194 | -8.841 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.73 | -7.013 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 481.77253 | 1.004 | -0.9667 | -0.9350 | -0.9648 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9778 | -0.9215 | -0.7477 | -0.7350 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9339 | -0.7174 | -0.7818 | -0.7789 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7358 | -0.8055 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.77253 | 100.4 | -4.067 | -0.9360 | -2.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.078 | -0.01100 | 0.7882 | 0.07320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6583 | 1.855 | 1.411 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.709 | 1.259 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.77253</span> | 100.4 | 0.01713 | 0.2817 | 0.09095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01695 | 0.4972 | 0.7882 | 0.07320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6583 | 1.855 | 1.411 | 1.289 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.709 | 1.259 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.42 | -2.468 | -0.6588 | -0.04495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.582 | 0.009000 | -9.278 | -10.93 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.073 | -12.89 | -7.995 | -8.451 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.53 | -6.784 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 481.33405 | 1.012 | -0.9656 | -0.9347 | -0.9646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9766 | -0.9215 | -0.7446 | -0.7329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9352 | -0.7079 | -0.7769 | -0.7733 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7275 | -0.8008 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 481.33405 | 101.2 | -4.066 | -0.9357 | -2.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.077 | -0.01100 | 0.7894 | 0.07326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6574 | 1.870 | 1.417 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.721 | 1.264 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.33405</span> | 101.2 | 0.01715 | 0.2818 | 0.09096 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01697 | 0.4972 | 0.7894 | 0.07326 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6574 | 1.870 | 1.417 | 1.296 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.721 | 1.264 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.32 | -1.710 | -0.03967 | -0.3452 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.599 | 0.007614 | -9.890 | -10.44 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | -12.78 | -7.841 | -8.441 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.31 | -6.748 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 480.95912 | 1.004 | -0.9646 | -0.9346 | -0.9644 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9754 | -0.9215 | -0.7406 | -0.7300 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | -0.6985 | -0.7720 | -0.7677 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7193 | -0.7960 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.95912 | 100.4 | -4.065 | -0.9356 | -2.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.075 | -0.01100 | 0.7908 | 0.07336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 1.885 | 1.424 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.734 | 1.270 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.95912</span> | 100.4 | 0.01717 | 0.2818 | 0.09098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01699 | 0.4972 | 0.7908 | 0.07336 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 1.885 | 1.424 | 1.302 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.734 | 1.270 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.38 | -2.273 | -0.6168 | -0.05646 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.481 | 0.009185 | -8.899 | -11.86 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | -12.49 | -7.578 | -8.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.13 | -6.546 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 480.53887 | 1.012 | -0.9637 | -0.9342 | -0.9642 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9743 | -0.9216 | -0.7379 | -0.7267 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9369 | -0.6888 | -0.7673 | -0.7623 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7109 | -0.7912 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.53887 | 101.2 | -4.064 | -0.9352 | -2.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.074 | -0.01100 | 0.7918 | 0.07347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.901 | 1.429 | 1.308 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.746 | 1.275 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.53887</span> | 101.2 | 0.01719 | 0.2819 | 0.09100 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01700 | 0.4972 | 0.7918 | 0.07347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.901 | 1.429 | 1.308 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.746 | 1.275 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.40 | -1.545 | -0.009684 | -0.3499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.497 | 0.007817 | -10.78 | -11.16 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.267 | -12.36 | -7.423 | -8.042 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.90 | -6.497 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 480.15983 | 1.005 | -0.9631 | -0.9341 | -0.9640 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9733 | -0.9216 | -0.7332 | -0.7223 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9371 | -0.6793 | -0.7629 | -0.7571 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7029 | -0.7866 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.15983 | 100.5 | -4.063 | -0.9351 | -2.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.073 | -0.01100 | 0.7935 | 0.07362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6561 | 1.916 | 1.435 | 1.314 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.758 | 1.280 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.15983</span> | 100.5 | 0.01720 | 0.2819 | 0.09102 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01702 | 0.4972 | 0.7935 | 0.07362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6561 | 1.916 | 1.435 | 1.314 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.758 | 1.280 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.57 | -2.381 | -0.5845 | -0.05882 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.378 | 0.009420 | -9.960 | -11.12 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.408 | -12.08 | -7.201 | -7.708 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.66 | -6.274 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 479.76525 | 1.013 | -0.9621 | -0.9338 | -0.9638 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9724 | -0.9216 | -0.7274 | -0.7189 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9370 | -0.6698 | -0.7590 | -0.7523 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6950 | -0.7821 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.76525 | 101.3 | -4.062 | -0.9349 | -2.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.072 | -0.01100 | 0.7956 | 0.07373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.931 | 1.440 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.770 | 1.286 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.76525</span> | 101.3 | 0.01721 | 0.2819 | 0.09104 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01704 | 0.4972 | 0.7956 | 0.07373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.931 | 1.440 | 1.320 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.770 | 1.286 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 25.60 | -1.145 | 0.04744 | -0.3638 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.405 | 0.007969 | -8.937 | -9.159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | -11.97 | -7.076 | -7.721 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.46 | -6.241 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 479.40619 | 1.005 | -0.9617 | -0.9337 | -0.9635 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9714 | -0.9216 | -0.7231 | -0.7171 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6597 | -0.7546 | -0.7470 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6867 | -0.7774 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.40619 | 100.5 | -4.062 | -0.9348 | -2.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.071 | -0.01100 | 0.7972 | 0.07380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.947 | 1.445 | 1.326 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.782 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.40619</span> | 100.5 | 0.01722 | 0.2820 | 0.09107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01705 | 0.4972 | 0.7972 | 0.07380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.947 | 1.445 | 1.326 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.782 | 1.291 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.68 | -2.255 | -0.5492 | -0.06756 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.289 | 0.009576 | -8.071 | -10.65 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.114 | -11.68 | -6.840 | -7.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.30 | -6.055 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 479.03445 | 1.012 | -0.9610 | -0.9335 | -0.9633 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9705 | -0.9216 | -0.7212 | -0.7148 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6492 | -0.7503 | -0.7416 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6779 | -0.7724 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 479.03445 | 101.2 | -4.061 | -0.9345 | -2.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.071 | -0.01100 | 0.7979 | 0.07387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.963 | 1.451 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.795 | 1.297 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.03445</span> | 101.2 | 0.01723 | 0.2820 | 0.09109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01707 | 0.4972 | 0.7979 | 0.07387 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.963 | 1.451 | 1.332 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.795 | 1.297 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.12 | -1.081 | 0.03630 | -0.3485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.311 | 0.008233 | -8.610 | -8.856 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.385 | -11.53 | -6.694 | -7.351 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.05 | -5.987 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 478.70046 | 1.005 | -0.9607 | -0.9334 | -0.9629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9697 | -0.9216 | -0.7185 | -0.7124 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9378 | -0.6386 | -0.7461 | -0.7363 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6692 | -0.7674 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.70046 | 100.5 | -4.061 | -0.9345 | -2.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.070 | -0.01100 | 0.7989 | 0.07395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 1.980 | 1.456 | 1.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.808 | 1.302 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.70046</span> | 100.5 | 0.01724 | 0.2820 | 0.09112 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01708 | 0.4972 | 0.7989 | 0.07395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 1.980 | 1.456 | 1.338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.808 | 1.302 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.51 | -2.193 | -0.5308 | -0.05813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.191 | 0.009843 | -9.246 | -10.25 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.049 | -11.25 | -6.459 | -7.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.842 | -5.790 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 478.33460 | 1.012 | -0.9602 | -0.9332 | -0.9627 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9690 | -0.9216 | -0.7136 | -0.7111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6278 | -0.7425 | -0.7314 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6607 | -0.7626 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.3346 | 101.2 | -4.060 | -0.9343 | -2.395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.069 | -0.01100 | 0.8007 | 0.07400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.997 | 1.461 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.820 | 1.308 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.3346</span> | 101.2 | 0.01724 | 0.2821 | 0.09114 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01709 | 0.4972 | 0.8007 | 0.07400 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.997 | 1.461 | 1.344 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.820 | 1.308 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 20.00 | -1.246 | 0.04282 | -0.3358 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.228 | 0.008460 | -8.250 | -8.533 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.305 | -11.09 | -6.335 | -6.999 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.637 | -5.739 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 478.02904 | 1.005 | -0.9595 | -0.9333 | -0.9623 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9683 | -0.9217 | -0.7087 | -0.7092 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9377 | -0.6173 | -0.7388 | -0.7264 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6523 | -0.7577 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 478.02904 | 100.5 | -4.060 | -0.9343 | -2.395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.068 | -0.01100 | 0.8025 | 0.07406 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 2.014 | 1.466 | 1.350 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.833 | 1.314 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.02904</span> | 100.5 | 0.01726 | 0.2820 | 0.09117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01711 | 0.4972 | 0.8025 | 0.07406 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 2.014 | 1.466 | 1.350 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.833 | 1.314 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.91 | -2.133 | -0.5430 | -0.03427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.114 | 0.01012 | -7.324 | -9.914 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9278 | -10.81 | -6.119 | -6.673 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.457 | -5.557 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 477.67480 | 1.012 | -0.9587 | -0.9331 | -0.9620 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9677 | -0.9217 | -0.7077 | -0.7075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9374 | -0.6060 | -0.7354 | -0.7215 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6433 | -0.7527 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.6748 | 101.2 | -4.059 | -0.9342 | -2.395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.068 | -0.01100 | 0.8028 | 0.07412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.032 | 1.470 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.846 | 1.319 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.6748</span> | 101.2 | 0.01727 | 0.2821 | 0.09120 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01712 | 0.4972 | 0.8028 | 0.07412 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.032 | 1.470 | 1.355 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.846 | 1.319 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 17.58 | -1.074 | 0.03251 | -0.3151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.162 | 0.008688 | -9.226 | -9.481 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9303 | -10.65 | -6.004 | -6.660 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.223 | -5.492 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 477.36674 | 1.005 | -0.9586 | -0.9332 | -0.9617 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9672 | -0.9217 | -0.7028 | -0.7029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9362 | -0.5954 | -0.7323 | -0.7170 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6350 | -0.7479 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.36674 | 100.5 | -4.059 | -0.9343 | -2.394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.067 | -0.01100 | 0.8046 | 0.07427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6567 | 2.048 | 1.474 | 1.361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.858 | 1.325 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.36674</span> | 100.5 | 0.01727 | 0.2821 | 0.09123 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01713 | 0.4972 | 0.8046 | 0.07427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6567 | 2.048 | 1.474 | 1.361 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.858 | 1.325 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.86 | -1.999 | -0.5088 | -0.02993 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.056 | 0.01029 | -6.930 | -7.943 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.123 | -10.40 | -5.776 | -6.354 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.032 | -5.321 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 477.05158 | 1.012 | -0.9583 | -0.9331 | -0.9614 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9667 | -0.9217 | -0.6985 | -0.7029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9357 | -0.5841 | -0.7296 | -0.7125 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6265 | -0.7430 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 477.05158 | 101.2 | -4.058 | -0.9342 | -2.394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.067 | -0.01100 | 0.8062 | 0.07427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.066 | 1.477 | 1.366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.871 | 1.331 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.05158</span> | 101.2 | 0.01728 | 0.2821 | 0.09126 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01713 | 0.4972 | 0.8062 | 0.07427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.066 | 1.477 | 1.366 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.871 | 1.331 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.59 | -0.9080 | 0.1072 | -0.3377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.120 | 0.008656 | -8.076 | -8.919 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8940 | -10.23 | -5.724 | -6.385 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.830 | -5.273 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 476.75116 | 1.006 | -0.9582 | -0.9333 | -0.9610 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9662 | -0.9217 | -0.6961 | -0.7025 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9353 | -0.5723 | -0.7265 | -0.7076 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6174 | -0.7378 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.75116 | 100.6 | -4.058 | -0.9343 | -2.394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.066 | -0.01100 | 0.8070 | 0.07428 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.085 | 1.481 | 1.371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.884 | 1.337 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.75116</span> | 100.6 | 0.01728 | 0.2820 | 0.09129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01714 | 0.4972 | 0.8070 | 0.07428 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.085 | 1.481 | 1.371 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.884 | 1.337 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -19.26 | -1.806 | -0.3949 | -0.06769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | 0.01017 | -6.717 | -7.715 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.115 | -9.949 | -5.529 | -6.080 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.599 | -5.083 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 476.47529 | 1.013 | -0.9577 | -0.9333 | -0.9608 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9657 | -0.9218 | -0.6941 | -0.7020 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9354 | -0.5606 | -0.7233 | -0.7027 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6086 | -0.7326 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.47529 | 101.3 | -4.058 | -0.9343 | -2.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.066 | -0.01100 | 0.8078 | 0.07430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.103 | 1.485 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.897 | 1.342 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.47529</span> | 101.3 | 0.01729 | 0.2820 | 0.09132 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01715 | 0.4972 | 0.8078 | 0.07430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.103 | 1.485 | 1.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.897 | 1.342 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.23 | -0.7393 | 0.1467 | -0.3435 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.063 | 0.008714 | -6.650 | -7.604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.072 | -9.778 | -5.421 | -6.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.413 | -5.023 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 476.20958 | 1.007 | -0.9575 | -0.9335 | -0.9604 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9651 | -0.9218 | -0.6949 | -0.7035 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | -0.5488 | -0.7198 | -0.6977 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5996 | -0.7274 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 476.20958 | 100.7 | -4.058 | -0.9345 | -2.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.065 | -0.01100 | 0.8075 | 0.07425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 2.122 | 1.490 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.910 | 1.349 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.20958</span> | 100.7 | 0.01729 | 0.2820 | 0.09135 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01716 | 0.4972 | 0.8075 | 0.07425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 2.122 | 1.490 | 1.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.910 | 1.349 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.91 | -1.652 | -0.3580 | -0.07063 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9392 | 0.01022 | -6.706 | -7.708 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9788 | -9.498 | -5.202 | -5.742 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.208 | -4.851 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 475.96032 | 1.013 | -0.9572 | -0.9335 | -0.9601 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9647 | -0.9218 | -0.6944 | -0.7034 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9370 | -0.5368 | -0.7166 | -0.6928 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5905 | -0.7221 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.96032 | 101.3 | -4.057 | -0.9346 | -2.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.065 | -0.01100 | 0.8077 | 0.07425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 2.141 | 1.494 | 1.388 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.924 | 1.355 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.96032</span> | 101.3 | 0.01730 | 0.2820 | 0.09138 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8077 | 0.07425 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 2.141 | 1.494 | 1.388 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.924 | 1.355 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.21 | -0.6469 | 0.1490 | -0.3297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9912 | 0.008804 | -6.697 | -7.730 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.011 | -9.295 | -5.014 | -5.737 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.990 | -4.768 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 475.69232 | 1.007 | -0.9579 | -0.9338 | -0.9597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9645 | -0.9219 | -0.6939 | -0.7032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9375 | -0.5243 | -0.7149 | -0.6885 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5813 | -0.7168 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.69232 | 100.7 | -4.058 | -0.9348 | -2.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01100 | 0.8078 | 0.07426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.161 | 1.496 | 1.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.937 | 1.361 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.69232</span> | 100.7 | 0.01729 | 0.2819 | 0.09141 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8078 | 0.07426 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.161 | 1.496 | 1.393 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.937 | 1.361 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.63 | -1.703 | -0.3428 | -0.06069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9074 | 0.01024 | -7.409 | -9.759 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6668 | -9.063 | -4.970 | -5.451 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.786 | -4.607 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 475.41012 | 1.012 | -0.9580 | -0.9340 | -0.9594 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9645 | -0.9219 | -0.6912 | -0.6928 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9358 | -0.5138 | -0.7150 | -0.6862 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5743 | -0.7128 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.41012 | 101.2 | -4.058 | -0.9351 | -2.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8088 | 0.07461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.177 | 1.496 | 1.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.948 | 1.365 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.41012</span> | 101.2 | 0.01728 | 0.2819 | 0.09144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8088 | 0.07461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.177 | 1.496 | 1.396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.948 | 1.365 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 17.88 | -0.8521 | 0.09625 | -0.2834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | 0.008928 | -8.320 | -8.272 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6841 | -8.896 | -4.958 | -5.482 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.690 | -4.565 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 475.17343 | 1.006 | -0.9580 | -0.9344 | -0.9592 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9643 | -0.9219 | -0.6806 | -0.6840 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9328 | -0.5062 | -0.7153 | -0.6852 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5694 | -0.7102 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 475.17343 | 100.6 | -4.058 | -0.9354 | -2.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8127 | 0.07490 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6590 | 2.189 | 1.495 | 1.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.955 | 1.368 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.17343</span> | 100.6 | 0.01728 | 0.2818 | 0.09146 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01718 | 0.4972 | 0.8127 | 0.07490 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6590 | 2.189 | 1.495 | 1.397 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.955 | 1.368 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.54 | -1.885 | -0.4332 | -0.003109 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9120 | 0.01053 | -7.129 | -7.659 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | -8.700 | -4.918 | -5.365 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.558 | -4.481 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 474.94312 | 1.012 | -0.9570 | -0.9345 | -0.9591 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9638 | -0.9220 | -0.6676 | -0.6825 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9307 | -0.4984 | -0.7146 | -0.6834 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5639 | -0.7072 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.94312 | 101.2 | -4.057 | -0.9355 | -2.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8175 | 0.07495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6604 | 2.202 | 1.496 | 1.