diff options
| -rw-r--r-- | R/saem.R | 14 |
1 files changed, 10 insertions, 4 deletions
@@ -22,6 +22,8 @@ utils::globalVariables(c("predicted", "std")) #' are done in 'saemix' for the supported cases. Currently this is only #' supported in cases where the initial concentration of the parent is not fixed, #' SFO or DFOP is used for the parent and there is either no metabolite or one. +#' @param degparms_start Parameter values given as a named numeric vector will +#' be used to override the starting values obtained from the 'mmkin' object. #' @param solution_type Possibility to specify the solution type in case the #' automatic choice is not desired #' @param quiet Should we suppress the messages saemix prints at the beginning @@ -103,6 +105,7 @@ saem <- function(object, ...) UseMethod("saem") #' @export saem.mmkin <- function(object, transformations = c("mkin", "saemix"), + degparms_start = numeric(), solution_type = "auto", control = list(displayProgress = FALSE, print = FALSE, save = FALSE, save.graphs = FALSE), @@ -110,7 +113,8 @@ saem.mmkin <- function(object, { transformations <- match.arg(transformations) m_saemix <- saemix_model(object, verbose = verbose, - solution_type = solution_type, transformations = transformations, ...) + degparms_start = degparms_start, solution_type = solution_type, + transformations = transformations, ...) d_saemix <- saemix_data(object, verbose = verbose) if (suppressPlot) { @@ -210,7 +214,7 @@ print.saem.mmkin <- function(x, digits = max(3, getOption("digits") - 3), ...) { #' @return An [saemix::SaemixModel] object. #' @export saemix_model <- function(object, solution_type = "auto", transformations = c("mkin", "saemix"), - verbose = FALSE, ...) + degparms_start = numeric(), verbose = FALSE, ...) { if (nrow(object) > 1) stop("Only row objects allowed") @@ -477,8 +481,10 @@ saemix_model <- function(object, solution_type = "auto", transformations = c("mk b = mean(sapply(object, function(x) x$errparms[2]))), obs = c(a = mean(sapply(object, function(x) x$errparms)), b = 1)) - psi0_matrix <- matrix(degparms_optim, nrow = 1) - colnames(psi0_matrix) <- names(degparms_optim) + degparms_psi0 <- degparms_optim + degparms_psi0[names(degparms_start)] <- degparms_start + psi0_matrix <- matrix(degparms_psi0, nrow = 1) + colnames(psi0_matrix) <- names(degparms_psi0) res <- saemix::saemixModel(model_function, psi0 = psi0_matrix, |