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- <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/2022_wp_1.1_dmta_parent.rmd" class="external-link"><code>vignettes/2022_wp_1.1_dmta_parent.rmd</code></a></small> - <div class="hidden name"><code>2022_wp_1.1_dmta_parent.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>The purpose of this document is to demonstrate how nonlinear -hierarchical models (NLHM) based on the parent degradation models SFO, -FOMC, DFOP and HS can be fitted with the mkin package.</p> -<p>The mkin package is used in version 1.2.2. It contains the test data -and the functions used in the evaluations. The <code>saemix</code> -package is used as a backend for fitting the NLHM, but is also loaded to -make the convergence plot function available.</p> -<p>This document is processed with the <code>knitr</code> package, which -also provides the <code>kable</code> function that is used to improve -the display of tabular data in R markdown documents. For parallel -processing, the <code>parallel</code> package is used.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://yihui.org/knitr/" class="external-link">knitr</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">parallel</span><span class="op">)</span></span> -<span><span class="va">n_cores</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span> -<span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makeForkCluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<div class="section level3"> -<h3 id="preprocessing-of-test-data">Preprocessing of test data<a class="anchor" aria-label="anchor" href="#preprocessing-of-test-data"></a> -</h3> -<p>The test data are available in the mkin package as an object of class -<code>mkindsg</code> (mkin dataset group) under the identifier -<code>dimethenamid_2018</code>. The following preprocessing steps are -still necessary:</p> -<ul> -<li>The data available for the enantiomer dimethenamid-P (DMTAP) are -renamed to have the same substance name as the data for the racemic -mixture dimethenamid (DMTA). The reason for this is that no difference -between their degradation behaviour was identified in the EU risk -assessment.</li> -<li>The data for transformation products and unnecessary columns are -discarded</li> -<li>The observation times of each dataset are multiplied with the -corresponding normalisation factor also available in the dataset, in -order to make it possible to describe all datasets with a single set of -parameters that are independent of temperature</li> -<li>Finally, datasets observed in the same soil (<code>Elliot 1</code> -and <code>Elliot 2</code>) are combined, resulting in dimethenamid -(DMTA) data from six soils.</li> -</ul> -<p>The following commented R code performs this preprocessing.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="co"># Apply a function to each of the seven datasets in the mkindsg object to create a list</span></span> -<span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span> <span class="co"># Get a dataset</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span> <span class="co"># Rename DMTAP to DMTA</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">ds_i</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"DMTA"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">)</span> <span class="co"># Select data</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span> <span class="co"># Normalise time</span></span> -<span> <span class="va">ds_i</span> <span class="co"># Return the dataset</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Use dataset titles as names for the list elements</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Combine data for Elliot soil to obtain a named list with six elements</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> <span class="co">#</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -<p>The following tables show the 6 datasets.</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">for</span> <span class="op">(</span><span class="va">ds_name</span> <span class="kw">in</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="fu"><a href="../reference/mkin_long_to_wide.html">mkin_long_to_wide</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="va">ds_name</span><span class="op">]</span><span class="op">]</span><span class="op">)</span>,</span> -<span> caption <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="va">ds_name</span><span class="op">)</span>,</span> -<span> label <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"tab:"</span>, <span class="va">ds_name</span><span class="op">)</span>, booktabs <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span><span class="st">"\n\\clearpage\n"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<table class="table"> -<caption>Dataset Calke</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0</td> -<td align="right">95.8</td> -</tr> -<tr class="even"> -<td align="right">0</td> -<td align="right">98.7</td> -</tr> -<tr class="odd"> -<td align="right">14</td> -<td align="right">60.5</td> -</tr> -<tr class="even"> -<td align="right">30</td> -<td align="right">39.1</td> -</tr> -<tr class="odd"> -<td align="right">59</td> -<td align="right">15.2</td> -</tr> -<tr class="even"> -<td align="right">120</td> -<td align="right">4.8</td> -</tr> -<tr class="odd"> -<td align="right">120</td> -<td align="right">4.6</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Borstel</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">100.5</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">99.6</td> -</tr> -<tr class="odd"> -<td align="right">1.941295</td> -<td align="right">91.9</td> -</tr> -<tr class="even"> -<td align="right">1.941295</td> -<td align="right">91.3</td> -</tr> -<tr class="odd"> -<td align="right">6.794534</td> -<td align="right">81.8</td> -</tr> -<tr class="even"> -<td align="right">6.794534</td> -<td align="right">82.1</td> -</tr> -<tr class="odd"> -<td align="right">13.589067</td> -<td align="right">69.1</td> -</tr> -<tr class="even"> -<td align="right">13.589067</td> -<td align="right">68.0</td> -</tr> -<tr class="odd"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -</tr> -<tr class="even"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -</tr> -<tr class="odd"> -<td align="right">56.297565</td> -<td align="right">27.6</td> -</tr> -<tr class="even"> -<td align="right">56.297565</td> -<td align="right">26.8</td> -</tr> -<tr class="odd"> -<td align="right">86.387643</td> -<td align="right">15.7</td> -</tr> -<tr class="even"> -<td align="right">86.387643</td> -<td align="right">15.3</td> -</tr> -<tr class="odd"> -<td align="right">115.507073</td> -<td align="right">7.9</td> -</tr> -<tr class="even"> -<td align="right">115.507073</td> -<td align="right">8.1</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Flaach</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">96.5</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">96.8</td> -</tr> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">97.0</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">82.9</td> -</tr> -<tr class="odd"> -<td align="right">0.6233856</td> -<td align="right">86.7</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">87.4</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">72.8</td> -</tr> -<tr class="even"> -<td align="right">1.8701567</td> -<td align="right">69.9</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">71.9</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">51.4</td> -</tr> -<tr class="odd"> -<td align="right">4.3636989</td> -<td align="right">52.9</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">48.6</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">28.5</td> -</tr> -<tr class="even"> -<td align="right">8.7273979</td> -<td align="right">27.3</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">27.5</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.8</td> -</tr> -<tr class="odd"> -<td align="right">13.0910968</td> -<td align="right">13.4</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.4</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">7.7</td> -</tr> -<tr class="even"> -<td align="right">17.4547957</td> -<td align="right">7.3</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">8.1</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">2.0</td> -</tr> -<tr class="odd"> -<td align="right">26.1821936</td> -<td align="right">1.5</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">1.9</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.3</td> -</tr> -<tr class="even"> -<td align="right">34.9095915</td> -<td align="right">1.0</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.1</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.9</td> -</tr> -<tr class="odd"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.6</td> -</tr> -<tr class="even"> -<td align="right">52.3643872</td> -<td align="right">0.4</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.5</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.4</td> -</tr> -<tr class="odd"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.2</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">98.09</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">98.77</td> -</tr> -<tr class="odd"> -<td align="right">0.7678922</td> -<td align="right">93.52</td> -</tr> -<tr class="even"> -<td align="right">0.7678922</td> -<td align="right">92.03</td> -</tr> -<tr class="odd"> -<td align="right">2.3036765</td> -<td align="right">88.39</td> -</tr> -<tr class="even"> -<td align="right">2.3036765</td> -<td align="right">87.18</td> -</tr> -<tr class="odd"> -<td align="right">5.3752452</td> -<td align="right">69.38</td> -</tr> -<tr class="even"> -<td align="right">5.3752452</td> -<td align="right">71.06</td> -</tr> -<tr class="odd"> -<td align="right">10.7504904</td> -<td align="right">45.21</td> -</tr> -<tr class="even"> -<td align="right">10.7504904</td> -<td align="right">46.81</td> -</tr> -<tr class="odd"> -<td align="right">16.1257355</td> -<td align="right">30.54</td> -</tr> -<tr class="even"> -<td align="right">16.1257355</td> -<td align="right">30.07</td> -</tr> -<tr class="odd"> -<td align="right">21.5009807</td> -<td align="right">21.60</td> -</tr> -<tr class="even"> -<td align="right">21.5009807</td> -<td align="right">20.41</td> -</tr> -<tr class="odd"> -<td align="right">32.2514711</td> -<td align="right">9.10</td> -</tr> -<tr class="even"> -<td align="right">32.2514711</td> -<td align="right">9.70</td> -</tr> -<tr class="odd"> -<td align="right">43.0019614</td> -<td align="right">6.58</td> -</tr> -<tr class="even"> -<td align="right">43.0019614</td> -<td align="right">6.31</td> -</tr> -<tr class="odd"> -<td align="right">53.7524518</td> -<td align="right">3.47</td> -</tr> -<tr class="even"> -<td align="right">53.7524518</td> -<td align="right">3.52</td> -</tr> -<tr class="odd"> -<td align="right">64.5029421</td> -<td align="right">3.40</td> -</tr> -<tr class="even"> -<td align="right">64.5029421</td> -<td align="right">3.67</td> -</tr> -<tr class="odd"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -</tr> -<tr class="even"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.3</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">99.33</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">97.44</td> -</tr> -<tr class="odd"> -<td align="right">0.6733938</td> -<td align="right">93.73</td> -</tr> -<tr class="even"> -<td align="right">0.6733938</td> -<td align="right">93.77</td> -</tr> -<tr class="odd"> -<td align="right">2.0201814</td> -<td align="right">87.84</td> -</tr> -<tr class="even"> -<td align="right">2.0201814</td> -<td align="right">89.82</td> -</tr> -<tr class="odd"> -<td align="right">4.7137565</td> -<td align="right">71.61</td> -</tr> -<tr class="even"> -<td align="right">4.7137565</td> -<td align="right">71.42</td> -</tr> -<tr class="odd"> -<td align="right">9.4275131</td> -<td align="right">45.60</td> -</tr> -<tr class="even"> -<td align="right">9.4275131</td> -<td align="right">45.42</td> -</tr> -<tr class="odd"> -<td align="right">14.1412696</td> -<td align="right">31.12</td> -</tr> -<tr class="even"> -<td align="right">14.1412696</td> -<td align="right">31.68</td> -</tr> -<tr class="odd"> -<td align="right">18.8550262</td> -<td align="right">23.20</td> -</tr> -<tr class="even"> -<td align="right">18.8550262</td> -<td align="right">24.13</td> -</tr> -<tr class="odd"> -<td align="right">28.2825393</td> -<td align="right">9.43</td> -</tr> -<tr class="even"> -<td align="right">28.2825393</td> -<td align="right">9.82</td> -</tr> -<tr class="odd"> -<td align="right">37.7100523</td> -<td align="right">7.08</td> -</tr> -<tr class="even"> -<td align="right">37.7100523</td> -<td align="right">8.64</td> -</tr> -<tr class="odd"> -<td align="right">47.1375654</td> -<td align="right">4.41</td> -</tr> -<tr class="even"> -<td align="right">47.1375654</td> -<td align="right">4.78</td> -</tr> -<tr class="odd"> -<td align="right">56.5650785</td> -<td align="right">4.92</td> -</tr> -<tr class="even"> -<td align="right">56.5650785</td> -<td align="right">5.08</td> -</tr> -<tr class="odd"> -<td align="right">80.1338612</td> -<td align="right">2.13</td> -</tr> -<tr class="even"> -<td align="right">80.1338612</td> -<td align="right">2.23</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Elliot</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">97.5</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">100.7</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">86.4</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">88.5</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">69.8</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">77.1</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">59.0</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">54.2</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">31.3</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.5</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">19.6</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">13.3</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">15.8</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">6.7</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">8.8</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">6.0</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">3.3</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">2.8</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">1.4</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.8</td> -</tr> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">93.4</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">103.2</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">89.2</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">86.6</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">78.2</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">78.1</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">55.6</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">53.0</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">33.7</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.2</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">19.9</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">18.2</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">12.7</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">7.8</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">9.0</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">11.4</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">9.0</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">3.9</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">2.6</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">3.4</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">2.0</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.7</td> -</tr> -</tbody> -</table> -</div> -</div> -<div class="section level2"> -<h2 id="separate-evaluations">Separate evaluations<a class="anchor" aria-label="anchor" href="#separate-evaluations"></a> -</h2> -<p>In order to obtain suitable starting parameters for the NLHM fits, -separate fits of the four models to the data for each soil are generated -using the <code>mmkin</code> function from the <code>mkin</code> -package. In a first step, constant variance is assumed. Convergence is -checked with the <code>status</code> function.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">deg_mods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span></span> -<span><span class="va">f_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span></span> -<span> <span class="va">deg_mods</span>,</span> -<span> <span class="va">dmta_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu"><a href="../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_const</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>In the table above, OK indicates convergence, and C indicates failure -to converge. All separate fits with constant variance converged, with -the sole exception of the HS fit to the BBA 2.2 data. To prepare for -fitting NLHM using the two-component error model, the separate fits are -updated assuming two-component error.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>Using the two-component error model, the one fit that did not -converge with constant variance did converge, but other non-SFO fits -failed to converge.</p> -</div> -<div class="section level2"> -<h2 id="hierarchichal-model-fits">Hierarchichal model fits<a class="anchor" aria-label="anchor" href="#hierarchichal-model-fits"></a> -</h2> -<p>The following code fits eight versions of hierarchical models to the -data, using SFO, FOMC, DFOP and HS for the parent compound, and using -either constant variance or two-component error for the error model. The -default parameter distribution model in mkin allows for variation of all -degradation parameters across the assumed population of soils. In other -words, each degradation parameter is associated with a random effect as -a first step. The <code>mhmkin</code> function makes it possible to fit -all eight versions in parallel (given a sufficient number of computing -cores being available) to save execution time.</p> -<p>Convergence plots and summaries for these fits are shown in the -appendix.</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_sep_const</span>, <span class="va">f_sep_tc</span><span class="op">)</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span></code></pre></div> -<p>The output of the <code>status</code> function shows that all fits -terminated successfully.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>The AIC and BIC values show that the biphasic models DFOP and HS give -the best fits.</p> -<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO const</td> -<td align="right">5</td> -<td align="right">796.3</td> -<td align="right">795.3</td> -<td align="right">-393.2</td> -</tr> -<tr class="even"> -<td align="left">SFO tc</td> -<td align="right">6</td> -<td align="right">798.3</td> -<td align="right">797.1</td> -<td align="right">-393.2</td> -</tr> -<tr class="odd"> -<td align="left">FOMC const</td> -<td align="right">7</td> -<td align="right">734.2</td> -<td align="right">732.7</td> -<td align="right">-360.1</td> -</tr> -<tr class="even"> -<td align="left">FOMC tc</td> -<td align="right">8</td> -<td align="right">720.4</td> -<td align="right">718.8</td> -<td align="right">-352.2</td> -</tr> -<tr class="odd"> -<td align="left">DFOP const</td> -<td align="right">9</td> -<td align="right">711.8</td> -<td align="right">710.0</td> -<td align="right">-346.9</td> -</tr> -<tr class="even"> -<td align="left">HS const</td> -<td align="right">9</td> -<td align="right">714.0</td> -<td align="right">712.1</td> -<td align="right">-348.0</td> -</tr> -<tr class="odd"> -<td align="left">DFOP tc</td> -<td align="right">10</td> -<td align="right">665.5</td> -<td align="right">663.4</td> -<td align="right">-322.8</td> -</tr> -<tr class="even"> -<td align="left">HS tc</td> -<td align="right">10</td> -<td align="right">667.1</td> -<td align="right">665.0</td> -<td align="right">-323.6</td> -</tr> -</tbody> -</table> -<p>The DFOP model is preferred here, as it has a better mechanistic -basis for batch experiments with constant incubation conditions. Also, -it shows the lowest AIC and BIC values in the first set of fits when -combined with the two-component error model. Therefore, the DFOP model -was selected for further refinements of the fits with the aim to make -the model fully identifiable.</p> -<div class="section level3"> -<h3 id="parameter-identifiability-based-on-the-fisher-information-matrix">Parameter identifiability based on the Fisher Information -Matrix<a class="anchor" aria-label="anchor" href="#parameter-identifiability-based-on-the-fisher-information-matrix"></a> -</h3> -<p>Using the <code>illparms</code> function, ill-defined statistical -model parameters such as standard deviations of the degradation -parameters in the population and error model parameters can be -found.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left"></td> -<td align="left">b.1</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left"></td> -<td align="left">sd(DMTA_0)</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">sd(k2)</td> -<td align="left">sd(k2)</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left"></td> -<td align="left">sd(tb)</td> -</tr> -</tbody> -</table> -<p>According to the <code>illparms</code> function, the fitted standard -deviation of the second kinetic rate constant <code>k2</code> is -ill-defined in both DFOP fits. This suggests that different values would -be obtained for this standard deviation when using different starting -values.</p> -<p>The thus identified overparameterisation is addressed by removing the -random effect for <code>k2</code> from the parameter model.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_no_ranef_k2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"k2"</span><span class="op">)</span></span></code></pre></div> -<p>For the resulting fit, it is checked whether there are still -ill-defined parameters,</p> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<p>which is not the case. Below, the refined model is compared with the -previous best model. The model without random effect for <code>k2</code> -is a reduced version of the previous model. Therefore, the models are -nested and can be compared using the likelihood ratio test. This is -achieved with the argument <code>test = TRUE</code> to the -<code>anova</code> function.</p> -<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>, <span class="va">f_saem_dfop_tc_no_ranef_k2</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="op">|></span></span> -<span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>format.args <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">4</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<colgroup> -<col width="37%"> -<col width="6%"> -<col width="8%"> -<col width="8%"> -<col width="9%"> -<col width="9%"> -<col width="4%"> -<col width="15%"> -</colgroup> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -<th align="right">Chisq</th> -<th align="right">Df</th> -<th align="right">Pr(>Chisq)</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">f_saem_dfop_tc_no_ranef_k2</td> -<td align="right">9</td> -<td align="right">663.8</td> -<td align="right">661.9</td> -<td align="right">-322.9</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="left">f_saem[[“DFOP”, “tc”]]</td> -<td align="right">10</td> -<td align="right">665.5</td> -<td align="right">663.4</td> -<td align="right">-322.8</td> -<td align="right">0.2809</td> -<td align="right">1</td> -<td align="right">0.5961</td> -</tr> -</tbody> -</table> -<p>The AIC and BIC criteria are lower after removal of the ill-defined -random effect for <code>k2</code>. The p value of the likelihood ratio -test is much greater than 0.05, indicating that the model with the -higher likelihood (here the model with random effects for all -degradation parameters <code>f_saem[["DFOP", "tc"]]</code>) does not fit -significantly better than the model with the lower likelihood (the -reduced model <code>f_saem_dfop_tc_no_ranef_k2</code>).</p> -<p>Therefore, AIC, BIC and likelihood ratio test suggest the use of the -reduced model.</p> -<p>The convergence of the fit is checked visually.</p> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-tc-no-ranef-k2-1.png" alt="Convergence plot for the NLHM DFOP fit with two-component error and without a random effect on 'k2'" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with two-component error and -without a random effect on ‘k2’ -</p> -</div> -<p>All parameters appear to have converged to a satisfactory degree. The -final fit is plotted using the plot method from the mkin package.</p> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/plot-saem-dfop-tc-no-ranef-k2-1.png" alt="Plot of the final NLHM DFOP fit" width="864"><p class="caption"> -Plot of the final NLHM DFOP fit -</p> -</div> -<p>Finally, a summary report of the fit is produced.</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<pre><code>saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:13 2023 -Date of summary: Thu Jan 5 08:19:13 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 4.075 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.759266 0.087034 0.009933 0.930827 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.76 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 663.8 661.9 -322.9 - -Optimised parameters: - est. lower upper -DMTA_0 98.228939 96.285869 100.17201 -k1 0.064063 0.033477 0.09465 -k2 0.008297 0.005824 0.01077 -g 0.953821 0.914328 0.99331 -a.1 1.068479 0.869538 1.26742 -b.1 0.029424 0.022406 0.03644 -SD.DMTA_0 2.030437 0.404824 3.65605 -SD.k1 0.594692 0.256660 0.93272 -SD.g 1.006754 0.361327 1.65218 - -Correlation: - DMTA_0 k1 k2 -k1 0.0218 -k2 0.0556 0.0355 -g -0.0516 -0.0284 -0.2800 - -Random effects: - est. lower upper -SD.DMTA_0 2.0304 0.4048 3.6560 -SD.k1 0.5947 0.2567 0.9327 -SD.g 1.0068 0.3613 1.6522 - -Variance model: - est. lower upper -a.1 1.06848 0.86954 1.26742 -b.1 0.02942 0.02241 0.03644 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.45 41.4 12.46 10.82 83.54</code></pre> -</div> -<div class="section level3"> -<h3 id="alternative-check-of-parameter-identifiability">Alternative check of parameter identifiability<a class="anchor" aria-label="anchor" href="#alternative-check-of-parameter-identifiability"></a> -</h3> -<p>The parameter check used in the <code>illparms</code> function is -based on a quadratic approximation of the likelihood surface near its -optimum, which is calculated using the Fisher Information Matrix (FIM). -An alternative way to check parameter identifiability based on a -multistart approach has recently been implemented in mkin.</p> -<p>The graph below shows boxplots of the parameters obtained in 50 runs -of the saem algorithm with different parameter combinations, sampled -from the range of the parameters obtained for the individual datasets -fitted separately using nonlinear regression.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_multi</span> <span class="op"><-</span> <span class="fu"><a href="../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>, n <span class="op">=</span> <span class="fl">50</span>, cores <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_multi</span>, lpos <span class="op">=</span> <span class="st">"bottomright"</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.3</span>, <span class="fl">10</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/multistart-full-par-1.png" alt="Scaled parameters from the multistart runs, full model" width="960"><p class="caption"> -Scaled parameters from the multistart runs, full model -</p> -</div> -<p>The graph clearly confirms the lack of identifiability of the -variance of <code>k2</code> in the full model. The overparameterisation -of the model also indicates a lack of identifiability of the variance of -parameter <code>g</code>.</p> -<p>The parameter boxplots of the multistart runs with the reduced model -shown below indicate that all runs give similar results, regardless of -the starting parameters.</p> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span> <span class="op"><-</span> <span class="fu"><a href="../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span>,</span> -<span> n <span class="op">=</span> <span class="fl">50</span>, cores <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomright"</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/multistart-reduced-par-1.png" alt="Scaled parameters from the multistart runs, reduced model" width="960"><p class="caption"> -Scaled parameters from the multistart runs, reduced model -</p> -</div> -<p>When only the parameters of the top 25% of the fits are shown (based -on a feature introduced in mkin 1.2.2 currently under development), the -scatter is even less as shown below.</p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span>, llquant <span class="op">=</span> <span class="fl">0.25</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomright"</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/multistart-reduced-par-llquant-1.png" alt="Scaled parameters from the multistart runs, reduced model, fits with the top 25\% likelihood values" width="960"><p class="caption"> -Scaled parameters from the multistart runs, reduced model, fits with the -top 25% likelihood values -</p> -</div> -</div> -</div> -<div class="section level2"> -<h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#conclusions"></a> -</h2> -<p>Fitting the four parent degradation models SFO, FOMC, DFOP and HS as -part of hierarchical model fits with two different error models and -normal distributions of the transformed degradation parameters works -without technical problems. The biphasic models DFOP and HS gave the -best fit to the data, but the default parameter distribution model was -not fully identifiable. Removing the random effect for the second -kinetic rate constant of the DFOP model resulted in a reduced model that -was fully identifiable and showed the lowest values for the model -selection criteria AIC and BIC. The reliability of the identification of -all model parameters was confirmed using multiple starting values.</p> -</div> -<div class="section level2"> -<h2 id="appendix">Appendix<a class="anchor" aria-label="anchor" href="#appendix"></a> -</h2> -<div class="section level3"> -<h3 id="hierarchical-model-fit-listings">Hierarchical model fit listings<a class="anchor" aria-label="anchor" href="#hierarchical-model-fit-listings"></a> -</h3> -<caption> -Hierarchical mkin fit of the SFO model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:06 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - k_DMTA * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 1.09 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k_DMTA -97.2953 0.0566 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k_DMTA -DMTA_0 97.3 0 -k_DMTA 0.0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 796.3 795.3 -393.2 - -Optimised parameters: - est. lower upper -DMTA_0 97.28130 95.71113 98.8515 -k_DMTA 0.05665 0.02909 0.0842 -a.1 2.66442 2.35579 2.9731 -SD.DMTA_0 1.54776 0.15447 2.9411 -SD.k_DMTA 0.60690 0.26248 0.9513 - -Correlation: - DMTA_0 -k_DMTA 0.0168 - -Random effects: - est. lower upper -SD.DMTA_0 1.5478 0.1545 2.9411 -SD.k_DMTA 0.6069 0.2625 0.9513 - -Variance model: - est. lower upper -a.1 2.664 2.356 2.973 - -Estimated disappearance times: - DT50 DT90 -DMTA 12.24 40.65 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the SFO model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:07 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - k_DMTA * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.441 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k_DMTA -96.99175 0.05603 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k_DMTA -DMTA_0 96.99 0 -k_DMTA 0.00 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 798.3 797.1 -393.2 - -Optimised parameters: - est. lower upper -DMTA_0 97.271822 95.703157 98.84049 -k_DMTA 0.056638 0.029110 0.08417 -a.1 2.660081 2.230398 3.08976 -b.1 0.001665 -0.006911 0.01024 -SD.DMTA_0 1.545520 0.145035 2.94601 -SD.k_DMTA 0.606422 0.262274 0.95057 - -Correlation: - DMTA_0 -k_DMTA 0.0169 - -Random effects: - est. lower upper -SD.DMTA_0 1.5455 0.1450 2.9460 -SD.k_DMTA 0.6064 0.2623 0.9506 - -Variance model: - est. lower upper -a.1 2.660081 2.230398 3.08976 -b.1 0.001665 -0.006911 0.01024 - -Estimated disappearance times: - DT50 DT90 -DMTA 12.24 40.65 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the FOMC model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:06 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - (alpha/beta) * 1/((time/beta) + 1) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 1.156 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 alpha beta - 98.292 9.909 156.341 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 alpha beta -DMTA_0 98.29 0 0 -alpha 0.00 1 0 -beta 0.00 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 734.2 732.7 -360.1 - -Optimised parameters: - est. lower upper -DMTA_0 98.3435 96.9033 99.784 -alpha 7.2007 2.5889 11.812 -beta 112.8746 34.8816 190.868 -a.1 2.0459 1.8054 2.286 -SD.DMTA_0 1.4795 0.2717 2.687 -SD.alpha 0.6396 0.1509 1.128 -SD.beta 0.6874 0.1587 1.216 - -Correlation: - DMTA_0 alpha -alpha -0.1125 -beta -0.1227 0.3632 - -Random effects: - est. lower upper -SD.DMTA_0 1.4795 0.2717 2.687 -SD.alpha 0.6396 0.1509 1.128 -SD.beta 0.6874 0.1587 1.216 - -Variance model: - est. lower upper -a.1 2.046 1.805 2.286 - -Estimated disappearance times: - DT50 DT90 DT50back -DMTA 11.41 42.53 12.8 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the FOMC model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:07 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - (alpha/beta) * 1/((time/beta) + 1) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.729 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: -DMTA_0 alpha beta -98.772 4.663 92.597 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 alpha beta -DMTA_0 98.77 0 0 -alpha 0.00 1 0 -beta 0.00 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 720.4 718.8 -352.2 - -Optimised parameters: - est. lower upper -DMTA_0 98.99136 97.26011 100.72261 -alpha 5.86312 2.57485 9.15138 -beta 88.55571 29.20889 147.90254 -a.1 1.51063 1.24384 1.77741 -b.1 0.02824 0.02040 0.03609 -SD.DMTA_0 1.57436 -0.04867 3.19739 -SD.alpha 0.59871 0.17132 1.02611 -SD.beta 0.72994 0.22849 1.23139 - -Correlation: - DMTA_0 alpha -alpha -0.1363 -beta -0.1414 0.2542 - -Random effects: - est. lower upper -SD.DMTA_0 1.5744 -0.04867 3.197 -SD.alpha 0.5987 0.17132 1.026 -SD.beta 0.7299 0.22849 1.231 - -Variance model: - est. lower upper -a.1 1.51063 1.2438 1.77741 -b.1 0.02824 0.0204 0.03609 - -Estimated disappearance times: - DT50 DT90 DT50back -DMTA 11.11 42.6 12.82 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the DFOP model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:07 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.007 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.64383 0.09211 0.02999 0.76814 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.64 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 711.8 710 -346.9 - -Optimised parameters: - est. lower upper -DMTA_0 98.092481 96.573898 99.61106 -k1 0.062499 0.030336 0.09466 -k2 0.009065 -0.005133 0.02326 -g 0.948967 0.862079 1.03586 -a.1 1.821671 1.604774 2.03857 -SD.DMTA_0 1.677785 0.472066 2.88350 -SD.k1 0.634962 0.270788 0.99914 -SD.k2 1.033498 -0.205994 2.27299 -SD.g 1.710046 0.428642 2.99145 - -Correlation: - DMTA_0 k1 k2 -k1 0.0246 -k2 0.0491 0.0953 -g -0.0552 -0.0889 -0.4795 - -Random effects: - est. lower upper -SD.DMTA_0 1.678 0.4721 2.8835 -SD.k1 0.635 0.2708 0.9991 -SD.k2 1.033 -0.2060 2.2730 -SD.g 1.710 0.4286 2.9914 - -Variance model: - est. lower upper -a.1 1.822 1.605 2.039 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.79 42.8 12.88 11.09 76.46 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the DFOP model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:08 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 3.033 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.759266 0.087034 0.009933 0.930827 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.76 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 665.5 663.4 -322.8 - -Optimised parameters: - est. lower upper -DMTA_0 98.377019 96.447952 100.30609 -k1 0.064843 0.034607 0.09508 -k2 0.008895 0.006368 0.01142 -g 0.949696 0.903815 0.99558 -a.1 1.065241 0.865754 1.26473 -b.1 0.029340 0.022336 0.03634 -SD.DMTA_0 2.007754 0.387982 3.62753 -SD.k1 0.580473 0.250286 0.91066 -SD.k2 0.006105 -4.920337 4.93255 -SD.g 1.097149 0.412779 1.78152 - -Correlation: - DMTA_0 k1 k2 -k1 0.0235 -k2 0.0595 0.0424 -g -0.0470 -0.0278 -0.2731 - -Random effects: - est. lower upper -SD.DMTA_0 2.007754 0.3880 3.6275 -SD.k1 0.580473 0.2503 0.9107 -SD.k2 0.006105 -4.9203 4.9325 -SD.g 1.097149 0.4128 1.7815 - -Variance model: - est. lower upper -a.1 1.06524 0.86575 1.26473 -b.1 0.02934 0.02234 0.03634 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.36 41.32 12.44 10.69 77.92 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the HS model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:07 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - ifelse(time <= tb, k1, k2) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.004 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k1 k2 tb -97.82176 0.06931 0.02997 11.13945 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 tb -DMTA_0 97.82 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -tb 0.00 0 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 714 712.1 -348 - -Optimised parameters: - est. lower upper -DMTA_0 98.16102 96.47747 99.84456 -k1 0.07876 0.05261 0.10491 -k2 0.02227 0.01706 0.02747 -tb 13.99089 -7.40049 35.38228 -a.1 1.82305 1.60700 2.03910 -SD.DMTA_0 1.88413 0.56204 3.20622 -SD.k1 0.34292 0.10482 0.58102 -SD.k2 0.19851 0.01718 0.37985 -SD.tb 1.68168 0.58064 2.78272 - -Correlation: - DMTA_0 k1 k2 -k1 0.0142 -k2 0.0001 -0.0025 -tb 0.0165 -0.1256 -0.0301 - -Random effects: - est. lower upper -SD.DMTA_0 1.8841 0.56204 3.2062 -SD.k1 0.3429 0.10482 0.5810 -SD.k2 0.1985 0.01718 0.3798 -SD.tb 1.6817 0.58064 2.7827 - -Variance model: - est. lower upper -a.1 1.823 1.607 2.039 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 8.801 67.91 20.44 8.801 31.13 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the HS model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Thu Jan 5 08:19:08 2023 -Date of summary: Thu Jan 5 08:20:11 2023 - -Equations: -d_DMTA/dt = - ifelse(time <= tb, k1, k2) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 3.287 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 tb -98.45190 0.07525 0.02576 19.19375 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 tb -DMTA_0 98.45 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -tb 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 667.1 665 -323.6 - -Optimised parameters: - est. lower upper -DMTA_0 97.76570 95.81350 99.71791 -k1 0.05855 0.03080 0.08630 -k2 0.02337 0.01664 0.03010 -tb 31.09638 29.38289 32.80987 -a.1 1.08835 0.88590 1.29080 -b.1 0.02964 0.02257 0.03671 -SD.DMTA_0 2.04877 0.42607 3.67147 -SD.k1 0.59166 0.25621 0.92711 -SD.k2 0.30698 0.09561 0.51835 -SD.tb 0.01274 -0.10914 0.13462 - -Correlation: - DMTA_0 k1 k2 -k1 0.0160 -k2 -0.0070 -0.0024 -tb -0.0668 -0.0103 -0.2013 - -Random effects: - est. lower upper -SD.DMTA_0 2.04877 0.42607 3.6715 -SD.k1 0.59166 0.25621 0.9271 -SD.k2 0.30698 0.09561 0.5183 -SD.tb 0.01274 -0.10914 0.1346 - -Variance model: - est. lower upper -a.1 1.08835 0.88590 1.29080 -b.1 0.02964 0.02257 0.03671 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.84 51.71 15.57 11.84 29.66 - -</code></pre> -<p></p> -</div> -<div class="section level3"> -<h3 id="hierarchical-model-convergence-plots">Hierarchical model convergence plots<a class="anchor" aria-label="anchor" href="#hierarchical-model-convergence-plots"></a> -</h3> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-sfo-const-1.png" alt="Convergence plot for the NLHM SFO fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM SFO fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-sfo-tc-1.png" alt="Convergence plot for the NLHM SFO fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM SFO fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-fomc-const-1.png" alt="Convergence plot for the NLHM FOMC fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM FOMC fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-fomc-tc-1.png" alt="Convergence plot for the NLHM FOMC fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM FOMC fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png" alt="Convergence plot for the NLHM DFOP fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-tc-1.png" alt="Convergence plot for the NLHM DFOP fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-hs-const-1.png" alt="Convergence plot for the NLHM HS fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM HS fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-hs-tc-1.png" alt="Convergence plot for the NLHM HS fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM HS fit with two-component error -</p> -</div> -</div> -<div class="section level3"> -<h3 id="session-info">Session info<a class="anchor" aria-label="anchor" href="#session-info"></a> -</h3> -<pre><code>R version 4.2.2 Patched (2022-11-10 r83330) -Platform: x86_64-pc-linux-gnu (64-bit) -Running under: Debian GNU/Linux bookworm/sid - -Matrix products: default -BLAS: /usr/lib/x86_64-linux-gnu/openblas-serial/libblas.so.3 -LAPACK: /usr/lib/x86_64-linux-gnu/openblas-serial/libopenblas-r0.3.21.so - -locale: - [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C - [3] LC_TIME=de_DE.UTF-8 LC_COLLATE=de_DE.UTF-8 - [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8 - [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C - [9] LC_ADDRESS=C LC_TELEPHONE=C -[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C - -attached base packages: -[1] parallel stats graphics grDevices utils datasets methods -[8] base - -other attached packages: -[1] saemix_3.2 npde_3.3 knitr_1.41 mkin_1.2.2 - -loaded via a namespace (and not attached): - [1] deSolve_1.34 zoo_1.8-11 tidyselect_1.2.0 xfun_0.35 - [5] bslib_0.4.2 purrr_1.0.0 lattice_0.20-45 colorspace_2.0-3 - [9] vctrs_0.5.1 generics_0.1.3 htmltools_0.5.4 yaml_2.3.6 -[13] utf8_1.2.2 rlang_1.0.6 pkgdown_2.0.7 jquerylib_0.1.4 -[17] pillar_1.8.1 glue_1.6.2 DBI_1.1.3 lifecycle_1.0.3 -[21] stringr_1.5.0 munsell_0.5.0 gtable_0.3.1 ragg_1.2.4 -[25] codetools_0.2-18 memoise_2.0.1 evaluate_0.19 fastmap_1.1.0 -[29] lmtest_0.9-40 fansi_1.0.3 highr_0.9 scales_1.2.1 -[33] cachem_1.0.6 desc_1.4.2 jsonlite_1.8.4 systemfonts_1.0.4 -[37] fs_1.5.2 textshaping_0.3.6 gridExtra_2.3 ggplot2_3.4.0 -[41] digest_0.6.31 stringi_1.7.8 dplyr_1.0.10 grid_4.2.2 -[45] rprojroot_2.0.3 cli_3.5.0 tools_4.2.2 magrittr_2.0.3 -[49] sass_0.4.4 tibble_3.1.8 pkgconfig_2.0.3 assertthat_0.2.1 -[53] rmarkdown_2.19 R6_2.5.1 mclust_6.0.0 nlme_3.1-161 -[57] compiler_4.2.2 </code></pre> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png b/docs/dev/articles/2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png Binary files differdeleted file mode 100644 index 4f87b956..00000000 --- a/docs/dev/articles/2022_wp_1.1_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png +++ /dev/null diff --git 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dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Example evaluation of FOCUS Example Dataset -D</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 31 January 2019 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_D.rmd" class="external-link"><code>vignettes/FOCUS_D.rmd</code></a></small> - <div class="hidden name"><code>FOCUS_D.rmd</code></div> - - </div> - - - -<p>This is just a very simple vignette showing how to fit a degradation -model for a parent compound with one transformation product using -<code>mkin</code>. After loading the library we look at the data. We -have observed concentrations in the column named <code>value</code> at -the times specified in column <code>time</code> for the two observed -variables named <code>parent</code> and <code>m1</code>.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## name time value</span></span> -<span><span class="co">## 1 parent 0 99.46</span></span> -<span><span class="co">## 2 parent 0 102.04</span></span> -<span><span class="co">## 3 parent 1 93.50</span></span> -<span><span class="co">## 4 parent 1 92.50</span></span> -<span><span class="co">## 5 parent 3 63.23</span></span> -<span><span class="co">## 6 parent 3 68.99</span></span> -<span><span class="co">## 7 parent 7 52.32</span></span> -<span><span class="co">## 8 parent 7 55.13</span></span> -<span><span class="co">## 9 parent 14 27.27</span></span> -<span><span class="co">## 10 parent 14 26.64</span></span> -<span><span class="co">## 11 parent 21 11.50</span></span> -<span><span class="co">## 12 parent 21 11.64</span></span> -<span><span class="co">## 13 parent 35 2.85</span></span> -<span><span class="co">## 14 parent 35 2.91</span></span> -<span><span class="co">## 15 parent 50 0.69</span></span> -<span><span class="co">## 16 parent 50 0.63</span></span> -<span><span class="co">## 17 parent 75 0.05</span></span> -<span><span class="co">## 18 parent 75 0.06</span></span> -<span><span class="co">## 19 parent 100 NA</span></span> -<span><span class="co">## 20 parent 100 NA</span></span> -<span><span class="co">## 21 parent 120 NA</span></span> -<span><span class="co">## 22 parent 120 NA</span></span> -<span><span class="co">## 23 m1 0 0.00</span></span> -<span><span class="co">## 24 m1 0 0.00</span></span> -<span><span class="co">## 25 m1 1 4.84</span></span> -<span><span class="co">## 26 m1 1 5.64</span></span> -<span><span class="co">## 27 m1 3 12.91</span></span> -<span><span class="co">## 28 m1 3 12.96</span></span> -<span><span class="co">## 29 m1 7 22.97</span></span> -<span><span class="co">## 30 m1 7 24.47</span></span> -<span><span class="co">## 31 m1 14 41.69</span></span> -<span><span class="co">## 32 m1 14 33.21</span></span> -<span><span class="co">## 33 m1 21 44.37</span></span> -<span><span class="co">## 34 m1 21 46.44</span></span> -<span><span class="co">## 35 m1 35 41.22</span></span> -<span><span class="co">## 36 m1 35 37.95</span></span> -<span><span class="co">## 37 m1 50 41.19</span></span> -<span><span class="co">## 38 m1 50 40.01</span></span> -<span><span class="co">## 39 m1 75 40.09</span></span> -<span><span class="co">## 40 m1 75 33.85</span></span> -<span><span class="co">## 41 m1 100 31.04</span></span> -<span><span class="co">## 42 m1 100 33.13</span></span> -<span><span class="co">## 43 m1 120 25.15</span></span> -<span><span class="co">## 44 m1 120 33.31</span></span></code></pre> -<p>Next we specify the degradation model: The parent compound degrades -with simple first-order kinetics (SFO) to one metabolite named m1, which -also degrades with SFO kinetics.</p> -<p>The call to mkinmod returns a degradation model. The differential -equations represented in R code can be found in the character vector -<code>$diffs</code> of the <code>mkinmod</code> object. If a C compiler -(gcc) is installed and functional, the differential equation model will -be compiled from auto-generated C code.</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">SFO_SFO</span><span class="op">$</span><span class="va">diffs</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## parent </span></span> -<span><span class="co">## "d_parent = - k_parent * parent" </span></span> -<span><span class="co">## m1 </span></span> -<span><span class="co">## "d_m1 = + f_parent_to_m1 * k_parent * parent - k_m1 * m1"</span></span></code></pre> -<p>We do the fitting without progress report -(<code>quiet = TRUE</code>).</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(SFO_SFO, FOCUS_2006_D, quiet = TRUE): Observations with</span></span> -<span><span class="co">## value of zero were removed from the data</span></span></code></pre> -<p>A plot of the fit including a residual plot for both observed -variables is obtained using the <code>plot_sep</code> method for -<code>mkinfit</code> objects, which shows separate graphs for all -compounds and their residuals.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_D_files/figure-html/plot-1.png" width="768"></p> -<p>Confidence intervals for the parameter estimates are obtained using -the <code>mkinparplot</code> function.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/mkinparplot.html">mkinparplot</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_D_files/figure-html/plot_2-1.png" width="768"></p> -<p>A comprehensive report of the results is obtained using the -<code>summary</code> method for <code>mkinfit</code> objects.</p> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:12 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:12 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - k_parent * parent</span></span> -<span><span class="co">## d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 401 model solutions performed in 0.05 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 100.7500 state</span></span> -<span><span class="co">## k_parent 0.1000 deparm</span></span> -<span><span class="co">## k_m1 0.1001 deparm</span></span> -<span><span class="co">## f_parent_to_m1 0.5000 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 100.750000 -Inf Inf</span></span> -<span><span class="co">## log_k_parent -2.302585 -Inf Inf</span></span> -<span><span class="co">## log_k_m1 -2.301586 -Inf Inf</span></span> -<span><span class="co">## f_parent_qlogis 0.000000 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## m1_0 0 state</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Warning(s): </span></span> -<span><span class="co">## Observations with value of zero were removed from the data</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 204.4486 212.6365 -97.22429</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 99.60000 1.57000 96.4000 102.8000</span></span> -<span><span class="co">## log_k_parent -2.31600 0.04087 -2.3990 -2.2330</span></span> -<span><span class="co">## log_k_m1 -5.24700 0.13320 -5.5180 -4.9770</span></span> -<span><span class="co">## f_parent_qlogis 0.05792 0.08926 -0.1237 0.2395</span></span> -<span><span class="co">## sigma 3.12600 0.35850 2.3960 3.8550</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_k_parent log_k_m1 f_parent_qlogis sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 5.174e-01 -1.688e-01 -5.471e-01 -1.172e-06</span></span> -<span><span class="co">## log_k_parent 5.174e-01 1.000e+00 -3.263e-01 -5.426e-01 -8.483e-07</span></span> -<span><span class="co">## log_k_m1 -1.688e-01 -3.263e-01 1.000e+00 7.478e-01 8.205e-07</span></span> -<span><span class="co">## f_parent_qlogis -5.471e-01 -5.426e-01 7.478e-01 1.000e+00 1.305e-06</span></span> -<span><span class="co">## sigma -1.172e-06 -8.483e-07 8.205e-07 1.305e-06 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 99.600000 63.430 2.298e-36 96.400000 1.028e+02</span></span> -<span><span class="co">## k_parent 0.098700 24.470 4.955e-23 0.090820 1.073e-01</span></span> -<span><span class="co">## k_m1 0.005261 7.510 6.165e-09 0.004012 6.898e-03</span></span> -<span><span class="co">## f_parent_to_m1 0.514500 23.070 3.104e-22 0.469100 5.596e-01</span></span> -<span><span class="co">## sigma 3.126000 8.718 2.235e-10 2.396000 3.855e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 6.398 4 15</span></span> -<span><span class="co">## parent 6.459 2 7</span></span> -<span><span class="co">## m1 4.690 2 8</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Resulting formation fractions:</span></span> -<span><span class="co">## ff</span></span> -<span><span class="co">## parent_m1 0.5145</span></span> -<span><span class="co">## parent_sink 0.4855</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90</span></span> -<span><span class="co">## parent 7.023 23.33</span></span> -<span><span class="co">## m1 131.761 437.70</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Data:</span></span> -<span><span class="co">## time variable observed predicted residual</span></span> -<span><span class="co">## 0 parent 99.46 99.59848 -1.385e-01</span></span> -<span><span class="co">## 0 parent 102.04 99.59848 2.442e+00</span></span> -<span><span class="co">## 1 parent 93.50 90.23787 3.262e+00</span></span> -<span><span class="co">## 1 parent 92.50 90.23787 2.262e+00</span></span> -<span><span class="co">## 3 parent 63.23 74.07319 -1.084e+01</span></span> -<span><span class="co">## 3 parent 68.99 74.07319 -5.083e+00</span></span> -<span><span class="co">## 7 parent 52.32 49.91207 2.408e+00</span></span> -<span><span class="co">## 7 parent 55.13 49.91207 5.218e+00</span></span> -<span><span class="co">## 14 parent 27.27 25.01258 2.257e+00</span></span> -<span><span class="co">## 14 parent 26.64 25.01258 1.627e+00</span></span> -<span><span class="co">## 21 parent 11.50 12.53462 -1.035e+00</span></span> -<span><span class="co">## 21 parent 11.64 12.53462 -8.946e-01</span></span> -<span><span class="co">## 35 parent 2.85 3.14787 -2.979e-01</span></span> -<span><span class="co">## 35 parent 2.91 3.14787 -2.379e-01</span></span> -<span><span class="co">## 50 parent 0.69 0.71624 -2.624e-02</span></span> -<span><span class="co">## 50 parent 0.63 0.71624 -8.624e-02</span></span> -<span><span class="co">## 75 parent 0.05 0.06074 -1.074e-02</span></span> -<span><span class="co">## 75 parent 0.06 0.06074 -7.382e-04</span></span> -<span><span class="co">## 1 m1 4.84 4.80296 3.704e-02</span></span> -<span><span class="co">## 1 m1 5.64 4.80296 8.370e-01</span></span> -<span><span class="co">## 3 m1 12.91 13.02400 -1.140e-01</span></span> -<span><span class="co">## 3 m1 12.96 13.02400 -6.400e-02</span></span> -<span><span class="co">## 7 m1 22.97 25.04476 -2.075e+00</span></span> -<span><span class="co">## 7 m1 24.47 25.04476 -5.748e-01</span></span> -<span><span class="co">## 14 m1 41.69 36.69003 5.000e+00</span></span> -<span><span class="co">## 14 m1 33.21 36.69003 -3.480e+00</span></span> -<span><span class="co">## 21 m1 44.37 41.65310 2.717e+00</span></span> -<span><span class="co">## 21 m1 46.44 41.65310 4.787e+00</span></span> -<span><span class="co">## 35 m1 41.22 43.31313 -2.093e+00</span></span> -<span><span class="co">## 35 m1 37.95 43.31313 -5.363e+00</span></span> -<span><span class="co">## 50 m1 41.19 41.21832 -2.832e-02</span></span> -<span><span class="co">## 50 m1 40.01 41.21832 -1.208e+00</span></span> -<span><span class="co">## 75 m1 40.09 36.44704 3.643e+00</span></span> -<span><span class="co">## 75 m1 33.85 36.44704 -2.597e+00</span></span> -<span><span class="co">## 100 m1 31.04 31.98162 -9.416e-01</span></span> -<span><span class="co">## 100 m1 33.13 31.98162 1.148e+00</span></span> -<span><span class="co">## 120 m1 25.15 28.78984 -3.640e+00</span></span> -<span><span class="co">## 120 m1 33.31 28.78984 4.520e+00</span></span></code></pre> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - </div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/FOCUS_D_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/FOCUS_D_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/FOCUS_D_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) --> -// 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</li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Example evaluation of FOCUS Laboratory Data L1 -to L3</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 18 May 2022 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/FOCUS_L.rmd" class="external-link"><code>vignettes/FOCUS_L.rmd</code></a></small> - <div class="hidden name"><code>FOCUS_L.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="laboratory-data-l1">Laboratory Data L1<a class="anchor" aria-label="anchor" href="#laboratory-data-l1"></a> -</h2> -<p>The following code defines example dataset L1 from the FOCUS kinetics -report, p. 284:</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">FOCUS_2006_L1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">5</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">21</span>, <span class="fl">30</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>,</span> -<span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">88.3</span>, <span class="fl">91.4</span>, <span class="fl">85.6</span>, <span class="fl">84.5</span>, <span class="fl">78.9</span>, <span class="fl">77.6</span>,</span> -<span> <span class="fl">72.0</span>, <span class="fl">71.9</span>, <span class="fl">50.3</span>, <span class="fl">59.4</span>, <span class="fl">47.0</span>, <span class="fl">45.1</span>,</span> -<span> <span class="fl">27.7</span>, <span class="fl">27.3</span>, <span class="fl">10.0</span>, <span class="fl">10.4</span>, <span class="fl">2.9</span>, <span class="fl">4.0</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">FOCUS_2006_L1_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L1</span><span class="op">)</span></span></code></pre></div> -<p>Here we use the assumptions of simple first order (SFO), the case of -declining rate constant over time (FOMC) and the case of two different -phases of the kinetics (DFOP). For a more detailed discussion of the -models, please see the FOCUS kinetics report.</p> -<p>Since mkin version 0.9-32 (July 2014), we can use shorthand notation -like <code>"SFO"</code> for parent only degradation models. The -following two lines fit the model and produce the summary report of the -model fit. This covers the numerical analysis given in the FOCUS -report.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.L1.SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_L1_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.SFO</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - k_parent * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 133 model solutions performed in 0.011 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 89.85 state</span></span> -<span><span class="co">## k_parent 0.10 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 89.850000 -Inf Inf</span></span> -<span><span class="co">## log_k_parent -2.302585 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 93.88778 96.5589 -43.94389</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 92.470 1.28200 89.740 95.200</span></span> -<span><span class="co">## log_k_parent -2.347 0.03763 -2.428 -2.267</span></span> -<span><span class="co">## sigma 2.780 0.46330 1.792 3.767</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_k_parent sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 6.186e-01 -1.516e-09</span></span> -<span><span class="co">## log_k_parent 6.186e-01 1.000e+00 -3.124e-09</span></span> -<span><span class="co">## sigma -1.516e-09 -3.124e-09 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 92.47000 72.13 8.824e-21 89.74000 95.2000</span></span> -<span><span class="co">## k_parent 0.09561 26.57 2.487e-14 0.08824 0.1036</span></span> -<span><span class="co">## sigma 2.78000 6.00 1.216e-05 1.79200 3.7670</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 3.424 2 7</span></span> -<span><span class="co">## parent 3.424 2 7</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90</span></span> -<span><span class="co">## parent 7.249 24.08</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Data:</span></span> -<span><span class="co">## time variable observed predicted residual</span></span> -<span><span class="co">## 0 parent 88.3 92.471 -4.1710</span></span> -<span><span class="co">## 0 parent 91.4 92.471 -1.0710</span></span> -<span><span class="co">## 1 parent 85.6 84.039 1.5610</span></span> -<span><span class="co">## 1 parent 84.5 84.039 0.4610</span></span> -<span><span class="co">## 2 parent 78.9 76.376 2.5241</span></span> -<span><span class="co">## 2 parent 77.6 76.376 1.2241</span></span> -<span><span class="co">## 3 parent 72.0 69.412 2.5884</span></span> -<span><span class="co">## 3 parent 71.9 69.412 2.4884</span></span> -<span><span class="co">## 5 parent 50.3 57.330 -7.0301</span></span> -<span><span class="co">## 5 parent 59.4 57.330 2.0699</span></span> -<span><span class="co">## 7 parent 47.0 47.352 -0.3515</span></span> -<span><span class="co">## 7 parent 45.1 47.352 -2.2515</span></span> -<span><span class="co">## 14 parent 27.7 24.247 3.4528</span></span> -<span><span class="co">## 14 parent 27.3 24.247 3.0528</span></span> -<span><span class="co">## 21 parent 10.0 12.416 -2.4163</span></span> -<span><span class="co">## 21 parent 10.4 12.416 -2.0163</span></span> -<span><span class="co">## 30 parent 2.9 5.251 -2.3513</span></span> -<span><span class="co">## 30 parent 4.0 5.251 -1.2513</span></span></code></pre> -<p>A plot of the fit is obtained with the plot function for mkinfit -objects.