diff options
Diffstat (limited to 'R')
| -rw-r--r-- | R/endpoints.R | 21 |
1 files changed, 14 insertions, 7 deletions
diff --git a/R/endpoints.R b/R/endpoints.R index a930acb7..95966cf7 100644 --- a/R/endpoints.R +++ b/R/endpoints.R @@ -84,8 +84,11 @@ endpoints <- function(fit) { DT50_k2 = log(2)/k2
DT90_k1 = log(10)/k1
DT90_k2 = log(10)/k2
- DT50 <- try(exp(optimize(f, c(log(DT50_k1), log(DT50_k2)), x=50)$minimum))
- DT90 <- try(exp(optimize(f, c(log(DT90_k1), log(DT90_k2)), x=90)$minimum))
+
+ DT50 <- try(exp(optimize(f, c(log(DT50_k1), log(DT50_k2)), x=50)$minimum),
+ silent = TRUE)
+ DT90 <- try(exp(optimize(f, c(log(DT90_k1), log(DT90_k2)), x=90)$minimum),
+ silent = TRUE)
if (inherits(DT50, "try-error")) DT50 = NA
if (inherits(DT90, "try-error")) DT90 = NA
@@ -127,18 +130,22 @@ endpoints <- function(fit) { DT90_b1 = log(10)/b1
DT90_b2 = log(10)/b2
-
SFORB_fraction = function(t) {
((k_12 + k_21 - b1)/(b2 - b1)) * exp(-b1 * t) +
((k_12 + k_21 - b2)/(b1 - b2)) * exp(-b2 * t)
}
+
f_50 <- function(log_t) (SFORB_fraction(exp(log_t)) - 0.5)^2
- DT50 <- try(exp(optimize(f_50, c(log(DT50_b1), log(DT50_b2)))$minimum))
+ log_DT50 <- try(optimize(f_50, c(log(DT50_b1), log(DT50_b2)))$minimum,
+ silent = TRUE)
f_90 <- function(log_t) (SFORB_fraction(exp(log_t)) - 0.1)^2
- DT90 <- try(exp(optimize(f_90, c(log(DT90_b1), log(DT90_b2)))$minimum))
+ log_DT90 <- try(optimize(f_90, c(log(DT90_b1), log(DT90_b2)))$minimum,
+ silent = TRUE)
- if (inherits(DT50, "try-error")) DT50 = NA
- if (inherits(DT90, "try-error")) DT90 = NA
+ DT50 = if (inherits(log_DT50, "try-error")) NA
+ else exp(log_DT50)
+ DT90 = if (inherits(log_DT90, "try-error")) NA
+ else exp(log_DT90)
for (k_out_name in k_out_names)
{
|