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.963 | 1.372 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.94312</span> | 101.2 | 0.01730 | 0.2818 | 0.09147 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01718 | 0.4972 | 0.8175 | 0.07495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6604 | 2.202 | 1.496 | 1.399 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.963 | 1.372 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 20.08 | -0.5236 | 0.1181 | -0.2986 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9599 | 0.008866 | -5.310 | -6.088 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8565 | -8.707 | -4.867 | -5.430 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.458 | -4.464 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 474.70657 | 1.007 | -0.9569 | -0.9346 | -0.9588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9629 | -0.9220 | -0.6640 | -0.6851 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9296 | -0.4868 | -0.7112 | -0.6784 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5553 | -0.7021 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.70657 | 100.7 | -4.057 | -0.9356 | -2.392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8188 | 0.07487 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6612 | 2.220 | 1.500 | 1.405 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.976 | 1.378 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.70657</span> | 100.7 | 0.01730 | 0.2818 | 0.09149 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01720 | 0.4972 | 0.8188 | 0.07487 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6612 | 2.220 | 1.500 | 1.405 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.976 | 1.378 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.64 | -1.502 | -0.3627 | -0.03824 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7798 | 0.01049 | -5.965 | -8.154 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5631 | -8.385 | -4.675 | -5.151 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.306 | -4.317 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 474.46623 | 1.012 | -0.9580 | -0.9346 | -0.9586 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9630 | -0.9221 | -0.6659 | -0.6813 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9264 | -0.4751 | -0.7083 | -0.6739 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5464 | -0.6970 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.46623 | 101.2 | -4.058 | -0.9356 | -2.391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8181 | 0.07499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6633 | 2.239 | 1.504 | 1.410 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.989 | 1.384 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.46623</span> | 101.2 | 0.01728 | 0.2818 | 0.09151 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01720 | 0.4972 | 0.8181 | 0.07499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6633 | 2.239 | 1.504 | 1.410 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.989 | 1.384 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.93 | -0.7754 | 0.09266 | -0.2754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8835 | 0.009135 | -6.026 | -6.068 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8217 | -8.210 | -4.532 | -5.141 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.011 | -4.237 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 474.23394 | 1.006 | -0.9577 | -0.9351 | -0.9581 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9633 | -0.9221 | -0.6610 | -0.6793 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9234 | -0.4633 | -0.7068 | -0.6694 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5382 | -0.6917 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 474.23394 | 100.6 | -4.058 | -0.9360 | -2.391 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8199 | 0.07506 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.257 | 1.506 | 1.415 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.001 | 1.390 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.23394</span> | 100.6 | 0.01729 | 0.2817 | 0.09156 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01719 | 0.4972 | 0.8199 | 0.07506 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.257 | 1.506 | 1.415 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.001 | 1.390 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.30 | -1.703 | -0.3919 | -0.002629 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8653 | 0.01064 | -4.947 | -7.765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7818 | -8.010 | -4.437 | -4.875 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.938 | -4.094 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 473.98878 | 1.011 | -0.9542 | -0.9354 | -0.9578 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9619 | -0.9222 | -0.6621 | -0.6770 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9235 | -0.4507 | -0.7053 | -0.6648 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5298 | -0.6863 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.98878 | 101.1 | -4.054 | -0.9363 | -2.390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.062 | -0.01101 | 0.8195 | 0.07514 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6653 | 2.277 | 1.508 | 1.421 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.013 | 1.396 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.98878</span> | 101.1 | 0.01735 | 0.2816 | 0.09159 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01722 | 0.4972 | 0.8195 | 0.07514 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6653 | 2.277 | 1.508 | 1.421 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.013 | 1.396 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 473.76836 | 1.011 | -0.9500 | -0.9359 | -0.9574 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9601 | -0.9223 | -0.6653 | -0.6763 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9234 | -0.4357 | -0.7046 | -0.6601 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5205 | -0.6802 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 473.76836 | 101.1 | -4.050 | -0.9368 | -2.390 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.060 | -0.01101 | 0.8183 | 0.07516 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.301 | 1.509 | 1.426 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.027 | 1.403 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.76836</span> | 101.1 | 0.01742 | 0.2815 | 0.09163 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01725 | 0.4972 | 0.8183 | 0.07516 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.301 | 1.509 | 1.426 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.027 | 1.403 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 472.96708 | 1.009 | -0.9317 | -0.9384 | -0.9555 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9527 | -0.9228 | -0.6791 | -0.6735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9230 | -0.3711 | -0.7015 | -0.6396 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4802 | -0.6537 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.96708 | 100.9 | -4.032 | -0.9391 | -2.388 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.053 | -0.01101 | 0.8133 | 0.07525 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6656 | 2.403 | 1.513 | 1.450 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.087 | 1.433 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.96708</span> | 100.9 | 0.01774 | 0.2811 | 0.09180 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01737 | 0.4972 | 0.8133 | 0.07525 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6656 | 2.403 | 1.513 | 1.450 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.087 | 1.433 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 472.23802 | 1.005 | -0.8811 | -0.9451 | -0.9502 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9323 | -0.9240 | -0.7172 | -0.6658 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9220 | -0.1924 | -0.6930 | -0.5829 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3688 | -0.5805 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.23802 | 100.5 | -3.981 | -0.9455 | -2.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.032 | -0.01103 | 0.7994 | 0.07551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 2.686 | 1.523 | 1.515 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.251 | 1.518 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.23802</span> | 100.5 | 0.01866 | 0.2798 | 0.09228 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01773 | 0.4972 | 0.7994 | 0.07551 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 2.686 | 1.523 | 1.515 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.251 | 1.518 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.41 | 25.09 | -1.964 | 0.8913 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.956 | 0.02208 | -7.724 | -8.360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01123 | -2.619 | -3.185 | -1.886 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.376 | -1.727 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 470.34942 | 1.020 | -1.007 | -0.9408 | -0.9496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9429 | -0.9259 | -0.7397 | -0.6282 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9207 | 0.06578 | -0.6693 | -0.4998 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2002 | -0.4722 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 470.34942 | 102.0 | -4.107 | -0.9414 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.043 | -0.01105 | 0.7911 | 0.07677 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.094 | 1.553 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.34942</span> | 102.0 | 0.01646 | 0.2806 | 0.09235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01755 | 0.4972 | 0.7911 | 0.07677 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.094 | 1.553 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.94 | -17.10 | 1.872 | -1.413 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.005064 | -7.591 | -5.431 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2085 | -2.165 | -1.196 | -0.1732 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4074 | -0.2957 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 480.76065 | 0.9913 | -0.9789 | -0.9482 | -0.9314 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.207 | -0.9279 | -0.6546 | -0.4866 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9168 | 0.2296 | -0.6593 | -0.5083 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1307 | -0.4332 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 480.76065 | 99.13 | -4.079 | -0.9483 | -2.364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.307 | -0.01107 | 0.8222 | 0.08152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6698 | 3.353 | 1.566 | 1.601 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.603 | 1.687 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.76065</span> | 99.13 | 0.01693 | 0.2792 | 0.09404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01347 | 0.4972 | 0.8222 | 0.08152 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6698 | 3.353 | 1.566 | 1.601 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.603 | 1.687 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 472.12595 | 0.9860 | -0.9933 | -0.9428 | -0.9466 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9755 | -0.9261 | -0.7254 | -0.6089 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9204 | 0.08558 | -0.6674 | -0.5007 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1921 | -0.4676 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 472.12595 | 98.60 | -4.093 | -0.9433 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.076 | -0.01105 | 0.7964 | 0.07742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.125 | 1.556 | 1.609 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.512 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.12595</span> | 98.60 | 0.01668 | 0.2802 | 0.09262 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01698 | 0.4972 | 0.7964 | 0.07742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.125 | 1.556 | 1.609 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.512 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 470.26696 | 1.005 | -1.002 | -0.9414 | -0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9444 | -0.9259 | -0.7373 | -0.6265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9207 | 0.06646 | -0.6689 | -0.4998 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4721 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 470.26696 | 100.5 | -4.102 | -0.9420 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.044 | -0.01105 | 0.7920 | 0.07683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.095 | 1.554 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.26696</span> | 100.5 | 0.01654 | 0.2805 | 0.09239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01752 | 0.4972 | 0.7920 | 0.07683 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.095 | 1.554 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -57.97 | -21.53 | 0.3336 | -0.1964 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.949 | 0.01388 | -7.299 | -5.475 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3363 | -1.951 | -1.200 | 0.1716 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4705 | -0.2755 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 469.85165 | 1.014 | -0.9972 | -0.9415 | -0.9489 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9548 | -0.9260 | -0.7307 | -0.6235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9208 | 0.07069 | -0.6682 | -0.5004 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1987 | -0.4712 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.85165 | 101.4 | -4.097 | -0.9421 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01105 | 0.7944 | 0.07693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6671 | 3.101 | 1.555 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.85165</span> | 101.4 | 0.01662 | 0.2805 | 0.09241 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.7944 | 0.07693 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6671 | 3.101 | 1.555 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.302 | -15.01 | 1.055 | -0.6015 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.082 | 0.004567 | -8.090 | -5.650 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2579 | -2.336 | -1.339 | -0.08766 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5208 | -0.3062 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 469.69998 | 1.007 | -0.9853 | -0.9423 | -0.9484 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -0.9260 | -0.7231 | -0.6186 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9204 | 0.07309 | -0.6671 | -0.5006 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1982 | -0.4709 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.69998 | 100.7 | -4.085 | -0.9429 | -2.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.7972 | 0.07709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.105 | 1.556 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.69998</span> | 100.7 | 0.01682 | 0.2803 | 0.09245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.7972 | 0.07709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.105 | 1.556 | 1.610 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.86 | -12.39 | 0.1028 | 0.1354 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7614 | 0.008951 | -8.542 | -6.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2246 | -2.313 | -1.235 | 0.1010 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5654 | -0.2998 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 469.45579 | 1.013 | -0.9821 | -0.9425 | -0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9260 | -0.7099 | -0.6134 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9182 | 0.07758 | -0.6674 | -0.5042 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1996 | -0.4719 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.45579 | 101.3 | -4.082 | -0.9430 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.8020 | 0.07727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6689 | 3.112 | 1.556 | 1.605 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.45579</span> | 101.3 | 0.01687 | 0.2803 | 0.09239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8020 | 0.07727 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6689 | 3.112 | 1.556 | 1.605 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.383 | -7.976 | 0.5709 | -0.2773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4749 | 0.005686 | -7.013 | -4.742 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3037 | -2.186 | -1.089 | -0.04880 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5661 | -0.3435 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 469.35718 | 1.007 | -0.9760 | -0.9430 | -0.9493 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9561 | -0.9261 | -0.6977 | -0.6075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9166 | 0.08278 | -0.6675 | -0.5068 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4722 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.35718 | 100.7 | -4.076 | -0.9435 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.8065 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6700 | 3.121 | 1.556 | 1.602 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.35718</span> | 100.7 | 0.01698 | 0.2802 | 0.09237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8065 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6700 | 3.121 | 1.556 | 1.602 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.34 | -7.406 | -0.07810 | 0.1748 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6873 | 0.009156 | -6.696 | -4.901 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2913 | -2.170 | -1.086 | -0.02443 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6503 | -0.3607 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 469.19639 | 1.012 | -0.9749 | -0.9431 | -0.9497 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9262 | -0.6862 | -0.6021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | 0.09137 | -0.6688 | -0.5111 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2009 | -0.4726 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.19639 | 101.2 | -4.075 | -0.9436 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01105 | 0.8107 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6719 | 3.134 | 1.554 | 1.597 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.19639</span> | 101.2 | 0.01699 | 0.2802 | 0.09233 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8107 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6719 | 3.134 | 1.554 | 1.597 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.760 | -4.629 | 0.3091 | -0.1325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04401 | 0.005819 | -5.826 | -2.903 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1562 | -2.130 | -1.121 | -0.2535 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6922 | -0.4141 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 469.12263 | 1.008 | -0.9713 | -0.9434 | -0.9499 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9262 | -0.6727 | -0.6012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9123 | 0.09974 | -0.6678 | -0.5134 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2010 | -0.4726 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.12263 | 100.8 | -4.071 | -0.9438 | -2.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01105 | 0.8156 | 0.07768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6728 | 3.147 | 1.555 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.12263</span> | 100.8 | 0.01706 | 0.2801 | 0.09232 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8156 | 0.07768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6728 | 3.147 | 1.555 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.86 | -4.532 | -0.1251 | 0.1663 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1284 | 0.008177 | -5.101 | -3.487 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2183 | -2.137 | -1.171 | -0.2991 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6817 | -0.4261 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 469.02483 | 1.011 | -0.9711 | -0.9434 | -0.9500 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9263 | -0.6616 | -0.6038 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9105 | 0.1111 | -0.6656 | -0.5157 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2026 | -0.4730 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 469.02483 | 101.1 | -4.071 | -0.9439 | -2.383 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01105 | 0.8196 | 0.07759 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6741 | 3.165 | 1.558 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.641 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.02483</span> | 101.1 | 0.01706 | 0.2801 | 0.09230 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8196 | 0.07759 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6741 | 3.165 | 1.558 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.641 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.786 | -2.589 | 0.2046 | -0.1061 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1383 | 0.006373 | -4.080 | -2.588 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1418 | -1.956 | -0.9118 | -0.4226 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7530 | -0.4429 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 468.97618 | 1.009 | -0.9710 | -0.9439 | -0.9494 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9625 | -0.9265 | -0.6573 | -0.5998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9085 | 0.1255 | -0.6648 | -0.5157 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2015 | -0.4719 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.97618 | 100.9 | -4.071 | -0.9443 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01106 | 0.8212 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6755 | 3.188 | 1.559 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.97618</span> | 100.9 | 0.01706 | 0.2800 | 0.09236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01721 | 0.4972 | 0.8212 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6755 | 3.188 | 1.559 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.25 | -3.431 | -0.02518 | 0.1501 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.529 | 0.005347 | -4.655 | -3.448 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3102 | -2.013 | -0.8937 | -0.3742 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7403 | -0.4511 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 468.91299 | 1.010 | -0.9702 | -0.9444 | -0.9496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9534 | -0.9266 | -0.6524 | -0.5929 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9051 | 0.1362 | -0.6665 | -0.5172 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2029 | -0.4725 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.91299 | 101.0 | -4.070 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.053 | -0.01106 | 0.8230 | 0.07796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6777 | 3.205 | 1.557 | 1.590 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.496 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.91299</span> | 101.0 | 0.01707 | 0.2799 | 0.09234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01736 | 0.4972 | 0.8230 | 0.07796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6777 | 3.205 | 1.557 | 1.590 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.496 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -8.129 | -2.859 | -0.02802 | -0.004107 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.281 | 0.009120 | -4.291 | -2.058 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1551 | -2.052 | -1.121 | -0.5699 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7547 | -0.4743 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 471.25018 | 1.036 | -0.9607 | -0.9443 | -0.9496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9266 | -0.6382 | -0.5860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9046 | 0.1430 | -0.6628 | -0.5153 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2004 | -0.4709 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 471.25018 | 103.6 | -4.061 | -0.9447 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01106 | 0.8282 | 0.07819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6781 | 3.216 | 1.562 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 471.25018</span> | 103.6 | 0.01724 | 0.2800 | 0.09234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8282 | 0.07819 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6781 | 3.216 | 1.562 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 468.90555 | 1.012 | -0.9692 | -0.9444 | -0.9496 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9538 | -0.9266 | -0.6510 | -0.5922 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9050 | 0.1369 | -0.6661 | -0.5170 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2027 | -0.4723 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.90555 | 101.2 | -4.069 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.054 | -0.01106 | 0.8235 | 0.07798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6778 | 3.206 | 1.557 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.90555</span> | 101.2 | 0.01709 | 0.2799 | 0.09234 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01736 | 0.4972 | 0.8235 | 0.07798 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6778 | 3.206 | 1.557 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.48 | -1.027 | 0.1960 | -0.1655 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9827 | 0.007474 | -3.960 | -2.226 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2199 | -2.046 | -1.158 | -0.6171 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7493 | -0.4797 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 468.88608 | 1.010 | -0.9691 | -0.9444 | -0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9542 | -0.9266 | -0.6497 | -0.5917 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9044 | 0.1391 | -0.6659 | -0.5166 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2026 | -0.4722 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.88608 | 101.0 | -4.069 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.054 | -0.01106 | 0.8240 | 0.07799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6782 | 3.210 | 1.558 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.88608</span> | 101.0 | 0.01709 | 0.2799 | 0.09235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01735 | 0.4972 | 0.8240 | 0.07799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6782 | 3.210 | 1.558 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.784 | -1.944 | 0.009889 | -0.02065 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9781 | 0.008521 | -3.685 | -1.489 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08345 | -1.963 | -0.9408 | -0.4978 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7271 | -0.4658 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 468.87604 | 1.012 | -0.9680 | -0.9444 | -0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9547 | -0.9266 | -0.6476 | -0.5909 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9043 | 0.1402 | -0.6654 | -0.5163 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2021 | -0.4719 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.87604 | 101.2 | -4.068 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8248 | 0.07802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6783 | 3.211 | 1.558 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.87604</span> | 101.2 | 0.01711 | 0.2799 | 0.09235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8248 | 0.07802 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6783 | 3.211 | 1.558 | 1.591 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.309 | -0.5261 | 0.1314 | -0.1053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 0.007435 | -3.809 | -2.129 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2297 | -2.013 | -1.108 | -0.5855 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7533 | -0.4780 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 468.85962 | 1.010 | -0.9680 | -0.9444 | -0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9550 | -0.9266 | -0.6462 | -0.5907 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | 0.1428 | -0.6653 | -0.5160 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2020 | -0.4717 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.85962 | 101.0 | -4.068 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8253 | 0.07803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6787 | 3.215 | 1.558 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.85962</span> | 101.0 | 0.01711 | 0.2799 | 0.09235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8253 | 0.07803 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6787 | 3.215 | 1.558 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.556 | -1.258 | -0.007590 | 0.001179 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7035 | 0.008243 | -4.446 | -2.277 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2406 | -1.984 | -1.075 | -0.5476 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7588 | -0.4741 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 468.84535 | 1.011 | -0.9673 | -0.9444 | -0.9495 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9554 | -0.9266 | -0.6436 | -0.5895 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9036 | 0.1439 | -0.6647 | -0.5157 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2016 | -0.4714 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.84535 | 101.1 | -4.067 | -0.9448 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8262 | 0.07807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6788 | 3.217 | 1.559 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.84535</span> | 101.1 | 0.01712 | 0.2799 | 0.09235 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8262 | 0.07807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6788 | 3.217 | 1.559 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.130 | -0.4165 | 0.05789 | -0.04298 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5152 | 0.007618 | -4.342 | -2.024 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2412 | -1.936 | -0.8986 | -0.4874 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7551 | -0.4761 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 468.83559 | 1.009 | -0.9672 | -0.9445 | -0.9494 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9556 | -0.9266 | -0.6414 | -0.5890 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | 0.1455 | -0.6647 | -0.5153 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2012 | -0.4711 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.83559 | 100.9 | -4.067 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8270 | 0.07809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6790 | 3.220 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.83559</span> | 100.9 | 0.01713 | 0.2799 | 0.09236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8270 | 0.07809 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6790 | 3.220 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.643 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.676 | -1.212 | -0.1115 | 0.08612 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5488 | 0.008589 | -2.761 | -2.165 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2456 | -1.924 | -0.8622 | -0.4413 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7592 | -0.4720 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 468.82320 | 1.011 | -0.9670 | -0.9445 | -0.9494 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9559 | -0.9267 | -0.6401 | -0.5885 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | 0.1478 | -0.6651 | -0.5152 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2008 | -0.4708 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.8232 | 101.1 | -4.067 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8275 | 0.07810 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6795 | 3.223 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.8232</span> | 101.1 | 0.01713 | 0.2799 | 0.09236 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8275 | 0.07810 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6795 | 3.223 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.440 | -0.1810 | 0.05193 | -0.03082 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3483 | 0.007438 | -3.541 | -1.923 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2409 | -1.947 | -1.058 | -0.5469 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7518 | -0.4735 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 468.81154 | 1.010 | -0.9671 | -0.9445 | -0.9493 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9267 | -0.6389 | -0.5880 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | 0.1505 | -0.6652 | -0.5150 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2005 | -0.4704 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.81154 | 101.0 | -4.067 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8279 | 0.07812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6800 | 3.228 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.81154</span> | 101.0 | 0.01713 | 0.2799 | 0.09237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8279 | 0.07812 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6800 | 3.228 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.875 | -0.7736 | -0.05343 | 0.05244 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3113 | 0.007978 | -4.161 | -2.012 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2433 | -1.896 | -0.8853 | -0.4539 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7524 | -0.4694 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 468.80001 | 1.011 | -0.9668 | -0.9445 | -0.9493 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9563 | -0.9267 | -0.6364 | -0.5873 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9013 | 0.1522 | -0.6651 | -0.5147 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4701 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.80001 | 101.1 | -4.067 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8288 | 0.07814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6803 | 3.230 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.80001</span> | 101.1 | 0.01713 | 0.2799 | 0.09237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8288 | 0.07814 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6803 | 3.230 | 1.559 | 1.593 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.046 | 0.03721 | 0.05257 | -0.02595 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1943 | 0.007238 | -2.985 | -2.233 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3122 | -1.891 | -0.9609 | -0.5652 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8019 | -0.4712 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 468.79133 | 1.009 | -0.9669 | -0.9445 