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L1.SFO</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - SFO"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-4-1.png" width="576"></p> -<p>The residual plot can be easily obtained by</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../reference/mkinresplot.html">mkinresplot</a></span><span class="op">(</span><span class="va">m.L1.SFO</span>, ylab <span class="op">=</span> <span class="st">"Observed"</span>, xlab <span class="op">=</span> <span class="st">"Time"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-5-1.png" width="576"></p> -<p>For comparison, the FOMC model is fitted as well, and the <span class="math inline">\(\chi^2\)</span> error level is checked.</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.L1.FOMC</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_L1_mkin</span>, quiet<span class="op">=</span><span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit("FOMC", FOCUS_2006_L1_mkin, quiet = TRUE): Optimisation did not converge:</span></span> -<span><span class="co">## false convergence (8)</span></span></code></pre> -<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>, main <span class="op">=</span> <span class="st">"FOCUS L1 - FOMC"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-6-1.png" width="576"></p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L1.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 369 model solutions performed in 0.025 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 89.85 state</span></span> -<span><span class="co">## alpha 1.00 deparm</span></span> -<span><span class="co">## beta 10.00 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 89.850000 -Inf Inf</span></span> -<span><span class="co">## log_alpha 0.000000 -Inf Inf</span></span> -<span><span class="co">## log_beta 2.302585 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Warning(s): </span></span> -<span><span class="co">## Optimisation did not converge:</span></span> -<span><span class="co">## false convergence (8)</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 95.88781 99.44929 -43.9439</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 92.47 1.2820 89.720 95.220</span></span> -<span><span class="co">## log_alpha 13.78 NaN NaN NaN</span></span> -<span><span class="co">## log_beta 16.13 NaN NaN NaN</span></span> -<span><span class="co">## sigma 2.78 0.4598 1.794 3.766</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_alpha log_beta sigma</span></span> -<span><span class="co">## parent_0 1.0000000 NaN NaN 0.0001671</span></span> -<span><span class="co">## log_alpha NaN 1 NaN NaN</span></span> -<span><span class="co">## log_beta NaN NaN 1 NaN</span></span> -<span><span class="co">## sigma 0.0001671 NaN NaN 1.0000000</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.247e+01 NA NA 89.720 95.220</span></span> -<span><span class="co">## alpha 9.658e+05 NA NA NA NA</span></span> -<span><span class="co">## beta 1.010e+07 NA NA NA NA</span></span> -<span><span class="co">## sigma 2.780e+00 NA NA 1.794 3.766</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 3.619 3 6</span></span> -<span><span class="co">## parent 3.619 3 6</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90 DT50back</span></span> -<span><span class="co">## parent 7.25 24.08 7.25</span></span></code></pre> -<p>We get a warning that the default optimisation algorithm -<code>Port</code> did not converge, which is an indication that the -model is overparameterised, <em>i.e.</em> contains too many parameters -that are ill-defined as a consequence.</p> -<p>And in fact, due to the higher number of parameters, and the lower -number of degrees of freedom of the fit, the <span class="math inline">\(\chi^2\)</span> error level is actually higher for -the FOMC model (3.6%) than for the SFO model (3.4%). Additionally, the -parameters <code>log_alpha</code> and <code>log_beta</code> internally -fitted in the model have excessive confidence intervals, that span more -than 25 orders of magnitude (!) when backtransformed to the scale of -<code>alpha</code> and <code>beta</code>. Also, the t-test for -significant difference from zero does not indicate such a significant -difference, with p-values greater than 0.1, and finally, the parameter -correlation of <code>log_alpha</code> and <code>log_beta</code> is -1.000, clearly indicating that the model is overparameterised.</p> -<p>The <span class="math inline">\(\chi^2\)</span> error levels reported -in Appendix 3 and Appendix 7 to the FOCUS kinetics report are rounded to -integer percentages and partly deviate by one percentage point from the -results calculated by mkin. The reason for this is not known. However, -mkin gives the same <span class="math inline">\(\chi^2\)</span> error -levels as the kinfit package and the calculation routines of the kinfit -package have been extensively compared to the results obtained by the -KinGUI software, as documented in the kinfit package vignette. KinGUI -was the first widely used standard package in this field. Also, the -calculation of <span class="math inline">\(\chi^2\)</span> error levels -was compared with KinGUII, CAKE and DegKin manager in a project -sponsored by the German Umweltbundesamt <span class="citation">(Ranke -2014)</span>.</p> -</div> -<div class="section level2"> -<h2 id="laboratory-data-l2">Laboratory Data L2<a class="anchor" aria-label="anchor" href="#laboratory-data-l2"></a> -</h2> -<p>The following code defines example dataset L2 from the FOCUS kinetics -report, p. 287:</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">FOCUS_2006_L2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span><span class="op">)</span>, each <span class="op">=</span> <span class="fl">2</span><span class="op">)</span>,</span> -<span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">96.1</span>, <span class="fl">91.8</span>, <span class="fl">41.4</span>, <span class="fl">38.7</span>,</span> -<span> <span class="fl">19.3</span>, <span class="fl">22.3</span>, <span class="fl">4.6</span>, <span class="fl">4.6</span>,</span> -<span> <span class="fl">2.6</span>, <span class="fl">1.2</span>, <span class="fl">0.3</span>, <span class="fl">0.6</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">FOCUS_2006_L2_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L2</span><span class="op">)</span></span></code></pre></div> -<div class="section level3"> -<h3 id="sfo-fit-for-l2">SFO fit for L2<a class="anchor" aria-label="anchor" href="#sfo-fit-for-l2"></a> -</h3> -<p>Again, the SFO model is fitted and the result is plotted. The -residual plot can be obtained simply by adding the argument -<code>show_residuals</code> to the plot command.</p> -<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.L2.SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet<span class="op">=</span><span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.SFO</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> main <span class="op">=</span> <span class="st">"FOCUS L2 - SFO"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-8-1.png" width="672"></p> -<p>The <span class="math inline">\(\chi^2\)</span> error level of 14% -suggests that the model does not fit very well. This is also obvious -from the plots of the fit, in which we have included the residual -plot.</p> -<p>In the FOCUS kinetics report, it is stated that there is no apparent -systematic error observed from the residual plot up to the measured DT90 -(approximately at day 5), and there is an underestimation beyond that -point.</p> -<p>We may add that it is difficult to judge the random nature of the -residuals just from the three samplings at days 0, 1 and 3. Also, it is -not clear <em>a priori</em> why a consistent underestimation after the -approximate DT90 should be irrelevant. However, this can be rationalised -by the fact that the FOCUS fate models generally only implement SFO -kinetics.</p> -</div> -<div class="section level3"> -<h3 id="fomc-fit-for-l2">FOMC fit for L2<a class="anchor" aria-label="anchor" href="#fomc-fit-for-l2"></a> -</h3> -<p>For comparison, the FOMC model is fitted as well, and the <span class="math inline">\(\chi^2\)</span> error level is checked.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.L2.FOMC</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> main <span class="op">=</span> <span class="st">"FOCUS L2 - FOMC"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-9-1.png" width="672"></p> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.FOMC</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:14 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 239 model solutions performed in 0.015 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 93.95 state</span></span> -<span><span class="co">## alpha 1.00 deparm</span></span> -<span><span class="co">## beta 10.00 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 93.950000 -Inf Inf</span></span> -<span><span class="co">## log_alpha 0.000000 -Inf Inf</span></span> -<span><span class="co">## log_beta 2.302585 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 61.78966 63.72928 -26.89483</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 93.7700 1.6130 90.05000 97.4900</span></span> -<span><span class="co">## log_alpha 0.3180 0.1559 -0.04149 0.6776</span></span> -<span><span class="co">## log_beta 0.2102 0.2493 -0.36460 0.7850</span></span> -<span><span class="co">## sigma 2.2760 0.4645 1.20500 3.3470</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_alpha log_beta sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 -1.151e-01 -2.085e-01 -7.828e-09</span></span> -<span><span class="co">## log_alpha -1.151e-01 1.000e+00 9.741e-01 -1.602e-07</span></span> -<span><span class="co">## log_beta -2.085e-01 9.741e-01 1.000e+00 -1.372e-07</span></span> -<span><span class="co">## sigma -7.828e-09 -1.602e-07 -1.372e-07 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 93.770 58.120 4.267e-12 90.0500 97.490</span></span> -<span><span class="co">## alpha 1.374 6.414 1.030e-04 0.9594 1.969</span></span> -<span><span class="co">## beta 1.234 4.012 1.942e-03 0.6945 2.192</span></span> -<span><span class="co">## sigma 2.276 4.899 5.977e-04 1.2050 3.347</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 6.205 3 3</span></span> -<span><span class="co">## parent 6.205 3 3</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90 DT50back</span></span> -<span><span class="co">## parent 0.8092 5.356 1.612</span></span></code></pre> -<p>The error level at which the <span class="math inline">\(\chi^2\)</span> test passes is much lower in this -case. Therefore, the FOMC model provides a better description of the -data, as less experimental error has to be assumed in order to explain -the data.</p> -</div> -<div class="section level3"> -<h3 id="dfop-fit-for-l2">DFOP fit for L2<a class="anchor" aria-label="anchor" href="#dfop-fit-for-l2"></a> -</h3> -<p>Fitting the four parameter DFOP model further reduces the <span class="math inline">\(\chi^2\)</span> error level.</p> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.L2.DFOP</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_L2_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> main <span class="op">=</span> <span class="st">"FOCUS L2 - DFOP"</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-10-1.png" width="672"></p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.L2.DFOP</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span></span> -<span><span class="co">## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span></span> -<span><span class="co">## * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 581 model solutions performed in 0.04 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 93.95 state</span></span> -<span><span class="co">## k1 0.10 deparm</span></span> -<span><span class="co">## k2 0.01 deparm</span></span> -<span><span class="co">## g 0.50 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 93.950000 -Inf Inf</span></span> -<span><span class="co">## log_k1 -2.302585 -Inf Inf</span></span> -<span><span class="co">## log_k2 -4.605170 -Inf Inf</span></span> -<span><span class="co">## g_qlogis 0.000000 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 52.36695 54.79148 -21.18347</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 93.950 9.998e-01 91.5900 96.3100</span></span> -<span><span class="co">## log_k1 3.112 1.842e+03 -4353.0000 4359.0000</span></span> -<span><span class="co">## log_k2 -1.088 6.285e-02 -1.2370 -0.9394</span></span> -<span><span class="co">## g_qlogis -0.399 9.946e-02 -0.6342 -0.1638</span></span> -<span><span class="co">## sigma 1.414 2.886e-01 0.7314 2.0960</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_k1 log_k2 g_qlogis sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 6.783e-07 -3.390e-10 2.665e-01 -2.967e-10</span></span> -<span><span class="co">## log_k1 6.783e-07 1.000e+00 1.116e-04 -2.196e-04 -1.031e-05</span></span> -<span><span class="co">## log_k2 -3.390e-10 1.116e-04 1.000e+00 -7.903e-01 2.917e-09</span></span> -<span><span class="co">## g_qlogis 2.665e-01 -2.196e-04 -7.903e-01 1.000e+00 -4.408e-09</span></span> -<span><span class="co">## sigma -2.967e-10 -1.031e-05 2.917e-09 -4.408e-09 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 93.9500 9.397e+01 2.036e-12 91.5900 96.3100</span></span> -<span><span class="co">## k1 22.4800 5.553e-04 4.998e-01 0.0000 Inf</span></span> -<span><span class="co">## k2 0.3369 1.591e+01 4.697e-07 0.2904 0.3909</span></span> -<span><span class="co">## g 0.4016 1.680e+01 3.238e-07 0.3466 0.4591</span></span> -<span><span class="co">## sigma 1.4140 4.899e+00 8.776e-04 0.7314 2.0960</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 2.53 4 2</span></span> -<span><span class="co">## parent 2.53 4 2</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90 DT50back DT50_k1 DT50_k2</span></span> -<span><span class="co">## parent 0.5335 5.311 1.599 0.03084 2.058</span></span></code></pre> -<p>Here, the DFOP model is clearly the best-fit model for dataset L2 -based on the chi^2 error level criterion.</p> -</div> -</div> -<div class="section level2"> -<h2 id="laboratory-data-l3">Laboratory Data L3<a class="anchor" aria-label="anchor" href="#laboratory-data-l3"></a> -</h2> -<p>The following code defines example dataset L3 from the FOCUS kinetics -report, p. 290.</p> -<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">FOCUS_2006_L3</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>,</span> -<span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">97.8</span>, <span class="fl">60</span>, <span class="fl">51</span>, <span class="fl">43</span>, <span class="fl">35</span>, <span class="fl">22</span>, <span class="fl">15</span>, <span class="fl">12</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">FOCUS_2006_L3_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L3</span><span class="op">)</span></span></code></pre></div> -<div class="section level3"> -<h3 id="fit-multiple-models">Fit multiple models<a class="anchor" aria-label="anchor" href="#fit-multiple-models"></a> -</h3> -<p>As of mkin version 0.9-39 (June 2015), we can fit several models to -one or more datasets in one call to the function <code>mmkin</code>. The -datasets have to be passed in a list, in this case a named list holding -only the L3 dataset prepared above.</p> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="co"># Only use one core here, not to offend the CRAN checks</span></span> -<span><span class="va">mm.L3</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>,</span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS L3"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L3_mkin</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-12-1.png" width="700"></p> -<p>The <span class="math inline">\(\chi^2\)</span> error level of 21% as -well as the plot suggest that the SFO model does not fit very well. The -FOMC model performs better, with an error level at which the <span class="math inline">\(\chi^2\)</span> test passes of 7%. Fitting the -four parameter DFOP model further reduces the <span class="math inline">\(\chi^2\)</span> error level considerably.</p> -</div> -<div class="section level3"> -<h3 id="accessing-mmkin-objects">Accessing mmkin objects<a class="anchor" aria-label="anchor" href="#accessing-mmkin-objects"></a> -</h3> -<p>The objects returned by mmkin are arranged like a matrix, with models -as a row index and datasets as a column index.</p> -<p>We can extract the summary and plot for <em>e.g.</em> the DFOP fit, -using square brackets for indexing which will result in the use of the -summary and plot functions working on mkinfit objects.</p> -<div class="sourceCode" id="cb24"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span></span> -<span><span class="co">## time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span></span> -<span><span class="co">## * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 376 model solutions performed in 0.024 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 97.80 state</span></span> -<span><span class="co">## k1 0.10 deparm</span></span> -<span><span class="co">## k2 0.01 deparm</span></span> -<span><span class="co">## g 0.50 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 97.800000 -Inf Inf</span></span> -<span><span class="co">## log_k1 -2.302585 -Inf Inf</span></span> -<span><span class="co">## log_k2 -4.605170 -Inf Inf</span></span> -<span><span class="co">## g_qlogis 0.000000 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 32.97732 33.37453 -11.48866</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 97.7500 1.01900 94.5000 101.000000</span></span> -<span><span class="co">## log_k1 -0.6612 0.10050 -0.9812 -0.341300</span></span> -<span><span class="co">## log_k2 -4.2860 0.04322 -4.4230 -4.148000</span></span> -<span><span class="co">## g_qlogis -0.1739 0.05270 -0.3416 -0.006142</span></span> -<span><span class="co">## sigma 1.0170 0.25430 0.2079 1.827000</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_k1 log_k2 g_qlogis sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 1.732e-01 2.282e-02 4.009e-01 -9.664e-08</span></span> -<span><span class="co">## log_k1 1.732e-01 1.000e+00 4.945e-01 -5.809e-01 7.147e-07</span></span> -<span><span class="co">## log_k2 2.282e-02 4.945e-01 1.000e+00 -6.812e-01 1.022e-06</span></span> -<span><span class="co">## g_qlogis 4.009e-01 -5.809e-01 -6.812e-01 1.000e+00 -7.926e-07</span></span> -<span><span class="co">## sigma -9.664e-08 7.147e-07 1.022e-06 -7.926e-07 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.75000 95.960 1.248e-06 94.50000 101.00000</span></span> -<span><span class="co">## k1 0.51620 9.947 1.081e-03 0.37490 0.71090</span></span> -<span><span class="co">## k2 0.01376 23.140 8.840e-05 0.01199 0.01579</span></span> -<span><span class="co">## g 0.45660 34.920 2.581e-05 0.41540 0.49850</span></span> -<span><span class="co">## sigma 1.01700 4.000 1.400e-02 0.20790 1.82700</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 2.225 4 4</span></span> -<span><span class="co">## parent 2.225 4 4</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90 DT50back DT50_k1 DT50_k2</span></span> -<span><span class="co">## parent 7.464 123 37.03 1.343 50.37</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Data:</span></span> -<span><span class="co">## time variable observed predicted residual</span></span> -<span><span class="co">## 0 parent 97.8 97.75 0.05396</span></span> -<span><span class="co">## 3 parent 60.0 60.45 -0.44933</span></span> -<span><span class="co">## 7 parent 51.0 49.44 1.56338</span></span> -<span><span class="co">## 14 parent 43.0 43.84 -0.83632</span></span> -<span><span class="co">## 30 parent 35.0 35.15 -0.14707</span></span> -<span><span class="co">## 60 parent 22.0 23.26 -1.25919</span></span> -<span><span class="co">## 91 parent 15.0 15.18 -0.18181</span></span> -<span><span class="co">## 120 parent 12.0 10.19 1.81395</span></span></code></pre> -<div class="sourceCode" id="cb26"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L3</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-13-1.png" width="700"></p> -<p>Here, a look to the model plot, the confidence intervals of the -parameters and the correlation matrix suggest that the parameter -estimates are reliable, and the DFOP model can be used as the best-fit -model based on the <span class="math inline">\(\chi^2\)</span> error -level criterion for laboratory data L3.</p> -<p>This is also an example where the standard t-test for the parameter -<code>g_ilr</code> is misleading, as it tests for a significant -difference from zero. In this case, zero appears to be the correct value -for this parameter, and the confidence interval for the backtransformed -parameter <code>g</code> is quite narrow.</p> -</div> -</div> -<div class="section level2"> -<h2 id="laboratory-data-l4">Laboratory Data L4<a class="anchor" aria-label="anchor" href="#laboratory-data-l4"></a> -</h2> -<p>The following code defines example dataset L4 from the FOCUS kinetics -report, p. 293:</p> -<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">FOCUS_2006_L4</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">30</span>, <span class="fl">60</span>, <span class="fl">91</span>, <span class="fl">120</span><span class="op">)</span>,</span> -<span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">96.6</span>, <span class="fl">96.3</span>, <span class="fl">94.3</span>, <span class="fl">88.8</span>, <span class="fl">74.9</span>, <span class="fl">59.9</span>, <span class="fl">53.5</span>, <span class="fl">49.0</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">FOCUS_2006_L4_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_L4</span><span class="op">)</span></span></code></pre></div> -<p>Fits of the SFO and FOMC models, plots and summaries are produced -below:</p> -<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="co"># Only use one core here, not to offend the CRAN checks</span></span> -<span><span class="va">mm.L4</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>,</span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS L4"</span> <span class="op">=</span> <span class="va">FOCUS_2006_L4_mkin</span><span class="op">)</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_L_files/figure-html/unnamed-chunk-15-1.png" width="700"></p> -<p>The <span class="math inline">\(\chi^2\)</span> error level of 3.3% -as well as the plot suggest that the SFO model fits very well. The error -level at which the <span class="math inline">\(\chi^2\)</span> test -passes is slightly lower for the FOMC model. However, the difference -appears negligible.</p> -<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:16 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - k_parent * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 142 model solutions performed in 0.009 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 96.6 state</span></span> -<span><span class="co">## k_parent 0.1 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 96.600000 -Inf Inf</span></span> -<span><span class="co">## log_k_parent -2.302585 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 47.12133 47.35966 -20.56067</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 96.440 1.69900 92.070 100.800</span></span> -<span><span class="co">## log_k_parent -5.030 0.07059 -5.211 -4.848</span></span> -<span><span class="co">## sigma 3.162 0.79050 1.130 5.194</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_k_parent sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 5.938e-01 3.387e-07</span></span> -<span><span class="co">## log_k_parent 5.938e-01 1.000e+00 5.830e-07</span></span> -<span><span class="co">## sigma 3.387e-07 5.830e-07 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.440000 56.77 1.604e-08 92.070000 1.008e+02</span></span> -<span><span class="co">## k_parent 0.006541 14.17 1.578e-05 0.005455 7.842e-03</span></span> -<span><span class="co">## sigma 3.162000 4.00 5.162e-03 1.130000 5.194e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 3.287 2 6</span></span> -<span><span class="co">## parent 3.287 2 6</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90</span></span> -<span><span class="co">## parent 106 352</span></span></code></pre> -<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">mm.L4</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## mkin version used for fitting: 1.2.3 </span></span> -<span><span class="co">## R version used for fitting: 4.2.3 </span></span> -<span><span class="co">## Date of fit: Sun Apr 16 08:35:15 2023 </span></span> -<span><span class="co">## Date of summary: Sun Apr 16 08:35:16 2023 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Equations:</span></span> -<span><span class="co">## d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Model predictions using solution type analytical </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fitted using 224 model solutions performed in 0.014 s</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model: Constant variance </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Error model algorithm: OLS </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for parameters to be optimised:</span></span> -<span><span class="co">## value type</span></span> -<span><span class="co">## parent_0 96.6 state</span></span> -<span><span class="co">## alpha 1.0 deparm</span></span> -<span><span class="co">## beta 10.0 deparm</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Starting values for the transformed parameters actually optimised:</span></span> -<span><span class="co">## value lower upper</span></span> -<span><span class="co">## parent_0 96.600000 -Inf Inf</span></span> -<span><span class="co">## log_alpha 0.000000 -Inf Inf</span></span> -<span><span class="co">## log_beta 2.302585 -Inf Inf</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Fixed parameter values:</span></span> -<span><span class="co">## None</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Results:</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## AIC BIC logLik</span></span> -<span><span class="co">## 40.37255 40.69032 -16.18628</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Optimised, transformed parameters with symmetric confidence intervals:</span></span> -<span><span class="co">## Estimate Std. Error Lower Upper</span></span> -<span><span class="co">## parent_0 99.1400 1.2670 95.6300 102.7000</span></span> -<span><span class="co">## log_alpha -0.3506 0.2616 -1.0770 0.3756</span></span> -<span><span class="co">## log_beta 4.1740 0.3938 3.0810 5.2670</span></span> -<span><span class="co">## sigma 1.8300 0.4575 0.5598 3.1000</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameter correlation:</span></span> -<span><span class="co">## parent_0 log_alpha log_beta sigma</span></span> -<span><span class="co">## parent_0 1.000e+00 -4.696e-01 -5.543e-01 -2.468e-07</span></span> -<span><span class="co">## log_alpha -4.696e-01 1.000e+00 9.889e-01 2.478e-08</span></span> -<span><span class="co">## log_beta -5.543e-01 9.889e-01 1.000e+00 5.211e-08</span></span> -<span><span class="co">## sigma -2.468e-07 2.478e-08 5.211e-08 1.000e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Backtransformed parameters:</span></span> -<span><span class="co">## Confidence intervals for internally transformed parameters are asymmetric.</span></span> -<span><span class="co">## t-test (unrealistically) based on the assumption of normal distribution</span></span> -<span><span class="co">## for estimators of untransformed parameters.</span></span> -<span><span class="co">## Estimate t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 99.1400 78.250 7.993e-08 95.6300 102.700</span></span> -<span><span class="co">## alpha 0.7042 3.823 9.365e-03 0.3407 1.456</span></span> -<span><span class="co">## beta 64.9800 2.540 3.201e-02 21.7800 193.900</span></span> -<span><span class="co">## sigma 1.8300 4.000 8.065e-03 0.5598 3.100</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## FOCUS Chi2 error levels in percent:</span></span> -<span><span class="co">## err.min n.optim df</span></span> -<span><span class="co">## All data 2.029 3 5</span></span> -<span><span class="co">## parent 2.029 3 5</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Estimated disappearance times:</span></span> -<span><span class="co">## DT50 DT90 DT50back</span></span> -<span><span class="co">## parent 108.9 1644 494.9</span></span></code></pre> -</div> -<div class="section level2"> -<h2 class="unnumbered" id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-ranke2014" class="csl-entry"> -Ranke, Johannes. 2014. <span>“<span class="nocase">Prüfung und -Validierung von Modellierungssoftware als Alternative zu ModelMaker -4.0</span>.”</span> Umweltbundesamt Projektnummer 27452. -</div> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/FOCUS_L_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/FOCUS_L_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/FOCUS_L_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) --> -// v0.0.1 -// Written by JooYoung Seo (jooyoung@psu.edu) and Atsushi Yasumoto on June 1st, 2020. - -document.addEventListener('DOMContentLoaded', function() { - const codeList = document.getElementsByClassName("sourceCode"); 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - 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<dd> - </dd><dt><a href="prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a></dt> - <dd> - </dd><dt><a href="prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a></dt> - <dd> - </dd><dt><a href="twa.html">Calculation of time weighted average concentrations with mkin</a></dt> - <dd> - </dd><dt><a href="web_only/FOCUS_Z.html">Example evaluation of FOCUS dataset Z</a></dt> - <dd> - </dd><dt><a href="web_only/NAFTA_examples.html">Evaluation of example datasets from Attachment 1 to the US EPA SOP for the NAFTA guidance</a></dt> - <dd> - </dd><dt><a href="web_only/benchmarks.html">Benchmark timings for mkin</a></dt> - <dd> - </dd><dt><a href="web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a></dt> - <dd> - </dd><dt><a href="web_only/dimethenamid_2018.html">Example evaluations of the dimethenamid data from 2018</a></dt> - <dd> - </dd><dt><a href="web_only/multistart.html">Short demo of the multistart method</a></dt> - <dd> - </dd><dt><a href="web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a></dt> - <dd> - </dd></dl></div> - </div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/articles/mkin.html b/docs/dev/articles/mkin.html deleted file mode 100644 index fa3ac11c..00000000 --- a/docs/dev/articles/mkin.html +++ /dev/null @@ -1,472 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"> -<head> -<meta http-equiv="Content-Type" content="text/html; charset=UTF-8"> -<meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> -<title>Introduction to mkin • mkin</title> -<!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"> -<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"> -<script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"> -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"> -<!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"> -<script src="../pkgdown.js"></script><meta property="og:title" content="Introduction to mkin"> -<meta property="og:description" content="mkin"> -<meta name="robots" content="noindex"> -<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--> -</head> -<body data-spy="scroll" data-target="#toc"> - 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</li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Introduction to mkin</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 15 February 2021 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/mkin.rmd" class="external-link"><code>vignettes/mkin.rmd</code></a></small> - <div class="hidden name"><code>mkin.rmd</code></div> - - </div> - - - -<p><a href="https://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher -Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br> Privatdozent at the -University of Freiburg</p> -<div class="section level2"> -<h2 id="abstract">Abstract<a class="anchor" aria-label="anchor" href="#abstract"></a> -</h2> -<p>In the regulatory evaluation of chemical substances like plant -protection products (pesticides), biocides and other chemicals, -degradation data play an important role. For the evaluation of pesticide -degradation experiments, detailed guidance has been developed, based on -nonlinear optimisation. The <code>R</code> add-on package -<code>mkin</code> implements fitting some of the models recommended in -this guidance from within R and calculates some statistical measures for -data series within one or more compartments, for parent and -metabolites.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="co"># Define the kinetic model</span></span> -<span><span class="va">m_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span> -<span> M1 <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> -<span> M2 <span class="op">=</span> <span class="fu"><a href="../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span></span> -<span><span class="co"># Produce model predictions using some arbitrary parameters</span></span> -<span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> -<span><span class="va">d_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO_SFO_SFO</span>,</span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.03</span>,</span> -<span> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>, k_M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">100</span>,</span> -<span> f_M1_to_M2 <span class="op">=</span> <span class="fl">0.9</span>, k_M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">50</span><span class="op">)</span>,</span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> -<span> <span class="va">sampling_times</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Generate a dataset by adding normally distributed errors with</span></span> -<span><span class="co"># standard deviation 3, for two replicates at each sampling time</span></span> -<span><span class="va">d_SFO_SFO_SFO_err</span> <span class="op"><-</span> <span class="fu"><a href="../reference/add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_SFO_SFO</span>, reps <span class="op">=</span> <span class="fl">2</span>,</span> -<span> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fl">3</span>,</span> -<span> n <span class="op">=</span> <span class="fl">1</span>, seed <span class="op">=</span> <span class="fl">123456789</span> <span class="op">)</span></span> -<span></span> -<span><span class="co"># Fit the model to the dataset</span></span> -<span><span class="va">f_SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_SFO_SFO_SFO</span>, <span class="va">d_SFO_SFO_SFO_err</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Plot the results separately for parent and metabolites</span></span> -<span><span class="fu"><a href="../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_SFO_SFO_SFO</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p><img src="mkin_files/figure-html/unnamed-chunk-2-1.png" width="768"></p> -</div> -<div class="section level2"> -<h2 id="background">Background<a class="anchor" aria-label="anchor" href="#background"></a> -</h2> -<p>The <code>mkin</code> package <span class="citation">(J. Ranke -2021)</span> implements the approach to degradation kinetics recommended -in the kinetics report provided by the FOrum for Co-ordination of -pesticide fate models and their USe <span class="citation">(FOCUS Work -Group on Degradation Kinetics 2006, 2014)</span>. It covers data series -describing the decline of one compound, data series with transformation -products (commonly termed metabolites) and data series for more than one -compartment. It is possible to include back reactions. Therefore, -equilibrium reactions and equilibrium partitioning can be specified, -although this often leads to an overparameterisation of the model.</p> -<p>When the first <code>mkin</code> code was published in 2010, the most -commonly used tools for fitting more complex kinetic degradation models -to experimental data were KinGUI <span class="citation">(Schäfer et al. -2007)</span>, a MATLAB based tool with a graphical user interface that -was specifically tailored to the task and included some output as -proposed by the FOCUS Kinetics Workgroup, and ModelMaker, a general -purpose compartment based tool providing infrastructure for fitting -dynamic simulation models based on differential equations to data.</p> -<p>The ‘mkin’ code was first uploaded to the BerliOS development -platform. When this was taken down, the version control history was -imported into the R-Forge site (see <em>e.g.</em> <a href="https://cgit.jrwb.de/mkin/commit/?id=30cbb4092f6d2d3beff5800603374a0d009ad770" class="external-link">the -initial commit on 11 May 2010</a>), where the code is still being -updated.</p> -<p>At that time, the R package <code>FME</code> (Flexible Modelling -Environment) <span class="citation">(Soetaert and Petzoldt 2010)</span> -was already available, and provided a good basis for developing a -package specifically tailored to the task. The remaining challenge was -to make it as easy as possible for the users (including the author of -this vignette) to specify the system of differential equations and to -include the output requested by the FOCUS guidance, such as the <span class="math inline">\(\chi^2\)</span> error level as defined in this -guidance.</p> -<p>Also, <code>mkin</code> introduced using analytical solutions for -parent only kinetics for improved optimization speed. Later, Eigenvalue -based solutions were introduced to <code>mkin</code> for the case of -linear differential equations (<em>i.e.</em> where the FOMC or DFOP -models were not used for the parent compound), greatly improving the -optimization speed for these cases. This, has become somehow obsolete, -as the use of compiled code described below gives even faster execution -times.</p> -<p>The possibility to specify back-reactions and a biphasic model -(SFORB) for metabolites were present in <code>mkin</code> from the very -beginning.</p> -<div class="section level3"> -<h3 id="derived-software-tools">Derived software tools<a class="anchor" aria-label="anchor" href="#derived-software-tools"></a> -</h3> -<p>Soon after the publication of <code>mkin</code>, two derived tools -were published, namely KinGUII (developed at Bayer Crop Science) and -CAKE (commissioned to Tessella by Syngenta), which added a graphical -user interface (GUI), and added fitting by iteratively reweighted least -squares (IRLS) and characterisation of likely parameter distributions by -Markov Chain Monte Carlo (MCMC) sampling.</p> -<p>CAKE focuses on a smooth use experience, sacrificing some flexibility -in the model definition, originally allowing only two primary -metabolites in parallel. The current version 3.4 of CAKE released in May -2020 uses a scheme for up to six metabolites in a flexible arrangement -and supports biphasic modelling of metabolites, but does not support -back-reactions (non-instantaneous equilibria).</p> -<p>KinGUI offers an even more flexible widget for specifying complex -kinetic models. Back-reactions (non-instantaneous equilibria) were -supported early on, but until 2014, only simple first-order models could -be specified for transformation products. Starting with KinGUII version -2.1, biphasic modelling of metabolites was also available in -KinGUII.</p> -<p>A further graphical user interface (GUI) that has recently been -brought to a decent degree of maturity is the browser based GUI named -<code>gmkin</code>. Please see its <a href="https://pkgdown.jrwb.de/gmkin/" class="external-link">documentation page</a> and <a href="https://pkgdown.jrwb.de/gmkin/articles/gmkin_manual.html" class="external-link">manual</a> -for further information.</p> -<p>A comparison of scope, usability and numerical results obtained with -these tools has been recently been published by <span class="citation">Johannes Ranke, Wöltjen, and Meinecke -(2018)</span>.</p> -</div> -</div> -<div class="section level2"> -<h2 id="unique-features">Unique features<a class="anchor" aria-label="anchor" href="#unique-features"></a> -</h2> -<p>Currently, the main unique features available in <code>mkin</code> -are</p> -<ul> -<li>the <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">speed -increase</a> by using compiled code when a compiler is present,</li> -<li>parallel model fitting on multicore machines using the <a href="https://pkgdown.jrwb.de/mkin/reference/mmkin.html"><code>mmkin</code> -function</a>,</li> -<li>the estimation of parameter confidence intervals based on -transformed parameters (see below) and</li> -<li>the possibility to use the <a href="https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html">two-component -error model</a> -</li> -</ul> -<p>The iteratively reweighted least squares fitting of different -variances for each variable as introduced by <span class="citation">Gao -et al. (2011)</span> has been available in mkin since <a href="https://pkgdown.jrwb.de/mkin/news/index.html#mkin-0-9-22-2013-10-26">version -0.9-22</a>. With <a href="https://pkgdown.jrwb.de/mkin/news/index.html#mkin-0-9-49-5-2019-07-04">release -0.9.49.5</a>, the IRLS algorithm has been complemented by direct or -step-wise maximisation of the likelihood function, which makes it -possible not only to fit the variance by variable error model but also a -<a href="https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html">two-component -error model</a> inspired by error models developed in analytical -chemistry <span class="citation">(Johannes Ranke and Meinecke -2019)</span>.</p> -</div> -<div class="section level2"> -<h2 id="internal-parameter-transformations">Internal parameter transformations<a class="anchor" aria-label="anchor" href="#internal-parameter-transformations"></a> -</h2> -<p>For rate constants, the log transformation is used, as proposed by -Bates and Watts <span class="citation">(1988, 77, 149)</span>. -Approximate intervals are constructed for the transformed rate constants -<span class="citation">(compare Bates and Watts 1988, 135)</span>, -<em>i.e.</em> for their logarithms. Confidence intervals for the rate -constants are then obtained using the appropriate backtransformation -using the exponential function.</p> -<p>In the first version of <code>mkin</code> allowing for specifying -models using formation fractions, a home-made reparameterisation was -used in order to ensure that the sum of formation fractions would not -exceed unity.</p> -<p>This method is still used in the current version of KinGUII (v2.1 -from April 2014), with a modification that allows for fixing the pathway -to sink to zero. CAKE uses penalties in the objective function in order -to enforce this constraint.</p> -<p>In 2012, an alternative reparameterisation of the formation fractions -was proposed together with René Lehmann <span class="citation">(J. Ranke -and Lehmann 2012)</span>, based on isometric logratio transformation -(ILR). The aim was to improve the validity of the linear approximation -of the objective function during the parameter estimation procedure as -well as in the subsequent calculation of parameter confidence intervals. -In the current version of mkin, a logit transformation is used for -parameters that are bound between 0 and 1, such as the g parameter of -the DFOP model.</p> -<div class="section level3"> -<h3 id="confidence-intervals-based-on-transformed-parameters">Confidence intervals based on transformed parameters<a class="anchor" aria-label="anchor" href="#confidence-intervals-based-on-transformed-parameters"></a> -</h3> -<p>In the first attempt at providing improved parameter confidence -intervals introduced to <code>mkin</code> in 2013, confidence intervals -obtained from FME on the transformed parameters were simply all -backtransformed one by one to yield asymmetric confidence intervals for -the backtransformed parameters.</p> -<p>However, while there is a 1:1 relation between the rate constants in -the model and the transformed parameters fitted in the model, the -parameters obtained by the isometric logratio transformation are -calculated from the set of formation fractions that quantify the paths -to each of the compounds formed from a specific parent compound, and no -such 1:1 relation exists.</p> -<p>Therefore, parameter confidence intervals for formation fractions -obtained with this method only appear valid for the case of a single -transformation product, where currently the logit transformation is used -for the formation fraction.</p> -<p>The confidence intervals obtained by backtransformation for the cases -where a 1:1 relation between transformed and original parameter exist -are considered by the author of this vignette to be more accurate than -those obtained using a re-estimation of the Hessian matrix after -backtransformation, as implemented in the FME package.</p> -</div> -<div class="section level3"> -<h3 id="parameter-t-test-based-on-untransformed-parameters">Parameter t-test based on untransformed parameters<a class="anchor" aria-label="anchor" href="#parameter-t-test-based-on-untransformed-parameters"></a> -</h3> -<p>The standard output of many nonlinear regression software packages -includes the results from a test for significant difference from zero -for all parameters. Such a test is also recommended to check the -validity of rate constants in the FOCUS guidance <span class="citation">(FOCUS Work Group on Degradation Kinetics 2014, -96ff)</span>.</p> -<p>It has been argued that the precondition for this test, <em>i.e.</em> -normal distribution of the estimator for the parameters, is not -fulfilled in the case of nonlinear regression <span class="citation">(J. -Ranke and Lehmann 2015)</span>. However, this test is commonly used by -industry, consultants and national authorities in order to decide on the -reliability of parameter estimates, based on the FOCUS guidance -mentioned above. Therefore, the results of this one-sided t-test are -included in the summary output from <code>mkin</code>.</p> -<p>As it is not reasonable to test for significant difference of the -transformed parameters (<em>e.g.</em> <span class="math inline">\(log(k)\)</span>) from zero, the t-test is -calculated based on the model definition before parameter -transformation, <em>i.e.</em> in a similar way as in packages that do -not apply such an internal parameter transformation. A note is included -in the <code>mkin</code> output, pointing to the fact that the t-test is -based on the unjustified assumption of normal distribution of the -parameter estimators.</p> -</div> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<!-- vim: set foldmethod=syntax: --> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-bates1988" class="csl-entry"> -Bates, D., and D. Watts. 1988. <em>Nonlinear Regression and Its -Applications</em>. Wiley-Interscience. -</div> -<div id="ref-FOCUS2006" class="csl-entry"> -FOCUS Work Group on Degradation Kinetics. 2006. <em>Guidance Document on -Estimating Persistence and Degradation Kinetics from Environmental Fate -Studies on Pesticides in EU Registration. Report of the FOCUS Work Group -on Degradation Kinetics</em>. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>. -</div> -<div id="ref-FOCUSkinetics2014" class="csl-entry"> -———. 2014. <em>Generic Guidance for Estimating Persistence and -Degradation Kinetics from Environmental Fate Studies on Pesticides in EU -Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>. -</div> -<div id="ref-gao11" class="csl-entry"> -Gao, Z., J. W. Green, J. Vanderborght, and W. Schmitt. 2011. -<span>“Improving Uncertainty Analysis in Kinetic Evaluations Using -Iteratively Reweighted Least Squares.”</span> Journal. <em>Environmental -Science and Technology</em> 45: 4429–37. -</div> -<div id="ref-pkg:mkin" class="csl-entry"> -Ranke, J. 2021. <em>‘<span class="nocase">mkin</span>‘: -<span>K</span>inetic Evaluation of Chemical Degradation Data</em>. <a href="https://CRAN.R-project.org/package=mkin" class="external-link">https://CRAN.R-project.org/package=mkin</a>. -</div> -<div id="ref-ranke2012" class="csl-entry"> -Ranke, J., and R. Lehmann. 2012. <span>“Parameter Reliability in Kinetic -Evaluation of Environmental Metabolism Data - Assessment and the -Influence of Model Specification.”</span> In <em>SETAC World 20-24 -May</em>. Berlin. <a href="https://jrwb.de/posters/Poster_SETAC_2012_Kinetic_parameter_uncertainty_model_parameterization_Lehmann_Ranke.pdf" class="external-link">https://jrwb.de/posters/Poster_SETAC_2012_Kinetic_parameter_uncertainty_model_parameterization_Lehmann_Ranke.pdf</a>. -</div> -<div id="ref-ranke2015" class="csl-entry"> -———. 2015. <span>“To t-Test or Not to t-Test, That Is the -Question.”</span> In <em>XV Symposium on Pesticide Chemistry 2-4 -September 2015</em>. Piacenza. <a href="https://jrwb.de/posters/piacenza_2015.pdf" class="external-link">https://jrwb.de/posters/piacenza_2015.pdf</a>. -</div> -<div id="ref-ranke2019" class="csl-entry"> -Ranke, Johannes, and Stefan Meinecke. 2019. <span>“Error Models for the -Kinetic Evaluation of Chemical Degradation Data.”</span> -<em>Environments</em> 6 (12). <a href="https://doi.org/10.3390/environments6120124" class="external-link">https://doi.org/10.3390/environments6120124</a>. -</div> -<div id="ref-ranke2018" class="csl-entry"> -Ranke, Johannes, Janina Wöltjen, and Stefan Meinecke. 2018. -<span>“Comparison of Software Tools for Kinetic Evaluation of Chemical -Degradation Data.”</span> <em>Environmental Sciences Europe</em> 30 (1): -17. <a href="https://doi.org/10.1186/s12302-018-0145-1" class="external-link">https://doi.org/10.1186/s12302-018-0145-1</a>. -</div> -<div id="ref-schaefer2007" class="csl-entry"> -Schäfer, D., B. Mikolasch, P. Rainbird, and B. Harvey. 2007. -<span>“<span>KinGUI</span>: A New Kinetic Software Tool for Evaluations -According to <span>FOCUS</span> Degradation Kinetics.”</span> In -<em>Proceedings of the XIII Symposium Pesticide Chemistry</em>, edited -by Del Re A. A. M., Capri E., Fragoulis G., and Trevisan M., 916–23. -Piacenza. -</div> -<div id="ref-soetaert2010" class="csl-entry"> -Soetaert, Karline, and Thomas Petzoldt. 2010. <span>“Inverse Modelling, -Sensitivity and Monte Carlo Analysis in <span>R</span> Using Package -<span>FME</span>.”</span> <em>Journal of Statistical Software</em> 33 -(3): 1–28. <a href="https://doi.org/10.18637/jss.v033.i03" class="external-link">https://doi.org/10.18637/jss.v033.i03</a>. -</div> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/mkin_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/mkin_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/mkin_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) --> -// v0.0.1 -// Written by JooYoung Seo (jooyoung@psu.edu) and Atsushi Yasumoto on June 1st, 2020. - -document.addEventListener('DOMContentLoaded', function() { - const codeList = document.getElementsByClassName("sourceCode"); - for (var i = 0; i < codeList.length; i++) { - var linkList = codeList[i].getElementsByTagName('a'); - for (var j = 0; j < linkList.length; j++) { - if (linkList[j].innerHTML === "") { - linkList[j].setAttribute('aria-hidden', 'true'); - } - } - } -}); diff --git a/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.css b/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.css deleted file mode 100644 index 07aee5fc..00000000 --- a/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.css +++ /dev/null @@ -1,4 +0,0 @@ -/* Styles for section anchors */ -a.anchor-section {margin-left: 10px; visibility: hidden; color: inherit;} -a.anchor-section::before {content: '#';} -.hasAnchor:hover a.anchor-section {visibility: visible;} diff --git a/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.js b/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.js deleted file mode 100644 index 570f99a0..00000000 --- a/docs/dev/articles/mkin_files/anchor-sections-1.0/anchor-sections.js +++ /dev/null @@ -1,33 +0,0 @@ -// Anchor sections v1.0 written by Atsushi Yasumoto on Oct 3rd, 2020. -document.addEventListener('DOMContentLoaded', function() { - // Do nothing if AnchorJS is used - if (typeof window.anchors === 'object' && anchors.hasOwnProperty('hasAnchorJSLink')) { - return; - } - - const h = document.querySelectorAll('h1, h2, h3, h4, h5, h6'); - - // Do nothing if sections are already anchored - if (Array.from(h).some(x => x.classList.contains('hasAnchor'))) { - return null; - } - - // Use section id when pandoc runs with --section-divs - const section_id = function(x) { - return ((x.classList.contains('section') || (x.tagName === 'SECTION')) - ? x.id : ''); - }; - - // Add anchors - h.forEach(function(x) { - const id = x.id || section_id(x.parentElement); - if (id === '') { - return null; - } - let anchor = document.createElement('a'); - anchor.href = '#' + id; - anchor.classList = ['anchor-section']; - x.classList.add('hasAnchor'); - x.appendChild(anchor); - }); -}); diff --git a/docs/dev/articles/mkin_files/figure-html/unnamed-chunk-2-1.png b/docs/dev/articles/mkin_files/figure-html/unnamed-chunk-2-1.png Binary files differdeleted file mode 100644 index 7ba861ea..00000000 --- a/docs/dev/articles/mkin_files/figure-html/unnamed-chunk-2-1.png +++ /dev/null diff --git a/docs/dev/articles/mkin_files/header-attrs-2.6/header-attrs.js b/docs/dev/articles/mkin_files/header-attrs-2.6/header-attrs.js deleted file mode 100644 index dd57d92e..00000000 --- a/docs/dev/articles/mkin_files/header-attrs-2.6/header-attrs.js +++ /dev/null @@ -1,12 +0,0 @@ -// Pandoc 2.9 adds attributes on both header and div. 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<div class="hidden name"><code>2022_cyan_pathway.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>The purpose of this document is to test demonstrate how nonlinear -hierarchical models (NLHM) based on the parent degradation models SFO, -FOMC, DFOP and HS, with serial formation of two or more metabolites can -be fitted with the mkin package.</p> -<p>It was assembled in the course of work package 1.2 of Project Number -173340 (Application of nonlinear hierarchical models to the kinetic -evaluation of chemical degradation data) of the German Environment -Agency carried out in 2022 and 2023.</p> -<p>The mkin package is used in version 1.2.4 which is currently under -development. The newly introduced functionality that is used here is a -simplification of excluding random effects for a set of fits based on a -related set of fits with a reduced model, and the documentation of the -starting parameters of the fit, so that all starting parameters of -<code>saem</code> fits are now listed in the summary. The -<code>saemix</code> package is used as a backend for fitting the NLHM, -but is also loaded to make the convergence plot function available.</p> -<p>This document is processed with the <code>knitr</code> package, which -also provides the <code>kable</code> function that is used to improve -the display of tabular data in R markdown documents. For parallel -processing, the <code>parallel</code> package is used.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://yihui.org/knitr/" class="external-link">knitr</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">parallel</span><span class="op">)</span></span> -<span><span class="va">n_cores</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># We need to start a new cluster after defining a compiled model that is</span></span> -<span><span class="co"># saved as a DLL to the user directory, therefore we define a function</span></span> -<span><span class="co"># This is used again after defining the pathway model</span></span> -<span><span class="va">start_cluster</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ret</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span> <span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">ret</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makeForkCluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span> <span class="op">}</span></span> -<span> <span class="kw"><a href="https://rdrr.io/r/base/function.html" class="external-link">return</a></span><span class="op">(</span><span class="va">ret</span><span class="op">)</span></span> -<span><span class="op">}</span></span> -<span><span class="va">cl</span> <span class="op"><-</span> <span class="fu">start_cluster</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span></code></pre></div> -<div class="section level3"> -<h3 id="test-data">Test data<a class="anchor" aria-label="anchor" href="#test-data"></a> -</h3> -<p>The example data are taken from the final addendum to the DAR from -2014 and are distributed with the mkin package. Residue data and time -step normalisation factors are read in using the function -<code>read_spreadsheet</code> from the mkin package. This function also -performs the time step normalisation.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">data_file</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.file.html" class="external-link">system.file</a></span><span class="op">(</span></span> -<span> <span class="st">"testdata"</span>, <span class="st">"cyantraniliprole_soil_efsa_2014.xlsx"</span>,</span> -<span> package <span class="op">=</span> <span class="st">"mkin"</span><span class="op">)</span></span> -<span><span class="va">cyan_ds</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/read_spreadsheet.html">read_spreadsheet</a></span><span class="op">(</span><span class="va">data_file</span>, parent_only <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<p>The following tables show the covariate data and the 5 datasets that -were read in from the spreadsheet file.