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<title>Testing hierarchical pathway kinetics with residue data on cyantraniliprole • mkin</title>
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- <h1 data-toc-skip>Testing hierarchical pathway kinetics with
-residue data on cyantraniliprole</h1>
+
+<div class="row">
+ <main id="main" class="col-md-9"><div class="page-header">
+ <img src="" class="logo" alt=""><h1>Testing hierarchical pathway kinetics with residue data on cyantraniliprole</h1>
<h4 data-toc-skip class="author">Johannes
Ranke</h4>
<h4 data-toc-skip class="date">Last change on 20 April 2023,
-last compiled on 30 October 2023</h4>
+last compiled on 16 November 2023</h4>
<small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_cyan_pathway.rmd" class="external-link"><code>vignettes/prebuilt/2022_cyan_pathway.rmd</code></a></small>
- <div class="hidden name"><code>2022_cyan_pathway.rmd</code></div>
-
+ <div class="d-none name"><code>2022_cyan_pathway.rmd</code></div>
</div>
@@ -2209,9 +2168,9 @@ Hierarchical SFO path 1 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:03:13 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:27:41 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - k_cyan * cyan
@@ -2224,7 +2183,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1273.632 s
+Fitted in 421.347 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -2337,9 +2296,9 @@ Hierarchical SFO path 1 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 09:58:51 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:27:55 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - k_cyan * cyan
@@ -2352,7 +2311,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1011.299 s
+Fitted in 435.122 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -2467,9 +2426,9 @@ Hierarchical FOMC path 1 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:04:48 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:28:33 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -2484,7 +2443,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1368.338 s
+Fitted in 473.357 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -2612,9 +2571,9 @@ Hierarchical FOMC path 1 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:00:40 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:28:46 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -2629,7 +2588,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1120.168 s
+Fitted in 486.031 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -2750,9 +2709,9 @@ Hierarchical DFOP path 1 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:02:52 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:29:15 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -2771,7 +2730,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1252.502 s
+Fitted in 514.477 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -2896,9 +2855,9 @@ Hierarchical DFOP path 1 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:12:10 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:31:58 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -2917,7 +2876,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1809.832 s
+Fitted in 677.928 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -3042,9 +3001,9 @@ Hierarchical SFORB path 1 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:02:30 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:29:33 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -3062,7 +3021,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1230.946 s