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9565 | -0.9267 | -0.6348 | -0.5869 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9006 | 0.1543 | -0.6654 | -0.5144 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1996 | -0.4698 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.79133 | 100.9 | -4.067 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8294 | 0.07816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6807 | 3.234 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.79133</span> | 100.9 | 0.01713 | 0.2799 | 0.09237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8294 | 0.07816 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6807 | 3.234 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.226 | -0.9038 | -0.1166 | 0.1039 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2475 | 0.008246 | -3.388 | -1.948 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2420 | -1.872 | -0.8620 | -0.4291 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7186 | -0.4561 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 468.77848 | 1.011 | -0.9668 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9568 | -0.9267 | -0.6338 | -0.5863 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8997 | 0.1569 | -0.6658 | -0.5142 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1992 | -0.4695 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.77848 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8298 | 0.07818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6814 | 3.238 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.502 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.77848</span> | 101.1 | 0.01713 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8298 | 0.07818 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6814 | 3.238 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.502 | 1.645 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.503 | -0.1762 | 0.005994 | 0.01651 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06327 | 0.007339 | -4.407 | -2.185 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3133 | -1.836 | -0.8110 | -0.4803 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7946 | -0.4665 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 468.76805 | 1.010 | -0.9668 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9267 | -0.6312 | -0.5853 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8993 | 0.1583 | -0.6657 | -0.5139 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1987 | -0.4691 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.76805 | 101.0 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8307 | 0.07821 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6816 | 3.240 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.76805</span> | 101.0 | 0.01713 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8307 | 0.07821 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6816 | 3.240 | 1.558 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.980 | -0.7098 | -0.1045 | 0.1001 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1097 | 0.008007 | -2.998 | -1.799 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2421 | -1.902 | -1.021 | -0.4929 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7234 | -0.4545 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 468.76178 | 1.012 | -0.9666 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9268 | -0.6296 | -0.5849 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8987 | 0.1602 | -0.6657 | -0.5136 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1982 | -0.4689 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.76178 | 101.2 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8313 | 0.07822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6820 | 3.243 | 1.558 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.76178</span> | 101.2 | 0.01714 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8313 | 0.07822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6820 | 3.243 | 1.558 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.381 | 0.4945 | 0.08709 | -0.04347 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04178 | 0.006758 | -3.785 | -1.947 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3007 | -1.819 | -0.8940 | -0.4901 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7836 | -0.4662 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 468.74724 | 1.010 | -0.9668 | -0.9447 | -0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6284 | -0.5849 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8978 | 0.1628 | -0.6658 | -0.5134 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1979 | -0.4686 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.74724 | 101.0 | -4.067 | -0.9451 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8318 | 0.07822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6827 | 3.247 | 1.558 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.74724</span> | 101.0 | 0.01713 | 0.2799 | 0.09239 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8318 | 0.07822 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6827 | 3.247 | 1.558 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.646 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.251 | -0.3146 | -0.04610 | 0.05724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.02086 | 0.007590 | -4.230 | -2.098 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3136 | -1.833 | -0.9365 | -0.5244 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7857 | -0.4618 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 468.73570 | 1.011 | -0.9666 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6257 | -0.5836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8976 | 0.1639 | -0.6652 | -0.5131 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1974 | -0.4683 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.7357 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8327 | 0.07827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6828 | 3.249 | 1.559 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.7357</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8327 | 0.07827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6828 | 3.249 | 1.559 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.473 | 0.2106 | 0.02342 | 0.003517 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03354 | 0.007130 | -3.431 | -1.904 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3114 | -1.829 | -0.9161 | -0.5352 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7806 | -0.4641 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 468.73562 | 1.009 | -0.9667 | -0.9447 | -0.9491 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6239 | -0.5826 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8973 | 0.1651 | -0.6648 | -0.5128 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1970 | -0.4681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.73562 | 100.9 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8334 | 0.07830 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.73562</span> | 100.9 | 0.01713 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8334 | 0.07830 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -12.26 | -1.176 | -0.2138 | 0.1217 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02157 | 0.008077 | -2.776 | -1.301 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1367 | -1.738 | -0.7465 | -0.4531 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7359 | -0.4611 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 468.72331 | 1.010 | -0.9665 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6235 | -0.5825 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8973 | 0.1654 | -0.6647 | -0.5127 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1969 | -0.4680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.72331 | 101.0 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8335 | 0.07831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.72331</span> | 101.0 | 0.01714 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8335 | 0.07831 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3583 | -0.08989 | -0.03828 | 0.04946 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.006154 | 0.007526 | -3.405 | -1.898 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3214 | -1.836 | -0.8751 | -0.5118 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7778 | -0.4622 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 468.71715 | 1.011 | -0.9665 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6223 | -0.5817 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8972 | 0.1661 | -0.6643 | -0.5125 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1966 | -0.4678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.71715 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8340 | 0.07833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6831 | 3.252 | 1.560 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.71715</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8340 | 0.07833 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6831 | 3.252 | 1.560 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.647 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 468.70862 | 1.011 | -0.9665 | -0.9446 | -0.9492 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6204 | -0.5807 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8970 | 0.1671 | -0.6639 | -0.5123 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1962 | -0.4676 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.70862 | 101.1 | -4.066 | -0.9450 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8347 | 0.07836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6832 | 3.254 | 1.560 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.70862</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8347 | 0.07836 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6832 | 3.254 | 1.560 | 1.596 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 468.69301 | 1.011 | -0.9664 | -0.9446 | -0.9493 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6166 | -0.5786 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8967 | 0.1691 | -0.6629 | -0.5117 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1953 | -0.4671 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.69301 | 101.1 | -4.066 | -0.9449 | -2.382 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8361 | 0.07843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6834 | 3.257 | 1.562 | 1.597 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.508 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.69301</span> | 101.1 | 0.01714 | 0.2799 | 0.09237 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8361 | 0.07843 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6834 | 3.257 | 1.562 | 1.597 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.508 | 1.648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.000 | 0.4463 | 0.03173 | -0.005614 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04729 | 0.007073 | -3.041 | -1.513 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3269 | -1.766 | -0.6347 | -0.4208 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7611 | -0.4631 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 468.66018 | 1.011 | -0.9666 | -0.9442 | -0.9484 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9269 | -0.6101 | -0.5828 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8947 | 0.1828 | -0.6704 | -0.5138 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1918 | -0.4639 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.66018 | 101.1 | -4.067 | -0.9446 | -2.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8385 | 0.07829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6847 | 3.279 | 1.552 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.513 | 1.652 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.66018</span> | 101.1 | 0.01714 | 0.2800 | 0.09245 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8385 | 0.07829 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6847 | 3.279 | 1.552 | 1.594 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.513 | 1.652 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 468.61872 | 1.011 | -0.9669 | -0.9434 | -0.9467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9547 | -0.9271 | -0.5984 | -0.5914 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8911 | 0.2086 | -0.6849 | -0.5181 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1852 | -0.4581 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.61872 | 101.1 | -4.067 | -0.9439 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8427 | 0.07801 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6872 | 3.320 | 1.534 | 1.589 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.523 | 1.658 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.61872</span> | 101.1 | 0.01713 | 0.2801 | 0.09261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8427 | 0.07801 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6872 | 3.320 | 1.534 | 1.589 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.523 | 1.658 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.484 | 0.5384 | 0.08463 | 0.09865 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7055 | 0.007848 | -2.909 | -1.559 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2162 | -1.642 | -1.728 | -0.7121 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5947 | -0.3648 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 468.58548 | 1.008 | -0.9690 | -0.9515 | -0.9524 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9418 | -0.9281 | -0.5713 | -0.6320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8823 | 0.2961 | -0.6589 | -0.5284 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1884 | -0.4503 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.58548 | 100.8 | -4.069 | -0.9515 | -2.385 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.042 | -0.01107 | 0.8526 | 0.07665 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6931 | 3.458 | 1.567 | 1.578 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.518 | 1.667 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.58548</span> | 100.8 | 0.01709 | 0.2786 | 0.09208 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01757 | 0.4972 | 0.8526 | 0.07665 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6931 | 3.458 | 1.567 | 1.578 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.518 | 1.667 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.63 | -1.258 | -0.4941 | -0.2790 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.133 | 0.01399 | -2.360 | -3.936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04374 | -1.146 | -0.2901 | -1.004 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6864 | -0.2503 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 468.42330 | 1.011 | -0.9777 | -0.9596 | -0.9476 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9583 | -0.9295 | -0.5827 | -0.6211 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8760 | 0.3979 | -0.6632 | -0.5247 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1834 | -0.4404 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.4233 | 101.1 | -4.078 | -0.9591 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8485 | 0.07701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6974 | 3.619 | 1.561 | 1.582 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.525 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.4233</span> | 101.1 | 0.01695 | 0.2771 | 0.09253 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8485 | 0.07701 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6974 | 3.619 | 1.561 | 1.582 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.525 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.203 | -3.445 | -0.3661 | -0.1876 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3413 | 0.004713 | -2.617 | -2.520 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09908 | -0.8887 | -0.1336 | -0.9981 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6593 | -0.1712 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 468.44544 | 1.015 | -0.9711 | -0.9083 | -0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9571 | -0.9308 | -0.5728 | -0.6140 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9111 | 0.4459 | -0.6774 | -0.4582 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1728 | -0.4486 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.44544 | 101.5 | -4.071 | -0.9109 | -2.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01110 | 0.8520 | 0.07725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6737 | 3.695 | 1.543 | 1.658 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.541 | 1.669 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.44544</span> | 101.5 | 0.01706 | 0.2868 | 0.09331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8520 | 0.07725 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6737 | 3.695 | 1.543 | 1.658 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.541 | 1.669 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 468.45245 | 1.016 | -0.9696 | -0.9377 | -0.9438 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9300 | -0.5745 | -0.6143 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8908 | 0.4193 | -0.6689 | -0.4955 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1780 | -0.4435 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.45245 | 101.6 | -4.070 | -0.9385 | -2.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01109 | 0.8514 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6874 | 3.653 | 1.554 | 1.615 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.533 | 1.675 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.45245</span> | 101.6 | 0.01708 | 0.2812 | 0.09288 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8514 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6874 | 3.653 | 1.554 | 1.615 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.533 | 1.675 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 468.50368 | 1.017 | -0.9688 | -0.9537 | -0.9463 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9296 | -0.5755 | -0.6144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8797 | 0.4047 | -0.6643 | -0.5158 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1808 | -0.4408 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.50368 | 101.7 | -4.069 | -0.9536 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01109 | 0.8511 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6949 | 3.630 | 1.560 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.529 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.50368</span> | 101.7 | 0.01710 | 0.2782 | 0.09265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8511 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6949 | 3.630 | 1.560 | 1.592 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.529 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 468.41664 | 1.014 | -0.9744 | -0.9593 | -0.9474 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9295 | -0.5802 | -0.6187 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8761 | 0.3987 | -0.6631 | -0.5237 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1828 | -0.4402 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.41664 | 101.4 | -4.074 | -0.9588 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8494 | 0.07709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6973 | 3.620 | 1.561 | 1.583 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.526 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.41664</span> | 101.4 | 0.01700 | 0.2771 | 0.09254 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8494 | 0.07709 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6973 | 3.620 | 1.561 | 1.583 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.526 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.72 | -0.02243 | -0.2559 | -0.2642 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4515 | 0.003975 | -3.178 | -2.839 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02889 | -0.8526 | -0.3239 | -1.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6251 | -0.1666 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 468.39161 | 1.011 | -0.9744 | -0.9571 | -0.9468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9295 | -0.5795 | -0.6181 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8777 | 0.4014 | -0.6637 | -0.5208 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1824 | -0.4404 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.39161 | 101.1 | -4.074 | -0.9567 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8496 | 0.07711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6962 | 3.624 | 1.561 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.527 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.39161</span> | 101.1 | 0.01700 | 0.2775 | 0.09260 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8496 | 0.07711 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6962 | 3.624 | 1.561 | 1.586 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.527 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3129 | -1.347 | -0.3359 | -0.08922 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3284 | 0.005471 | -2.643 | -3.028 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08821 | -0.8778 | -0.3083 | -0.9349 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6501 | -0.1781 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 468.37315 | 1.012 | -0.9728 | -0.9567 | -0.9467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9295 | -0.5763 | -0.6144 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8776 | 0.4024 | -0.6633 | -0.5197 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1816 | -0.4402 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.37315 | 101.2 | -4.073 | -0.9564 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8508 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6963 | 3.626 | 1.561 | 1.588 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.528 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.37315</span> | 101.2 | 0.01703 | 0.2776 | 0.09261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8508 | 0.07724 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6963 | 3.626 | 1.561 | 1.588 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.528 | 1.679 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.643 | -0.05906 | -0.3284 | -0.08464 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2659 | 0.005628 | -2.441 | -2.741 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1033 | -0.8597 | -0.2783 | -0.9091 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6423 | -0.1835 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 468.35774 | 1.011 | -0.9727 | -0.9524 | -0.9471 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9297 | -0.5762 | -0.6128 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8791 | 0.4096 | -0.6644 | -0.5136 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1797 | -0.4410 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.35774 | 101.1 | -4.073 | -0.9523 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8508 | 0.07729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6953 | 3.637 | 1.560 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.531 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.35774</span> | 101.1 | 0.01703 | 0.2784 | 0.09257 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8508 | 0.07729 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6953 | 3.637 | 1.560 | 1.595 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.531 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.235 | -0.7549 | -0.2072 | -0.03117 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2512 | 0.006470 | -2.488 | -2.805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1485 | -0.7903 | -0.1532 | -0.6368 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5813 | -0.1871 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 468.34230 | 1.012 | -0.9728 | -0.9537 | -0.9473 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9300 | -0.5748 | -0.6111 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8817 | 0.4177 | -0.6661 | -0.5086 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1765 | -0.4413 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.3423 | 101.2 | -4.073 | -0.9535 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8513 | 0.07735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6935 | 3.650 | 1.558 | 1.600 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.535 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.3423</span> | 101.2 | 0.01703 | 0.2782 | 0.09256 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8513 | 0.07735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6935 | 3.650 | 1.558 | 1.600 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.535 | 1.678 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.528 | 0.1613 | -0.1518 | -0.1427 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4211 | 0.005662 | -2.339 | -2.549 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1833 | -0.8387 | -0.3838 | -0.5791 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5586 | -0.2081 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 468.32828 | 1.011 | -0.9730 | -0.9582 | -0.9446 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9303 | -0.5739 | -0.6081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8827 | 0.4247 | -0.6653 | -0.5110 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1721 | -0.4394 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.32828 | 101.1 | -4.073 | -0.9578 | -2.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01110 | 0.8517 | 0.07745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6929 | 3.661 | 1.559 | 1.598 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.542 | 1.680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.32828</span> | 101.1 | 0.01703 | 0.2773 | 0.09281 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8517 | 0.07745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6929 | 3.661 | 1.559 | 1.598 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.542 | 1.680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.625 | -0.2716 | -0.4478 | 0.07059 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3746 | 0.006164 | -2.097 | -1.611 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05708 | -0.8042 | -0.2658 | -0.6338 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5023 | -0.1867 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 468.31633 | 1.012 | -0.9727 | -0.9524 | -0.9447 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9305 | -0.5707 | -0.6067 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8839 | 0.4327 | -0.6650 | -0.5105 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1703 | -0.4382 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.31633 | 101.2 | -4.073 | -0.9523 | -2.