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+<meta property="og:description" content="This functions sets up a nonlinear mixed effects model for an mmkin row
+object. An mmkin row object is essentially a list of mkinfit objects that
+have been obtained by fitting the same model to a list of datasets." />
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+ <h1>Create an nlme model for an mmkin row object</h1>
+ <small class="dont-index">Source: <a href='http://github.com/jranke/mkin/blob/master/R/nlme.mmkin.R'><code>R/nlme.mmkin.R</code></a></small>
+ <div class="hidden name"><code>nlme.mmkin.Rd</code></div>
+ </div>
+
+ <div class="ref-description">
+ <p>This functions sets up a nonlinear mixed effects model for an mmkin row
+object. An mmkin row object is essentially a list of mkinfit objects that
+have been obtained by fitting the same model to a list of datasets.</p>
+ </div>
+
+ <pre class="usage"><span class='co'># S3 method for mmkin</span>
+<span class='fu'>nlme</span>(
+ <span class='no'>model</span>,
+ <span class='kw'>data</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/sys.parent.html'>sys.frame</a></span>(<span class='fu'><a href='https://rdrr.io/r/base/sys.parent.html'>sys.parent</a></span>()),
+ <span class='no'>fixed</span>,
+ <span class='kw'>random</span> <span class='kw'>=</span> <span class='no'>fixed</span>,
+ <span class='no'>groups</span>,
+ <span class='no'>start</span>,
+ <span class='kw'>correlation</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
+ <span class='kw'>weights</span> <span class='kw'>=</span> <span class='kw'>NULL</span>,
+ <span class='no'>subset</span>,
+ <span class='kw'>method</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span>(<span class='st'>"ML"</span>, <span class='st'>"REML"</span>),
+ <span class='kw'>na.action</span> <span class='kw'>=</span> <span class='no'>na.fail</span>,
+ <span class='no'>naPattern</span>,
+ <span class='kw'>control</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span>(),
+ <span class='kw'>verbose</span> <span class='kw'>=</span> <span class='fl'>FALSE</span>
+)
+
+<span class='co'># S3 method for nlme.mmkin</span>
+<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span>(<span class='no'>x</span>, <span class='no'>...</span>)
+
+<span class='co'># S3 method for nlme.mmkin</span>
+<span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span>(<span class='no'>object</span>, <span class='no'>...</span>)</pre>
+
+ <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2>
+ <table class="ref-arguments">
+ <colgroup><col class="name" /><col class="desc" /></colgroup>
+ <tr>
+ <th>model</th>
+ <td><p>An <code><a href='mmkin.html'>mmkin</a></code> row object.</p></td>
+ </tr>
+ <tr>
+ <th>data</th>
+ <td><p>Ignored, data are taken from the mmkin model</p></td>
+ </tr>
+ <tr>
+ <th>fixed</th>
+ <td><p>Ignored, all degradation parameters fitted in the
+mmkin model are used as fixed parameters</p></td>
+ </tr>
+ <tr>
+ <th>random</th>
+ <td><p>If not specified, all fixed effects are complemented
+with uncorrelated random effects</p></td>
+ </tr>
+ <tr>
+ <th>groups</th>
+ <td><p>See the documentation of nlme</p></td>
+ </tr>
+ <tr>
+ <th>start</th>
+ <td><p>If not specified, mean values of the fitted degradation
+parameters taken from the mmkin object are used</p></td>
+ </tr>
+ <tr>
+ <th>correlation</th>
+ <td><p>See the documentation of nlme</p></td>
+ </tr>
+ <tr>
+ <th>weights</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>subset</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>method</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>na.action</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>naPattern</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>control</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>verbose</th>
+ <td><p>passed to nlme</p></td>
+ </tr>
+ <tr>
+ <th>x</th>
+ <td><p>An nlme.mmkin object to print</p></td>