+Fitted in 532.937 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -3207,9 +3166,9 @@ Hierarchical SFORB path 1 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:09:13 2023
-Date of summary: Mon Oct 30 11:18:26 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:31:58 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -3227,7 +3186,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1633.433 s
+Fitted in 677.936 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -3372,14 +3331,142 @@ Hierarchical HS path 1 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:02:52 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:29:18 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
-d_cyan/dt = - ifelse(time
-<p></p></code>
-</pre>
+d_cyan/dt = - ifelse(time &lt;= tb, k1, k2) * cyan
+d_JCZ38/dt = + f_cyan_to_JCZ38 * ifelse(time &lt;= tb, k1, k2) * cyan -
+ k_JCZ38 * JCZ38
+d_J9Z38/dt = + f_cyan_to_J9Z38 * ifelse(time &lt;= tb, k1, k2) * cyan -
+ k_J9Z38 * J9Z38
+d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76
+
+Data:
+433 observations of 4 variable(s) grouped in 5 datasets
+
+Model predictions using solution type deSolve
+
+Fitted in 518.128 s
+Using 300, 100 iterations and 10 chains
+
+Variance model: Constant variance
+
+Starting values for degradation parameters:
+ cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1
+ 102.8845 -3.4495 -4.9355 -5.6040 0.6468
+ f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb
+ 1.2396 9.7220 -2.9079 -4.1810 1.7813
+
+Fixed degradation parameter values:
+None
+
+Starting values for random effects (square root of initial entries in omega):
+ cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1
+cyan_0 5.406 0.00 0.00 0.000 0.0000
+log_k_JCZ38 0.000 2.33 0.00 0.000 0.0000
+log_k_J9Z38 0.000 0.00 1.59 0.000 0.0000
+log_k_JSE76 0.000 0.00 0.00 1.013 0.0000
+f_cyan_ilr_1 0.000 0.00 0.00 0.000 0.6367
+f_cyan_ilr_2 0.000 0.00 0.00 0.000 0.0000
+f_JCZ38_qlogis 0.000 0.00 0.00 0.000 0.0000
+log_k1 0.000 0.00 0.00 0.000 0.0000
+log_k2 0.000 0.00 0.00 0.000 0.0000
+log_tb 0.000 0.00 0.00 0.000 0.0000
+ f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb
+cyan_0 0.000 0.00 0.0000 0.0000 0.0000
+log_k_JCZ38 0.000 0.00 0.0000 0.0000 0.0000
+log_k_J9Z38 0.000 0.00 0.0000 0.0000 0.0000
+log_k_JSE76 0.000 0.00 0.0000 0.0000 0.0000
+f_cyan_ilr_1 0.000 0.00 0.0000 0.0000 0.0000
+f_cyan_ilr_2 2.038 0.00 0.0000 0.0000 0.0000
+f_JCZ38_qlogis 0.000 10.33 0.0000 0.0000 0.0000
+log_k1 0.000 0.00 0.7006 0.0000 0.0000
+log_k2 0.000 0.00 0.0000 0.8928 0.0000
+log_tb 0.000 0.00 0.0000 0.0000 0.6773
+
+Starting values for error model parameters:
+a.1
+ 1
+
+Results:
+
+Likelihood computed by importance sampling
+ AIC BIC logLik
+ 2427 2419 -1194
+
+Optimised parameters:
+ est. lower upper
+cyan_0 101.9660 1.005e+02 1.035e+02
+log_k_JCZ38 -3.4698 -4.716e+00 -2.224e+00
+log_k_J9Z38 -5.0947 -5.740e+00 -4.450e+00
+log_k_JSE76 -5.5977 -6.321e+00 -4.875e+00
+f_cyan_ilr_1 0.6595 3.734e-01 9.456e-01
+f_cyan_ilr_2 0.5905 1.664e-01 1.015e+00
+f_JCZ38_qlogis 25.8627 -4.224e+05 4.225e+05
+log_k1 -3.0884 -3.453e+00 -2.723e+00
+log_k2 -4.3877 -4.778e+00 -3.998e+00
+log_tb 2.3057 1.715e+00 2.896e+00
+a.1 3.3228 NA NA
+SD.log_k_JCZ38 1.4071 NA NA
+SD.log_k_J9Z38 0.5774 NA NA
+SD.log_k_JSE76 0.6214 NA NA
+SD.f_cyan_ilr_1 0.3058 NA NA
+SD.f_cyan_ilr_2 0.3470 NA NA
+SD.f_JCZ38_qlogis 0.0644 NA NA
+SD.log_k1 0.3994 NA NA
+SD.log_k2 0.4373 NA NA
+SD.log_tb 0.6419 NA NA
+
+Correlation is not available
+
+Random effects:
+ est. lower upper
+SD.log_k_JCZ38 1.4071 NA NA
+SD.log_k_J9Z38 0.5774 NA NA