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01110 | 0.8528 | 0.07749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6921 | 3.674 | 1.559 | 1.598 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.545 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.31633</span> | 101.2 | 0.01703 | 0.2784 | 0.09280 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8528 | 0.07749 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6921 | 3.674 | 1.559 | 1.598 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.545 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.853 | 0.6395 | -0.04718 | -0.01095 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5142 | 0.005281 | -1.984 | -1.469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06825 | -0.7616 | -0.1275 | -0.5767 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4529 | -0.1729 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 468.30195 | 1.011 | -0.9730 | -0.9497 | -0.9482 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9586 | -0.9308 | -0.5675 | -0.6075 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8868 | 0.4402 | -0.6670 | -0.5066 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1704 | -0.4381 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.30195 | 101.1 | -4.073 | -0.9498 | -2.381 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.059 | -0.01110 | 0.8540 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6901 | 3.686 | 1.556 | 1.603 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.544 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.30195</span> | 101.1 | 0.01703 | 0.2789 | 0.09247 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01727 | 0.4972 | 0.8540 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6901 | 3.686 | 1.556 | 1.603 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.544 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.407 | -0.4624 | -0.02880 | -0.1214 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5499 | 0.005628 | -1.325 | -1.518 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1161 | -0.7707 | -0.3300 | -0.4912 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4772 | -0.1931 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 468.29210 | 1.012 | -0.9733 | -0.9523 | -0.9459 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9311 | -0.5658 | -0.6073 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8878 | 0.4488 | -0.6682 | -0.5015 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1697 | -0.4385 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.2921 | 101.2 | -4.073 | -0.9523 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01111 | 0.8546 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6894 | 3.699 | 1.555 | 1.608 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.2921</span> | 101.2 | 0.01702 | 0.2784 | 0.09269 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8546 | 0.07747 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6894 | 3.699 | 1.555 | 1.608 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.681 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 468.28540 | 1.012 | -0.9739 | -0.9554 | -0.9432 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9314 | -0.5648 | -0.6081 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | 0.4579 | -0.6697 | -0.4962 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1692 | -0.4390 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.2854 | 101.2 | -4.074 | -0.9551 | -2.376 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01111 | 0.8550 | 0.07745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6886 | 3.714 | 1.553 | 1.615 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.2854</span> | 101.2 | 0.01701 | 0.2779 | 0.09293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8550 | 0.07745 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6886 | 3.714 | 1.553 | 1.615 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.644 | 0.03668 | -0.1986 | 0.05251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5265 | 0.006364 | -2.013 | -2.999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3077 | -0.7577 | -0.4283 | -0.2217 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4457 | -0.1968 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 468.26285 | 1.012 | -0.9738 | -0.9546 | -0.9455 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9321 | -0.5638 | -0.6053 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8894 | 0.4796 | -0.6701 | -0.4937 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1665 | -0.4375 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.26285 | 101.2 | -4.074 | -0.9544 | -2.378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01112 | 0.8554 | 0.07754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.748 | 1.552 | 1.617 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.550 | 1.682 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26285</span> | 101.2 | 0.01701 | 0.2780 | 0.09272 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8554 | 0.07754 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.748 | 1.552 | 1.617 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.550 | 1.682 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 468.24808 | 1.012 | -0.9737 | -0.9538 | -0.9478 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9328 | -0.5632 | -0.6032 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8900 | 0.5018 | -0.6707 | -0.4913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1639 | -0.4361 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.24808 | 101.2 | -4.074 | -0.9537 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8556 | 0.07761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6879 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24808</span> | 101.2 | 0.01701 | 0.2781 | 0.09251 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8556 | 0.07761 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6879 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.572 | 0.7442 | -0.1004 | -0.2485 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5511 | 0.005645 | -1.896 | -1.976 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3421 | -0.6164 | -0.3384 | -0.1002 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3637 | -0.1858 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 468.24925 | 1.009 | -0.9744 | -0.9459 | -0.9275 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9342 | -0.5606 | -0.6003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8814 | 0.5390 | -0.6664 | -0.4916 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1575 | -0.4319 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.24925 | 100.9 | -4.074 | -0.9463 | -2.360 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01114 | 0.8565 | 0.07771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6937 | 3.842 | 1.557 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.563 | 1.689 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24925</span> | 100.9 | 0.01700 | 0.2796 | 0.09441 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8565 | 0.07771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6937 | 3.842 | 1.557 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.563 | 1.689 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 468.25666 | 1.009 | -0.9742 | -0.9500 | -0.9379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9335 | -0.5615 | -0.6013 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8858 | 0.5198 | -0.6685 | -0.4914 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1608 | -0.4340 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.25666 | 100.9 | -4.074 | -0.9501 | -2.371 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8562 | 0.07768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6908 | 3.812 | 1.554 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.686 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.25666</span> | 100.9 | 0.01701 | 0.2789 | 0.09342 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07768 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6908 | 3.812 | 1.554 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.686 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 468.26483 | 1.009 | -0.9741 | -0.9524 | -0.9439 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9331 | -0.5620 | -0.6018 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8883 | 0.5089 | -0.6697 | -0.4913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1626 | -0.4352 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.26483 | 100.9 | -4.074 | -0.9523 | -2.377 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8560 | 0.07766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 3.794 | 1.553 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26483</span> | 100.9 | 0.01701 | 0.2784 | 0.09287 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8560 | 0.07766 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 3.794 | 1.553 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 468.25961 | 1.009 | -0.9740 | -0.9538 | -0.9477 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9328 | -0.5624 | -0.6023 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5020 | -0.6705 | -0.4913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4360 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.25961 | 100.9 | -4.074 | -0.9536 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8558 | 0.07764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.25961</span> | 100.9 | 0.01701 | 0.2782 | 0.09252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8558 | 0.07764 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 468.24351 | 1.011 | -0.9738 | -0.9538 | -0.9477 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9328 | -0.5629 | -0.6029 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8899 | 0.5019 | -0.6706 | -0.4913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1638 | -0.4360 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.24351 | 101.1 | -4.074 | -0.9537 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8557 | 0.07762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24351</span> | 101.1 | 0.01701 | 0.2781 | 0.09252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8557 | 0.07762 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7570 | -0.04882 | -0.1901 | -0.1704 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4436 | 0.006358 | -1.944 | -2.069 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3547 | -0.6277 | -0.2411 | -0.07768 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3909 | -0.1932 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 468.24096 | 1.012 | -0.9738 | -0.9538 | -0.9477 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9328 | -0.5622 | -0.6021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5021 | -0.6705 | -0.4913 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4360 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.24096 | 101.2 | -4.074 | -0.9536 | -2.380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8559 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.784 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24096</span> | 101.2 | 0.01701 | 0.2782 | 0.09252 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8559 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.784 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.456 | 0.1549 | -0.1619 | -0.1892 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4078 | 0.006267 | -1.860 | -2.735 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3543 | -0.6265 | -0.1851 | -0.08656 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3612 | -0.1856 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 468.23716 | 1.012 | -0.9738 | -0.9536 | -0.9467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9329 | -0.5614 | -0.6008 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5037 | -0.6704 | -0.4911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1638 | -0.4357 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23716 | 101.2 | -4.074 | -0.9534 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8562 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23716</span> | 101.2 | 0.01701 | 0.2782 | 0.09261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.250 | 0.2329 | -0.1405 | -0.1467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3393 | 0.006453 | -1.023 | -1.889 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3583 | -0.6239 | -0.2353 | -0.09107 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3636 | -0.1837 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 468.26529 | 1.008 | -0.9742 | -0.9534 | -0.9465 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9571 | -0.9329 | -0.5599 | -0.5980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | 0.5046 | -0.6700 | -0.4910 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1633 | -0.4354 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.26529 | 100.8 | -4.074 | -0.9532 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8568 | 0.07778 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.553 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26529</span> | 100.8 | 0.01701 | 0.2782 | 0.09263 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8568 | 0.07778 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.553 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 468.23604 | 1.011 | -0.9739 | -0.9535 | -0.9467 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9329 | -0.5612 | -0.6003 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8897 | 0.5039 | -0.6703 | -0.4911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4357 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23604 | 101.1 | -4.074 | -0.9534 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8563 | 0.07771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23604</span> | 101.1 | 0.01701 | 0.2782 | 0.09261 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8563 | 0.07771 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.188 | -0.1927 | -0.1868 | -0.1045 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2665 | 0.006857 | -1.024 | -1.172 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2153 | -0.6125 | -0.1502 | -0.07921 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3902 | -0.1918 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 468.23464 | 1.012 | -0.9738 | -0.9534 | -0.9465 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9329 | -0.5609 | -0.6000 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8895 | 0.5043 | -0.6702 | -0.4911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1635 | -0.4356 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23464 | 101.2 | -4.074 | -0.9533 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8564 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.787 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23464</span> | 101.2 | 0.01701 | 0.2782 | 0.09263 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8564 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.787 | 1.552 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.857 | 0.1925 | -0.1360 | -0.1332 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2859 | 0.006578 | -0.9819 | -1.076 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2136 | -0.6087 | -0.2154 | -0.09459 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3609 | -0.1836 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 468.23346 | 1.011 | -0.9739 | -0.9532 | -0.9463 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9329 | -0.5607 | -0.5998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | 0.5049 | -0.6701 | -0.4911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1633 | -0.4355 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23346 | 101.1 | -4.074 | -0.9531 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8565 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.552 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23346</span> | 101.1 | 0.01701 | 0.2783 | 0.09265 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8565 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.552 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.112 | -0.08635 | -0.1600 | -0.09176 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2402 | 0.006873 | -0.9941 | -1.084 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2133 | -0.6080 | -0.2006 | -0.08423 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3853 | -0.1906 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 468.23209 | 1.012 | -0.9738 | -0.9531 | -0.9461 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9329 | -0.5604 | -0.5995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8891 | 0.5054 | -0.6700 | -0.4910 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1631 | -0.4354 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23209 | 101.2 | -4.074 | -0.9530 | -2.379 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8566 | 0.07774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6885 | 3.789 | 1.553 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23209</span> | 101.2 | 0.01701 | 0.2783 | 0.09266 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8566 | 0.07774 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6885 | 3.789 | 1.553 | 1.621 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 468.23061 | 1.012 | -0.9738 | -0.9526 | -0.9453 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9330 | -0.5604 | -0.5995 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8885 | 0.5071 | -0.6698 | -0.4911 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1626 | -0.4353 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.23061 | 101.2 | -4.074 | -0.9525 | -2.378 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8566 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6889 | 3.791 | 1.553 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23061</span> | 101.2 | 0.01701 | 0.2784 | 0.09274 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8566 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6889 | 3.791 | 1.553 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 468.22552 | 1.012 | -0.9738 | -0.9506 | -0.9419 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9333 | -0.5606 | -0.5998 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8861 | 0.5138 | -0.6689 | -0.4912 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1606 | -0.4347 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.22552 | 101.2 | -4.074 | -0.9506 | -2.375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8565 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6906 | 3.802 | 1.554 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.22552</span> | 101.2 | 0.01701 | 0.2788 | 0.09305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8565 | 0.07773 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6906 | 3.802 | 1.554 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.685 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 468.21689 | 1.012 | -0.9737 | -0.9426 | -0.9286 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9344 | -0.5614 | -0.6009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8763 | 0.5405 | -0.6653 | -0.4919 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1525 | -0.4325 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.21689 | 101.2 | -4.074 | -0.9431 | -2.361 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01114 | 0.8562 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6972 | 3.844 | 1.558 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.571 | 1.688 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.21689</span> | 101.2 | 0.01701 | 0.2803 | 0.09430 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6972 | 3.844 | 1.558 | 1.620 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.571 | 1.688 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.525 | 0.5842 | 0.4183 | 0.9468 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | 0.008618 | -1.874 | -1.936 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2463 | -0.5498 | 0.04440 | -0.1490 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2038 | -0.1015 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 468.19158 | 1.011 | -0.9737 | -0.9504 | -0.9293 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9362 | -0.5600 | -0.6009 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8523 | 0.5756 | -0.6644 | -0.4878 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1417 | -0.4298 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.19158 | 101.1 | -4.074 | -0.9504 | -2.362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01116 | 0.8567 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7134 | 3.900 | 1.560 | 1.624 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.691 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.19158</span> | 101.1 | 0.01701 | 0.2788 | 0.09423 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8567 | 0.07769 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7134 | 3.900 | 1.560 | 1.624 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.691 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.990 | 0.8226 | -0.02734 | 0.9308 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6358 | 0.008756 | -3.089 | -2.706 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08468 | -0.5047 | 0.1760 | -0.08785 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.06839 | -0.06706 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 468.16872 | 1.012 | -0.9746 | -0.9536 | -0.9297 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9583 | -0.9383 | -0.5551 | -0.6021 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8428 | 0.6190 | -0.6652 | -0.4874 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1424 | -0.4276 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.16872 | 101.2 | -4.075 | -0.9534 | -2.362 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01118 | 0.8585 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7198 | 3.968 | 1.559 | 1.625 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.586 | 1.694 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.16872</span> | 101.2 | 0.01700 | 0.2782 | 0.09420 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8585 | 0.07765 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7198 | 3.968 | 1.559 | 1.625 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.586 | 1.694 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.949 | 1.224 | -0.09904 | 0.8335 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8902 | 0.008091 | -1.732 | -1.975 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02618 | -0.4349 | 0.2067 | -0.1419 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.09587 | -0.05531 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 468.14579 | 1.011 | -0.9759 | -0.9465 | -0.9356 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9407 | -0.5519 | -0.5999 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8420 | 0.6626 | -0.6664 | -0.4855 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1418 | -0.4273 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.14579 | 101.1 | -4.076 | -0.9467 | -2.368 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01121 | 0.8597 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.037 | 1.557 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.694 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.14579</span> | 101.1 | 0.01698 | 0.2795 | 0.09364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8597 | 0.07772 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.037 | 1.557 | 1.627 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.694 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -9.402 | -0.5832 | 0.1847 | 0.5188 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4155 | 0.008564 | -1.671 | -1.980 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03632 | -0.3649 | 0.3304 | -0.09551 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1039 | -0.08698 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 468.12514 | 1.011 | -0.9763 | -0.9445 | -0.9403 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9555 | -0.9442 | -0.5537 | -0.5953 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8391 | 0.7059 | -0.6668 | -0.4805 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1376 | -0.4223 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.12514 | 101.1 | -4.076 | -0.9449 | -2.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01125 | 0.8590 | 0.07788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7223 | 4.106 | 1.557 | 1.633 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.593 | 1.700 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.12514</span> | 101.1 | 0.01697 | 0.2799 | 0.09320 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8590 | 0.07788 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7223 | 4.106 | 1.557 | 1.633 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.593 | 1.700 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.823 | -0.4010 | 0.3316 | 0.1628 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2993 | 0.008766 | -1.373 | -1.049 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008284 | -0.3402 | 0.4029 | 0.04088 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03436 | -0.04680 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 468.10920 | 1.012 | -0.9773 | -0.9503 | -0.9395 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9556 | -0.9476 | -0.5516 | -0.5942 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8420 | 0.7499 | -0.6684 | -0.4836 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1347 | -0.4216 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.1092 | 101.2 | -4.077 | -0.9504 | -2.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01129 | 0.8598 | 0.07791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.175 | 1.555 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.597 | 1.700 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.1092</span> | 101.2 | 0.01695 | 0.2788 | 0.09328 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8598 | 0.07791 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.175 | 1.555 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.597 | 1.700 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.4262 | -0.09925 | 0.1213 | 0.1364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2200 | 0.008054 | -0.8480 | -0.9224 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.002683 | -0.2932 | 0.3866 | -0.06974 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01820 | -0.05063 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 468.09766 | 1.011 | -0.9774 | -0.9506 | -0.9392 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -0.9508 | -0.5497 | -0.5929 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8318 | 0.7901 | -0.6724 | -0.4776 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1474 | -0.4133 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.09766 | 101.1 | -4.077 | -0.9507 | -2.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01132 | 0.8605 | 0.07796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7273 | 4.239 | 1.550 | 1.636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.578 | 1.710 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.09766</span> | 101.1 | 0.01695 | 0.2788 | 0.09331 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8605 | 0.07796 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7273 | 4.239 | 1.550 | 1.636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.578 | 1.710 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.610 | 0.04645 | 0.08092 | 0.1870 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1143 | 0.008788 | -0.7906 | -0.9380 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03576 | -0.2567 | 0.2790 | 0.04583 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1853 | 0.03622 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 468.08577 | 1.011 | -0.9779 | -0.9521 | -0.9394 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9550 | -0.5484 | -0.5900 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8316 | 0.8332 | -0.6752 | -0.4781 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1428 | -0.4231 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.08577 | 101.1 | -4.078 | -0.9520 | -2.372 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01137 | 0.8610 | 0.07805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7274 | 4.307 | 1.546 | 1.635 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.585 | 1.699 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.08577</span> | 101.1 | 0.01694 | 0.2785 | 0.09329 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8610 | 0.07805 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7274 | 4.307 | 1.546 | 1.635 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.585 | 1.699 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.835 | -0.08271 | 0.01028 | 0.1502 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2859 | 0.008536 | -0.7298 | -0.7597 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09519 | -0.2281 | 0.1720 | -0.01715 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1386 | -0.1062 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 468.06947 | 1.011 | -0.9795 | -0.9573 | -0.9407 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9652 | -0.5443 | -0.5834 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8515 | 0.9153 | -0.6785 | -0.4834 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1291 | -0.4003 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.06947 | 101.1 | -4.080 | -0.9569 | -2.373 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01148 | 0.8625 | 0.07827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7139 | 4.437 | 1.542 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.605 | 1.725 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.06947</span> | 101.1 | 0.01692 | 0.2775 | 0.09316 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4971 | 0.8625 | 0.07827 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7139 | 4.437 | 1.542 | 1.629 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.605 | 1.725 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.887 | -0.6407 | -0.1939 | 0.08469 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4208 | 0.006503 | -1.301 | -1.072 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1255 | -0.1861 | 0.1431 | -0.06050 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01658 | 0.1111 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 468.05012 | 1.012 | -0.9812 | -0.9547 | -0.9420 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9873 | -0.5356 | -0.5736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8556 | 1.092 | -0.6884 | -0.4796 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1211 | -0.3873 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.05012 | 101.2 | -4.081 | -0.9544 | -2.375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01172 | 0.8656 | 0.07860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05012</span> | 101.2 | 0.01689 | 0.2780 | 0.09305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4971 | 0.8656 | 0.07860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.331 | -0.3124 | 0.04539 | -0.09325 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3359 | 0.005628 | -0.9294 | -0.4404 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1788 | -0.1003 | -0.1180 | -0.02636 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.09915 | 0.1820 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 468.05341 | 1.012 | -0.9836 | -0.9687 | -0.9317 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9507 | -1.013 | -0.5235 | -0.5660 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8472 | 1.268 | -0.6904 | -0.4754 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1200 | -0.3857 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.05341 | 101.2 | -4.084 | -0.9676 | -2.364 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.051 | -0.01201 | 0.8700 | 0.07886 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 4.995 | 1.527 | 1.639 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.619 | 1.742 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05341</span> | 101.2 | 0.01685 | 0.2754 | 0.09401 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01741 | 0.4970 | 0.8700 | 0.07886 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 4.995 | 1.527 | 1.639 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.619 | 1.742 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 468.05012 | 1.012 | -0.9812 | -0.9547 | -0.9420 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9873 | -0.5356 | -0.5736 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8556 | 1.092 | -0.6884 | -0.4796 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1211 | -0.3873 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | U| 468.05012 | 101.2 | -4.081 | -0.9544 | -2.375 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01172 | 0.8656 | 0.07860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05012</span> | 101.2 | 0.01689 | 0.2780 | 0.09305 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4971 | 0.8656 | 0.07860 |</span> +<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> +<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> +<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> +<span class="r-out co"><span class="r-pr">#></span> done</span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> +<span class="r-msg co"><span class="r-pr">#></span> done</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nlmixr_dfop_sfo_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_dfop_sfo_focei</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> df AIC</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem$nm 16 1105.3725</span> +<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei$nm 14 810.3271</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlmixr_dfop_sfo_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'object' in selecting a method for function 'summary': object 'f_nlmixr_dfop_sfo_sfo' not found</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/summary.saem.mmkin.html b/docs/reference/summary.saem.mmkin.html new file mode 100644 index 00000000..2fe81023 --- /dev/null +++ b/docs/reference/summary.saem.mmkin.html @@ -0,0 +1,230 @@ +<!DOCTYPE html> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "saem.mmkin" — summary.saem.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" 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property="og:title" content="Summary method for class " saem.mmkin summary.saem.mmkin><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters +for fixed effects (population), random effects (deviations from the +population mean) and residual error model, as well as the resulting +endpoints such as formation fractions and DT50 values. Optionally +(default is FALSE), the data are listed in full."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> +<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> +<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + + + <div class="container template-reference-topic"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <div class="container"> + <div class="navbar-header"> + <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> + <span class="sr-only">Toggle navigation</span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + </button> + <span class="navbar-brand"> + <a class="navbar-link" href="../index.html">mkin</a> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> + </span> + </div> + + <div id="navbar" class="navbar-collapse collapse"> + <ul class="nav navbar-nav"><li> + <a href="../reference/index.html">Functions and data</a> +</li> +<li class="dropdown"> + <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + Articles + + <span class="caret"></span> + </a> + <ul class="dropdown-menu" role="menu"><li> + <a href="../articles/mkin.html">Introduction to mkin</a> + </li> + <li> + <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + </li> + <li> + <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Summary method for class "saem.mmkin"</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.saem.mmkin.R" class="external-link"><code>R/summary.saem.mmkin.R</code></a></small> + <div class="hidden name"><code>summary.saem.mmkin.Rd</code></div> + </div> + + <div class="ref-description"> + <p>Lists model equations, initial parameter values, optimised parameters +for fixed effects (population), random effects (deviations from the +population mean) and residual error model, as well as the resulting +endpoints such as formation fractions and DT50 values. Optionally +(default is FALSE), the data are listed in full.