</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">pH</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/attr.html" class="external-link">attr</a></span><span class="op">(</span><span class="va">cyan_ds</span>, <span class="st">"covariates"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="va">pH</span>, caption <span class="op">=</span> <span class="st">"Covariate data"</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<caption>Covariate data</caption> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">pH</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Nambsheim</td> -<td align="right">7.90</td> -</tr> -<tr class="even"> -<td align="left">Tama</td> -<td align="right">6.20</td> -</tr> -<tr class="odd"> -<td align="left">Gross-Umstadt</td> -<td align="right">7.04</td> -</tr> -<tr class="even"> -<td align="left">Sassafras</td> -<td align="right">4.62</td> -</tr> -<tr class="odd"> -<td align="left">Lleida</td> -<td align="right">8.05</td> -</tr> -</tbody> -</table> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">for</span> <span class="op">(</span><span class="va">ds_name</span> <span class="kw">in</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">cyan_ds</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span></span> -<span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mkin_long_to_wide.html">mkin_long_to_wide</a></span><span class="op">(</span><span class="va">cyan_ds</span><span class="op">[[</span><span class="va">ds_name</span><span class="op">]</span><span class="op">]</span><span class="op">)</span>,</span> -<span> caption <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="va">ds_name</span><span class="op">)</span>,</span> -<span> booktabs <span class="op">=</span> <span class="cn">TRUE</span>, row.names <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span><span class="st">"\n\\clearpage\n"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<table class="table"> -<caption>Dataset Nambsheim</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">cyan</th> -<th align="right">JCZ38</th> -<th align="right">J9C38</th> -<th align="right">JSE76</th> -<th align="right">J9Z38</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">105.79</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">3.210424</td> -<td align="right">77.26</td> -<td align="right">7.92</td> -<td align="right">11.94</td> -<td align="right">5.58</td> -<td align="right">9.12</td> -</tr> -<tr class="odd"> -<td align="right">7.490988</td> -<td align="right">57.13</td> -<td align="right">15.46</td> -<td align="right">16.58</td> -<td align="right">12.59</td> -<td align="right">11.74</td> -</tr> -<tr class="even"> -<td align="right">17.122259</td> -<td align="right">37.74</td> -<td align="right">15.98</td> -<td align="right">13.36</td> -<td align="right">26.05</td> -<td align="right">10.77</td> -</tr> -<tr class="odd"> -<td align="right">23.543105</td> -<td align="right">31.47</td> -<td align="right">6.05</td> -<td align="right">14.49</td> -<td align="right">34.71</td> -<td align="right">4.96</td> -</tr> -<tr class="even"> -<td align="right">43.875788</td> -<td align="right">16.74</td> -<td align="right">6.07</td> -<td align="right">7.57</td> -<td align="right">40.38</td> -<td align="right">6.52</td> -</tr> -<tr class="odd"> -<td align="right">67.418893</td> -<td align="right">8.85</td> -<td align="right">10.34</td> -<td align="right">6.39</td> -<td align="right">30.71</td> -<td align="right">8.90</td> -</tr> -<tr class="even"> -<td align="right">107.014116</td> -<td align="right">5.19</td> -<td align="right">9.61</td> -<td align="right">1.95</td> -<td align="right">20.41</td> -<td align="right">12.93</td> -</tr> -<tr class="odd"> -<td align="right">129.487080</td> -<td align="right">3.45</td> -<td align="right">6.18</td> -<td align="right">1.36</td> -<td align="right">21.78</td> -<td align="right">6.99</td> -</tr> -<tr class="even"> -<td align="right">195.835832</td> -<td align="right">2.15</td> -<td align="right">9.13</td> -<td align="right">0.95</td> -<td align="right">16.29</td> -<td align="right">7.69</td> -</tr> -<tr class="odd"> -<td align="right">254.693596</td> -<td align="right">1.92</td> -<td align="right">6.92</td> -<td align="right">0.20</td> -<td align="right">13.57</td> -<td align="right">7.16</td> -</tr> -<tr class="even"> -<td align="right">321.042348</td> -<td align="right">2.26</td> -<td align="right">7.02</td> -<td align="right">NA</td> -<td align="right">11.12</td> -<td align="right">8.66</td> -</tr> -<tr class="odd"> -<td align="right">383.110535</td> -<td align="right">NA</td> -<td align="right">5.05</td> -<td align="right">NA</td> -<td align="right">10.64</td> -<td align="right">5.56</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">105.57</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">3.210424</td> -<td align="right">78.88</td> -<td align="right">12.77</td> -<td align="right">11.94</td> -<td align="right">5.47</td> -<td align="right">9.12</td> -</tr> -<tr class="even"> -<td align="right">7.490988</td> -<td align="right">59.94</td> -<td align="right">15.27</td> -<td align="right">16.58</td> -<td align="right">13.60</td> -<td align="right">11.74</td> -</tr> -<tr class="odd"> -<td align="right">17.122259</td> -<td align="right">39.67</td> -<td align="right">14.26</td> -<td align="right">13.36</td> -<td align="right">29.44</td> -<td align="right">10.77</td> -</tr> -<tr class="even"> -<td align="right">23.543105</td> -<td align="right">30.21</td> -<td align="right">16.07</td> -<td align="right">14.49</td> -<td align="right">35.90</td> -<td align="right">4.96</td> -</tr> -<tr class="odd"> -<td align="right">43.875788</td> -<td align="right">18.06</td> -<td align="right">9.44</td> -<td align="right">7.57</td> -<td align="right">42.30</td> -<td align="right">6.52</td> -</tr> -<tr class="even"> -<td align="right">67.418893</td> -<td align="right">8.54</td> -<td align="right">5.78</td> -<td align="right">6.39</td> -<td align="right">34.70</td> -<td align="right">8.90</td> -</tr> -<tr class="odd"> -<td align="right">107.014116</td> -<td align="right">7.26</td> -<td align="right">4.54</td> -<td align="right">1.95</td> -<td align="right">23.33</td> -<td align="right">12.93</td> -</tr> -<tr class="even"> -<td align="right">129.487080</td> -<td align="right">3.60</td> -<td align="right">4.22</td> -<td align="right">1.36</td> -<td align="right">23.56</td> -<td align="right">6.99</td> -</tr> -<tr class="odd"> -<td align="right">195.835832</td> -<td align="right">2.84</td> -<td align="right">3.05</td> -<td align="right">0.95</td> -<td align="right">16.21</td> -<td align="right">7.69</td> -</tr> -<tr class="even"> -<td align="right">254.693596</td> -<td align="right">2.00</td> -<td align="right">2.90</td> -<td align="right">0.20</td> -<td align="right">15.53</td> -<td align="right">7.16</td> -</tr> -<tr class="odd"> -<td align="right">321.042348</td> -<td align="right">1.79</td> -<td align="right">0.94</td> -<td align="right">NA</td> -<td align="right">9.80</td> -<td align="right">8.66</td> -</tr> -<tr class="even"> -<td align="right">383.110535</td> -<td align="right">NA</td> -<td align="right">1.82</td> -<td align="right">NA</td> -<td align="right">9.49</td> -<td align="right">5.56</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Tama</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">cyan</th> -<th align="right">JCZ38</th> -<th align="right">J9Z38</th> -<th align="right">JSE76</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">106.14</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">2.400833</td> -<td align="right">93.47</td> -<td align="right">6.46</td> -<td align="right">2.85</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">5.601943</td> -<td align="right">88.39</td> -<td align="right">10.86</td> -<td align="right">4.65</td> -<td align="right">3.85</td> -</tr> -<tr class="even"> -<td align="right">12.804442</td> -<td align="right">72.29</td> -<td align="right">11.97</td> -<td align="right">4.91</td> -<td align="right">11.24</td> -</tr> -<tr class="odd"> -<td align="right">17.606108</td> -<td align="right">65.79</td> -<td align="right">13.11</td> -<td align="right">6.63</td> -<td align="right">13.79</td> -</tr> -<tr class="even"> -<td align="right">32.811382</td> -<td align="right">53.16</td> -<td align="right">11.24</td> -<td align="right">8.90</td> -<td align="right">23.40</td> -</tr> -<tr class="odd"> -<td align="right">50.417490</td> -<td align="right">44.01</td> -<td align="right">11.34</td> -<td align="right">9.98</td> -<td align="right">29.56</td> -</tr> -<tr class="even"> -<td align="right">80.027761</td> -<td align="right">33.23</td> -<td align="right">8.82</td> -<td align="right">11.31</td> -<td align="right">35.63</td> -</tr> -<tr class="odd"> -<td align="right">96.833591</td> -<td align="right">40.68</td> -<td align="right">5.94</td> -<td align="right">8.32</td> -<td align="right">29.09</td> -</tr> -<tr class="even"> -<td align="right">146.450803</td> -<td align="right">20.65</td> -<td align="right">4.49</td> -<td align="right">8.72</td> -<td align="right">36.88</td> -</tr> -<tr class="odd"> -<td align="right">190.466072</td> -<td align="right">17.71</td> -<td align="right">4.66</td> -<td align="right">11.10</td> -<td align="right">40.97</td> -</tr> -<tr class="even"> -<td align="right">240.083284</td> -<td align="right">14.86</td> -<td align="right">2.27</td> -<td align="right">11.62</td> -<td align="right">40.11</td> -</tr> -<tr class="odd"> -<td align="right">286.499386</td> -<td align="right">12.02</td> -<td align="right">NA</td> -<td align="right">10.73</td> -<td align="right">42.58</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">109.11</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">2.400833</td> -<td align="right">96.84</td> -<td align="right">5.52</td> -<td align="right">2.04</td> -<td align="right">2.02</td> -</tr> -<tr class="even"> -<td align="right">5.601943</td> -<td align="right">85.29</td> -<td align="right">9.65</td> -<td align="right">2.99</td> -<td align="right">4.39</td> -</tr> -<tr class="odd"> -<td align="right">12.804442</td> -<td align="right">73.68</td> -<td align="right">12.48</td> -<td align="right">5.05</td> -<td align="right">11.47</td> -</tr> -<tr class="even"> -<td align="right">17.606108</td> -<td align="right">64.89</td> -<td align="right">12.44</td> -<td align="right">6.29</td> -<td align="right">15.00</td> -</tr> -<tr class="odd"> -<td align="right">32.811382</td> -<td align="right">52.27</td> -<td align="right">10.86</td> -<td align="right">7.65</td> -<td align="right">23.30</td> -</tr> -<tr class="even"> -<td align="right">50.417490</td> -<td align="right">42.61</td> -<td align="right">10.54</td> -<td align="right">9.37</td> -<td align="right">31.06</td> -</tr> -<tr class="odd"> -<td align="right">80.027761</td> -<td align="right">34.29</td> -<td align="right">10.02</td> -<td align="right">9.04</td> -<td align="right">37.87</td> -</tr> -<tr class="even"> -<td align="right">96.833591</td> -<td align="right">30.50</td> -<td align="right">6.34</td> -<td align="right">8.14</td> -<td align="right">33.97</td> -</tr> -<tr class="odd"> -<td align="right">146.450803</td> -<td align="right">19.21</td> -<td align="right">6.29</td> -<td align="right">8.52</td> -<td align="right">26.15</td> -</tr> -<tr class="even"> -<td align="right">190.466072</td> -<td align="right">17.55</td> -<td align="right">5.81</td> -<td align="right">9.89</td> -<td align="right">32.08</td> -</tr> -<tr class="odd"> -<td align="right">240.083284</td> -<td align="right">13.22</td> -<td align="right">5.99</td> -<td align="right">10.79</td> -<td align="right">40.66</td> -</tr> -<tr class="even"> -<td align="right">286.499386</td> -<td align="right">11.09</td> -<td align="right">6.05</td> -<td align="right">8.82</td> -<td align="right">42.90</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Gross-Umstadt</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">cyan</th> -<th align="right">JCZ38</th> -<th align="right">J9Z38</th> -<th align="right">JSE76</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">103.03</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">2.1014681</td> -<td align="right">87.85</td> -<td align="right">4.79</td> -<td align="right">3.26</td> -<td align="right">0.62</td> -</tr> -<tr class="odd"> -<td align="right">4.9034255</td> -<td align="right">77.35</td> -<td align="right">8.05</td> -<td align="right">9.89</td> -<td align="right">1.32</td> -</tr> -<tr class="even"> -<td align="right">10.5073404</td> -<td align="right">69.33</td> -<td align="right">9.74</td> -<td align="right">12.32</td> -<td align="right">4.74</td> -</tr> -<tr class="odd"> -<td align="right">21.0146807</td> -<td align="right">55.65</td> -<td align="right">14.57</td> -<td align="right">13.59</td> -<td align="right">9.84</td> -</tr> -<tr class="even"> -<td align="right">31.5220211</td> -<td align="right">49.03</td> -<td align="right">14.66</td> -<td align="right">16.71</td> -<td align="right">12.32</td> -</tr> -<tr class="odd"> -<td align="right">42.0293615</td> -<td align="right">41.86</td> -<td align="right">15.97</td> -<td align="right">13.64</td> -<td align="right">15.53</td> -</tr> -<tr class="even"> -<td align="right">63.0440422</td> -<td align="right">34.88</td> -<td align="right">18.20</td> -<td align="right">14.12</td> -<td align="right">22.02</td> -</tr> -<tr class="odd"> -<td align="right">84.0587230</td> -<td align="right">28.26</td> -<td align="right">15.64</td> -<td align="right">14.06</td> -<td align="right">25.60</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">104.05</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">2.1014681</td> -<td align="right">85.25</td> -<td align="right">2.68</td> -<td align="right">7.32</td> -<td align="right">0.69</td> -</tr> -<tr class="even"> -<td align="right">4.9034255</td> -<td align="right">77.22</td> -<td align="right">7.28</td> -<td align="right">8.37</td> -<td align="right">1.45</td> -</tr> -<tr class="odd"> -<td align="right">10.5073404</td> -<td align="right">65.23</td> -<td align="right">10.73</td> -<td align="right">10.93</td> -<td align="right">4.74</td> -</tr> -<tr class="even"> -<td align="right">21.0146807</td> -<td align="right">57.78</td> -<td align="right">12.29</td> -<td align="right">14.80</td> -<td align="right">9.05</td> -</tr> -<tr class="odd"> -<td align="right">31.5220211</td> -<td align="right">54.83</td> -<td align="right">14.05</td> -<td align="right">12.01</td> -<td align="right">11.05</td> -</tr> -<tr class="even"> -<td align="right">42.0293615</td> -<td align="right">45.17</td> -<td align="right">12.12</td> -<td align="right">17.89</td> -<td align="right">15.71</td> -</tr> -<tr class="odd"> -<td align="right">63.0440422</td> -<td align="right">34.83</td> -<td align="right">12.90</td> -<td align="right">15.86</td> -<td align="right">22.52</td> -</tr> -<tr class="even"> -<td align="right">84.0587230</td> -<td align="right">26.59</td> -<td align="right">14.28</td> -<td align="right">14.91</td> -<td align="right">28.48</td> -</tr> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">104.62</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.8145225</td> -<td align="right">97.21</td> -<td align="right">NA</td> -<td align="right">4.00</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">1.9005525</td> -<td align="right">89.64</td> -<td align="right">3.59</td> -<td align="right">5.24</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">4.0726125</td> -<td align="right">87.90</td> -<td align="right">4.10</td> -<td align="right">9.58</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">8.1452251</td> -<td align="right">86.90</td> -<td align="right">5.96</td> -<td align="right">9.45</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">12.2178376</td> -<td align="right">74.74</td> -<td align="right">7.83</td> -<td align="right">15.03</td> -<td align="right">5.33</td> -</tr> -<tr class="odd"> -<td align="right">16.2904502</td> -<td align="right">74.13</td> -<td align="right">8.84</td> -<td align="right">14.41</td> -<td align="right">5.10</td> -</tr> -<tr class="even"> -<td align="right">24.4356753</td> -<td align="right">65.26</td> -<td align="right">11.84</td> -<td align="right">18.33</td> -<td align="right">6.71</td> -</tr> -<tr class="odd"> -<td align="right">32.5809004</td> -<td align="right">57.70</td> -<td align="right">12.74</td> -<td align="right">19.93</td> -<td align="right">9.74</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">101.94</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">0.8145225</td> -<td align="right">99.94</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">1.9005525</td> -<td align="right">94.87</td> -<td align="right">NA</td> -<td align="right">4.56</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">4.0726125</td> -<td align="right">86.96</td> -<td align="right">6.75</td> -<td align="right">6.90</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">8.1452251</td> -<td align="right">80.51</td> -<td align="right">10.68</td> -<td align="right">7.43</td> -<td align="right">2.58</td> -</tr> -<tr class="odd"> -<td align="right">12.2178376</td> -<td align="right">78.38</td> -<td align="right">10.35</td> -<td align="right">9.46</td> -<td align="right">3.69</td> -</tr> -<tr class="even"> -<td align="right">16.2904502</td> -<td align="right">70.05</td> -<td align="right">13.73</td> -<td align="right">9.27</td> -<td align="right">7.18</td> -</tr> -<tr class="odd"> -<td align="right">24.4356753</td> -<td align="right">61.28</td> -<td align="right">12.57</td> -<td align="right">13.28</td> -<td align="right">13.19</td> -</tr> -<tr class="even"> -<td align="right">32.5809004</td> -<td align="right">52.85</td> -<td align="right">12.67</td> -<td align="right">12.95</td> -<td align="right">13.69</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Sassafras</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">cyan</th> -<th align="right">JCZ38</th> -<th align="right">J9Z38</th> -<th align="right">JSE76</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">102.17</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">2.216719</td> -<td align="right">95.49</td> -<td align="right">1.11</td> -<td align="right">0.10</td> -<td align="right">0.83</td> -</tr> -<tr class="odd"> -<td align="right">5.172343</td> -<td align="right">83.35</td> -<td align="right">6.43</td> -<td align="right">2.89</td> -<td align="right">3.30</td> -</tr> -<tr class="even"> -<td align="right">11.083593</td> -<td align="right">78.18</td> -<td align="right">10.00</td> -<td align="right">5.59</td> -<td align="right">0.81</td> -</tr> -<tr class="odd"> -<td align="right">22.167186</td> -<td align="right">70.44</td> -<td align="right">17.21</td> -<td align="right">4.23</td> -<td align="right">1.09</td> -</tr> -<tr class="even"> -<td align="right">33.250779</td> -<td align="right">68.00</td> -<td align="right">20.45</td> -<td align="right">5.86</td> -<td align="right">1.17</td> -</tr> -<tr class="odd"> -<td align="right">44.334371</td> -<td align="right">59.64</td> -<td align="right">24.64</td> -<td align="right">3.17</td> -<td align="right">2.72</td> -</tr> -<tr class="even"> -<td align="right">66.501557</td> -<td align="right">50.73</td> -<td align="right">27.50</td> -<td align="right">6.19</td> -<td align="right">1.27</td> -</tr> -<tr class="odd"> -<td align="right">88.668742</td> -<td align="right">45.65</td> -<td align="right">32.77</td> -<td align="right">5.69</td> -<td align="right">4.54</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">100.43</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">2.216719</td> -<td align="right">95.34</td> -<td align="right">3.21</td> -<td align="right">0.14</td> -<td align="right">0.46</td> -</tr> -<tr class="even"> -<td align="right">5.172343</td> -<td align="right">84.38</td> -<td align="right">5.73</td> -<td align="right">4.75</td> -<td align="right">0.62</td> -</tr> -<tr class="odd"> -<td align="right">11.083593</td> -<td align="right">78.50</td> -<td align="right">11.89</td> -<td align="right">3.99</td> -<td align="right">0.73</td> -</tr> -<tr class="even"> -<td align="right">22.167186</td> -<td align="right">71.17</td> -<td align="right">17.28</td> -<td align="right">4.39</td> -<td align="right">0.66</td> -</tr> -<tr class="odd"> -<td align="right">33.250779</td> -<td align="right">59.41</td> -<td align="right">18.73</td> -<td align="right">11.85</td> -<td align="right">2.65</td> -</tr> -<tr class="even"> -<td align="right">44.334371</td> -<td align="right">64.57</td> -<td align="right">22.93</td> -<td align="right">5.13</td> -<td align="right">2.01</td> -</tr> -<tr class="odd"> -<td align="right">66.501557</td> -<td align="right">49.08</td> -<td align="right">33.39</td> -<td align="right">5.67</td> -<td align="right">3.63</td> -</tr> -<tr class="even"> -<td align="right">88.668742</td> -<td align="right">40.41</td> -<td align="right">39.60</td> -<td align="right">5.93</td> -<td align="right">6.17</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Lleida</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">cyan</th> -<th align="right">JCZ38</th> -<th align="right">J9Z38</th> -<th align="right">JSE76</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">102.71</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">2.821051</td> -<td align="right">79.11</td> -<td align="right">5.70</td> -<td align="right">8.07</td> -<td align="right">0.97</td> -</tr> -<tr class="odd"> -<td align="right">6.582451</td> -<td align="right">70.03</td> -<td align="right">7.17</td> -<td align="right">11.31</td> -<td align="right">4.72</td> -</tr> -<tr class="even"> -<td align="right">14.105253</td> -<td align="right">50.93</td> -<td align="right">10.25</td> -<td align="right">14.84</td> -<td align="right">9.95</td> -</tr> -<tr class="odd"> -<td align="right">28.210505</td> -<td align="right">33.43</td> -<td align="right">10.40</td> -<td align="right">14.82</td> -<td align="right">24.06</td> -</tr> -<tr class="even"> -<td align="right">42.315758</td> -<td align="right">24.69</td> -<td align="right">9.75</td> -<td align="right">16.38</td> -<td align="right">29.38</td> -</tr> -<tr class="odd"> -<td align="right">56.421010</td> -<td align="right">22.99</td> -<td align="right">10.06</td> -<td align="right">15.51</td> -<td align="right">29.25</td> -</tr> -<tr class="even"> -<td align="right">84.631516</td> -<td align="right">14.63</td> -<td align="right">5.63</td> -<td align="right">14.74</td> -<td align="right">31.04</td> -</tr> -<tr class="odd"> -<td align="right">112.842021</td> -<td align="right">12.43</td> -<td align="right">4.17</td> -<td align="right">13.53</td> -<td align="right">33.28</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">99.31</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">2.821051</td> -<td align="right">82.07</td> -<td align="right">6.55</td> -<td align="right">5.60</td> -<td align="right">1.12</td> -</tr> -<tr class="even"> -<td align="right">6.582451</td> -<td align="right">70.65</td> -<td align="right">7.61</td> -<td align="right">8.01</td> -<td align="right">3.21</td> -</tr> -<tr class="odd"> -<td align="right">14.105253</td> -<td align="right">53.52</td> -<td align="right">11.48</td> -<td align="right">10.82</td> -<td align="right">12.24</td> -</tr> -<tr class="even"> -<td align="right">28.210505</td> -<td align="right">35.60</td> -<td align="right">11.19</td> -<td align="right">15.43</td> -<td align="right">23.53</td> -</tr> -<tr class="odd"> -<td align="right">42.315758</td> -<td align="right">34.26</td> -<td align="right">11.09</td> -<td align="right">13.26</td> -<td align="right">27.42</td> -</tr> -<tr class="even"> -<td align="right">56.421010</td> -<td align="right">21.79</td> -<td align="right">4.80</td> -<td align="right">18.30</td> -<td align="right">30.20</td> -</tr> -<tr class="odd"> -<td align="right">84.631516</td> -<td align="right">14.06</td> -<td align="right">6.30</td> -<td align="right">16.35</td> -<td align="right">32.32</td> -</tr> -<tr class="even"> -<td align="right">112.842021</td> -<td align="right">11.51</td> -<td align="right">5.57</td> -<td align="right">12.64</td> -<td align="right">32.51</td> -</tr> -</tbody> -</table> -</div> -</div> -<div class="section level2"> -<h2 id="parent-only-evaluations">Parent only evaluations<a class="anchor" aria-label="anchor" href="#parent-only-evaluations"></a> -</h2> -<p>As the pathway fits have very long run times, evaluations of the -parent data are performed first, in order to determine for each -hierarchical parent degradation model which random effects on the -degradation model parameters are ill-defined.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">cyan_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"SFORB"</span>, <span class="st">"HS"</span><span class="op">)</span>,</span> -<span> <span class="va">cyan_ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="va">cyan_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">cyan_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="va">cyan_saem_full</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">cyan_sep_const</span>, <span class="va">cyan_sep_tc</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">cyan_saem_full</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">SFORB</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>All fits converged successfully.</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">cyan_saem_full</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">sd(cyan_0)</td> -<td align="left">sd(cyan_0)</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">sd(log_beta)</td> -<td align="left">sd(cyan_0)</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">sd(cyan_0)</td> -<td align="left">sd(cyan_0), sd(log_k1)</td> -</tr> -<tr class="even"> -<td align="left">SFORB</td> -<td align="left">sd(cyan_free_0)</td> -<td align="left">sd(cyan_free_0), sd(log_k_cyan_free_bound)</td> -</tr> -<tr class="odd"> -<td align="left">HS</td> -<td align="left">sd(cyan_0)</td> -<td align="left">sd(cyan_0)</td> -</tr> -</tbody> -</table> -<p>In almost all models, the random effect for the initial concentration -of the parent compound is ill-defined. For the biexponential models DFOP -and SFORB, the random effect of one additional parameter is ill-defined -when the two-component error model is used.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">cyan_saem_full</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO const</td> -<td align="right">5</td> -<td align="right">833.9</td> -<td align="right">832.0</td> -<td align="right">-412.0</td> -</tr> -<tr class="even"> -<td align="left">SFO tc</td> -<td align="right">6</td> -<td align="right">831.6</td> -<td align="right">829.3</td> -<td align="right">-409.8</td> -</tr> -<tr class="odd"> -<td align="left">FOMC const</td> -<td align="right">7</td> -<td align="right">709.1</td> -<td align="right">706.4</td> -<td align="right">-347.6</td> -</tr> -<tr class="even"> -<td align="left">FOMC tc</td> -<td align="right">8</td> -<td align="right">689.2</td> -<td align="right">686.1</td> -<td align="right">-336.6</td> -</tr> -<tr class="odd"> -<td align="left">DFOP const</td> -<td align="right">9</td> -<td align="right">703.0</td> -<td align="right">699.5</td> -<td align="right">-342.5</td> -</tr> -<tr class="even"> -<td align="left">SFORB const</td> -<td align="right">9</td> -<td align="right">701.3</td> -<td align="right">697.8</td> -<td align="right">-341.7</td> -</tr> -<tr class="odd"> -<td align="left">HS const</td> -<td align="right">9</td> -<td align="right">718.6</td> -<td align="right">715.1</td> -<td align="right">-350.3</td> -</tr> -<tr class="even"> -<td align="left">DFOP tc</td> -<td align="right">10</td> -<td align="right">703.1</td> -<td align="right">699.2</td> -<td align="right">-341.6</td> -</tr> -<tr class="odd"> -<td align="left">SFORB tc</td> -<td align="right">10</td> -<td align="right">700.1</td> -<td align="right">696.2</td> -<td align="right">-340.1</td> -</tr> -<tr class="even"> -<td align="left">HS tc</td> -<td align="right">10</td> -<td align="right">716.7</td> -<td align="right">712.8</td> -<td align="right">-348.3</td> -</tr> -</tbody> -</table> -<p>Model comparison based on AIC and BIC indicates that the -two-component error model is preferable for all parent models with the -exception of DFOP. The lowest AIC and BIC values are are obtained with -the FOMC model, followed by SFORB and DFOP.</p> -<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="pathway-fits">Pathway fits<a class="anchor" aria-label="anchor" href="#pathway-fits"></a> -</h2> -<div class="section level3"> -<h3 id="evaluations-with-pathway-established-previously">Evaluations with pathway established previously<a class="anchor" aria-label="anchor" href="#evaluations-with-pathway-established-previously"></a> -</h3> -<p>To test the technical feasibility of coupling the relevant parent -degradation models with different transformation pathway models, a list -of <code>mkinmod</code> models is set up below. As in the EU evaluation, -parallel formation of metabolites JCZ38 and J9Z38 and secondary -formation of metabolite JSE76 from JCZ38 is used.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.exists</a></span><span class="op">(</span><span class="st">"cyan_dlls"</span><span class="op">)</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.create</a></span><span class="op">(</span><span class="st">"cyan_dlls"</span><span class="op">)</span></span> -<span><span class="va">cyan_path_1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span> sfo_path_1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> name <span class="op">=</span> <span class="st">"sfo_path_1"</span>, dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> fomc_path_1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> name <span class="op">=</span> <span class="st">"fomc_path_1"</span>, dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> dfop_path_1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> name <span class="op">=</span> <span class="st">"dfop_path_1"</span>, dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> sforb_path_1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> name <span class="op">=</span> <span class="st">"sforb_path_1"</span>, dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> hs_path_1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"HS"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> name <span class="op">=</span> <span class="st">"hs_path_1"</span>, dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="op">)</span></span> -<span><span class="va">cl_path_1</span> <span class="op"><-</span> <span class="fu">start_cluster</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span></code></pre></div> -<p>To obtain suitable starting values for the NLHM fits, separate -pathway fits are performed for all datasets.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_sep_1_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span></span> -<span> <span class="va">cyan_path_1</span>,</span> -<span> <span class="va">cyan_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> cluster <span class="op">=</span> <span class="va">cl_path_1</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_1_const</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Nambsheim</th> -<th align="left">Tama</th> -<th align="left">Gross-Umstadt</th> -<th align="left">Sassafras</th> -<th align="left">Lleida</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -</tr> -</tbody> -</table> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_sep_1_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_sep_1_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_1_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Nambsheim</th> -<th align="left">Tama</th> -<th align="left">Gross-Umstadt</th> -<th align="left">Sassafras</th> -<th align="left">Lleida</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>Most separate fits converged successfully. The biggest convergence -problems are seen when using the HS model with constant variance.</p> -<p>For the hierarchical pathway fits, those random effects that could -not be quantified in the corresponding parent data analyses are -excluded.</p> -<p>In the code below, the output of the <code>illparms</code> function -for the parent only fits is used as an argument -<code>no_random_effect</code> to the <code>mhmkin</code> function. The -possibility to do so was introduced in mkin version <code>1.2.2</code> -which is currently under development.</p> -<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_sep_1_const</span>, <span class="va">f_sep_1_tc</span><span class="op">)</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">cyan_saem_full</span><span class="op">)</span>,</span> -<span> cluster <span class="op">=</span> <span class="va">cl_path_1</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">Fth, FO</td> -<td align="left">Fth, FO</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">Fth, FO</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">Fth, FO</td> -<td align="left">Fth, FO</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">Fth, FO</td> -<td align="left">Fth, FO</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">Fth, FO</td> -<td align="left">Fth, FO</td> -</tr> -</tbody> -</table> -<p>The status information from the individual fits shows that all fits -completed successfully. The matrix entries Fth and FO indicate that the -Fisher Information Matrix could not be inverted for the fixed effects -(theta) and the random effects (Omega), respectively. For the affected -fits, ill-defined parameters cannot be determined using the -<code>illparms</code> function, because it relies on the Fisher -Information Matrix.</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<colgroup> -<col width="18%"> -<col width="77%"> -<col width="4%"> -</colgroup> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">NA</td> -<td align="left">NA</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">sd(log_k_J9Z38), sd(f_cyan_ilr_2), -sd(f_JCZ38_qlogis)</td> -<td align="left">NA</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">NA</td> -<td align="left">NA</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">NA</td> -<td align="left">NA</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">NA</td> -<td align="left">NA</td> -</tr> -</tbody> -</table> -<p>The model comparison below suggests that the pathway fits using DFOP -or SFORB for the parent compound provide the best fit.</p> -<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1 const</td> -<td align="right">16</td> -<td align="right">2692.8</td> -<td align="right">2686.6</td> -<td align="right">-1330.4</td> -</tr> -<tr class="even"> -<td align="left">sfo_path_1 tc</td> -<td align="right">17</td> -<td align="right">2657.7</td> -<td align="right">2651.1</td> -<td align="right">-1311.9</td> -</tr> -<tr class="odd"> -<td align="left">fomc_path_1 const</td> -<td align="right">18</td> -<td align="right">2427.8</td> -<td align="right">2420.8</td> -<td align="right">-1195.9</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1 tc</td> -<td align="right">19</td> -<td align="right">2423.4</td> -<td align="right">2416.0</td> -<td align="right">-1192.7</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1 const</td> -<td align="right">20</td> -<td align="right">2403.2</td> -<td align="right">2395.4</td> -<td align="right">-1181.6</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1 const</td> -<td align="right">20</td> -<td align="right">2401.4</td> -<td align="right">2393.6</td> -<td align="right">-1180.7</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1 const</td> -<td align="right">20</td> -<td align="right">2427.3</td> -<td align="right">2419.5</td> -<td align="right">-1193.7</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_1 tc</td> -<td align="right">20</td> -<td align="right">2398.0</td> -<td align="right">2390.2</td> -<td align="right">-1179.0</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_1 tc</td> -<td align="right">20</td> -<td align="right">2399.8</td> -<td align="right">2392.0</td> -<td align="right">-1179.9</td> -</tr> -<tr class="even"> -<td align="left">hs_path_1 tc</td> -<td align="right">21</td> -<td align="right">2422.3</td> -<td align="right">2414.1</td> -<td align="right">-1190.2</td> -</tr> -</tbody> -</table> -<p>For these two parent model, successful fits are shown below. Plots of -the fits with the other parent models are shown in the Appendix.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">[[</span><span class="st">"dfop_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-7-1.png" alt="DFOP pathway fit with two-component error" width="700"><p class="caption"> -DFOP pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-8-1.png" alt="SFORB pathway fit with two-component error" width="700"><p class="caption"> -SFORB pathway fit with two-component error -</p> -</div> -<p>A closer graphical analysis of these Figures shows that the residues -of transformation product JCZ38 in the soils Tama and Nambsheim observed -at later time points are strongly and systematically underestimated.</p> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl_path_1</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level3"> -<h3 id="alternative-pathway-fits">Alternative pathway fits<a class="anchor" aria-label="anchor" href="#alternative-pathway-fits"></a> -</h3> -<p>To improve the fit for JCZ38, a back-reaction from JSE76 to JCZ38 was -introduced in an alternative version of the transformation pathway, in -analogy to the back-reaction from K5A78 to K5A77. Both pairs of -transformation products are pairs of an organic acid with its -corresponding amide (Addendum 2014, p. 109). As FOMC provided the best -fit for the parent, and the biexponential models DFOP and SFORB provided -the best initial pathway fits, these three parent models are used in the -alternative pathway fits.</p> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">cyan_path_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span> fomc_path_2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JCZ38"</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"fomc_path_2"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>,</span> -<span> overwrite <span class="op">=</span> <span class="cn">TRUE</span></span> -<span> <span class="op">)</span>,</span> -<span> dfop_path_2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JCZ38"</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"dfop_path_2"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>,</span> -<span> overwrite <span class="op">=</span> <span class="cn">TRUE</span></span> -<span> <span class="op">)</span>,</span> -<span> sforb_path_2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> cyan <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"JCZ38"</span>, <span class="st">"J9Z38"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> JCZ38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JSE76"</span><span class="op">)</span>,</span> -<span> J9Z38 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> JSE76 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"JCZ38"</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"sforb_path_2"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> dll_dir <span class="op">=</span> <span class="st">"cyan_dlls"</span>,</span> -<span> overwrite <span class="op">=</span> <span class="cn">TRUE</span></span> -<span> <span class="op">)</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="va">cl_path_2</span> <span class="op"><-</span> <span class="fu">start_cluster</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="va">f_sep_2_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span></span> -<span> <span class="va">cyan_path_2</span>,</span> -<span> <span class="va">cyan_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> cluster <span class="op">=</span> <span class="va">cl_path_2</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_2_const</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Nambsheim</th> -<th align="left">Tama</th> -<th align="left">Gross-Umstadt</th> -<th align="left">Sassafras</th> -<th align="left">Lleida</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>Using constant variance, separate fits converge with the exception of -the fits to the Sassafras soil data.</p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_sep_2_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_sep_2_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_2_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Nambsheim</th> -<th align="left">Tama</th> -<th align="left">Gross-Umstadt</th> -<th align="left">Sassafras</th> -<th align="left">Lleida</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>Using the two-component error model, all separate fits converge with -the exception of the alternative pathway fit with DFOP used for the -parent and the Sassafras dataset.</p> -<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_2</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_sep_2_const</span>, <span class="va">f_sep_2_tc</span><span class="op">)</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">cyan_saem_full</span><span class="op">[</span><span class="fl">2</span><span class="op">:</span><span class="fl">4</span>, <span class="op">]</span><span class="op">)</span>,</span> -<span> cluster <span class="op">=</span> <span class="va">cl_path_2</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">OK</td> -<td align="left">FO</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>The hierarchical fits for the alternative pathway completed -successfully.</p> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<colgroup> -<col width="14%"> -<col width="42%"> -<col width="42%"> -</colgroup> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">sd(f_JCZ38_qlogis), sd(f_JSE76_qlogis)</td> -<td align="left">NA</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left">sd(f_JCZ38_qlogis), sd(f_JSE76_qlogis)</td> -<td align="left">sd(f_JCZ38_qlogis), sd(f_JSE76_qlogis)</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left">sd(f_JCZ38_qlogis), sd(f_JSE76_qlogis)</td> -<td align="left">sd(f_JCZ38_qlogis), sd(f_JSE76_qlogis)</td> -</tr> -</tbody> -</table> -<p>In both fits, the random effects for the formation fractions for the -pathways from JCZ38 to JSE76, and for the reverse pathway from JSE76 to -JCZ38 are ill-defined.</p> -<div class="sourceCode" id="cb24"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2 const</td> -<td align="right">20</td> -<td align="right">2308.3</td> -<td align="right">2300.5</td> -<td align="right">-1134.2</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_2 tc</td> -<td align="right">21</td> -<td align="right">2248.3</td> -<td align="right">2240.1</td> -<td align="right">-1103.2</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_2 const</td> -<td align="right">22</td> -<td align="right">2289.6</td> -<td align="right">2281.0</td> -<td align="right">-1122.8</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_2 const</td> -<td align="right">22</td> -<td align="right">2284.1</td> -<td align="right">2275.5</td> -<td align="right">-1120.0</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_2 tc</td> -<td align="right">22</td> -<td align="right">2234.4</td> -<td align="right">2225.8</td> -<td align="right">-1095.2</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_2 tc</td> -<td align="right">22</td> -<td align="right">2240.4</td> -<td align="right">2231.8</td> -<td align="right">-1098.2</td> -</tr> -</tbody> -</table> -<p>The variants using the biexponential models DFOP and SFORB for the -parent compound and the two-component error model give the lowest AIC -and BIC values and are plotted below. Compared with the original -pathway, the AIC and BIC values indicate a large improvement. This is -confirmed by the plots, which show that the metabolite JCZ38 is fitted -much better with this model.</p> -<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">[[</span><span class="st">"fomc_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-13-1.png" alt="FOMC pathway fit with two-component error, alternative pathway" width="700"><p class="caption"> -FOMC pathway fit with two-component error, alternative pathway -</p> -</div> -<div class="sourceCode" id="cb26"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">[[</span><span class="st">"dfop_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-14-1.png" alt="DFOP pathway fit with two-component error, alternative pathway" width="700"><p class="caption"> -DFOP pathway fit with two-component error, alternative pathway -</p> -</div> -<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">[[</span><span class="st">"sforb_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-15-1.png" alt="SFORB pathway fit with two-component error, alternative pathway" width="700"><p class="caption"> -SFORB pathway fit with two-component error, alternative pathway -</p> -</div> -</div> -<div class="section level3"> -<h3 id="refinement-of-alternative-pathway-fits">Refinement of alternative pathway fits<a class="anchor" aria-label="anchor" href="#refinement-of-alternative-pathway-fits"></a> -</h3> -<p>All ill-defined random effects that were identified in the parent -only fits and in the above pathway fits, are excluded for the final -evaluations below. For this purpose, a list of character vectors is -created below that can be indexed by row and column indices, and which -contains the degradation parameter names for which random effects should -be excluded for each of the hierarchical fits contained in -<code>f_saem_2</code>.</p> -<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">no_ranef</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">matrix</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="op">)</span>, nrow <span class="op">=</span> <span class="fl">3</span>, ncol <span class="op">=</span> <span class="fl">2</span>, dimnames <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/dimnames.html" class="external-link">dimnames</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"fomc_path_2"</span>, <span class="st">"const"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"log_beta"</span>, <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"fomc_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"cyan_0"</span>, <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"dfop_path_2"</span>, <span class="st">"const"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"cyan_0"</span>, <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"dfop_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"cyan_0"</span>, <span class="st">"log_k1"</span>, <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"sforb_path_2"</span>, <span class="st">"const"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"cyan_free_0"</span>,</span> -<span> <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="va">no_ranef</span><span class="op">[[</span><span class="st">"sforb_path_2"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"cyan_free_0"</span>, <span class="st">"log_k_cyan_free_bound"</span>,</span> -<span> <span class="st">"f_JCZ38_qlogis"</span>, <span class="st">"f_JSE76_qlogis"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/parallel/clusterApply.html" class="external-link">clusterExport</a></span><span class="op">(</span><span class="va">cl_path_2</span>, <span class="st">"no_ranef"</span><span class="op">)</span></span> -<span></span> -<span><span class="va">f_saem_3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_2</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="va">no_ranef</span>,</span> -<span> cluster <span class="op">=</span> <span class="va">cl_path_2</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_saem_3</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">E</td> -<td align="left">Fth</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left">Fth</td> -<td align="left">Fth</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left">Fth</td> -<td align="left">Fth</td> -</tr> -</tbody> -</table> -<p>With the exception of the FOMC pathway fit with constant variance, -all updated fits completed successfully. However, the Fisher Information -Matrix for the fixed effects (Fth) could not be inverted, so no -confidence intervals for the optimised parameters are available.</p> -<div class="sourceCode" id="cb30"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_3</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2</td> -<td align="left">E</td> -<td align="left"></td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2</td> -<td align="left"></td> -<td align="left"></td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2</td> -<td align="left"></td> -<td align="left"></td> -</tr> -</tbody> -</table> -<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_3</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">fomc_path_2 tc</td> -<td align="right">19</td> -<td align="right">2250.9</td> -<td align="right">2243.5</td> -<td align="right">-1106.5</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2 const</td> -<td align="right">20</td> -<td align="right">2281.7</td> -<td align="right">2273.9</td> -<td align="right">-1120.8</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2 const</td> -<td align="right">20</td> -<td align="right">2279.5</td> -<td align="right">2271.7</td> -<td align="right">-1119.7</td> -</tr> -<tr class="even"> -<td align="left">dfop_path_2 tc</td> -<td align="right">20</td> -<td align="right">2231.5</td> -<td align="right">2223.7</td> -<td align="right">-1095.8</td> -</tr> -<tr class="odd"> -<td align="left">sforb_path_2 tc</td> -<td align="right">20</td> -<td align="right">2235.7</td> -<td align="right">2227.9</td> -<td align="right">-1097.9</td> -</tr> -</tbody> -</table> -<p>While the AIC and BIC values of the best fit (DFOP pathway fit with -two-component error) are lower than in the previous fits with the -alternative pathway, the practical value of these refined evaluations is -limited as no confidence intervals are obtained.</p> -<div class="sourceCode" id="cb32"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl_path_2</span><span class="op">)</span></span></code></pre></div> -</div> -</div> -<div class="section level2"> -<h2 id="conclusion">Conclusion<a class="anchor" aria-label="anchor" href="#conclusion"></a> -</h2> -<p>It was demonstrated that a relatively complex transformation pathway -with parallel formation of two primary metabolites and one secondary -metabolite can be fitted even if the data in the individual datasets are -quite different and partly only cover the formation phase.</p> -<p>The run times of the pathway fits were several hours, limiting the -practical feasibility of iterative refinements based on ill-defined -parameters and of alternative checks of parameter identifiability based -on multistart runs.</p> -</div> -<div class="section level2"> -<h2 id="acknowledgements">Acknowledgements<a class="anchor" aria-label="anchor" href="#acknowledgements"></a> -</h2> -<p>The helpful comments by Janina Wöltjen of the German Environment -Agency are gratefully acknowledged.</p> -</div> -<div class="section level2"> -<h2 id="appendix">Appendix<a class="anchor" aria-label="anchor" href="#appendix"></a> -</h2> -<div class="section level3"> -<h3 id="plots-of-fits-that-were-not-refined-further">Plots of fits that were not refined further<a class="anchor" aria-label="anchor" href="#plots-of-fits-that-were-not-refined-further"></a> -</h3> -<div class="sourceCode" id="cb33"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">[[</span><span class="st">"sfo_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-20-1.png" alt="SFO pathway fit with two-component error" width="700"><p class="caption"> -SFO pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">[[</span><span class="st">"fomc_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-21-1.png" alt="FOMC pathway fit with two-component error" width="700"><p class="caption"> -FOMC pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb35"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_cyan_pathway_files/figure-html/unnamed-chunk-22-1.png" alt="HS pathway fit with two-component error" width="700"><p class="caption"> -HS pathway fit with two-component error -</p> -</div> -</div> -<div class="section level3"> -<h3 id="hierarchical-fit-listings">Hierarchical fit listings<a class="anchor" aria-label="anchor" href="#hierarchical-fit-listings"></a> -</h3> -<div class="section level4"> -<h4 id="pathway-1">Pathway 1<a class="anchor" aria-label="anchor" href="#pathway-1"></a> -</h4> -<caption> -Hierarchical SFO path 1 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:33:05 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - k_cyan * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * k_cyan * cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * k_cyan * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 438.011 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_cyan log_k_JCZ38 log_k_J9Z38 log_k_JSE76 - 95.3304 -3.8459 -3.1305 -5.0678 -5.3196 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis - 0.8158 22.5404 10.4289 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_cyan log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_0 4.797 0.0000 0.000 0.000 0.0000 -log_k_cyan 0.000 0.9619 0.000 0.000 0.0000 -log_k_JCZ38 0.000 0.0000 2.139 0.000 0.0000 -log_k_J9Z38 0.000 0.0000 0.000 1.639 0.0000 -log_k_JSE76 0.000 0.0000 0.000 0.000 0.7894 -f_cyan_ilr_1 0.000 0.0000 0.000 0.000 0.0000 -f_cyan_ilr_2 0.000 0.0000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.000 0.0000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis -cyan_0 0.0000 0.000 0.00 -log_k_cyan 0.0000 0.000 0.00 -log_k_JCZ38 0.0000 0.000 0.00 -log_k_J9Z38 0.0000 0.000 0.00 -log_k_JSE76 0.0000 0.000 0.00 -f_cyan_ilr_1 0.7714 0.000 0.00 -f_cyan_ilr_2 0.0000 8.684 0.00 -f_JCZ38_qlogis 0.0000 0.000 13.48 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2693 2687 -1330 - -Optimised parameters: - est. lower upper -cyan_0 95.0946 NA NA -log_k_cyan -3.8544 NA NA -log_k_JCZ38 -3.0402 NA NA -log_k_J9Z38 -5.0109 NA NA -log_k_JSE76 -5.2857 NA NA -f_cyan_ilr_1 0.8069 NA NA -f_cyan_ilr_2 16.6623 NA NA -f_JCZ38_qlogis 1.3602 NA NA -a.1 4.8326 NA NA -SD.log_k_cyan 0.5842 NA NA -SD.log_k_JCZ38 1.2680 NA NA -SD.log_k_J9Z38 0.3626 NA NA -SD.log_k_JSE76 0.5244 NA NA -SD.f_cyan_ilr_1 0.2752 NA NA -SD.f_cyan_ilr_2 2.3556 NA NA -SD.f_JCZ38_qlogis 0.2400 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan 0.5842 NA NA -SD.log_k_JCZ38 1.2680 NA NA -SD.log_k_J9Z38 0.3626 NA NA -SD.log_k_JSE76 0.5244 NA NA -SD.f_cyan_ilr_1 0.2752 NA NA -SD.f_cyan_ilr_2 2.3556 NA NA -SD.f_JCZ38_qlogis 0.2400 NA NA - -Variance model: - est. lower upper -a.1 4.833 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 95.094581 NA NA -k_cyan 0.021186 NA NA -k_JCZ38 0.047825 NA NA -k_J9Z38 0.006665 NA NA -k_JSE76 0.005063 NA NA -f_cyan_to_JCZ38 0.757885 NA NA -f_cyan_to_J9Z38 0.242115 NA NA -f_JCZ38_to_JSE76 0.795792 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 7.579e-01 -cyan_J9Z38 2.421e-01 -cyan_sink 5.877e-10 -JCZ38_JSE76 7.958e-01 -JCZ38_sink 2.042e-01 - -Estimated disappearance times: - DT50 DT90 -cyan 32.72 108.68 -JCZ38 14.49 48.15 -J9Z38 103.99 345.46 -JSE76 136.90 454.76 - -</code></pre> -<p></p> -<caption> -Hierarchical SFO path 1 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:32:55 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - k_cyan * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * k_cyan * cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * k_cyan * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 427.249 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_cyan log_k_JCZ38 log_k_J9Z38 log_k_JSE76 - 96.0039 -3.8907 -3.1276 -5.0069 -4.9367 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis - 0.7937 20.0030 15.1336 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_cyan log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_0 4.859 0.000 0.00 0.00 0.0000 -log_k_cyan 0.000 0.962 0.00 0.00 0.0000 -log_k_JCZ38 0.000 0.000 2.04 0.00 0.0000 -log_k_J9Z38 0.000 0.000 0.00 1.72 0.0000 -log_k_JSE76 0.000 0.000 0.00 0.00 0.9076 -f_cyan_ilr_1 0.000 0.000 0.00 0.00 0.0000 -f_cyan_ilr_2 0.000 0.000 0.00 0.00 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.00 0.00 0.0000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis -cyan_0 0.0000 0.000 0.00 -log_k_cyan 0.0000 0.000 0.00 -log_k_JCZ38 0.0000 0.000 0.00 -log_k_J9Z38 0.0000 0.000 0.00 -log_k_JSE76 0.0000 0.000 0.00 -f_cyan_ilr_1 0.7598 0.000 0.00 -f_cyan_ilr_2 0.0000 7.334 0.00 -f_JCZ38_qlogis 0.0000 0.000 11.78 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2658 2651 -1312 - -Optimised parameters: - est. lower upper -cyan_0 94.72923 NA NA -log_k_cyan -3.91670 NA NA -log_k_JCZ38 -3.12917 NA NA -log_k_J9Z38 -5.06070 NA NA -log_k_JSE76 -5.09254 NA NA -f_cyan_ilr_1 0.81116 NA NA -f_cyan_ilr_2 39.97850 NA NA -f_JCZ38_qlogis 3.09728 NA NA -a.1 3.95044 NA NA -b.1 0.07998 NA NA -SD.log_k_cyan 0.58855 NA NA -SD.log_k_JCZ38 1.29753 NA NA -SD.log_k_J9Z38 0.62851 NA NA -SD.log_k_JSE76 0.37235 NA NA -SD.f_cyan_ilr_1 0.37346 NA NA -SD.f_cyan_ilr_2 1.41667 NA NA -SD.f_JCZ38_qlogis 1.81467 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan 0.5886 NA NA -SD.log_k_JCZ38 1.2975 NA NA -SD.log_k_J9Z38 0.6285 NA NA -SD.log_k_JSE76 0.3724 NA NA -SD.f_cyan_ilr_1 0.3735 NA NA -SD.f_cyan_ilr_2 1.4167 NA NA -SD.f_JCZ38_qlogis 1.8147 NA NA - -Variance model: - est. lower upper -a.1 3.95044 NA NA -b.1 0.07998 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 94.729229 NA NA -k_cyan 0.019907 NA NA -k_JCZ38 0.043754 NA NA -k_J9Z38 0.006341 NA NA -k_JSE76 0.006142 NA NA -f_cyan_to_JCZ38 0.758991 NA NA -f_cyan_to_J9Z38 0.241009 NA NA -f_JCZ38_to_JSE76 0.956781 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.75899 -cyan_J9Z38 0.24101 -cyan_sink 0.00000 -JCZ38_JSE76 0.95678 -JCZ38_sink 0.04322 - -Estimated disappearance times: - DT50 DT90 -cyan 34.82 115.67 -JCZ38 15.84 52.63 -J9Z38 109.31 363.12 -JSE76 112.85 374.87 - -</code></pre> -<p></p> -<caption> -Hierarchical FOMC path 1 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:33:49 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 481.497 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.2314 -3.3680 -5.1108 -5.9416 0.7144 - f_cyan_ilr_2 f_JCZ38_qlogis log_alpha log_beta - 7.3870 15.7604 -0.1791 2.9811 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.416 0.000 0.0 0.000 0.0000 -log_k_JCZ38 0.000 2.439 0.0 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.7 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.0 1.856 0.0000 -f_cyan_ilr_1 0.000 0.000 0.0 0.000 0.7164 -f_cyan_ilr_2 0.000 0.000 0.0 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.0 0.000 0.0000 -log_alpha 0.000 0.000 0.0 0.000 0.0000 -log_beta 0.000 0.000 0.0 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_alpha log_beta -cyan_0 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 12.33 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.00 20.42 0.0000 0.0000 -log_alpha 0.00 0.00 0.4144 0.0000 -log_beta 0.00 0.00 0.0000 0.5077 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2428 2421 -1196 - -Optimised parameters: - est. lower upper -cyan_0 101.0225 98.306270 103.7387 -log_k_JCZ38 -3.3786 -4.770657 -1.9866 -log_k_J9Z38 -5.2603 -5.902085 -4.6186 -log_k_JSE76 -6.1427 -7.318336 -4.9671 -f_cyan_ilr_1 0.7437 0.421215 1.0663 -f_cyan_ilr_2 0.9108 0.267977 1.5537 -f_JCZ38_qlogis 2.0487 0.524897 3.5724 -log_alpha -0.2268 -0.618049 0.1644 -log_beta 2.8986 2.700701 3.0964 -a.1 3.4058 3.169913 3.6416 -SD.cyan_0 2.5279 0.454190 4.6016 -SD.log_k_JCZ38 1.5636 0.572824 2.5543 -SD.log_k_J9Z38 0.5316 -0.004405 1.0677 -SD.log_k_JSE76 0.9903 0.106325 1.8742 -SD.f_cyan_ilr_1 0.3464 0.112066 0.5807 -SD.f_cyan_ilr_2 0.2804 -0.393900 0.9546 -SD.f_JCZ38_qlogis 0.9416 -0.152986 2.0362 -SD.log_alpha 0.4273 0.161044 0.6936 - -Correlation: - cyan_0 l__JCZ3 l__J9Z3 l__JSE7 f_cy__1 f_cy__2 f_JCZ38 log_lph -log_k_JCZ38 -0.0156 -log_k_J9Z38 -0.0493 0.0073 -log_k_JSE76 -0.0329 0.0018 0.0069 -f_cyan_ilr_1 -0.0086 0.0180 -0.1406 0.0012 -f_cyan_ilr_2 -0.2629 0.0779 0.2826 0.0274 0.0099 -f_JCZ38_qlogis 0.0713 -0.0747 -0.0505 0.1169 -0.1022 -0.4893 -log_alpha -0.0556 0.0120 0.0336 0.0193 0.0036 0.0840 -0.0489 -log_beta -0.2898 0.0460 0.1305 0.0768 0.0190 0.4071 -0.1981 0.2772 - -Random effects: - est. lower upper -SD.cyan_0 2.5279 0.454190 4.6016 -SD.log_k_JCZ38 1.5636 0.572824 2.5543 -SD.log_k_J9Z38 0.5316 -0.004405 1.0677 -SD.log_k_JSE76 0.9903 0.106325 1.8742 -SD.f_cyan_ilr_1 0.3464 0.112066 0.5807 -SD.f_cyan_ilr_2 0.2804 -0.393900 0.9546 -SD.f_JCZ38_qlogis 0.9416 -0.152986 2.0362 -SD.log_alpha 0.4273 0.161044 0.6936 - -Variance model: - est. lower upper -a.1 3.406 3.17 3.642 - -Backtransformed parameters: - est. lower upper -cyan_0 1.010e+02 9.831e+01 1.037e+02 -k_JCZ38 3.409e-02 8.475e-03 1.372e-01 -k_J9Z38 5.194e-03 2.734e-03 9.867e-03 -k_JSE76 2.149e-03 6.633e-04 6.963e-03 -f_cyan_to_JCZ38 6.481e-01 NA NA -f_cyan_to_J9Z38 2.264e-01 NA NA -f_JCZ38_to_JSE76 8.858e-01 6.283e-01 9.727e-01 -alpha 7.971e-01 5.390e-01 1.179e+00 -beta 1.815e+01 1.489e+01 2.212e+01 - -Resulting formation fractions: - ff -cyan_JCZ38 0.6481 -cyan_J9Z38 0.2264 -cyan_sink 0.1255 -JCZ38_JSE76 0.8858 -JCZ38_sink 0.1142 - -Estimated disappearance times: - DT50 DT90 DT50back -cyan 25.15 308.01 92.72 -JCZ38 20.33 67.54 NA -J9Z38 133.46 443.35 NA -JSE76 322.53 1071.42 NA - -</code></pre> -<p></p> -<caption> -Hierarchical FOMC path 1 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:33:59 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 491.071 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.13827 -3.32493 -5.08921 -5.93478 0.71330 - f_cyan_ilr_2 f_JCZ38_qlogis log_alpha log_beta - 10.05989 12.79248 -0.09621 3.10646 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.643 0.000 0.000 0.00 0.0000 -log_k_JCZ38 0.000 2.319 0.000 0.00 0.0000 -log_k_J9Z38 0.000 0.000 1.731 0.00 0.0000 -log_k_JSE76 0.000 0.000 0.000 1.86 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.00 0.7186 -f_cyan_ilr_2 0.000 0.000 0.000 0.00 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.00 0.0000 -log_alpha 0.000 0.000 0.000 0.00 0.0000 -log_beta 0.000 0.000 0.000 0.00 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_alpha log_beta -cyan_0 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 12.49 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.00 20.19 0.0000 0.0000 -log_alpha 0.00 0.00 0.3142 0.0000 -log_beta 0.00 0.00 0.0000 0.7331 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2423 2416 -1193 - -Optimised parameters: - est. lower upper -cyan_0 100.57649 NA NA -log_k_JCZ38 -3.46250 NA NA -log_k_J9Z38 -5.24442 NA NA -log_k_JSE76 -5.75229 NA NA -f_cyan_ilr_1 0.68480 NA NA -f_cyan_ilr_2 0.61670 NA NA -f_JCZ38_qlogis 87.97407 NA NA -log_alpha -0.15699 NA NA -log_beta 3.01540 NA NA -a.1 3.11518 NA NA -b.1 0.04445 NA NA -SD.log_k_JCZ38 1.40732 NA NA -SD.log_k_J9Z38 0.56510 NA NA -SD.log_k_JSE76 0.72067 NA NA -SD.f_cyan_ilr_1 0.31199 NA NA -SD.f_cyan_ilr_2 0.36894 NA NA -SD.f_JCZ38_qlogis 6.92892 NA NA -SD.log_alpha 0.25662 NA NA -SD.log_beta 0.35845 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.4073 NA NA -SD.log_k_J9Z38 0.5651 NA NA -SD.log_k_JSE76 0.7207 NA NA -SD.f_cyan_ilr_1 0.3120 NA NA -SD.f_cyan_ilr_2 0.3689 NA NA -SD.f_JCZ38_qlogis 6.9289 NA NA -SD.log_alpha 0.2566 NA NA -SD.log_beta 0.3585 NA NA - -Variance model: - est. lower upper -a.1 3.11518 NA NA -b.1 0.04445 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.006e+02 NA NA -k_JCZ38 3.135e-02 NA NA -k_J9Z38 5.277e-03 NA NA -k_JSE76 3.175e-03 NA NA -f_cyan_to_JCZ38 5.991e-01 NA NA -f_cyan_to_J9Z38 2.275e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -alpha 8.547e-01 NA NA -beta 2.040e+01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.5991 -cyan_J9Z38 0.2275 -cyan_sink 0.1734 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 - -Estimated disappearance times: - DT50 DT90 DT50back -cyan 25.50 281.29 84.68 -JCZ38 22.11 73.44 NA -J9Z38 131.36 436.35 NA -JSE76 218.28 725.11 NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 1 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:34:33 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 525.551 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 102.0644 -3.4008 -5.0024 -5.8613 0.6855 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 g_qlogis - 1.2365 13.7245 -1.8641 -4.5063 -0.6468 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 4.466 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 2.382 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.595 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 1.245 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6852 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_k1 0.000 0.000 0.000 0.000 0.0000 -log_k2 0.000 0.000 0.000 0.000 0.0000 -g_qlogis 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 g_qlogis -cyan_0 0.00 0.00 0.0000 0.0000 0.000 -log_k_JCZ38 0.00 0.00 0.0000 0.0000 0.000 -log_k_J9Z38 0.00 0.00 0.0000 0.0000 0.000 -log_k_JSE76 0.00 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_1 0.00 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_2 1.28 0.00 0.0000 0.0000 0.000 -f_JCZ38_qlogis 0.00 16.11 0.0000 0.0000 0.000 -log_k1 0.00 0.00 0.9866 0.0000 0.000 -log_k2 0.00 0.00 0.0000 0.5953 0.000 -g_qlogis 0.00 0.00 0.0000 0.0000 1.583 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2403 2395 -1182 - -Optimised parameters: - est. lower upper -cyan_0 102.6079 NA NA -log_k_JCZ38 -3.4855 NA NA -log_k_J9Z38 -5.1686 NA NA -log_k_JSE76 -5.6697 NA NA -f_cyan_ilr_1 0.6714 NA NA -f_cyan_ilr_2 0.4986 NA NA -f_JCZ38_qlogis 55.4760 NA NA -log_k1 -1.8409 NA NA -log_k2 -4.4915 NA NA -g_qlogis -0.6403 NA NA -a.1 3.2387 NA NA -SD.log_k_JCZ38 1.4524 NA NA -SD.log_k_J9Z38 0.5151 NA NA -SD.log_k_JSE76 0.6514 NA NA -SD.f_cyan_ilr_1 0.3023 NA NA -SD.f_cyan_ilr_2 0.2959 NA NA -SD.f_JCZ38_qlogis 1.9984 NA NA -SD.log_k1 0.5188 NA NA -SD.log_k2 0.3894 NA NA -SD.g_qlogis 0.8579 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.4524 NA NA -SD.log_k_J9Z38 0.5151 NA NA -SD.log_k_JSE76 0.6514 NA NA -SD.f_cyan_ilr_1 0.3023 NA NA -SD.f_cyan_ilr_2 0.2959 NA NA -SD.f_JCZ38_qlogis 1.9984 NA NA -SD.log_k1 0.5188 NA NA -SD.log_k2 0.3894 NA NA -SD.g_qlogis 0.8579 NA NA - -Variance model: - est. lower upper -a.1 3.239 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.026e+02 NA NA -k_JCZ38 3.064e-02 NA NA -k_J9Z38 5.692e-03 NA NA -k_JSE76 3.449e-03 NA NA -f_cyan_to_JCZ38 5.798e-01 NA NA -f_cyan_to_J9Z38 2.243e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -k1 1.587e-01 NA NA -k2 1.120e-02 NA NA -g 3.452e-01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.5798 -cyan_J9Z38 0.2243 -cyan_sink 0.1958 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 25.21 167.73 50.49 4.368 61.87 -JCZ38 22.62 75.15 NA NA NA -J9Z38 121.77 404.50 NA NA NA -JSE76 200.98 667.64 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 1 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:37:03 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 675.804 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.3964 -3.3626 -4.9792 -5.8727 0.6814 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 g_qlogis - 6.7799 13.7245 -1.9222 -4.5035 -0.7172 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.317 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 2.272 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.633 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 1.271 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6838 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_k1 0.000 0.000 0.000 0.000 0.0000 -log_k2 0.000 0.000 0.000 0.000 0.0000 -g_qlogis 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 g_qlogis -cyan_0 0.00 0.00 0.0000 0.0000 0.000 -log_k_JCZ38 0.00 0.00 0.0000 0.0000 0.000 -log_k_J9Z38 0.00 0.00 0.0000 0.0000 0.000 -log_k_JSE76 0.00 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_1 0.00 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_2 11.77 0.00 0.0000 0.0000 0.000 -f_JCZ38_qlogis 0.00 16.11 0.0000 0.0000 0.000 -log_k1 0.00 0.00 0.9496 0.0000 0.000 -log_k2 0.00 0.00 0.0000 0.5846 0.000 -g_qlogis 0.00 0.00 0.0000 0.0000 1.719 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2398 2390 -1179 - -Optimised parameters: - est. lower upper -cyan_0 100.8076 NA NA -log_k_JCZ38 -3.4684 NA NA -log_k_J9Z38 -5.0844 NA NA -log_k_JSE76 -5.5743 NA NA -f_cyan_ilr_1 0.6669 NA NA -f_cyan_ilr_2 0.7912 NA NA -f_JCZ38_qlogis 84.1825 NA NA -log_k1 -2.1671 NA NA -log_k2 -4.5447 NA NA -g_qlogis -0.5631 NA NA -a.1 2.9627 NA NA -b.1 0.0444 NA NA -SD.log_k_JCZ38 1.4044 NA NA -SD.log_k_J9Z38 0.6410 NA NA -SD.log_k_JSE76 0.5391 NA NA -SD.f_cyan_ilr_1 0.3203 NA NA -SD.f_cyan_ilr_2 0.5038 NA NA -SD.f_JCZ38_qlogis 3.5865 NA NA -SD.log_k2 0.3119 NA NA -SD.g_qlogis 0.8276 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.4044 NA NA -SD.log_k_J9Z38 0.6410 NA NA -SD.log_k_JSE76 0.5391 NA NA -SD.f_cyan_ilr_1 0.3203 NA NA -SD.f_cyan_ilr_2 0.5038 NA NA -SD.f_JCZ38_qlogis 3.5865 NA NA -SD.log_k2 0.3119 NA NA -SD.g_qlogis 0.8276 NA NA - -Variance model: - est. lower upper -a.1 2.9627 NA NA -b.1 0.0444 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.008e+02 NA NA -k_JCZ38 3.117e-02 NA NA -k_J9Z38 6.193e-03 NA NA -k_JSE76 3.794e-03 NA NA -f_cyan_to_JCZ38 6.149e-01 NA NA -f_cyan_to_J9Z38 2.395e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -k1 1.145e-01 NA NA -k2 1.062e-02 NA NA -g 3.628e-01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.6149 -cyan_J9Z38 0.2395 -cyan_sink 0.1456 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 26.26 174.32 52.47 6.053 65.25 -JCZ38 22.24 73.88 NA NA NA -J9Z38 111.93 371.82 NA NA NA -JSE76 182.69 606.88 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 1 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:34:43 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 535.818 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 102.0643 -2.8987 -2.7077 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.4717 -3.4008 -5.0024 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -5.8613 0.6855 1.2366 - f_JCZ38_qlogis - 13.7418 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 4.466 0.0000 0.000 -log_k_cyan_free 0.000 0.6158 0.000 -log_k_cyan_free_bound 0.000 0.0000 1.463 -log_k_cyan_bound_free 0.000 0.0000 0.000 -log_k_JCZ38 0.000 0.0000 0.000 -log_k_J9Z38 0.000 0.0000 0.000 -log_k_JSE76 0.000 0.0000 0.000 -f_cyan_ilr_1 0.000 0.0000 0.000 -f_cyan_ilr_2 0.000 0.0000 0.000 -f_JCZ38_qlogis 0.000 0.0000 0.000 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.000 0.000 0.000 -log_k_cyan_free 0.000 0.000 0.000 0.000 -log_k_cyan_free_bound 0.000 0.000 0.000 0.000 -log_k_cyan_bound_free 1.058 0.000 0.000 0.000 -log_k_JCZ38 0.000 2.382 0.000 0.000 -log_k_J9Z38 0.000 0.000 1.595 0.000 -log_k_JSE76 0.000 0.000 0.000 1.245 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis -cyan_free_0 0.0000 0.00 0.00 -log_k_cyan_free 0.0000 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.00 0.00 -log_k_JCZ38 0.0000 0.00 0.00 -log_k_J9Z38 0.0000 0.00 0.00 -log_k_JSE76 0.0000 0.00 0.00 -f_cyan_ilr_1 0.6852 0.00 0.00 -f_cyan_ilr_2 0.0000 1.28 0.00 -f_JCZ38_qlogis 0.0000 0.00 16.14 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2401 2394 -1181 - -Optimised parameters: - est. lower upper -cyan_free_0 102.7803 NA NA -log_k_cyan_free -2.8068 NA NA -log_k_cyan_free_bound -2.5714 NA NA -log_k_cyan_bound_free -3.4426 NA NA -log_k_JCZ38 -3.4994 NA NA -log_k_J9Z38 -5.1148 NA NA -log_k_JSE76 -5.6335 NA NA -f_cyan_ilr_1 0.6597 NA NA -f_cyan_ilr_2 0.5132 NA NA -f_JCZ38_qlogis 37.2090 NA NA -a.1 3.2367 NA NA -SD.log_k_cyan_free 0.3161 NA NA -SD.log_k_cyan_free_bound 0.8103 NA NA -SD.log_k_cyan_bound_free 0.5554 NA NA -SD.log_k_JCZ38 1.4858 NA NA -SD.log_k_J9Z38 0.5859 NA NA -SD.log_k_JSE76 0.6195 NA NA -SD.f_cyan_ilr_1 0.3118 NA NA -SD.f_cyan_ilr_2 0.3344 NA NA -SD.f_JCZ38_qlogis 0.5518 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.3161 NA NA -SD.log_k_cyan_free_bound 0.8103 NA NA -SD.log_k_cyan_bound_free 0.5554 NA NA -SD.log_k_JCZ38 1.4858 NA NA -SD.log_k_J9Z38 0.5859 NA NA -SD.log_k_JSE76 0.6195 NA NA -SD.f_cyan_ilr_1 0.3118 NA NA -SD.f_cyan_ilr_2 0.3344 NA NA -SD.f_JCZ38_qlogis 0.5518 NA NA - -Variance model: - est. lower upper -a.1 3.237 NA NA - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.028e+02 NA NA -k_cyan_free 6.040e-02 NA NA -k_cyan_free_bound 7.643e-02 NA NA -k_cyan_bound_free 3.198e-02 NA NA -k_JCZ38 3.022e-02 NA NA -k_J9Z38 6.007e-03 NA NA -k_JSE76 3.576e-03 NA NA -f_cyan_free_to_JCZ38 5.787e-01 NA NA -f_cyan_free_to_J9Z38 2.277e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g -0.15646 0.01235 0.33341 - -Resulting formation fractions: - ff -cyan_free_JCZ38 0.5787 -cyan_free_J9Z38 0.2277 -cyan_free_sink 0.1936 -cyan_free 1.0000 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 24.48 153.7 46.26 4.43 56.15 -JCZ38 22.94 76.2 NA NA NA -J9Z38 115.39 383.3 NA NA NA -JSE76 193.84 643.9 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 1 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:37:02 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 674.859 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 101.3964 -2.9881 -2.7949 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.4376 -3.3626 -4.9792 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -5.8727 0.6814 6.8139 - f_JCZ38_qlogis - 13.7419 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 5.317 0.0000 0.000 -log_k_cyan_free 0.000 0.7301 0.000 -log_k_cyan_free_bound 0.000 0.0000 1.384 -log_k_cyan_bound_free 0.000 0.0000 0.000 -log_k_JCZ38 0.000 0.0000 0.000 -log_k_J9Z38 0.000 0.0000 0.000 -log_k_JSE76 0.000 0.0000 0.000 -f_cyan_ilr_1 0.000 0.0000 0.000 -f_cyan_ilr_2 0.000 0.0000 0.000 -f_JCZ38_qlogis 0.000 0.0000 0.000 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.000 0.000 0.000 -log_k_cyan_free 0.000 0.000 0.000 0.000 -log_k_cyan_free_bound 0.000 0.000 0.000 0.000 -log_k_cyan_bound_free 1.109 0.000 0.000 0.000 -log_k_JCZ38 0.000 2.272 0.000 0.000 -log_k_J9Z38 0.000 0.000 1.633 0.000 -log_k_JSE76 0.000 0.000 0.000 1.271 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis -cyan_free_0 0.0000 0.00 0.00 -log_k_cyan_free 0.0000 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.00 0.00 -log_k_JCZ38 0.0000 0.00 0.00 -log_k_J9Z38 0.0000 0.00 0.00 -log_k_JSE76 0.0000 0.00 0.00 -f_cyan_ilr_1 0.6838 0.00 0.00 -f_cyan_ilr_2 0.0000 11.84 0.00 -f_JCZ38_qlogis 0.0000 0.00 16.14 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2400 2392 -1180 - -Optimised parameters: - est. lower upper -cyan_free_0 100.69983 NA NA -log_k_cyan_free -3.11584 NA NA -log_k_cyan_free_bound -3.15216 NA NA -log_k_cyan_bound_free -3.65986 NA NA -log_k_JCZ38 -3.47811 NA NA -log_k_J9Z38 -5.08835 NA NA -log_k_JSE76 -5.55514 NA NA -f_cyan_ilr_1 0.66764 NA NA -f_cyan_ilr_2 0.78329 NA NA -f_JCZ38_qlogis 25.35245 NA NA -a.1 2.99088 NA NA -b.1 0.04346 NA NA -SD.log_k_cyan_free 0.48797 NA NA -SD.log_k_cyan_bound_free 0.27243 NA NA -SD.log_k_JCZ38 1.42450 NA NA -SD.log_k_J9Z38 0.63496 NA NA -SD.log_k_JSE76 0.55951 NA NA -SD.f_cyan_ilr_1 0.32687 NA NA -SD.f_cyan_ilr_2 0.48056 NA NA -SD.f_JCZ38_qlogis 0.43818 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.4880 NA NA -SD.log_k_cyan_bound_free 0.2724 NA NA -SD.log_k_JCZ38 1.4245 NA NA -SD.log_k_J9Z38 0.6350 NA NA -SD.log_k_JSE76 0.5595 NA NA -SD.f_cyan_ilr_1 0.3269 NA NA -SD.f_cyan_ilr_2 0.4806 NA NA -SD.f_JCZ38_qlogis 0.4382 NA NA - -Variance model: - est. lower upper -a.1 2.99088 NA NA -b.1 0.04346 NA NA - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.007e+02 NA NA -k_cyan_free 4.434e-02 NA NA -k_cyan_free_bound 4.276e-02 NA NA -k_cyan_bound_free 2.574e-02 NA NA -k_JCZ38 3.087e-02 NA NA -k_J9Z38 6.168e-03 NA NA -k_JSE76 3.868e-03 NA NA -f_cyan_free_to_JCZ38 6.143e-01 NA NA -f_cyan_free_to_J9Z38 2.389e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g -0.10161 0.01123 0.36636 - -Resulting formation fractions: - ff -cyan_free_JCZ38 6.143e-01 -cyan_free_J9Z38 2.389e-01 -cyan_free_sink 1.468e-01 -cyan_free 1.000e+00 -JCZ38_JSE76 1.000e+00 -JCZ38_sink 9.763e-12 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 25.91 164.4 49.49 6.822 61.72 -JCZ38 22.46 74.6 NA NA NA -J9Z38 112.37 373.3 NA NA NA -JSE76 179.22 595.4 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical HS path 1 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:34:41 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ifelse(time <= tb, k1, k2) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ifelse(time <= tb, k1, k2) * cyan - - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ifelse(time <= tb, k1, k2) * cyan - - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 533.787 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 102.8738 -3.4490 -4.9348 -5.5989 0.6469 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb - 1.2854 9.7193 -2.9084 -4.1810 1.7813 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.409 0.00 0.00 0.000 0.0000 -log_k_JCZ38 0.000 2.33 0.00 0.000 0.0000 -log_k_J9Z38 0.000 0.00 1.59 0.000 0.0000 -log_k_JSE76 0.000 0.00 0.00 1.006 0.0000 -f_cyan_ilr_1 0.000 0.00 0.00 0.000 0.6371 -f_cyan_ilr_2 0.000 0.00 0.00 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.00 0.00 0.000 0.0000 -log_k1 0.000 0.00 0.00 0.000 0.0000 -log_k2 0.000 0.00 0.00 0.000 0.0000 -log_tb 0.000 0.00 0.00 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb -cyan_0 0.000 0.00 0.0000 0.0000 0.0000 -log_k_JCZ38 0.000 0.00 0.0000 0.0000 0.0000 -log_k_J9Z38 0.000 0.00 0.0000 0.0000 0.0000 -log_k_JSE76 0.000 0.00 0.0000 0.0000 0.0000 -f_cyan_ilr_1 0.000 0.00 0.0000 0.0000 0.0000 -f_cyan_ilr_2 2.167 0.00 0.0000 0.0000 0.0000 -f_JCZ38_qlogis 0.000 10.22 0.0000 0.0000 0.0000 -log_k1 0.000 0.00 0.7003 0.0000 0.0000 -log_k2 0.000 0.00 0.0000 0.8928 0.0000 -log_tb 0.000 0.00 0.0000 0.0000 0.6774 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2427 2420 -1194 - -Optimised parameters: - est. lower upper -cyan_0 101.84849 NA NA -log_k_JCZ38 -3.47365 NA NA -log_k_J9Z38 -5.10562 NA NA -log_k_JSE76 -5.60318 NA NA -f_cyan_ilr_1 0.66127 NA NA -f_cyan_ilr_2 0.60283 NA NA -f_JCZ38_qlogis 45.06408 NA NA -log_k1 -3.10124 NA NA -log_k2 -4.39028 NA NA -log_tb 2.32256 NA NA -a.1 3.32683 NA NA -SD.log_k_JCZ38 1.41427 NA NA -SD.log_k_J9Z38 0.54767 NA NA -SD.log_k_JSE76 0.62147 NA NA -SD.f_cyan_ilr_1 0.30189 NA NA -SD.f_cyan_ilr_2 0.34960 NA NA -SD.f_JCZ38_qlogis 0.04644 NA NA -SD.log_k1 0.39534 NA NA -SD.log_k2 0.43468 NA NA -SD.log_tb 0.60781 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.41427 NA NA -SD.log_k_J9Z38 0.54767 NA NA -SD.log_k_JSE76 0.62147 NA NA -SD.f_cyan_ilr_1 0.30189 NA NA -SD.f_cyan_ilr_2 0.34960 NA NA -SD.f_JCZ38_qlogis 0.04644 NA NA -SD.log_k1 0.39534 NA NA -SD.log_k2 0.43468 NA NA -SD.log_tb 0.60781 NA NA - -Variance model: - est. lower upper -a.1 3.327 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.018e+02 NA NA -k_JCZ38 3.100e-02 NA NA -k_J9Z38 6.063e-03 NA NA -k_JSE76 3.686e-03 NA NA -f_cyan_to_JCZ38 5.910e-01 NA NA -f_cyan_to_J9Z38 2.320e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -k1 4.499e-02 NA NA -k2 1.240e-02 NA NA -tb 1.020e+01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.591 -cyan_J9Z38 0.232 -cyan_sink 0.177 -JCZ38_JSE76 1.000 -JCZ38_sink 0.000 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 29.09 158.91 47.84 15.41 55.91 -JCZ38 22.36 74.27 NA NA NA -J9Z38 114.33 379.80 NA NA NA -JSE76 188.04 624.66 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical HS path 1 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:34:39 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ifelse(time <= tb, k1, k2) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ifelse(time <= tb, k1, k2) * cyan - - k_JCZ38 * JCZ38 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ifelse(time <= tb, k1, k2) * cyan - - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 531.084 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.168 -3.358 -4.941 -5.794 0.676 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb - 5.740 13.863 -3.147 -4.262 2.173 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.79 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.00 2.271 0.000 0.000 0.0000 -log_k_J9Z38 0.00 0.000 1.614 0.000 0.0000 -log_k_JSE76 0.00 0.000 0.000 1.264 0.0000 -f_cyan_ilr_1 0.00 0.000 0.000 0.000 0.6761 -f_cyan_ilr_2 0.00 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.00 0.000 0.000 0.000 0.0000 -log_k1 0.00 0.000 0.000 0.000 0.0000 -log_k2 0.00 0.000 0.000 0.000 0.0000 -log_tb 0.00 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis log_k1 log_k2 log_tb -cyan_0 0.000 0.00 0.0000 0.0000 0.000 -log_k_JCZ38 0.000 0.00 0.0000 0.0000 0.000 -log_k_J9Z38 0.000 0.00 0.0000 0.0000 0.000 -log_k_JSE76 0.000 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_1 0.000 0.00 0.0000 0.0000 0.000 -f_cyan_ilr_2 9.572 0.00 0.0000 0.0000 0.000 -f_JCZ38_qlogis 0.000 19.19 0.0000 0.0000 0.000 -log_k1 0.000 0.00 0.8705 0.0000 0.000 -log_k2 0.000 0.00 0.0000 0.9288 0.000 -log_tb 0.000 0.00 0.0000 0.0000 1.065 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2422 2414 -1190 - -Optimised parameters: - est. lower upper -cyan_0 100.9521 NA NA -log_k_JCZ38 -3.4629 NA NA -log_k_J9Z38 -5.0346 NA NA -log_k_JSE76 -5.5722 NA NA -f_cyan_ilr_1 0.6560 NA NA -f_cyan_ilr_2 0.7983 NA NA -f_JCZ38_qlogis 42.7949 NA NA -log_k1 -3.1721 NA NA -log_k2 -4.4039 NA NA -log_tb 2.3994 NA NA -a.1 3.0586 NA NA -b.1 0.0380 NA NA -SD.log_k_JCZ38 1.3754 NA NA -SD.log_k_J9Z38 0.6703 NA NA -SD.log_k_JSE76 0.5876 NA NA -SD.f_cyan_ilr_1 0.3272 NA NA -SD.f_cyan_ilr_2 0.5300 NA NA -SD.f_JCZ38_qlogis 6.4465 NA NA -SD.log_k1 0.4135 NA NA -SD.log_k2 0.4182 NA NA -SD.log_tb 0.6035 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.3754 NA NA -SD.log_k_J9Z38 0.6703 NA NA -SD.log_k_JSE76 0.5876 NA NA -SD.f_cyan_ilr_1 0.3272 NA NA -SD.f_cyan_ilr_2 0.5300 NA NA -SD.f_JCZ38_qlogis 6.4465 NA NA -SD.log_k1 0.4135 NA NA -SD.log_k2 0.4182 NA NA -SD.log_tb 0.6035 NA NA - -Variance model: - est. lower upper -a.1 3.059 NA NA -b.1 0.038 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.010e+02 NA NA -k_JCZ38 3.134e-02 NA NA -k_J9Z38 6.509e-03 NA NA -k_JSE76 3.802e-03 NA NA -f_cyan_to_JCZ38 6.127e-01 NA NA -f_cyan_to_J9Z38 2.423e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -k1 4.191e-02 NA NA -k2 1.223e-02 NA NA -tb 1.102e+01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.6127 -cyan_J9Z38 0.2423 -cyan_sink 0.1449 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 29.94 161.54 48.63 16.54 56.68 -JCZ38 22.12 73.47 NA NA NA -J9Z38 106.50 353.77 NA NA NA -JSE76 182.30 605.60 NA NA NA - -</code></pre> -<p></p> -</div> -<div class="section level4"> -<h4 id="pathway-2">Pathway 2<a class="anchor" aria-label="anchor" href="#pathway-2"></a> -</h4> -<caption> -Hierarchical FOMC path 2 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:45:51 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_JCZ38 * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 517.002 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.8173 -1.8998 -5.1449 -2.5415 0.6705 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta - 4.4669 16.1281 13.3327 -0.2314 2.8738 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.742 0.000 0.000 0.00 0.0000 -log_k_JCZ38 0.000 1.402 0.000 0.00 0.0000 -log_k_J9Z38 0.000 0.000 1.718 0.00 0.0000 -log_k_JSE76 0.000 0.000 0.000 3.57 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.00 0.5926 -f_cyan_ilr_2 0.000 0.000 0.000 0.00 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.00 0.0000 -f_JSE76_qlogis 0.000 0.000 0.000 0.00 0.0000 -log_alpha 0.000 0.000 0.000 0.00 0.0000 -log_beta 0.000 0.000 0.000 0.00 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta -cyan_0 0.00 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.00 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.00 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 10.56 0.00 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.00 12.04 0.00 0.0000 0.0000 -f_JSE76_qlogis 0.00 0.00 15.26 0.0000 0.0000 -log_alpha 0.00 0.00 0.00 0.4708 0.0000 -log_beta 0.00 0.00 0.00 0.0000 0.4432 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2308 2301 -1134 - -Optimised parameters: - est. lower upper -cyan_0 101.9586 99.22024 104.69700 -log_k_JCZ38 -2.4861 -3.17661 -1.79560 -log_k_J9Z38 -5.3926 -6.08842 -4.69684 -log_k_JSE76 -3.1193 -4.12904 -2.10962 -f_cyan_ilr_1 0.7368 0.42085 1.05276 -f_cyan_ilr_2 0.6196 0.06052 1.17861 -f_JCZ38_qlogis 4.8970 -4.68003 14.47398 -f_JSE76_qlogis 4.4066 -1.02087 9.83398 -log_alpha -0.3021 -0.68264 0.07838 -log_beta 2.7438 2.57970 2.90786 -a.1 2.9008 2.69920 3.10245 -SD.cyan_0 2.7081 0.64216 4.77401 -SD.log_k_JCZ38 0.7043 0.19951 1.20907 -SD.log_k_J9Z38 0.6248 0.05790 1.19180 -SD.log_k_JSE76 1.0750 0.33157 1.81839 -SD.f_cyan_ilr_1 0.3429 0.11688 0.56892 -SD.f_cyan_ilr_2 0.4774 0.09381 0.86097 -SD.f_JCZ38_qlogis 1.5565 -7.83970 10.95279 -SD.f_JSE76_qlogis 1.6871 -1.25577 4.63000 -SD.log_alpha 0.4216 0.15913 0.68405 - -Correlation: - cyan_0 l__JCZ3 l__J9Z3 l__JSE7 f_cy__1 f_cy__2 f_JCZ38 f_JSE76 -log_k_JCZ38 -0.0167 -log_k_J9Z38 -0.0307 0.0057 -log_k_JSE76 -0.0032 0.1358 0.0009 -f_cyan_ilr_1 -0.0087 0.0206 -0.1158 -0.0009 -f_cyan_ilr_2 -0.1598 0.0690 0.1770 0.0002 -0.0007 -f_JCZ38_qlogis 0.0966 -0.1132 -0.0440 0.0182 -0.1385 -0.4583 -f_JSE76_qlogis -0.0647 0.1157 0.0333 -0.0026 0.1110 0.3620 -0.8586 -log_alpha -0.0389 0.0113 0.0209 0.0021 0.0041 0.0451 -0.0605 0.0412 -log_beta -0.2508 0.0533 0.0977 0.0098 0.0220 0.2741 -0.2934 0.1999 - log_lph -log_k_JCZ38 -log_k_J9Z38 -log_k_JSE76 -f_cyan_ilr_1 -f_cyan_ilr_2 -f_JCZ38_qlogis -f_JSE76_qlogis -log_alpha -log_beta 0.2281 - -Random effects: - est. lower upper -SD.cyan_0 2.7081 0.64216 4.7740 -SD.log_k_JCZ38 0.7043 0.19951 1.2091 -SD.log_k_J9Z38 0.6248 0.05790 1.1918 -SD.log_k_JSE76 1.0750 0.33157 1.8184 -SD.f_cyan_ilr_1 0.3429 0.11688 0.5689 -SD.f_cyan_ilr_2 0.4774 0.09381 0.8610 -SD.f_JCZ38_qlogis 1.5565 -7.83970 10.9528 -SD.f_JSE76_qlogis 1.6871 -1.25577 4.6300 -SD.log_alpha 0.4216 0.15913 0.6840 - -Variance model: - est. lower upper -a.1 2.901 2.699 3.102 - -Backtransformed parameters: - est. lower upper -cyan_0 101.95862 99.220240 1.047e+02 -k_JCZ38 0.08323 0.041727 1.660e-01 -k_J9Z38 0.00455 0.002269 9.124e-03 -k_JSE76 0.04419 0.016098 1.213e-01 -f_cyan_to_JCZ38 0.61318 NA NA -f_cyan_to_J9Z38 0.21630 NA NA -f_JCZ38_to_JSE76 0.99259 0.009193 1.000e+00 -f_JSE76_to_JCZ38 0.98795 0.264857 9.999e-01 -alpha 0.73924 0.505281 1.082e+00 -beta 15.54568 13.193194 1.832e+01 - -Resulting formation fractions: - ff -cyan_JCZ38 0.613182 -cyan_J9Z38 0.216298 -cyan_sink 0.170519 -JCZ38_JSE76 0.992586 -JCZ38_sink 0.007414 -JSE76_JCZ38 0.987950 -JSE76_sink 0.012050 - -Estimated disappearance times: - DT50 DT90 DT50back -cyan 24.157 334.68 100.7 -JCZ38 8.328 27.66 NA -J9Z38 152.341 506.06 NA -JSE76 15.687 52.11 NA - -</code></pre> -<p></p> -<caption> -Hierarchical FOMC path 2 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:45:39 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_JCZ38 * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 505.619 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.9028 -1.9055 -5.0249 -2.5646 0.6807 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta - 4.8883 16.0676 9.3923 -0.1346 3.0364 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 6.321 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 1.392 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.561 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 3.614 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6339 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_alpha 0.000 0.000 0.000 0.000 0.0000 -log_beta 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta -cyan_0 0.00 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.00 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.00 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 10.41 0.00 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.00 12.24 0.00 0.0000 0.0000 -f_JSE76_qlogis 0.00 0.00 15.13 0.0000 0.0000 -log_alpha 0.00 0.00 0.00 0.3701 0.0000 -log_beta 0.00 0.00 0.00 0.0000 0.5662 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2248 2240 -1103 - -Optimised parameters: - est. lower upper -cyan_0 101.55545 9.920e+01 1.039e+02 -log_k_JCZ38 -2.37354 -2.928e+00 -1.819e+00 -log_k_J9Z38 -5.14736 -5.960e+00 -4.335e+00 -log_k_JSE76 -3.07802 -4.243e+00 -1.913e+00 -f_cyan_ilr_1 0.71263 3.655e-01 1.060e+00 -f_cyan_ilr_2 0.95202 2.701e-01 1.634e+00 -f_JCZ38_qlogis 3.58473 1.251e+00 5.919e+00 -f_JSE76_qlogis 19.03623 -1.037e+07 1.037e+07 -log_alpha -0.15297 -4.490e-01 1.431e-01 -log_beta 2.99230 2.706e+00 3.278e+00 -a.1 2.04816 NA NA -b.1 0.06886 NA NA -SD.log_k_JCZ38 0.56174 NA NA -SD.log_k_J9Z38 0.86509 NA NA -SD.log_k_JSE76 1.28450 NA NA -SD.f_cyan_ilr_1 0.38705 NA NA -SD.f_cyan_ilr_2 0.54153 NA NA -SD.f_JCZ38_qlogis 1.65311 NA NA -SD.f_JSE76_qlogis 7.51468 NA NA -SD.log_alpha 0.31586 NA NA -SD.log_beta 0.24696 NA NA - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 0.5617 NA NA -SD.log_k_J9Z38 0.8651 NA NA -SD.log_k_JSE76 1.2845 NA NA -SD.f_cyan_ilr_1 0.3870 NA NA -SD.f_cyan_ilr_2 0.5415 NA NA -SD.f_JCZ38_qlogis 1.6531 NA NA -SD.f_JSE76_qlogis 7.5147 NA NA -SD.log_alpha 0.3159 NA NA -SD.log_beta 0.2470 NA NA - -Variance model: - est. lower upper -a.1 2.04816 NA NA -b.1 0.06886 NA NA - -Backtransformed parameters: - est. lower upper -cyan_0 1.016e+02 99.20301 103.9079 -k_JCZ38 9.315e-02 0.05349 0.1622 -k_J9Z38 5.815e-03 0.00258 0.0131 -k_JSE76 4.605e-02 0.01436 0.1477 -f_cyan_to_JCZ38 6.438e-01 NA NA -f_cyan_to_J9Z38 2.350e-01 NA NA -f_JCZ38_to_JSE76 9.730e-01 0.77745 0.9973 -f_JSE76_to_JCZ38 1.000e+00 0.00000 1.0000 -alpha 8.582e-01 0.63824 1.1538 -beta 1.993e+01 14.97621 26.5262 - -Resulting formation fractions: - ff -cyan_JCZ38 6.438e-01 -cyan_J9Z38 2.350e-01 -cyan_sink 1.212e-01 -JCZ38_JSE76 9.730e-01 -JCZ38_sink 2.700e-02 -JSE76_JCZ38 1.000e+00 -JSE76_sink 5.403e-09 - -Estimated disappearance times: - DT50 DT90 DT50back -cyan 24.771 271.70 81.79 -JCZ38 7.441 24.72 NA -J9Z38 119.205 395.99 NA -JSE76 15.052 50.00 NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 2 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:46:46 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 + - f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 572.382 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 102.4358 -2.3107 -5.3123 -3.7120 0.6753 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 - 1.1462 12.4095 12.3630 -1.9317 -4.4557 - g_qlogis - -0.5648 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 4.594 0.0000 0.000 0.0 0.0000 -log_k_JCZ38 0.000 0.7966 0.000 0.0 0.0000 -log_k_J9Z38 0.000 0.0000 1.561 0.0 0.0000 -log_k_JSE76 0.000 0.0000 0.000 0.8 0.0000 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0 0.6349 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0 0.0000 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0 0.0000 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0 0.0000 -log_k1 0.000 0.0000 0.000 0.0 0.0000 -log_k2 0.000 0.0000 0.000 0.0 0.0000 -g_qlogis 0.000 0.0000 0.000 0.0 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 -cyan_0 0.000 0.00 0.0 0.000 0.0000 -log_k_JCZ38 0.000 0.00 0.0 0.000 0.0000 -log_k_J9Z38 0.000 0.00 0.0 0.000 0.0000 -log_k_JSE76 0.000 0.00 0.0 0.000 0.0000 -f_cyan_ilr_1 0.000 0.00 0.0 0.000 0.0000 -f_cyan_ilr_2 1.797 0.00 0.0 0.000 0.0000 -f_JCZ38_qlogis 0.000 13.85 0.0 0.000 0.0000 -f_JSE76_qlogis 0.000 0.00 14.1 0.000 0.0000 -log_k1 0.000 0.00 0.0 1.106 0.0000 -log_k2 0.000 0.00 0.0 0.000 0.6141 -g_qlogis 0.000 0.00 0.0 0.000 0.0000 - g_qlogis -cyan_0 0.000 -log_k_JCZ38 0.000 -log_k_J9Z38 0.000 -log_k_JSE76 0.000 -f_cyan_ilr_1 0.000 -f_cyan_ilr_2 0.000 -f_JCZ38_qlogis 0.000 -f_JSE76_qlogis 0.000 -log_k1 0.000 -log_k2 0.000 -g_qlogis 1.595 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2290 2281 -1123 - -Optimised parameters: - est. lower upper -cyan_0 102.6903 101.44420 103.9365 -log_k_JCZ38 -2.4018 -2.98058 -1.8230 -log_k_J9Z38 -5.1865 -5.92931 -4.4437 -log_k_JSE76 -3.0784 -4.25226 -1.9045 -f_cyan_ilr_1 0.7157 0.37625 1.0551 -f_cyan_ilr_2 0.7073 0.20136 1.2132 -f_JCZ38_qlogis 4.6797 0.43240 8.9269 -f_JSE76_qlogis 5.0080 -1.01380 11.0299 -log_k1 -1.9620 -2.62909 -1.2949 -log_k2 -4.4894 -4.94958 -4.0292 -g_qlogis -0.4658 -1.34443 0.4129 -a.1 2.7158 2.52576 2.9059 -SD.log_k_JCZ38 0.5818 0.15679 1.0067 -SD.log_k_J9Z38 0.7421 0.16751 1.3167 -SD.log_k_JSE76 1.2841 0.43247 2.1356 -SD.f_cyan_ilr_1 0.3748 0.13040 0.6192 -SD.f_cyan_ilr_2 0.4550 0.08396 0.8261 -SD.f_JCZ38_qlogis 2.0862 -0.73390 4.9062 -SD.f_JSE76_qlogis 1.9585 -3.14773 7.0647 -SD.log_k1 0.7389 0.25761 1.2201 -SD.log_k2 0.5132 0.18143 0.8450 -SD.g_qlogis 0.9870 0.35773 1.6164 - -Correlation: - cyan_0 l__JCZ3 l__J9Z3 l__JSE7 f_cy__1 f_cy__2 f_JCZ38 f_JSE76 -log_k_JCZ38 -0.0170 -log_k_J9Z38 -0.0457 0.0016 -log_k_JSE76 -0.0046 0.1183 0.0005 -f_cyan_ilr_1 0.0079 0.0072 -0.0909 0.0003 -f_cyan_ilr_2 -0.3114 0.0343 0.1542 0.0023 -0.0519 -f_JCZ38_qlogis 0.0777 -0.0601 -0.0152 0.0080 -0.0520 -0.2524 -f_JSE76_qlogis -0.0356 0.0817 0.0073 0.0051 0.0388 0.1959 -0.6236 -log_k1 0.0848 -0.0028 0.0010 -0.0010 -0.0014 -0.0245 0.0121 -0.0177 -log_k2 0.0274 -0.0001 0.0075 0.0000 -0.0023 -0.0060 0.0000 -0.0130 -g_qlogis 0.0159 0.0002 -0.0095 0.0002 0.0029 -0.0140 -0.0001 0.0149 - log_k1 log_k2 -log_k_JCZ38 -log_k_J9Z38 -log_k_JSE76 -f_cyan_ilr_1 -f_cyan_ilr_2 -f_JCZ38_qlogis -f_JSE76_qlogis -log_k1 -log_k2 0.0280 -g_qlogis -0.0278 -0.0310 - -Random effects: - est. lower upper -SD.log_k_JCZ38 0.5818 0.15679 1.0067 -SD.log_k_J9Z38 0.7421 0.16751 1.3167 -SD.log_k_JSE76 1.2841 0.43247 2.1356 -SD.f_cyan_ilr_1 0.3748 0.13040 0.6192 -SD.f_cyan_ilr_2 0.4550 0.08396 0.8261 -SD.f_JCZ38_qlogis 2.0862 -0.73390 4.9062 -SD.f_JSE76_qlogis 1.9585 -3.14773 7.0647 -SD.log_k1 0.7389 0.25761 1.2201 -SD.log_k2 0.5132 0.18143 0.8450 -SD.g_qlogis 0.9870 0.35773 1.6164 - -Variance model: - est. lower upper -a.1 2.716 2.526 2.906 - -Backtransformed parameters: - est. lower upper -cyan_0 1.027e+02 1.014e+02 103.93649 -k_JCZ38 9.056e-02 5.076e-02 0.16154 -k_J9Z38 5.591e-03 2.660e-03 0.01175 -k_JSE76 4.603e-02 1.423e-02 0.14890 -f_cyan_to_JCZ38 6.184e-01 NA NA -f_cyan_to_J9Z38 2.248e-01 NA NA -f_JCZ38_to_JSE76 9.908e-01 6.064e-01 0.99987 -f_JSE76_to_JCZ38 9.934e-01 2.662e-01 0.99998 -k1 1.406e-01 7.214e-02 0.27393 -k2 1.123e-02 7.086e-03 0.01779 -g 3.856e-01 2.068e-01 0.60177 - -Resulting formation fractions: - ff -cyan_JCZ38 0.618443 -cyan_J9Z38 0.224770 -cyan_sink 0.156787 -JCZ38_JSE76 0.990803 -JCZ38_sink 0.009197 -JSE76_JCZ38 0.993360 -JSE76_sink 0.006640 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 21.674 161.70 48.68 4.931 61.74 -JCZ38 7.654 25.43 NA NA NA -J9Z38 123.966 411.81 NA NA NA -JSE76 15.057 50.02 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 2 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:49:18 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 + - f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 724.515 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.7523 -1.5948 -5.0119 -2.2723 0.6719 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 - 5.1681 12.8238 12.4130 -2.0057 -4.5526 - g_qlogis - -0.5805 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.627 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 2.327 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.664 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 4.566 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6519 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_k1 0.000 0.000 0.000 0.000 0.0000 -log_k2 0.000 0.000 0.000 0.000 0.0000 -g_qlogis 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 -cyan_0 0.0 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.0 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.0 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.0 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.0 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 10.1 0.00 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.0 13.99 0.00 0.0000 0.0000 -f_JSE76_qlogis 0.0 0.00 14.15 0.0000 0.0000 -log_k1 0.0 0.00 0.00 0.8452 0.0000 -log_k2 0.0 0.00 0.00 0.0000 0.5968 -g_qlogis 0.0 0.00 0.00 0.0000 0.0000 - g_qlogis -cyan_0 0.000 -log_k_JCZ38 0.000 -log_k_J9Z38 0.000 -log_k_JSE76 0.000 -f_cyan_ilr_1 0.000 -f_cyan_ilr_2 0.000 -f_JCZ38_qlogis 0.000 -f_JSE76_qlogis 0.000 -log_k1 0.000 -log_k2 0.000 -g_qlogis 1.691 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2234 2226 -1095 - -Optimised parameters: - est. lower upper -cyan_0 101.10667 9.903e+01 103.18265 -log_k_JCZ38 -2.49437 -3.297e+00 -1.69221 -log_k_J9Z38 -5.08171 -5.875e+00 -4.28846 -log_k_JSE76 -3.20072 -4.180e+00 -2.22163 -f_cyan_ilr_1 0.71059 3.639e-01 1.05727 -f_cyan_ilr_2 1.15398 2.981e-01 2.00984 -f_JCZ38_qlogis 3.18027 1.056e+00 5.30452 -f_JSE76_qlogis 5.61578 -2.505e+01 36.28077 -log_k1 -2.38875 -2.517e+00 -2.26045 -log_k2 -4.67246 -4.928e+00 -4.41715 -g_qlogis -0.28231 -1.135e+00 0.57058 -a.1 2.08190 1.856e+00 2.30785 -b.1 0.06114 5.015e-02 0.07214 -SD.log_k_JCZ38 0.84622 2.637e-01 1.42873 -SD.log_k_J9Z38 0.84564 2.566e-01 1.43464 -SD.log_k_JSE76 1.04385 3.242e-01 1.76351 -SD.f_cyan_ilr_1 0.38568 1.362e-01 0.63514 -SD.f_cyan_ilr_2 0.68046 7.166e-02 1.28925 -SD.f_JCZ38_qlogis 1.25244 -4.213e-02 2.54700 -SD.f_JSE76_qlogis 0.28202 -1.515e+03 1515.87968 -SD.log_k2 0.25749 7.655e-02 0.43843 -SD.g_qlogis 0.94535 3.490e-01 1.54174 - -Correlation: - cyan_0 l__JCZ3 l__J9Z3 l__JSE7 f_cy__1 f_cy__2 f_JCZ38 f_JSE76 -log_k_JCZ38 -0.0086 -log_k_J9Z38 -0.0363 -0.0007 -log_k_JSE76 0.0015 0.1210 -0.0017 -f_cyan_ilr_1 -0.0048 0.0095 -0.0572 0.0030 -f_cyan_ilr_2 -0.4788 0.0328 0.1143 0.0027 -0.0316 -f_JCZ38_qlogis 0.0736 -0.0664 -0.0137 0.0145 -0.0444 -0.2175 -f_JSE76_qlogis -0.0137 0.0971 0.0035 0.0009 0.0293 0.1333 -0.6767 -log_k1 0.2345 -0.0350 -0.0099 -0.0113 -0.0126 -0.1652 0.1756 -0.2161 -log_k2 0.0440 -0.0133 0.0199 -0.0040 -0.0097 -0.0119 0.0604 -0.1306 -g_qlogis 0.0438 0.0078 -0.0123 0.0029 0.0046 -0.0363 -0.0318 0.0736 - log_k1 log_k2 -log_k_JCZ38 -log_k_J9Z38 -log_k_JSE76 -f_cyan_ilr_1 -f_cyan_ilr_2 -f_JCZ38_qlogis -f_JSE76_qlogis -log_k1 -log_k2 0.3198 -g_qlogis -0.1666 -0.0954 - -Random effects: - est. lower upper -SD.log_k_JCZ38 0.8462 2.637e-01 1.4287 -SD.log_k_J9Z38 0.8456 2.566e-01 1.4346 -SD.log_k_JSE76 1.0439 3.242e-01 1.7635 -SD.f_cyan_ilr_1 0.3857 1.362e-01 0.6351 -SD.f_cyan_ilr_2 0.6805 7.166e-02 1.2893 -SD.f_JCZ38_qlogis 1.2524 -4.213e-02 2.5470 -SD.f_JSE76_qlogis 0.2820 -1.515e+03 1515.8797 -SD.log_k2 0.2575 7.655e-02 0.4384 -SD.g_qlogis 0.9453 3.490e-01 1.5417 - -Variance model: - est. lower upper -a.1 2.08190 1.85595 2.30785 -b.1 0.06114 0.05015 0.07214 - -Backtransformed parameters: - est. lower upper -cyan_0 1.011e+02 9.903e+01 103.18265 -k_JCZ38 8.255e-02 3.701e-02 0.18411 -k_J9Z38 6.209e-03 2.809e-03 0.01373 -k_JSE76 4.073e-02 1.530e-02 0.10843 -f_cyan_to_JCZ38 6.608e-01 NA NA -f_cyan_to_J9Z38 2.419e-01 NA NA -f_JCZ38_to_JSE76 9.601e-01 7.419e-01 0.99506 -f_JSE76_to_JCZ38 9.964e-01 1.322e-11 1.00000 -k1 9.174e-02 8.070e-02 0.10430 -k2 9.349e-03 7.243e-03 0.01207 -g 4.299e-01 2.432e-01 0.63890 - -Resulting formation fractions: - ff -cyan_JCZ38 0.660808 -cyan_J9Z38 0.241904 -cyan_sink 0.097288 -JCZ38_JSE76 0.960085 -JCZ38_sink 0.039915 -JSE76_JCZ38 0.996373 -JSE76_sink 0.003627 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 24.359 186.18 56.05 7.555 74.14 -JCZ38 8.397 27.89 NA NA NA -J9Z38 111.631 370.83 NA NA NA -JSE76 17.017 56.53 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 2 fit with constant variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:46:33 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 559.097 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 102.4394 -2.7673 -2.8942 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.6201 -2.3107 -5.3123 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -3.7120 0.6754 1.1448 - f_JCZ38_qlogis f_JSE76_qlogis - 13.2672 13.3538 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 4.589 0.0000 0.00 -log_k_cyan_free 0.000 0.4849 0.00 -log_k_cyan_free_bound 0.000 0.0000 1.62 -log_k_cyan_bound_free 0.000 0.0000 0.00 -log_k_JCZ38 0.000 0.0000 0.00 -log_k_J9Z38 0.000 0.0000 0.00 -log_k_JSE76 0.000 0.0000 0.00 -f_cyan_ilr_1 0.000 0.0000 0.00 -f_cyan_ilr_2 0.000 0.0000 0.00 -f_JCZ38_qlogis 0.000 0.0000 0.00 -f_JSE76_qlogis 0.000 0.0000 0.00 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.0000 0.000 0.0 -log_k_cyan_free 0.000 0.0000 0.000 0.0 -log_k_cyan_free_bound 0.000 0.0000 0.000 0.0 -log_k_cyan_bound_free 1.197 0.0000 0.000 0.0 -log_k_JCZ38 0.000 0.7966 0.000 0.0 -log_k_J9Z38 0.000 0.0000 1.561 0.0 -log_k_JSE76 0.000 0.0000 0.000 0.8 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis -cyan_free_0 0.0000 0.000 0.00 0.00 -log_k_cyan_free 0.0000 0.000 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.000 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.000 0.00 0.00 -log_k_JCZ38 0.0000 0.000 0.00 0.00 -log_k_J9Z38 0.0000 0.000 0.00 0.00 -log_k_JSE76 0.0000 0.000 0.00 0.00 -f_cyan_ilr_1 0.6349 0.000 0.00 0.00 -f_cyan_ilr_2 0.0000 1.797 0.00 0.00 -f_JCZ38_qlogis 0.0000 0.000 13.84 0.00 -f_JSE76_qlogis 0.0000 0.000 0.00 14.66 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2284 2275 -1120 - -Optimised parameters: - est. lower upper -cyan_free_0 102.7730 1.015e+02 1.041e+02 -log_k_cyan_free -2.8530 -3.167e+00 -2.539e+00 -log_k_cyan_free_bound -2.7326 -3.543e+00 -1.922e+00 -log_k_cyan_bound_free -3.5582 -4.126e+00 -2.990e+00 -log_k_JCZ38 -2.3810 -2.921e+00 -1.841e+00 -log_k_J9Z38 -5.2301 -5.963e+00 -4.497e+00 -log_k_JSE76 -3.0286 -4.286e+00 -1.771e+00 -f_cyan_ilr_1 0.7081 3.733e-01 1.043e+00 -f_cyan_ilr_2 0.5847 7.846e-03 1.162e+00 -f_JCZ38_qlogis 9.5676 -1.323e+03 1.342e+03 -f_JSE76_qlogis 3.7042 7.254e-02 7.336e+00 -a.1 2.7222 2.532e+00 2.913e+00 -SD.log_k_cyan_free 0.3338 1.086e-01 5.589e-01 -SD.log_k_cyan_free_bound 0.8888 3.023e-01 1.475e+00 -SD.log_k_cyan_bound_free 0.6220 2.063e-01 1.038e+00 -SD.log_k_JCZ38 0.5221 1.334e-01 9.108e-01 -SD.log_k_J9Z38 0.7104 1.371e-01 1.284e+00 -SD.log_k_JSE76 1.3837 4.753e-01 2.292e+00 -SD.f_cyan_ilr_1 0.3620 1.248e-01 5.992e-01 -SD.f_cyan_ilr_2 0.4259 8.145e-02 7.704e-01 -SD.f_JCZ38_qlogis 3.5332 -1.037e+05 1.037e+05 -SD.f_JSE76_qlogis 1.6990 -2.771e-01 3.675e+00 - -Correlation: - cyn_f_0 lg_k_c_ lg_k_cyn_f_ lg_k_cyn_b_ l__JCZ3 l__J9Z3 -log_k_cyan_free 0.2126 -log_k_cyan_free_bound 0.0894 0.0871 -log_k_cyan_bound_free 0.0033 0.0410 0.0583 -log_k_JCZ38 -0.0708 -0.0280 -0.0147 0.0019 -log_k_J9Z38 -0.0535 -0.0138 0.0012 0.0148 0.0085 -log_k_JSE76 -0.0066 -0.0030 -0.0021 -0.0005 0.1090 0.0010 -f_cyan_ilr_1 -0.0364 -0.0157 -0.0095 -0.0015 0.0458 -0.0960 -f_cyan_ilr_2 -0.3814 -0.1104 -0.0423 0.0146 0.1540 0.1526 -f_JCZ38_qlogis 0.2507 0.0969 0.0482 -0.0097 -0.2282 -0.0363 -f_JSE76_qlogis -0.1648 -0.0710 -0.0443 -0.0087 0.2002 0.0226 - l__JSE7 f_cy__1 f_cy__2 f_JCZ38 -log_k_cyan_free -log_k_cyan_free_bound -log_k_cyan_bound_free -log_k_JCZ38 -log_k_J9Z38 -log_k_JSE76 -f_cyan_ilr_1 0.0001 -f_cyan_ilr_2 0.0031 0.0586 -f_JCZ38_qlogis 0.0023 -0.1867 -0.6255 -f_JSE76_qlogis 0.0082 0.1356 0.4519 -0.7951 - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.3338 1.086e-01 5.589e-01 -SD.log_k_cyan_free_bound 0.8888 3.023e-01 1.475e+00 -SD.log_k_cyan_bound_free 0.6220 2.063e-01 1.038e+00 -SD.log_k_JCZ38 0.5221 1.334e-01 9.108e-01 -SD.log_k_J9Z38 0.7104 1.371e-01 1.284e+00 -SD.log_k_JSE76 1.3837 4.753e-01 2.292e+00 -SD.f_cyan_ilr_1 0.3620 1.248e-01 5.992e-01 -SD.f_cyan_ilr_2 0.4259 8.145e-02 7.704e-01 -SD.f_JCZ38_qlogis 3.5332 -1.037e+05 1.037e+05 -SD.f_JSE76_qlogis 1.6990 -2.771e-01 3.675e+00 - -Variance model: - est. lower upper -a.1 2.722 2.532 2.913 - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.028e+02 1.015e+02 104.06475 -k_cyan_free 5.767e-02 4.213e-02 0.07894 -k_cyan_free_bound 6.505e-02 2.892e-02 0.14633 -k_cyan_bound_free 2.849e-02 1.614e-02 0.05028 -k_JCZ38 9.246e-02 5.390e-02 0.15859 -k_J9Z38 5.353e-03 2.572e-03 0.01114 -k_JSE76 4.838e-02 1.376e-02 0.17009 -f_cyan_free_to_JCZ38 6.011e-01 5.028e-01 0.83792 -f_cyan_free_to_J9Z38 2.208e-01 5.028e-01 0.83792 -f_JCZ38_to_JSE76 9.999e-01 0.000e+00 1.00000 -f_JSE76_to_JCZ38 9.760e-01 5.181e-01 0.99935 - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g -0.13942 0.01178 0.35948 - -Resulting formation fractions: - ff -cyan_free_JCZ38 6.011e-01 -cyan_free_J9Z38 2.208e-01 -cyan_free_sink 1.780e-01 -cyan_free 1.000e+00 -JCZ38_JSE76 9.999e-01 -JCZ38_sink 6.996e-05 -JSE76_JCZ38 9.760e-01 -JSE76_sink 2.403e-02 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 23.390 157.60 47.44 4.971 58.82 -JCZ38 7.497 24.90 NA NA NA -J9Z38 129.482 430.13 NA NA NA -JSE76 14.326 47.59 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 2 fit with two-component error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 20:49:20 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 726.293 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 101.751 -2.837 -3.016 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.660 -2.299 -5.313 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -3.699 0.672 5.873 - f_JCZ38_qlogis f_JSE76_qlogis - 13.216 13.338 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 5.629 0.000 0.000 -log_k_cyan_free 0.000 0.446 0.000 -log_k_cyan_free_bound 0.000 0.000 1.449 -log_k_cyan_bound_free 0.000 0.000 0.000 -log_k_JCZ38 0.000 0.000 0.000 -log_k_J9Z38 0.000 0.000 0.000 -log_k_JSE76 0.000 0.000 0.000 -f_cyan_ilr_1 0.000 0.000 0.000 -f_cyan_ilr_2 0.000 0.000 0.000 -f_JCZ38_qlogis 0.000 0.000 0.000 -f_JSE76_qlogis 0.000 0.000 0.000 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.0000 0.000 0.0000 -log_k_cyan_free 0.000 0.0000 0.000 0.0000 -log_k_cyan_free_bound 0.000 0.0000 0.000 0.0000 -log_k_cyan_bound_free 1.213 0.0000 0.000 0.0000 -log_k_JCZ38 0.000 0.7801 0.000 0.0000 -log_k_J9Z38 0.000 0.0000 1.575 0.0000 -log_k_JSE76 0.000 0.0000 0.000 0.8078 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0000 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis -cyan_free_0 0.0000 0.00 0.00 0.00 -log_k_cyan_free 0.0000 0.00 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.00 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.00 0.00 0.00 -log_k_JCZ38 0.0000 0.00 0.00 0.00 -log_k_J9Z38 0.0000 0.00 0.00 0.00 -log_k_JSE76 0.0000 0.00 0.00 0.00 -f_cyan_ilr_1 0.6519 0.00 0.00 0.00 -f_cyan_ilr_2 0.0000 10.78 0.00 0.00 -f_JCZ38_qlogis 0.0000 0.00 13.96 0.00 -f_JSE76_qlogis 0.0000 0.00 0.00 14.69 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2240 2232 -1098 - -Optimised parameters: - est. lower upper -cyan_free_0 101.10205 98.99221 103.2119 -log_k_cyan_free -3.16929 -3.61395 -2.7246 -log_k_cyan_free_bound -3.38259 -3.63022 -3.1350 -log_k_cyan_bound_free -3.81075 -4.13888 -3.4826 -log_k_JCZ38 -2.42057 -3.00756 -1.8336 -log_k_J9Z38 -5.07501 -5.85138 -4.2986 -log_k_JSE76 -3.12442 -4.21277 -2.0361 -f_cyan_ilr_1 0.70577 0.35788 1.0537 -f_cyan_ilr_2 1.14824 0.15810 2.1384 -f_JCZ38_qlogis 3.52245 0.43257 6.6123 -f_JSE76_qlogis 5.65140 -21.22295 32.5257 -a.1 2.07062 1.84329 2.2980 -b.1 0.06227 0.05124 0.0733 -SD.log_k_cyan_free 0.49468 0.18566 0.8037 -SD.log_k_cyan_bound_free 0.28972 0.07188 0.5076 -SD.log_k_JCZ38 0.58852 0.16800 1.0090 -SD.log_k_J9Z38 0.82500 0.24730 1.4027 -SD.log_k_JSE76 1.19201 0.40313 1.9809 -SD.f_cyan_ilr_1 0.38534 0.13640 0.6343 -SD.f_cyan_ilr_2 0.72463 0.10076 1.3485 -SD.f_JCZ38_qlogis 1.38223 -0.20997 2.9744 -SD.f_JSE76_qlogis 2.07989 -72.53027 76.6901 - -Correlation: - cyn_f_0 lg_k_c_ lg_k_cyn_f_ lg_k_cyn_b_ l__JCZ3 l__J9Z3 -log_k_cyan_free 0.1117 -log_k_cyan_free_bound 0.1763 0.1828 -log_k_cyan_bound_free 0.0120 0.0593 0.5030 -log_k_JCZ38 -0.0459 -0.0230 -0.0931 -0.0337 -log_k_J9Z38 -0.0381 -0.0123 -0.0139 0.0237 0.0063 -log_k_JSE76 -0.0044 -0.0038 -0.0175 -0.0072 0.1120 0.0003 -f_cyan_ilr_1 -0.0199 -0.0087 -0.0407 -0.0233 0.0268 -0.0552 -f_cyan_ilr_2 -0.4806 -0.1015 -0.2291 -0.0269 0.1156 0.1113 -f_JCZ38_qlogis 0.1805 0.0825 0.3085 0.0963 -0.1674 -0.0314 -f_JSE76_qlogis -0.1586 -0.0810 -0.3560 -0.1563 0.2025 0.0278 - l__JSE7 f_cy__1 f_cy__2 f_JCZ38 -log_k_cyan_free -log_k_cyan_free_bound -log_k_cyan_bound_free -log_k_JCZ38 -log_k_J9Z38 -log_k_JSE76 -f_cyan_ilr_1 0.0024 -f_cyan_ilr_2 0.0087 0.0172 -f_JCZ38_qlogis -0.0016 -0.1047 -0.4656 -f_JSE76_qlogis 0.0119 0.1034 0.4584 -0.8137 - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.4947 0.18566 0.8037 -SD.log_k_cyan_bound_free 0.2897 0.07188 0.5076 -SD.log_k_JCZ38 0.5885 0.16800 1.0090 -SD.log_k_J9Z38 0.8250 0.24730 1.4027 -SD.log_k_JSE76 1.1920 0.40313 1.9809 -SD.f_cyan_ilr_1 0.3853 0.13640 0.6343 -SD.f_cyan_ilr_2 0.7246 0.10076 1.3485 -SD.f_JCZ38_qlogis 1.3822 -0.20997 2.9744 -SD.f_JSE76_qlogis 2.0799 -72.53027 76.6901 - -Variance model: - est. lower upper -a.1 2.07062 1.84329 2.2980 -b.1 0.06227 0.05124 0.0733 - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.011e+02 9.899e+01 103.21190 -k_cyan_free 4.203e-02 2.695e-02 0.06557 -k_cyan_free_bound 3.396e-02 2.651e-02 0.04350 -k_cyan_bound_free 2.213e-02 1.594e-02 0.03073 -k_JCZ38 8.887e-02 4.941e-02 0.15984 -k_J9Z38 6.251e-03 2.876e-03 0.01359 -k_JSE76 4.396e-02 1.481e-02 0.13054 -f_cyan_free_to_JCZ38 6.590e-01 5.557e-01 0.95365 -f_cyan_free_to_J9Z38 2.429e-01 5.557e-01 0.95365 -f_JCZ38_to_JSE76 9.713e-01 6.065e-01 0.99866 -f_JSE76_to_JCZ38 9.965e-01 6.067e-10 1.00000 - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g -0.08749 0.01063 0.40855 - -Resulting formation fractions: - ff -cyan_free_JCZ38 0.65905 -cyan_free_J9Z38 0.24291 -cyan_free_sink 0.09805 -cyan_free 1.00000 -JCZ38_JSE76 0.97132 -JCZ38_sink 0.02868 -JSE76_JCZ38 0.99650 -JSE76_sink 0.00350 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 24.91 167.16 50.32 7.922 65.19 -JCZ38 7.80 25.91 NA NA NA -J9Z38 110.89 368.36 NA NA NA -JSE76 15.77 52.38 NA NA NA - -</code></pre> -<p></p> -</div> -<div class="section level4"> -<h4 id="pathway-2-refined-fits">Pathway 2, refined fits<a class="anchor" aria-label="anchor" href="#pathway-2-refined-fits"></a> -</h4> -<caption> -Hierarchical FOMC path 2 fit with reduced random effects, two-component -error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 21:02:39 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - (alpha/beta) * 1/((time/beta) + 1) * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_JCZ38 * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * (alpha/beta) * 1/((time/beta) + 1) * - cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 796.615 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.9028 -1.9055 -5.0249 -2.5646 0.6807 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta - 4.8883 16.0676 9.3923 -0.1346 3.0364 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 6.321 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 1.392 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.561 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 3.614 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6339 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_alpha 0.000 0.000 0.000 0.000 0.0000 -log_beta 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_alpha log_beta -cyan_0 0.00 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.00 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.00 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.00 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 10.41 0.00 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.00 12.24 0.00 0.0000 0.0000 -f_JSE76_qlogis 0.00 0.00 15.13 0.0000 0.0000 -log_alpha 0.00 0.00 0.00 0.3701 0.0000 -log_beta 0.00 0.00 0.00 0.0000 0.5662 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2251 2244 -1106 - -Optimised parameters: - est. lower upper -cyan_0 101.05768 NA NA -log_k_JCZ38 -2.73252 NA NA -log_k_J9Z38 -5.07399 NA NA -log_k_JSE76 -3.52863 NA NA -f_cyan_ilr_1 0.72176 NA NA -f_cyan_ilr_2 1.34610 NA NA -f_JCZ38_qlogis 2.08337 NA NA -f_JSE76_qlogis 1590.31880 NA NA -log_alpha -0.09336 NA NA -log_beta 3.10191 NA NA -a.1 2.08557 1.85439 2.31675 -b.1 0.06998 0.05800 0.08197 -SD.log_k_JCZ38 1.20053 0.43329 1.96777 -SD.log_k_J9Z38 0.85854 0.26708 1.45000 -SD.log_k_JSE76 0.62528 0.16061 1.08995 -SD.f_cyan_ilr_1 0.35190 0.12340 0.58039 -SD.f_cyan_ilr_2 0.85385 0.15391 1.55378 -SD.log_alpha 0.28971 0.08718 0.49225 -SD.log_beta 0.31614 0.05938 0.57290 - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.2005 0.43329 1.9678 -SD.log_k_J9Z38 0.8585 0.26708 1.4500 -SD.log_k_JSE76 0.6253 0.16061 1.0900 -SD.f_cyan_ilr_1 0.3519 0.12340 0.5804 -SD.f_cyan_ilr_2 0.8538 0.15391 1.5538 -SD.log_alpha 0.2897 0.08718 0.4923 -SD.log_beta 0.3161 0.05938 0.5729 - -Variance model: - est. lower upper -a.1 2.08557 1.854 2.31675 -b.1 0.06998 0.058 0.08197 - -Backtransformed parameters: - est. lower upper -cyan_0 1.011e+02 NA NA -k_JCZ38 6.506e-02 NA NA -k_J9Z38 6.257e-03 NA NA -k_JSE76 2.935e-02 NA NA -f_cyan_to_JCZ38 6.776e-01 NA NA -f_cyan_to_J9Z38 2.442e-01 NA NA -f_JCZ38_to_JSE76 8.893e-01 NA NA -f_JSE76_to_JCZ38 1.000e+00 NA NA -alpha 9.109e-01 NA NA -beta 2.224e+01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.67761 -cyan_J9Z38 0.24417 -cyan_sink 0.07822 -JCZ38_JSE76 0.88928 -JCZ38_sink 0.11072 -JSE76_JCZ38 1.00000 -JSE76_sink 0.00000 - -Estimated disappearance times: - DT50 DT90 DT50back -cyan 25.36 256.37 77.18 -JCZ38 10.65 35.39 NA -J9Z38 110.77 367.98 NA -JSE76 23.62 78.47 NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 2 fit with reduced random effects, constant -variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 21:04:15 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 + - f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 893.328 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 102.4358 -2.3107 -5.3123 -3.7120 0.6753 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 - 1.1462 12.4095 12.3630 -1.9317 -4.4557 - g_qlogis - -0.5648 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 4.594 0.0000 0.000 0.0 0.0000 -log_k_JCZ38 0.000 0.7966 0.000 0.0 0.0000 -log_k_J9Z38 0.000 0.0000 1.561 0.0 0.0000 -log_k_JSE76 0.000 0.0000 0.000 0.8 0.0000 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0 0.6349 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0 0.0000 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0 0.0000 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0 0.0000 -log_k1 0.000 0.0000 0.000 0.0 0.0000 -log_k2 0.000 0.0000 0.000 0.0 0.0000 -g_qlogis 0.000 0.0000 0.000 0.0 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 -cyan_0 0.000 0.00 0.0 0.000 0.0000 -log_k_JCZ38 0.000 0.00 0.0 0.000 0.0000 -log_k_J9Z38 0.000 0.00 0.0 0.000 0.0000 -log_k_JSE76 0.000 0.00 0.0 0.000 0.0000 -f_cyan_ilr_1 0.000 0.00 0.0 0.000 0.0000 -f_cyan_ilr_2 1.797 0.00 0.0 0.000 0.0000 -f_JCZ38_qlogis 0.000 13.85 0.0 0.000 0.0000 -f_JSE76_qlogis 0.000 0.00 14.1 0.000 0.0000 -log_k1 0.000 0.00 0.0 1.106 0.0000 -log_k2 0.000 0.00 0.0 0.000 0.6141 -g_qlogis 0.000 0.00 0.0 0.000 0.0000 - g_qlogis -cyan_0 0.000 -log_k_JCZ38 0.000 -log_k_J9Z38 0.000 -log_k_JSE76 0.000 -f_cyan_ilr_1 0.000 -f_cyan_ilr_2 0.000 -f_JCZ38_qlogis 0.000 -f_JSE76_qlogis 0.000 -log_k1 0.000 -log_k2 0.000 -g_qlogis 1.595 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2282 2274 -1121 - -Optimised parameters: - est. lower upper -cyan_0 102.5254 NA NA -log_k_JCZ38 -2.9358 NA NA -log_k_J9Z38 -5.1424 NA NA -log_k_JSE76 -3.6458 NA NA -f_cyan_ilr_1 0.6957 NA NA -f_cyan_ilr_2 0.6635 NA NA -f_JCZ38_qlogis 4984.8163 NA NA -f_JSE76_qlogis 1.9415 NA NA -log_k1 -1.9456 NA NA -log_k2 -4.4705 NA NA -g_qlogis -0.5117 NA NA -a.1 2.7455 2.55392 2.9370 -SD.log_k_JCZ38 1.3163 0.47635 2.1563 -SD.log_k_J9Z38 0.7162 0.16133 1.2711 -SD.log_k_JSE76 0.6457 0.15249 1.1390 -SD.f_cyan_ilr_1 0.3424 0.11714 0.5677 -SD.f_cyan_ilr_2 0.4524 0.09709 0.8077 -SD.log_k1 0.7353 0.25445 1.2161 -SD.log_k2 0.5137 0.18206 0.8453 -SD.g_qlogis 0.9857 0.35651 1.6148 - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.3163 0.47635 2.1563 -SD.log_k_J9Z38 0.7162 0.16133 1.2711 -SD.log_k_JSE76 0.6457 0.15249 1.1390 -SD.f_cyan_ilr_1 0.3424 0.11714 0.5677 -SD.f_cyan_ilr_2 0.4524 0.09709 0.8077 -SD.log_k1 0.7353 0.25445 1.2161 -SD.log_k2 0.5137 0.18206 0.8453 -SD.g_qlogis 0.9857 0.35651 1.6148 - -Variance model: - est. lower upper -a.1 2.745 2.554 2.937 - -Backtransformed parameters: - est. lower upper -cyan_0 1.025e+02 NA NA -k_JCZ38 5.309e-02 NA NA -k_J9Z38 5.844e-03 NA NA -k_JSE76 2.610e-02 NA NA -f_cyan_to_JCZ38 6.079e-01 NA NA -f_cyan_to_J9Z38 2.272e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -f_JSE76_to_JCZ38 8.745e-01 NA NA -k1 1.429e-01 NA NA -k2 1.144e-02 NA NA -g 3.748e-01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.6079 -cyan_J9Z38 0.2272 -cyan_sink 0.1649 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 -JSE76_JCZ38 0.8745 -JSE76_sink 0.1255 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 22.29 160.20 48.22 4.85 60.58 -JCZ38 13.06 43.37 NA NA NA -J9Z38 118.61 394.02 NA NA NA -JSE76 26.56 88.22 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical DFOP path 2 fit with reduced random effects, two-component -error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 21:04:33 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * cyan -d_JCZ38/dt = + f_cyan_to_JCZ38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_JCZ38 * JCZ38 + - f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_to_J9Z38 * ((k1 * g * exp(-k1 * time) + k2 * (1 - - g) * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * - exp(-k2 * time))) * cyan - k_J9Z38 * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 910.788 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 - 101.7523 -1.5948 -5.0119 -2.2723 0.6719 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 - 5.1681 12.8238 12.4130 -2.0057 -4.5526 - g_qlogis - -0.5805 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_0 log_k_JCZ38 log_k_J9Z38 log_k_JSE76 f_cyan_ilr_1 -cyan_0 5.627 0.000 0.000 0.000 0.0000 -log_k_JCZ38 0.000 2.327 0.000 0.000 0.0000 -log_k_J9Z38 0.000 0.000 1.664 0.000 0.0000 -log_k_JSE76 0.000 0.000 0.000 4.566 0.0000 -f_cyan_ilr_1 0.000 0.000 0.000 0.000 0.6519 -f_cyan_ilr_2 0.000 0.000 0.000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.000 0.000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.000 0.000 0.000 0.0000 -log_k1 0.000 0.000 0.000 0.000 0.0000 -log_k2 0.000 0.000 0.000 0.000 0.0000 -g_qlogis 0.000 0.000 0.000 0.000 0.0000 - f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis log_k1 log_k2 -cyan_0 0.0 0.00 0.00 0.0000 0.0000 -log_k_JCZ38 0.0 0.00 0.00 0.0000 0.0000 -log_k_J9Z38 0.0 0.00 0.00 0.0000 0.0000 -log_k_JSE76 0.0 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_1 0.0 0.00 0.00 0.0000 0.0000 -f_cyan_ilr_2 10.1 0.00 0.00 0.0000 0.0000 -f_JCZ38_qlogis 0.0 13.99 0.00 0.0000 0.0000 -f_JSE76_qlogis 0.0 0.00 14.15 0.0000 0.0000 -log_k1 0.0 0.00 0.00 0.8452 0.0000 -log_k2 0.0 0.00 0.00 0.0000 0.5968 -g_qlogis 0.0 0.00 0.00 0.0000 0.0000 - g_qlogis -cyan_0 0.000 -log_k_JCZ38 0.000 -log_k_J9Z38 0.000 -log_k_JSE76 0.000 -f_cyan_ilr_1 0.000 -f_cyan_ilr_2 0.000 -f_JCZ38_qlogis 0.000 -f_JSE76_qlogis 0.000 -log_k1 0.000 -log_k2 0.000 -g_qlogis 1.691 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2232 2224 -1096 - -Optimised parameters: - est. lower upper -cyan_0 101.20051 NA NA -log_k_JCZ38 -2.93542 NA NA -log_k_J9Z38 -5.03151 NA NA -log_k_JSE76 -3.67679 NA NA -f_cyan_ilr_1 0.67290 NA NA -f_cyan_ilr_2 0.99787 NA NA -f_JCZ38_qlogis 348.32484 NA NA -f_JSE76_qlogis 1.87846 NA NA -log_k1 -2.32738 NA NA -log_k2 -4.61295 NA NA -g_qlogis -0.38342 NA NA -a.1 2.06184 1.83746 2.28622 -b.1 0.06329 0.05211 0.07447 -SD.log_k_JCZ38 1.29042 0.47468 2.10617 -SD.log_k_J9Z38 0.84235 0.25903 1.42566 -SD.log_k_JSE76 0.56930 0.13934 0.99926 -SD.f_cyan_ilr_1 0.35183 0.12298 0.58068 -SD.f_cyan_ilr_2 0.77269 0.17908 1.36631 -SD.log_k2 0.28549 0.09210 0.47888 -SD.g_qlogis 0.93830 0.34568 1.53093 - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_JCZ38 1.2904 0.4747 2.1062 -SD.log_k_J9Z38 0.8423 0.2590 1.4257 -SD.log_k_JSE76 0.5693 0.1393 0.9993 -SD.f_cyan_ilr_1 0.3518 0.1230 0.5807 -SD.f_cyan_ilr_2 0.7727 0.1791 1.3663 -SD.log_k2 0.2855 0.0921 0.4789 -SD.g_qlogis 0.9383 0.3457 1.5309 - -Variance model: - est. lower upper -a.1 2.06184 1.83746 2.28622 -b.1 0.06329 0.05211 0.07447 - -Backtransformed parameters: - est. lower upper -cyan_0 1.012e+02 NA NA -k_JCZ38 5.311e-02 NA NA -k_J9Z38 6.529e-03 NA NA -k_JSE76 2.530e-02 NA NA -f_cyan_to_JCZ38 6.373e-01 NA NA -f_cyan_to_J9Z38 2.461e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -f_JSE76_to_JCZ38 8.674e-01 NA NA -k1 9.755e-02 NA NA -k2 9.922e-03 NA NA -g 4.053e-01 NA NA - -Resulting formation fractions: - ff -cyan_JCZ38 0.6373 -cyan_J9Z38 0.2461 -cyan_sink 0.1167 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 -JSE76_JCZ38 0.8674 -JSE76_sink 0.1326 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -cyan 24.93 179.68 54.09 7.105 69.86 -JCZ38 13.05 43.36 NA NA NA -J9Z38 106.16 352.67 NA NA NA -JSE76 27.39 91.00 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 2 fit with reduced random effects, constant -variance -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 21:04:09 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 887.369 s -Using 300, 100 iterations and 10 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 102.4394 -2.7673 -2.8942 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.6201 -2.3107 -5.3123 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -3.7120 0.6754 1.1448 - f_JCZ38_qlogis f_JSE76_qlogis - 13.2672 13.3538 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 4.589 0.0000 0.00 -log_k_cyan_free 0.000 0.4849 0.00 -log_k_cyan_free_bound 0.000 0.0000 1.62 -log_k_cyan_bound_free 0.000 0.0000 0.00 -log_k_JCZ38 0.000 0.0000 0.00 -log_k_J9Z38 0.000 0.0000 0.00 -log_k_JSE76 0.000 0.0000 0.00 -f_cyan_ilr_1 0.000 0.0000 0.00 -f_cyan_ilr_2 0.000 0.0000 0.00 -f_JCZ38_qlogis 0.000 0.0000 0.00 -f_JSE76_qlogis 0.000 0.0000 0.00 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.0000 0.000 0.0 -log_k_cyan_free 0.000 0.0000 0.000 0.0 -log_k_cyan_free_bound 0.000 0.0000 0.000 0.0 -log_k_cyan_bound_free 1.197 0.0000 0.000 0.0 -log_k_JCZ38 0.000 0.7966 0.000 0.0 -log_k_J9Z38 0.000 0.0000 1.561 0.0 -log_k_JSE76 0.000 0.0000 0.000 0.8 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis -cyan_free_0 0.0000 0.000 0.00 0.00 -log_k_cyan_free 0.0000 0.000 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.000 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.000 0.00 0.00 -log_k_JCZ38 0.0000 0.000 0.00 0.00 -log_k_J9Z38 0.0000 0.000 0.00 0.00 -log_k_JSE76 0.0000 0.000 0.00 0.00 -f_cyan_ilr_1 0.6349 0.000 0.00 0.00 -f_cyan_ilr_2 0.0000 1.797 0.00 0.00 -f_JCZ38_qlogis 0.0000 0.000 13.84 0.00 -f_JSE76_qlogis 0.0000 0.000 0.00 14.66 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2279 2272 -1120 - -Optimised parameters: - est. lower upper -cyan_free_0 102.5621 NA NA -log_k_cyan_free -2.8531 NA NA -log_k_cyan_free_bound -2.6916 NA NA -log_k_cyan_bound_free -3.5032 NA NA -log_k_JCZ38 -2.9436 NA NA -log_k_J9Z38 -5.1140 NA NA -log_k_JSE76 -3.6472 NA NA -f_cyan_ilr_1 0.6887 NA NA -f_cyan_ilr_2 0.6874 NA NA -f_JCZ38_qlogis 4063.6389 NA NA -f_JSE76_qlogis 1.9556 NA NA -a.1 2.7460 2.55451 2.9376 -SD.log_k_cyan_free 0.3131 0.09841 0.5277 -SD.log_k_cyan_free_bound 0.8850 0.29909 1.4710 -SD.log_k_cyan_bound_free 0.6167 0.20391 1.0295 -SD.log_k_JCZ38 1.3555 0.49101 2.2200 -SD.log_k_J9Z38 0.7200 0.16166 1.2783 -SD.log_k_JSE76 0.6252 0.14619 1.1042 -SD.f_cyan_ilr_1 0.3386 0.11447 0.5627 -SD.f_cyan_ilr_2 0.4699 0.09810 0.8417 - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.3131 0.09841 0.5277 -SD.log_k_cyan_free_bound 0.8850 0.29909 1.4710 -SD.log_k_cyan_bound_free 0.6167 0.20391 1.0295 -SD.log_k_JCZ38 1.3555 0.49101 2.2200 -SD.log_k_J9Z38 0.7200 0.16166 1.2783 -SD.log_k_JSE76 0.6252 0.14619 1.1042 -SD.f_cyan_ilr_1 0.3386 0.11447 0.5627 -SD.f_cyan_ilr_2 0.4699 0.09810 0.8417 - -Variance model: - est. lower upper -a.1 2.746 2.555 2.938 - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.026e+02 NA NA -k_cyan_free 5.767e-02 NA NA -k_cyan_free_bound 6.777e-02 NA NA -k_cyan_bound_free 3.010e-02 NA NA -k_JCZ38 5.267e-02 NA NA -k_J9Z38 6.012e-03 NA NA -k_JSE76 2.606e-02 NA NA -f_cyan_free_to_JCZ38 6.089e-01 NA NA -f_cyan_free_to_J9Z38 2.299e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -f_JSE76_to_JCZ38 8.761e-01 NA NA - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g - 0.1434 0.0121 0.3469 - -Resulting formation fractions: - ff -cyan_free_JCZ38 0.6089 -cyan_free_J9Z38 0.2299 -cyan_free_sink 0.1612 -cyan_free 1.0000 -JCZ38_JSE76 1.0000 -JCZ38_sink 0.0000 -JSE76_JCZ38 0.8761 -JSE76_sink 0.1239 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 23.94 155.06 46.68 4.832 57.28 -JCZ38 13.16 43.71 NA NA NA -J9Z38 115.30 383.02 NA NA NA -JSE76 26.59 88.35 NA NA NA - -</code></pre> -<p></p> -<caption> -Hierarchical SFORB path 2 fit with reduced random effects, two-component -error -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.4 -R version used for fitting: 4.2.3 -Date of fit: Thu Apr 20 21:04:32 2023 -Date of summary: Thu Apr 20 21:04:34 2023 - -Equations: -d_cyan_free/dt = - k_cyan_free * cyan_free - k_cyan_free_bound * - cyan_free + k_cyan_bound_free * cyan_bound -d_cyan_bound/dt = + k_cyan_free_bound * cyan_free - k_cyan_bound_free * - cyan_bound -d_JCZ38/dt = + f_cyan_free_to_JCZ38 * k_cyan_free * cyan_free - k_JCZ38 - * JCZ38 + f_JSE76_to_JCZ38 * k_JSE76 * JSE76 -d_J9Z38/dt = + f_cyan_free_to_J9Z38 * k_cyan_free * cyan_free - k_J9Z38 - * J9Z38 -d_JSE76/dt = + f_JCZ38_to_JSE76 * k_JCZ38 * JCZ38 - k_JSE76 * JSE76 - -Data: -433 observations of 4 variable(s) grouped in 5 datasets - -Model predictions using solution type deSolve - -Fitted in 910.017 s -Using 300, 100 iterations and 10 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound - 101.751 -2.837 -3.016 -log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 - -3.660 -2.299 -5.313 - log_k_JSE76 f_cyan_ilr_1 f_cyan_ilr_2 - -3.699 0.672 5.873 - f_JCZ38_qlogis f_JSE76_qlogis - 13.216 13.338 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - cyan_free_0 log_k_cyan_free log_k_cyan_free_bound -cyan_free_0 5.629 0.000 0.000 -log_k_cyan_free 0.000 0.446 0.000 -log_k_cyan_free_bound 0.000 0.000 1.449 -log_k_cyan_bound_free 0.000 0.000 0.000 -log_k_JCZ38 0.000 0.000 0.000 -log_k_J9Z38 0.000 0.000 0.000 -log_k_JSE76 0.000 0.000 0.000 -f_cyan_ilr_1 0.000 0.000 0.000 -f_cyan_ilr_2 0.000 0.000 0.000 -f_JCZ38_qlogis 0.000 0.000 0.000 -f_JSE76_qlogis 0.000 0.000 0.000 - log_k_cyan_bound_free log_k_JCZ38 log_k_J9Z38 log_k_JSE76 -cyan_free_0 0.000 0.0000 0.000 0.0000 -log_k_cyan_free 0.000 0.0000 0.000 0.0000 -log_k_cyan_free_bound 0.000 0.0000 0.000 0.0000 -log_k_cyan_bound_free 1.213 0.0000 0.000 0.0000 -log_k_JCZ38 0.000 0.7801 0.000 0.0000 -log_k_J9Z38 0.000 0.0000 1.575 0.0000 -log_k_JSE76 0.000 0.0000 0.000 0.8078 -f_cyan_ilr_1 0.000 0.0000 0.000 0.0000 -f_cyan_ilr_2 0.000 0.0000 0.000 0.0000 -f_JCZ38_qlogis 0.000 0.0000 0.000 0.0000 -f_JSE76_qlogis 0.000 0.0000 0.000 0.0000 - f_cyan_ilr_1 f_cyan_ilr_2 f_JCZ38_qlogis f_JSE76_qlogis -cyan_free_0 0.0000 0.00 0.00 0.00 -log_k_cyan_free 0.0000 0.00 0.00 0.00 -log_k_cyan_free_bound 0.0000 0.00 0.00 0.00 -log_k_cyan_bound_free 0.0000 0.00 0.00 0.00 -log_k_JCZ38 0.0000 0.00 0.00 0.00 -log_k_J9Z38 0.0000 0.00 0.00 0.00 -log_k_JSE76 0.0000 0.00 0.00 0.00 -f_cyan_ilr_1 0.6519 0.00 0.00 0.00 -f_cyan_ilr_2 0.0000 10.78 0.00 0.00 -f_JCZ38_qlogis 0.0000 0.00 13.96 0.00 -f_JSE76_qlogis 0.0000 0.00 0.00 14.69 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 2236 2228 -1098 - -Optimised parameters: - est. lower upper -cyan_free_0 100.72760 NA NA -log_k_cyan_free -3.18281 NA NA -log_k_cyan_free_bound -3.37924 NA NA -log_k_cyan_bound_free -3.77107 NA NA -log_k_JCZ38 -2.92811 NA NA -log_k_J9Z38 -5.02759 NA NA -log_k_JSE76 -3.65835 NA NA -f_cyan_ilr_1 0.67390 NA NA -f_cyan_ilr_2 1.15106 NA NA -f_JCZ38_qlogis 827.82299 NA NA -f_JSE76_qlogis 1.83064 NA NA -a.1 2.06921 1.84443 2.29399 -b.1 0.06391 0.05267 0.07515 -SD.log_k_cyan_free 0.50518 0.18962 0.82075 -SD.log_k_cyan_bound_free 0.30991 0.08170 0.53813 -SD.log_k_JCZ38 1.26661 0.46578 2.06744 -SD.log_k_J9Z38 0.88272 0.27813 1.48730 -SD.log_k_JSE76 0.53050 0.12561 0.93538 -SD.f_cyan_ilr_1 0.35547 0.12461 0.58633 -SD.f_cyan_ilr_2 0.91446 0.20131 1.62761 - -Correlation is not available - -Random effects: - est. lower upper -SD.log_k_cyan_free 0.5052 0.1896 0.8207 -SD.log_k_cyan_bound_free 0.3099 0.0817 0.5381 -SD.log_k_JCZ38 1.2666 0.4658 2.0674 -SD.log_k_J9Z38 0.8827 0.2781 1.4873 -SD.log_k_JSE76 0.5305 0.1256 0.9354 -SD.f_cyan_ilr_1 0.3555 0.1246 0.5863 -SD.f_cyan_ilr_2 0.9145 0.2013 1.6276 - -Variance model: - est. lower upper -a.1 2.06921 1.84443 2.29399 -b.1 0.06391 0.05267 0.07515 - -Backtransformed parameters: - est. lower upper -cyan_free_0 1.007e+02 NA NA -k_cyan_free 4.147e-02 NA NA -k_cyan_free_bound 3.407e-02 NA NA -k_cyan_bound_free 2.303e-02 NA NA -k_JCZ38 5.350e-02 NA NA -k_J9Z38 6.555e-03 NA NA -k_JSE76 2.578e-02 NA NA -f_cyan_free_to_JCZ38 6.505e-01 NA NA -f_cyan_free_to_J9Z38 2.508e-01 NA NA -f_JCZ38_to_JSE76 1.000e+00 NA NA -f_JSE76_to_JCZ38 8.618e-01 NA NA - -Estimated Eigenvalues of SFORB model(s): -cyan_b1 cyan_b2 cyan_g -0.08768 0.01089 0.39821 - -Resulting formation fractions: - ff -cyan_free_JCZ38 0.65053 -cyan_free_J9Z38 0.25082 -cyan_free_sink 0.09864 -cyan_free 1.00000 -JCZ38_JSE76 1.00000 -JCZ38_sink 0.00000 -JSE76_JCZ38 0.86184 -JSE76_sink 0.13816 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_cyan_b1 DT50_cyan_b2 -cyan 25.32 164.79 49.61 7.906 63.64 -JCZ38 12.96 43.04 NA NA NA -J9Z38 105.75 351.29 NA NA NA -JSE76 26.89 89.33 NA NA NA - -</code></pre> -<p></p> -</div> -</div> -<div class="section level3"> -<h3 id="session-info">Session info<a class="anchor" aria-label="anchor" href="#session-info"></a> -</h3> -<pre><code>R version 4.2.3 (2023-03-15) -Platform: x86_64-pc-linux-gnu (64-bit) -Running under: Debian GNU/Linux 12 (bookworm) - -Matrix products: default -BLAS: /usr/lib/x86_64-linux-gnu/openblas-serial/libblas.so.3 -LAPACK: /usr/lib/x86_64-linux-gnu/openblas-serial/libopenblas-r0.3.21.so - -locale: - [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C - [3] LC_TIME=de_DE.UTF-8 LC_COLLATE=de_DE.UTF-8 - [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8 - [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C - [9] LC_ADDRESS=C LC_TELEPHONE=C -[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C - -attached base packages: -[1] parallel stats graphics grDevices utils datasets methods -[8] base - -other attached packages: -[1] saemix_3.2 npde_3.3 knitr_1.42 mkin_1.2.4 - -loaded via a namespace (and not attached): - [1] deSolve_1.35 zoo_1.8-12 tidyselect_1.2.0 xfun_0.38 - [5] bslib_0.4.2 purrr_1.0.1 lattice_0.21-8 colorspace_2.1-0 - [9] vctrs_0.6.1 generics_0.1.3 htmltools_0.5.5 yaml_2.3.7 -[13] utf8_1.2.3 rlang_1.1.0 pkgbuild_1.4.0 pkgdown_2.0.7 -[17] jquerylib_0.1.4 pillar_1.9.0 glue_1.6.2 DBI_1.1.3 -[21] readxl_1.4.2 lifecycle_1.0.3 stringr_1.5.0 munsell_0.5.0 -[25] gtable_0.3.3 cellranger_1.1.0 ragg_1.2.5 codetools_0.2-19 -[29] memoise_2.0.1 evaluate_0.20 inline_0.3.19 callr_3.7.3 -[33] fastmap_1.1.1 ps_1.7.4 lmtest_0.9-40 fansi_1.0.4 -[37] highr_0.10 scales_1.2.1 cachem_1.0.7 desc_1.4.2 -[41] jsonlite_1.8.4 systemfonts_1.0.4 fs_1.6.1 textshaping_0.3.6 -[45] gridExtra_2.3 ggplot2_3.4.2 digest_0.6.31 stringi_1.7.12 -[49] processx_3.8.0 dplyr_1.1.1 grid_4.2.3 rprojroot_2.0.3 -[53] cli_3.6.1 tools_4.2.3 magrittr_2.0.3 sass_0.4.5 -[57] tibble_3.2.1 crayon_1.5.2 pkgconfig_2.0.3 prettyunits_1.1.1 -[61] rmarkdown_2.21 R6_2.5.1 mclust_6.0.0 nlme_3.1-162 -[65] compiler_4.2.3 </code></pre> -</div> -<div class="section level3"> -<h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a> -</h3> -<pre><code>CPU model: AMD Ryzen 9 7950X 16-Core Processor</code></pre> -<pre><code>MemTotal: 64936316 kB</code></pre> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git 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NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Testing hierarchical parent degradation kinetics -with residue data on dimethenamid and dimethenamid-P</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change on 5 January -2023, last compiled on 16 April 2023</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_dmta_parent.rmd" class="external-link"><code>vignettes/prebuilt/2022_dmta_parent.rmd</code></a></small> - <div class="hidden name"><code>2022_dmta_parent.