+SD.log_k_JSE76 0.6214 NA NA
+SD.f_cyan_ilr_1 0.3058 NA NA
+SD.f_cyan_ilr_2 0.3470 NA NA
+SD.f_JCZ38_qlogis 0.0644 NA NA
+SD.log_k1 0.3994 NA NA
+SD.log_k2 0.4373 NA NA
+SD.log_tb 0.6419 NA NA
+
+Variance model:
+ est. lower upper
+a.1 3.323 NA NA
+
+Backtransformed parameters:
+ est. lower upper
+cyan_0 1.020e+02 1.005e+02 1.035e+02
+k_JCZ38 3.112e-02 8.951e-03 1.082e-01
+k_J9Z38 6.129e-03 3.216e-03 1.168e-02
+k_JSE76 3.706e-03 1.798e-03 7.639e-03
+f_cyan_to_JCZ38 5.890e-01 NA NA
+f_cyan_to_J9Z38 2.318e-01 NA NA
+f_JCZ38_to_JSE76 1.000e+00 0.000e+00 1.000e+00
+k1 4.558e-02 3.164e-02 6.565e-02
+k2 1.243e-02 8.417e-03 1.835e-02
+tb 1.003e+01 5.557e+00 1.811e+01
+
+Resulting formation fractions:
+ ff
+cyan_JCZ38 5.890e-01
+cyan_J9Z38 2.318e-01
+cyan_sink 1.793e-01
+JCZ38_JSE76 1.000e+00
+JCZ38_sink 5.861e-12
+
+Estimated disappearance times:
+ DT50 DT90 DT50back DT50_k1 DT50_k2
+cyan 29.02 158.51 47.72 15.21 55.77
+JCZ38 22.27 73.98 NA NA NA
+J9Z38 113.09 375.69 NA NA NA
+JSE76 187.01 621.23 NA NA NA
+
+</code></pre>
+<p></p>
</div>
<div class="section level4">
<h4 id="pathway-2">Pathway 2<a class="anchor" aria-label="anchor" href="#pathway-2"></a>
@@ -3390,9 +3477,9 @@ Hierarchical FOMC path 2 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:32:26 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:40:28 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -3407,7 +3494,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1185.728 s
+Fitted in 499.317 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -3556,9 +3643,9 @@ Hierarchical DFOP path 2 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:34:49 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:41:25 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -3578,7 +3665,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1329.843 s
+Fitted in 555.724 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -3747,9 +3834,9 @@ Hierarchical DFOP path 2 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:41:05 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:44:08 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -3769,7 +3856,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1705.043 s
+Fitted in 718.988 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -3938,9 +4025,9 @@ Hierarchical SFORB path 2 fit with constant variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:35:39 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:41:22 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -3958,7 +4045,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1379.466 s
+Fitted in 553.276 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -4134,9 +4221,9 @@ Hierarchical SFORB path 2 fit with two-component error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 10:41:39 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:44:02 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -4154,7 +4241,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1739.402 s
+Fitted in 713.14 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -4335,9 +4422,9 @@ error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 11:12:56 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:57:07 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan
@@ -4352,7 +4439,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 1872.856 s
+Fitted in 776.732 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -4478,9 +4565,9 @@ variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 11:17:06 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:58:51 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -4500,7 +4587,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 2122.961 s
