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Optionally +(default is FALSE), the data are listed in full.</p> + </div> + + <pre class="usage"><span class='co'># S3 method for saem.mmkin</span> +<span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>object</span>, data <span class='op'>=</span> <span class='cn'>FALSE</span>, verbose <span class='op'>=</span> <span class='cn'>FALSE</span>, distimes <span class='op'>=</span> <span class='cn'>TRUE</span>, <span class='va'>...</span><span class='op'>)</span> + +<span class='co'># S3 method for summary.saem.mmkin</span> +<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, digits <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/Extremes.html'>max</a></span><span class='op'>(</span><span class='fl'>3</span>, <span class='fu'><a href='https://rdrr.io/r/base/options.html'>getOption</a></span><span class='op'>(</span><span class='st'>"digits"</span><span class='op'>)</span> <span class='op'>-</span> <span class='fl'>3</span><span class='op'>)</span>, verbose <span class='op'>=</span> <span class='va'>x</span><span class='op'>$</span><span class='va'>verbose</span>, <span class='va'>...</span><span class='op'>)</span></pre> + + <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> + <table class="ref-arguments"> + <colgroup><col class="name" /><col class="desc" /></colgroup> + <tr> + <th>object</th> + <td><p>an object of class <a href='saem.html'>saem.mmkin</a></p></td> + </tr> + <tr> + <th>data</th> + <td><p>logical, indicating whether the full data should be included in +the summary.</p></td> + </tr> + <tr> + <th>verbose</th> + <td><p>Should the summary be verbose?</p></td> + </tr> + <tr> + <th>distimes</th> + <td><p>logical, indicating whether DT50 and DT90 values should be +included.</p></td> + </tr> + <tr> + <th>...</th> + <td><p>optional arguments passed to methods like <code>print</code>.</p></td> + </tr> + <tr> + <th>x</th> + <td><p>an object of class summary.saem.mmkin</p></td> + </tr> + <tr> + <th>digits</th> + <td><p>Number of digits to use for printing</p></td> + </tr> + </table> + + <h2 class="hasAnchor" id="value"><a class="anchor" href="#value"></a>Value</h2> + + <p>The summary function returns a list based on the <a href='https://rdrr.io/pkg/saemix/man/SaemixObject-class.html'>saemix::SaemixObject</a> +obtained in the fit, with at least the following additional components</p> +<dt>saemixversion, mkinversion, Rversion</dt><dd><p>The saemix, mkin and R versions used</p></dd> +<dt>date.fit, date.summary</dt><dd><p>The dates where the fit and the summary were +produced</p></dd> +<dt>diffs</dt><dd><p>The differential equations used in the degradation model</p></dd> +<dt>use_of_ff</dt><dd><p>Was maximum or minimum use made of formation fractions</p></dd> +<dt>data</dt><dd><p>The data</p></dd> +<dt>confint_trans</dt><dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> +<dt>confint_back</dt><dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> +<dt>ff</dt><dd><p>The estimated formation fractions derived from the fitted +model.</p></dd> +<dt>distimes</dt><dd><p>The DT50 and DT90 values for each observed variable.</p></dd> +<dt>SFORB</dt><dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> +The print method is called for its side effect, i.e. printing the summary. + + <h2 class="hasAnchor" id="author"><a class="anchor" href="#author"></a>Author</h2> + + <p>Johannes Ranke for the mkin specific parts +saemix authors for the parts inherited from saemix.