</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for saem.mmkin</span> +<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, verbose <span class="op">=</span> <span class="cn">FALSE</span>, distimes <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span> + +<span class="co"># S3 method for summary.saem.mmkin</span> +<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>an object of class <a href="saem.html">saem.mmkin</a></p></dd> +<dt>data</dt> +<dd><p>logical, indicating whether the full data should be included in +the summary.</p></dd> +<dt>verbose</dt> +<dd><p>Should the summary be verbose?</p></dd> +<dt>distimes</dt> +<dd><p>logical, indicating whether DT50 and DT90 values should be +included.</p></dd> +<dt>...</dt> +<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> +<dt>x</dt> +<dd><p>an object of class summary.saem.mmkin</p></dd> +<dt>digits</dt> +<dd><p>Number of digits to use for printing</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>The summary function returns a list based on the <a href="https://rdrr.io/pkg/saemix/man/SaemixObject-class.html" class="external-link">saemix::SaemixObject</a>obtained in the fit, with at least the following additional components</p> +<dl><dt>saemixversion, mkinversion, Rversion</dt> +<dd><p>The saemix, mkin and R versions used</p></dd> +<dt>date.fit, date.summary</dt> +<dd><p>The dates where the fit and the summary were +produced</p></dd> +<dt>diffs</dt> +<dd><p>The differential equations used in the degradation model</p></dd> +<dt>use_of_ff</dt> +<dd><p>Was maximum or minimum use made of formation fractions</p></dd> +<dt>data</dt> +<dd><p>The data</p></dd> +<dt>confint_trans</dt> +<dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> +<dt>confint_back</dt> +<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> +<dt>confint_errmod</dt> +<dd><p>Error model parameters with confidence intervals</p></dd> +<dt>ff</dt> +<dd><p>The estimated formation fractions derived from the fitted +model.</p></dd> +<dt>distimes</dt> +<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> +<dt>SFORB</dt> +<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> +</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> + </div> + <div id="author"> + <h2>Author</h2> + <p>Johannes Ranke for the mkin specific parts +saemix authors for the parts inherited from saemix.</p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># Generate five datasets following DFOP-SFO kinetics</span></span> +<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.1</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k2_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"><span class="va">g_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_parent_to_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"><span class="va">k_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">pred_dfop_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">f_parent_to_m1</span>, <span class="va">k_m1</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1</span>, k2 <span class="op">=</span> <span class="va">k2</span>, g <span class="op">=</span> <span class="va">g</span>, f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1</span>, k_m1 <span class="op">=</span> <span class="va">k_m1</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_mean_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k2 <span class="op">=</span> <span class="va">k2_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, g <span class="op">=</span> <span class="va">g_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>,</span> +<span class="r-in"> f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k_m1 <span class="op">=</span> <span class="va">k_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">ds_syn_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span> +<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span> +<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> +<span class="r-in"><span class="op">}</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="co"># Evaluate using mmkin and saem</span></span> +<span class="r-in"><span class="va">f_mmkin_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds_syn_dfop_sfo</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span> +<span class="r-in"><span class="va">f_saem_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> </span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in rxModelVars_(obj):</span> Not compatible with STRSXP: [type=NULL].</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'object' in selecting a method for function 'summary': object 'f_saem_dfop_sfo' not found</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/synthetic_data_for_UBA_2014-1.png b/docs/reference/synthetic_data_for_UBA_2014-1.png Binary files differindex 89975db5..132380a8 100644 --- a/docs/reference/synthetic_data_for_UBA_2014-1.png +++ b/docs/reference/synthetic_data_for_UBA_2014-1.png diff --git a/docs/reference/synthetic_data_for_UBA_2014.html b/docs/reference/synthetic_data_for_UBA_2014.html index c37b986e..7d79341c 100644 --- a/docs/reference/synthetic_data_for_UBA_2014.html +++ b/docs/reference/synthetic_data_for_UBA_2014.html @@ -1,46 +1,5 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014 • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- 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hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014"><meta property="og:description" content="The 12 datasets were generated using four different models and three different variance components. The four models are either the SFO or the DFOP model with either two sequential or two parallel metabolites. Variance component 'a' is based on a normal distribution with standard deviation of 3, @@ -55,28 +14,14 @@ Initial concentrations for metabolites and all values where adding the variance in a value below the assumed limit of detection of 0.1 were set to NA. As an example, the first dataset has the title SFO_lin_a and is based on the SFO model with two sequential metabolites (linear pathway), with added variance component 'a'. -Compare also the code in the example section to see the degradation models." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +Compare also the code in the example section to see the degradation models."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -87,13 +32,12 @@ Compare also the code in the example section to see the degradation models." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -102,8 +46,7 @@ Compare also the code in the example section to see the degradation models." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -113,6 +56,9 @@ Compare also the code in the example section to see the degradation models." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -127,30 +73,23 @@ Compare also the code in the example section to see the degradation models." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Synthetic datasets for one parent compound with two metabolites</h1> @@ -177,300 +116,308 @@ Compare also the code in the example section to see the degradation models." /> <p>Compare also the code in the example section to see the degradation models.</p> </div> - <pre class="usage"><span class='va'>synthetic_data_for_UBA_2014</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">synthetic_data_for_UBA_2014</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>A list containing twelve datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>, + each containing, among others, the following components</p><dl><dt><code>title</code></dt> +<dd><p>The name of the dataset, e.g. <code>SFO_lin_a</code></p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>data</code></dt> +<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - <p>A list containing twelve datasets as an R6 class defined by <code><a href='mkinds.html'>mkinds</a></code>, - each containing, among others, the following components</p><dl> - <dt><code>title</code></dt><dd><p>The name of the dataset, e.g. <code>SFO_lin_a</code></p></dd> - <dt><code>data</code></dt><dd><p>A data frame with the data in the form expected by <code><a href='mkinfit.html'>mkinfit</a></code></p></dd> -</dl> - - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> - +</dl></div> + <div id="source"> + <h2>Source</h2> <p>Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452</p> <p>Rocke, David M. und Lorenzato, Stefan (1995) A two-component model for measurement error in analytical chemistry. Technometrics 37(2), 176-184.</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> -<span class='co'># The data have been generated using the following kinetic models</span> -<span class='va'>m_synth_SFO_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"M2"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> - -<span class='va'>m_synth_SFO_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span>, - sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>m_synth_DFOP_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='st'>"M1"</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"M2"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>m_synth_DFOP_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"DFOP"</span>, to <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span>, - sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='co'># The model predictions without intentional error were generated as follows</span> -<span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> - -<span class='va'>d_synth_SFO_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_synth_SFO_lin</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.7</span>, f_parent_to_M1 <span class='op'>=</span> <span class='fl'>0.8</span>, - k_M1 <span class='op'>=</span> <span class='fl'>0.3</span>, f_M1_to_M2 <span class='op'>=</span> <span class='fl'>0.7</span>, - k_M2 <span class='op'>=</span> <span class='fl'>0.02</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, M1 <span class='op'>=</span> <span class='fl'>0</span>, M2 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - -<span class='va'>d_synth_DFOP_lin</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_synth_DFOP_lin</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k1 <span class='op'>=</span> <span class='fl'>0.2</span>, k2 <span class='op'>=</span> <span class='fl'>0.02</span>, g <span class='op'>=</span> <span class='fl'>0.5</span>, - f_parent_to_M1 <span class='op'>=</span> <span class='fl'>0.5</span>, k_M1 <span class='op'>=</span> <span class='fl'>0.3</span>, - f_M1_to_M2 <span class='op'>=</span> <span class='fl'>0.7</span>, k_M2 <span class='op'>=</span> <span class='fl'>0.02</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, M1 <span class='op'>=</span> <span class='fl'>0</span>, M2 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - -<span class='va'>d_synth_SFO_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_synth_SFO_par</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='fl'>0.2</span>, - f_parent_to_M1 <span class='op'>=</span> <span class='fl'>0.8</span>, k_M1 <span class='op'>=</span> <span class='fl'>0.01</span>, - f_parent_to_M2 <span class='op'>=</span> <span class='fl'>0.2</span>, k_M2 <span class='op'>=</span> <span class='fl'>0.02</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, M1 <span class='op'>=</span> <span class='fl'>0</span>, M2 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - -<span class='va'>d_synth_DFOP_par</span> <span class='op'><-</span> <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>m_synth_DFOP_par</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k1 <span class='op'>=</span> <span class='fl'>0.3</span>, k2 <span class='op'>=</span> <span class='fl'>0.02</span>, g <span class='op'>=</span> <span class='fl'>0.7</span>, - f_parent_to_M1 <span class='op'>=</span> <span class='fl'>0.6</span>, k_M1 <span class='op'>=</span> <span class='fl'>0.04</span>, - f_parent_to_M2 <span class='op'>=</span> <span class='fl'>0.4</span>, k_M2 <span class='op'>=</span> <span class='fl'>0.01</span><span class='op'>)</span>, - <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span>, M1 <span class='op'>=</span> <span class='fl'>0</span>, M2 <span class='op'>=</span> <span class='fl'>0</span><span class='op'>)</span>, - <span class='va'>sampling_times</span><span class='op'>)</span> - -<span class='co'># Construct names for datasets with errors</span> -<span class='va'>d_synth_names</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='st'>"d_synth_"</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"SFO_lin"</span>, <span class='st'>"SFO_par"</span>, - <span class='st'>"DFOP_lin"</span>, <span class='st'>"DFOP_par"</span><span class='op'>)</span><span class='op'>)</span> - -<span class='co'># Original function used or adding errors. The add_err function now published</span> -<span class='co'># with this package is a slightly generalised version where the names of</span> -<span class='co'># secondary compartments that should have an initial value of zero (M1 and M2</span> -<span class='co'># in this case) are not hardcoded any more.</span> -<span class='co'># add_err = function(d, sdfunc, LOD = 0.1, reps = 2, seed = 123456789)</span> -<span class='co'># {</span> -<span class='co'># set.seed(seed)</span> -<span class='co'># d_long = mkin_wide_to_long(d, time = "time")</span> -<span class='co'># d_rep = data.frame(lapply(d_long, rep, each = 2))</span> -<span class='co'># d_rep$value = rnorm(length(d_rep$value), d_rep$value, sdfunc(d_rep$value))</span> -<span class='co'>#</span> -<span class='co'># d_rep[d_rep$time == 0 & d_rep$name %in% c("M1", "M2"), "value"] <- 0</span> -<span class='co'># d_NA <- transform(d_rep, value = ifelse(value < LOD, NA, value))</span> -<span class='co'># d_NA$value <- round(d_NA$value, 1)</span> -<span class='co'># return(d_NA)</span> -<span class='co'># }</span> - -<span class='co'># The following is the simplified version of the two-component model of Rocke</span> -<span class='co'># and Lorenzato (1995)</span> -<span class='va'>sdfunc_twocomp</span> <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span>, <span class='va'>sd_low</span>, <span class='va'>rsd_high</span><span class='op'>)</span> <span class='op'>{</span> - <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>sqrt</a></span><span class='op'>(</span><span class='va'>sd_low</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>+</span> <span class='va'>value</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>*</span> <span class='va'>rsd_high</span><span class='op'>^</span><span class='fl'>2</span><span class='op'>)</span> -<span class='op'>}</span> - -<span class='co'># Add the errors.</span> -<span class='kw'>for</span> <span class='op'>(</span><span class='va'>d_synth_name</span> <span class='kw'>in</span> <span class='va'>d_synth_names</span><span class='op'>)</span> -<span class='op'>{</span> - <span class='va'>d_synth</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/get.html'>get</a></span><span class='op'>(</span><span class='va'>d_synth_name</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/assign.html'>assign</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='va'>d_synth_name</span>, <span class='st'>"_a"</span><span class='op'>)</span>, <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_synth</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fl'>3</span><span class='op'>)</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/assign.html'>assign</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='va'>d_synth_name</span>, <span class='st'>"_b"</span><span class='op'>)</span>, <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_synth</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fl'>7</span><span class='op'>)</span><span class='op'>)</span> - <span class='fu'><a href='https://rdrr.io/r/base/assign.html'>assign</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste0</a></span><span class='op'>(</span><span class='va'>d_synth_name</span>, <span class='st'>"_c"</span><span class='op'>)</span>, <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>d_synth</span>, - <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fu'>sdfunc_twocomp</span><span class='op'>(</span><span class='va'>value</span>, <span class='fl'>0.5</span>, <span class='fl'>0.07</span><span class='op'>)</span><span class='op'>)</span><span class='op'>)</span> - -<span class='op'>}</span> - -<span class='va'>d_synth_err_names</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span> - <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='fu'><a href='https://rdrr.io/r/base/rep.html'>rep</a></span><span class='op'>(</span><span class='va'>d_synth_names</span>, each <span class='op'>=</span> <span class='fl'>3</span><span class='op'>)</span>, <span class='va'>letters</span><span class='op'>[</span><span class='fl'>1</span><span class='op'>:</span><span class='fl'>3</span><span class='op'>]</span>, sep <span class='op'>=</span> <span class='st'>"_"</span><span class='op'>)</span> -<span class='op'>)</span> - -<span class='co'># This is just one example of an evaluation using the kinetic model used for</span> -<span class='co'># the generation of the data</span> - <span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_synth_SFO_lin</span>, <span class='va'>synthetic_data_for_UBA_2014</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, - quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> - <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='synthetic_data_for_UBA_2014-1.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> mkin version used for fitting: 1.0.3 -#> R version used for fitting: 4.0.3 -#> Date of fit: Mon Feb 15 13:46:15 2021 -#> Date of summary: Mon Feb 15 13:46:15 2021 -#> -#> Equations: -#> d_parent/dt = - k_parent * parent -#> d_M1/dt = + f_parent_to_M1 * k_parent * parent - k_M1 * M1 -#> d_M2/dt = + f_M1_to_M2 * k_M1 * M1 - k_M2 * M2 -#> -#> Model predictions using solution type deSolve -#> -#> Fitted using 833 model solutions performed in 0.665 s -#> -#> Error model: Constant variance -#> -#> Error model algorithm: OLS -#> -#> Starting values for parameters to be optimised: -#> value type -#> parent_0 101.3500 state -#> k_parent 0.1000 deparm -#> k_M1 0.1001 deparm -#> k_M2 0.1002 deparm -#> f_parent_to_M1 0.5000 deparm -#> f_M1_to_M2 0.5000 deparm -#> -#> Starting values for the transformed parameters actually optimised: -#> value lower upper -#> parent_0 101.350000 -Inf Inf -#> log_k_parent -2.302585 -Inf Inf -#> log_k_M1 -2.301586 -Inf Inf -#> log_k_M2 -2.300587 -Inf Inf -#> f_parent_qlogis 0.000000 -Inf Inf -#> f_M1_qlogis 0.000000 -Inf Inf -#> -#> Fixed parameter values: -#> value type -#> M1_0 0 state -#> M2_0 0 state -#> -#> Results: -#> -#> AIC BIC logLik -#> 188.7274 200.3723 -87.36368 -#> -#> Optimised, transformed parameters with symmetric confidence intervals: -#> Estimate Std. Error Lower Upper -#> parent_0 102.1000 1.57000 98.8600 105.3000 -#> log_k_parent -0.3020 0.03885 -0.3812 -0.2229 -#> log_k_M1 -1.2070 0.07123 -1.3520 -1.0620 -#> log_k_M2 -3.9010 0.06571 -4.0350 -3.7670 -#> f_parent_qlogis 1.2010 0.23530 0.7216 1.6800 -#> f_M1_qlogis 0.9589 0.24890 0.4520 1.4660 -#> sigma 2.2730 0.25740 1.7490 2.7970 -#> -#> Parameter correlation: -#> parent_0 log_k_parent log_k_M1 log_k_M2 f_parent_qlogis -#> parent_0 1.000e+00 3.933e-01 -1.605e-01 2.819e-02 -4.624e-01 -#> log_k_parent 3.933e-01 1.000e+00 -4.082e-01 7.166e-02 -5.682e-01 -#> log_k_M1 -1.605e-01 -4.082e-01 1.000e+00 -3.929e-01 7.478e-01 -#> log_k_M2 2.819e-02 7.166e-02 -3.929e-01 1.000e+00 -2.658e-01 -#> f_parent_qlogis -4.624e-01 -5.682e-01 7.478e-01 -2.658e-01 1.000e+00 -#> f_M1_qlogis 1.614e-01 4.102e-01 -8.109e-01 5.419e-01 -8.605e-01 -#> sigma -2.900e-08 -8.030e-09 -2.741e-08 3.938e-08 -2.681e-08 -#> f_M1_qlogis sigma -#> parent_0 1.614e-01 -2.900e-08 -#> log_k_parent 4.102e-01 -8.030e-09 -#> log_k_M1 -8.109e-01 -2.741e-08 -#> log_k_M2 5.419e-01 3.938e-08 -#> f_parent_qlogis -8.605e-01 -2.681e-08 -#> f_M1_qlogis 1.000e+00 4.971e-08 -#> sigma 4.971e-08 1.000e+00 -#> -#> Backtransformed parameters: -#> Confidence intervals for internally transformed parameters are asymmetric. -#> t-test (unrealistically) based on the assumption of normal distribution -#> for estimators of untransformed parameters. -#> Estimate t value Pr(>t) Lower Upper -#> parent_0 102.10000 65.000 7.281e-36 98.86000 105.30000 -#> k_parent 0.73930 25.740 2.948e-23 0.68310 0.80020 -#> k_M1 0.29920 14.040 1.577e-15 0.25880 0.34590 -#> k_M2 0.02023 15.220 1.653e-16 0.01769 0.02312 -#> f_parent_to_M1 0.76870 18.370 7.295e-19 0.67300 0.84290 -#> f_M1_to_M2 0.72290 14.500 6.418e-16 0.61110 0.81240 -#> sigma 2.27300 8.832 2.161e-10 1.74900 2.79700 -#> -#> FOCUS Chi2 error levels in percent: -#> err.min n.optim df -#> All data 8.454 6 17 -#> parent 8.660 2 6 -#> M1 10.583 2 5 -#> M2 3.586 2 6 -#> -#> Resulting formation fractions: -#> ff -#> parent_M1 0.7687 -#> parent_sink 0.2313 -#> M1_M2 0.7229 -#> M1_sink 0.2771 -#> -#> Estimated disappearance times: -#> DT50 DT90 -#> parent 0.9376 3.114 -#> M1 2.3170 7.697 -#> M2 34.2689 113.839 -#> -#> Data: -#> time variable observed predicted residual -#> 0 parent 101.5 1.021e+02 -0.56248 -#> 0 parent 101.2 1.021e+02 -0.86248 -#> 1 parent 53.9 4.873e+01 5.17118 -#> 1 parent 47.5 4.873e+01 -1.22882 -#> 3 parent 10.4 1.111e+01 -0.70773 -#> 3 parent 7.6 1.111e+01 -3.50773 -#> 7 parent 1.1 5.772e-01 0.52283 -#> 7 parent 0.3 5.772e-01 -0.27717 -#> 14 parent 3.5 3.264e-03 3.49674 -#> 28 parent 3.2 1.045e-07 3.20000 -#> 90 parent 0.6 9.530e-10 0.60000 -#> 120 parent 3.5 -5.940e-10 3.50000 -#> 1 M1 36.4 3.479e+01 1.61088 -#> 1 M1 37.4 3.479e+01 2.61088 -#> 3 M1 34.3 3.937e+01 -5.07027 -#> 3 M1 39.8 3.937e+01 0.42973 -#> 7 M1 15.1 1.549e+01 -0.38715 -#> 7 M1 17.8 1.549e+01 2.31285 -#> 14 M1 5.8 1.995e+00 3.80469 -#> 14 M1 1.2 1.995e+00 -0.79531 -#> 60 M1 0.5 2.111e-06 0.50000 -#> 90 M1 3.2 -9.670e-10 3.20000 -#> 120 M1 1.5 7.670e-10 1.50000 -#> 120 M1 0.6 7.670e-10 0.60000 -#> 1 M2 4.8 4.455e+00 0.34517 -#> 3 M2 20.9 2.153e+01 -0.62527 -#> 3 M2 19.3 2.153e+01 -2.22527 -#> 7 M2 42.0 4.192e+01 0.07941 -#> 7 M2 43.1 4.192e+01 1.17941 -#> 14 M2 49.4 4.557e+01 3.83353 -#> 14 M2 44.3 4.557e+01 -1.26647 -#> 28 M2 34.6 3.547e+01 -0.87275 -#> 28 M2 33.0 3.547e+01 -2.47275 -#> 60 M2 18.8 1.858e+01 0.21837 -#> 60 M2 17.6 1.858e+01 -0.98163 -#> 90 M2 10.6 1.013e+01 0.47130 -#> 90 M2 10.8 1.013e+01 0.67130 -#> 120 M2 9.8 5.521e+00 4.27893 -#> 120 M2 3.3 5.521e+00 -2.22107</div><div class='input'><span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="co"># The data have been generated using the following kinetic models</span></span> +<span class="r-in"><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">m_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">m_synth_DFOP_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> +<span class="r-in"> sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The model predictions without intentional error were generated as follows</span></span> +<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.7</span>, f_parent_to_M1 <span class="op">=</span> <span class="fl">0.8</span>,</span> +<span class="r-in"> k_M1 <span class="op">=</span> <span class="fl">0.3</span>, f_M1_to_M2 <span class="op">=</span> <span class="fl">0.7</span>,</span> +<span class="r-in"> k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d_synth_DFOP_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_DFOP_lin</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="fl">0.2</span>, k2 <span class="op">=</span> <span class="fl">0.02</span>, g <span class="op">=</span> <span class="fl">0.5</span>,</span> +<span class="r-in"> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>, k_M1 <span class="op">=</span> <span class="fl">0.3</span>,</span> +<span class="r-in"> f_M1_to_M2 <span class="op">=</span> <span class="fl">0.7</span>, k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_SFO_par</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.2</span>,</span> +<span class="r-in"> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.8</span>, k_M1 <span class="op">=</span> <span class="fl">0.01</span>,</span> +<span class="r-in"> f_parent_to_M2 <span class="op">=</span> <span class="fl">0.2</span>, k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="fl">0.3</span>, k2 <span class="op">=</span> <span class="fl">0.02</span>, g <span class="op">=</span> <span class="fl">0.7</span>,</span> +<span class="r-in"> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.6</span>, k_M1 <span class="op">=</span> <span class="fl">0.04</span>,</span> +<span class="r-in"> f_parent_to_M2 <span class="op">=</span> <span class="fl">0.4</span>, k_M2 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> +<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Construct names for datasets with errors</span></span> +<span class="r-in"><span class="va">d_synth_names</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"d_synth_"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO_lin"</span>, <span class="st">"SFO_par"</span>,</span> +<span class="r-in"> <span class="st">"DFOP_lin"</span>, <span class="st">"DFOP_par"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Original function used or adding errors. The add_err function now published</span></span> +<span class="r-in"><span class="co"># with this package is a slightly generalised version where the names of</span></span> +<span class="r-in"><span class="co"># secondary compartments that should have an initial value of zero (M1 and M2</span></span> +<span class="r-in"><span class="co"># in this case) are not hardcoded any more.</span></span> +<span class="r-in"><span class="co"># add_err = function(d, sdfunc, LOD = 0.1, reps = 2, seed = 123456789)</span></span> +<span class="r-in"><span class="co"># {</span></span> +<span class="r-in"><span class="co"># set.seed(seed)</span></span> +<span class="r-in"><span class="co"># d_long = mkin_wide_to_long(d, time = "time")</span></span> +<span class="r-in"><span class="co"># d_rep = data.frame(lapply(d_long, rep, each = 2))</span></span> +<span class="r-in"><span class="co"># d_rep$value = rnorm(length(d_rep$value), d_rep$value, sdfunc(d_rep$value))</span></span> +<span class="r-in"><span class="co">#</span></span> +<span class="r-in"><span class="co"># d_rep[d_rep$time == 0 & d_rep$name %in% c("M1", "M2"), "value"] <- 0</span></span> +<span class="r-in"><span class="co"># d_NA <- transform(d_rep, value = ifelse(value < LOD, NA, value))</span></span> +<span class="r-in"><span class="co"># d_NA$value <- round(d_NA$value, 1)</span></span> +<span class="r-in"><span class="co"># return(d_NA)</span></span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># The following is the simplified version of the two-component model of Rocke</span></span> +<span class="r-in"><span class="co"># and Lorenzato (1995)</span></span> +<span class="r-in"><span class="va">sdfunc_twocomp</span> <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span>, <span class="va">sd_low</span>, <span class="va">rsd_high</span><span class="op">)</span> <span class="op">{</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="va">sd_low</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="va">rsd_high</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Add the errors.</span></span> +<span class="r-in"><span class="kw">for</span> <span class="op">(</span><span class="va">d_synth_name</span> <span class="kw">in</span> <span class="va">d_synth_names</span><span class="op">)</span></span> +<span class="r-in"><span class="op">{</span></span> +<span class="r-in"> <span class="va">d_synth</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/get.html" class="external-link">get</a></span><span class="op">(</span><span class="va">d_synth_name</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_a"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">3</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_b"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">7</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_c"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>,</span> +<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu">sdfunc_twocomp</span><span class="op">(</span><span class="va">value</span>, <span class="fl">0.5</span>, <span class="fl">0.07</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="op">}</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">d_synth_err_names</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="va">d_synth_names</span>, each <span class="op">=</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">letters</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, sep <span class="op">=</span> <span class="st">"_"</span><span class="op">)</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># This is just one example of an evaluation using the kinetic model used for</span></span> +<span class="r-in"><span class="co"># the generation of the data</span></span> +<span class="r-in"> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>, <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>,</span> +<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="synthetic_data_for_UBA_2014-1.