+ </tr>
+ <tr>
+ <th>...</th>
+ <td><p>Update specifications passed to update.nlme</p></td>
+ </tr>
+ <tr>
+ <th>object</th>
+ <td><p>An nlme.mmkin object to update</p></td>
+ </tr>
+ </table>
+
+ <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2>
+
+ <p>Upon success, a fitted nlme.mmkin object, which is an nlme object
+with additional elements</p>
+ <h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
+
+ <div class='dont-index'><p><code><a href='nlme.html'>nlme_function</a></code></p></div>
+
+ <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
+ <pre class="examples"><div class='input'><span class='no'>ds</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span>(<span class='no'>experimental_data_for_UBA_2019</span>[<span class='fl'>6</span>:<span class='fl'>10</span>],
+ <span class='kw'>function</span>(<span class='no'>x</span>) <span class='fu'><a href='https://rdrr.io/r/base/subset.html'>subset</a></span>(<span class='no'>x</span>$<span class='no'>data</span>[<span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span>(<span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span>)], <span class='no'>name</span> <span class='kw'>==</span> <span class='st'>"parent"</span>))
+<span class='no'>f</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span>(<span class='st'>"SFO"</span>, <span class='no'>ds</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>, <span class='kw'>cores</span> <span class='kw'>=</span> <span class='fl'>1</span>)
+<span class='fu'><a href='https://rdrr.io/r/base/library.html'>library</a></span>(<span class='no'>nlme</span>)
+<span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>f</span><span class='kw'>[[</span><span class='fl'>1</span>]])</div><div class='output co'>#&gt; $distimes
+#&gt; DT50 DT90
+#&gt; parent 11.96183 39.73634
+#&gt; </div><div class='input'><span class='no'>f_nlme</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f</span>)
+<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span>(<span class='no'>f_nlme</span>)</div><div class='output co'>#&gt; Nonlinear mixed-effects model fit by maximum likelihood
+#&gt; Model: value ~ (mkin::get_deg_func())(name, time, parent_0, log_k_parent_sink)
+#&gt; Data: "Not shown"
+#&gt; Log-likelihood: -307.5269
+#&gt; Fixed: list(parent_0 ~ 1, log_k_parent_sink ~ 1)
+#&gt; parent_0 log_k_parent_sink
+#&gt; 85.540979 -3.229602
+#&gt;
+#&gt; Random effects:
+#&gt; Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1)
+#&gt; Level: ds
+#&gt; Structure: Diagonal
+#&gt; parent_0 log_k_parent_sink Residual
+#&gt; StdDev: 1.308245 1.288586 6.304923
+#&gt;
+#&gt; Number of Observations: 90
+#&gt; Number of Groups: 5 </div><div class='input'><span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>f_nlme</span>)</div><div class='output co'>#&gt; $distimes
+#&gt; DT50 DT90
+#&gt; parent 17.51556 58.18543
+#&gt; </div><div class='input'><span class='co'># \dontrun{</span>
+ <span class='no'>f_nlme_2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f</span>, <span class='kw'>start</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span>(<span class='kw'>parent_0</span> <span class='kw'>=</span> <span class='fl'>100</span>, <span class='kw'>log_k_parent_sink</span> <span class='kw'>=</span> <span class='fl'>0.1</span>))
+ <span class='fu'><a href='https://rdrr.io/r/stats/update.html'>update</a></span>(<span class='no'>f_nlme_2</span>, <span class='kw'>random</span> <span class='kw'>=</span> <span class='no'>parent_0</span> ~ <span class='fl'>1</span>)</div><div class='output co'>#&gt; Nonlinear mixed-effects model fit by maximum likelihood
+#&gt; Model: value ~ (mkin::get_deg_func())(name, time, parent_0, log_k_parent_sink)
+#&gt; Data: "Not shown"
+#&gt; Log-likelihood: -404.3729
+#&gt; Fixed: list(parent_0 ~ 1, log_k_parent_sink ~ 1)
+#&gt; parent_0 log_k_parent_sink
+#&gt; 75.933480 -3.555983
+#&gt;
+#&gt; Random effects:
+#&gt; Formula: parent_0 ~ 1 | ds
+#&gt; parent_0 Residual
+#&gt; StdDev: 0.002416802 21.63027
+#&gt;
+#&gt; Number of Observations: 90
+#&gt; Number of Groups: 5 </div><div class='input'> <span class='co'># Test on some real data</span>
+ <span class='no'>ds_2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span>(<span class='no'>experimental_data_for_UBA_2019</span>[<span class='fl'>6</span>:<span class='fl'>10</span>],
+ <span class='kw'>function</span>(<span class='no'>x</span>) <span class='no'>x</span>$<span class='no'>data</span>[<span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span>(<span class='st'>"name"</span>, <span class='st'>"time"</span>, <span class='st'>"value"</span>)])
+ <span class='no'>m_sfo_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"A1"</span>),
+ <span class='kw'>A1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"min"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
+ <span class='no'>m_sfo_sfo_ff</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>, <span class='st'>"A1"</span>),
+ <span class='kw'>A1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>use_of_ff</span> <span class='kw'>=</span> <span class='st'>"max"</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
+ <span class='no'>m_fomc_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"FOMC"</span>, <span class='st'>"A1"</span>),
+ <span class='kw'>A1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
+ <span class='no'>m_dfop_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span>(<span class='kw'>parent</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"DFOP"</span>, <span class='st'>"A1"</span>),
+ <span class='kw'>A1</span> <span class='kw'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span>(<span class='st'>"SFO"</span>), <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
+
+ <span class='no'>f_2</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span>(<span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span>(<span class='st'>"SFO-SFO"</span> <span class='kw'>=</span> <span class='no'>m_sfo_sfo</span>,
+ <span class='st'>"SFO-SFO-ff"</span> <span class='kw'>=</span> <span class='no'>m_sfo_sfo_ff</span>,
+ <span class='st'>"FOMC-SFO"</span> <span class='kw'>=</span> <span class='no'>m_fomc_sfo</span>,
+ <span class='st'>"DFOP-SFO"</span> <span class='kw'>=</span> <span class='no'>m_dfop_sfo</span>),
+ <span class='no'>ds_2</span>, <span class='kw'>quiet</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)
+ <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_2</span>[<span class='st'>"SFO-SFO"</span>, <span class='fl'>3</span>:<span class='fl'>4</span>]) <span class='co'># Separate fits for datasets 3 and 4</span></div><div class='img'><img src='nlme.mmkin-1.png' alt='' width='700' height='433' /></div><div class='input'>
+ <span class='no'>f_nlme_sfo_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f_2</span>[<span class='st'>"SFO-SFO"</span>, ])
+ <span class='co'># plot(f_nlme_sfo_sfo) # not feasible with pkgdown figures</span>
+ <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_nlme_sfo_sfo</span>, <span class='fl'>3</span>:<span class='fl'>4</span>) <span class='co'># Global mixed model: Fits for datasets 3 and 4</span></div><div class='img'><img src='nlme.mmkin-2.png' alt='' width='700' height='433' /></div><div class='input'>
+ <span class='co'># With formation fractions</span>
+ <span class='no'>f_nlme_sfo_sfo_ff</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f_2</span>[<span class='st'>"SFO-SFO-ff"</span>, ])
+ <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_nlme_sfo_sfo_ff</span>, <span class='fl'>3</span>:<span class='fl'>4</span>) <span class='co'># chi2 different due to different df attribution</span></div><div class='img'><img src='nlme.mmkin-3.png' alt='' width='700' height='433' /></div><div class='input'>
+ <span class='co'># For more parameters, we need to increase pnlsMaxIter and the tolerance</span>