</p> + + <h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2> + <pre class="examples"><div class='input'><span class='co'># Generate five datasets following SFO kinetics</span> +<span class='va'>sampling_times</span> <span class='op'>=</span> <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>0</span>, <span class='fl'>1</span>, <span class='fl'>3</span>, <span class='fl'>7</span>, <span class='fl'>14</span>, <span class='fl'>28</span>, <span class='fl'>60</span>, <span class='fl'>90</span>, <span class='fl'>120</span><span class='op'>)</span> +<span class='va'>dt50_sfo_in_pop</span> <span class='op'><-</span> <span class='fl'>50</span> +<span class='va'>k_in_pop</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='fl'>2</span><span class='op'>)</span> <span class='op'>/</span> <span class='va'>dt50_sfo_in_pop</span> +<span class='fu'><a href='https://rdrr.io/r/base/Random.html'>set.seed</a></span><span class='op'>(</span><span class='fl'>1234</span><span class='op'>)</span> +<span class='va'>k_in</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/stats/Lognormal.html'>rlnorm</a></span><span class='op'>(</span><span class='fl'>5</span>, <span class='fu'><a href='https://rdrr.io/r/base/Log.html'>log</a></span><span class='op'>(</span><span class='va'>k_in_pop</span><span class='op'>)</span>, <span class='fl'>0.5</span><span class='op'>)</span> +<span class='va'>SFO</span> <span class='op'><-</span> <span class='fu'><a href='mkinmod.html'>mkinmod</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fu'><a href='mkinsub.html'>mkinsub</a></span><span class='op'>(</span><span class='st'>"SFO"</span><span class='op'>)</span><span class='op'>)</span> + +<span class='va'>pred_sfo</span> <span class='op'><-</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>k</span><span class='op'>)</span> <span class='op'>{</span> + <span class='fu'><a href='mkinpredict.html'>mkinpredict</a></span><span class='op'>(</span><span class='va'>SFO</span>, + <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>k_parent <span class='op'>=</span> <span class='va'>k</span><span class='op'>)</span>, + <span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span>parent <span class='op'>=</span> <span class='fl'>100</span><span class='op'>)</span>, + <span class='va'>sampling_times</span><span class='op'>)</span> +<span class='op'>}</span> + +<span class='va'>ds_sfo_mean</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>k_in</span>, <span class='va'>pred_sfo</span><span class='op'>)</span> +<span class='fu'><a href='https://rdrr.io/r/base/names.html'>names</a></span><span class='op'>(</span><span class='va'>ds_sfo_mean</span><span class='op'>)</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/paste.html'>paste</a></span><span class='op'>(</span><span class='st'>"ds"</span>, <span class='fl'>1</span><span class='op'>:</span><span class='fl'>5</span><span class='op'>)</span> + +<span class='va'>ds_sfo_syn</span> <span class='op'><-</span> <span class='fu'><a href='https://rdrr.io/r/base/lapply.html'>lapply</a></span><span class='op'>(</span><span class='va'>ds_sfo_mean</span>, <span class='kw'>function</span><span class='op'>(</span><span class='va'>ds</span><span class='op'>)</span> <span class='op'>{</span> + <span class='fu'><a href='add_err.html'>add_err</a></span><span class='op'>(</span><span class='va'>ds</span>, + sdfunc <span class='op'>=</span> <span class='kw'>function</span><span class='op'>(</span><span class='va'>value</span><span class='op'>)</span> <span class='fu'><a href='https://rdrr.io/r/base/MathFun.html'>sqrt</a></span><span class='op'>(</span><span class='fl'>1</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>+</span> <span class='va'>value</span><span class='op'>^</span><span class='fl'>2</span> <span class='op'>*</span> <span class='fl'>0.07</span><span class='op'>^</span><span class='fl'>2</span><span class='op'>)</span>, + n <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span><span class='op'>[[</span><span class='fl'>1</span><span class='op'>]</span><span class='op'>]</span> +<span