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.1.0 </span> +<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of fit: Wed Mar 2 13:44:06 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> Date of summary: Wed Mar 2 13:44:06 2022 </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Equations:</span> +<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> +<span class="r-out co"><span class="r-pr">#></span> d_M1/dt = + f_parent_to_M1 * k_parent * parent - k_M1 * M1</span> +<span class="r-out co"><span class="r-pr">#></span> d_M2/dt = + f_M1_to_M2 * k_M1 * M1 - k_M2 * M2</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type deSolve </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fitted using 833 model solutions performed in 0.756 s</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 101.3500 state</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.1000 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> k_M1 0.1001 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> k_M2 0.1002 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.5000 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M2 0.5000 deparm</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> +<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 101.350000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.302585 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -2.301586 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M2 -2.300587 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 0.000000 -Inf Inf</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> +<span class="r-out co"><span class="r-pr">#></span> value type</span> +<span class="r-out co"><span class="r-pr">#></span> M1_0 0 state</span> +<span class="r-out co"><span class="r-pr">#></span> M2_0 0 state</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Results:</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> +<span class="r-out co"><span class="r-pr">#></span> 188.7274 200.3723 -87.36368</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 102.1000 1.57000 98.8600 105.3000</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -0.3020 0.03885 -0.3812 -0.2229</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -1.2070 0.07123 -1.3520 -1.0620</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M2 -3.9010 0.06571 -4.0350 -3.7670</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 1.2010 0.23530 0.7216 1.6800</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 0.9589 0.24890 0.4520 1.4660</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.2730 0.25740 1.7490 2.7970</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent log_k_M1 log_k_M2 f_parent_qlogis</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 3.933e-01 -1.605e-01 2.819e-02 -4.624e-01</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent 3.933e-01 1.000e+00 -4.082e-01 7.166e-02 -5.682e-01</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -1.605e-01 -4.082e-01 1.000e+00 -3.929e-01 7.478e-01</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M2 2.819e-02 7.166e-02 -3.929e-01 1.000e+00 -2.658e-01</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -4.624e-01 -5.682e-01 7.478e-01 -2.658e-01 1.000e+00</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 1.614e-01 4.102e-01 -8.109e-01 5.419e-01 -8.605e-01</span> +<span class="r-out co"><span class="r-pr">#></span> sigma -2.900e-08 -8.030e-09 -2.741e-08 3.938e-08 -2.681e-08</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis sigma</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 1.614e-01 -2.900e-08</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent 4.102e-01 -8.030e-09</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -8.109e-01 -2.741e-08</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_M2 5.419e-01 3.938e-08</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -8.605e-01 -2.681e-08</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 1.000e+00 4.971e-08</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 4.971e-08 1.000e+00</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> +<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> +<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> +<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> +<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 102.10000 65.000 7.281e-36 98.86000 105.30000</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.73930 25.740 2.948e-23 0.68310 0.80020</span> +<span class="r-out co"><span class="r-pr">#></span> k_M1 0.29920 14.040 1.577e-15 0.25880 0.34590</span> +<span class="r-out co"><span class="r-pr">#></span> k_M2 0.02023 15.220 1.653e-16 0.01769 0.02312</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.76870 18.370 7.295e-19 0.67300 0.84290</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M2 0.72290 14.500 6.418e-16 0.61110 0.81240</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 2.27300 8.832 2.161e-10 1.74900 2.79700</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 8.454 6 17</span> +<span class="r-out co"><span class="r-pr">#></span> parent 8.660 2 6</span> +<span class="r-out co"><span class="r-pr">#></span> M1 10.583 2 5</span> +<span class="r-out co"><span class="r-pr">#></span> M2 3.586 2 6</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> +<span class="r-out co"><span class="r-pr">#></span> ff</span> +<span class="r-out co"><span class="r-pr">#></span> parent_M1 0.7687</span> +<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.2313</span> +<span class="r-out co"><span class="r-pr">#></span> M1_M2 0.7229</span> +<span class="r-out co"><span class="r-pr">#></span> M1_sink 0.2771</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> +<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> +<span class="r-out co"><span class="r-pr">#></span> parent 0.9376 3.114</span> +<span class="r-out co"><span class="r-pr">#></span> M1 2.3170 7.697</span> +<span class="r-out co"><span class="r-pr">#></span> M2 34.2689 113.839</span> +<span class="r-out co"><span class="r-pr">#></span> </span> +<span class="r-out co"><span class="r-pr">#></span> Data:</span> +<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> +<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.5 1.021e+02 -0.56248</span> +<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.2 1.021e+02 -0.86248</span> +<span class="r-out co"><span class="r-pr">#></span> 1 parent 53.9 4.873e+01 5.17118</span> +<span class="r-out co"><span class="r-pr">#></span> 1 parent 47.5 4.873e+01 -1.22882</span> +<span class="r-out co"><span class="r-pr">#></span> 3 parent 10.4 1.111e+01 -0.70773</span> +<span class="r-out co"><span class="r-pr">#></span> 3 parent 7.6 1.111e+01 -3.50773</span> +<span class="r-out co"><span class="r-pr">#></span> 7 parent 1.1 5.772e-01 0.52283</span> +<span class="r-out co"><span class="r-pr">#></span> 7 parent 0.3 5.772e-01 -0.27717</span> +<span class="r-out co"><span class="r-pr">#></span> 14 parent 3.5 3.264e-03 3.49674</span> +<span class="r-out co"><span class="r-pr">#></span> 28 parent 3.2 1.045e-07 3.20000</span> +<span class="r-out co"><span class="r-pr">#></span> 90 parent 0.6 9.530e-10 0.60000</span> +<span class="r-out co"><span class="r-pr">#></span> 120 parent 3.5 -5.940e-10 3.50000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 M1 36.4 3.479e+01 1.61088</span> +<span class="r-out co"><span class="r-pr">#></span> 1 M1 37.4 3.479e+01 2.61088</span> +<span class="r-out co"><span class="r-pr">#></span> 3 M1 34.3 3.937e+01 -5.07027</span> +<span class="r-out co"><span class="r-pr">#></span> 3 M1 39.8 3.937e+01 0.42973</span> +<span class="r-out co"><span class="r-pr">#></span> 7 M1 15.1 1.549e+01 -0.38715</span> +<span class="r-out co"><span class="r-pr">#></span> 7 M1 17.8 1.549e+01 2.31285</span> +<span class="r-out co"><span class="r-pr">#></span> 14 M1 5.8 1.995e+00 3.80469</span> +<span class="r-out co"><span class="r-pr">#></span> 14 M1 1.2 1.995e+00 -0.79531</span> +<span class="r-out co"><span class="r-pr">#></span> 60 M1 0.5 2.111e-06 0.50000</span> +<span class="r-out co"><span class="r-pr">#></span> 90 M1 3.2 -9.670e-10 3.20000</span> +<span class="r-out co"><span class="r-pr">#></span> 120 M1 1.5 7.670e-10 1.50000</span> +<span class="r-out co"><span class="r-pr">#></span> 120 M1 0.6 7.670e-10 0.60000</span> +<span class="r-out co"><span class="r-pr">#></span> 1 M2 4.8 4.455e+00 0.34517</span> +<span class="r-out co"><span class="r-pr">#></span> 3 M2 20.9 2.153e+01 -0.62527</span> +<span class="r-out co"><span class="r-pr">#></span> 3 M2 19.3 2.153e+01 -2.22527</span> +<span class="r-out co"><span class="r-pr">#></span> 7 M2 42.0 4.192e+01 0.07941</span> +<span class="r-out co"><span class="r-pr">#></span> 7 M2 43.1 4.192e+01 1.17941</span> +<span class="r-out co"><span class="r-pr">#></span> 14 M2 49.4 4.557e+01 3.83353</span> +<span class="r-out co"><span class="r-pr">#></span> 14 M2 44.3 4.557e+01 -1.26647</span> +<span class="r-out co"><span class="r-pr">#></span> 28 M2 34.6 3.547e+01 -0.87275</span> +<span class="r-out co"><span class="r-pr">#></span> 28 M2 33.0 3.547e+01 -2.47275</span> +<span class="r-out co"><span class="r-pr">#></span> 60 M2 18.8 1.858e+01 0.21837</span> +<span class="r-out co"><span class="r-pr">#></span> 60 M2 17.6 1.858e+01 -0.98163</span> +<span class="r-out co"><span class="r-pr">#></span> 90 M2 10.6 1.013e+01 0.47130</span> +<span class="r-out co"><span class="r-pr">#></span> 90 M2 10.8 1.013e+01 0.67130</span> +<span class="r-out co"><span class="r-pr">#></span> 120 M2 9.8 5.521e+00 4.27893</span> +<span class="r-out co"><span class="r-pr">#></span> 120 M2 3.3 5.521e+00 -2.22107</span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 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class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -88,8 +32,7 @@ <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -99,6 +42,9 @@ <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -113,30 +59,23 @@ <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Three experimental datasets from two water sediment systems and one soil</h1> @@ -149,113 +88,123 @@ software packages (Ranke, 2014).</p> </div> - <pre class="usage"><span class='va'>test_data_from_UBA_2014</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="va">test_data_from_UBA_2014</span></code></pre></div> + </div> + <div id="format"> + <h2>Format</h2> + <p>A list containing three datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>. + Each dataset has, among others, the following components</p><dl><dt><code>title</code></dt> +<dd><p>The name of the dataset, e.g. <code>UBA_2014_WS_river</code></p></dd> - <h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2> + <dt><code>data</code></dt> +<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - <p>A list containing three datasets as an R6 class defined by <code><a href='mkinds.html'>mkinds</a></code>. - Each dataset has, among others, the following components</p><dl> - <dt><code>title</code></dt><dd><p>The name of the dataset, e.g. <code>UBA_2014_WS_river</code></p></dd> - <dt><code>data</code></dt><dd><p>A data frame with the data in the form expected by <code><a href='mkinfit.html'>mkinfit</a></code></p></dd> -</dl> - - <h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2> - +</dl></div> + <div id="source"> + <h2>Source</h2> <p>Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> <span class='co'># \dontrun{</span> - <span class='co'># This is a level P-II evaluation of the dataset according to the FOCUS kinetics</span> - <span class='co'># guidance. Due to the strong correlation of the parameter estimates, the</span> - <span class='co'># covariance matrix is not returned. Note that level P-II evaluations are</span> - <span class='co'># generally considered deprecated due to the frequent occurrence of such</span> - <span class='co'># large parameter correlations, among other reasons (e.g. the adequacy of the</span> - <span class='co'># model).</span> - <span class='va'>m_ws</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent_w <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"parent_s"</span><span class='op'>)</span>, - parent_s <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"parent_w"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> <span class='va'>f_river</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_ws</span>, <span class='va'>test_data_from_UBA_2014</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>f_river</span><span class='op'>)</span> -</div><div class='img'><img src='test_data_from_UBA_2014-1.png' alt='' width='700' height='433' /></div><div class='input'> - <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>f_river</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span> -</div><div class='output co'>#> <span class='warning'>Warning: Could not calculate correlation; no covariance matrix</span></div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower Upper -#> parent_w_0 95.91998118 NA NA NA NA NA -#> k_parent_w 0.41145375 NA NA NA NA NA -#> k_parent_s 0.04663944 NA NA NA NA NA -#> f_parent_w_to_parent_s 0.12467894 NA NA NA NA NA -#> f_parent_s_to_parent_w 0.50000000 NA NA NA NA NA -#> sigma 3.13612618 NA NA NA NA NA</div><div class='input'> <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span><span class='op'>(</span><span class='va'>f_river</span><span class='op'>)</span> -</div><div class='output co'>#> err.min n.optim df -#> All data 0.1090929 5 6 -#> parent_w 0.0817436 3 3 -#> parent_s 0.1619965 2 3</div><div class='input'> - <span class='co'># This is the evaluation used for the validation of software packages</span> - <span class='co'># in the expertise from 2014</span> - <span class='va'>m_soil</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"M1"</span>, <span class='st'>"M2"</span><span class='op'>)</span><span class='op'>)</span>, - M1 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M3"</span><span class='op'>)</span>, - M2 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='st'>"M3"</span><span class='op'>)</span>, - M3 <span class='op'>=</span> <span class='fu'><a href='mkinmod.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> - <span class='va'>f_soil</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>m_soil</span>, <span class='va'>test_data_from_UBA_2014</span><span class='op'>[[</span><span class='fl'>3</span><span class='op'>]</span><span class='op'>]</span><span class='op'>$</span><span class='va'>data</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='warning'>Warning: Observations with value of zero were removed from the data</span></div><div class='input'> <span class='fu'><a href='plot.mkinfit.html'>plot_sep</a></span><span class='op'>(</span><span class='va'>f_soil</span>, lpos <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"topright"</span>, <span class='st'>"bottomright"</span><span class='op'>)</span><span class='op'>)</span> -</div><div class='img'><img src='test_data_from_UBA_2014-2.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>f_soil</span><span class='op'>)</span><span class='op'>$</span><span class='va'>bpar</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower -#> parent_0 76.55425650 0.859186399 89.1008710 1.113861e-26 74.755959418 -#> k_parent 0.12081956 0.004601918 26.2541722 1.077359e-16 0.111561575 -#> k_M1 0.84258615 0.806160102 1.0451846 1.545268e-01 0.113779609 -#> k_M2 0.04210880 0.017083034 2.4649483 1.170188e-02 0.018013857 -#> k_M3 0.01122918 0.007245856 1.5497385 6.885052e-02 0.002909431 -#> f_parent_to_M1 0.32240200 0.240783943 1.3389680 9.819076e-02 NA -#> f_parent_to_M2 0.16099855 0.033691952 4.7785464 6.531136e-05 NA -#> f_M1_to_M3 0.27921507 0.269423780 1.0363416 1.565267e-01 0.022978205 -#> f_M2_to_M3 0.55641252 0.595119966 0.9349586 1.807707e-01 0.008002509 -#> sigma 1.14005399 0.149696423 7.6157731 1.727024e-07 0.826735778 -#> Upper -#> parent_0 78.35255358 -#> k_parent 0.13084582 -#> k_M1 6.23970702 -#> k_M2 0.09843260 -#> k_M3 0.04333992 -#> f_parent_to_M1 NA -#> f_parent_to_M2 NA -#> f_M1_to_M3 0.86450775 -#> f_M2_to_M3 0.99489895 -#> sigma 1.45337221</div><div class='input'> <span class='fu'><a href='mkinerrmin.html'>mkinerrmin</a></span><span class='op'>(</span><span class='va'>f_soil</span><span class='op'>)</span> -</div><div class='output co'>#> err.min n.optim df -#> All data 0.09649963 9 20 -#> parent 0.04721283 2 6 -#> M1 0.26551208 2 5 -#> M2 0.20327575 2 5 -#> M3 0.05196550 3 4</div><div class='input'> <span class='co'># }</span> -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"> <span class="co"># \dontrun{</span></span> +<span class="r-in"> <span class="co"># This is a level P-II evaluation of the dataset according to the FOCUS kinetics</span></span> +<span class="r-in"> <span class="co"># guidance. Due to the strong correlation of the parameter estimates, the</span></span> +<span class="r-in"> <span class="co"># covariance matrix is not returned. Note that level P-II evaluations are</span></span> +<span class="r-in"> <span class="co"># generally considered deprecated due to the frequent occurrence of such</span></span> +<span class="r-in"> <span class="co"># large parameter correlations, among other reasons (e.g. the adequacy of the</span></span> +<span class="r-in"> <span class="co"># model).</span></span> +<span class="r-in"> <span class="va">m_ws</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent_w <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"parent_s"</span><span class="op">)</span>,</span> +<span class="r-in"> parent_s <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"parent_w"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"> <span class="va">f_river</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_ws</span>, <span class="va">test_data_from_UBA_2014</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span></span> +<span class="r-plt img"><img src="test_data_from_UBA_2014-1.png" alt="" width="700" height="433"></span> +<span class="r-in"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_w_0 95.91998118 NA NA NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_w 0.41145375 NA NA NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_s 0.04663944 NA NA NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_w_to_parent_s 0.12467894 NA NA NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_s_to_parent_w 0.50000000 NA NA NA NA NA</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.13612618 NA NA NA NA NA</span> +<span class="r-in"> <span class="fu"><a href="mkinerrmin.html">mkinerrmin</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 0.1090929 5 6</span> +<span class="r-out co"><span class="r-pr">#></span> parent_w 0.0817436 3 3</span> +<span class="r-out co"><span class="r-pr">#></span> parent_s 0.1619965 2 3</span> +<span class="r-in"></span> +<span class="r-in"> <span class="co"># This is the evaluation used for the validation of software packages</span></span> +<span class="r-in"> <span class="co"># in the expertise from 2014</span></span> +<span class="r-in"> <span class="va">m_soil</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> +<span class="r-in"> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M3"</span><span class="op">)</span>,</span> +<span class="r-in"> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M3"</span><span class="op">)</span>,</span> +<span class="r-in"> M3 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"> <span class="va">f_soil</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_soil</span>, <span class="va">test_data_from_UBA_2014</span><span class="op">[[</span><span class="fl">3</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_soil</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"topright"</span>, <span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span> +<span class="r-plt img"><img src="test_data_from_UBA_2014-2.png" alt="" width="700" height="433"></span> +<span class="r-in"> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_soil</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 76.55425650 0.859186399 89.1008710 1.113861e-26 74.755959418</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.12081956 0.004601918 26.2541722 1.077359e-16 0.111561575</span> +<span class="r-out co"><span class="r-pr">#></span> k_M1 0.84258615 0.806160102 1.0451846 1.545268e-01 0.113779609</span> +<span class="r-out co"><span class="r-pr">#></span> k_M2 0.04210880 0.017083034 2.4649483 1.170188e-02 0.018013857</span> +<span class="r-out co"><span class="r-pr">#></span> k_M3 0.01122918 0.007245856 1.5497385 6.885052e-02 0.002909431</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.32240200 0.240783943 1.3389680 9.819076e-02 NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 0.16099855 0.033691952 4.7785464 6.531136e-05 NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M3 0.27921507 0.269423780 1.0363416 1.565267e-01 0.022978205</span> +<span class="r-out co"><span class="r-pr">#></span> f_M2_to_M3 0.55641252 0.595119966 0.9349586 1.807707e-01 0.008002509</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.14005399 0.149696423 7.6157731 1.727024e-07 0.826735778</span> +<span class="r-out co"><span class="r-pr">#></span> Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 78.35255358</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.13084582</span> +<span class="r-out co"><span class="r-pr">#></span> k_M1 6.23970702</span> +<span class="r-out co"><span class="r-pr">#></span> k_M2 0.09843260</span> +<span class="r-out co"><span class="r-pr">#></span> k_M3 0.04333992</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 NA</span> +<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M3 0.86450775</span> +<span class="r-out co"><span class="r-pr">#></span> f_M2_to_M3 0.99489895</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 1.45337221</span> +<span class="r-in"> <span class="fu"><a href="mkinerrmin.html">mkinerrmin</a></span><span class="op">(</span><span class="va">f_soil</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> +<span class="r-out co"><span class="r-pr">#></span> All data 0.09649963 9 20</span> +<span class="r-out co"><span class="r-pr">#></span> parent 0.04721283 2 6</span> +<span class="r-out co"><span class="r-pr">#></span> M1 0.26551208 2 5</span> +<span class="r-out co"><span class="r-pr">#></span> M2 0.20327575 2 5</span> +<span class="r-out co"><span class="r-pr">#></span> M3 0.05196550 3 4</span> +<span class="r-in"> <span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/tffm0.html b/docs/reference/tffm0.html new file mode 100644 index 00000000..bc033fb3 --- /dev/null +++ b/docs/reference/tffm0.html @@ -0,0 +1,165 @@ +<!DOCTYPE html> +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Transform formation fractions as in the first published mkin version — tffm0 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Transform formation fractions as in the first published mkin version — tffm0"><meta property="og:description" content="This transformation was used originally in mkin, in order to implement a +constraint for the sum of formation fractions to be smaller than 1. It was +later replaced by the ilr transformation because the ilr transformed +fractions can assumed to follow normal distribution. As the ilr +transformation is not available in RxODE and can therefore not be used in +the nlmixr modelling language, the original transformation is currently used +for translating mkin models with formation fractions to more than one target +compartment for fitting with nlmixr in nlmixr_model. However, this +implementation cannot be used there, as it is not accessible from RxODE."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> +<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> +<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + + + <div class="container template-reference-topic"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <div class="container"> + <div class="navbar-header"> + <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> + <span class="sr-only">Toggle navigation</span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + <span class="icon-bar"></span> + </button> + <span class="navbar-brand"> + <a class="navbar-link" href="../index.html">mkin</a> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> + </span> + </div> + + <div id="navbar" class="navbar-collapse collapse"> + <ul class="nav navbar-nav"><li> + <a href="../reference/index.html">Functions and data</a> +</li> +<li class="dropdown"> + <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> + Articles + + <span class="caret"></span> + </a> + <ul class="dropdown-menu" role="menu"><li> + <a href="../articles/mkin.html">Introduction to mkin</a> + </li> + <li> + <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> + </li> + <li> + <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> + </li> + <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> + <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> + </li> + <li> + <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> + </li> + <li> + <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> + </li> + <li> + <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> + </li> + <li> + <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> + </li> + </ul></li> +<li> + <a href="../news/index.html">News</a> +</li> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> + <span class="fab fa-github fa-lg"></span> + + </a> +</li> + </ul></div><!--/.nav-collapse --> + </div><!--/.container --> +</div><!--/.navbar --> + + + + </header><div class="row"> + <div class="col-md-9 contents"> + <div class="page-header"> + <h1>Transform formation fractions as in the first published mkin version</h1> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/tffm0.R" class="external-link"><code>R/tffm0.R</code></a></small> + <div class="hidden name"><code>tffm0.Rd</code></div> + </div> + + <div class="ref-description"> + <p>This transformation was used originally in mkin, in order to implement a +constraint for the sum of formation fractions to be smaller than 1. It was +later replaced by the <a href="ilr.html">ilr</a> transformation because the ilr transformed +fractions can assumed to follow normal distribution. As the ilr +transformation is not available in <a href="https://nlmixrdevelopment.github.io/RxODE/reference/RxODE.html" class="external-link">RxODE</a> and can therefore not be used in +the nlmixr modelling language, the original transformation is currently used +for translating mkin models with formation fractions to more than one target +compartment for fitting with nlmixr in <a href="nlmixr.mmkin.html">nlmixr_model</a>. However, this +implementation cannot be used there, as it is not accessible from RxODE.</p> + </div> + + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">tffm0</span><span class="op">(</span><span class="va">ff</span><span class="op">)</span> + +<span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_trans</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>ff</dt> +<dd><p>Vector of untransformed formation fractions. The sum +must be smaller or equal to one</p></dd> +<dt>ff_trans</dt> +<dd><p>Vector of transformed formation fractions that can be +restricted to the interval from 0 to 1</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> + <p>A vector of the transformed formation fractions +A vector of backtransformed formation fractions for natural use in degradation models</p> + </div> + <div id="details"> + <h2>Details</h2> + <p>If the transformed formation fractions are restricted to the interval +between 0 and 1, the sum of backtransformed values is restricted +to this interval.</p> + </div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">ff_example</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> +<span class="r-in"> <span class="fl">0.10983681</span>, <span class="fl">0.09035905</span>, <span class="fl">0.08399383</span></span> +<span class="r-in"><span class="op">)</span></span> +<span class="r-in"><span class="va">ff_example_trans</span> <span class="op"><-</span> <span class="fu">tffm0</span><span class="op">(</span><span class="va">ff_example</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_example_trans</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> [1] 0.10983681 0.09035905 0.08399383</span> +</code></pre></div> + </div> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> +</div> + + + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> +</div> + +<div class="pkgdown"> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> +</div> + + </footer></div> + + + + + + + </body></html> + diff --git a/docs/reference/transform_odeparms.html b/docs/reference/transform_odeparms.html index bbaad91e..25d0e76b 100644 --- a/docs/reference/transform_odeparms.html +++ b/docs/reference/transform_odeparms.html @@ -1,72 +1,17 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous" /> - -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script> - -<!-- bootstrap-toc --> -<link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script> - -<!-- Font Awesome icons --> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous" /> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" /> - -<!-- clipboard.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script> - -<!-- headroom.js --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script> - -<!-- pkgdown --> -<link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script> - - - - -<meta property="og:title" content="Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms" /> -<meta property="og:description" content="The transformations are intended to map parameters that should only take on +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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For kinetic rate constants and other parameters that can only take on positive values, a simple log transformation is used. For compositional parameters, such as the formations fractions that should always sum up to 1 and can not be negative, -the ilr transformation is used." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +the ilr transformation is used."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - - - </head> +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -77,13 +22,12 @@ the ilr transformation is used." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.4</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -92,8 +36,7 @@ the ilr transformation is used." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -103,6 +46,9 @@ the ilr transformation is used." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -117,34 +63,27 @@ the ilr transformation is used." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Functions to transform and backtransform kinetic parameters for fitting</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/transform_odeparms.R'><code>R/transform_odeparms.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/transform_odeparms.R" class="external-link"><code>R/transform_odeparms.R</code></a></small> <div class="hidden name"><code>transform_odeparms.Rd</code></div> </div> @@ -154,205 +93,210 @@ restricted values to the full scale of real numbers. For kinetic rate constants and other parameters that can only take on positive values, a simple log transformation is used. For compositional parameters, such as the formations fractions that should always sum up to 1 and can not be negative, -the <a href='ilr.html'>ilr</a> transformation is used.</p> +the <a href="ilr.html">ilr</a> transformation is used.</p> </div> - <pre class="usage"><span class='fu'>transform_odeparms</span><span class='op'>(</span> - <span class='va'>parms</span>, - <span class='va'>mkinmod</span>, - transform_rates <span class='op'>=</span> <span class='cn'>TRUE</span>, - transform_fractions <span class='op'>=</span> <span class='cn'>TRUE</span> -<span class='op'>)</span> - -<span class='fu'>backtransform_odeparms</span><span class='op'>(</span> - <span class='va'>transparms</span>, - <span class='va'>mkinmod</span>, - transform_rates <span class='op'>=</span> <span class='cn'>TRUE</span>, - transform_fractions <span class='op'>=</span> <span class='cn'>TRUE</span> -<span class='op'>)</span></pre> + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">transform_odeparms</span><span class="op">(</span> + <span class="va">parms</span>, + <span class="va">mkinmod</span>, + transform_rates <span class="op">=</span> <span class="cn">TRUE</span>, + transform_fractions <span class="op">=</span> <span class="cn">TRUE</span> +<span class="op">)</span> + +<span class="fu">backtransform_odeparms</span><span class="op">(</span> + <span class="va">transparms</span>, + <span class="va">mkinmod</span>, + transform_rates <span class="op">=</span> <span class="cn">TRUE</span>, + transform_fractions <span class="op">=</span> <span class="cn">TRUE</span> +<span class="op">)</span></code></pre></div> + </div> - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>parms</th> - <td><p>Parameters of kinetic models as used in the differential -equations.</p></td> - </tr> - <tr> - <th>mkinmod</th> - <td><p>The kinetic model of class <a href='mkinmod.html'>mkinmod</a>, containing + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>parms</dt> +<dd><p>Parameters of kinetic models as used in the differential +equations.