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>The purpose of this document is to demonstrate how nonlinear -hierarchical models (NLHM) based on the parent degradation models SFO, -FOMC, DFOP and HS can be fitted with the mkin package.</p> -<p>It was assembled in the course of work package 1.1 of Project Number -173340 (Application of nonlinear hierarchical models to the kinetic -evaluation of chemical degradation data) of the German Environment -Agency carried out in 2022 and 2023.</p> -<p>The mkin package is used in version 1.2.3. It contains the test data -and the functions used in the evaluations. The <code>saemix</code> -package is used as a backend for fitting the NLHM, but is also loaded to -make the convergence plot function available.</p> -<p>This document is processed with the <code>knitr</code> package, which -also provides the <code>kable</code> function that is used to improve -the display of tabular data in R markdown documents. For parallel -processing, the <code>parallel</code> package is used.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://yihui.org/knitr/" class="external-link">knitr</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">parallel</span><span class="op">)</span></span> -<span><span class="va">n_cores</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span> -<span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makeForkCluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="data">Data<a class="anchor" aria-label="anchor" href="#data"></a> -</h2> -<p>The test data are available in the mkin package as an object of class -<code>mkindsg</code> (mkin dataset group) under the identifier -<code>dimethenamid_2018</code>. The following preprocessing steps are -still necessary:</p> -<ul> -<li>The data available for the enantiomer dimethenamid-P (DMTAP) are -renamed to have the same substance name as the data for the racemic -mixture dimethenamid (DMTA). The reason for this is that no difference -between their degradation behaviour was identified in the EU risk -assessment.</li> -<li>The data for transformation products and unnecessary columns are -discarded</li> -<li>The observation times of each dataset are multiplied with the -corresponding normalisation factor also available in the dataset, in -order to make it possible to describe all datasets with a single set of -parameters that are independent of temperature</li> -<li>Finally, datasets observed in the same soil (<code>Elliot 1</code> -and <code>Elliot 2</code>) are combined, resulting in dimethenamid -(DMTA) data from six soils.</li> -</ul> -<p>The following commented R code performs this preprocessing.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="co"># Apply a function to each of the seven datasets in the mkindsg object to create a list</span></span> -<span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span> <span class="co"># Get a dataset</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span> <span class="co"># Rename DMTAP to DMTA</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">ds_i</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"DMTA"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">)</span> <span class="co"># Select data</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span> <span class="co"># Normalise time</span></span> -<span> <span class="va">ds_i</span> <span class="co"># Return the dataset</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Use dataset titles as names for the list elements</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Combine data for Elliot soil to obtain a named list with six elements</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> <span class="co">#</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -<p>The following tables show the 6 datasets.</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">for</span> <span class="op">(</span><span class="va">ds_name</span> <span class="kw">in</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mkin_long_to_wide.html">mkin_long_to_wide</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="va">ds_name</span><span class="op">]</span><span class="op">]</span><span class="op">)</span>,</span> -<span> caption <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="va">ds_name</span><span class="op">)</span>,</span> -<span> label <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"tab:"</span>, <span class="va">ds_name</span><span class="op">)</span>, booktabs <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span><span class="st">"\n\\clearpage\n"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<table class="table"> -<caption>Dataset Calke</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0</td> -<td align="right">95.8</td> -</tr> -<tr class="even"> -<td align="right">0</td> -<td align="right">98.7</td> -</tr> -<tr class="odd"> -<td align="right">14</td> -<td align="right">60.5</td> -</tr> -<tr class="even"> -<td align="right">30</td> -<td align="right">39.1</td> -</tr> -<tr class="odd"> -<td align="right">59</td> -<td align="right">15.2</td> -</tr> -<tr class="even"> -<td align="right">120</td> -<td align="right">4.8</td> -</tr> -<tr class="odd"> -<td align="right">120</td> -<td align="right">4.6</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Borstel</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">100.5</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">99.6</td> -</tr> -<tr class="odd"> -<td align="right">1.941295</td> -<td align="right">91.9</td> -</tr> -<tr class="even"> -<td align="right">1.941295</td> -<td align="right">91.3</td> -</tr> -<tr class="odd"> -<td align="right">6.794534</td> -<td align="right">81.8</td> -</tr> -<tr class="even"> -<td align="right">6.794534</td> -<td align="right">82.1</td> -</tr> -<tr class="odd"> -<td align="right">13.589067</td> -<td align="right">69.1</td> -</tr> -<tr class="even"> -<td align="right">13.589067</td> -<td align="right">68.0</td> -</tr> -<tr class="odd"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -</tr> -<tr class="even"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -</tr> -<tr class="odd"> -<td align="right">56.297565</td> -<td align="right">27.6</td> -</tr> -<tr class="even"> -<td align="right">56.297565</td> -<td align="right">26.8</td> -</tr> -<tr class="odd"> -<td align="right">86.387643</td> -<td align="right">15.7</td> -</tr> -<tr class="even"> -<td align="right">86.387643</td> -<td align="right">15.3</td> -</tr> -<tr class="odd"> -<td align="right">115.507073</td> -<td align="right">7.9</td> -</tr> -<tr class="even"> -<td align="right">115.507073</td> -<td align="right">8.1</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Flaach</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">96.5</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">96.8</td> -</tr> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">97.0</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">82.9</td> -</tr> -<tr class="odd"> -<td align="right">0.6233856</td> -<td align="right">86.7</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">87.4</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">72.8</td> -</tr> -<tr class="even"> -<td align="right">1.8701567</td> -<td align="right">69.9</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">71.9</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">51.4</td> -</tr> -<tr class="odd"> -<td align="right">4.3636989</td> -<td align="right">52.9</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">48.6</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">28.5</td> -</tr> -<tr class="even"> -<td align="right">8.7273979</td> -<td align="right">27.3</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">27.5</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.8</td> -</tr> -<tr class="odd"> -<td align="right">13.0910968</td> -<td align="right">13.4</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.4</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">7.7</td> -</tr> -<tr class="even"> -<td align="right">17.4547957</td> -<td align="right">7.3</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">8.1</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">2.0</td> -</tr> -<tr class="odd"> -<td align="right">26.1821936</td> -<td align="right">1.5</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">1.9</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.3</td> -</tr> -<tr class="even"> -<td align="right">34.9095915</td> -<td align="right">1.0</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.1</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.9</td> -</tr> -<tr class="odd"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.6</td> -</tr> -<tr class="even"> -<td align="right">52.3643872</td> -<td align="right">0.4</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.5</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.4</td> -</tr> -<tr class="odd"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.2</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">98.09</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">98.77</td> -</tr> -<tr class="odd"> -<td align="right">0.7678922</td> -<td align="right">93.52</td> -</tr> -<tr class="even"> -<td align="right">0.7678922</td> -<td align="right">92.03</td> -</tr> -<tr class="odd"> -<td align="right">2.3036765</td> -<td align="right">88.39</td> -</tr> -<tr class="even"> -<td align="right">2.3036765</td> -<td align="right">87.18</td> -</tr> -<tr class="odd"> -<td align="right">5.3752452</td> -<td align="right">69.38</td> -</tr> -<tr class="even"> -<td align="right">5.3752452</td> -<td align="right">71.06</td> -</tr> -<tr class="odd"> -<td align="right">10.7504904</td> -<td align="right">45.21</td> -</tr> -<tr class="even"> -<td align="right">10.7504904</td> -<td align="right">46.81</td> -</tr> -<tr class="odd"> -<td align="right">16.1257355</td> -<td align="right">30.54</td> -</tr> -<tr class="even"> -<td align="right">16.1257355</td> -<td align="right">30.07</td> -</tr> -<tr class="odd"> -<td align="right">21.5009807</td> -<td align="right">21.60</td> -</tr> -<tr class="even"> -<td align="right">21.5009807</td> -<td align="right">20.41</td> -</tr> -<tr class="odd"> -<td align="right">32.2514711</td> -<td align="right">9.10</td> -</tr> -<tr class="even"> -<td align="right">32.2514711</td> -<td align="right">9.70</td> -</tr> -<tr class="odd"> -<td align="right">43.0019614</td> -<td align="right">6.58</td> -</tr> -<tr class="even"> -<td align="right">43.0019614</td> -<td align="right">6.31</td> -</tr> -<tr class="odd"> -<td align="right">53.7524518</td> -<td align="right">3.47</td> -</tr> -<tr class="even"> -<td align="right">53.7524518</td> -<td align="right">3.52</td> -</tr> -<tr class="odd"> -<td align="right">64.5029421</td> -<td align="right">3.40</td> -</tr> -<tr class="even"> -<td align="right">64.5029421</td> -<td align="right">3.67</td> -</tr> -<tr class="odd"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -</tr> -<tr class="even"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.3</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">99.33</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">97.44</td> -</tr> -<tr class="odd"> -<td align="right">0.6733938</td> -<td align="right">93.73</td> -</tr> -<tr class="even"> -<td align="right">0.6733938</td> -<td align="right">93.77</td> -</tr> -<tr class="odd"> -<td align="right">2.0201814</td> -<td align="right">87.84</td> -</tr> -<tr class="even"> -<td align="right">2.0201814</td> -<td align="right">89.82</td> -</tr> -<tr class="odd"> -<td align="right">4.7137565</td> -<td align="right">71.61</td> -</tr> -<tr class="even"> -<td align="right">4.7137565</td> -<td align="right">71.42</td> -</tr> -<tr class="odd"> -<td align="right">9.4275131</td> -<td align="right">45.60</td> -</tr> -<tr class="even"> -<td align="right">9.4275131</td> -<td align="right">45.42</td> -</tr> -<tr class="odd"> -<td align="right">14.1412696</td> -<td align="right">31.12</td> -</tr> -<tr class="even"> -<td align="right">14.1412696</td> -<td align="right">31.68</td> -</tr> -<tr class="odd"> -<td align="right">18.8550262</td> -<td align="right">23.20</td> -</tr> -<tr class="even"> -<td align="right">18.8550262</td> -<td align="right">24.13</td> -</tr> -<tr class="odd"> -<td align="right">28.2825393</td> -<td align="right">9.43</td> -</tr> -<tr class="even"> -<td align="right">28.2825393</td> -<td align="right">9.82</td> -</tr> -<tr class="odd"> -<td align="right">37.7100523</td> -<td align="right">7.08</td> -</tr> -<tr class="even"> -<td align="right">37.7100523</td> -<td align="right">8.64</td> -</tr> -<tr class="odd"> -<td align="right">47.1375654</td> -<td align="right">4.41</td> -</tr> -<tr class="even"> -<td align="right">47.1375654</td> -<td align="right">4.78</td> -</tr> -<tr class="odd"> -<td align="right">56.5650785</td> -<td align="right">4.92</td> -</tr> -<tr class="even"> -<td align="right">56.5650785</td> -<td align="right">5.08</td> -</tr> -<tr class="odd"> -<td align="right">80.1338612</td> -<td align="right">2.13</td> -</tr> -<tr class="even"> -<td align="right">80.1338612</td> -<td align="right">2.23</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Elliot</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">97.5</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">100.7</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">86.4</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">88.5</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">69.8</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">77.1</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">59.0</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">54.2</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">31.3</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.5</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">19.6</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">13.3</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">15.8</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">6.7</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">8.8</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">6.0</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">3.3</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">2.8</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">1.4</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.8</td> -</tr> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">93.4</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">103.2</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">89.2</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">86.6</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">78.2</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">78.1</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">55.6</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">53.0</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">33.7</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.2</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">19.9</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">18.2</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">12.7</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">7.8</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">9.0</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">11.4</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">9.0</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">3.9</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">2.6</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">3.4</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">2.0</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.7</td> -</tr> -</tbody> -</table> -</div> -<div class="section level2"> -<h2 id="separate-evaluations">Separate evaluations<a class="anchor" aria-label="anchor" href="#separate-evaluations"></a> -</h2> -<p>In order to obtain suitable starting parameters for the NLHM fits, -separate fits of the four models to the data for each soil are generated -using the <code>mmkin</code> function from the <code>mkin</code> -package. In a first step, constant variance is assumed. Convergence is -checked with the <code>status</code> function.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">deg_mods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span></span> -<span><span class="va">f_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span></span> -<span> <span class="va">deg_mods</span>,</span> -<span> <span class="va">dmta_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_const</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>In the table above, OK indicates convergence, and C indicates failure -to converge. All separate fits with constant variance converged, with -the sole exception of the HS fit to the BBA 2.2 data. To prepare for -fitting NLHM using the two-component error model, the separate fits are -updated assuming two-component error.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_sep_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>Using the two-component error model, the one fit that did not -converge with constant variance did converge, but other non-SFO fits -failed to converge.</p> -</div> -<div class="section level2"> -<h2 id="hierarchichal-model-fits">Hierarchichal model fits<a class="anchor" aria-label="anchor" href="#hierarchichal-model-fits"></a> -</h2> -<p>The following code fits eight versions of hierarchical models to the -data, using SFO, FOMC, DFOP and HS for the parent compound, and using -either constant variance or two-component error for the error model. The -default parameter distribution model in mkin allows for variation of all -degradation parameters across the assumed population of soils. In other -words, each degradation parameter is associated with a random effect as -a first step. The <code>mhmkin</code> function makes it possible to fit -all eight versions in parallel (given a sufficient number of computing -cores being available) to save execution time.</p> -<p>Convergence plots and summaries for these fits are shown in the -appendix.</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_sep_const</span>, <span class="va">f_sep_tc</span><span class="op">)</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span></code></pre></div> -<p>The output of the <code>status</code> function shows that all fits -terminated successfully.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>The AIC and BIC values show that the biphasic models DFOP and HS give -the best fits.</p> -<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO const</td> -<td align="right">5</td> -<td align="right">796.3</td> -<td align="right">795.3</td> -<td align="right">-393.2</td> -</tr> -<tr class="even"> -<td align="left">SFO tc</td> -<td align="right">6</td> -<td align="right">798.3</td> -<td align="right">797.1</td> -<td align="right">-393.2</td> -</tr> -<tr class="odd"> -<td align="left">FOMC const</td> -<td align="right">7</td> -<td align="right">734.2</td> -<td align="right">732.7</td> -<td align="right">-360.1</td> -</tr> -<tr class="even"> -<td align="left">FOMC tc</td> -<td align="right">8</td> -<td align="right">720.4</td> -<td align="right">718.8</td> -<td align="right">-352.2</td> -</tr> -<tr class="odd"> -<td align="left">DFOP const</td> -<td align="right">9</td> -<td align="right">711.8</td> -<td align="right">710.0</td> -<td align="right">-346.9</td> -</tr> -<tr class="even"> -<td align="left">HS const</td> -<td align="right">9</td> -<td align="right">714.0</td> -<td align="right">712.1</td> -<td align="right">-348.0</td> -</tr> -<tr class="odd"> -<td align="left">DFOP tc</td> -<td align="right">10</td> -<td align="right">665.5</td> -<td align="right">663.4</td> -<td align="right">-322.8</td> -</tr> -<tr class="even"> -<td align="left">HS tc</td> -<td align="right">10</td> -<td align="right">667.1</td> -<td align="right">665.0</td> -<td align="right">-323.6</td> -</tr> -</tbody> -</table> -<p>The DFOP model is preferred here, as it has a better mechanistic -basis for batch experiments with constant incubation conditions. Also, -it shows the lowest AIC and BIC values in the first set of fits when -combined with the two-component error model. Therefore, the DFOP model -was selected for further refinements of the fits with the aim to make -the model fully identifiable.</p> -<div class="section level3"> -<h3 id="parameter-identifiability-based-on-the-fisher-information-matrix">Parameter identifiability based on the Fisher Information -Matrix<a class="anchor" aria-label="anchor" href="#parameter-identifiability-based-on-the-fisher-information-matrix"></a> -</h3> -<p>Using the <code>illparms</code> function, ill-defined statistical -model parameters such as standard deviations of the degradation -parameters in the population and error model parameters can be -found.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left"></td> -<td align="left">b.1</td> -</tr> -<tr class="even"> -<td align="left">FOMC</td> -<td align="left"></td> -<td align="left">sd(DMTA_0)</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">sd(k2)</td> -<td align="left">sd(k2)</td> -</tr> -<tr class="even"> -<td align="left">HS</td> -<td align="left"></td> -<td align="left">sd(tb)</td> -</tr> -</tbody> -</table> -<p>According to the <code>illparms</code> function, the fitted standard -deviation of the second kinetic rate constant <code>k2</code> is -ill-defined in both DFOP fits. This suggests that different values would -be obtained for this standard deviation when using different starting -values.</p> -<p>The thus identified overparameterisation is addressed by removing the -random effect for <code>k2</code> from the parameter model.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_no_ranef_k2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"k2"</span><span class="op">)</span></span></code></pre></div> -<p>For the resulting fit, it is checked whether there are still -ill-defined parameters,</p> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<p>which is not the case. Below, the refined model is compared with the -previous best model. The model without random effect for <code>k2</code> -is a reduced version of the previous model. Therefore, the models are -nested and can be compared using the likelihood ratio test. This is -achieved with the argument <code>test = TRUE</code> to the -<code>anova</code> function.</p> -<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>, <span class="va">f_saem_dfop_tc_no_ranef_k2</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="op">|></span></span> -<span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>format.args <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">4</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<colgroup> -<col width="37%"> -<col width="6%"> -<col width="8%"> -<col width="8%"> -<col width="9%"> -<col width="9%"> -<col width="4%"> -<col width="15%"> -</colgroup> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -<th align="right">Chisq</th> -<th align="right">Df</th> -<th align="right">Pr(>Chisq)</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">f_saem_dfop_tc_no_ranef_k2</td> -<td align="right">9</td> -<td align="right">663.8</td> -<td align="right">661.9</td> -<td align="right">-322.9</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="left">f_saem[[“DFOP”, “tc”]]</td> -<td align="right">10</td> -<td align="right">665.5</td> -<td align="right">663.4</td> -<td align="right">-322.8</td> -<td align="right">0.2809</td> -<td align="right">1</td> -<td align="right">0.5961</td> -</tr> -</tbody> -</table> -<p>The AIC and BIC criteria are lower after removal of the ill-defined -random effect for <code>k2</code>. The p value of the likelihood ratio -test is much greater than 0.05, indicating that the model with the -higher likelihood (here the model with random effects for all -degradation parameters <code>f_saem[["DFOP", "tc"]]</code>) does not fit -significantly better than the model with the lower likelihood (the -reduced model <code>f_saem_dfop_tc_no_ranef_k2</code>).</p> -<p>Therefore, AIC, BIC and likelihood ratio test suggest the use of the -reduced model.</p> -<p>The convergence of the fit is checked visually.</p> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-dfop-tc-no-ranef-k2-1.png" alt="Convergence plot for the NLHM DFOP fit with two-component error and without a random effect on 'k2'" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with two-component error and -without a random effect on ‘k2’ -</p> -</div> -<p>All parameters appear to have converged to a satisfactory degree. The -final fit is plotted using the plot method from the mkin package.</p> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/plot-saem-dfop-tc-no-ranef-k2-1.png" alt="Plot of the final NLHM DFOP fit" width="864"><p class="caption"> -Plot of the final NLHM DFOP fit -</p> -</div> -<p>Finally, a summary report of the fit is produced.</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span><span class="op">)</span></span></code></pre></div> -<pre><code>saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:51 2023 -Date of summary: Sat Jan 28 11:22:52 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 3.74 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.759266 0.087034 0.009933 0.930827 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.76 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 663.8 661.9 -322.9 - -Optimised parameters: - est. lower upper -DMTA_0 98.228939 96.285869 100.17201 -k1 0.064063 0.033477 0.09465 -k2 0.008297 0.005824 0.01077 -g 0.953821 0.914328 0.99331 -a.1 1.068479 0.869538 1.26742 -b.1 0.029424 0.022406 0.03644 -SD.DMTA_0 2.030437 0.404824 3.65605 -SD.k1 0.594692 0.256660 0.93272 -SD.g 1.006754 0.361327 1.65218 - -Correlation: - DMTA_0 k1 k2 -k1 0.0218 -k2 0.0556 0.0355 -g -0.0516 -0.0284 -0.2800 - -Random effects: - est. lower upper -SD.DMTA_0 2.0304 0.4048 3.6560 -SD.k1 0.5947 0.2567 0.9327 -SD.g 1.0068 0.3613 1.6522 - -Variance model: - est. lower upper -a.1 1.06848 0.86954 1.26742 -b.1 0.02942 0.02241 0.03644 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.45 41.4 12.46 10.82 83.54</code></pre> -</div> -<div class="section level3"> -<h3 id="alternative-check-of-parameter-identifiability">Alternative check of parameter identifiability<a class="anchor" aria-label="anchor" href="#alternative-check-of-parameter-identifiability"></a> -</h3> -<p>The parameter check used in the <code>illparms</code> function is -based on a quadratic approximation of the likelihood surface near its -optimum, which is calculated using the Fisher Information Matrix (FIM). -An alternative way to check parameter identifiability <span class="citation">(Duchesne et al. 2021)</span> based on a multistart -approach has recently been implemented in mkin.</p> -<p>The graph below shows boxplots of the parameters obtained in 50 runs -of the saem algorithm with different parameter combinations, sampled -from the range of the parameters obtained for the individual datasets -fitted separately using nonlinear regression.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_multi</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">[[</span><span class="st">"DFOP"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>, n <span class="op">=</span> <span class="fl">50</span>, cores <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_multi</span>, lpos <span class="op">=</span> <span class="st">"bottomright"</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.3</span>, <span class="fl">10</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/multistart-full-par-1.png" alt="Scaled parameters from the multistart runs, full model" width="960"><p class="caption"> -Scaled parameters from the multistart runs, full model -</p> -</div> -<p>The graph clearly confirms the lack of identifiability of the -variance of <code>k2</code> in the full model. The overparameterisation -of the model also indicates a lack of identifiability of the variance of -parameter <code>g</code>.</p> -<p>The parameter boxplots of the multistart runs with the reduced model -shown below indicate that all runs give similar results, regardless of -the starting parameters.</p> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2</span>,</span> -<span> n <span class="op">=</span> <span class="fl">50</span>, cores <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomright"</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/multistart-reduced-par-1.png" alt="Scaled parameters from the multistart runs, reduced model" width="960"><p class="caption"> -Scaled parameters from the multistart runs, reduced model -</p> -</div> -<p>When only the parameters of the top 25% of the fits are shown (based -on a feature introduced in mkin 1.2.2 currently under development), the -scatter is even less as shown below.</p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">6.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_dfop_tc_no_ranef_k2_multi</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span>, llquant <span class="op">=</span> <span class="fl">0.25</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomright"</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/multistart-reduced-par-llquant-1.png" alt="Scaled parameters from the multistart runs, reduced model, fits with the top 25\% likelihood values" width="960"><p class="caption"> -Scaled parameters from the multistart runs, reduced model, fits with the -top 25% likelihood values -</p> -</div> -</div> -</div> -<div class="section level2"> -<h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#conclusions"></a> -</h2> -<p>Fitting the four parent degradation models SFO, FOMC, DFOP and HS as -part of hierarchical model fits with two different error models and -normal distributions of the transformed degradation parameters works -without technical problems. The biphasic models DFOP and HS gave the -best fit to the data, but the default parameter distribution model was -not fully identifiable. Removing the random effect for the second -kinetic rate constant of the DFOP model resulted in a reduced model that -was fully identifiable and showed the lowest values for the model -selection criteria AIC and BIC. The reliability of the identification of -all model parameters was confirmed using multiple starting values.</p> -</div> -<div class="section level2"> -<h2 id="acknowledgements">Acknowledgements<a class="anchor" aria-label="anchor" href="#acknowledgements"></a> -</h2> -<p>The helpful comments by Janina Wöltjen of the German Environment -Agency are gratefully acknowledged.</p> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-duchesne_2021" class="csl-entry"> -Duchesne, Ronan, Anissa Guillemin, Olivier Gandrillon, and Fabien -Crauste. 2021. <span>“Practical Identifiability in the Frame of -Nonlinear Mixed Effects Models: The Example of the in Vitro -Erythropoiesis.”</span> <em>BMC Bioinformatics</em> 22 (478). <a href="https://doi.org/10.1186/s12859-021-04373-4" class="external-link">https://doi.org/10.1186/s12859-021-04373-4</a>. -</div> -</div> -</div> -<div class="section level2"> -<h2 id="appendix">Appendix<a class="anchor" aria-label="anchor" href="#appendix"></a> -</h2> -<div class="section level3"> -<h3 id="hierarchical-model-fit-listings">Hierarchical model fit listings<a class="anchor" aria-label="anchor" href="#hierarchical-model-fit-listings"></a> -</h3> -<caption> -Hierarchical mkin fit of the SFO model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:44 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - k_DMTA * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 0.982 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k_DMTA -97.2953 0.0566 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k_DMTA -DMTA_0 97.3 0 -k_DMTA 0.0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 796.3 795.3 -393.2 - -Optimised parameters: - est. lower upper -DMTA_0 97.28130 95.71113 98.8515 -k_DMTA 0.05665 0.02909 0.0842 -a.1 2.66442 2.35579 2.9731 -SD.DMTA_0 1.54776 0.15447 2.9411 -SD.k_DMTA 0.60690 0.26248 0.9513 - -Correlation: - DMTA_0 -k_DMTA 0.0168 - -Random effects: - est. lower upper -SD.DMTA_0 1.5478 0.1545 2.9411 -SD.k_DMTA 0.6069 0.2625 0.9513 - -Variance model: - est. lower upper -a.1 2.664 2.356 2.973 - -Estimated disappearance times: - DT50 DT90 -DMTA 12.24 40.65 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the SFO model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:46 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - k_DMTA * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.39 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k_DMTA -96.99175 0.05603 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k_DMTA -DMTA_0 96.99 0 -k_DMTA 0.00 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 798.3 797.1 -393.2 - -Optimised parameters: - est. lower upper -DMTA_0 97.271822 95.703157 98.84049 -k_DMTA 0.056638 0.029110 0.08417 -a.1 2.660081 2.230398 3.08976 -b.1 0.001665 -0.006911 0.01024 -SD.DMTA_0 1.545520 0.145035 2.94601 -SD.k_DMTA 0.606422 0.262274 0.95057 - -Correlation: - DMTA_0 -k_DMTA 0.0169 - -Random effects: - est. lower upper -SD.DMTA_0 1.5455 0.1450 2.9460 -SD.k_DMTA 0.6064 0.2623 0.9506 - -Variance model: - est. lower upper -a.1 2.660081 2.230398 3.08976 -b.1 0.001665 -0.006911 0.01024 - -Estimated disappearance times: - DT50 DT90 -DMTA 12.24 40.65 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the FOMC model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:45 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - (alpha/beta) * 1/((time/beta) + 1) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 1.552 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 alpha beta - 98.292 9.909 156.341 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 alpha beta -DMTA_0 98.29 0 0 -alpha 0.00 1 0 -beta 0.00 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 734.2 732.7 -360.1 - -Optimised parameters: - est. lower upper -DMTA_0 98.3435 96.9033 99.784 -alpha 7.2007 2.5889 11.812 -beta 112.8746 34.8816 190.868 -a.1 2.0459 1.8054 2.286 -SD.DMTA_0 1.4795 0.2717 2.687 -SD.alpha 0.6396 0.1509 1.128 -SD.beta 0.6874 0.1587 1.216 - -Correlation: - DMTA_0 alpha -alpha -0.1125 -beta -0.1227 0.3632 - -Random effects: - est. lower upper -SD.DMTA_0 1.4795 0.2717 2.687 -SD.alpha 0.6396 0.1509 1.128 -SD.beta 0.6874 0.1587 1.216 - -Variance model: - est. lower upper -a.1 2.046 1.805 2.286 - -Estimated disappearance times: - DT50 DT90 DT50back -DMTA 11.41 42.53 12.8 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the FOMC model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:46 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - (alpha/beta) * 1/((time/beta) + 1) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.764 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: -DMTA_0 alpha beta -98.772 4.663 92.597 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 alpha beta -DMTA_0 98.77 0 0 -alpha 0.00 1 0 -beta 0.00 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 720.4 718.8 -352.2 - -Optimised parameters: - est. lower upper -DMTA_0 98.99136 97.26011 100.72261 -alpha 5.86312 2.57485 9.15138 -beta 88.55571 29.20889 147.90254 -a.1 1.51063 1.24384 1.77741 -b.1 0.02824 0.02040 0.03609 -SD.DMTA_0 1.57436 -0.04867 3.19739 -SD.alpha 0.59871 0.17132 1.02611 -SD.beta 0.72994 0.22849 1.23139 - -Correlation: - DMTA_0 alpha -alpha -0.1363 -beta -0.1414 0.2542 - -Random effects: - est. lower upper -SD.DMTA_0 1.5744 -0.04867 3.197 -SD.alpha 0.5987 0.17132 1.026 -SD.beta 0.7299 0.22849 1.231 - -Variance model: - est. lower upper -a.1 1.51063 1.2438 1.77741 -b.1 0.02824 0.0204 0.03609 - -Estimated disappearance times: - DT50 DT90 DT50back -DMTA 11.11 42.6 12.82 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the DFOP model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:45 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 1.649 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.64383 0.09211 0.02999 0.76814 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.64 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 711.8 710 -346.9 - -Optimised parameters: - est. lower upper -DMTA_0 98.092481 96.573898 99.61106 -k1 0.062499 0.030336 0.09466 -k2 0.009065 -0.005133 0.02326 -g 0.948967 0.862079 1.03586 -a.1 1.821671 1.604774 2.03857 -SD.DMTA_0 1.677785 0.472066 2.88350 -SD.k1 0.634962 0.270788 0.99914 -SD.k2 1.033498 -0.205994 2.27299 -SD.g 1.710046 0.428642 2.99145 - -Correlation: - DMTA_0 k1 k2 -k1 0.0246 -k2 0.0491 0.0953 -g -0.0552 -0.0889 -0.4795 - -Random effects: - est. lower upper -SD.DMTA_0 1.678 0.4721 2.8835 -SD.k1 0.635 0.2708 0.9991 -SD.k2 1.033 -0.2060 2.2730 -SD.g 1.710 0.4286 2.9914 - -Variance model: - est. lower upper -a.1 1.822 1.605 2.039 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.79 42.8 12.88 11.09 76.46 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the DFOP model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:46 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 3.288 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 g -98.759266 0.087034 0.009933 0.930827 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 g -DMTA_0 98.76 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -g 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 665.5 663.4 -322.8 - -Optimised parameters: - est. lower upper -DMTA_0 98.377019 96.447952 100.30609 -k1 0.064843 0.034607 0.09508 -k2 0.008895 0.006368 0.01142 -g 0.949696 0.903815 0.99558 -a.1 1.065241 0.865754 1.26473 -b.1 0.029340 0.022336 0.03634 -SD.DMTA_0 2.007754 0.387982 3.62753 -SD.k1 0.580473 0.250286 0.91066 -SD.k2 0.006105 -4.920337 4.93255 -SD.g 1.097149 0.412779 1.78152 - -Correlation: - DMTA_0 k1 k2 -k1 0.0235 -k2 0.0595 0.0424 -g -0.0470 -0.0278 -0.2731 - -Random effects: - est. lower upper -SD.DMTA_0 2.007754 0.3880 3.6275 -SD.k1 0.580473 0.2503 0.9107 -SD.k2 0.006105 -4.9203 4.9325 -SD.g 1.097149 0.4128 1.7815 - -Variance model: - est. lower upper -a.1 1.06524 0.86575 1.26473 -b.1 0.02934 0.02234 0.03634 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.36 41.32 12.44 10.69 77.92 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the HS model with error model const -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:45 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - ifelse(time <= tb, k1, k2) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 2.006 s -Using 300, 100 iterations and 9 chains - -Variance model: Constant variance - -Starting values for degradation parameters: - DMTA_0 k1 k2 tb -97.82176 0.06931 0.02997 11.13945 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 tb -DMTA_0 97.82 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -tb 0.00 0 0 1 - -Starting values for error model parameters: -a.1 - 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 714 712.1 -348 - -Optimised parameters: - est. lower upper -DMTA_0 98.16102 96.47747 99.84456 -k1 0.07876 0.05261 0.10491 -k2 0.02227 0.01706 0.02747 -tb 13.99089 -7.40049 35.38228 -a.1 1.82305 1.60700 2.03910 -SD.DMTA_0 1.88413 0.56204 3.20622 -SD.k1 0.34292 0.10482 0.58102 -SD.k2 0.19851 0.01718 0.37985 -SD.tb 1.68168 0.58064 2.78272 - -Correlation: - DMTA_0 k1 k2 -k1 0.0142 -k2 0.0001 -0.0025 -tb 0.0165 -0.1256 -0.0301 - -Random effects: - est. lower upper -SD.DMTA_0 1.8841 0.56204 3.2062 -SD.k1 0.3429 0.10482 0.5810 -SD.k2 0.1985 0.01718 0.3798 -SD.tb 1.6817 0.58064 2.7827 - -Variance model: - est. lower upper -a.1 1.823 1.607 2.039 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 8.801 67.91 20.44 8.801 31.13 - -</code></pre> -<p></p> -<caption> -Hierarchical mkin fit of the HS model with error model tc -</caption> -<pre><code> -saemix version used for fitting: 3.2 -mkin version used for pre-fitting: 1.2.2 -R version used for fitting: 4.2.2 -Date of fit: Sat Jan 28 11:22:46 2023 -Date of summary: Sat Jan 28 11:23:57 2023 - -Equations: -d_DMTA/dt = - ifelse(time <= tb, k1, k2) * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Model predictions using solution type analytical - -Fitted in 3.267 s -Using 300, 100 iterations and 9 chains - -Variance model: Two-component variance function - -Starting values for degradation parameters: - DMTA_0 k1 k2 tb -98.45190 0.07525 0.02576 19.19375 - -Fixed degradation parameter values: -None - -Starting values for random effects (square root of initial entries in omega): - DMTA_0 k1 k2 tb -DMTA_0 98.45 0 0 0 -k1 0.00 1 0 0 -k2 0.00 0 1 0 -tb 0.00 0 0 1 - -Starting values for error model parameters: -a.1 b.1 - 1 1 - -Results: - -Likelihood computed by importance sampling - AIC BIC logLik - 667.1 665 -323.6 - -Optimised parameters: - est. lower upper -DMTA_0 97.76570 95.81350 99.71791 -k1 0.05855 0.03080 0.08630 -k2 0.02337 0.01664 0.03010 -tb 31.09638 29.38289 32.80987 -a.1 1.08835 0.88590 1.29080 -b.1 0.02964 0.02257 0.03671 -SD.DMTA_0 2.04877 0.42607 3.67147 -SD.k1 0.59166 0.25621 0.92711 -SD.k2 0.30698 0.09561 0.51835 -SD.tb 0.01274 -0.10914 0.13462 - -Correlation: - DMTA_0 k1 k2 -k1 0.0160 -k2 -0.0070 -0.0024 -tb -0.0668 -0.0103 -0.2013 - -Random effects: - est. lower upper -SD.DMTA_0 2.04877 0.42607 3.6715 -SD.k1 0.59166 0.25621 0.9271 -SD.k2 0.30698 0.09561 0.5183 -SD.tb 0.01274 -0.10914 0.1346 - -Variance model: - est. lower upper -a.1 1.08835 0.88590 1.29080 -b.1 0.02964 0.02257 0.03671 - -Estimated disappearance times: - DT50 DT90 DT50back DT50_k1 DT50_k2 -DMTA 11.84 51.71 15.57 11.84 29.66 - -</code></pre> -<p></p> -</div> -<div class="section level3"> -<h3 id="hierarchical-model-convergence-plots">Hierarchical model convergence plots<a class="anchor" aria-label="anchor" href="#hierarchical-model-convergence-plots"></a> -</h3> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-sfo-const-1.png" alt="Convergence plot for the NLHM SFO fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM SFO fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-sfo-tc-1.png" alt="Convergence plot for the NLHM SFO fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM SFO fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-fomc-const-1.png" alt="Convergence plot for the NLHM FOMC fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM FOMC fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-fomc-tc-1.png" alt="Convergence plot for the NLHM FOMC fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM FOMC fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png" alt="Convergence plot for the NLHM DFOP fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-dfop-tc-1.png" alt="Convergence plot for the NLHM DFOP fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM DFOP fit with two-component error -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-hs-const-1.png" alt="Convergence plot for the NLHM HS fit with constant variance" width="864"><p class="caption"> -Convergence plot for the NLHM HS fit with constant variance -</p> -</div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_parent_files/figure-html/convergence-saem-hs-tc-1.png" alt="Convergence plot for the NLHM HS fit with two-component error" width="864"><p class="caption"> -Convergence plot for the NLHM HS fit with two-component error -</p> -</div> -</div> -<div class="section level3"> -<h3 id="session-info">Session info<a class="anchor" aria-label="anchor" href="#session-info"></a> -</h3> -<pre><code>R version 4.2.2 Patched (2022-11-10 r83330) -Platform: x86_64-pc-linux-gnu (64-bit) -Running under: Debian GNU/Linux bookworm/sid - -Matrix products: default -BLAS: /usr/lib/x86_64-linux-gnu/openblas-serial/libblas.so.3 -LAPACK: /usr/lib/x86_64-linux-gnu/openblas-serial/libopenblas-r0.3.21.so - -locale: - [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C - [3] LC_TIME=de_DE.UTF-8 LC_COLLATE=de_DE.UTF-8 - [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8 - [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C - [9] LC_ADDRESS=C LC_TELEPHONE=C -[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C - -attached base packages: -[1] parallel stats graphics grDevices utils datasets methods -[8] base - -other attached packages: -[1] saemix_3.2 npde_3.3 knitr_1.41 mkin_1.2.2 - -loaded via a namespace (and not attached): - [1] deSolve_1.34 zoo_1.8-11 tidyselect_1.2.0 xfun_0.35 - [5] bslib_0.4.2 purrr_1.0.0 lattice_0.20-45 colorspace_2.0-3 - [9] vctrs_0.5.1 generics_0.1.3 htmltools_0.5.4 yaml_2.3.6 -[13] utf8_1.2.2 rlang_1.0.6 pkgdown_2.0.7 jquerylib_0.1.4 -[17] pillar_1.8.1 glue_1.6.2 DBI_1.1.3 lifecycle_1.0.3 -[21] stringr_1.5.0 munsell_0.5.0 gtable_0.3.1 ragg_1.2.4 -[25] codetools_0.2-18 memoise_2.0.1 evaluate_0.19 fastmap_1.1.0 -[29] lmtest_0.9-40 fansi_1.0.3 highr_0.9 scales_1.2.1 -[33] cachem_1.0.6 desc_1.4.2 jsonlite_1.8.4 systemfonts_1.0.4 -[37] fs_1.5.2 textshaping_0.3.6 gridExtra_2.3 ggplot2_3.4.0 -[41] digest_0.6.31 stringi_1.7.8 dplyr_1.0.10 grid_4.2.2 -[45] rprojroot_2.0.3 cli_3.5.0 tools_4.2.2 magrittr_2.0.3 -[49] sass_0.4.4 tibble_3.1.8 pkgconfig_2.0.3 assertthat_0.2.1 -[53] rmarkdown_2.19 R6_2.5.1 mclust_6.0.0 nlme_3.1-161 -[57] compiler_4.2.2 </code></pre> -</div> -<div class="section level3"> -<h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a> -</h3> -<pre><code>CPU model: AMD Ryzen 9 7950X 16-Core Processor</code></pre> -<pre><code>MemTotal: 64940452 kB</code></pre> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/prebuilt/2022_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png b/docs/dev/articles/prebuilt/2022_dmta_parent_files/figure-html/convergence-saem-dfop-const-1.png Binary files differdeleted file mode 100644 index 3f145074..00000000 --- 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fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Testing hierarchical pathway kinetics with -residue data on dimethenamid and dimethenamid-P</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change on 20 April 2023, -last compiled on 20 April 2023</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/prebuilt/2022_dmta_pathway.rmd" class="external-link"><code>vignettes/prebuilt/2022_dmta_pathway.rmd</code></a></small> - <div class="hidden name"><code>2022_dmta_pathway.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>The purpose of this document is to test demonstrate how nonlinear -hierarchical models (NLHM) based on the parent degradation models SFO, -FOMC, DFOP and HS, with parallel formation of two or more metabolites -can be fitted with the mkin package.</p> -<p>It was assembled in the course of work package 1.2 of Project Number -173340 (Application of nonlinear hierarchical models to the kinetic -evaluation of chemical degradation data) of the German Environment -Agency carried out in 2022 and 2023.</p> -<p>The mkin package is used in version 1.2.4, which is currently under -development. It contains the test data, and the functions used in the -evaluations. The <code>saemix</code> package is used as a backend for -fitting the NLHM, but is also loaded to make the convergence plot -function available.</p> -<p>This document is processed with the <code>knitr</code> package, which -also provides the <code>kable</code> function that is used to improve -the display of tabular data in R markdown documents. For parallel -processing, the <code>parallel</code> package is used.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://yihui.org/knitr/" class="external-link">knitr</a></span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> -<span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">parallel</span><span class="op">)</span></span> -<span><span class="va">n_cores</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># We need to start a new cluster after defining a compiled model that is</span></span> -<span><span class="co"># saved as a DLL to the user directory, therefore we define a function</span></span> -<span><span class="co"># This is used again after defining the pathway model</span></span> -<span><span class="va">start_cluster</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ret</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span> <span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">ret</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makeForkCluster</a></span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span> <span class="op">}</span></span> -<span> <span class="kw"><a href="https://rdrr.io/r/base/function.html" class="external-link">return</a></span><span class="op">(</span><span class="va">ret</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="data">Data<a class="anchor" aria-label="anchor" href="#data"></a> -</h2> -<p>The test data are available in the mkin package as an object of class -<code>mkindsg</code> (mkin dataset group) under the identifier -<code>dimethenamid_2018</code>. The following preprocessing steps are -done in this document.</p> -<ul> -<li>The data available for the enantiomer dimethenamid-P (DMTAP) are -renamed to have the same substance name as the data for the racemic -mixture dimethenamid (DMTA). The reason for this is that no difference -between their degradation behaviour was identified in the EU risk -assessment.</li> -<li>Unnecessary columns are discarded</li> -<li>The observation times of each dataset are multiplied with the -corresponding normalisation factor also available in the dataset, in -order to make it possible to describe all datasets with a single set of -parameters that are independent of temperature</li> -<li>Finally, datasets observed in the same soil (<code>Elliot 1</code> -and <code>Elliot 2</code>) are combined, resulting in dimethenamid -(DMTA) data from six soils.</li> -</ul> -<p>The following commented R code performs this preprocessing.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="co"># Apply a function to each of the seven datasets in the mkindsg object to create a list</span></span> -<span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span> <span class="co"># Get a dataset</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span> <span class="co"># Rename DMTAP to DMTA</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">ds_i</span>, select <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">)</span> <span class="co"># Select data</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span> <span class="co"># Normalise time</span></span> -<span> <span class="va">ds_i</span> <span class="co"># Return the dataset</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Use dataset titles as names for the list elements</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># Combine data for Elliot soil to obtain a named list with six elements</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> <span class="co">#</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -<p>The following tables show the 6 datasets.