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Therefore this transformation was used originally in mkin. It -was later replaced by the ilr transformation because the ilr transformed -fractions can assumed to follow normal distribution. As the ilr -transformation is not available in RxODE and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in nlmixr_model. 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Therefore this transformation was used originally in mkin. It -was later replaced by the <a href="ilr.html">ilr</a> transformation because the ilr transformed -fractions can assumed to follow normal distribution. As the ilr -transformation is not available in <a href="https://nlmixrdevelopment.github.io/RxODE/reference/RxODE.html" class="external-link">RxODE</a> and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in <a href="nlmixr.mmkin.html">nlmixr_model</a>. However, -this implementation cannot be used there, as it is not accessible -from RxODE.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">tffm0</span><span class="op">(</span><span class="va">ff</span><span class="op">)</span> - -<span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_trans</span><span class="op">)</span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>ff</dt> -<dd><p>Vector of untransformed formation fractions. The sum -must be smaller or equal to one</p></dd> -<dt>ff_trans</dt> -<dd><p>Vector of transformed formation fractions that can be -restricted to the interval from 0 to 1</p></dd> -</dl></div> - <div id="value"> - <h2>Value</h2> - <p>A vector of the transformed formation fractions -A vector of backtransformed formation fractions for natural use in degradation models</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">ff_example</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="fl">0.10983681</span>, <span class="fl">0.09035905</span>, <span class="fl">0.08399383</span></span> -<span class="r-in"><span class="op">)</span></span> -<span class="r-in"><span class="va">ff_example_trans</span> <span class="op"><-</span> <span class="fu">tffm0</span><span class="op">(</span><span class="va">ff_example</span><span class="op">)</span></span> -<span class="r-in"><span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_example_trans</span><span class="op">)</span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.10983681 0.09035905 0.08399383</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> -</div> - - </footer></div> - - - - - - - </body></html> - |