diff options
| -rw-r--r-- | NEWS.md | 2 | ||||
| -rw-r--r-- | R/multistart.R | 24 |
2 files changed, 26 insertions, 0 deletions
@@ -1,5 +1,7 @@ # mkin 1.1.2 +- 'R/multistart.R': New method for testing multiple start parameters for hierarchical model fits. + - 'R/mhmkin.R': New method for performing multiple hierarchical mkin fits in one function call, optionally in parallel. - 'R/saem.R': Implement and test saemix transformations for FOMC and HS. Also, error out if saemix transformations are requested but not supported. diff --git a/R/multistart.R b/R/multistart.R new file mode 100644 index 00000000..db482cc4 --- /dev/null +++ b/R/multistart.R @@ -0,0 +1,24 @@ +#' Perform a hierarchical model fit with multiple starting values +#' +#' The purpose of this method is to check if a certain algorithm for fitting +#' nonlinear hierarchical models (also known as nonlinear mixed-effects models) +#' will reliably yield results that are sufficiently similar to each other, if +#' started with a certain range of reasonable starting parameters. It is +#' inspired by the article on practical identifiabiliy in the frame of nonlinear +#' mixed-effects models by Duchesne et al (2021). +#' +#' @references Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical +#' identifiability in the frame of nonlinear mixed effects models: the example +#' of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. +#' doi: 10.1186/s12859-021-04373-4. +#' @export +multistart <- function(object, n = 50, ...) +{ + UseMethod("multistart", object) +} + +#' @rdname multistart +#' @export +multistart.saem.mmkin <- function(object, n = 50, ...) { + +} |