</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">for</span> <span class="op">(</span><span class="va">ds_name</span> <span class="kw">in</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span></span> -<span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mkin_long_to_wide.html">mkin_long_to_wide</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="va">ds_name</span><span class="op">]</span><span class="op">]</span><span class="op">)</span>,</span> -<span> caption <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="va">ds_name</span><span class="op">)</span>,</span> -<span> booktabs <span class="op">=</span> <span class="cn">TRUE</span>, row.names <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span><span class="st">"\n\\clearpage\n"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<table class="table"> -<caption>Dataset Calke</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0</td> -<td align="right">95.8</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0</td> -<td align="right">98.7</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">14</td> -<td align="right">60.5</td> -<td align="right">4.1</td> -<td align="right">1.5</td> -<td align="right">2.0</td> -</tr> -<tr class="even"> -<td align="right">30</td> -<td align="right">39.1</td> -<td align="right">5.3</td> -<td align="right">2.4</td> -<td align="right">2.1</td> -</tr> -<tr class="odd"> -<td align="right">59</td> -<td align="right">15.2</td> -<td align="right">6.0</td> -<td align="right">3.2</td> -<td align="right">2.2</td> -</tr> -<tr class="even"> -<td align="right">120</td> -<td align="right">4.8</td> -<td align="right">4.3</td> -<td align="right">3.8</td> -<td align="right">1.8</td> -</tr> -<tr class="odd"> -<td align="right">120</td> -<td align="right">4.6</td> -<td align="right">4.1</td> -<td align="right">3.7</td> -<td align="right">2.1</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Borstel</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">100.5</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">99.6</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">1.941295</td> -<td align="right">91.9</td> -<td align="right">0.4</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">1.941295</td> -<td align="right">91.3</td> -<td align="right">0.5</td> -<td align="right">0.3</td> -<td align="right">0.1</td> -</tr> -<tr class="odd"> -<td align="right">6.794534</td> -<td align="right">81.8</td> -<td align="right">1.2</td> -<td align="right">0.8</td> -<td align="right">1.0</td> -</tr> -<tr class="even"> -<td align="right">6.794534</td> -<td align="right">82.1</td> -<td align="right">1.3</td> -<td align="right">0.9</td> -<td align="right">0.9</td> -</tr> -<tr class="odd"> -<td align="right">13.589067</td> -<td align="right">69.1</td> -<td align="right">2.8</td> -<td align="right">1.4</td> -<td align="right">2.0</td> -</tr> -<tr class="even"> -<td align="right">13.589067</td> -<td align="right">68.0</td> -<td align="right">2.0</td> -<td align="right">1.4</td> -<td align="right">2.5</td> -</tr> -<tr class="odd"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -<td align="right">2.9</td> -<td align="right">2.7</td> -<td align="right">4.3</td> -</tr> -<tr class="even"> -<td align="right">27.178135</td> -<td align="right">51.4</td> -<td align="right">4.9</td> -<td align="right">2.6</td> -<td align="right">3.2</td> -</tr> -<tr class="odd"> -<td align="right">56.297565</td> -<td align="right">27.6</td> -<td align="right">12.2</td> -<td align="right">4.4</td> -<td align="right">4.3</td> -</tr> -<tr class="even"> -<td align="right">56.297565</td> -<td align="right">26.8</td> -<td align="right">12.2</td> -<td align="right">4.7</td> -<td align="right">4.8</td> -</tr> -<tr class="odd"> -<td align="right">86.387643</td> -<td align="right">15.7</td> -<td align="right">12.2</td> -<td align="right">5.4</td> -<td align="right">5.0</td> -</tr> -<tr class="even"> -<td align="right">86.387643</td> -<td align="right">15.3</td> -<td align="right">12.0</td> -<td align="right">5.2</td> -<td align="right">5.1</td> -</tr> -<tr class="odd"> -<td align="right">115.507073</td> -<td align="right">7.9</td> -<td align="right">10.4</td> -<td align="right">5.4</td> -<td align="right">4.3</td> -</tr> -<tr class="even"> -<td align="right">115.507073</td> -<td align="right">8.1</td> -<td align="right">11.6</td> -<td align="right">5.4</td> -<td align="right">4.4</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Flaach</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">96.5</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">96.8</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">97.0</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">82.9</td> -<td align="right">0.7</td> -<td align="right">1.1</td> -<td align="right">0.3</td> -</tr> -<tr class="odd"> -<td align="right">0.6233856</td> -<td align="right">86.7</td> -<td align="right">0.7</td> -<td align="right">1.1</td> -<td align="right">0.3</td> -</tr> -<tr class="even"> -<td align="right">0.6233856</td> -<td align="right">87.4</td> -<td align="right">0.2</td> -<td align="right">0.3</td> -<td align="right">0.1</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">72.8</td> -<td align="right">2.2</td> -<td align="right">2.6</td> -<td align="right">0.7</td> -</tr> -<tr class="even"> -<td align="right">1.8701567</td> -<td align="right">69.9</td> -<td align="right">1.8</td> -<td align="right">2.4</td> -<td align="right">0.6</td> -</tr> -<tr class="odd"> -<td align="right">1.8701567</td> -<td align="right">71.9</td> -<td align="right">1.6</td> -<td align="right">2.3</td> -<td align="right">0.7</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">51.4</td> -<td align="right">4.1</td> -<td align="right">5.0</td> -<td align="right">1.3</td> -</tr> -<tr class="odd"> -<td align="right">4.3636989</td> -<td align="right">52.9</td> -<td align="right">4.2</td> -<td align="right">5.9</td> -<td align="right">1.2</td> -</tr> -<tr class="even"> -<td align="right">4.3636989</td> -<td align="right">48.6</td> -<td align="right">4.2</td> -<td align="right">4.8</td> -<td align="right">1.4</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">28.5</td> -<td align="right">7.5</td> -<td align="right">8.5</td> -<td align="right">2.4</td> -</tr> -<tr class="even"> -<td align="right">8.7273979</td> -<td align="right">27.3</td> -<td align="right">7.1</td> -<td align="right">8.5</td> -<td align="right">2.1</td> -</tr> -<tr class="odd"> -<td align="right">8.7273979</td> -<td align="right">27.5</td> -<td align="right">7.5</td> -<td align="right">8.3</td> -<td align="right">2.3</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.8</td> -<td align="right">8.4</td> -<td align="right">9.3</td> -<td align="right">3.3</td> -</tr> -<tr class="odd"> -<td align="right">13.0910968</td> -<td align="right">13.4</td> -<td align="right">6.8</td> -<td align="right">8.7</td> -<td align="right">2.4</td> -</tr> -<tr class="even"> -<td align="right">13.0910968</td> -<td align="right">14.4</td> -<td align="right">8.0</td> -<td align="right">9.1</td> -<td align="right">2.6</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">7.7</td> -<td align="right">7.2</td> -<td align="right">8.6</td> -<td align="right">4.0</td> -</tr> -<tr class="even"> -<td align="right">17.4547957</td> -<td align="right">7.3</td> -<td align="right">7.2</td> -<td align="right">8.5</td> -<td align="right">3.6</td> -</tr> -<tr class="odd"> -<td align="right">17.4547957</td> -<td align="right">8.1</td> -<td align="right">6.9</td> -<td align="right">8.9</td> -<td align="right">3.3</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">2.0</td> -<td align="right">4.9</td> -<td align="right">8.1</td> -<td align="right">2.1</td> -</tr> -<tr class="odd"> -<td align="right">26.1821936</td> -<td align="right">1.5</td> -<td align="right">4.3</td> -<td align="right">7.7</td> -<td align="right">1.7</td> -</tr> -<tr class="even"> -<td align="right">26.1821936</td> -<td align="right">1.9</td> -<td align="right">4.5</td> -<td align="right">7.4</td> -<td align="right">1.8</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.3</td> -<td align="right">3.8</td> -<td align="right">5.9</td> -<td align="right">1.6</td> -</tr> -<tr class="even"> -<td align="right">34.9095915</td> -<td align="right">1.0</td> -<td align="right">3.1</td> -<td align="right">6.0</td> -<td align="right">1.6</td> -</tr> -<tr class="odd"> -<td align="right">34.9095915</td> -<td align="right">1.1</td> -<td align="right">3.1</td> -<td align="right">5.9</td> -<td align="right">1.4</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.9</td> -<td align="right">2.7</td> -<td align="right">5.6</td> -<td align="right">1.8</td> -</tr> -<tr class="odd"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -<td align="right">2.3</td> -<td align="right">5.2</td> -<td align="right">1.5</td> -</tr> -<tr class="even"> -<td align="right">43.6369893</td> -<td align="right">0.7</td> -<td align="right">2.1</td> -<td align="right">5.6</td> -<td align="right">1.3</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.6</td> -<td align="right">1.6</td> -<td align="right">4.3</td> -<td align="right">1.2</td> -</tr> -<tr class="even"> -<td align="right">52.3643872</td> -<td align="right">0.4</td> -<td align="right">1.1</td> -<td align="right">3.7</td> -<td align="right">0.9</td> -</tr> -<tr class="odd"> -<td align="right">52.3643872</td> -<td align="right">0.5</td> -<td align="right">1.3</td> -<td align="right">3.9</td> -<td align="right">1.1</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.4</td> -<td align="right">0.4</td> -<td align="right">2.5</td> -<td align="right">0.5</td> -</tr> -<tr class="odd"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -<td align="right">0.4</td> -<td align="right">2.4</td> -<td align="right">0.5</td> -</tr> -<tr class="even"> -<td align="right">74.8062674</td> -<td align="right">0.3</td> -<td align="right">0.3</td> -<td align="right">2.2</td> -<td align="right">0.3</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.2</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">98.09</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">98.77</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">0.7678922</td> -<td align="right">93.52</td> -<td align="right">0.36</td> -<td align="right">0.42</td> -<td align="right">0.36</td> -</tr> -<tr class="even"> -<td align="right">0.7678922</td> -<td align="right">92.03</td> -<td align="right">0.40</td> -<td align="right">0.47</td> -<td align="right">0.33</td> -</tr> -<tr class="odd"> -<td align="right">2.3036765</td> -<td align="right">88.39</td> -<td align="right">1.03</td> -<td align="right">0.71</td> -<td align="right">0.55</td> -</tr> -<tr class="even"> -<td align="right">2.3036765</td> -<td align="right">87.18</td> -<td align="right">1.07</td> -<td align="right">0.82</td> -<td align="right">0.64</td> -</tr> -<tr class="odd"> -<td align="right">5.3752452</td> -<td align="right">69.38</td> -<td align="right">3.60</td> -<td align="right">2.19</td> -<td align="right">1.94</td> -</tr> -<tr class="even"> -<td align="right">5.3752452</td> -<td align="right">71.06</td> -<td align="right">3.66</td> -<td align="right">2.28</td> -<td align="right">1.62</td> -</tr> -<tr class="odd"> -<td align="right">10.7504904</td> -<td align="right">45.21</td> -<td align="right">6.97</td> -<td align="right">5.45</td> -<td align="right">4.22</td> -</tr> -<tr class="even"> -<td align="right">10.7504904</td> -<td align="right">46.81</td> -<td align="right">7.22</td> -<td align="right">5.19</td> -<td align="right">4.37</td> -</tr> -<tr class="odd"> -<td align="right">16.1257355</td> -<td align="right">30.54</td> -<td align="right">8.65</td> -<td align="right">8.81</td> -<td align="right">6.31</td> -</tr> -<tr class="even"> -<td align="right">16.1257355</td> -<td align="right">30.07</td> -<td align="right">8.38</td> -<td align="right">7.93</td> -<td align="right">6.85</td> -</tr> -<tr class="odd"> -<td align="right">21.5009807</td> -<td align="right">21.60</td> -<td align="right">9.10</td> -<td align="right">10.25</td> -<td align="right">7.05</td> -</tr> -<tr class="even"> -<td align="right">21.5009807</td> -<td align="right">20.41</td> -<td align="right">8.63</td> -<td align="right">10.77</td> -<td align="right">6.84</td> -</tr> -<tr class="odd"> -<td align="right">32.2514711</td> -<td align="right">9.10</td> -<td align="right">7.63</td> -<td align="right">10.89</td> -<td align="right">6.53</td> -</tr> -<tr class="even"> -<td align="right">32.2514711</td> -<td align="right">9.70</td> -<td align="right">8.01</td> -<td align="right">10.85</td> -<td align="right">7.11</td> -</tr> -<tr class="odd"> -<td align="right">43.0019614</td> -<td align="right">6.58</td> -<td align="right">6.40</td> -<td align="right">10.41</td> -<td align="right">6.06</td> -</tr> -<tr class="even"> -<td align="right">43.0019614</td> -<td align="right">6.31</td> -<td align="right">6.35</td> -<td align="right">10.35</td> -<td align="right">6.05</td> -</tr> -<tr class="odd"> -<td align="right">53.7524518</td> -<td align="right">3.47</td> -<td align="right">5.35</td> -<td align="right">9.92</td> -<td align="right">5.50</td> -</tr> -<tr class="even"> -<td align="right">53.7524518</td> -<td align="right">3.52</td> -<td align="right">5.06</td> -<td align="right">9.42</td> -<td align="right">5.07</td> -</tr> -<tr class="odd"> -<td align="right">64.5029421</td> -<td align="right">3.40</td> -<td align="right">5.14</td> -<td align="right">9.15</td> -<td align="right">4.94</td> -</tr> -<tr class="even"> -<td align="right">64.5029421</td> -<td align="right">3.67</td> -<td align="right">5.91</td> -<td align="right">9.25</td> -<td align="right">4.39</td> -</tr> -<tr class="odd"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -<td align="right">3.35</td> -<td align="right">7.14</td> -<td align="right">3.64</td> -</tr> -<tr class="even"> -<td align="right">91.3791680</td> -<td align="right">1.62</td> -<td align="right">2.87</td> -<td align="right">7.13</td> -<td align="right">3.55</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset BBA 2.3</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.0000000</td> -<td align="right">99.33</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.0000000</td> -<td align="right">97.44</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">0.6733938</td> -<td align="right">93.73</td> -<td align="right">0.18</td> -<td align="right">0.50</td> -<td align="right">0.47</td> -</tr> -<tr class="even"> -<td align="right">0.6733938</td> -<td align="right">93.77</td> -<td align="right">0.18</td> -<td align="right">0.83</td> -<td align="right">0.34</td> -</tr> -<tr class="odd"> -<td align="right">2.0201814</td> -<td align="right">87.84</td> -<td align="right">0.52</td> -<td align="right">1.25</td> -<td align="right">1.00</td> -</tr> -<tr class="even"> -<td align="right">2.0201814</td> -<td align="right">89.82</td> -<td align="right">0.43</td> -<td align="right">1.09</td> -<td align="right">0.89</td> -</tr> -<tr class="odd"> -<td align="right">4.7137565</td> -<td align="right">71.61</td> -<td align="right">1.19</td> -<td align="right">3.28</td> -<td align="right">3.58</td> -</tr> -<tr class="even"> -<td align="right">4.7137565</td> -<td align="right">71.42</td> -<td align="right">1.11</td> -<td align="right">3.24</td> -<td align="right">3.41</td> -</tr> -<tr class="odd"> -<td align="right">9.4275131</td> -<td align="right">45.60</td> -<td align="right">2.26</td> -<td align="right">7.17</td> -<td align="right">8.74</td> -</tr> -<tr class="even"> -<td align="right">9.4275131</td> -<td align="right">45.42</td> -<td align="right">1.99</td> -<td align="right">7.91</td> -<td align="right">8.28</td> -</tr> -<tr class="odd"> -<td align="right">14.1412696</td> -<td align="right">31.12</td> -<td align="right">2.81</td> -<td align="right">10.15</td> -<td align="right">9.67</td> -</tr> -<tr class="even"> -<td align="right">14.1412696</td> -<td align="right">31.68</td> -<td align="right">2.83</td> -<td align="right">9.55</td> -<td align="right">8.95</td> -</tr> -<tr class="odd"> -<td align="right">18.8550262</td> -<td align="right">23.20</td> -<td align="right">3.39</td> -<td align="right">12.09</td> -<td align="right">10.34</td> -</tr> -<tr class="even"> -<td align="right">18.8550262</td> -<td align="right">24.13</td> -<td align="right">3.56</td> -<td align="right">11.89</td> -<td align="right">10.00</td> -</tr> -<tr class="odd"> -<td align="right">28.2825393</td> -<td align="right">9.43</td> -<td align="right">3.49</td> -<td align="right">13.32</td> -<td align="right">7.89</td> -</tr> -<tr class="even"> -<td align="right">28.2825393</td> -<td align="right">9.82</td> -<td align="right">3.28</td> -<td align="right">12.05</td> -<td align="right">8.13</td> -</tr> -<tr class="odd"> -<td align="right">37.7100523</td> -<td align="right">7.08</td> -<td align="right">2.80</td> -<td align="right">10.04</td> -<td align="right">5.06</td> -</tr> -<tr class="even"> -<td align="right">37.7100523</td> -<td align="right">8.64</td> -<td align="right">2.97</td> -<td align="right">10.78</td> -<td align="right">5.54</td> -</tr> -<tr class="odd"> -<td align="right">47.1375654</td> -<td align="right">4.41</td> -<td align="right">2.42</td> -<td align="right">9.32</td> -<td align="right">3.79</td> -</tr> -<tr class="even"> -<td align="right">47.1375654</td> -<td align="right">4.78</td> -<td align="right">2.51</td> -<td align="right">9.62</td> -<td align="right">4.11</td> -</tr> -<tr class="odd"> -<td align="right">56.5650785</td> -<td align="right">4.92</td> -<td align="right">2.22</td> -<td align="right">8.00</td> -<td align="right">3.11</td> -</tr> -<tr class="even"> -<td align="right">56.5650785</td> -<td align="right">5.08</td> -<td align="right">1.95</td> -<td align="right">8.45</td> -<td align="right">2.98</td> -</tr> -<tr class="odd"> -<td align="right">80.1338612</td> -<td align="right">2.13</td> -<td align="right">1.28</td> -<td align="right">5.71</td> -<td align="right">1.78</td> -</tr> -<tr class="even"> -<td align="right">80.1338612</td> -<td align="right">2.23</td> -<td align="right">0.99</td> -<td align="right">3.33</td> -<td align="right">1.55</td> -</tr> -</tbody> -</table> -<table class="table"> -<caption>Dataset Elliot</caption> -<thead><tr class="header"> -<th align="right">time</th> -<th align="right">DMTA</th> -<th align="right">M23</th> -<th align="right">M27</th> -<th align="right">M31</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">97.5</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">100.7</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">86.4</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">88.5</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">1.5</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">69.8</td> -<td align="right">2.8</td> -<td align="right">2.3</td> -<td align="right">5.0</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">77.1</td> -<td align="right">1.7</td> -<td align="right">2.1</td> -<td align="right">2.4</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">59.0</td> -<td align="right">4.3</td> -<td align="right">4.0</td> -<td align="right">4.3</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">54.2</td> -<td align="right">5.8</td> -<td align="right">3.4</td> -<td align="right">5.0</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">31.3</td> -<td align="right">8.2</td> -<td align="right">6.6</td> -<td align="right">8.0</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.5</td> -<td align="right">5.2</td> -<td align="right">6.9</td> -<td align="right">7.7</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">19.6</td> -<td align="right">5.1</td> -<td align="right">8.2</td> -<td align="right">7.8</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -<td align="right">6.1</td> -<td align="right">8.8</td> -<td align="right">6.5</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">13.3</td> -<td align="right">6.0</td> -<td align="right">9.7</td> -<td align="right">8.0</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">15.8</td> -<td align="right">6.0</td> -<td align="right">8.8</td> -<td align="right">7.4</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">6.7</td> -<td align="right">5.0</td> -<td align="right">8.3</td> -<td align="right">6.9</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">8.7</td> -<td align="right">4.2</td> -<td align="right">9.2</td> -<td align="right">9.0</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">8.8</td> -<td align="right">3.9</td> -<td align="right">9.3</td> -<td align="right">5.5</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">8.7</td> -<td align="right">2.9</td> -<td align="right">8.5</td> -<td align="right">6.1</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">6.0</td> -<td align="right">1.9</td> -<td align="right">8.6</td> -<td align="right">6.1</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -<td align="right">1.5</td> -<td align="right">6.0</td> -<td align="right">4.0</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">3.3</td> -<td align="right">2.0</td> -<td align="right">5.6</td> -<td align="right">3.1</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">2.8</td> -<td align="right">2.3</td> -<td align="right">4.5</td> -<td align="right">2.9</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">1.4</td> -<td align="right">1.2</td> -<td align="right">4.1</td> -<td align="right">1.8</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.8</td> -<td align="right">1.9</td> -<td align="right">3.9</td> -<td align="right">2.6</td> -</tr> -<tr class="odd"> -<td align="right">0.000000</td> -<td align="right">93.4</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="even"> -<td align="right">0.000000</td> -<td align="right">103.2</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">1.228478</td> -<td align="right">89.2</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">1.3</td> -</tr> -<tr class="even"> -<td align="right">1.228478</td> -<td align="right">86.6</td> -<td align="right">NA</td> -<td align="right">NA</td> -<td align="right">NA</td> -</tr> -<tr class="odd"> -<td align="right">3.685435</td> -<td align="right">78.2</td> -<td align="right">2.6</td> -<td align="right">1.0</td> -<td align="right">3.1</td> -</tr> -<tr class="even"> -<td align="right">3.685435</td> -<td align="right">78.1</td> -<td align="right">2.4</td> -<td align="right">2.6</td> -<td align="right">2.3</td> -</tr> -<tr class="odd"> -<td align="right">8.599349</td> -<td align="right">55.6</td> -<td align="right">5.5</td> -<td align="right">4.5</td> -<td align="right">3.4</td> -</tr> -<tr class="even"> -<td align="right">8.599349</td> -<td align="right">53.0</td> -<td align="right">5.6</td> -<td align="right">4.6</td> -<td align="right">4.3</td> -</tr> -<tr class="odd"> -<td align="right">17.198697</td> -<td align="right">33.7</td> -<td align="right">7.3</td> -<td align="right">7.6</td> -<td align="right">7.8</td> -</tr> -<tr class="even"> -<td align="right">17.198697</td> -<td align="right">33.2</td> -<td align="right">6.5</td> -<td align="right">6.7</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">25.798046</td> -<td align="right">20.9</td> -<td align="right">5.8</td> -<td align="right">8.7</td> -<td align="right">7.7</td> -</tr> -<tr class="even"> -<td align="right">25.798046</td> -<td align="right">19.9</td> -<td align="right">7.7</td> -<td align="right">7.6</td> -<td align="right">6.5</td> -</tr> -<tr class="odd"> -<td align="right">34.397395</td> -<td align="right">18.2</td> -<td align="right">7.8</td> -<td align="right">8.0</td> -<td align="right">6.3</td> -</tr> -<tr class="even"> -<td align="right">34.397395</td> -<td align="right">12.7</td> -<td align="right">7.3</td> -<td align="right">8.6</td> -<td align="right">8.7</td> -</tr> -<tr class="odd"> -<td align="right">51.596092</td> -<td align="right">7.8</td> -<td align="right">7.0</td> -<td align="right">7.4</td> -<td align="right">5.7</td> -</tr> -<tr class="even"> -<td align="right">51.596092</td> -<td align="right">9.0</td> -<td align="right">6.3</td> -<td align="right">7.2</td> -<td align="right">4.2</td> -</tr> -<tr class="odd"> -<td align="right">68.794789</td> -<td align="right">11.4</td> -<td align="right">4.3</td> -<td align="right">10.3</td> -<td align="right">3.2</td> -</tr> -<tr class="even"> -<td align="right">68.794789</td> -<td align="right">9.0</td> -<td align="right">3.8</td> -<td align="right">9.4</td> -<td align="right">4.2</td> -</tr> -<tr class="odd"> -<td align="right">103.192184</td> -<td align="right">3.9</td> -<td align="right">2.6</td> -<td align="right">6.5</td> -<td align="right">3.8</td> -</tr> -<tr class="even"> -<td align="right">103.192184</td> -<td align="right">4.4</td> -<td align="right">2.8</td> -<td align="right">6.9</td> -<td align="right">4.0</td> -</tr> -<tr class="odd"> -<td align="right">146.188928</td> -<td align="right">2.6</td> -<td align="right">1.6</td> -<td align="right">4.6</td> -<td align="right">4.5</td> -</tr> -<tr class="even"> -<td align="right">146.188928</td> -<td align="right">3.4</td> -<td align="right">1.1</td> -<td align="right">4.5</td> -<td align="right">4.5</td> -</tr> -<tr class="odd"> -<td align="right">223.583066</td> -<td align="right">2.0</td> -<td align="right">1.4</td> -<td align="right">4.3</td> -<td align="right">3.8</td> -</tr> -<tr class="even"> -<td align="right">223.583066</td> -<td align="right">1.7</td> -<td align="right">1.3</td> -<td align="right">4.2</td> -<td align="right">2.3</td> -</tr> -</tbody> -</table> -</div> -<div class="section level2"> -<h2 id="separate-evaluations">Separate evaluations<a class="anchor" aria-label="anchor" href="#separate-evaluations"></a> -</h2> -<p>As a first step to obtain suitable starting parameters for the NLHM -fits, we do separate fits of several variants of the pathway model used -previously <span class="citation">(Ranke et al. 2021)</span>, varying -the kinetic model for the parent compound. Because the SFORB model often -provides faster convergence than the DFOP model, and can sometimes be -fitted where the DFOP model results in errors, it is included in the set -of parent models tested here.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.exists</a></span><span class="op">(</span><span class="st">"dmta_dlls"</span><span class="op">)</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.create</a></span><span class="op">(</span><span class="st">"dmta_dlls"</span><span class="op">)</span></span> -<span><span class="va">m_sfo_path_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"m_sfo_path"</span>, dll_dir <span class="op">=</span> <span class="st">"dmta_dlls"</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span><span class="va">m_fomc_path_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"m_fomc_path"</span>, dll_dir <span class="op">=</span> <span class="st">"dmta_dlls"</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span><span class="va">m_dfop_path_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"m_dfop_path"</span>, dll_dir <span class="op">=</span> <span class="st">"dmta_dlls"</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span><span class="va">m_sforb_path_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"m_sforb_path"</span>, dll_dir <span class="op">=</span> <span class="st">"dmta_dlls"</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span><span class="va">m_hs_path_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"HS"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> name <span class="op">=</span> <span class="st">"m_hs_path"</span>, dll_dir <span class="op">=</span> <span class="st">"dmta_dlls"</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span><span class="va">cl</span> <span class="op"><-</span> <span class="fu">start_cluster</span><span class="op">(</span><span class="va">n_cores</span><span class="op">)</span></span> -<span></span> -<span><span class="va">deg_mods_1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span> sfo_path_1 <span class="op">=</span> <span class="va">m_sfo_path_1</span>,</span> -<span> fomc_path_1 <span class="op">=</span> <span class="va">m_fomc_path_1</span>,</span> -<span> dfop_path_1 <span class="op">=</span> <span class="va">m_dfop_path_1</span>,</span> -<span> sforb_path_1 <span class="op">=</span> <span class="va">m_sforb_path_1</span>,</span> -<span> hs_path_1 <span class="op">=</span> <span class="va">m_hs_path_1</span><span class="op">)</span></span> -<span></span> -<span><span class="va">sep_1_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span></span> -<span> <span class="va">deg_mods_1</span>,</span> -<span> <span class="va">dmta_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">sep_1_const</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -</tr> -</tbody> -</table> -<p>All separate pathway fits with SFO or FOMC for the parent and -constant variance converged (status OK). Most fits with DFOP or SFORB -for the parent converged as well. The fits with HS for the parent did -not converge with default settings.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">sep_1_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">sep_1_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">sep_1_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">Calke</th> -<th align="left">Borstel</th> -<th align="left">Flaach</th> -<th align="left">BBA 2.2</th> -<th align="left">BBA 2.3</th> -<th align="left">Elliot</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">C</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">OK</td> -<td align="left">C</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">C</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>With the two-component error model, the set of fits with convergence -problems is slightly different, with convergence problems appearing for -different data sets when applying the DFOP and SFORB model and some -additional convergence problems when using the FOMC model for the -parent.</p> -</div> -<div class="section level2"> -<h2 id="hierarchichal-model-fits">Hierarchichal model fits<a class="anchor" aria-label="anchor" href="#hierarchichal-model-fits"></a> -</h2> -<p>The following code fits two sets of the corresponding hierarchical -models to the data, one assuming constant variance, and one assuming -two-component error.</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">saem_1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mhmkin.html">mhmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">sep_1_const</span>, <span class="va">sep_1_tc</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p>The run time for these fits was around two hours on five year old -hardware. After a recent hardware upgrade these fits complete in less -than twenty minutes.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/status.html">status</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left">OK</td> -<td align="left">OK</td> -</tr> -</tbody> -</table> -<p>According to the <code>status</code> function, all fits terminated -successfully.</p> -<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<pre><code>Warning in FUN(X[[i]], ...): Could not obtain log likelihood with 'is' method -for sforb_path_1 const</code></pre> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1 const</td> -<td align="right">17</td> -<td align="right">2291.8</td> -<td align="right">2288.3</td> -<td align="right">-1128.9</td> -</tr> -<tr class="even"> -<td align="left">sfo_path_1 tc</td> -<td align="right">18</td> -<td align="right">2276.3</td> -<td align="right">2272.5</td> -<td align="right">-1120.1</td> -</tr> -<tr class="odd"> -<td align="left">fomc_path_1 const</td> -<td align="right">19</td> -<td align="right">2099.0</td> -<td align="right">2095.0</td> -<td align="right">-1030.5</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1 tc</td> -<td align="right">20</td> -<td align="right">1939.6</td> -<td align="right">1935.5</td> -<td align="right">-949.8</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1 const</td> -<td align="right">21</td> -<td align="right">2038.8</td> -<td align="right">2034.4</td> -<td align="right">-998.4</td> -</tr> -<tr class="even"> -<td align="left">hs_path_1 const</td> -<td align="right">21</td> -<td align="right">2024.2</td> -<td align="right">2019.8</td> -<td align="right">-991.1</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1 tc</td> -<td align="right">22</td> -<td align="right">1879.8</td> -<td align="right">1875.2</td> -<td align="right">-917.9</td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1 tc</td> -<td align="right">22</td> -<td align="right">1832.9</td> -<td align="right">1828.3</td> -<td align="right">-894.4</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1 tc</td> -<td align="right">22</td> -<td align="right">1831.4</td> -<td align="right">1826.8</td> -<td align="right">-893.7</td> -</tr> -</tbody> -</table> -<p>When the goodness-of-fit of the models is compared, a warning is -obtained, indicating that the likelihood of the pathway fit with SFORB -for the parent compound and constant variance could not be calculated -with importance sampling (method ‘is’). As this is the default method on -which all AIC and BIC comparisons are based, this variant is not -included in the model comparison table. Comparing the goodness-of-fit of -the remaining models, HS model model with two-component error provides -the best fit. However, for batch experiments performed with constant -conditions such as the experiments evaluated here, there is no reason to -assume a discontinuity, so the SFORB model is preferable from a -mechanistic viewpoint. In addition, the information criteria AIC and BIC -are very similar for HS and SFORB. Therefore, the SFORB model is -selected here for further refinements.</p> -<div class="section level3"> -<h3 id="parameter-identifiability-based-on-the-fisher-information-matrix">Parameter identifiability based on the Fisher Information -Matrix<a class="anchor" aria-label="anchor" href="#parameter-identifiability-based-on-the-fisher-information-matrix"></a> -</h3> -<p>Using the <code>illparms</code> function, ill-defined statistical -model parameters such as standard deviations of the degradation -parameters in the population and error model parameters can be -found.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="left">const</th> -<th align="left">tc</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_path_1</td> -<td align="left"></td> -<td align="left">sd(DMTA_0)</td> -</tr> -<tr class="even"> -<td align="left">fomc_path_1</td> -<td align="left"></td> -<td align="left">sd(DMTA_0)</td> -</tr> -<tr class="odd"> -<td align="left">dfop_path_1</td> -<td align="left"></td> -<td align="left"></td> -</tr> -<tr class="even"> -<td align="left">sforb_path_1</td> -<td align="left"></td> -<td align="left">sd(log_k_DMTA_bound_free)</td> -</tr> -<tr class="odd"> -<td align="left">hs_path_1</td> -<td align="left"></td> -<td align="left">sd(log_tb)</td> -</tr> -</tbody> -</table> -<p>When using constant variance, no ill-defined variance parameters are -identified with the <code>illparms</code> function in any of the -degradation models. When using the two-component error model, there is -one ill-defined variance parameter in all variants except for the -variant using DFOP for the parent compound.</p> -<p>For the selected combination of the SFORB pathway model with -two-component error, the random effect for the rate constant from -reversibly bound DMTA to the free DMTA (<code>k_DMTA_bound_free</code>) -is not well-defined. Therefore, the fit is updated without assuming a -random effect for this parameter.</p> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">saem_sforb_path_1_tc_reduced</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"log_k_DMTA_bound_free"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced</span><span class="op">)</span></span></code></pre></div> -<p>As expected, no ill-defined parameters remain. The model comparison -below shows that the reduced model is preferable.</p> -<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span>, <span class="va">saem_sforb_path_1_tc_reduced</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">saem_sforb_path_1_tc_reduced</td> -<td align="right">21</td> -<td align="right">1830.3</td> -<td align="right">1825.9</td> -<td align="right">-894.2</td> -</tr> -<tr class="even"> -<td align="left">saem_1[[“sforb_path_1”, “tc”]]</td> -<td align="right">22</td> -<td align="right">1832.9</td> -<td align="right">1828.3</td> -<td align="right">-894.4</td> -</tr> -</tbody> -</table> -<p>The convergence plot of the refined fit is shown below.</p> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></code></pre></div> -<p><img src="2022_dmta_pathway_files/figure-html/saem-sforb-path-1-tc-reduced-convergence-1.png" width="700" style="display: block; margin: auto;"></p> -<p>For some parameters, for example for <code>f_DMTA_ilr_1</code> and -<code>f_DMTA_ilr_2</code>, i.e. for two of the parameters determining -the formation fractions of the parallel formation of the three -metabolites, some movement of the parameters is still visible in the -second phase of the algorithm. However, the amplitude of this movement -is in the range of the amplitude towards the end of the first phase. -Therefore, it is likely that an increase in iterations would not improve -the parameter estimates very much, and it is proposed that the fit is -acceptable. No numeric convergence criterion is implemented in -saemix.</p> -</div> -<div class="section level3"> -<h3 id="alternative-check-of-parameter-identifiability">Alternative check of parameter identifiability<a class="anchor" aria-label="anchor" href="#alternative-check-of-parameter-identifiability"></a> -</h3> -<p>As an alternative check of parameter identifiability <span class="citation">(Duchesne et al. 2021)</span>, multistart runs were -performed on the basis of the refined fit shown above.</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">saem_sforb_path_1_tc_reduced_multi</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced</span>,</span> -<span> n <span class="op">=</span> <span class="fl">32</span>, cores <span class="op">=</span> <span class="fl">10</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced_multi</span><span class="op">)</span></span></code></pre></div> -<pre><code><multistart> object with 32 fits: - E OK -15 17 -OK: Fit terminated successfully -E: Error</code></pre> -<p>Out of the 32 fits that were initiated, only 17 terminated without an -error. The reason for this is that the wide variation of starting -parameters in combination with the parameter variation that is used in -the SAEM algorithm leads to parameter combinations for the degradation -model that the numerical integration routine cannot cope with. Because -of this variation of initial parameters, some of the model fits take up -to two times more time than the original fit.</p> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/graphics/par.html" class="external-link">par</a></span><span class="op">(</span>mar <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">12.1</span>, <span class="fl">4.1</span>, <span class="fl">2.1</span>, <span class="fl">2.1</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced_multi</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span>, las <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-2-1.png" alt="Parameter boxplots for the multistart runs that succeeded" width="960"><p class="caption"> -Parameter boxplots for the multistart runs that succeeded -</p> -</div> -<p>However, visual analysis of the boxplot of the parameters obtained in -the successful fits confirms that the results are sufficiently -independent of the starting parameters, and there are no remaining -ill-defined parameters.</p> -</div> -</div> -<div class="section level2"> -<h2 id="plots-of-selected-fits">Plots of selected fits<a class="anchor" aria-label="anchor" href="#plots-of-selected-fits"></a> -</h2> -<p>The SFORB pathway fits with full and reduced parameter distribution -model are shown below.</p> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-3-1.png" alt="SFORB pathway fit with two-component error" width="700"><p class="caption"> -SFORB pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_sforb_path_1_tc_reduced</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-4-1.png" alt="SFORB pathway fit with two-component error, reduced parameter model" width="700"><p class="caption"> -SFORB pathway fit with two-component error, reduced parameter model -</p> -</div> -<p>Plots of the remaining fits and listings for all successful fits are -shown in the Appendix.</p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#conclusions"></a> -</h2> -<p>Pathway fits with SFO, FOMC, DFOP, SFORB and HS models for the parent -compound could be successfully performed.</p> -</div> -<div class="section level2"> -<h2 id="acknowledgements">Acknowledgements<a class="anchor" aria-label="anchor" href="#acknowledgements"></a> -</h2> -<p>The helpful comments by Janina Wöltjen of the German Environment -Agency on earlier versions of this document are gratefully -acknowledged.</p> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-duchesne_2021" class="csl-entry"> -Duchesne, Ronan, Anissa Guillemin, Olivier Gandrillon, and Fabien -Crauste. 2021. <span>“Practical Identifiability in the Frame of -Nonlinear Mixed Effects Models: The Example of the in Vitro -Erythropoiesis.”</span> <em>BMC Bioinformatics</em> 22 (478). <a href="https://doi.org/10.1186/s12859-021-04373-4" class="external-link">https://doi.org/10.1186/s12859-021-04373-4</a>. -</div> -<div id="ref-ranke2021" class="csl-entry"> -Ranke, Johannes, Janina Wöltjen, Jana Schmidt, and Emmanuelle Comets. -2021. <span>“Taking Kinetic Evaluations of Degradation Data to the Next -Level with Nonlinear Mixed-Effects Models.”</span> <em>Environments</em> -8 (8). <a href="https://doi.org/10.3390/environments8080071" class="external-link">https://doi.org/10.3390/environments8080071</a>. -</div> -</div> -</div> -<div class="section level2"> -<h2 id="appendix">Appendix<a class="anchor" aria-label="anchor" href="#appendix"></a> -</h2> -<div class="section level3"> -<h3 id="plots-of-hierarchical-fits-not-selected-for-refinement">Plots of hierarchical fits not selected for refinement<a class="anchor" aria-label="anchor" href="#plots-of-hierarchical-fits-not-selected-for-refinement"></a> -</h3> -<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"sfo_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-6-1.png" alt="SFO pathway fit with two-component error" width="700"><p class="caption"> -SFO pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"fomc_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-7-1.png" alt="FOMC pathway fit with two-component error" width="700"><p class="caption"> -FOMC pathway fit with two-component error -</p> -</div> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">saem_1</span><span class="op">[[</span><span class="st">"sforb_path_1"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<div class="figure" style="text-align: center"> -<img src="2022_dmta_pathway_files/figure-html/unnamed-chunk-8-1.png" alt="HS pathway fit with two-component error" width="700"><p class="caption"> -HS pathway fit with two-component error -</p> -</div> -</div> -<div class="section level3"> -<h3 id="hierarchical-model-fit-listings">Hierarchical model fit listings<a class="anchor" aria-label="anchor" href="#hierarchical-model-fit-listings"></a> -</h3> -<div class="section level4"> -<h4 id="fits-with-random-effects-for-all-degradation-parameters">Fits with random effects for all degradation parameters<a class="anchor" aria-label="anchor" href="#fits-with-random-effects-for-all-degradation-parameters"></a> -</h4> - -</div> -<div class="section level4"> -<h4 id="improved-fit-of-the-sforb-pathway-model-with-two-component-error">Improved fit of the SFORB pathway model with two-component -error<a class="anchor" aria-label="anchor" href="#improved-fit-of-the-sforb-pathway-model-with-two-component-error"></a> -</h4> - -</div> -</div> -<div class="section level3"> -<h3 id="session-info">Session info<a class="anchor" aria-label="anchor" href="#session-info"></a> -</h3> -<pre><code>R version 4.2.3 (2023-03-15) -Platform: x86_64-pc-linux-gnu (64-bit) -Running under: Debian GNU/Linux 12 (bookworm) - -Matrix products: default -BLAS: /usr/lib/x86_64-linux-gnu/openblas-serial/libblas.so.3 -LAPACK: /usr/lib/x86_64-linux-gnu/openblas-serial/libopenblas-r0.3.21.so - -locale: - [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C - [3] LC_TIME=de_DE.UTF-8 LC_COLLATE=de_DE.UTF-8 - [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8 - [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C - [9] LC_ADDRESS=C LC_TELEPHONE=C -[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C - -attached base packages: -[1] parallel stats graphics grDevices utils datasets methods -[8] base - -other attached packages: -[1] saemix_3.2 npde_3.3 knitr_1.42 mkin_1.2.4 - -loaded via a namespace (and not attached): - [1] deSolve_1.35 zoo_1.8-12 tidyselect_1.2.0 xfun_0.38 - [5] bslib_0.4.2 purrr_1.0.1 lattice_0.21-8 colorspace_2.1-0 - [9] vctrs_0.6.1 generics_0.1.3 htmltools_0.5.5 yaml_2.3.7 -[13] utf8_1.2.3 rlang_1.1.0 pkgbuild_1.4.0 pkgdown_2.0.7 -[17] jquerylib_0.1.4 pillar_1.9.0 glue_1.6.2 DBI_1.1.3 -[21] lifecycle_1.0.3 stringr_1.5.0 munsell_0.5.0 gtable_0.3.3 -[25] ragg_1.2.5 codetools_0.2-19 memoise_2.0.1 evaluate_0.20 -[29] inline_0.3.19 callr_3.7.3 fastmap_1.1.1 ps_1.7.4 -[33] lmtest_0.9-40 fansi_1.0.4 highr_0.10 scales_1.2.1 -[37] cachem_1.0.7 desc_1.4.2 jsonlite_1.8.4 systemfonts_1.0.4 -[41] fs_1.6.1 textshaping_0.3.6 gridExtra_2.3 ggplot2_3.4.2 -[45] digest_0.6.31 stringi_1.7.12 processx_3.8.0 dplyr_1.1.1 -[49] grid_4.2.3 rprojroot_2.0.3 cli_3.6.1 tools_4.2.3 -[53] magrittr_2.0.3 sass_0.4.5 tibble_3.2.1 crayon_1.5.2 -[57] pkgconfig_2.0.3 prettyunits_1.1.1 rmarkdown_2.21 R6_2.5.1 -[61] mclust_6.0.0 nlme_3.1-162 compiler_4.2.3 </code></pre> -</div> -<div class="section level3"> -<h3 id="hardware-info">Hardware info<a class="anchor" aria-label="anchor" href="#hardware-info"></a> -</h3> -<pre><code>CPU model: AMD Ryzen 9 7950X 16-Core Processor</code></pre> -<pre><code>MemTotal: 64936316 kB</code></pre> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - 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href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Calculation of time weighted average -concentrations with mkin</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 18 September 2019 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/twa.rmd" class="external-link"><code>vignettes/twa.rmd</code></a></small> - <div class="hidden name"><code>twa.rmd</code></div> - - </div> - - - -<p>Since version 0.9.45.1 of the ‘mkin’ package, a function for -calculating time weighted average concentrations for decline kinetics -(<em>i.e.</em> only for the compound applied in the experiment) is -included. Strictly speaking, they are maximum moving window time -weighted average concentrations, <em>i.e.</em> the maximum time weighted -average concentration that can be found when moving a time window of a -specified width over the decline curve.</p> -<p>Time weighted average concentrations for the SFO, FOMC and the DFOP -model are calculated using the formulas given in the FOCUS kinetics -guidance <span class="citation">(FOCUS Work Group on Degradation -Kinetics 2014, 251)</span>:</p> -<p>SFO:</p> -<p><span class="math display">\[c_\textrm{twa} = c_0 \frac{\left( 1 - -e^{- k t} \right)}{ k t} \]</span></p> -<p>FOMC:</p> -<p><span class="math display">\[c_\textrm{twa} = c_0 \frac{\beta}{t (1 - -\alpha)} - \left( \left(\frac{t}{\beta} + 1 \right)^{1 - \alpha} -- 1 \right) \]</span></p> -<p>DFOP:</p> -<p><span class="math display">\[c_\textrm{twa} = \frac{c_0}{t} \left( - \frac{g}{k_1} \left( 1 - e^{- k_1 t} \right) + - \frac{1-g}{k_2} \left( 1 - e^{- k_2 t} \right) \right) \]</span></p> -<p>HS for <span class="math inline">\(t > t_b\)</span>:</p> -<p><span class="math display">\[c_\textrm{twa} = \frac{c_0}{t} \left( - \frac{1}{k_1} \left( 1 - e^{- k_1 t_b} \right) + - \frac{e^{- k_1 t_b}}{k_2} \left( 1 - e^{- k_2 (t - t_b)} -\right) \right) \]</span></p> -<p>Often, the ratio between the time weighted average concentration -<span class="math inline">\(c_\textrm{twa}\)</span> and the initial -concentration <span class="math inline">\(c_0\)</span></p> -<p><span class="math display">\[f_\textrm{twa} = -\frac{c_\textrm{twa}}{c_0}\]</span></p> -<p>is needed. This can be calculated from the fitted initial -concentration <span class="math inline">\(c_0\)</span> and the time -weighted average concentration <span class="math inline">\(c_\textrm{twa}\)</span>, or directly from the -model parameters using the following formulas:</p> -<p>SFO:</p> -<p><span class="math display">\[f_\textrm{twa} = \frac{\left( 1 - e^{- k -t} \right)}{k t} \]</span></p> -<p>FOMC:</p> -<p><span class="math display">\[f_\textrm{twa} = \frac{\beta}{t (1 - -\alpha)} - \left( \left(\frac{t}{\beta} + 1 \right)^{1 - \alpha} -- 1 \right) \]</span></p> -<p>DFOP:</p> -<p><span class="math display">\[f_\textrm{twa} = \frac{1}{t} \left( - \frac{g}{k_1} \left( 1 - e^{- k_1 t} \right) + - \frac{1-g}{k_2} \left( 1 - e^{- k_2 t} \right) \right) \]</span></p> -<p>HS for <span class="math inline">\(t > t_b\)</span>:</p> -<p><span class="math display">\[f_\textrm{twa} = \frac{1}{t} \left( - \frac{1}{k_1} \left( 1 - e^{- k_1 t_b} \right) + - \frac{e^{- k_1 t_b}}{k_2} \left( 1 - e^{- k_2 (t - t_b)} -\right) \right) \]</span></p> -<p>Note that a method for calculating maximum moving window time -weighted average concentrations for a model fitted by ‘mkinfit’ or from -parent decline model parameters is included in the -<code><a href="../reference/max_twa_parent.html">max_twa_parent()</a></code> function. If the same is needed for -metabolites, the function <code><a href="https://pkgdown.jrwb.de/pfm/reference/max_twa.html" class="external-link">pfm::max_twa()</a></code> from the ‘pfm’ -package can be used.</p> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-FOCUSkinetics2014" class="csl-entry"> -FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for -Estimating Persistence and Degradation Kinetics from Environmental Fate -Studies on Pesticides in EU Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>. -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - </div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/twa_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/twa_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/twa_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) --> -// v0.0.1 -// Written by JooYoung Seo (jooyoung@psu.edu) and Atsushi Yasumoto on June 1st, 2020. - -document.addEventListener('DOMContentLoaded', function() { - const codeList = document.getElementsByClassName("sourceCode"); - for (var i = 0; i < codeList.length; i++) { - var linkList = codeList[i].getElementsByTagName('a'); - for (var j = 0; j < linkList.length; j++) { - if (linkList[j].innerHTML === "") { - linkList[j].setAttribute('aria-hidden', 'true'); - } - } - } -}); diff --git a/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.css b/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.css deleted file mode 100644 index 07aee5fc..00000000 --- a/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.css +++ /dev/null @@ -1,4 +0,0 @@ -/* Styles for section anchors */ -a.anchor-section {margin-left: 10px; visibility: hidden; color: inherit;} -a.anchor-section::before {content: '#';} -.hasAnchor:hover a.anchor-section {visibility: visible;} diff --git a/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.js b/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.js deleted file mode 100644 index 570f99a0..00000000 --- a/docs/dev/articles/twa_files/anchor-sections-1.0/anchor-sections.js +++ /dev/null @@ -1,33 +0,0 @@ -// Anchor sections v1.0 written by Atsushi Yasumoto on Oct 3rd, 2020. -document.addEventListener('DOMContentLoaded', function() { - // Do nothing if AnchorJS is used - if (typeof window.anchors === 'object' && anchors.hasOwnProperty('hasAnchorJSLink')) { - return; - } - - const h = document.querySelectorAll('h1, h2, h3, h4, h5, h6'); - - // Do nothing if sections are already anchored - if (Array.from(h).some(x => x.classList.contains('hasAnchor'))) { - return null; - } - - // Use section id when pandoc runs with --section-divs - const section_id = function(x) { - return ((x.classList.contains('section') || (x.tagName === 'SECTION')) - ? x.id : ''); - }; - - // Add anchors - h.forEach(function(x) { - const id = x.id || section_id(x.parentElement); - if (id === '') { - return null; - } - let anchor = document.createElement('a'); - anchor.href = '#' + id; - anchor.classList = ['anchor-section']; - x.classList.add('hasAnchor'); - x.appendChild(anchor); - }); -}); diff --git a/docs/dev/articles/twa_files/header-attrs-2.6/header-attrs.js b/docs/dev/articles/twa_files/header-attrs-2.6/header-attrs.js deleted file mode 100644 index dd57d92e..00000000 --- a/docs/dev/articles/twa_files/header-attrs-2.6/header-attrs.js +++ /dev/null @@ -1,12 +0,0 @@ -// Pandoc 2.9 adds attributes on both header and div. 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-</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Example evaluation of FOCUS dataset Z</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 16 January 2018 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/FOCUS_Z.rmd" class="external-link"><code>vignettes/web_only/FOCUS_Z.rmd</code></a></small> - <div class="hidden name"><code>FOCUS_Z.rmd</code></div> - - </div> - - - -<p><a href="http://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher -Str. 12, 79639 Grenzach-Wyhlen, Germany</a><br><a href="http://chem.uft.uni-bremen.de/ranke" class="external-link">Privatdozent at the -University of Bremen</a></p> -<div class="section level2"> -<h2 id="the-data">The data<a class="anchor" aria-label="anchor" href="#the-data"></a> -</h2> -<p>The following code defines the example dataset from Appendix 7 to the -FOCUS kinetics report <span class="citation">(FOCUS Work Group on -Degradation Kinetics 2014, 354)</span>.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">LOD</span> <span class="op">=</span> <span class="fl">0.5</span></span> -<span><span class="va">FOCUS_2006_Z</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">0.04</span>, <span class="fl">0.125</span>, <span class="fl">0.29</span>, <span class="fl">0.54</span>, <span class="fl">1</span>, <span class="fl">2</span>, <span class="fl">3</span>, <span class="fl">4</span>, <span class="fl">7</span>, <span class="fl">10</span>, <span class="fl">14</span>, <span class="fl">21</span>,</span> -<span> <span class="fl">42</span>, <span class="fl">61</span>, <span class="fl">96</span>, <span class="fl">124</span><span class="op">)</span>,</span> -<span> Z0 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">100</span>, <span class="fl">81.7</span>, <span class="fl">70.4</span>, <span class="fl">51.1</span>, <span class="fl">41.2</span>, <span class="fl">6.6</span>, <span class="fl">4.6</span>, <span class="fl">3.9</span>, <span class="fl">4.6</span>, <span class="fl">4.3</span>, <span class="fl">6.8</span>,</span> -<span> <span class="fl">2.9</span>, <span class="fl">3.5</span>, <span class="fl">5.3</span>, <span class="fl">4.4</span>, <span class="fl">1.2</span>, <span class="fl">0.7</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">18.3</span>, <span class="fl">29.6</span>, <span class="fl">46.3</span>, <span class="fl">55.1</span>, <span class="fl">65.7</span>, <span class="fl">39.1</span>, <span class="fl">36</span>, <span class="fl">15.3</span>, <span class="fl">5.6</span>, <span class="fl">1.1</span>,</span> -<span> <span class="fl">1.6</span>, <span class="fl">0.6</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">2.6</span>, <span class="fl">3.8</span>, <span class="fl">15.3</span>, <span class="fl">37.2</span>, <span class="fl">31.7</span>, <span class="fl">35.6</span>, <span class="fl">14.5</span>,</span> -<span> <span class="fl">0.8</span>, <span class="fl">2.1</span>, <span class="fl">1.9</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span><span class="op">)</span>,</span> -<span> Z3 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="cn">NA</span>, <span class="fl">0.5</span> <span class="op">*</span> <span class="va">LOD</span>, <span class="fl">9.2</span>, <span class="fl">13.1</span>, <span class="fl">22.3</span>, <span class="fl">28.4</span>, <span class="fl">32.5</span>,</span> -<span> <span class="fl">25.2</span>, <span class="fl">17.2</span>, <span class="fl">4.8</span>, <span class="fl">4.5</span>, <span class="fl">2.8</span>, <span class="fl">4.4</span><span class="op">)</span><span class="op">)</span></span> -<span></span> -<span><span class="va">FOCUS_2006_Z_mkin</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">FOCUS_2006_Z</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="parent-and-one-metabolite">Parent and one metabolite<a class="anchor" aria-label="anchor" href="#parent-and-one-metabolite"></a> -</h2> -<p>The next step is to set up the models used for the kinetic analysis. -As the simultaneous fit of parent and the first metabolite is usually -straightforward, Step 1 (SFO for parent only) is skipped here. We start -with the model 2a, with formation and decline of metabolite Z1 and the -pathway from parent directly to sink included (default in mkin).</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.2a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.2a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.2a</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.2a, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span></span> -<span><span class="co">## value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.2a</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_1-1.png" width="700"></p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.2a</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></code></pre></div> -<pre><code><span><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642</span></span> -<span><span class="co">## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600</span></span> -<span><span class="co">## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762</span></span> -<span><span class="co">## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000</span></span> -<span><span class="co">## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</span></span></code></pre> -<p>As obvious from the parameter summary (the component of the summary), -the kinetic rate constant from parent compound Z to sink is very small -and the t-test for this parameter suggests that it is not significantly -different from zero. This suggests, in agreement with the analysis in -the FOCUS kinetics report, to simplify the model by removing the pathway -to sink.</p> -<p>A similar result can be obtained when formation fractions are used in -the model formulation:</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.2a.ff</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.2a.ff</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.2a.ff</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.2a.ff, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span></span> -<span><span class="co">## value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.2a.ff</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_2-1.png" width="700"></p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.2a.ff</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></code></pre></div> -<pre><code><span><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## Z0_0 97.01488 3.301084 29.3888 3.2971e-21 91.66556 102.3642</span></span> -<span><span class="co">## k_Z0 2.23601 0.207078 10.7979 3.3309e-11 1.95303 2.5600</span></span> -<span><span class="co">## k_Z1 0.48212 0.063265 7.6207 2.8154e-08 0.40341 0.5762</span></span> -<span><span class="co">## f_Z0_to_Z1 1.00000 0.094764 10.5525 5.3560e-11 0.00000 1.0000</span></span> -<span><span class="co">## sigma 4.80411 0.635638 7.5579 3.2592e-08 3.52677 6.0815</span></span></code></pre> -<p>Here, the ilr transformed formation fraction fitted in the model -takes a very large value, and the backtransformed formation fraction -from parent Z to Z1 is practically unity. Here, the covariance matrix -used for the calculation of confidence intervals is not returned as the -model is overparameterised.</p> -<p>A simplified model is obtained by removing the pathway to the sink. -</p> -<p>In the following, we use the parameterisation with formation -fractions in order to be able to compare with the results in the FOCUS -guidance, and as it makes it easier to use parameters obtained in a -previous fit when adding a further metabolite.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.3</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span></span> -<span><span class="co">## value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.3</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_3-1.png" width="700"></p> -<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.3</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></code></pre></div> -<pre><code><span><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## Z0_0 97.01488 2.597342 37.352 2.0106e-24 91.67597 102.3538</span></span> -<span><span class="co">## k_Z0 2.23601 0.146904 15.221 9.1477e-15 1.95354 2.5593</span></span> -<span><span class="co">## k_Z1 0.48212 0.041727 11.554 4.8268e-12 0.40355 0.5760</span></span> -<span><span class="co">## sigma 4.80411 0.620208 7.746 1.6110e-08 3.52925 6.0790</span></span></code></pre> -<p>As there is only one transformation product for Z0 and no pathway to -sink, the formation fraction is internally fixed to unity.</p> -</div> -<div class="section level2"> -<h2 id="metabolites-z2-and-z3">Metabolites Z2 and Z3<a class="anchor" aria-label="anchor" href="#metabolites-z2-and-z3"></a> -</h2> -<p>As suggested in the FOCUS report, the pathway to sink was removed for -metabolite Z1 as well in the next step. While this step appears -questionable on the basis of the above results, it is followed here for -the purpose of comparison. Also, in the FOCUS report, it is assumed that -there is additional empirical evidence that Z1 quickly and exclusively -hydrolyses to Z2.</p> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.5, FOCUS_2006_Z_mkin, quiet = TRUE): Observations with</span></span> -<span><span class="co">## value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.5</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_5-1.png" width="700"></p> -<p>Finally, metabolite Z3 is added to the model. We use the optimised -differential equation parameter values from the previous fit in order to -accelerate the optimization.