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@@ -96,9 +96,16 @@ version is found in the ['dev' subdirectory](https://pkgdown.jrwb.de/mkin/dev/). interpretation of the model parameters. * Nonlinear mixed-effects models can be created from fits of the same degradation model to different datasets for the same compound by using the - [nlme.mmkin](https://pkgdown.jrwb.de/mkin/reference/nlme.mmkin.html) method. - Note that the convergence of the nlme fits depends on the quality of the data. - Convergence is better for simple models and data for many groups (e.g. soils). + [nlme.mmkin](https://pkgdown.jrwb.de/mkin/reference/nlme.mmkin.html) and + [saem.mmkin](https://pkgdown.jrwb.de/mkin/reference/saem.mmkin.html) and + methods. Note that the convergence of the nlme fits depends on the quality of + the data. Convergence is better for simple models and data for many groups + (e.g. soils). The saem method uses the `saemix` package as a backend. Analytical + solutions suitable for use with this package have been implemented for parent + only models and the most important models including one metabolite (SFO-SFO + and DFOP-SFO). Fitting other models with `saem.mmkin`, while it makes use + of the compiled ODE models that mkin provides, has longer run times (at least + six minutes on my system). ### Performance |