</p></dd> +<dt>mkinmod</dt> +<dd><p>The kinetic model of class <a href="mkinmod.html">mkinmod</a>, containing the names of the model variables that are needed for grouping the -formation fractions before <a href='ilr.html'>ilr</a> transformation, the parameter -names and the information if the pathway to sink is included in the model.</p></td> - </tr> - <tr> - <th>transform_rates</th> - <td><p>Boolean specifying if kinetic rate constants should +formation fractions before <a href="ilr.html">ilr</a> transformation, the parameter +names and the information if the pathway to sink is included in the model.</p></dd> +<dt>transform_rates</dt> +<dd><p>Boolean specifying if kinetic rate constants should be transformed in the model specification used in the fitting for better compliance with the assumption of normal distribution of the estimator. If TRUE, also alpha and beta parameters of the FOMC model are log-transformed, as well as k1 and k2 rate constants for the DFOP and HS -models and the break point tb of the HS model.</p></td> - </tr> - <tr> - <th>transform_fractions</th> - <td><p>Boolean specifying if formation fractions +models and the break point tb of the HS model.</p></dd> +<dt>transform_fractions</dt> +<dd><p>Boolean specifying if formation fractions constants should be transformed in the model specification used in the fitting for better compliance with the assumption of normal distribution of the estimator. The default (TRUE) is to do transformations. The g parameter of the DFOP model is also seen as a fraction. If a single fraction is transformed (g parameter of DFOP or only a single target variable e.g. a single metabolite plus a pathway to sink), a -logistic transformation is used <code><a href='https://rdrr.io/r/stats/Logistic.html'>stats::qlogis()</a></code>. In other cases, i.e. if +logistic transformation is used <code><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">stats::qlogis()</a></code>. In other cases, i.e. if two or more formation fractions need to be transformed whose sum cannot -exceed one, the <a href='ilr.html'>ilr</a> transformation is used.</p></td> - </tr> - <tr> - <th>transparms</th> - <td><p>Transformed parameters of kinetic models as used in the -fitting procedure.</p></td> - </tr> - </table> - - <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> - +exceed one, the <a href="ilr.html">ilr</a> transformation is used.</p></dd> +<dt>transparms</dt> +<dd><p>Transformed parameters of kinetic models as used in the +fitting procedure.</p></dd> +</dl></div> + <div id="value"> + <h2>Value</h2> <p>A vector of transformed or backtransformed parameters</p> - <h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2> - + </div> + <div id="details"> + <h2>Details</h2> <p>The transformation of sets of formation fractions is fragile, as it supposes the same ordering of the components in forward and backward transformation. -This is no problem for the internal use in <a href='mkinfit.html'>mkinfit</a>.</p> - <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> - +This is no problem for the internal use in <a href="mkinfit.html">mkinfit</a>.</p> + </div> + <div id="author"> + <h2>Author</h2> <p>Johannes Ranke</p> + </div> - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'> -<span class='va'>SFO_SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, use_of_ff <span class='op'>=</span> <span class='st'>"min"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='co'># Fit the model to the FOCUS example dataset D using defaults</span> -<span class='va'>FOCUS_D</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span> <span class='co'># remove zero values to avoid warning</span> -<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>fit.s</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -<span class='co'># Transformed and backtransformed parameters</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate Std. Error Lower Upper -#> parent_0 99.60 1.5702 96.40 102.79 -#> log_k_parent_sink -3.04 0.0763 -3.19 -2.88 -#> log_k_parent_m1 -2.98 0.0403 -3.06 -2.90 -#> log_k_m1_sink -5.25 0.1332 -5.52 -4.98 -#> sigma 3.13 0.3585 2.40 3.85</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower Upper -#> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 102.7931 -#> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04103 0.0560 -#> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04678 0.0551 -#> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069 -#> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</div><div class='input'> -<span class='co'># \dontrun{</span> -<span class='co'># Compare to the version without transforming rate parameters (does not work</span> -<span class='co'># with analytical solution, we get NA values for m1 in predictions)</span> -<span class='va'>fit.2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO</span>, <span class='va'>FOCUS_D</span>, transform_rates <span class='op'>=</span> <span class='cn'>FALSE</span>, - solution_type <span class='op'>=</span> <span class='st'>"deSolve"</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>fit.2.s</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.2</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.2.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate Std. Error Lower Upper -#> parent_0 99.59848 1.57022 96.40384 1.03e+02 -#> k_parent_sink 0.04792 0.00365 0.04049 5.54e-02 -#> k_parent_m1 0.05078 0.00205 0.04661 5.49e-02 -#> k_m1_sink 0.00526 0.00070 0.00384 6.69e-03 -#> sigma 3.12550 0.35852 2.39609 3.85e+00</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.2.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower Upper -#> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 1.03e+02 -#> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04049 5.54e-02 -#> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04661 5.49e-02 -#> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00384 6.69e-03 -#> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.85e+00</div><div class='input'><span class='co'># }</span> - -<span class='va'>initials</span> <span class='op'><-</span> <span class='va'>fit</span><span class='op'>$</span><span class='va'>start</span><span class='op'>$</span><span class='va'>value</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>initials</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/colnames.html'>rownames</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>start</span><span class='op'>)</span> -<span class='va'>transformed</span> <span class='op'><-</span> <span class='va'>fit</span><span class='op'>$</span><span class='va'>start_transformed</span><span class='op'>$</span><span class='va'>value</span> -<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>transformed</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/colnames.html'>rownames</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>$</span><span class='va'>start_transformed</span><span class='op'>)</span> -<span class='fu'>transform_odeparms</span><span class='op'>(</span><span class='va'>initials</span>, <span class='va'>SFO_SFO</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 log_k_parent_sink log_k_parent_m1 log_k_m1_sink -#> 100.750000 -2.302585 -2.301586 -2.300587 </div><div class='input'><span class='fu'>backtransform_odeparms</span><span class='op'>(</span><span class='va'>transformed</span>, <span class='va'>SFO_SFO</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 k_parent_sink k_parent_m1 k_m1_sink -#> 100.7500 0.1000 0.1001 0.1002 </div><div class='input'> -<span class='co'># \dontrun{</span> -<span class='co'># The case of formation fractions (this is now the default)</span> -<span class='va'>SFO_SFO.ff</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> -<span class='va'>fit.ff</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.ff</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>fit.ff.s</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.ff</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate Std. Error Lower Upper -#> parent_0 99.5985 1.5702 96.404 102.79 -#> log_k_parent -2.3157 0.0409 -2.399 -2.23 -#> log_k_m1 -5.2475 0.1332 -5.518 -4.98 -#> f_parent_qlogis 0.0579 0.0893 -0.124 0.24 -#> sigma 3.1255 0.3585 2.396 3.85</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower Upper -#> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40383 102.7931 -#> k_parent 0.09870 0.00403 24.47 4.96e-23 0.09082 0.1073 -#> k_m1 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069 -#> f_parent_to_m1 0.51448 0.02230 23.07 3.10e-22 0.46912 0.5596 -#> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</div><div class='input'><span class='va'>initials</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"f_parent_to_m1"</span> <span class='op'>=</span> <span class='fl'>0.5</span><span class='op'>)</span> -<span class='va'>transformed</span> <span class='op'><-</span> <span class='fu'>transform_odeparms</span><span class='op'>(</span><span class='va'>initials</span>, <span class='va'>SFO_SFO.ff</span><span class='op'>)</span> -<span class='fu'>backtransform_odeparms</span><span class='op'>(</span><span class='va'>transformed</span>, <span class='va'>SFO_SFO.ff</span><span class='op'>)</span> -</div><div class='output co'>#> f_parent_to_m1 -#> 0.5 </div><div class='input'> -<span class='co'># And without sink</span> -<span class='va'>SFO_SFO.ff.2</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span> - parent <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span>, to <span class='op'>=</span> <span class='st'>"m1"</span>, sink <span class='op'>=</span> <span class='cn'>FALSE</span><span class='op'>)</span>, - m1 <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span><span class='op'>(</span>type <span class='op'>=</span> <span class='st'>"SFO"</span><span class='op'>)</span>, - use_of_ff <span class='op'>=</span> <span class='st'>"max"</span><span class='op'>)</span> -</div><div class='output co'>#> <span class='message'>Temporary DLL for differentials generated and loaded</span></div><div class='input'> - -<span class='va'>fit.ff.2</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='va'>SFO_SFO.ff.2</span>, <span class='va'>FOCUS_D</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='va'>fit.ff.2.s</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/summary.html'>summary</a></span><span class='op'>(</span><span class='va'>fit.ff.2</span><span class='op'>)</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.2.s</span><span class='op'>$</span><span class='va'>par</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate Std. Error Lower Upper -#> parent_0 84.79 3.012 78.67 90.91 -#> log_k_parent -2.76 0.082 -2.92 -2.59 -#> log_k_m1 -4.21 0.123 -4.46 -3.96 -#> sigma 8.22 0.943 6.31 10.14</div><div class='input'><span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>fit.ff.2.s</span><span class='op'>$</span><span class='va'>bpar</span>, <span class='fl'>3</span><span class='op'>)</span> -</div><div class='output co'>#> Estimate se_notrans t value Pr(>t) Lower Upper -#> parent_0 84.7916 3.01203 28.15 1.92e-25 78.6704 90.913 -#> k_parent 0.0635 0.00521 12.19 2.91e-14 0.0538 0.075 -#> k_m1 0.0148 0.00182 8.13 8.81e-10 0.0115 0.019 -#> sigma 8.2229 0.94323 8.72 1.73e-10 6.3060 10.140</div><div class='input'><span class='co'># }</span> - -</div></pre> + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"></span> +<span class="r-in"><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"min"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># Fit the model to the FOCUS example dataset D using defaults</span></span> +<span class="r-in"><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># remove zero values to avoid warning</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-in"><span class="co"># Transformed and backtransformed parameters</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.60 1.5702 96.40 102.79</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink -3.04 0.0763 -3.19 -2.88</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent_m1 -2.98 0.0403 -3.06 -2.90</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1_sink -5.25 0.1332 -5.52 -4.98</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.13 0.3585 2.40 3.85</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 102.7931</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04103 0.0560</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04678 0.0551</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="co"># Compare to the version without transforming rate parameters (does not work</span></span> +<span class="r-in"><span class="co"># with analytical solution, we get NA values for m1 in predictions)</span></span> +<span class="r-in"><span class="va">fit.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, transform_rates <span class="op">=</span> <span class="cn">FALSE</span>,</span> +<span class="r-in"> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit.2.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.2.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 96.40384 1.03e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 0.04049 5.54e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 0.04661 5.49e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 0.00384 6.69e-03</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 2.39609 3.85e+00</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.2.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 1.03e+02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04049 5.54e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04661 5.49e-02</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00384 6.69e-03</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.85e+00</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">initials</span> <span class="op"><-</span> <span class="va">fit</span><span class="op">$</span><span class="va">start</span><span class="op">$</span><span class="va">value</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">initials</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">start</span><span class="op">)</span></span> +<span class="r-in"><span class="va">transformed</span> <span class="op"><-</span> <span class="va">fit</span><span class="op">$</span><span class="va">start_transformed</span><span class="op">$</span><span class="va">value</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">transformed</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">start_transformed</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">transform_odeparms</span><span class="op">(</span><span class="va">initials</span>, <span class="va">SFO_SFO</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_m1 log_k_m1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 100.750000 -2.302585 -2.301586 -2.300587 </span> +<span class="r-in"><span class="fu">backtransform_odeparms</span><span class="op">(</span><span class="va">transformed</span>, <span class="va">SFO_SFO</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent_sink k_parent_m1 k_m1_sink </span> +<span class="r-out co"><span class="r-pr">#></span> 100.7500 0.1000 0.1001 0.1002 </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="co"># The case of formation fractions (this is now the default)</span></span> +<span class="r-in"><span class="va">SFO_SFO.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"><span class="va">fit.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit.ff.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.ff</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.5985 1.5702 96.404 102.79</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.3157 0.0409 -2.399 -2.23</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -5.2475 0.1332 -5.518 -4.98</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.0579 0.0893 -0.124 0.24</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.1255 0.3585 2.396 3.85</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40383 102.7931</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.09870 0.00403 24.47 4.96e-23 0.09082 0.1073</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069</span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.51448 0.02230 23.07 3.10e-22 0.46912 0.5596</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</span> +<span class="r-in"><span class="va">initials</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"f_parent_to_m1"</span> <span class="op">=</span> <span class="fl">0.5</span><span class="op">)</span></span> +<span class="r-in"><span class="va">transformed</span> <span class="op"><-</span> <span class="fu">transform_odeparms</span><span class="op">(</span><span class="va">initials</span>, <span class="va">SFO_SFO.ff</span><span class="op">)</span></span> +<span class="r-in"><span class="fu">backtransform_odeparms</span><span class="op">(</span><span class="va">transformed</span>, <span class="va">SFO_SFO.ff</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 </span> +<span class="r-out co"><span class="r-pr">#></span> 0.5 </span> +<span class="r-in"></span> +<span class="r-in"><span class="co"># And without sink</span></span> +<span class="r-in"><span class="va">SFO_SFO.ff.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span> +<span class="r-in"> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> +<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span> +<span class="r-in"> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span> +<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> +<span class="r-in"></span> +<span class="r-in"></span> +<span class="r-in"><span class="va">fit.ff.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff.2</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="va">fit.ff.2.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.ff.2</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.2.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 84.79 3.012 78.67 90.91</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.76 0.082 -2.92 -2.59</span> +<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -4.21 0.123 -4.46 -3.96</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 8.22 0.943 6.31 10.14</span> +<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.2.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 84.7916 3.01203 28.15 1.92e-25 78.6704 90.913</span> +<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0635 0.00521 12.19 2.91e-14 0.0538 0.075</span> +<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0148 0.00182 8.13 8.81e-10 0.0115 0.019</span> +<span class="r-out co"><span class="r-pr">#></span> sigma 8.2229 0.94323 8.72 1.73e-10 6.3060 10.140</span> +<span class="r-in"><span class="co"># }</span></span> +<span class="r-in"></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/reference/update.mkinfit-1.png b/docs/reference/update.mkinfit-1.png Binary files differindex df8473c1..12fe1f5b 100644 --- a/docs/reference/update.mkinfit-1.png +++ b/docs/reference/update.mkinfit-1.png diff --git a/docs/reference/update.mkinfit-2.png b/docs/reference/update.mkinfit-2.png Binary files differindex 13c99b44..21817f94 100644 --- a/docs/reference/update.mkinfit-2.png +++ b/docs/reference/update.mkinfit-2.png diff --git a/docs/reference/update.mkinfit.html b/docs/reference/update.mkinfit.html index 09050e53..036283d5 100644 --- a/docs/reference/update.mkinfit.html +++ b/docs/reference/update.mkinfit.html @@ -1,70 +1,15 @@ -<!-- Generated by pkgdown: do not edit by hand --> <!DOCTYPE html> -<html lang="en"> - 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The fitted degradation +<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Update an mkinfit model with different arguments — update.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Update an mkinfit model with different arguments — update.mkinfit"><meta property="og:description" content="This function will return an updated mkinfit object. The fitted degradation model parameters from the old fit are used as starting values for the updated fit. Values specified as 'parms.ini' and/or 'state.ini' will -override these starting values." /> - - - - -<!-- mathjax --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script> -<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script> - -<!--[if lt IE 9]> +override these starting values."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> - - +<![endif]--></head><body data-spy="scroll" data-target="#toc"> + - </head> - - <body data-spy="scroll" data-target="#toc"> <div class="container template-reference-topic"> - <header> - <div class="navbar navbar-default navbar-fixed-top" role="navigation"> + <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> @@ -75,13 +20,12 @@ override these starting values." /> </button> <span class="navbar-brand"> <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.0.3</span> + <span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">1.1.0</span> </span> </div> <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> - <li> + <ul class="nav navbar-nav"><li> <a href="../reference/index.html">Functions and data</a> </li> <li class="dropdown"> @@ -90,8 +34,7 @@ override these starting values." /> <span class="caret"></span> </a> - <ul class="dropdown-menu" role="menu"> - <li> + <ul class="dropdown-menu" role="menu"><li> <a href="../articles/mkin.html">Introduction to mkin</a> </li> <li> @@ -101,6 +44,9 @@ override these starting values." /> <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> </li> <li> + <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> + </li> + <li> <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> </li> <li> @@ -115,34 +61,27 @@ override these starting values." /> <li> <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> </li> - </ul> -</li> + </ul></li> <li> <a href="../news/index.html">News</a> </li> - </ul> - <ul class="nav navbar-nav navbar-right"> - <li> - <a href="https://github.com/jranke/mkin/"> + </ul><ul class="nav navbar-nav navbar-right"><li> + <a href="https://github.com/jranke/mkin/" class="external-link"> <span class="fab fa-github fa-lg"></span> </a> </li> - </ul> - - </div><!--/.nav-collapse --> + </ul></div><!--/.nav-collapse --> </div><!--/.container --> </div><!--/.navbar --> - </header> - -<div class="row"> + </header><div class="row"> <div class="col-md-9 contents"> <div class="page-header"> <h1>Update an mkinfit model with different arguments</h1> - <small class="dont-index">Source: <a href='https://github.com/jranke/mkin/blob/master/R/update.mkinfit.R'><code>R/update.mkinfit.R</code></a></small> + <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/update.mkinfit.R" class="external-link"><code>R/update.mkinfit.R</code></a></small> <div class="hidden name"><code>update.mkinfit.Rd</code></div> </div> @@ -153,66 +92,62 @@ updated fit. Values specified as 'parms.ini' and/or 'state.ini' will override these starting values.</p> </div> - <pre class="usage"><span class='co'># S3 method for mkinfit</span> -<span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>object</span>, <span class='va'>...</span>, evaluate <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>object</th> - <td><p>An mkinfit object to be updated</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Arguments to <code><a href='mkinfit.html'>mkinfit</a></code> that should replace + <div id="ref-usage"> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mkinfit</span> +<span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span>, evaluate <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></code></pre></div> + </div> + + <div id="arguments"> + <h2>Arguments</h2> + <dl><dt>object</dt> +<dd><p>An mkinfit object to be updated</p></dd> +<dt>...</dt> +<dd><p>Arguments to <code><a href="mkinfit.html">mkinfit</a></code> that should replace the arguments from the original call. Arguments set to NULL will -remove arguments given in the original call</p></td> - </tr> - <tr> - <th>evaluate</th> - <td><p>Should the call be evaluated or returned as a call</p></td> - </tr> - </table> - - - <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> - <pre class="examples"><div class='input'><span class='co'># \dontrun{</span> -<span class='va'>fit</span> <span class='op'><-</span> <span class='fu'><a href='mkinfit.html'>mkinfit</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span><span class='op'>(</span><span class='va'>FOCUS_2006_D</span>, <span class='va'>value</span> <span class='op'>!=</span> <span class='fl'>0</span><span class='op'>)</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> -<span class='fu'><a href='parms.html'>parms</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 k_parent sigma -#> 99.44423885 0.09793574 3.39632469 </div><div class='input'><span class='fu'><a href='plot.mkinfit.html'>plot_err</a></span><span class='op'>(</span><span class='va'>fit</span><span class='op'>)</span> -</div><div class='img'><img src='update.mkinfit-1.png' alt='' width='700' height='433' /></div><div class='input'><span class='va'>fit_2</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span><span class='op'>(</span><span class='va'>fit</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span><span class='op'>)</span> -<span class='fu'><a href='parms.html'>parms</a></span><span class='op'>(</span><span class='va'>fit_2</span><span class='op'>)</span> -</div><div class='output co'>#> parent_0 k_parent sigma_low rsd_high -#> 1.008549e+02 1.005665e-01 3.752222e-03 6.763434e-02 </div><div class='input'><span class='fu'><a href='plot.mkinfit.html'>plot_err</a></span><span class='op'>(</span><span class='va'>fit_2</span><span class='op'>)</span> -</div><div class='img'><img src='update.mkinfit-2.png' alt='' width='700' height='433' /></div><div class='input'><span class='co'># }</span> -</div></pre> +remove arguments given in the original call</p></dd> +<dt>evaluate</dt> +<dd><p>Should the call be evaluated or returned as a call</p></dd> +</dl></div> + + <div id="ref-examples"> + <h2>Examples</h2> + <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> +<span class="r-in"><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma </span> +<span class="r-out co"><span class="r-pr">#></span> 99.44423885 0.09793574 3.39632469 </span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_err</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span> +<span class="r-plt img"><img src="update.mkinfit-1.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">fit</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> +<span class="r-in"><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span> +<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma_low rsd_high </span> +<span class="r-out co"><span class="r-pr">#></span> 1.008549e+02 1.005665e-01 3.752222e-03 6.763434e-02 </span> +<span class="r-in"><span class="fu"><a href="plot.mkinfit.html">plot_err</a></span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span> +<span class="r-plt img"><img src="update.mkinfit-2.png" alt="" width="700" height="433"></span> +<span class="r-in"><span class="co"># }</span></span> +</code></pre></div> + </div> </div> <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 data-toc-skip>Contents</h2> - </nav> - </div> + <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> + </nav></div> </div> - <footer> - <div class="copyright"> - <p>Developed by Johannes Ranke.</p> + <footer><div class="copyright"> + <p></p><p>Developed by Johannes Ranke.</p> </div> <div class="pkgdown"> - <p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p> + <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> </div> - </footer> - </div> + </footer></div> - </body> -</html> + + </body></html> diff --git a/docs/sitemap.xml b/docs/sitemap.xml index 601a4464..f39832fb 100644 --- a/docs/sitemap.xml +++ b/docs/sitemap.xml @@ -1,9 +1,48 @@ <?xml version="1.0" encoding="UTF-8"?> <urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9"> <url> + <loc>https://pkgdown.jrwb.de/mkin/404.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/FOCUS_D.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/FOCUS_L.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/index.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/mkin.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/twa.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/FOCUS_Z.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/NAFTA_examples.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/benchmarks.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/articles/web_only/dimethenamid_2018.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/authors.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/index.html</loc> </url> <url> + <loc>https://pkgdown.jrwb.de/mkin/news/index.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/reference/AIC.mmkin.html</loc> </url> <url> @@ -88,6 +127,15 @@ <loc>https://pkgdown.jrwb.de/mkin/reference/ilr.html</loc> </url> <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/index.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/intervals.nlmixr.mmkin.html</loc> + </url> + <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/intervals.saem.mmkin.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/reference/loftest.html</loc> </url> <url> @@ -106,6 +154,9 @@ <loc>https://pkgdown.jrwb.de/mkin/reference/mccall81_245T.html</loc> </url> <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/mean_degparms.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/reference/mixed.html</loc> </url> <url> @@ -145,6 +196,9 @@ <loc>https://pkgdown.jrwb.de/mkin/reference/mkinresplot.html</loc> </url> <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/mkinsub.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/reference/mmkin.html</loc> </url> <url> @@ -157,6 +211,9 @@ <loc>https://pkgdown.jrwb.de/mkin/reference/nlme.mmkin.html</loc> </url> <url> + <loc>https://pkgdown.jrwb.de/mkin/reference/nlmixr.mmkin.html</loc> + </url> + <url> <loc>https://pkgdown.jrwb.de/mkin/reference/nobs.mkinfit.html</loc> </url> <url> @@ -175,57 +232,57 @@ <loc>https://pkgdown.jrwb.de/mkin/reference/plot.nafta.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/reexports.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/plot.nlme.mmkin.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/residuals.mkinfit.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/print.mkinds.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/schaefer07_complex_case.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/print.mkinmod.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/print.mmkin.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/summary.mkinfit.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/reexports.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/summary.nlme.mmkin.