</p> -<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.FOCUS</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>,</span> -<span> Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb30"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.FOCUS</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.FOCUS</span>, <span class="va">FOCUS_2006_Z_mkin</span>,</span> -<span> parms.ini <span class="op">=</span> <span class="va">m.Z.5</span><span class="op">$</span><span class="va">bparms.ode</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, :</span></span> -<span><span class="co">## Observations with value of zero were removed from the data</span></span></code></pre> -<pre><code><span><span class="co">## Warning in mkinfit(Z.FOCUS, FOCUS_2006_Z_mkin, parms.ini = m.Z.5$bparms.ode, : Optimisation did not converge:</span></span> -<span><span class="co">## false convergence (8)</span></span></code></pre> -<div class="sourceCode" id="cb33"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_6-1.png" width="700"></p> -<div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></code></pre></div> -<pre><code><span><span class="co">## Estimate se_notrans t value Pr(>t) Lower Upper</span></span> -<span><span class="co">## Z0_0 96.838822 1.994274 48.5584 4.0280e-42 92.826981 100.850664</span></span> -<span><span class="co">## k_Z0 2.215393 0.118458 18.7019 1.0413e-23 1.989456 2.466989</span></span> -<span><span class="co">## k_Z1 0.478305 0.028258 16.9266 6.2418e-22 0.424708 0.538666</span></span> -<span><span class="co">## k_Z2 0.451627 0.042139 10.7176 1.6314e-14 0.374339 0.544872</span></span> -<span><span class="co">## k_Z3 0.058692 0.015245 3.8499 1.7803e-04 0.034808 0.098965</span></span> -<span><span class="co">## f_Z2_to_Z3 0.471502 0.058351 8.0805 9.6608e-11 0.357769 0.588274</span></span> -<span><span class="co">## sigma 3.984431 0.383402 10.3923 4.5575e-14 3.213126 4.755736</span></span></code></pre> -<div class="sourceCode" id="cb36"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m.Z.FOCUS</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## $ff</span></span> -<span><span class="co">## Z2_Z3 Z2_sink </span></span> -<span><span class="co">## 0.4715 0.5285 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $distimes</span></span> -<span><span class="co">## DT50 DT90</span></span> -<span><span class="co">## Z0 0.31288 1.0394</span></span> -<span><span class="co">## Z1 1.44917 4.8141</span></span> -<span><span class="co">## Z2 1.53478 5.0984</span></span> -<span><span class="co">## Z3 11.80986 39.2315</span></span></code></pre> -<p>This fit corresponds to the final result chosen in Appendix 7 of the -FOCUS report. Confidence intervals returned by mkin are based on -internally transformed parameters, however.</p> -</div> -<div class="section level2"> -<h2 id="using-the-sforb-model">Using the SFORB model<a class="anchor" aria-label="anchor" href="#using-the-sforb-model"></a> -</h2> -<p>As the FOCUS report states, there is a certain tailing of the time -course of metabolite Z3. Also, the time course of the parent compound is -not fitted very well using the SFO model, as residues at a certain low -level remain.</p> -<p>Therefore, an additional model is offered here, using the single -first-order reversible binding (SFORB) model for metabolite Z3. As -expected, the <span class="math inline">\(\chi^2\)</span> error level is -lower for metabolite Z3 using this model and the graphical fit for Z3 is -improved. However, the covariance matrix is not returned.</p> -<div class="sourceCode" id="cb38"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.mkin.1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>,</span> -<span> Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb40"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.mkin.1</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.1</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.mkin.1, FOCUS_2006_Z_mkin, quiet = TRUE): Observations</span></span> -<span><span class="co">## with value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb42"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.1</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_7-1.png" width="700"></p> -<div class="sourceCode" id="cb43"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m.Z.mkin.1</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">$</span><span class="va">cov.unscaled</span></span></code></pre></div> -<pre><code><span><span class="co">## NULL</span></span></code></pre> -<p>Therefore, a further stepwise model building is performed starting -from the stage of parent and two metabolites, starting from the -assumption that the model fit for the parent compound can be improved by -using the SFORB model.</p> -<div class="sourceCode" id="cb45"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.mkin.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb47"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.mkin.3</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.3</span>, <span class="va">FOCUS_2006_Z_mkin</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.mkin.3, FOCUS_2006_Z_mkin, quiet = TRUE): Observations</span></span> -<span><span class="co">## with value of zero were removed from the data</span></span></code></pre> -<div class="sourceCode" id="cb49"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.3</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_9-1.png" width="700"></p> -<p>This results in a much better representation of the behaviour of the -parent compound Z0.</p> -<p>Finally, Z3 is added as well. These models appear overparameterised -(no covariance matrix returned) if the sink for Z1 is left in the -models.</p> -<div class="sourceCode" id="cb50"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.mkin.4</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>,</span> -<span> Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb52"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.mkin.4</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.4</span>, <span class="va">FOCUS_2006_Z_mkin</span>,</span> -<span> parms.ini <span class="op">=</span> <span class="va">m.Z.mkin.3</span><span class="op">$</span><span class="va">bparms.ode</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.mkin.4, FOCUS_2006_Z_mkin, parms.ini =</span></span> -<span><span class="co">## m.Z.mkin.3$bparms.ode, : Observations with value of zero were removed from the</span></span> -<span><span class="co">## data</span></span></code></pre> -<div class="sourceCode" id="cb54"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.4</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_10-1.png" width="700"></p> -<p>The error level of the fit, but especially of metabolite Z3, can be -improved if the SFORB model is chosen for this metabolite, as this model -is capable of representing the tailing of the metabolite decline -phase.</p> -<div class="sourceCode" id="cb55"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">Z.mkin.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>Z0 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"Z1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z2"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> Z2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"Z3"</span><span class="op">)</span>,</span> -<span> Z3 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb57"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.mkin.5</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>,</span> -<span> parms.ini <span class="op">=</span> <span class="va">m.Z.mkin.4</span><span class="op">$</span><span class="va">bparms.ode</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">]</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini =</span></span> -<span><span class="co">## m.Z.mkin.4$bparms.ode[1:4], : Observations with value of zero were removed from</span></span> -<span><span class="co">## the data</span></span></code></pre> -<div class="sourceCode" id="cb59"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.5</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_11-1.png" width="700"></p> -<p>The summary view of the backtransformed parameters shows that we get -no confidence intervals due to overparameterisation. As the optimized is -excessively small, it seems reasonable to fix it to zero.</p> -<div class="sourceCode" id="cb60"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m.Z.mkin.5a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">Z.mkin.5</span>, <span class="va">FOCUS_2006_Z_mkin</span>,</span> -<span> parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="va">m.Z.mkin.5</span><span class="op">$</span><span class="va">bparms.ode</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span><span class="op">]</span>,</span> -<span> k_Z3_bound_free <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> -<span> fixed_parms <span class="op">=</span> <span class="st">"k_Z3_bound_free"</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in mkinfit(Z.mkin.5, FOCUS_2006_Z_mkin, parms.ini =</span></span> -<span><span class="co">## c(m.Z.mkin.5$bparms.ode[1:7], : Observations with value of zero were removed</span></span> -<span><span class="co">## from the data</span></span></code></pre> -<div class="sourceCode" id="cb62"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m.Z.mkin.5a</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_11a-1.png" width="700"></p> -<p>As expected, the residual plots for Z0 and Z3 are more random than in -the case of the all SFO model for which they were shown above. In -conclusion, the model is proposed as the best-fit model for the dataset -from Appendix 7 of the FOCUS report.</p> -<p>A graphical representation of the confidence intervals can finally be -obtained.</p> -<div class="sourceCode" id="cb63"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/mkinparplot.html">mkinparplot</a></span><span class="op">(</span><span class="va">m.Z.mkin.5a</span><span class="op">)</span></span></code></pre></div> -<p><img src="FOCUS_Z_files/figure-html/FOCUS_2006_Z_fits_11b-1.png" width="700"></p> -<p>The endpoints obtained with this model are</p> -<div class="sourceCode" id="cb64"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m.Z.mkin.5a</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## $ff</span></span> -<span><span class="co">## Z0_free Z2_Z3 Z2_sink Z3_free </span></span> -<span><span class="co">## 1.00000 0.53656 0.46344 1.00000 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $SFORB</span></span> -<span><span class="co">## Z0_b1 Z0_b2 Z0_g Z3_b1 Z3_b2 Z3_g </span></span> -<span><span class="co">## 2.4471322 0.0075125 0.9519862 0.0800069 0.0000000 0.9347820 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $distimes</span></span> -<span><span class="co">## DT50 DT90 DT50back DT50_Z0_b1 DT50_Z0_b2 DT50_Z3_b1 DT50_Z3_b2</span></span> -<span><span class="co">## Z0 0.3043 1.1848 0.35666 0.28325 92.266 NA NA</span></span> -<span><span class="co">## Z1 1.5148 5.0320 NA NA NA NA NA</span></span> -<span><span class="co">## Z2 1.6414 5.4526 NA NA NA NA NA</span></span> -<span><span class="co">## Z3 NA NA NA NA NA 8.6636 Inf</span></span></code></pre> -<p>It is clear the degradation rate of Z3 towards the end of the -experiment is very low as DT50_Z3_b2 (the second Eigenvalue of the -system of two differential equations representing the SFORB system for -Z3, corresponding to the slower rate constant of the DFOP model) is -reported to be infinity. However, this appears to be a feature of the -data.</p> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<!-- vim: set foldmethod=syntax: --> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-FOCUSkinetics2014" class="csl-entry"> -FOCUS Work Group on Degradation Kinetics. 2014. <em>Generic Guidance for -Estimating Persistence and Degradation Kinetics from Environmental Fate -Studies on Pesticides in EU Registration</em>. 1.1 ed. <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a>. -</div> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/web_only/FOCUS_Z_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/web_only/FOCUS_Z_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/web_only/FOCUS_Z_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see https://github.com/jgm/pandoc/issues/6352#issuecomment-626106786) --> -// v0.0.1 -// Written by JooYoung Seo (jooyoung@psu.edu) and Atsushi Yasumoto on June 1st, 2020. - -document.addEventListener('DOMContentLoaded', function() { - const codeList = document.getElementsByClassName("sourceCode"); - for (var i = 0; i < codeList.length; i++) { - var linkList = codeList[i].getElementsByTagName('a'); - for (var j = 0; j < linkList.length; j++) { - if (linkList[j].innerHTML === "") { - linkList[j].setAttribute('aria-hidden', 'true'); - } - } - } -}); diff --git a/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.css b/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.css deleted file mode 100644 index 07aee5fc..00000000 --- a/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.css +++ /dev/null @@ -1,4 +0,0 @@ -/* Styles for section anchors */ -a.anchor-section {margin-left: 10px; visibility: hidden; color: inherit;} -a.anchor-section::before {content: '#';} -.hasAnchor:hover a.anchor-section {visibility: visible;} diff --git a/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.js b/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.js deleted file mode 100644 index 570f99a0..00000000 --- a/docs/dev/articles/web_only/FOCUS_Z_files/anchor-sections-1.0/anchor-sections.js +++ /dev/null @@ -1,33 +0,0 @@ -// Anchor sections v1.0 written by Atsushi Yasumoto on Oct 3rd, 2020. -document.addEventListener('DOMContentLoaded', function() { - // Do nothing if AnchorJS is used - if (typeof window.anchors === 'object' && anchors.hasOwnProperty('hasAnchorJSLink')) { - return; - } - - const h = document.querySelectorAll('h1, h2, h3, h4, h5, h6'); - - // Do nothing if sections are already anchored - if (Array.from(h).some(x => x.classList.contains('hasAnchor'))) { - return null; - } - - // Use section id when pandoc runs with --section-divs - const section_id = function(x) { - return ((x.classList.contains('section') || (x.tagName === 'SECTION')) - ? 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<div class="hidden name"><code>NAFTA_examples.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>In this document, the example evaluations provided in Attachment 1 to -the SOP of US EPA for using the NAFTA guidance <span class="citation">(US EPA 2015)</span> are repeated using mkin. The -original evaluations reported in the attachment were performed using -PestDF in version 0.8.4. Note that PestDF 0.8.13 is the version -distributed at the US EPA website today (2019-02-26).</p> -<p>The datasets are now distributed with the mkin package.</p> -</div> -<div class="section level2"> -<h2 id="examples-where-dfop-did-not-converge-with-pestdf-0-8-4">Examples where DFOP did not converge with PestDF 0.8.4<a class="anchor" aria-label="anchor" href="#examples-where-dfop-did-not-converge-with-pestdf-0-8-4"></a> -</h2> -<p>In attachment 1, it is reported that the DFOP model does not converge -for these datasets when PestDF 0.8.4 was used. For all four datasets, -the DFOP model can be fitted with mkin (see below). The negative -half-life given by PestDF 0.8.4 for these fits appears to be the result -of a bug. The results for the other two models (SFO and IORE) are the -same.</p> -<div class="section level3"> -<h3 id="example-on-page-5-upper-panel">Example on page 5, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-5-upper-panel"></a> -</h3> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p5a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p5a-1.png" width="700"></p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p5a</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 465.21753 56.27506 32.06401 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 64.4304</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 95.8401 4.67e-21 92.245 99.4357</span></span> -<span><span class="co">## k_parent 0.0102 3.92e-12 0.009 0.0117</span></span> -<span><span class="co">## sigma 4.8230 3.81e-06 3.214 6.4318</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.01e+02 NA 9.91e+01 1.02e+02</span></span> -<span><span class="co">## k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05</span></span> -<span><span class="co">## N_parent 2.57e+00 NA 2.25e+00 2.89e+00</span></span> -<span><span class="co">## sigma 1.68e+00 NA 1.12e+00 2.24e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.99e+01 1.41e-26 98.8116 101.0810</span></span> -<span><span class="co">## k1 2.67e-02 5.05e-06 0.0243 0.0295</span></span> -<span><span class="co">## k2 2.26e-12 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## g 6.47e-01 3.67e-06 0.6248 0.6677</span></span> -<span><span class="co">## sigma 1.27e+00 8.91e-06 0.8395 1.6929</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 67.7 2.25e+02 6.77e+01</span></span> -<span><span class="co">## IORE 58.2 1.07e+03 3.22e+02</span></span> -<span><span class="co">## DFOP 55.5 5.59e+11 3.07e+11</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 321.51</span></span></code></pre> -</div> -<div class="section level3"> -<h3 id="example-on-page-5-lower-panel">Example on page 5, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-5-lower-panel"></a> -</h3> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p5b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p5b-1.png" width="700"></p> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p5b</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 94.81123 10.10936 7.55871 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 11.77879</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.497 2.32e-24 94.85271 98.14155</span></span> -<span><span class="co">## k_parent 0.008 3.42e-14 0.00737 0.00869</span></span> -<span><span class="co">## sigma 2.295 1.22e-05 1.47976 3.11036</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.85e+01 1.17e-28 9.79e+01 9.92e+01</span></span> -<span><span class="co">## k__iore_parent 1.53e-04 6.50e-03 7.21e-05 3.26e-04</span></span> -<span><span class="co">## N_parent 1.94e+00 5.88e-13 1.76e+00 2.12e+00</span></span> -<span><span class="co">## sigma 7.49e-01 1.63e-05 4.82e-01 1.02e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.84e+01 1.24e-27 97.8078 98.9187</span></span> -<span><span class="co">## k1 1.55e-02 4.10e-04 0.0143 0.0167</span></span> -<span><span class="co">## k2 8.63e-12 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## g 6.89e-01 2.92e-03 0.6626 0.7142</span></span> -<span><span class="co">## sigma 6.48e-01 2.38e-05 0.4147 0.8813</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 86.6 2.88e+02 8.66e+01</span></span> -<span><span class="co">## IORE 85.5 7.17e+02 2.16e+02</span></span> -<span><span class="co">## DFOP 83.6 1.32e+11 8.04e+10</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 215.87</span></span></code></pre> -</div> -<div class="section level3"> -<h3 id="example-on-page-6">Example on page 6<a class="anchor" aria-label="anchor" href="#example-on-page-6"></a> -</h3> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p6</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p6"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p6-1.png" width="700"></p> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p6</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 188.45361 51.00699 42.46931 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 58.39888</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 94.7759 7.29e-24 92.3478 97.2039</span></span> -<span><span class="co">## k_parent 0.0179 8.02e-16 0.0166 0.0194</span></span> -<span><span class="co">## sigma 3.0696 3.81e-06 2.0456 4.0936</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.12446 2.63e-26 95.62461 98.62431</span></span> -<span><span class="co">## k__iore_parent 0.00252 1.95e-03 0.00134 0.00472</span></span> -<span><span class="co">## N_parent 1.49587 4.07e-13 1.33896 1.65279</span></span> -<span><span class="co">## sigma 1.59698 5.05e-06 1.06169 2.13227</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.66e+01 1.57e-25 95.3476 97.8979</span></span> -<span><span class="co">## k1 2.55e-02 7.33e-06 0.0233 0.0278</span></span> -<span><span class="co">## k2 3.22e-11 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## g 8.61e-01 7.55e-06 0.8314 0.8867</span></span> -<span><span class="co">## sigma 1.46e+00 6.93e-06 0.9661 1.9483</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 38.6 1.28e+02 3.86e+01</span></span> -<span><span class="co">## IORE 34.0 1.77e+02 5.32e+01</span></span> -<span><span class="co">## DFOP 34.1 1.01e+10 2.15e+10</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 53.17</span></span></code></pre> -</div> -<div class="section level3"> -<h3 id="example-on-page-7">Example on page 7<a class="anchor" aria-label="anchor" href="#example-on-page-7"></a> -</h3> -<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p7</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p7"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p7-1.png" width="700"></p> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p7</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 3661.661 3195.030 3174.145 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 3334.194</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.41796 4.80e-53 93.32245 99.51347</span></span> -<span><span class="co">## k_parent 0.00735 7.64e-21 0.00641 0.00843</span></span> -<span><span class="co">## sigma 7.94557 1.83e-15 6.46713 9.42401</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.92e+01 NA 9.55e+01 1.03e+02</span></span> -<span><span class="co">## k__iore_parent 1.60e-05 NA 1.45e-07 1.77e-03</span></span> -<span><span class="co">## N_parent 2.45e+00 NA 1.35e+00 3.54e+00</span></span> -<span><span class="co">## sigma 7.42e+00 NA 6.04e+00 8.80e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.89e+01 9.44e-49 95.4640 102.2573</span></span> -<span><span class="co">## k1 1.81e-02 1.75e-01 0.0116 0.0281</span></span> -<span><span class="co">## k2 3.63e-10 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## g 6.06e-01 2.19e-01 0.4826 0.7178</span></span> -<span><span class="co">## sigma 7.40e+00 2.97e-15 6.0201 8.7754</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 94.3 3.13e+02 9.43e+01</span></span> -<span><span class="co">## IORE 96.7 1.51e+03 4.55e+02</span></span> -<span><span class="co">## DFOP 96.4 3.77e+09 1.91e+09</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 454.55</span></span></code></pre> -</div> -</div> -<div class="section level2"> -<h2 id="examples-where-the-representative-half-life-deviates-from-the-observed-dt50">Examples where the representative half-life deviates from the -observed DT50<a class="anchor" aria-label="anchor" href="#examples-where-the-representative-half-life-deviates-from-the-observed-dt50"></a> -</h2> -<div class="section level3"> -<h3 id="example-on-page-8">Example on page 8<a class="anchor" aria-label="anchor" href="#example-on-page-8"></a> -</h3> -<p>For this dataset, the IORE fit does not converge when the default -starting values used by mkin for the IORE model are used. Therefore, a -lower value for the rate constant is used here.</p> -<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p8</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p8"</span><span class="op">]</span><span class="op">]</span>, parms.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k__iore_parent <span class="op">=</span> <span class="fl">1e-3</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p8-1.png" width="700"></p> -<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p8</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 1996.9408 444.9237 547.5616 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 477.4924</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 88.16549 6.53e-29 83.37344 92.95754</span></span> -<span><span class="co">## k_parent 0.00803 1.67e-13 0.00674 0.00957</span></span> -<span><span class="co">## sigma 7.44786 4.17e-10 5.66209 9.23363</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.77e+01 7.03e-35 9.44e+01 1.01e+02</span></span> -<span><span class="co">## k__iore_parent 6.14e-05 3.20e-02 2.12e-05 1.78e-04</span></span> -<span><span class="co">## N_parent 2.27e+00 4.23e-18 2.00e+00 2.54e+00</span></span> -<span><span class="co">## sigma 3.52e+00 5.36e-10 2.67e+00 4.36e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 95.70619 8.99e-32 91.87941 99.53298</span></span> -<span><span class="co">## k1 0.02500 5.25e-04 0.01422 0.04394</span></span> -<span><span class="co">## k2 0.00273 6.84e-03 0.00125 0.00597</span></span> -<span><span class="co">## g 0.58835 2.84e-06 0.36595 0.77970</span></span> -<span><span class="co">## sigma 3.90001 6.94e-10 2.96260 4.83741</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 86.3 287 86.3</span></span> -<span><span class="co">## IORE 53.4 668 201.0</span></span> -<span><span class="co">## DFOP 55.6 517 253.0</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 201.03</span></span></code></pre> -</div> -</div> -<div class="section level2"> -<h2 id="examples-where-sfo-was-not-selected-for-an-abiotic-study">Examples where SFO was not selected for an abiotic study<a class="anchor" aria-label="anchor" href="#examples-where-sfo-was-not-selected-for-an-abiotic-study"></a> -</h2> -<div class="section level3"> -<h3 id="example-on-page-9-upper-panel">Example on page 9, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-9-upper-panel"></a> -</h3> -<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p9a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p9a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb34"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p9a-1.png" width="700"></p> -<div class="sourceCode" id="cb35"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p9a</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 839.35238 88.57064 9.93363 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 105.5678</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 88.1933 3.06e-12 79.9447 96.4419</span></span> -<span><span class="co">## k_parent 0.0409 2.07e-07 0.0324 0.0516</span></span> -<span><span class="co">## sigma 7.2429 3.92e-05 4.4768 10.0090</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.89e+01 1.12e-16 9.54e+01 1.02e+02</span></span> -<span><span class="co">## k__iore_parent 1.93e-05 1.13e-01 3.49e-06 1.06e-04</span></span> -<span><span class="co">## N_parent 2.91e+00 1.45e-09 2.50e+00 3.32e+00</span></span> -<span><span class="co">## sigma 2.35e+00 5.31e-05 1.45e+00 3.26e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 9.85e+01 2.54e-20 97.390 99.672</span></span> -<span><span class="co">## k1 1.38e-01 3.52e-05 0.131 0.146</span></span> -<span><span class="co">## k2 9.02e-13 5.00e-01 0.000 Inf</span></span> -<span><span class="co">## g 6.52e-01 8.13e-06 0.642 0.661</span></span> -<span><span class="co">## sigma 7.88e-01 6.13e-02 0.481 1.095</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 16.9 5.63e+01 1.69e+01</span></span> -<span><span class="co">## IORE 11.6 3.37e+02 1.01e+02</span></span> -<span><span class="co">## DFOP 10.5 1.38e+12 7.69e+11</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 101.43</span></span></code></pre> -<p>In this example, the residuals of the SFO indicate a lack of fit of -this model, so even if it was an abiotic experiment, the data do not -suggest a simple exponential decline.</p> -</div> -<div class="section level3"> -<h3 id="example-on-page-9-lower-panel">Example on page 9, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-9-lower-panel"></a> -</h3> -<div class="sourceCode" id="cb37"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p9b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p9b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb44"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p9b-1.png" width="700"></p> -<div class="sourceCode" id="cb45"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p9b</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 35.64867 23.22334 35.64867 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 28.54188</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 94.7123 2.15e-19 93.178 96.2464</span></span> -<span><span class="co">## k_parent 0.0389 4.47e-14 0.037 0.0408</span></span> -<span><span class="co">## sigma 1.5957 1.28e-04 0.932 2.2595</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 93.863 2.32e-18 92.4565 95.269</span></span> -<span><span class="co">## k__iore_parent 0.127 1.85e-02 0.0504 0.321</span></span> -<span><span class="co">## N_parent 0.711 1.88e-05 0.4843 0.937</span></span> -<span><span class="co">## sigma 1.288 1.76e-04 0.7456 1.830</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 94.7123 1.61e-16 93.1355 96.2891</span></span> -<span><span class="co">## k1 0.0389 1.08e-04 0.0266 0.0569</span></span> -<span><span class="co">## k2 0.0389 2.23e-04 0.0255 0.0592</span></span> -<span><span class="co">## g 0.5256 NaN NA NA</span></span> -<span><span class="co">## sigma 1.5957 2.50e-04 0.9135 2.2779</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 17.8 59.2 17.8</span></span> -<span><span class="co">## IORE 18.4 49.2 14.8</span></span> -<span><span class="co">## DFOP 17.8 59.2 17.8</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 14.8</span></span></code></pre> -<p>Here, mkin gives a longer slow DT50 for the DFOP model (17.8 days) -than PestDF (13.5 days). Presumably, this is related to the fact that -PestDF gives a negative value for the proportion of the fast degradation -which should be between 0 and 1, inclusive. This parameter is called f -in PestDF and g in mkin. In mkin, it is restricted to the interval from -0 to 1.</p> -</div> -<div class="section level3"> -<h3 id="example-on-page-10">Example on page 10<a class="anchor" aria-label="anchor" href="#example-on-page-10"></a> -</h3> -<div class="sourceCode" id="cb47"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p10</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p10"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb53"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p10-1.png" width="700"></p> -<div class="sourceCode" id="cb54"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p10</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 899.4089 336.4348 899.4089 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 413.4841</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 101.7315 6.42e-11 91.9259 111.5371</span></span> -<span><span class="co">## k_parent 0.0495 1.70e-07 0.0404 0.0607</span></span> -<span><span class="co">## sigma 8.0152 1.28e-04 4.6813 11.3491</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.86 3.32e-12 90.848 102.863</span></span> -<span><span class="co">## k__iore_parent 2.96 7.91e-02 0.687 12.761</span></span> -<span><span class="co">## N_parent 0.00 5.00e-01 -0.372 0.372</span></span> -<span><span class="co">## sigma 4.90 1.77e-04 2.837 6.968</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 101.7315 1.41e-09 91.6534 111.8097</span></span> -<span><span class="co">## k1 0.0495 6.58e-03 0.0303 0.0809</span></span> -<span><span class="co">## k2 0.0495 2.60e-03 0.0410 0.0598</span></span> -<span><span class="co">## g 0.4487 5.00e-01 NA NA</span></span> -<span><span class="co">## sigma 8.0152 2.50e-04 4.5886 11.4418</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 14.0 46.5 14.00</span></span> -<span><span class="co">## IORE 16.4 29.4 8.86</span></span> -<span><span class="co">## DFOP 14.0 46.5 14.00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 8.86</span></span></code></pre> -<p>Here, a value below N is given for the IORE model, because the data -suggests a faster decline towards the end of the experiment, which -appears physically rather unlikely in the case of a photolysis study. It -seems PestDF does not constrain N to values above zero, thus the slight -difference in IORE model parameters between PestDF and mkin.</p> -</div> -</div> -<div class="section level2"> -<h2 id="the-dt50-was-not-observed-during-the-study">The DT50 was not observed during the study<a class="anchor" aria-label="anchor" href="#the-dt50-was-not-observed-during-the-study"></a> -</h2> -<div class="section level3"> -<h3 id="example-on-page-11">Example on page 11<a class="anchor" aria-label="anchor" href="#example-on-page-11"></a> -</h3> -<div class="sourceCode" id="cb56"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p11</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p11"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb59"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p11-1.png" width="700"></p> -<div class="sourceCode" id="cb60"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p11</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 579.6805 204.7932 144.7783 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 251.6944</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.15820 4.83e-13 90.24934 1.02e+02</span></span> -<span><span class="co">## k_parent 0.00321 4.71e-05 0.00222 4.64e-03</span></span> -<span><span class="co">## sigma 6.43473 1.28e-04 3.75822 9.11e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.05e+02 NA 9.90e+01 1.10e+02</span></span> -<span><span class="co">## k__iore_parent 3.11e-17 NA 1.35e-20 7.18e-14</span></span> -<span><span class="co">## N_parent 8.36e+00 NA 6.62e+00 1.01e+01</span></span> -<span><span class="co">## sigma 3.82e+00 NA 2.21e+00 5.44e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.05e+02 9.47e-13 99.9990 109.1224</span></span> -<span><span class="co">## k1 4.41e-02 5.95e-03 0.0296 0.0658</span></span> -<span><span class="co">## k2 9.94e-13 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## g 3.22e-01 1.45e-03 0.2814 0.3650</span></span> -<span><span class="co">## sigma 3.22e+00 3.52e-04 1.8410 4.5906</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 2.16e+02 7.18e+02 2.16e+02</span></span> -<span><span class="co">## IORE 9.73e+02 1.37e+08 4.11e+07</span></span> -<span><span class="co">## DFOP 3.07e+11 1.93e+12 6.98e+11</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 41148170</span></span></code></pre> -<p>In this case, the DFOP fit reported for PestDF resulted in a negative -value for the slower rate constant, which is not possible in mkin. The -other results are in agreement.</p> -</div> -</div> -<div class="section level2"> -<h2 id="n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant">N is less than 1 and the DFOP rate constants are like the SFO rate -constant<a class="anchor" aria-label="anchor" href="#n-is-less-than-1-and-the-dfop-rate-constants-are-like-the-sfo-rate-constant"></a> -</h2> -<p>In the following three examples, the same results are obtained with -mkin as reported for PestDF. As in the case on page 10, the N values -below 1 are deemed unrealistic and appear to be the result of an -overparameterisation.</p> -<div class="section level3"> -<h3 id="example-on-page-12-upper-panel">Example on page 12, upper panel<a class="anchor" aria-label="anchor" href="#example-on-page-12-upper-panel"></a> -</h3> -<div class="sourceCode" id="cb62"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p12a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p12a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in summary.mkinfit(x): Could not calculate correlation; no covariance</span></span> -<span><span class="co">## matrix</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb70"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p12a-1.png" width="700"></p> -<div class="sourceCode" id="cb71"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p12a</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 695.4440 220.0685 695.4440 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 270.4679</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 100.521 8.75e-12 92.461 108.581</span></span> -<span><span class="co">## k_parent 0.124 3.61e-08 0.104 0.148</span></span> -<span><span class="co">## sigma 7.048 1.28e-04 4.116 9.980</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 96.823 NA NA NA</span></span> -<span><span class="co">## k__iore_parent 2.436 NA NA NA</span></span> -<span><span class="co">## N_parent 0.263 NA NA NA</span></span> -<span><span class="co">## sigma 3.965 NA NA NA</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 100.521 2.74e-10 92.2366 108.805</span></span> -<span><span class="co">## k1 0.124 2.53e-05 0.0908 0.170</span></span> -<span><span class="co">## k2 0.124 2.52e-02 0.0456 0.339</span></span> -<span><span class="co">## g 0.793 NaN NA NA</span></span> -<span><span class="co">## sigma 7.048 2.50e-04 4.0349 10.061</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 5.58 18.5 5.58</span></span> -<span><span class="co">## IORE 6.49 13.2 3.99</span></span> -<span><span class="co">## DFOP 5.58 18.5 5.58</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 3.99</span></span></code></pre> -</div> -<div class="section level3"> -<h3 id="example-on-page-12-lower-panel">Example on page 12, lower panel<a class="anchor" aria-label="anchor" href="#example-on-page-12-lower-panel"></a> -</h3> -<div class="sourceCode" id="cb73"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p12b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p12b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in qt(alpha/2, rdf): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in qt(1 - alpha/2, rdf): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar_notrans)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in pt(abs(tval), rdf, lower.tail = FALSE): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb80"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p12b-1.png" width="700"></p> -<div class="sourceCode" id="cb81"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p12b</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 58.90242 19.06353 58.90242 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 51.51756</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.6840 0.00039 85.9388 109.4292</span></span> -<span><span class="co">## k_parent 0.0589 0.00261 0.0431 0.0805</span></span> -<span><span class="co">## sigma 3.4323 0.04356 -1.2377 8.1023</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 95.523 0.0055 74.539157 116.51</span></span> -<span><span class="co">## k__iore_parent 0.333 0.1433 0.000717 154.57</span></span> -<span><span class="co">## N_parent 0.568 0.0677 -0.989464 2.13</span></span> -<span><span class="co">## sigma 1.953 0.0975 -5.893100 9.80</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.6840 NaN NaN NaN</span></span> -<span><span class="co">## k1 0.0589 NaN NA NA</span></span> -<span><span class="co">## k2 0.0589 NaN NA NA</span></span> -<span><span class="co">## g 0.6473 NaN NA NA</span></span> -<span><span class="co">## sigma 3.4323 NaN NaN NaN</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 11.8 39.1 11.80</span></span> -<span><span class="co">## IORE 12.9 31.4 9.46</span></span> -<span><span class="co">## DFOP 11.8 39.1 11.80</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 9.46</span></span></code></pre> -</div> -<div class="section level3"> -<h3 id="example-on-page-13">Example on page 13<a class="anchor" aria-label="anchor" href="#example-on-page-13"></a> -</h3> -<div class="sourceCode" id="cb83"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p13</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p13"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb86"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p13-1.png" width="700"></p> -<div class="sourceCode" id="cb87"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p13</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 174.5971 142.3951 174.5971 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 172.131</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 92.73500 5.99e-17 89.61936 95.85065</span></span> -<span><span class="co">## k_parent 0.00258 2.42e-09 0.00223 0.00299</span></span> -<span><span class="co">## sigma 3.41172 7.07e-05 2.05455 4.76888</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 91.6016 6.34e-16 88.53086 94.672</span></span> -<span><span class="co">## k__iore_parent 0.0396 2.36e-01 0.00207 0.759</span></span> -<span><span class="co">## N_parent 0.3541 1.46e-01 -0.35153 1.060</span></span> -<span><span class="co">## sigma 3.0811 9.64e-05 1.84296 4.319</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 92.73500 NA 8.95e+01 95.92118</span></span> -<span><span class="co">## k1 0.00258 NA 4.14e-04 0.01611</span></span> -<span><span class="co">## k2 0.00258 NA 1.74e-03 0.00383</span></span> -<span><span class="co">## g 0.16452 NA 0.00e+00 1.00000</span></span> -<span><span class="co">## sigma 3.41172 NA 2.02e+00 4.79960</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 269 892 269</span></span> -<span><span class="co">## IORE 261 560 169</span></span> -<span><span class="co">## DFOP 269 892 269</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 168.51</span></span></code></pre> -</div> -</div> -<div class="section level2"> -<h2 id="dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf">DT50 not observed in the study and DFOP problems in PestDF<a class="anchor" aria-label="anchor" href="#dt50-not-observed-in-the-study-and-dfop-problems-in-pestdf"></a> -</h2> -<div class="sourceCode" id="cb89"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p14</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p14"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb95"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p14-1.png" width="700"></p> -<div class="sourceCode" id="cb96"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p14</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 48.43249 28.67746 27.26248 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 32.83337</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 99.47124 2.06e-30 98.42254 1.01e+02</span></span> -<span><span class="co">## k_parent 0.00279 3.75e-15 0.00256 3.04e-03</span></span> -<span><span class="co">## sigma 1.55616 3.81e-06 1.03704 2.08e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.00e+02 NA NaN NaN</span></span> -<span><span class="co">## k__iore_parent 9.44e-08 NA NaN NaN</span></span> -<span><span class="co">## N_parent 3.31e+00 NA NaN NaN</span></span> -<span><span class="co">## sigma 1.20e+00 NA 0.796 1.6</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.00e+02 2.96e-28 99.40280 101.2768</span></span> -<span><span class="co">## k1 9.53e-03 1.20e-01 0.00638 0.0143</span></span> -<span><span class="co">## k2 6.08e-12 5.00e-01 0.00000 Inf</span></span> -<span><span class="co">## g 3.98e-01 2.19e-01 0.30481 0.4998</span></span> -<span><span class="co">## sigma 1.17e+00 7.68e-06 0.77406 1.5610</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 2.48e+02 8.25e+02 2.48e+02</span></span> -<span><span class="co">## IORE 4.34e+02 2.22e+04 6.70e+03</span></span> -<span><span class="co">## DFOP 3.05e+10 2.95e+11 1.14e+11</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 6697.44</span></span></code></pre> -<p>The slower rate constant reported by PestDF is negative, which is not -physically realistic, and not possible in mkin. The other fits give the -same results in mkin and PestDF.</p> -</div> -<div class="section level2"> -<h2 id="n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero">N is less than 1 and DFOP fraction parameter is below zero<a class="anchor" aria-label="anchor" href="#n-is-less-than-1-and-dfop-fraction-parameter-is-below-zero"></a> -</h2> -<div class="sourceCode" id="cb98"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p15a</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p15a"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb101"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p15a-1.png" width="700"></p> -<div class="sourceCode" id="cb102"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p15a</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 245.5248 135.0132 245.5248 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 165.9335</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.96751 2.00e-15 94.32049 101.615</span></span> -<span><span class="co">## k_parent 0.00952 4.93e-09 0.00824 0.011</span></span> -<span><span class="co">## sigma 4.18778 1.28e-04 2.44588 5.930</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 95.874 2.94e-15 92.937 98.811</span></span> -<span><span class="co">## k__iore_parent 0.629 2.11e-01 0.044 8.982</span></span> -<span><span class="co">## N_parent 0.000 5.00e-01 -0.642 0.642</span></span> -<span><span class="co">## sigma 3.105 1.78e-04 1.795 4.416</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 97.96751 2.85e-13 94.21913 101.7159</span></span> -<span><span class="co">## k1 0.00952 6.28e-02 0.00250 0.0363</span></span> -<span><span class="co">## k2 0.00952 1.27e-04 0.00646 0.0140</span></span> -<span><span class="co">## g 0.21241 5.00e-01 0.00000 1.0000</span></span> -<span><span class="co">## sigma 4.18778 2.50e-04 2.39747 5.9781</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 72.8 242 72.8</span></span> -<span><span class="co">## IORE 76.3 137 41.3</span></span> -<span><span class="co">## DFOP 72.8 242 72.8</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 41.33</span></span></code></pre> -<div class="sourceCode" id="cb104"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p15b</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p15b"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Warning in sqrt(diag(covar)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in sqrt(1/diag(V)): NaNs produced</span></span></code></pre> -<pre><code><span><span class="co">## Warning in cov2cor(ans$covar): diag(.) had 0 or NA entries; non-finite result</span></span> -<span><span class="co">## is doubtful</span></span></code></pre> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The half-life obtained from the IORE model may be used</span></span></code></pre> -<div class="sourceCode" id="cb110"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p15b-1.png" width="700"></p> -<div class="sourceCode" id="cb111"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p15b</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 106.91629 68.55574 106.91629 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 84.25618</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.01e+02 3.06e-17 98.31594 1.03e+02</span></span> -<span><span class="co">## k_parent 4.86e-03 2.48e-10 0.00435 5.42e-03</span></span> -<span><span class="co">## sigma 2.76e+00 1.28e-04 1.61402 3.91e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 99.83 1.81e-16 97.51349 102.14</span></span> -<span><span class="co">## k__iore_parent 0.38 3.22e-01 0.00352 41.05</span></span> -<span><span class="co">## N_parent 0.00 5.00e-01 -1.07696 1.08</span></span> -<span><span class="co">## sigma 2.21 2.57e-04 1.23245 3.19</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 1.01e+02 NA 9.82e+01 1.04e+02</span></span> -<span><span class="co">## k1 4.86e-03 NA 8.63e-04 2.73e-02</span></span> -<span><span class="co">## k2 4.86e-03 NA 3.21e-03 7.35e-03</span></span> -<span><span class="co">## g 1.88e-01 NA NA NA</span></span> -<span><span class="co">## sigma 2.76e+00 NA 1.58e+00 3.94e+00</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 143 474 143.0</span></span> -<span><span class="co">## IORE 131 236 71.2</span></span> -<span><span class="co">## DFOP 143 474 143.0</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 71.18</span></span></code></pre> -<p>In mkin, only the IORE fit is affected (deemed unrealistic), as the -fraction parameter of the DFOP model is restricted to the interval -between 0 and 1 in mkin. The SFO fits give the same results for both -mkin and PestDF.</p> -</div> -<div class="section level2"> -<h2 id="the-dfop-fraction-parameter-is-greater-than-1">The DFOP fraction parameter is greater than 1<a class="anchor" aria-label="anchor" href="#the-dfop-fraction-parameter-is-greater-than-1"></a> -</h2> -<div class="sourceCode" id="cb113"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">p16</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p16"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span></span></code></pre> -<pre><code><span><span class="co">## The representative half-life of the IORE model is longer than the one corresponding</span></span></code></pre> -<pre><code><span><span class="co">## to the terminal degradation rate found with the DFOP model.</span></span></code></pre> -<pre><code><span><span class="co">## The representative half-life obtained from the DFOP model may be used</span></span></code></pre> -<div class="sourceCode" id="cb118"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></span></code></pre></div> -<p><img src="NAFTA_examples_files/figure-html/p16-1.png" width="700"></p> -<div class="sourceCode" id="cb119"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">p16</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Sums of squares:</span></span> -<span><span class="co">## SFO IORE DFOP </span></span> -<span><span class="co">## 3831.804 2062.008 1550.980 </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Critical sum of squares for checking the SFO model:</span></span> -<span><span class="co">## [1] 2247.348</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Parameters:</span></span> -<span><span class="co">## $SFO</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 71.953 2.33e-13 60.509 83.40</span></span> -<span><span class="co">## k_parent 0.159 4.86e-05 0.102 0.25</span></span> -<span><span class="co">## sigma 11.302 1.25e-08 8.308 14.30</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $IORE</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 8.74e+01 2.48e-16 7.72e+01 97.52972</span></span> -<span><span class="co">## k__iore_parent 4.55e-04 2.16e-01 3.48e-05 0.00595</span></span> -<span><span class="co">## N_parent 2.70e+00 1.21e-08 1.99e+00 3.40046</span></span> -<span><span class="co">## sigma 8.29e+00 1.61e-08 6.09e+00 10.49062</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## $DFOP</span></span> -<span><span class="co">## Estimate Pr(>t) Lower Upper</span></span> -<span><span class="co">## parent_0 88.5333 7.40e-18 79.9836 97.083</span></span> -<span><span class="co">## k1 18.8461 5.00e-01 0.0000 Inf</span></span> -<span><span class="co">## k2 0.0776 1.41e-05 0.0518 0.116</span></span> -<span><span class="co">## g 0.4733 1.41e-09 0.3674 0.582</span></span> -<span><span class="co">## sigma 7.1902 2.11e-08 5.2785 9.102</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## </span></span> -<span><span class="co">## DTx values:</span></span> -<span><span class="co">## DT50 DT90 DT50_rep</span></span> -<span><span class="co">## SFO 4.35 14.4 4.35</span></span> -<span><span class="co">## IORE 1.48 32.1 9.67</span></span> -<span><span class="co">## DFOP 0.67 21.4 8.93</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## Representative half-life:</span></span> -<span><span class="co">## [1] 8.93</span></span></code></pre> -<p>In PestDF, the DFOP fit seems to have stuck in a local minimum, as -mkin finds a solution with a much lower <span class="math inline">\(\chi^2\)</span> error level. As the half-life from -the slower rate constant of the DFOP model is larger than the IORE -derived half-life, the NAFTA recommendation obtained with mkin is to use -the DFOP representative half-life of 8.9 days.</p> -</div> -<div class="section level2"> -<h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#conclusions"></a> -</h2> -<p>The results obtained with mkin deviate from the results obtained with -PestDF either in cases where one of the interpretive rules would apply, -i.e. the IORE parameter N is less than one or the DFOP k values obtained -with PestDF are equal to the SFO k values, or in cases where the DFOP -model did not converge, which often lead to negative rate constants -returned by PestDF.</p> -<p>Therefore, mkin appears to suitable for kinetic evaluations according -to the NAFTA guidance.</p> -</div> -<div class="section level2"> -<h2 class="unnumbered" id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-usepa2015" class="csl-entry"> -US EPA. 2015. <span>“Standard Operating Procedure for Using the NAFTA -Guidance to Calculate Representative Half-Life Values and Characterizing -Pesticide Degradation.”</span> <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a>. -</div> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> 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</li> - <li> - <a href="../../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Benchmark timings for mkin</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 17 February 2023 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/benchmarks.rmd" class="external-link"><code>vignettes/web_only/benchmarks.rmd</code></a></small> - <div class="hidden name"><code>benchmarks.rmd</code></div> - - </div> - - - -<p>Each system is characterized by the operating system type, the CPU -type, the mkin version, and, as in June 2022 the current R version lead -to worse performance, the R version. A compiler was available, so if no -analytical solution was available, compiled ODE models are used.</p> -<p>Every fit is only performed once, so the accuracy of the benchmarks -is limited.</p> -<p>The following wrapper function for <code>mmkin</code> is used because -the way the error model is specified was changed in mkin version -0.9.49.1.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/utils/packageDescription.html" class="external-link">packageVersion</a></span><span class="op">(</span><span class="st">"mkin"</span><span class="op">)</span> <span class="op">></span> <span class="st">"0.9.48.1"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">mmkin_bench</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, <span class="va">error_model</span> <span class="op">=</span> <span class="st">"const"</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, error_model <span class="op">=</span> <span class="va">error_model</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span> <span class="op">}</span></span> -<span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">mmkin_bench</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, <span class="va">error_model</span> <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, reweight.method <span class="op">=</span> <span class="va">error_model</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span> <span class="op">}</span></span> -<span><span class="op">}</span></span></code></pre></div> -<div class="section level2"> -<h2 id="test-cases">Test cases<a class="anchor" aria-label="anchor" href="#test-cases"></a> -</h2> -<p>Parent only:</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">FOCUS_C</span> <span class="op"><-</span> <span class="va">FOCUS_2006_C</span></span> -<span><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span> -<span><span class="va">parent_datasets</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_C</span>, <span class="va">FOCUS_D</span><span class="op">)</span></span> -<span></span> -<span></span> -<span><span class="va">t1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">parent_datasets</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -<p>One metabolite:</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> -<span> m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> -<span> m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>, <span class="co"># erroneously used FOMC twice, not fixed for consistency</span></span> -<span> m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="va">t3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t4</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t5</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOMC_SFO</span>, <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">FOCUS_D</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -<p>Two metabolites, synthetic data:</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span> -<span> M1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> -<span> M2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M2 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="va">SFO_lin_a</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> -<span></span> -<span><span class="va">DFOP_par_c</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> -<span></span> -<span><span class="va">t6</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t7</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span></span> -<span><span class="va">t8</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t9</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span></span> -<span><span class="va">t10</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">SFO_lin_a</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t11</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="fu">mmkin_bench</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DFOP_par_c</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="results">Results<a class="anchor" aria-label="anchor" href="#results"></a> -</h2> -<p>Benchmarks for all available error models are shown. They are -intended for improving mkin, not for comparing CPUs or operating -systems. All trademarks belong to their respective owners.</p> -<div class="section level3"> -<h3 id="parent-only">Parent only<a class="anchor" aria-label="anchor" href="#parent-only"></a> -</h3> -<p>Constant variance (t1) and two-component error model (t2) for four -models fitted to two datasets, i.e. eight fits for each test.</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">OS</th> -<th align="left">CPU</th> -<th align="left">R</th> -<th align="left">mkin</th> -<th align="right">t1</th> -<th align="right">t2</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.48.1</td> -<td align="right">3.610</td> -<td align="right">11.019</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.1</td> -<td align="right">8.184</td> -<td align="right">22.889</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.2</td> -<td align="right">7.064</td> -<td align="right">12.558</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.3</td> -<td align="right">7.296</td> -<td align="right">21.239</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.4</td> -<td align="right">5.936</td> -<td align="right">20.545</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.2</td> -<td align="right">1.714</td> -<td align="right">3.971</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.3</td> -<td align="right">1.752</td> -<td align="right">4.156</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.4</td> -<td align="right">1.786</td> -<td align="right">3.729</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.3</td> -<td align="right">1.881</td> -<td align="right">3.504</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.4</td> -<td align="right">1.867</td> -<td align="right">3.450</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">1.791</td> -<td align="right">3.289</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">1.842</td> -<td align="right">3.453</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">1.959</td> -<td align="right">4.116</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">1.877</td> -<td align="right">3.906</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">1.644</td> -<td align="right">3.172</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">1.770</td> -<td align="right">3.377</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.2</td> -<td align="right">1.957</td> -<td align="right">3.633</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">2.140</td> -<td align="right">3.774</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">2.187</td> -<td align="right">3.851</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">1.288</td> -<td align="right">1.794</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">1.276</td> -<td align="right">1.804</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.3</td> -<td align="right">1.370</td> -<td align="right">1.883</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.3</td> -<td align="left">1.2.3</td> -<td align="right">1.404</td> -<td align="right">1.933</td> -</tr> -</tbody> -</table> -</div> -<div class="section level3"> -<h3 id="one-metabolite">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite"></a> -</h3> -<p>Constant variance (t3), two-component error model (t4), and variance -by variable (t5) for three models fitted to one dataset, i.e. three fits -for each test.