+Fitted in 880.94 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -4577,12 +4664,12 @@ f_JSE76_qlogis 1.9658 NA NA
log_k1 -1.9503 NA NA
log_k2 -4.4745 NA NA
g_qlogis -0.4967 NA NA
-a.1 2.7461 2.59886 2.8932
+a.1 2.7461 2.59274 2.8994
SD.log_k_JCZ38 1.3178 0.47602 2.1596
SD.log_k_J9Z38 0.7022 0.15061 1.2538
-SD.log_k_JSE76 0.6566 0.15614 1.1570
+SD.log_k_JSE76 0.6566 0.15613 1.1570
SD.f_cyan_ilr_1 0.3409 0.11666 0.5652
-SD.f_cyan_ilr_2 0.4385 0.09483 0.7821
+SD.f_cyan_ilr_2 0.4385 0.09482 0.7821
SD.log_k1 0.7381 0.25599 1.2202
SD.log_k2 0.5133 0.18152 0.8450
SD.g_qlogis 0.9866 0.35681 1.6164
@@ -4593,16 +4680,16 @@ Random effects:
est. lower upper
SD.log_k_JCZ38 1.3178 0.47602 2.1596
SD.log_k_J9Z38 0.7022 0.15061 1.2538
-SD.log_k_JSE76 0.6566 0.15614 1.1570
+SD.log_k_JSE76 0.6566 0.15613 1.1570
SD.f_cyan_ilr_1 0.3409 0.11666 0.5652
-SD.f_cyan_ilr_2 0.4385 0.09483 0.7821
+SD.f_cyan_ilr_2 0.4385 0.09482 0.7821
SD.log_k1 0.7381 0.25599 1.2202
SD.log_k2 0.5133 0.18152 0.8450
SD.g_qlogis 0.9866 0.35681 1.6164
Variance model:
est. lower upper
-a.1 2.746 2.599 2.893
+a.1 2.746 2.593 2.899
Backtransformed parameters:
est. lower upper
@@ -4644,9 +4731,9 @@ error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 11:17:59 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:58:58 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *
@@ -4666,7 +4753,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 2175.807 s
+Fitted in 887.853 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -4810,9 +4897,9 @@ variance
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 11:17:04 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:58:49 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -4830,7 +4917,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 2121.218 s
+Fitted in 878.878 s
Using 300, 100 iterations and 10 chains
Variance model: Constant variance
@@ -4981,9 +5068,9 @@ error
<pre><code>
saemix version used for fitting: 3.2
mkin version used for pre-fitting: 1.2.6
-R version used for fitting: 4.3.1
-Date of fit: Mon Oct 30 11:18:24 2023
-Date of summary: Mon Oct 30 11:18:27 2023
+R version used for fitting: 4.3.2
+Date of fit: Thu Nov 16 04:59:10 2023
+Date of summary: Thu Nov 16 04:59:11 2023
Equations:
d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound *
@@ -5001,7 +5088,7 @@ Data:
Model predictions using solution type deSolve
-Fitted in 2200.603 s
+Fitted in 899.539 s
Using 300, 100 iterations and 10 chains
Variance model: Two-component variance function
@@ -5150,23 +5237,23 @@ JSE76 25.44 84.51 NA NA NA
<div class="section level3">
<h3 id="session-info">Session info<a class="anchor" aria-label="anchor" href="#session-info"></a>
</h3>
-<pre><code>R version 4.3.1 (2023-06-16)
+<pre><code>R version 4.3.2 (2023-10-31)
Platform: x86_64-pc-linux-gnu (64-bit)
-Running under: Ubuntu 22.04.3 LTS
+Running under: Debian GNU/Linux 12 (bookworm)
Matrix products: default
-BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
-LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
+BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.11.0
+LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.11.0
locale:
- [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
- [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
- [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
- [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
+ [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C