class='op'>}</span><span class='op'>)</span> + +<span class='co'># \dontrun{</span> +<span class='co'># Evaluate using mmkin and saem</span> +<span class='va'>f_mmkin</span> <span class='op'><-</span> <span class='fu'><a href='mmkin.html'>mmkin</a></span><span class='op'>(</span><span class='st'>"SFO"</span>, <span class='va'>ds_sfo_syn</span>, quiet <span class='op'>=</span> <span class='cn'>TRUE</span>, error_model <span class='op'>=</span> <span class='st'>"tc"</span>, cores <span class='op'>=</span> <span class='fl'>1</span><span class='op'>)</span> +<span class='va'>f_saem</span> <span class='op'><-</span> <span class='fu'><a href='saem.html'>saem</a></span><span class='op'>(</span><span class='va'>f_mmkin</span><span class='op'>)</span> +</div><div class='output co'>#> Running main SAEM algorithm +#> [1] "Sun Nov 8 02:58:03 2020" +#> .... +#> Minimisation finished +#> [1] "Sun Nov 8 02:58:07 2020"</div><div class='input'><span class='fu'><a href='https://rdrr.io/pkg/saemix/man/summary-methods.html'>summary</a></span><span class='op'>(</span><span class='va'>f_saem</span>, data <span class='op'>=</span> <span class='cn'>TRUE</span><span class='op'>)</span> +</div><div class='output co'>#> saemix version used for fitting: 3.1.9000 +#> mkin version used for pre-fitting: 0.9.50.4 +#> R version used for fitting: 4.0.3 +#> Date of fit: Sun Nov 8 02:58:07 2020 +#> Date of summary: Sun Nov 8 02:58:07 2020 +#> +#> Equations: +#> d_parent/dt = - k_parent * parent +#> +#> Data: +#> 90 observations of 1 variable(s) grouped in 5 datasets +#> +#> Model predictions using solution type analytical +#> +#> Fitted in 4.175 s using 300, 100 iterations +#> +#> Variance model: Two-component variance function +#> +#> Mean of starting values for individual parameters: +#> parent_0 log_k_parent +#> 97.849556 -4.455036 +#> +#> Fixed degradation parameter values: +#> None +#> +#> Results: +#> +#> Likelihood computed by importance sampling +#> AIC BIC logLik +#> 555.6718 553.3284 -271.8359 +#> +#> Optimised, transformed parameters with symmetric confidence intervals: +#> est. lower upper +#> parent_0 97.840291 94.701895 100.978686 +#> log_k_parent -4.464246 -5.001413 -3.927078 +#> +#> Correlation: +#> prnt_0 +#> log_k_parent 0.022 +#> +#> Random effects: +#> est. lower upper +#> SD.parent_0 3.0805465 0.4960170 5.6650760 +#> SD.log_k_parent 0.6109508 0.2301398 0.9917617 +#> +#> Variance model: +#> est. lower upper +#> a.1 1.06249961 0.23012265 1.89487657 +#> b.1 0.04649661 0.03060849 0.06238473 +#> +#> Backtransformed parameters with asymmetric confidence intervals: +#> est. lower upper +#> parent_0 97.84029088 94.701895315 100.97868644 +#> k_parent 0.01151338 0.006728434 0.01970115 +#> +#> Estimated disappearance times: +#> DT50 DT90 +#> parent 60.2 200 +#> +#> Data: +#> ds name time observed predicted residual standardized +#> ds 1 parent 0 103.6 97.303 6.297361 -1.12720 +#> ds 1 parent 0 95.9 97.303 -1.402639 0.25107 +#> ds 1 parent 1 95.4 96.599 -1.198705 0.21583 +#> ds 1 parent 1 95.3 96.599 -1.298705 0.23383 +#> ds 1 parent 3 91.6 95.206 -3.606076 0.65693 +#> ds 1 parent 3 94.5 95.206 -0.706076 0.12863 +#> ds 1 parent 7 88.1 92.481 -4.380761 0.81692 +#> ds 1 parent 7 89.6 92.481 -2.880761 0.53720 +#> ds 1 parent 14 90.3 87.898 2.402166 -0.46649 +#> ds 1 parent 14 96.0 87.898 8.102166 -1.57340 +#> ds 1 parent 28 80.2 79.402 0.797948 -0.16783 +#> ds 1 parent 28 77.9 79.402 -1.502052 0.31593 +#> ds 1 parent 60 59.3 62.940 -3.639829 0.91247 +#> ds 1 parent 60 59.6 62.940 -3.339829 0.83726 +#> ds 1 parent 90 59.4 50.620 8.779547 -2.56999 +#> ds 1 parent 90 51.0 50.620 0.379547 -0.11110 +#> ds 1 parent 120 38.8 40.712 -1.912380 0.64706 +#> ds 1 parent 120 38.9 40.712 -1.812380 0.61323 +#> ds 2 parent 0 103.2 97.185 6.015158 -1.07774 +#> ds 2 parent 