+ <span class='co'># to get convergence</span>
+ <span class='no'>f_nlme_fomc_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f_2</span>[<span class='st'>"FOMC-SFO"</span>, ],
+ <span class='kw'>control</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span>(<span class='kw'>pnlsMaxIter</span> <span class='kw'>=</span> <span class='fl'>100</span>, <span class='kw'>tolerance</span> <span class='kw'>=</span> <span class='fl'>1e-4</span>), <span class='kw'>verbose</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt;
+#&gt; **Iteration 1
+#&gt; LME step: Loglik: -394.1603, nlminb iterations: 2
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5
+#&gt; -0.2079863 0.8563823 1.7454253 1.0917707 1.2756955
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 643.8814
+#&gt; fixed effects: 94.17379 -5.473189 -0.6970234 -0.202509 2.103883
+#&gt; iterations: 100
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0001):
+#&gt; fixed reStruct
+#&gt; 0.7959873 0.1447512
+#&gt;
+#&gt; **Iteration 2
+#&gt; LME step: Loglik: -396.3824, nlminb iterations: 7
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5
+#&gt; -1.712406e-01 -2.278541e-05 1.842120e+00 1.073975e+00 1.322924e+00
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 643.8025
+#&gt; fixed effects: 94.17385 -5.473491 -0.6970406 -0.2025139 2.103871
+#&gt; iterations: 100
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0001):
+#&gt; fixed reStruct
+#&gt; 5.51758e-05 1.26861e-03
+#&gt;
+#&gt; **Iteration 3
+#&gt; LME step: Loglik: -396.3825, nlminb iterations: 7
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5
+#&gt; -0.1712500923 -0.0001515734 1.8420972550 1.0739796967 1.3229177241
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 643.7941
+#&gt; fixed effects: 94.17386 -5.473523 -0.6970424 -0.2025146 2.103869
+#&gt; iterations: 100
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0001):
+#&gt; fixed reStruct
+#&gt; 5.792621e-06 1.335434e-04
+#&gt;
+#&gt; **Iteration 4
+#&gt; LME step: Loglik: -396.3825, nlminb iterations: 7
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5
+#&gt; -0.1712517206 -0.0001651603 1.8420950864 1.0739800294 1.3229173529
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 643.7949
+#&gt; fixed effects: 94.17386 -5.473521 -0.6970423 -0.2025145 2.10387
+#&gt; iterations: 100
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0001):
+#&gt; fixed reStruct
+#&gt; 4.025781e-07 9.628656e-06 </div><div class='input'> <span class='no'>f_nlme_dfop_sfo</span> <span class='kw'>&lt;-</span> <span class='fu'><a href='https://rdrr.io/pkg/nlme/man/nlme.html'>nlme</a></span>(<span class='no'>f_2</span>[<span class='st'>"DFOP-SFO"</span>, ],
+ <span class='kw'>control</span> <span class='kw'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/list.html'>list</a></span>(<span class='kw'>pnlsMaxIter</span> <span class='kw'>=</span> <span class='fl'>120</span>, <span class='kw'>tolerance</span> <span class='kw'>=</span> <span class='fl'>5e-4</span>), <span class='kw'>verbose</span> <span class='kw'>=</span> <span class='fl'>TRUE</span>)</div><div class='output co'>#&gt;
+#&gt; **Iteration 1
+#&gt; LME step: Loglik: -404.9583, nlminb iterations: 1
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5 ds6
+#&gt; -0.4114357 0.9798641 1.6990035 0.7293314 0.3354323 1.7113047
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 630.3642
+#&gt; fixed effects: 93.82269 -5.455991 -0.6788957 -1.862196 -4.199671 0.0553284
+#&gt; iterations: 120
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0005):
+#&gt; fixed reStruct
+#&gt; 0.7879730 0.5822574
+#&gt;
+#&gt; **Iteration 2
+#&gt; LME step: Loglik: -407.7755, nlminb iterations: 11
+#&gt; reStruct parameters:
+#&gt; ds1 ds2 ds3 ds4 ds5 ds6
+#&gt; -0.371224105 0.003056163 1.789939431 0.724671132 0.301602942 1.754200482
+#&gt; Beginning PNLS step: .. completed fit_nlme() step.
