diff options
Diffstat (limited to 'R/saem.R')
| -rw-r--r-- | R/saem.R | 31 |
1 files changed, 26 insertions, 5 deletions
@@ -24,8 +24,16 @@ utils::globalVariables(c("predicted", "std")) #' SFO or DFOP is used for the parent and there is either no metabolite or one. #' @param degparms_start Parameter values given as a named numeric vector will #' be used to override the starting values obtained from the 'mmkin' object. +#' @param test_log_parms If TRUE, an attempt is made to use more robust starting +#' values for population parameters fitted as log parameters in mkin (like +#' rate constants) by only considering rate constants that pass the t-test +#' when calculating mean degradation parameters using [mean_degparms]. +#' @param conf.level Possibility to adjust the required confidence level +#' for parameter that are tested if requested by 'test_log_parms'. #' @param solution_type Possibility to specify the solution type in case the #' automatic choice is not desired +#' @param fail_with_errors Should a failure to compute standard errors +#' from the inverse of the Fisher Information Matrix be a failure? #' @param quiet Should we suppress the messages saemix prints at the beginning #' and the end of the optimisation process? #' @param control Passed to [saemix::saemix] @@ -51,7 +59,7 @@ utils::globalVariables(c("predicted", "std")) #' # The returned saem.mmkin object contains an SaemixObject, therefore we can use #' # functions from saemix #' library(saemix) -#' compare.saemix(list(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so)) +#' compare.saemix(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so) #' plot(f_saem_fomc$so, plot.type = "convergence") #' plot(f_saem_fomc$so, plot.type = "individual.fit") #' plot(f_saem_fomc$so, plot.type = "npde") @@ -59,7 +67,7 @@ utils::globalVariables(c("predicted", "std")) #' #' f_mmkin_parent_tc <- update(f_mmkin_parent, error_model = "tc") #' f_saem_fomc_tc <- saem(f_mmkin_parent_tc["FOMC", ]) -#' compare.saemix(list(f_saem_fomc$so, f_saem_fomc_tc$so)) +#' compare.saemix(f_saem_fomc$so, f_saem_fomc_tc$so) #' #' sfo_sfo <- mkinmod(parent = mkinsub("SFO", "A1"), #' A1 = mkinsub("SFO")) @@ -104,19 +112,32 @@ saem <- function(object, ...) UseMethod("saem") saem.mmkin <- function(object, transformations = c("mkin", "saemix"), degparms_start = numeric(), + test_log_parms = FALSE, + conf.level = 0.6, solution_type = "auto", control = list(displayProgress = FALSE, print = FALSE, save = FALSE, save.graphs = FALSE), + fail_with_errors = TRUE, verbose = FALSE, quiet = FALSE, ...) { transformations <- match.arg(transformations) m_saemix <- saemix_model(object, verbose = verbose, - degparms_start = degparms_start, solution_type = solution_type, + degparms_start = degparms_start, + test_log_parms = test_log_parms, conf.level = conf.level, + solution_type = solution_type, transformations = transformations, ...) d_saemix <- saemix_data(object, verbose = verbose) fit_time <- system.time({ utils::capture.output(f_saemix <- saemix::saemix(m_saemix, d_saemix, control), split = !quiet) + FIM_failed <- NULL + if (any(is.na(f_saemix@results@se.fixed))) FIM_failed <- c(FIM_failed, "fixed effects") + if (any(is.na(c(f_saemix@results@se.omega, f_saemix@results@se.respar)))) { + FIM_failed <- c(FIM_failed, "random effects and residual error parameters") + } + if (!is.null(FIM_failed) & fail_with_errors) { + stop("Could not invert FIM for ", paste(FIM_failed, collapse = " and ")) + } }) transparms_optim <- f_saemix@results@fixed.effects @@ -203,13 +224,13 @@ print.saem.mmkin <- function(x, digits = max(3, getOption("digits") - 3), ...) { #' @return An [saemix::SaemixModel] object. #' @export saemix_model <- function(object, solution_type = "auto", transformations = c("mkin", "saemix"), - degparms_start = numeric(), verbose = FALSE, ...) + degparms_start = numeric(), test_log_parms = FALSE, verbose = FALSE, ...) { if (nrow(object) > 1) stop("Only row objects allowed") mkin_model <- object[[1]]$mkinmod - degparms_optim <- mean_degparms(object) + degparms_optim <- mean_degparms(object, test_log_parms = test_log_parms) if (transformations == "saemix") { degparms_optim <- backtransform_odeparms(degparms_optim, object[[1]]$mkinmod, |