0 95.1 97.185 -2.084842 0.37354 +#> ds 2 parent 1 88.3 95.609 -7.309466 1.32706 +#> ds 2 parent 1 102.4 95.609 6.790534 -1.23285 +#> ds 2 parent 3 88.4 92.535 -4.134911 0.77071 +#> ds 2 parent 3 95.2 92.535 2.665089 -0.49675 +#> ds 2 parent 7 83.5 86.679 -3.179231 0.62426 +#> ds 2 parent 7 96.4 86.679 9.720769 -1.90873 +#> ds 2 parent 14 77.3 77.309 -0.009268 0.00199 +#> ds 2 parent 14 76.0 77.309 -1.309268 0.28113 +#> ds 2 parent 28 61.7 61.499 0.201491 -0.05137 +#> ds 2 parent 28 56.5 61.499 -4.998509 1.27449 +#> ds 2 parent 60 35.1 36.454 -1.353571 0.49087 +#> ds 2 parent 60 32.2 36.454 -4.253571 1.54256 +#> ds 2 parent 90 21.2 22.326 -1.125996 0.53604 +#> ds 2 parent 90 23.3 22.326 0.974004 -0.46368 +#> ds 2 parent 120 14.1 13.674 0.426440 -0.25110 +#> ds 2 parent 120 16.9 13.674 3.226440 -1.89983 +#> ds 3 parent 0 92.4 93.838 -1.437848 0.26501 +#> ds 3 parent 0 94.0 93.838 0.162152 -0.02989 +#> ds 3 parent 1 95.7 91.709 3.991384 -0.74932 +#> ds 3 parent 1 90.8 91.709 -0.908616 0.17058 +#> ds 3 parent 3 86.7 87.594 -0.893997 0.17409 +#> ds 3 parent 3 85.8 87.594 -1.793997 0.34934 +#> ds 3 parent 7 77.1 79.910 -2.810299 0.58817 +#> ds 3 parent 7 81.5 79.910 1.589701 -0.33271 +#> ds 3 parent 14 69.1 68.050 1.050102 -0.24845 +#> ds 3 parent 14 62.4 68.050 -5.649898 1.33675 +#> ds 3 parent 28 49.1 49.349 -0.248837 0.07412 +#> ds 3 parent 28 47.2 49.349 -2.148837 0.64010 +#> ds 3 parent 60 21.9 23.676 -1.775776 0.82085 +#> ds 3 parent 60 23.6 23.676 -0.075776 0.03503 +#> ds 3 parent 90 12.4 11.892 0.507660 -0.31425 +#> ds 3 parent 90 13.8 11.892 1.907660 -1.18088 +#> ds 3 parent 120 4.9 5.974 -1.073521 0.80099 +#> ds 3 parent 120 7.5 5.974 1.526479 -1.13895 +#> ds 4 parent 0 91.8 102.087 -10.287197 1.77084 +#> ds 4 parent 0 104.6 102.087 2.512803 -0.43256 +#> ds 4 parent 1 117.5 101.632 15.867689 -2.74145 +#> ds 4 parent 1 99.3 101.632 -2.332311 0.40295 +#> ds 4 parent 3 94.0 100.729 -6.728610 1.17100 +#> ds 4 parent 3 98.7 100.729 -2.028610 0.35304 +#> ds 4 parent 7 109.2 98.945 10.254756 -1.81080 +#> ds 4 parent 7 89.2 98.945 -9.745244 1.72083 +#> ds 4 parent 14 103.3 95.900 7.400009 -1.34021 +#> ds 4 parent 14 103.0 95.900 7.100009 -1.28588 +#> ds 4 parent 28 90.8 90.088 0.712227 -0.13563 +#> ds 4 parent 28 88.7 90.088 -1.387773 0.26427 +#> ds 4 parent 60 74.8 78.091 -3.291273 0.70124 +#> ds 4 parent 60 75.3 78.091 -2.791273 0.59471 +#> ds 4 parent 90 71.1 68.300 2.800407 -0.66075 +#> ds 4 parent 90 78.0 68.300 9.700407 -2.28880 +#> ds 4 parent 120 59.1 59.736 -0.635668 0.16554 +#> ds 4 parent 120 53.8 59.736 -5.935668 1.54574 +#> ds 5 parent 0 94.9 98.353 -3.452694 0.61266 +#> ds 5 parent 0 101.8 98.353 3.447306 -0.61171 +#> ds 5 parent 1 96.1 96.722 -0.621996 0.11187 +#> ds 5 parent 1 97.1 96.722 0.378004 -0.06799 +#> ds 5 parent 3 93.8 93.541 0.258738 -0.04781 +#> ds 5 parent 3 85.8 93.541 -7.741262 1.43043 +#> ds 5 parent 7 87.6 87.490 0.109848 -0.02141 +#> ds 5 parent 7 94.0 87.490 6.509848 -1.26885 +#> ds 5 parent 14 82.5 77.827 4.672679 -0.99818 +#> ds 5 parent 14 81.7 77.827 3.872679 -0.82728 +#> ds 5 parent 28 60.0 61.585 -1.585419 0.40382 +#> ds 5 parent 28 61.0 61.585 -0.585419 0.14911 +#> ds 5 parent 60 32.5 36.068 -3.568284 1.30251 +#> ds 5 parent 60 35.5 36.068 -0.568284 0.20744 +#> ds 5 parent 90 21.8 21.842 -0.042136 0.02028 +#> ds 5 parent 90 24.4 21.842 2.557864 -1.23088 +#> ds 5 parent 120 14.1 13.227 0.872898 -0.52035 +#> ds 5 parent 120 12.1 13.227 -1.127102 0.67189</div><div class='input'><span class='co'># }</span> + +</div></pre> + </div> + <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> + <nav id="toc" data-toggle="toc" class="sticky-top"> + <h2 data-toc-skip>Contents</h2> + </nav> + </div> +</div> + + + <footer> + <div class="copyright"> 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