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/residuals.mkinfit.html</loc> </url> <url> - <loc>https://pkgdown.jrwb.de/mkin/reference/synthetic_data_for_UBA_2014.html</loc> + <loc>https://pkgdown.jrwb.de/mkin/reference/saem.html</loc> </url> <url> - 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+} } \seealso{ \link{summary.nlmixr.mmkin} \link{plot.mixed.mmkin} @@ -3,26 +3,26 @@ Loading required package: parallel ℹ Testing mkin ✔ | F W S OK | Context ✔ | 5 | AIC calculation -✔ | 5 | Analytical solutions for coupled models [4.3s] +✔ | 5 | Analytical solutions for coupled models [4.2s] ✔ | 5 | Calculation of Akaike weights ✔ | 2 | Export dataset for reading into CAKE -✔ | 12 | Confidence intervals and p-values [1.1s] +✔ | 12 | Confidence intervals and p-values [1.0s] ⠋ | 1 | Dimethenamid data from 2018 -✔ | 1 27 | Dimethenamid data from 2018 [62.8s] +✔ | 1 27 | Dimethenamid data from 2018 [63.0s] ──────────────────────────────────────────────────────────────────────────────── -Skip (test_dmta.R:160:3): Different backends get consistent results for SFO-SFO3+, dimethenamid data +Skip (test_dmta.R:162:3): Different backends get consistent results for SFO-SFO3+, dimethenamid data Reason: Fitting this ODE model with saemix takes about 15 minutes on my system ──────────────────────────────────────────────────────────────────────────────── -✔ | 14 | Error model fitting [7.0s] +✔ | 14 | Error model fitting [6.8s] ✔ | 5 | Time step normalisation ✔ | 4 | Calculation of FOCUS chi2 error levels [0.8s] ✔ | 14 | Results for FOCUS D established in expertise for UBA (Ranke 2014) [1.1s] -✔ | 4 | Test fitting the decline of metabolites from their maximum [0.6s] -✔ | 1 | Fitting the logistic model [0.4s] +✔ | 4 | Test fitting the decline of metabolites from their maximum [0.5s] +✔ | 1 | Fitting the logistic model [0.3s] ⠴ | 6 | Nonlinear mixed-effects models -✔ | 1 15 | Nonlinear mixed-effects models [2.5s] +✔ | 1 14 | Nonlinear mixed-effects models [1.3s] ──────────────────────────────────────────────────────────────────────────────── -Skip (test_mixed.R:67:3): saemix results are reproducible for biphasic fits +Skip (test_mixed.R:68:3): saemix results are reproducible for biphasic fits Reason: Fitting with saemix takes around 10 minutes when using deSolve ──────────────────────────────────────────────────────────────────────────────── ✔ | 3 | Test dataset classes mkinds and mkindsg @@ -31,24 +31,24 @@ Reason: Fitting with saemix takes around 10 minutes when using deSolve ✔ | 8 | mkinmod model generation and printing [0.2s] ✔ | 3 | Model predictions with mkinpredict [0.3s] ✔ | 16 | Evaluations according to 2015 NAFTA guidance [2.1s] -✔ | 9 | Nonlinear mixed-effects models with nlme [9.2s] +✔ | 9 | Nonlinear mixed-effects models with nlme [9.0s] ✔ | 16 | Plotting [1.5s] ✔ | 4 | Residuals extracted from mkinfit models -✔ | 23 | saemix_parent [29.4s] -✔ | 2 | Complex test case from Schaefer et al. (2007) Piacenza paper [1.7s] -✔ | 7 | Fitting the SFORB model [4.5s] +✔ | 23 | saemix_parent [29.8s] +✔ | 2 | Complex test case from Schaefer et al. (2007) Piacenza paper [1.6s] +✔ | 7 | Fitting the SFORB model [4.4s] ✔ | 1 | Summaries of old mkinfit objects ✔ | 4 | Summary [0.1s] -✔ | 4 | Results for synthetic data established in expertise for UBA (Ranke 2014) [2.6s] -✔ | 9 | Hypothesis tests [9.5s] +✔ | 4 | Results for synthetic data established in expertise for UBA (Ranke 2014) [2.5s] +✔ | 9 | Hypothesis tests [9.6s] ✔ | 2 | tffm0 ✔ | 4 | Calculation of maximum time weighted average concentrations (TWAs) [2.2s] ══ Results ═════════════════════════════════════════════════════════════════════ -Duration: 145.9 s +Duration: 144.7 s ── Skipped tests ────────────────────────────────────────────────────────────── • Fitting this ODE model with saemix takes about 15 minutes on my system (1) • Fitting with saemix takes around 10 minutes when using deSolve (1) -[ FAIL 0 | WARN 0 | SKIP 2 | PASS 241 ] +[ FAIL 0 | WARN 0 | SKIP 2 | PASS 240 ] diff --git 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likelihood + +Structural model: +d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * + time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) + * parent + +Data: +270 observations of 1 variable(s) grouped in 15 datasets + +Log-likelihood: -612 + +Fixed effects: + list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) +parent_0 log_k1 log_k2 g_qlogis + 100.1 -2.7 -4.1 -0.5 + +Random effects: + Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) + Level: ds + Structure: Diagonal + parent_0 log_k1 log_k2 g_qlogis Residual +StdDev: 0.4 0.3 0.2 0.2 2 + diff --git a/tests/testthat/print_mmkin_biphasic_mixed.txt b/tests/testthat/print_mmkin_biphasic_mixed.txt index 0b23fe58..712c813a 100644 --- a/tests/testthat/print_mmkin_biphasic_mixed.txt +++ b/tests/testthat/print_mmkin_biphasic_mixed.txt @@ -21,6 +21,6 @@ OK: No warnings Mean fitted parameters: parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 - 100.667 -5.378 -0.095 -2.743 -4.510 + 100.648 -5.380 -0.093 -2.736 -4.534 g_qlogis - -0.180 + -0.142 diff --git a/tests/testthat/print_nlme_biphasic.txt b/tests/testthat/print_nlme_biphasic.txt deleted file mode 100644 index f40d438d..00000000 --- a/tests/testthat/print_nlme_biphasic.txt +++ /dev/null @@ -1,29 +0,0 @@ -Kinetic nonlinear mixed-effects model fit by maximum likelihood - -Structural model: -d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * parent -d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) - * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * parent - k_m1 * m1 - -Data: -507 observations of 2 variable(s) grouped in 15 datasets - -Log-likelihood: -1326 - -Fixed effects: - list(parent_0 ~ 1, log_k_m1 ~ 1, f_parent_qlogis ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) - parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 - 100.7 -5.4 -0.1 -2.8 -4.5 - g_qlogis - -0.1 - -Random effects: - Formula: list(parent_0 ~ 1, log_k_m1 ~ 1, f_parent_qlogis ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) - Level: ds - Structure: Diagonal - parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 g_qlogis Residual -StdDev: 1 0.03 0.3 0.3 0.2 0.3 3 - diff --git a/tests/testthat/print_nlmixr_saem_biphasic.txt b/tests/testthat/print_nlmixr_saem_biphasic.txt index 5cf80f0f..ad59005d 100644 --- a/tests/testthat/print_nlmixr_saem_biphasic.txt +++ b/tests/testthat/print_nlmixr_saem_biphasic.txt @@ -12,24 +12,28 @@ Data: Likelihood: AIC BIC logLik - 2510 2569 -1241 + 2400 2468 -1184 Fitted parameters: Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD) -parent_0 100 0.444 0.442 100 (99.6, 101) 0.461 -log_k_m1 -5.36 0.0804 1.5 0.00472 (0.00403, 0.00552) 21.5 -f_parent_qlogis -0.0909 0.0868 95.5 0.477 (0.435, 0.52) 0.308 -log_k1 -2.78 0.0977 3.51 0.0618 (0.0511, 0.0749) 30.1 -log_k2 -4.51 0.08 1.77 0.011 (0.00941, 0.0129) 16.6 -g_qlogis -0.121 0.17 141 0.47 (0.388, 0.553) 0.373 -sigma_parent 3.72 3.72 -sigma_m1 1.44 1.44 - Shrink(SD)% -parent_0 69.2%> -log_k_m1 19.6%< -f_parent_qlogis -0.136%> -log_k1 6.71%< -log_k2 23.7%= -g_qlogis 19.5%< -sigma_parent -sigma_m1 +parent_0 100 0.685 0.682 100 (99, 102) 0.278 +log_k_m1 -5.35 0.0812 1.52 0.00477 (0.00407, 0.00559) 13.7 +f_parent_qlogis -0.091 0.096 106 0.477 (0.431, 0.524) 0.320 +log_k1 -2.76 0.0969 3.5 0.063 (0.0521, 0.0762) 29.9 +log_k2 -4.49 0.0658 1.47 0.0113 (0.00991, 0.0128) 18.6 +g_qlogis -0.167 0.142 85.3 0.458 (0.39, 0.528) 0.339 +sigma_low_parent 1.04 1.04 +rsd_high_parent 0.0531 0.0531 +sigma_low_m1 0.819 0.819 +rsd_high_m1 0.058 0.058 + Shrink(SD)% +parent_0 87.7%> +log_k_m1 44.8%> +f_parent_qlogis -0.375%> +log_k1 6.76%< +log_k2 10.4%< +g_qlogis 20.3%= +sigma_low_parent +rsd_high_parent +sigma_low_m1 +rsd_high_m1 diff --git a/tests/testthat/print_nlmixr_saem_biphasic_tc.txt b/tests/testthat/print_nlmixr_saem_biphasic_tc.txt deleted file mode 100644 index 2f940bfe..00000000 --- a/tests/testthat/print_nlmixr_saem_biphasic_tc.txt +++ /dev/null @@ -1,40 +0,0 @@ -Kinetic nonlinear mixed-effects model fit by saem using nlmixr -Structural model: -d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * parent -d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) - * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * parent - k_m1 * m1 - -Data: -507 observations of 2 variable(s) grouped in 15 datasets - -Likelihood: - - AIC BIC logLik - 2400 2468 -1184 - -Fitted parameters: - Est. SE %RSE Back-transformed(95%CI) BSV(CV% or SD) -parent_0 100 0.685 0.682 100 (99, 102) 0.278 -log_k_m1 -5.35 0.0812 1.52 0.00477 (0.00407, 0.00559) 13.7 -f_parent_qlogis -0.091 0.096 106 0.477 (0.431, 0.524) 0.320 -log_k1 -2.76 0.0969 3.5 0.063 (0.0521, 0.0762) 29.9 -log_k2 -4.49 0.0658 1.47 0.0113 (0.00991, 0.0128) 18.6 -g_qlogis -0.167 0.142 85.3 0.458 (0.39, 0.528) 0.339 -sigma_low_parent 1.04 1.04 -rsd_high_parent 0.0531 0.0531 -sigma_low_m1 0.819 0.819 -rsd_high_m1 0.058 0.058 - Shrink(SD)% -parent_0 87.7%> -log_k_m1 44.8%> -f_parent_qlogis -0.375%> -log_k1 6.76%< -log_k2 10.4%< -g_qlogis 20.3%= -sigma_low_parent -rsd_high_parent -sigma_low_m1 -rsd_high_m1 diff --git a/tests/testthat/setup_script.R b/tests/testthat/setup_script.R index 4b99ad67..ca0ca313 100644 --- a/tests/testthat/setup_script.R +++ b/tests/testthat/setup_script.R @@ -185,8 +185,7 @@ ds_biphasic <- lapply(ds_biphasic_mean, function(ds) { # Mixed model fits mmkin_sfo_1 <- mmkin("SFO", ds_sfo, quiet = TRUE, error_model = "tc", cores = n_cores) mmkin_dfop_1 <- mmkin("DFOP", ds_dfop, quiet = TRUE, cores = n_cores) -mmkin_biphasic <- mmkin(list("DFOP-SFO" = DFOP_SFO), ds_biphasic, quiet = TRUE, cores = n_cores) -mmkin_biphasic_tc <- mmkin(list("DFOP-SFO" = DFOP_SFO), ds_biphasic, quiet = TRUE, cores = n_cores, +mmkin_biphasic <- mmkin(list("DFOP-SFO" = DFOP_SFO), ds_biphasic, quiet = TRUE, cores = n_cores, error_model = "tc") mmkin_biphasic_mixed <- mixed(mmkin_biphasic) @@ -206,8 +205,6 @@ saem_biphasic_s <- saem(mmkin_biphasic, transformations = "saemix", quiet = TRUE # nlmixr saem tmp <- suppressMessages(capture.output(nlmixr_saem_biphasic <- nlmixr(mmkin_biphasic, est = "saem", control = nlmixr::saemControl(nBurn = 300, nEm = 100, nmc = 9, print = 0)))) -tmp <- suppressMessages(capture.output(nlmixr_saem_biphasic_tc <- nlmixr(mmkin_biphasic_tc, est = "saem", - control = nlmixr::saemControl(nBurn = 300, nEm = 100, nmc = 9, print = 0)))) # The FOCEI fit takes too long... #tmp <- capture_output(nlmixr_focei_biphasic <- nlmixr(mmkin_biphasic, est = "focei", # control = nlmixr::foceiControl(print = 0))) diff --git a/tests/testthat/summary_dfop_nlme_1.txt b/tests/testthat/summary_dfop_nlme_1.txt new file mode 100644 index 00000000..9da3fb1b --- /dev/null +++ b/tests/testthat/summary_dfop_nlme_1.txt @@ -0,0 +1,63 @@ +nlme version used for fitting: Dummy 0.0 for testing +mkin version used for pre-fitting: Dummy 0.0 for testing +R version used for fitting: Dummy R version for testing +Date of fit: Dummy date for testing +Date of summary: Dummy date for testing + +Equations: +d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * + time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) + * parent + +Data: +270 observations of 1 variable(s) grouped in 15 datasets + +Model predictions using solution type analytical + +Fitted in test time 0 s using 3 iterations + +Variance model: Constant variance + +Mean of starting values for individual parameters: +parent_0 log_k1 log_k2 g_qlogis + 100.06 -2.68 -4.16 0.01 + +Fixed degradation parameter values: +None + +Results: + + AIC BIC logLik + 1242 1274 -612 + +Optimised, transformed parameters with symmetric confidence intervals: + lower est. upper +parent_0 99.6 100.1 100.6 +log_k1 -2.9 -2.7 -2.4 +log_k2 -4.2 -4.1 -4.0 +g_qlogis -0.7 -0.5 -0.2 + +Correlation: + pr_0 lg_1 lg_2 +log_k1 0.2 +log_k2 0.1 0.2 +g_qlogis -0.2 -0.5 -0.4 + +Random effects: + Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) + Level: ds + Structure: Diagonal + parent_0 log_k1 log_k2 g_qlogis Residual +StdDev: 0.4 0.3 0.2 0.2 2 + + +Backtransformed parameters with asymmetric confidence intervals: + lower est. upper +parent_0 1e+02 1e+02 1e+02 +k1 6e-02 7e-02 9e-02 +k2 1e-02 2e-02 2e-02 +g 3e-01 4e-01 5e-01 + +Estimated disappearance times: + DT50 DT90 DT50back DT50_k1 DT50_k2 +parent 23 111 33 10 42 diff --git a/tests/testthat/summary_nlme_biphasic_s.txt b/tests/testthat/summary_nlme_biphasic_s.txt deleted file mode 100644 index 03ef49a6..00000000 --- a/tests/testthat/summary_nlme_biphasic_s.txt +++ /dev/null @@ -1,81 +0,0 @@ -nlme version used for fitting: Dummy 0.0 for testing -mkin version used for pre-fitting: Dummy 0.0 for testing -R version used for fitting: Dummy R version for testing -Date of fit: Dummy date for testing -Date of summary: Dummy date for testing - -Equations: -d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * parent -d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) - * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * parent - k_m1 * m1 - -Data: -507 observations of 2 variable(s) grouped in 15 datasets - -Model predictions using solution type analytical - -Fitted in test time 0 s using 4 iterations - -Variance model: Constant variance - -Mean of starting values for individual parameters: - parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 - 100.67 -5.38 -0.09 -2.74 -4.51 - g_qlogis - -0.18 - -Fixed degradation parameter values: - value type -m1_0 0 state - -Results: - - AIC BIC logLik - 2678 2733 -1326 - -Optimised, transformed parameters with symmetric confidence intervals: - lower est. upper -parent_0 99.8 100.7 101.62 -log_k_m1 -5.6 -5.4 -5.25 -f_parent_qlogis -0.3 -0.1 0.06 -log_k1 -3.0 -2.8 -2.57 -log_k2 -4.7 -4.5 -4.35 -g_qlogis -0.4 -0.1 0.17 - -Correlation: - pr_0 l__1 f_p_ lg_1 lg_2 -log_k_m1 -0.2 -f_parent_qlogis -0.1 0.4 -log_k1 0.2 0.0 0.0 -log_k2 0.1 0.2 0.0 0.4 -g_qlogis -0.1 -0.2 0.0 -0.5 -0.6 - -Random effects: - Formula: list(parent_0 ~ 1, log_k_m1 ~ 1, f_parent_qlogis ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) - Level: ds - Structure: Diagonal - parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 g_qlogis Residual -StdDev: 1 0.03 0.3 0.3 0.2 0.3 3 - - -Backtransformed parameters with asymmetric confidence intervals: - lower est. upper -parent_0 1e+02 1e+02 1e+02 -k_m1 4e-03 4e-03 5e-03 -f_parent_to_m1 4e-01 5e-01 5e-01 -k1 5e-02 6e-02 8e-02 -k2 9e-03 1e-02 1e-02 -g 4e-01 5e-01 5e-01 - -Resulting formation fractions: - ff -parent_m1 0.5 -parent_sink 0.5 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -parent 25 150 45 11 63 -m1 154 512 NA NA NA diff --git a/tests/testthat/summary_nlmixr_saem_biphasic.txt b/tests/testthat/summary_nlmixr_saem_biphasic.txt index f1cdc47b..144cbac7 100644 --- a/tests/testthat/summary_nlmixr_saem_biphasic.txt +++ b/tests/testthat/summary_nlmixr_saem_biphasic.txt @@ -19,17 +19,17 @@ Degradation model predictions using RxODE Fitted in test time 0 s -Variance model: Constant variance +Variance model: Two-component variance function Mean of starting values for individual parameters: parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 - 100.67 -5.38 -0.09 -2.74 -4.51 + 100.65 -5.38 -0.09 -2.74 -4.53 g_qlogis - -0.18 + -0.14 Mean of starting values for error model parameters: -sigma_parent sigma_m1 - 3 3 +sigma_low_parent rsd_high_parent sigma_low_m1 rsd_high_m1 + 0.79 0.05 0.79 0.05 Fixed degradation parameter values: None @@ -38,33 +38,33 @@ Results: Likelihood calculated by gauss3_1.6 AIC BIC logLik - 2510 2569 -1241 + 2400 2468 -1184 Optimised parameters: - est. lower upper -parent_0 100.49 99.6 101.37 -log_k_m1 -5.36 -5.5 -5.20 -f_parent_qlogis -0.09 -0.3 0.08 -log_k1 -2.78 -3.0 -2.59 -log_k2 -4.51 -4.7 -4.35 -g_qlogis -0.12 -0.5 0.21 + est. lower upper +parent_0 100.35 99.0 101.7 +log_k_m1 -5.35 -5.5 -5.2 +f_parent_qlogis -0.09 -0.3 0.1 +log_k1 -2.76 -3.0 -2.6 +log_k2 -4.49 -4.6 -4.4 +g_qlogis -0.17 -0.4 0.1 Correlation: pr_0 l__1 f_p_ lg_1 lg_2 -log_k_m1 -0.3 -f_parent_qlogis -0.2 0.3 -log_k1 0.1 0.1 0.0 -log_k2 0.0 0.3 0.1 0.4 -g_qlogis 0.0 -0.3 -0.1 -0.5 -0.7 +log_k_m1 -0.4 +f_parent_qlogis -0.4 0.4 +log_k1 0.2 -0.2 -0.1 +log_k2 0.0 0.1 0.0 0.3 +g_qlogis 0.1 -0.1 0.0 -0.4 -0.5 Random effects (omega): eta.parent_0 eta.log_k_m1 eta.f_parent_qlogis eta.log_k1 -eta.parent_0 0.2 0.00 0.00 0.00 -eta.log_k_m1 0.0 0.05 0.00 0.00 -eta.f_parent_qlogis 0.0 0.00 0.09 0.00 -eta.log_k1 0.0 0.00 0.00 0.09 -eta.log_k2 0.0 0.00 0.00 0.00 -eta.g_qlogis 0.0 0.00 0.00 0.00 +eta.parent_0 0.08 0.00 0.0 0.00 +eta.log_k_m1 0.00 0.02 0.0 0.00 +eta.f_parent_qlogis 0.00 0.00 0.1 0.00 +eta.log_k1 0.00 0.00 0.0 0.09 +eta.log_k2 0.00 0.00 0.0 0.00 +eta.g_qlogis 0.00 0.00 0.0 0.00 eta.log_k2 eta.g_qlogis eta.parent_0 0.00 0.0 eta.log_k_m1 0.00 0.0 @@ -74,17 +74,17 @@ eta.log_k2 0.03 0.0 eta.g_qlogis 0.00 0.1 Variance model: -sigma_parent sigma_m1 - 4 1 +sigma_low_parent rsd_high_parent sigma_low_m1 rsd_high_m1 + 1.04 0.05 0.82 0.06 Backtransformed parameters: est. lower upper parent_0 1e+02 1e+02 1e+02 k_m1 5e-03 4e-03 6e-03 f_parent_to_m1 5e-01 4e-01 5e-01 -k1 6e-02 5e-02 7e-02 -k2 1e-02 9e-03 1e-02 -g 5e-01 4e-01 6e-01 +k1 6e-02 5e-02 8e-02 +k2 1e-02 1e-02 1e-02 +g 5e-01 4e-01 5e-01 Resulting formation fractions: ff @@ -93,5 +93,5 @@ parent_sink 0.5 Estimated disappearance times: DT50 DT90 DT50back DT50_k1 DT50_k2 -parent 25 152 46 11 63 -m1 147 488 NA NA NA +parent 25 150 45 11 61 +m1 145 483 NA NA NA diff --git a/tests/testthat/summary_saem_biphasic_s.txt b/tests/testthat/summary_saem_biphasic_s.txt index 58bcddfb..a353d821 100644 --- a/tests/testthat/summary_saem_biphasic_s.txt +++ b/tests/testthat/summary_saem_biphasic_s.txt @@ -20,7 +20,7 @@ Model predictions using solution type analytical Fitted in test time 0 s Using 300, 100 iterations and 4 chains -Variance model: Constant variance +Variance model: Two-component variance function Mean of starting values for individual parameters: parent_0 k_m1 f_parent_to_m1 k1 k2 @@ -35,37 +35,38 @@ Results: Likelihood computed by importance sampling AIC BIC logLik - 2681 2690 -1328 + 2369 2379 -1170 Optimised parameters: est. lower upper parent_0 1e+02 1e+02 1e+02 k_m1 5e-03 4e-03 6e-03 f_parent_to_m1 5e-01 4e-01 5e-01 -k1 6e-02 5e-02 8e-02 -k2 1e-02 1e-02 1e-02 +k1 6e-02 5e-02 7e-02 +k2 1e-02 9e-03 1e-02 g 5e-01 4e-01 5e-01 Correlation: pr_0 k_m1 f___ k1 k2 -k_m1 -0.2 -f_parent_to_m1 -0.1 0.4 -k1 0.1 0.0 0.0 -k2 0.0 0.1 0.0 0.2 -g -0.1 -0.2 -0.1 -0.4 -0.5 +k_m1 -0.3 +f_parent_to_m1 -0.3 0.3 +k1 0.1 -0.1 -0.1 +k2 0.0 0.0 0.0 0.1 +g 0.1 -0.1 0.0 -0.3 -0.3 Random effects: - est. lower upper -SD.parent_0 1.203 0.3 2.1 -SD.k_m1 0.003 -8.3 8.3 -SD.f_parent_to_m1 0.336 0.2 0.5 -SD.k1 0.421 0.3 0.6 -SD.k2 0.280 0.2 0.4 -SD.g 0.010 -2.7 2.7 + est. lower upper +SD.parent_0 0.02 -89.53 89.6 +SD.k_m1 0.20 0.07 0.3 +SD.f_parent_to_m1 0.32 0.20 0.4 +SD.k1 0.38 0.23 0.5 +SD.k2 0.33 0.20 0.5 +SD.g 0.26 0.06 0.5 Variance model: est. lower upper -a.1 3 3 3 +a.1 0.90 0.76 1.03 +b.1 0.05 0.05 0.06 Resulting formation fractions: ff @@ -74,5 +75,5 @@ parent_sink 0.5 Estimated disappearance times: DT50 DT90 DT50back DT50_k1 DT50_k2 -parent 25 146 44 11 60 -m1 142 471 NA NA NA +parent 26 146 44 12 60 +m1 144 478 NA NA NA diff --git a/tests/testthat/test_dmta.R b/tests/testthat/test_dmta.R index 71e68f51..de4cbab7 100644 --- a/tests/testthat/test_dmta.R +++ b/tests/testthat/test_dmta.R @@ -91,7 +91,9 @@ test_that("Different backends get consistent results for DFOP tc, dimethenamid d backtransform_odeparms(ints_nlme$reStruct$ds[, "upper"], dmta_dfop$mkinmod))) # Variance function - skip_on_travis() # For some reason this fails on Travis + # Some of these tests on error model parameters fail on Travis and Winbuilder + skip_on_travis() + skip_on_cran() # saemix vs. nlme expect_true(all(ints_saemix[[3]][, "est."] > ints_nlme$varStruct[, "lower"])) diff --git a/tests/testthat/test_mixed.R b/tests/testthat/test_mixed.R index d30dcaa8..798dd01f 100644 --- a/tests/testthat/test_mixed.R +++ b/tests/testthat/test_mixed.R @@ -3,14 +3,14 @@ context("Nonlinear mixed-effects models") test_that("Print methods work", { expect_known_output(print(fits[, 2:3], digits = 2), "print_mmkin_parent.txt") expect_known_output(print(mmkin_biphasic_mixed, digits = 2), "print_mmkin_biphasic_mixed.txt") - expect_known_output(print(nlme_biphasic, digits = 1), "print_nlme_biphasic.txt") + expect_known_output(print(dfop_nlme_1, digits = 1), "print_dfop_nlme_1.txt") expect_known_output(print(sfo_saem_1, digits = 1), "print_sfo_saem_1.txt") }) test_that("nlme results are reproducible to some degree", { - test_summary <- summary(nlme_biphasic) + test_summary <- summary(dfop_nlme_1) test_summary$nlmeversion <- "Dummy 0.0 for testing" test_summary$mkinversion <- "Dummy 0.0 for testing" test_summary$Rversion <- "Dummy R version for testing" @@ -18,16 +18,18 @@ test_that("nlme results are reproducible to some degree", { test_summary$date.summary <- "Dummy date for testing" test_summary$time <- c(elapsed = "test time 0") - expect_known_output(print(test_summary, digits = 1), "summary_nlme_biphasic_s.txt") + expect_known_output(print(test_summary, digits = 1), "summary_dfop_nlme_1.txt") - # k1 just fails the first test (lower bound of the ci), so we need to exclude it - dfop_no_k1 <- c("parent_0", "k_m1", "f_parent_to_m1", "k2", "g") - dfop_sfo_pop_no_k1 <- as.numeric(dfop_sfo_pop[dfop_no_k1]) - dfop_sfo_pop <- as.numeric(dfop_sfo_pop) + # The biphasic example data illustrate that DFOP parameters are difficult to + # quantify with the usual design + # k1 and k2 just fail the first test (lower bound of the ci), so we need to exclude it + dfop_no_k1_k2 <- c("parent_0", "k_m1", "f_parent_to_m1", "g") + dfop_sfo_pop_no_k1_k2 <- as.numeric(dfop_sfo_pop[dfop_no_k1_k2]) + dfop_sfo_pop <- as.numeric(dfop_sfo_pop) # to remove names ci_dfop_sfo_n <- summary(nlme_biphasic)$confint_back - expect_true(all(ci_dfop_sfo_n[dfop_no_k1, "lower"] < dfop_sfo_pop_no_k1)) + expect_true(all(ci_dfop_sfo_n[dfop_no_k1_k2, "lower"] < dfop_sfo_pop_no_k1_k2)) expect_true(all(ci_dfop_sfo_n[, "upper"] > dfop_sfo_pop)) }) @@ -49,14 +51,13 @@ test_that("saemix results are reproducible for biphasic fits", { no_k1_k2 <- c(1, 2, 3, 6) ci_dfop_sfo_s_s <- summary(saem_biphasic_s)$confint_back - # k1 and k2 are overestimated - expect_true(all(ci_dfop_sfo_s_s[no_k1_k2, "lower"] < dfop_sfo_pop[no_k1_k2])) + expect_true(all(ci_dfop_sfo_s_s[, "lower"] < dfop_sfo_pop)) expect_true(all(ci_dfop_sfo_s_s[, "upper"] > dfop_sfo_pop)) - # k1 and k2 are not fitted well + # k2 is not fitted well ci_dfop_sfo_s_m <- summary(saem_biphasic_m)$confint_back expect_true(all(ci_dfop_sfo_s_m[no_k2, "lower"] < dfop_sfo_pop[no_k2])) - expect_true(all(ci_dfop_sfo_s_m[no_k1, "upper"] > dfop_sfo_pop[no_k1])) + expect_true(all(ci_dfop_sfo_s_m[, "upper"] > dfop_sfo_pop)) # I tried to only do few iterations in routine tests as this is so slow # but then deSolve fails at some point (presumably at the switch between @@ -84,7 +85,6 @@ test_that("nlmixr results are reproducible for biphasic fits", { test_summary$time <- c(elapsed = "test time 0") expect_known_output(print(nlmixr_saem_biphasic, digits = 1), "print_nlmixr_saem_biphasic.txt") - expect_known_output(print(nlmixr_saem_biphasic_tc, digits = 1), "print_nlmixr_saem_biphasic_tc.txt") expect_known_output(print(test_summary, digits = 1), "summary_nlmixr_saem_biphasic.txt") }) diff --git a/tests/testthat/test_mkinds.R b/tests/testthat/test_mkinds.R index c10a3f5b..8826f548 100644 --- a/tests/testthat/test_mkinds.R +++ b/tests/testthat/test_mkinds.R @@ -9,5 +9,6 @@ test_that("An mkindsg object can be created and printed", { testdata_group <- mkindsg$new("Experimental X", experimental_data_for_UBA_2019[6:10]) expect_known_output(print(testdata_group), "experimental_data_for_UBA_2019_mkindsg.txt") + skip_on_cran() # we get uneven spacing on winbuilder for some reason (2022-03-02, R 4.1.2) expect_known_output(print(dimethenamid_2018), "dimethenamid_2018.txt") }) diff --git a/vignettes/FOCUS_D.html b/vignettes/FOCUS_D.html index 0bec44c5..1b9d2e23 100644 --- a/vignettes/FOCUS_D.html +++ b/vignettes/FOCUS_D.html @@ -360,7 +360,7 @@ pre code { <h1 class="title toc-ignore">Example evaluation of FOCUS Example Dataset D</h1> <h4 class="author">Johannes Ranke</h4> -<h4 class="date">Last change 31 January 2019 (rebuilt 2022-02-08)</h4> +<h4 class="date">Last change 31 January 2019 (rebuilt 2022-03-02)</h4> </div> @@ -436,8 +436,8 @@ print(FOCUS_2006_D)</code></pre> <pre class="r"><code>summary(fit)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:25 2022 -## Date of summary: Tue Feb 8 17:20:26 2022 +## Date of fit: Wed Mar 2 16:28:06 2022 +## Date of summary: Wed Mar 2 16:28:07 2022 ## ## Equations: ## d_parent/dt = - k_parent * parent diff --git a/vignettes/FOCUS_L.html b/vignettes/FOCUS_L.html index 4a66985e..2934bc99 100644 --- a/vignettes/FOCUS_L.html +++ b/vignettes/FOCUS_L.html @@ -1513,7 +1513,7 @@ div.tocify { <h1 class="title toc-ignore">Example evaluation of FOCUS Laboratory Data L1 to L3</h1> <h4 class="author">Johannes Ranke</h4> -<h4 class="date">Last change 17 November 2016 (rebuilt 2022-02-08)</h4> +<h4 class="date">Last change 17 November 2016 (rebuilt 2022-03-02)</h4> </div> @@ -1534,8 +1534,8 @@ FOCUS_2006_L1_mkin <- mkin_wide_to_long(FOCUS_2006_L1)</code></pre> summary(m.L1.SFO)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:28 2022 -## Date of summary: Tue Feb 8 17:20:28 2022 +## Date of fit: Wed Mar 2 16:28:09 2022 +## Date of summary: Wed Mar 2 16:28:09 2022 ## ## Equations: ## d_parent/dt = - k_parent * parent @@ -1635,15 +1635,15 @@ summary(m.L1.SFO)</code></pre> ## doubtful</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:28 2022 -## Date of summary: Tue Feb 8 17:20:28 2022 +## Date of fit: Wed Mar 2 16:28:09 2022 +## Date of summary: Wed Mar 2 16:28:09 2022 ## ## Equations: ## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent ## ## Model predictions using solution type analytical ## -## Fitted using 369 model solutions performed in 0.081 s +## Fitted using 369 model solutions performed in 0.082 s ## ## Error model: Constant variance ## @@ -1740,8 +1740,8 @@ plot(m.L2.FOMC, show_residuals = TRUE, <pre class="r"><code>summary(m.L2.FOMC, data = FALSE)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:28 2022 -## Date of summary: Tue Feb 8 17:20:28 2022 +## Date of fit: Wed Mar 2 16:28:10 2022 +## Date of summary: Wed Mar 2 16:28:10 2022 ## ## Equations: ## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent @@ -1818,8 +1818,8 @@ plot(m.L2.DFOP, show_residuals = TRUE, show_errmin = TRUE, <pre class="r"><code>summary(m.L2.DFOP, data = FALSE)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:29 2022 -## Date of summary: Tue Feb 8 17:20:29 2022 +## Date of fit: Wed Mar 2 16:28:10 2022 +## Date of summary: Wed Mar 2 16:28:10 2022 ## ## Equations: ## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * @@ -1828,7 +1828,7 @@ plot(m.L2.DFOP, show_residuals = TRUE, show_errmin = TRUE, ## ## Model predictions using solution type analytical ## -## Fitted using 581 model solutions performed in 0.136 s +## Fitted using 581 model solutions performed in 0.137 s ## ## Error model: Constant variance ## @@ -1918,8 +1918,8 @@ plot(mm.L3)</code></pre> <pre class="r"><code>summary(mm.L3[["DFOP", 1]])</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:29 2022 -## Date of summary: Tue Feb 8 17:20:29 2022 +## Date of fit: Wed Mar 2 16:28:10 2022 +## Date of summary: Wed Mar 2 16:28:10 2022 ## ## Equations: ## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * @@ -1928,7 +1928,7 @@ plot(mm.L3)</code></pre> ## ## Model predictions using solution type analytical ## -## Fitted using 376 model solutions performed in 0.078 s +## Fitted using 376 model solutions performed in 0.08 s ## ## Error model: Constant variance ## @@ -2026,8 +2026,8 @@ plot(mm.L4)</code></pre> <pre class="r"><code>summary(mm.L4[["SFO", 1]], data = FALSE)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:29 2022 -## Date of summary: Tue Feb 8 17:20:30 2022 +## Date of fit: Wed Mar 2 16:28:11 2022 +## Date of summary: Wed Mar 2 16:28:11 2022 ## ## Equations: ## d_parent/dt = - k_parent * parent @@ -2090,8 +2090,8 @@ plot(mm.L4)</code></pre> <pre class="r"><code>summary(mm.L4[["FOMC", 1]], data = FALSE)</code></pre> <pre><code>## mkin version used for fitting: 1.1.0 ## R version used for fitting: 4.1.2 -## Date of fit: Tue Feb 8 17:20:30 2022 -## Date of summary: Tue Feb 8 17:20:30 2022 +## Date of fit: Wed Mar 2 16:28:11 2022 +## Date of summary: Wed Mar 2 16:28:11 2022 ## ## Equations: ## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent diff --git a/vignettes/mkin.html b/vignettes/mkin.html index 8a1a7641..1f35e9bd 100644 --- a/vignettes/mkin.html +++ b/vignettes/mkin.html @@ -1591,7 +1591,7 @@ div.tocify { <h1 class="title toc-ignore">Introduction to mkin</h1> <h4 class="author">Johannes Ranke</h4> -<h4 class="date">Last change 15 February 2021 (rebuilt 2022-02-08)</h4> +<h4 class="date">Last change 15 February 2021 (rebuilt 2022-03-02)</h4> </div> @@ -1698,10 +1698,10 @@ plot_sep(f_SFO_SFO_SFO, lpos = c("topright", "bottomright", <p>Ranke, J. 2021. <em>‘mkin‘: Kinetic Evaluation of Chemical Degradation Data</em>. <a href="https://CRAN.R-project.org/package=mkin">https://CRAN.R-project.org/package=mkin</a>.</p> </div> <div id="ref-ranke2012"> -<p>Ranke, J., and R. Lehmann. 2012. “Parameter Reliability in Kinetic Evaluation of Environmental Metabolism Data - Assessment and the Influence of Model Specification.” In <em>SETAC World 20-24 May</em>. Berlin.</p> +<p>Ranke, J., and R. Lehmann. 2012. “Parameter Reliability in Kinetic Evaluation of Environmental Metabolism Data - Assessment and the Influence of Model Specification.” In <em>SETAC World 20-24 May</em>. Berlin. <a href="https://jrwb.de/posters/Poster_SETAC_2012_Kinetic_parameter_uncertainty_model_parameterization_Lehmann_Ranke.pdf">https://jrwb.de/posters/Poster_SETAC_2012_Kinetic_parameter_uncertainty_model_parameterization_Lehmann_Ranke.pdf</a>.</p> </div> <div id="ref-ranke2015"> -<p>———. 2015. “To T-Test or Not to T-Test, That Is the Question.” In <em>XV Symposium on Pesticide Chemistry 2-4 September 2015</em>. Piacenza. <a href="http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf">http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf</a>.</p> +<p>———. 2015. “To T-Test or Not to T-Test, That Is the Question.” In <em>XV Symposium on Pesticide Chemistry 2-4 September 2015</em>. Piacenza. <a href="https://jrwb.de/posters/piacenza_2015.pdf">https://jrwb.de/posters/piacenza_2015.pdf</a>.</p> </div> <div id="ref-ranke2019"> <p>Ranke, Johannes, and Stefan Meinecke. 2019. “Error Models for the Kinetic Evaluation of Chemical Degradation Data.” <em>Environments</em> 6 (12). <a href="https://doi.org/10.3390/environments6120124">https://doi.org/10.3390/environments6120124</a>.</p> diff --git a/vignettes/references.bib b/vignettes/references.bib index 2ee2ef2b..69845b1b 100644 --- a/vignettes/references.bib +++ b/vignettes/references.bib @@ -81,7 +81,8 @@ author = {J. Ranke and R. Lehmann}, booktitle = {SETAC World 20-24 May}, year = {2012}, - address = {Berlin} + address = {Berlin}, + url = {https://jrwb.de/posters/Poster_SETAC_2012_Kinetic_parameter_uncertainty_model_parameterization_Lehmann_Ranke.pdf} } @Inproceedings{ ranke2015, title = {To t-test or not to t-test, that is the question}, @@ -89,7 +90,7 @@ booktitle = {XV Symposium on Pesticide Chemistry 2-4 September 2015}, year = {2015}, address = {Piacenza}, - url = {http://chem.uft.uni-bremen.de/ranke/posters/piacenza_2015.pdf} + url = {https://jrwb.de/posters/piacenza_2015.pdf} } @Techreport{ranke2014, title = {{Prüfung und Validierung von Modellierungssoftware als Alternative zu diff --git a/vignettes/twa.html b/vignettes/twa.html index dc8f685f..fd0fe2d6 100644 --- a/vignettes/twa.html +++ b/vignettes/twa.html @@ -253,7 +253,7 @@ code > span.er { color: #a61717; background-color: #e3d2d2; } <h1 class="title toc-ignore">Calculation of time weighted average concentrations with mkin</h1> <h4 class="author">Johannes Ranke</h4> -<h4 class="date">Last change 18 September 2019 (rebuilt 2022-02-08)</h4> +<h4 class="date">Last change 18 September 2019 (rebuilt 2022-03-02)</h4> diff --git a/vignettes/web_only/mkin_benchmarks.rda b/vignettes/web_only/mkin_benchmarks.rda Binary files differindex fe4ab843..99b216d9 100644 --- a/vignettes/web_only/mkin_benchmarks.rda +++ b/vignettes/web_only/mkin_benchmarks.rda |