+#&gt; PNLS step: RSS = 630.364
+#&gt; fixed effects: 93.82269 -5.455991 -0.6788958 -1.862196 -4.199671 0.05532834
+#&gt; iterations: 120
+#&gt; Convergence crit. (must all become &lt;= tolerance = 0.0005):
+#&gt; fixed reStruct
+#&gt; 9.814652e-07 1.059239e-05 </div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_2</span>[<span class='st'>"FOMC-SFO"</span>, <span class='fl'>3</span>:<span class='fl'>4</span>])</div><div class='img'><img src='nlme.mmkin-4.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_nlme_fomc_sfo</span>, <span class='fl'>3</span>:<span class='fl'>4</span>)</div><div class='img'><img src='nlme.mmkin-5.png' alt='' width='700' height='433' /></div><div class='input'>
+ <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_2</span>[<span class='st'>"DFOP-SFO"</span>, <span class='fl'>3</span>:<span class='fl'>4</span>])</div><div class='img'><img src='nlme.mmkin-6.png' alt='' width='700' height='433' /></div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/base/plot.html'>plot</a></span>(<span class='no'>f_nlme_dfop_sfo</span>, <span class='fl'>3</span>:<span class='fl'>4</span>)</div><div class='img'><img src='nlme.mmkin-7.png' alt='' width='700' height='433' /></div><div class='input'>
+ <span class='fu'><a href='https://rdrr.io/r/stats/anova.html'>anova</a></span>(<span class='no'>f_nlme_dfop_sfo</span>, <span class='no'>f_nlme_fomc_sfo</span>, <span class='no'>f_nlme_sfo_sfo</span>)</div><div class='output co'>#&gt; Model df AIC BIC logLik Test L.Ratio p-value
+#&gt; f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274
+#&gt; f_nlme_fomc_sfo 2 11 818.5151 853.0089 -398.2576 1 vs 2 21.33957 &lt;.0001
+#&gt; f_nlme_sfo_sfo 3 9 1085.1821 1113.4043 -533.5910 2 vs 3 270.66697 &lt;.0001</div><div class='input'> <span class='fu'><a href='https://rdrr.io/r/stats/anova.html'>anova</a></span>(<span class='no'>f_nlme_dfop_sfo</span>, <span class='no'>f_nlme_sfo_sfo</span>) <span class='co'># if we ignore FOMC</span></div><div class='output co'>#&gt; Model df AIC BIC logLik Test L.Ratio p-value
+#&gt; f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274
+#&gt; f_nlme_sfo_sfo 2 9 1085.1821 1113.4043 -533.5910 1 vs 2 249.3274 &lt;.0001</div><div class='input'>
+ <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>f_nlme_sfo_sfo</span>)</div><div class='output co'>#&gt; $ff
+#&gt; parent_sink parent_A1 A1_sink
+#&gt; 0.5912432 0.4087568 1.0000000
+#&gt;
+#&gt; $distimes
+#&gt; DT50 DT90
+#&gt; parent 19.13518 63.5657
+#&gt; A1 66.02155 219.3189
+#&gt; </div><div class='input'> <span class='fu'><a href='endpoints.html'>endpoints</a></span>(<span class='no'>f_nlme_dfop_sfo</span>)</div><div class='output co'>#&gt; $ff
+#&gt; parent_A1 parent_sink
+#&gt; 0.2768574 0.7231426
+#&gt;
+#&gt; $distimes
+#&gt; DT50 DT90 DT50_k1 DT50_k2
+#&gt; parent 11.07091 104.6320 4.462384 46.20825
+#&gt; A1 162.30518 539.1661 NA NA
+#&gt; </div><div class='input'># }
+</div></pre>
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