+ [3] LC_TIME=de_DE.UTF-8 LC_COLLATE=de_DE.UTF-8
+ [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8
+ [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C
[9] LC_ADDRESS=C LC_TELEPHONE=C
-[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
+[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C
-time zone: Europe/Zurich
+time zone: Europe/Berlin
tzcode source: system (glibc)
attached base packages:
@@ -5174,62 +5261,55 @@ attached base packages:
[8] base
other attached packages:
-[1] saemix_3.2 npde_3.3 knitr_1.44 mkin_1.2.6
+[1] saemix_3.2 npde_3.3 knitr_1.42 mkin_1.2.6
loaded via a namespace (and not attached):
- [1] sass_0.4.7 utf8_1.2.3 generics_0.1.3 stringi_1.7.12
- [5] lattice_0.21-9 digest_0.6.33 magrittr_2.0.3 evaluate_0.22
- [9] grid_4.3.1 fastmap_1.1.1 cellranger_1.1.0 rprojroot_2.0.3
-[13] jsonlite_1.8.7 processx_3.8.2 pkgbuild_1.4.2 deSolve_1.35
-[17] mclust_6.0.0 ps_1.7.5 gridExtra_2.3 purrr_1.0.1
-[21] fansi_1.0.4 scales_1.2.1 codetools_0.2-19 textshaping_0.3.6
-[25] jquerylib_0.1.4 cli_3.6.1 crayon_1.5.2 rlang_1.1.1
-[29] munsell_0.5.0 cachem_1.0.8 yaml_2.3.7 inline_0.3.19
-[33] tools_4.3.1 memoise_2.0.1 dplyr_1.1.2 colorspace_2.1-0
-[37] ggplot2_3.4.2 vctrs_0.6.3 R6_2.5.1 zoo_1.8-12
-[41] lifecycle_1.0.3 stringr_1.5.0 fs_1.6.3 MASS_7.3-60
-[45] ragg_1.2.5 callr_3.7.3 pkgconfig_2.0.3 desc_1.4.2
-[49] pkgdown_2.0.7 bslib_0.5.1 pillar_1.9.0 gtable_0.3.3
-[53] glue_1.6.2 systemfonts_1.0.4 xfun_0.40 tibble_3.2.1
-[57] lmtest_0.9-40 tidyselect_1.2.0 rstudioapi_0.15.0 htmltools_0.5.6.1
-[61] nlme_3.1-163 rmarkdown_2.23 compiler_4.3.1 prettyunits_1.2.0
-[65] readxl_1.4.2 </code></pre>
+ [1] sass_0.4.6 utf8_1.2.3 generics_0.1.3 stringi_1.7.12
+ [5] lattice_0.21-8 digest_0.6.31 magrittr_2.0.3 evaluate_0.21
+ [9] grid_4.3.2 fastmap_1.1.1 cellranger_1.1.0 rprojroot_2.0.3
+[13] jsonlite_1.8.4 processx_3.8.1 pkgbuild_1.4.0 deSolve_1.35
+[17] DBI_1.1.3 mclust_6.0.0 ps_1.7.5 gridExtra_2.3
+[21] purrr_1.0.1 fansi_1.0.4 scales_1.2.1 codetools_0.2-19
+[25] textshaping_0.3.6 jquerylib_0.1.4 cli_3.6.1 crayon_1.5.2
+[29] rlang_1.1.1 munsell_0.5.0 cachem_1.0.8 yaml_2.3.7
+[33] inline_0.3.19 tools_4.3.2 memoise_2.0.1 dplyr_1.1.2
+[37] colorspace_2.1-0 ggplot2_3.4.2 vctrs_0.6.2 R6_2.5.1
+[41] zoo_1.8-12 lifecycle_1.0.3 stringr_1.5.0 fs_1.6.2
+[45] MASS_7.3-60 ragg_1.2.5 callr_3.7.3 pkgconfig_2.0.3
+[49] desc_1.4.2 pkgdown_2.0.7 bslib_0.4.2 pillar_1.9.0
+[53] gtable_0.3.3 glue_1.6.2 systemfonts_1.0.4 highr_0.10
+[57] xfun_0.39 tibble_3.2.1 lmtest_0.9-40 tidyselect_1.2.0
+[61] htmltools_0.5.5 nlme_3.1-163 rmarkdown_2.21 compiler_4.3.2
+[65] prettyunits_1.1.1 readxl_1.4.2 </code></pre>
</div>
<div class="section level3">
<h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a>
</h3>
-<pre><code>CPU model: Intel(R) Xeon(R) Gold 6134 CPU @ 3.20GHz</code></pre>
-<pre><code>MemTotal: 247605564 kB</code></pre>
+<pre><code>CPU model: AMD Ryzen 9 7950X 16-Core Processor</code></pre>
+<pre><code>MemTotal: 64927712 kB</code></pre>
</div>
</div>
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-
- <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2>
- </nav>
-</div>
-
+ </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+ </nav></aside>
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- <footer><div class="copyright">
+ <footer><div class="pkgdown-footer-left">
<p></p>
<p>Developed by Johannes Ranke.</p>
</div>
-<div class="pkgdown">
+<div class="pkgdown-footer-right">
<p></p>
<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
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