</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">OS</th> -<th align="left">CPU</th> -<th align="left">R</th> -<th align="left">mkin</th> -<th align="right">t3</th> -<th align="right">t4</th> -<th align="right">t5</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.48.1</td> -<td align="right">3.764</td> -<td align="right">14.347</td> -<td align="right">9.495</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.1</td> -<td align="right">4.649</td> -<td align="right">13.789</td> -<td align="right">6.395</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.2</td> -<td align="right">4.786</td> -<td align="right">8.461</td> -<td align="right">5.675</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.3</td> -<td align="right">4.510</td> -<td align="right">13.805</td> -<td align="right">7.386</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.4</td> -<td align="right">4.446</td> -<td align="right">15.335</td> -<td align="right">6.002</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.2</td> -<td align="right">1.402</td> -<td align="right">6.174</td> -<td align="right">2.764</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.3</td> -<td align="right">1.430</td> -<td align="right">6.615</td> -<td align="right">2.878</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.4</td> -<td align="right">1.397</td> -<td align="right">7.251</td> -<td align="right">2.810</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.3</td> -<td align="right">1.430</td> -<td align="right">6.344</td> -<td align="right">2.798</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.4</td> -<td align="right">1.415</td> -<td align="right">6.364</td> -<td align="right">2.820</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">1.310</td> -<td align="right">6.279</td> -<td align="right">2.681</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">3.802</td> -<td align="right">21.247</td> -<td align="right">8.461</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">3.334</td> -<td align="right">19.521</td> -<td align="right">7.565</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">1.578</td> -<td align="right">8.058</td> -<td align="right">3.339</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">1.230</td> -<td align="right">5.839</td> -<td align="right">2.444</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">1.308</td> -<td align="right">5.758</td> -<td align="right">2.558</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.2</td> -<td align="right">1.503</td> -<td align="right">6.147</td> -<td align="right">2.803</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">1.554</td> -<td align="right">6.193</td> -<td align="right">2.843</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">1.585</td> -<td align="right">6.335</td> -<td align="right">3.003</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">0.792</td> -<td align="right">2.378</td> -<td align="right">1.245</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">0.784</td> -<td align="right">2.355</td> -<td align="right">1.233</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.3</td> -<td align="right">0.770</td> -<td align="right">2.011</td> -<td align="right">1.123</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.3</td> -<td align="left">1.2.3</td> -<td align="right">0.797</td> -<td align="right">2.124</td> -<td align="right">1.182</td> -</tr> -</tbody> -</table> -</div> -<div class="section level3"> -<h3 id="two-metabolites">Two metabolites<a class="anchor" aria-label="anchor" href="#two-metabolites"></a> -</h3> -<p>Constant variance (t6 and t7), two-component error model (t8 and t9), -and variance by variable (t10 and t11) for one model fitted to one -dataset, i.e. one fit for each test.</p> -<table class="table"> -<colgroup> -<col width="8%"> -<col width="19%"> -<col width="8%"> -<col width="12%"> -<col width="8%"> -<col width="8%"> -<col width="8%"> -<col width="9%"> -<col width="8%"> -<col width="9%"> -</colgroup> -<thead><tr class="header"> -<th align="left">OS</th> -<th align="left">CPU</th> -<th align="left">R</th> -<th align="left">mkin</th> -<th align="right">t6</th> -<th align="right">t7</th> -<th align="right">t8</th> -<th align="right">t9</th> -<th align="right">t10</th> -<th align="right">t11</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.48.1</td> -<td align="right">2.623</td> -<td align="right">4.587</td> -<td align="right">7.525</td> -<td align="right">16.621</td> -<td align="right">8.576</td> -<td align="right">31.267</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.1</td> -<td align="right">2.542</td> -<td align="right">4.128</td> -<td align="right">4.632</td> -<td align="right">8.171</td> -<td align="right">3.676</td> -<td align="right">5.636</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.2</td> -<td align="right">2.723</td> -<td align="right">4.478</td> -<td align="right">4.862</td> -<td align="right">7.618</td> -<td align="right">3.579</td> -<td align="right">5.574</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.3</td> -<td align="right">2.643</td> -<td align="right">4.374</td> -<td align="right">7.020</td> -<td align="right">11.124</td> -<td align="right">5.388</td> -<td align="right">7.365</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.49.4</td> -<td align="right">2.635</td> -<td align="right">4.259</td> -<td align="right">4.737</td> -<td align="right">7.763</td> -<td align="right">3.427</td> -<td align="right">5.626</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.2</td> -<td align="right">0.777</td> -<td align="right">1.236</td> -<td align="right">1.332</td> -<td align="right">2.872</td> -<td align="right">2.069</td> -<td align="right">2.987</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.3</td> -<td align="right">0.858</td> -<td align="right">1.264</td> -<td align="right">1.333</td> -<td align="right">2.984</td> -<td align="right">2.113</td> -<td align="right">3.073</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">0.9.50.4</td> -<td align="right">0.783</td> -<td align="right">1.282</td> -<td align="right">1.486</td> -<td align="right">3.815</td> -<td align="right">1.958</td> -<td align="right">3.105</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.3</td> -<td align="right">0.763</td> -<td align="right">1.244</td> -<td align="right">1.457</td> -<td align="right">3.054</td> -<td align="right">1.923</td> -<td align="right">2.839</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">NA</td> -<td align="left">1.0.4</td> -<td align="right">0.785</td> -<td align="right">1.252</td> -<td align="right">1.466</td> -<td align="right">3.091</td> -<td align="right">1.936</td> -<td align="right">2.826</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">0.744</td> -<td align="right">1.227</td> -<td align="right">1.288</td> -<td align="right">3.553</td> -<td align="right">1.895</td> -<td align="right">2.738</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">3.018</td> -<td align="right">4.165</td> -<td align="right">5.036</td> -<td align="right">10.844</td> -<td align="right">6.623</td> -<td align="right">9.722</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.0</td> -<td align="right">2.522</td> -<td align="right">3.792</td> -<td align="right">4.143</td> -<td align="right">11.268</td> -<td align="right">5.935</td> -<td align="right">8.728</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.1.3</td> -<td align="left">1.1.0</td> -<td align="right">0.907</td> -<td align="right">1.535</td> -<td align="right">1.589</td> -<td align="right">4.544</td> -<td align="right">2.302</td> -<td align="right">3.463</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">i7-4710MQ</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">0.678</td> -<td align="right">1.095</td> -<td align="right">1.149</td> -<td align="right">3.247</td> -<td align="right">1.658</td> -<td align="right">2.472</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.1</td> -<td align="right">0.696</td> -<td align="right">1.124</td> -<td align="right">1.321</td> -<td align="right">2.786</td> -<td align="right">1.744</td> -<td align="right">2.566</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.1</td> -<td align="left">1.1.2</td> -<td align="right">0.861</td> -<td align="right">1.295</td> -<td align="right">1.507</td> -<td align="right">3.102</td> -<td align="right">1.961</td> -<td align="right">2.852</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">0.913</td> -<td align="right">1.345</td> -<td align="right">1.539</td> -<td align="right">3.011</td> -<td align="right">1.987</td> -<td align="right">2.802</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 7 1700</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">0.935</td> -<td align="right">1.381</td> -<td align="right">1.551</td> -<td align="right">3.209</td> -<td align="right">1.976</td> -<td align="right">3.013</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.0</td> -<td align="right">0.445</td> -<td align="right">0.591</td> -<td align="right">0.660</td> -<td align="right">1.190</td> -<td align="right">0.814</td> -<td align="right">1.100</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.2</td> -<td align="right">0.443</td> -<td align="right">0.586</td> -<td align="right">0.661</td> -<td align="right">1.176</td> -<td align="right">0.803</td> -<td align="right">1.097</td> -</tr> -<tr class="even"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.2</td> -<td align="left">1.2.3</td> -<td align="right">0.418</td> -<td align="right">0.530</td> -<td align="right">0.591</td> -<td align="right">1.006</td> -<td align="right">0.716</td> -<td align="right">0.949</td> -</tr> -<tr class="odd"> -<td align="left">Linux</td> -<td align="left">Ryzen 9 7950X</td> -<td align="left">4.2.3</td> -<td align="left">1.2.3</td> -<td align="right">0.432</td> -<td align="right">0.551</td> -<td align="right">0.616</td> -<td align="right">1.039</td> -<td align="right">0.734</td> -<td align="right">0.981</td> -</tr> -</tbody> -</table> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/web_only/benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/web_only/benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/web_only/benchmarks_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted 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</li> - <li> - <a href="../../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Performance benefit by using compiled model -definitions in mkin</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">2023-04-16</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/compiled_models.rmd" class="external-link"><code>vignettes/web_only/compiled_models.rmd</code></a></small> - <div class="hidden name"><code>compiled_models.rmd</code></div> - - </div> - - - -<div class="section level2"> -<h2 id="how-to-benefit-from-compiled-models">How to benefit from compiled models<a class="anchor" aria-label="anchor" href="#how-to-benefit-from-compiled-models"></a> -</h2> -<p>When using an mkin version equal to or greater than 0.9-36 and a C -compiler is available, you will see a message that the model is being -compiled from autogenerated C code when defining a model using mkinmod. -Starting from version 0.9.49.9, the <code><a href="../../reference/mkinmod.html">mkinmod()</a></code> function -checks for presence of a compiler using</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu">pkgbuild</span><span class="fu">::</span><span class="fu"><a href="https://r-lib.github.io/pkgbuild/reference/has_compiler.html" class="external-link">has_compiler</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<p>In previous versions, it used <code>Sys.which("gcc")</code> for this -check.</p> -<p>On Linux, you need to have the essential build tools like make and -gcc or clang installed. On Debian based linux distributions, these will -be pulled in by installing the build-essential package.</p> -<p>On MacOS, which I do not use personally, I have had reports that a -compiler is available by default.</p> -<p>On Windows, you need to install Rtools and have the path to its bin -directory in your PATH variable. You do not need to modify the PATH -variable when installing Rtools. Instead, I would recommend to put the -line</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/Sys.setenv.html" class="external-link">Sys.setenv</a></span><span class="op">(</span>PATH <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"C:/Rtools/bin"</span>, <span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"PATH"</span><span class="op">)</span>, sep<span class="op">=</span><span class="st">";"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p>into your .Rprofile startup file. This is just a text file with some -R code that is executed when your R session starts. It has to be named -.Rprofile and has to be located in your home directory, which will -generally be your Documents folder. You can check the location of the -home directory used by R by issuing</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"HOME"</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="comparison-with-other-solution-methods">Comparison with other solution methods<a class="anchor" aria-label="anchor" href="#comparison-with-other-solution-methods"></a> -</h2> -<p>First, we build a simple degradation model for a parent compound with -one metabolite, and we remove zero values from the dataset.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="st"><a href="https://pkgdown.jrwb.de/mkin/">"mkin"</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> -<span> m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span></code></pre></div> -<p>We can compare the performance of the Eigenvalue based solution -against the compiled version and the R implementation of the -differential equations using the benchmark package. In the output of -below code, the warnings about zero being removed from the FOCUS D -dataset are suppressed. Since mkin version 0.9.49.11, an analytical -solution is also implemented, which is included in the tests below.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">b.1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span> -<span> <span class="st">"deSolve, not compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> <span class="st">"Eigenvalue based"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"eigen"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> <span class="st">"deSolve, compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> <span class="st">"analytical"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"analytical"</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>,</span> -<span> columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">b.1</span><span class="op">)</span></span> -<span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="st">"R package rbenchmark is not available"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<pre><code><span><span class="co">## test replications relative elapsed</span></span> -<span><span class="co">## 4 analytical 1 1.000 0.105</span></span> -<span><span class="co">## 3 deSolve, compiled 1 1.276 0.134</span></span> -<span><span class="co">## 2 Eigenvalue based 1 1.762 0.185</span></span> -<span><span class="co">## 1 deSolve, not compiled 1 21.914 2.301</span></span></code></pre> -<p>We see that using the compiled model is by more than a factor of 10 -faster than using deSolve without compiled code.</p> -</div> -<div class="section level2"> -<h2 id="model-without-analytical-solution">Model without analytical solution<a class="anchor" aria-label="anchor" href="#model-without-analytical-solution"></a> -</h2> -<p>This evaluation is also taken from the example section of mkinfit. No -analytical solution is available for this system, and now Eigenvalue -based solution is possible, so only deSolve using with or without -compiled code is available.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> parent <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> -<span> m1 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span> -<span></span> -<span> <span class="va">b.2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span> -<span> <span class="st">"deSolve, not compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="cn">FALSE</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> <span class="st">"deSolve, compiled"</span> <span class="op">=</span> <span class="fu"><a href="../../reference/mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>,</span> -<span> columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"replications"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span><span class="op">)</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">)</span></span> -<span> <span class="va">factor_FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="va">b.2</span><span class="op">[</span><span class="st">"1"</span>, <span class="st">"relative"</span><span class="op">]</span><span class="op">)</span></span> -<span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span> -<span> <span class="va">factor_FOMC_SFO</span> <span class="op"><-</span> <span class="cn">NA</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="st">"R package benchmark is not available"</span><span class="op">)</span></span> -<span><span class="op">}</span></span></code></pre></div> -<pre><code><span><span class="co">## Temporary DLL for differentials generated and loaded</span></span></code></pre> -<pre><code><span><span class="co">## test replications relative elapsed</span></span> -<span><span class="co">## 2 deSolve, compiled 1 1.000 0.176</span></span> -<span><span class="co">## 1 deSolve, not compiled 1 23.938 4.213</span></span></code></pre> -<p>Here we get a performance benefit of a factor of 24 using the version -of the differential equation model compiled from C code!</p> -<p>This vignette was built with mkin 1.2.3 on</p> -<pre><code><span><span class="co">## R version 4.2.3 (2023-03-15)</span></span> -<span><span class="co">## Platform: x86_64-pc-linux-gnu (64-bit)</span></span> -<span><span class="co">## Running under: Debian GNU/Linux 12 (bookworm)</span></span></code></pre> -<pre><code><span><span class="co">## CPU model: AMD Ryzen 9 7950X 16-Core Processor</span></span></code></pre> -</div> - 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</li> - <li> - <a href="../../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Example evaluations of the dimethenamid data -from 2018</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 1 July 2022, -built on 16 Apr 2023</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/dimethenamid_2018.rmd" class="external-link"><code>vignettes/web_only/dimethenamid_2018.rmd</code></a></small> - <div class="hidden name"><code>dimethenamid_2018.rmd</code></div> - - </div> - - - -<p><a href="http://www.jrwb.de" class="external-link">Wissenschaftlicher Berater, Kronacher -Str. 12, 79639 Grenzach-Wyhlen, Germany</a></p> -<div class="section level2"> -<h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#introduction"></a> -</h2> -<p>A first analysis of the data analysed here was presented in a recent -journal article on nonlinear mixed-effects models in degradation -kinetics <span class="citation">(Ranke et al. 2021)</span>. That -analysis was based on the <code>nlme</code> package and a development -version of the <code>saemix</code> package that was unpublished at the -time. Meanwhile, version 3.0 of the <code>saemix</code> package is -available from the CRAN repository. Also, it turned out that there was -an error in the handling of the Borstel data in the mkin package at the -time, leading to the duplication of a few data points from that soil. -The dataset in the mkin package has been corrected, and the interface to -<code>saemix</code> in the mkin package has been updated to use the -released version.</p> -<p>This vignette is intended to present an up to date analysis of the -data, using the corrected dataset and released versions of -<code>mkin</code> and <code>saemix</code>.</p> -</div> -<div class="section level2"> -<h2 id="data">Data<a class="anchor" aria-label="anchor" href="#data"></a> -</h2> -<p>Residue data forming the basis for the endpoints derived in the -conclusion on the peer review of the pesticide risk assessment of -dimethenamid-P published by the European Food Safety Authority (EFSA) in -2018 <span class="citation">(EFSA 2018)</span> were transcribed from the -risk assessment report <span class="citation">(Rapporteur Member State -Germany, Co-Rapporteur Member State Bulgaria 2018)</span> which can be -downloaded from the Open EFSA repository <a href="https://open.efsa.europa.eu" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a>.</p> -<p>The data are <a href="https://pkgdown.jrwb.de/mkin/reference/dimethenamid_2018.html">available -in the mkin package</a>. The following code (hidden by default, please -use the button to the right to show it) treats the data available for -the racemic mixture dimethenamid (DMTA) and its enantiomer -dimethenamid-P (DMTAP) in the same way, as no difference between their -degradation behaviour was identified in the EU risk assessment. The -observation times of each dataset are multiplied with the corresponding -normalisation factor also available in the dataset, in order to make it -possible to describe all datasets with a single set of parameters.</p> -<p>Also, datasets observed in the same soil are merged, resulting in -dimethenamid (DMTA) data from six soils.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span> -<span> <span class="va">ds_i</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="parent-degradation">Parent degradation<a class="anchor" aria-label="anchor" href="#parent-degradation"></a> -</h2> -<p>We evaluate the observed degradation of the parent compound using -simple exponential decline (SFO) and biexponential decline (DFOP), using -constant variance (const) and a two-component variance (tc) as error -models.</p> -<div class="section level3"> -<h3 id="separate-evaluations">Separate evaluations<a class="anchor" aria-label="anchor" href="#separate-evaluations"></a> -</h3> -<p>As a first step, to get a visual impression of the fit of the -different models, we do separate evaluations for each soil using the -mmkin function from the mkin package:</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_mkin_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">dmta_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"const"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">f_parent_mkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">dmta_ds</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<p>The plot of the individual SFO fits shown below suggests that at -least in some datasets the degradation slows down towards later time -points, and that the scatter of the residuals error is smaller for -smaller values (panel to the right):</p> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_sfo_const-1.png" width="700"></p> -<p>Using biexponential decline (DFOP) results in a slightly more random -scatter of the residuals:</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_const-1.png" width="700"></p> -<p>The population curve (bold line) in the above plot results from -taking the mean of the individual transformed parameters, i.e. of log k1 -and log k2, as well as of the logit of the g parameter of the DFOP -model). Here, this procedure does not result in parameters that -represent the degradation well, because in some datasets the fitted -value for k2 is extremely close to zero, leading to a log k2 value that -dominates the average. This is alleviated if only rate constants that -pass the t-test for significant difference from zero (on the -untransformed scale) are considered in the averaging:</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_const_test-1.png" width="700"></p> -<p>While this is visually much more satisfactory, such an average -procedure could introduce a bias, as not all results from the individual -fits enter the population curve with the same weight. This is where -nonlinear mixed-effects models can help out by treating all datasets -with equally by fitting a parameter distribution model together with the -degradation model and the error model (see below).</p> -<p>The remaining trend of the residuals to be higher for higher -predicted residues is reduced by using the two-component error -model:</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="../../reference/mixed.html">mixed</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_mkin_dfop_tc_test-1.png" width="700"></p> -<p>However, note that in the case of using this error model, the fits to -the Flaach and BBA 2.3 datasets appear to be ill-defined, indicated by -the fact that they did not converge:</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span></code></pre></div> -<pre><code><mmkin> object -Status of individual fits: - - dataset -model Calke Borstel Flaach BBA 2.2 BBA 2.3 Elliot - DFOP OK OK C OK C OK - -C: Optimisation did not converge: -iteration limit reached without convergence (10) -OK: No warnings</code></pre> -</div> -<div class="section level3"> -<h3 id="nonlinear-mixed-effects-models">Nonlinear mixed-effects models<a class="anchor" aria-label="anchor" href="#nonlinear-mixed-effects-models"></a> -</h3> -<p>Instead of taking a model selection decision for each of the -individual fits, we fit nonlinear mixed-effects models (using different -fitting algorithms as implemented in different packages) and do model -selection using all available data at the same time. In order to make -sure that these decisions are not unduly influenced by the type of -algorithm used, by implementation details or by the use of wrong control -parameters, we compare the model selection results obtained with -different R packages, with different algorithms and checking control -parameters.</p> -<div class="section level4"> -<h4 id="nlme">nlme<a class="anchor" aria-label="anchor" href="#nlme"></a> -</h4> -<p>The nlme package was the first R extension providing facilities to -fit nonlinear mixed-effects models. We would like to do model selection -from all four combinations of degradation models and error models based -on the AIC. However, fitting the DFOP model with constant variance and -using default control parameters results in an error, signalling that -the maximum number of 50 iterations was reached, potentially indicating -overparameterisation. Nevertheless, the algorithm converges when the -two-component error model is used in combination with the DFOP model. -This can be explained by the fact that the smaller residues observed at -later sampling times get more weight when using the two-component error -model which will counteract the tendency of the algorithm to try -parameter combinations unsuitable for fitting these data.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span> -<span><span class="va">f_parent_nlme_sfo_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> -<span><span class="co"># f_parent_nlme_dfop_const <- nlme(f_parent_mkin_const["DFOP", ])</span></span> -<span><span class="va">f_parent_nlme_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span> -<span><span class="va">f_parent_nlme_dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span></code></pre></div> -<p>Note that a certain degree of overparameterisation is also indicated -by a warning obtained when fitting DFOP with the two-component error -model (‘false convergence’ in the ‘LME step’ in iteration 3). However, -as this warning does not occur in later iterations, and specifically not -in the last of the 5 iterations, we can ignore this warning.</p> -<p>The model comparison function of the nlme package can directly be -applied to these fits showing a much lower AIC for the DFOP model fitted -with the two-component error model. Also, the likelihood ratio test -indicates that this difference is significant as the p-value is below -0.0001.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span></span> -<span> <span class="va">f_parent_nlme_sfo_const</span>, <span class="va">f_parent_nlme_sfo_tc</span>, <span class="va">f_parent_nlme_dfop_tc</span></span> -<span><span class="op">)</span></span></code></pre></div> -<pre><code> Model df AIC BIC logLik Test L.Ratio p-value -f_parent_nlme_sfo_const 1 5 796.60 811.82 -393.30 -f_parent_nlme_sfo_tc 2 6 798.60 816.86 -393.30 1 vs 2 0.00 0.998 -f_parent_nlme_dfop_tc 3 10 671.91 702.34 -325.96 2 vs 3 134.69 <.0001</code></pre> -<p>In addition to these fits, attempts were also made to include -correlations between random effects by using the log Cholesky -parameterisation of the matrix specifying them. The code used for these -attempts can be made visible below.</p> -<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_nlme_sfo_const_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>,</span> -<span> random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k_DMTA</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_const</span>, <span class="va">f_parent_nlme_sfo_const_logchol</span><span class="op">)</span></span> -<span><span class="va">f_parent_nlme_sfo_tc_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>,</span> -<span> random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k_DMTA</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_tc</span>, <span class="va">f_parent_nlme_sfo_tc_logchol</span><span class="op">)</span></span> -<span><span class="va">f_parent_nlme_dfop_tc_logchol</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>,</span> -<span> random <span class="op">=</span> <span class="fu">nlme</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdLogChol.html" class="external-link">pdLogChol</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">DMTA_0</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k1</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">log_k2</span> <span class="op">~</span> <span class="fl">1</span>, <span class="va">g_qlogis</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span>, <span class="va">f_parent_nlme_dfop_tc_logchol</span><span class="op">)</span></span></code></pre></div> -<p>While the SFO variants converge fast, the additional parameters -introduced by this lead to convergence warnings for the DFOP model. The -model comparison clearly show that adding correlations between random -effects does not improve the fits.</p> -<p>The selected model (DFOP with two-component error) fitted to the data -assuming no correlations between random effects is shown below.</p> -<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/plot_parent_nlme-1.png" width="700"></p> -</div> -<div class="section level4"> -<h4 id="saemix">saemix<a class="anchor" aria-label="anchor" href="#saemix"></a> -</h4> -<p>The saemix package provided the first Open Source implementation of -the Stochastic Approximation to the Expectation Maximisation (SAEM) -algorithm. SAEM fits of degradation models can be conveniently performed -using an interface to the saemix package available in current -development versions of the mkin package.</p> -<p>The corresponding SAEM fits of the four combinations of degradation -and error models are fitted below. As there is no convergence criterion -implemented in the saemix package, the convergence plots need to be -manually checked for every fit. We define control settings that work -well for all the parent data fits shown in this vignette.</p> -<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span> -<span><span class="va">saemix_control</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">800</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>,</span> -<span> print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> -<span><span class="va">saemix_control_moreiter</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1600</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>,</span> -<span> print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> -<span><span class="va">saemix_control_10k</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/saemixControl.html" class="external-link">saemixControl</a></span><span class="op">(</span>nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10000</span>, <span class="fl">300</span><span class="op">)</span>, nb.chains <span class="op">=</span> <span class="fl">15</span>,</span> -<span> print <span class="op">=</span> <span class="cn">FALSE</span>, save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span>, displayProgress <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> -<p>The convergence plot for the SFO model using constant variance is -shown below.</p> -<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_sfo_const</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_sfo_const-1.png" width="700"></p> -<p>Obviously the selected number of iterations is sufficient to reach -convergence. This can also be said for the SFO fit using the -two-component error model.</p> -<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_sfo_tc</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_sfo_tc-1.png" width="700"></p> -<p>When fitting the DFOP model with constant variance (see below), -parameter convergence is not as unambiguous.</p> -<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_dfop_const</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_dfop_const-1.png" width="700"></p> -<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_const</span><span class="op">)</span></span></code></pre></div> -<pre><code>Kinetic nonlinear mixed-effects model fit by SAEM -Structural model: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Likelihood computed by importance sampling - AIC BIC logLik - 706 704 -344 - -Fitted parameters: - estimate lower upper -DMTA_0 97.99583 96.50079 99.4909 -k1 0.06377 0.03432 0.0932 -k2 0.00848 0.00444 0.0125 -g 0.95701 0.91313 1.0009 -a.1 1.82141 1.65122 1.9916 -SD.DMTA_0 1.64787 0.45772 2.8380 -SD.k1 0.57439 0.24731 0.9015 -SD.k2 0.03296 -2.50195 2.5679 -SD.g 1.10266 0.32369 1.8816</code></pre> -<p>While the other parameters converge to credible values, the variance -of k2 (<code>omega2.k2</code>) converges to a very small value. The -printout of the <code>saem.mmkin</code> model shows that the estimated -standard deviation of k2 across the population of soils -(<code>SD.k2</code>) is ill-defined, indicating overparameterisation of -this model.</p> -<p>When the DFOP model is fitted with the two-component error model, we -also observe that the estimated variance of k2 becomes very small, while -being ill-defined, as illustrated by the excessive confidence interval -of <code>SD.k2</code>.</p> -<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_dfop_tc</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> control <span class="op">=</span> <span class="va">saemix_control</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> -<span><span class="va">f_parent_saemix_dfop_tc_moreiter</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> control <span class="op">=</span> <span class="va">saemix_control_moreiter</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></code></pre></div> -<p><img src="dimethenamid_2018_files/figure-html/f_parent_saemix_dfop_tc-1.png" width="700"></p> -<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">)</span></span></code></pre></div> -<pre><code>Kinetic nonlinear mixed-effects model fit by SAEM -Structural model: -d_DMTA/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 * - time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time))) - * DMTA - -Data: -155 observations of 1 variable(s) grouped in 6 datasets - -Likelihood computed by importance sampling - AIC BIC logLik - 666 664 -323 - -Fitted parameters: - estimate lower upper -DMTA_0 98.27617 96.3088 100.2436 -k1 0.06437 0.0337 0.0950 -k2 0.00880 0.0063 0.0113 -g 0.95249 0.9100 0.9949 -a.1 1.06161 0.8625 1.2607 -b.1 0.02967 0.0226 0.0367 -SD.DMTA_0 2.06075 0.4187 3.7028 -SD.k1 0.59357 0.2561 0.9310 -SD.k2 0.00292 -10.2960 10.3019 -SD.g 1.05725 0.3808 1.7337</code></pre> -<p>Doubling the number of iterations in the first phase of the algorithm -leads to a slightly lower likelihood, and therefore to slightly higher -AIC and BIC values. With even more iterations, the algorithm stops with -an error message. This is related to the variance of k2 approximating -zero and has been submitted as a <a href="https://github.com/saemixdevelopment/saemixextension/issues/29" class="external-link">bug -to the saemix package</a>, as the algorithm does not converge in this -case.</p> -<p>An alternative way to fit DFOP in combination with the two-component -error model is to use the model formulation with transformed parameters -as used per default in mkin. When using this option, convergence is -slower, but eventually the algorithm stops as well with the same error -message.</p> -<p>The four combinations (SFO/const, SFO/tc, DFOP/const and DFOP/tc) and -the version with increased iterations can be compared using the model -comparison function of the saemix package:</p> -<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">AIC_parent_saemix</span> <span class="op"><-</span> <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span></span> -<span> <span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_dfop_tc_moreiter</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span></code></pre></div> -<pre><code>Likelihoods calculated by importance sampling</code></pre> -<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">AIC_parent_saemix</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> -<span> <span class="st">"SFO const"</span>, <span class="st">"SFO tc"</span>, <span class="st">"DFOP const"</span>, <span class="st">"DFOP tc"</span>, <span class="st">"DFOP tc more iterations"</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix</span><span class="op">)</span></span></code></pre></div> -<pre><code> AIC BIC -SFO const 796.38 795.34 -SFO tc 798.38 797.13 -DFOP const 705.75 703.88 -DFOP tc 665.65 663.57 -DFOP tc more iterations 665.88 663.80</code></pre> -<p>In order to check the influence of the likelihood calculation -algorithms implemented in saemix, the likelihood from Gaussian -quadrature is added to the best fit, and the AIC values obtained from -the three methods are compared.</p> -<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span> <span class="op"><-</span></span> -<span> <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/llgq.saemix.html" class="external-link">llgq.saemix</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span> -<span><span class="va">AIC_parent_saemix_methods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> -<span> is <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"is"</span><span class="op">)</span>,</span> -<span> gq <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"gq"</span><span class="op">)</span>,</span> -<span> lin <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"lin"</span><span class="op">)</span></span> -<span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix_methods</span><span class="op">)</span></span></code></pre></div> -<pre><code> is gq lin -665.65 665.68 665.11 </code></pre> -<p>The AIC values based on importance sampling and Gaussian quadrature -are very similar. Using linearisation is known to be less accurate, but -still gives a similar value.</p> -<p>In order to illustrate that the comparison of the three method -depends on the degree of convergence obtained in the fit, the same -comparison is shown below for the fit using the defaults for the number -of iterations and the number of MCMC chains.</p> -<p>When using OpenBlas for linear algebra, there is a large difference -in the values obtained with Gaussian quadrature, so the larger number of -iterations makes a lot of difference. When using the LAPACK version -coming with Debian Bullseye, the AIC based on Gaussian quadrature is -almost the same as the one obtained with the other methods, also when -using defaults for the fit.</p> -<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_parent_saemix_dfop_tc_defaults</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_parent_mkin_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span> -<span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span> <span class="op"><-</span></span> -<span> <span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/llgq.saemix.html" class="external-link">llgq.saemix</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span> -<span><span class="va">AIC_parent_saemix_methods_defaults</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> -<span> is <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"is"</span><span class="op">)</span>,</span> -<span> gq <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"gq"</span><span class="op">)</span>,</span> -<span> lin <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_saemix_dfop_tc_defaults</span><span class="op">$</span><span class="va">so</span>, method <span class="op">=</span> <span class="st">"lin"</span><span class="op">)</span></span> -<span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">AIC_parent_saemix_methods_defaults</span><span class="op">)</span></span></code></pre></div> -<pre><code> is gq lin -669.77 669.36 670.95 </code></pre> -</div> -</div> -<div class="section level3"> -<h3 id="comparison">Comparison<a class="anchor" aria-label="anchor" href="#comparison"></a> -</h3> -<p>The following table gives the AIC values obtained with both backend -packages using the same control parameters (800 iterations burn-in, 300 -iterations second phase, 15 chains).</p> -<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">AIC_all</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span> -<span> check.names <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> <span class="st">"Degradation model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"SFO"</span>, <span class="st">"DFOP"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span> -<span> <span class="st">"Error model"</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"const"</span>, <span class="st">"tc"</span>, <span class="st">"const"</span>, <span class="st">"tc"</span><span class="op">)</span>,</span> -<span> nlme <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_const</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_sfo_tc</span><span class="op">)</span>, <span class="cn">NA</span>, <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_parent_nlme_dfop_tc</span><span class="op">)</span><span class="op">)</span>,</span> -<span> saemix_lin <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span>, <span class="va">AIC</span>, method <span class="op">=</span> <span class="st">"lin"</span><span class="op">)</span>,</span> -<span> saemix_is <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_parent_saemix_sfo_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_sfo_tc</span><span class="op">$</span><span class="va">so</span>,</span> -<span> <span class="va">f_parent_saemix_dfop_const</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_parent_saemix_dfop_tc</span><span class="op">$</span><span class="va">so</span><span class="op">)</span>, <span class="va">AIC</span>, method <span class="op">=</span> <span class="st">"is"</span><span class="op">)</span></span> -<span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span><span class="va">AIC_all</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left">Degradation model</th> -<th align="left">Error model</th> -<th align="right">nlme</th> -<th align="right">saemix_lin</th> -<th align="right">saemix_is</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">SFO</td> -<td align="left">const</td> -<td align="right">796.60</td> -<td align="right">796.60</td> -<td align="right">796.38</td> -</tr> -<tr class="even"> -<td align="left">SFO</td> -<td align="left">tc</td> -<td align="right">798.60</td> -<td align="right">798.60</td> -<td align="right">798.38</td> -</tr> -<tr class="odd"> -<td align="left">DFOP</td> -<td align="left">const</td> -<td align="right">NA</td> -<td align="right">709.26</td> -<td align="right">705.75</td> -</tr> -<tr class="even"> -<td align="left">DFOP</td> -<td align="left">tc</td> -<td align="right">671.91</td> -<td align="right">665.11</td> -<td align="right">665.65</td> -</tr> -</tbody> -</table> -</div> -</div> -<div class="section level2"> -<h2 id="conclusion">Conclusion<a class="anchor" aria-label="anchor" href="#conclusion"></a> -</h2> -<p>A more detailed analysis of the dimethenamid dataset confirmed that -the DFOP model provides the most appropriate description of the decline -of the parent compound in these data. On the other hand, closer -inspection of the results revealed that the variability of the k2 -parameter across the population of soils is ill-defined. This coincides -with the observation that this parameter cannot robustly be quantified -for some of the soils.</p> -<p>Regarding the regulatory use of these data, it is claimed that an -improved characterisation of the mean parameter values across the -population is obtained using the nonlinear mixed-effects models -presented here. However, attempts to quantify the variability of the -slower rate constant of the biphasic decline of dimethenamid indicate -that the data are not sufficient to characterise this variability to a -satisfactory precision.</p> -</div> -<div class="section level2"> -<h2 id="session-info">Session Info<a class="anchor" aria-label="anchor" href="#session-info"></a> -</h2> -<div class="sourceCode" id="cb32"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/sessionInfo.html" class="external-link">sessionInfo</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<pre><code>R version 4.2.3 (2023-03-15) -Platform: x86_64-pc-linux-gnu (64-bit) -Running under: Debian GNU/Linux 12 (bookworm) - -Matrix products: default -BLAS: /usr/lib/x86_64-linux-gnu/openblas-serial/libblas.so.3 -LAPACK: /usr/lib/x86_64-linux-gnu/openblas-serial/libopenblas-r0.3.21.so - -locale: - [1] LC_CTYPE=de_DE.UTF-8 LC_NUMERIC=C - [3] LC_TIME=C LC_COLLATE=de_DE.UTF-8 - [5] LC_MONETARY=de_DE.UTF-8 LC_MESSAGES=de_DE.UTF-8 - [7] LC_PAPER=de_DE.UTF-8 LC_NAME=C - [9] LC_ADDRESS=C LC_TELEPHONE=C -[11] LC_MEASUREMENT=de_DE.UTF-8 LC_IDENTIFICATION=C - -attached base packages: -[1] stats graphics grDevices utils datasets methods base - -other attached packages: -[1] saemix_3.2 npde_3.3 nlme_3.1-162 mkin_1.2.3 knitr_1.42 - -loaded via a namespace (and not attached): - [1] highr_0.10 pillar_1.9.0 bslib_0.4.2 compiler_4.2.3 - [5] jquerylib_0.1.4 tools_4.2.3 mclust_6.0.0 digest_0.6.31 - [9] tibble_3.2.1 jsonlite_1.8.4 evaluate_0.20 memoise_2.0.1 -[13] lifecycle_1.0.3 gtable_0.3.3 lattice_0.21-8 pkgconfig_2.0.3 -[17] rlang_1.1.0 DBI_1.1.3 cli_3.6.1 yaml_2.3.7 -[21] parallel_4.2.3 pkgdown_2.0.7 xfun_0.38 fastmap_1.1.1 -[25] gridExtra_2.3 dplyr_1.1.1 stringr_1.5.0 generics_0.1.3 -[29] desc_1.4.2 fs_1.6.1 vctrs_0.6.1 sass_0.4.5 -[33] systemfonts_1.0.4 tidyselect_1.2.0 rprojroot_2.0.3 lmtest_0.9-40 -[37] grid_4.2.3 glue_1.6.2 R6_2.5.1 textshaping_0.3.6 -[41] fansi_1.0.4 rmarkdown_2.21 purrr_1.0.1 ggplot2_3.4.2 -[45] magrittr_2.0.3 codetools_0.2-19 scales_1.2.1 htmltools_0.5.5 -[49] colorspace_2.1-0 ragg_1.2.5 utf8_1.2.3 stringi_1.7.12 -[53] munsell_0.5.0 cachem_1.0.7 zoo_1.8-12 </code></pre> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<!-- vim: set foldmethod=syntax: --> -<div id="refs" class="references csl-bib-body hanging-indent"> -<div id="ref-efsa_2018_dimethenamid" class="csl-entry"> -EFSA. 2018. <span>“Peer Review of the Pesticide Risk Assessment of the -Active Substance Dimethenamid-p.”</span> <em>EFSA Journal</em> 16: 5211. -</div> -<div id="ref-ranke2021" class="csl-entry"> -Ranke, Johannes, Janina Wöltjen, Jana Schmidt, and Emmanuelle Comets. -2021. <span>“Taking Kinetic Evaluations of Degradation Data to the Next -Level with Nonlinear Mixed-Effects Models.”</span> <em>Environments</em> -8 (8). <a href="https://doi.org/10.3390/environments8080071" class="external-link">https://doi.org/10.3390/environments8080071</a>. -</div> -<div id="ref-dimethenamid_rar_2018_b8" class="csl-entry"> -Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria. -2018. <span>“<span class="nocase">Renewal Assessment Report -Dimethenamid-P Volume 3 - B.8 Environmental fate and behaviour, Rev. 2 - -November 2017</span>.”</span> <a href="https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a>. -</div> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" 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We remove the former (to -// be compatible with the behavior of Pandoc < 2.8). -document.addEventListener('DOMContentLoaded', function(e) { - var hs = document.querySelectorAll("div.section[class*='level'] > :first-child"); - var i, h, a; - for (i = 0; i < hs.length; i++) { - h = hs[i]; - if (!/^h[1-6]$/i.test(h.tagName)) continue; // it should be a header h1-h6 - a = h.attributes; - while (a.length > 0) h.removeAttribute(a[0].name); - } -}); diff --git a/docs/dev/articles/web_only/dimethenamid_2018_files/header-attrs-2.9/header-attrs.js b/docs/dev/articles/web_only/dimethenamid_2018_files/header-attrs-2.9/header-attrs.js deleted file mode 100644 index dd57d92e..00000000 --- a/docs/dev/articles/web_only/dimethenamid_2018_files/header-attrs-2.9/header-attrs.js +++ /dev/null @@ -1,12 +0,0 @@ -// Pandoc 2.9 adds attributes on both header and div. 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</li> - <li> - <a href="../../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Performance</li> - <li> - <a href="../../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Short demo of the multistart method</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 20 April 2023 -(rebuilt 2023-04-20)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/multistart.rmd" class="external-link"><code>vignettes/web_only/multistart.rmd</code></a></small> - <div class="hidden name"><code>multistart.rmd</code></div> - - </div> - - - -<p>The dimethenamid data from 2018 from seven soils is used as example -data in this vignette.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span> -<span> <span class="va">ds_i</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -<p>First, we check the DFOP model with the two-component error model and -random effects for all degradation parameters.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">7</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">f_saem_full</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_full</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## [1] "sd(log_k2)"</span></span></code></pre> -<p>We see that not all variability parameters are identifiable. The -<code>illparms</code> function tells us that the confidence interval for -the standard deviation of ‘log_k2’ includes zero. We check this -assessment using multiple runs with different starting values.</p> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_full_multi</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem_full</span>, n <span class="op">=</span> <span class="fl">16</span>, cores <span class="op">=</span> <span class="fl">16</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_full_multi</span>, lpos <span class="op">=</span> <span class="st">"topleft"</span><span class="op">)</span></span></code></pre></div> -<p><img src="multistart_files/figure-html/unnamed-chunk-3-1.png" width="700"></p> -<p>This confirms that the variance of k2 is the most problematic -parameter, so we reduce the parameter distribution model by removing the -intersoil variability for k2.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">f_saem_reduced</span> <span class="op"><-</span> <span class="fu">stats</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_full</span>, no_random_effect <span class="op">=</span> <span class="st">"log_k2"</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_reduced</span><span class="op">)</span></span> -<span><span class="va">f_saem_reduced_multi</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/multistart.html">multistart</a></span><span class="op">(</span><span class="va">f_saem_reduced</span>, n <span class="op">=</span> <span class="fl">16</span>, cores <span class="op">=</span> <span class="fl">16</span><span class="op">)</span></span> -<span><span class="fu"><a href="../../reference/parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_reduced_multi</span>, lpos <span class="op">=</span> <span class="st">"topright"</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> -<p><img src="multistart_files/figure-html/unnamed-chunk-4-1.png" width="700"></p> -<p>The results confirm that all remaining parameters can be determined -with sufficient certainty.</p> -<p>We can also analyse the log-likelihoods obtained in the multiple -runs:</p> -<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/llhist.html">llhist</a></span><span class="op">(</span><span class="va">f_saem_reduced_multi</span><span class="op">)</span></span></code></pre></div> -<p><img src="multistart_files/figure-html/unnamed-chunk-5-1.png" width="700"></p> -<p>We can use the <code>anova</code> method to compare the models.</p> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_full</span>, <span class="fu"><a href="../../reference/multistart.html">best</a></span><span class="op">(</span><span class="va">f_saem_full_multi</span><span class="op">)</span>,</span> -<span> <span class="va">f_saem_reduced</span>, <span class="fu"><a href="../../reference/multistart.html">best</a></span><span class="op">(</span><span class="va">f_saem_reduced_multi</span><span class="op">)</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## Data: 155 observations of 1 variable(s) grouped in 6 datasets</span></span> -<span><span class="co">## </span></span> -<span><span class="co">## npar AIC BIC Lik Chisq Df Pr(>Chisq)</span></span> -<span><span class="co">## f_saem_reduced 9 663.73 661.86 -322.86 </span></span> -<span><span class="co">## best(f_saem_reduced_multi) 9 663.69 661.82 -322.85 0.0361 0 </span></span> -<span><span class="co">## f_saem_full 10 669.77 667.69 -324.89 0.0000 1 1</span></span> -<span><span class="co">## best(f_saem_full_multi) 10 665.56 663.48 -322.78 4.2060 0</span></span></code></pre> -<p>The reduced model results in lower AIC and BIC values, so it is -clearly preferable. Using multiple starting values gives a large -improvement in case of the full model, because it is less well-defined, -which impedes convergence. For the reduced model, using multiple -starting values only results in a small improvement of the model -fit.</p> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - </div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git a/docs/dev/articles/web_only/multistart_files/accessible-code-block-0.0.1/empty-anchor.js b/docs/dev/articles/web_only/multistart_files/accessible-code-block-0.0.1/empty-anchor.js deleted file mode 100644 index ca349fd6..00000000 --- a/docs/dev/articles/web_only/multistart_files/accessible-code-block-0.0.1/empty-anchor.js +++ /dev/null @@ -1,15 +0,0 @@ -// Hide empty <a> tag within highlighted CodeBlock for screen reader accessibility (see 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-</li> -<li> - <a href="../../news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header toc-ignore"> - <h1 data-toc-skip>Benchmark timings for saem.mmkin</h1> - <h4 data-toc-skip class="author">Johannes -Ranke</h4> - - <h4 data-toc-skip class="date">Last change 17 February 2023 -(rebuilt 2023-04-16)</h4> - - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/vignettes/web_only/saem_benchmarks.rmd" class="external-link"><code>vignettes/web_only/saem_benchmarks.rmd</code></a></small> - <div class="hidden name"><code>saem_benchmarks.rmd</code></div> - - </div> - - - -<p>Each system is characterized by operating system type, CPU type, mkin -version, saemix version and R version. A compiler was available, so if -no analytical solution was available, compiled ODE models are used.</p> -<p>Every fit is only performed once, so the accuracy of the benchmarks -is limited.</p> -<p>For the initial mmkin fits, we use all available cores.</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">n_cores</span> <span class="op"><-</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div> -<div class="section level2"> -<h2 id="test-data">Test data<a class="anchor" aria-label="anchor" href="#test-data"></a> -</h2> -<p>Please refer to the vignette <code>dimethenamid_2018</code> for an -explanation of the following preprocessing.</p> -<div class="sourceCode" id="cb2"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span> -<span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span> -<span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span> -<span> <span class="va">ds_i</span></span> -<span><span class="op">}</span><span class="op">)</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span> -<span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="test-cases">Test cases<a class="anchor" aria-label="anchor" href="#test-cases"></a> -</h2> -<div class="section level3"> -<h3 id="parent-only">Parent only<a class="anchor" aria-label="anchor" href="#parent-only"></a> -</h3> -<div class="sourceCode" id="cb3"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">parent_mods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span>, <span class="st">"SFORB"</span>, <span class="st">"HS"</span><span class="op">)</span></span> -<span><span class="va">parent_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">parent_mods</span>, <span class="va">dmta_ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span></span> -<span><span class="va">parent_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">parent_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span></span> -<span><span class="va">t1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sfo_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"SFORB"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t4</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">hs_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_const</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t5</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t6</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t7</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"SFORB"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t8</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">hs_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">parent_sep_tc</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -<div class="sourceCode" id="cb4"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span></span> -<span> <span class="va">sfo_const</span>, <span class="va">dfop_const</span>, <span class="va">sforb_const</span>, <span class="va">hs_const</span>,</span> -<span> <span class="va">sfo_tc</span>, <span class="va">dfop_tc</span>, <span class="va">sforb_tc</span>, <span class="va">hs_tc</span><span class="op">)</span> <span class="op">|></span> <span class="fu"><a href="https://rdrr.io/pkg/knitr/man/kable.html" class="external-link">kable</a></span><span class="op">(</span>, digits <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></code></pre></div> -<table class="table"> -<thead><tr class="header"> -<th align="left"></th> -<th align="right">npar</th> -<th align="right">AIC</th> -<th align="right">BIC</th> -<th align="right">Lik</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">sfo_const</td> -<td align="right">5</td> -<td align="right">796.3</td> -<td align="right">795.3</td> -<td align="right">-393.2</td> -</tr> -<tr class="even"> -<td align="left">sfo_tc</td> -<td align="right">6</td> -<td align="right">798.3</td> -<td align="right">797.1</td> -<td align="right">-393.2</td> -</tr> -<tr class="odd"> -<td align="left">dfop_const</td> -<td align="right">9</td> -<td align="right">709.4</td> -<td align="right">707.5</td> -<td align="right">-345.7</td> -</tr> -<tr class="even"> -<td align="left">sforb_const</td> -<td align="right">9</td> -<td align="right">710.0</td> -<td align="right">708.1</td> -<td align="right">-346.0</td> -</tr> -<tr class="odd"> -<td align="left">hs_const</td> -<td align="right">9</td> -<td align="right">713.7</td> -<td align="right">711.8</td> -<td align="right">-347.8</td> -</tr> -<tr class="even"> -<td align="left">dfop_tc</td> -<td align="right">10</td> -<td align="right">669.8</td> -<td align="right">667.7</td> -<td align="right">-324.9</td> -</tr> -<tr class="odd"> -<td align="left">sforb_tc</td> -<td align="right">10</td> -<td align="right">662.8</td> -<td align="right">660.7</td> -<td align="right">-321.4</td> -</tr> -<tr class="even"> -<td align="left">hs_tc</td> -<td align="right">10</td> -<td align="right">667.3</td> -<td align="right">665.2</td> -<td align="right">-323.6</td> -</tr> -</tbody> -</table> -<p>The above model comparison suggests to use the SFORB model with -two-component error. For comparison, we keep the DFOP model with -two-component error, as it competes with SFORB for biphasic curves.</p> -<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">dfop_tc</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## [1] "sd(log_k2)"</span></span></code></pre> -<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">sforb_tc</span><span class="op">)</span></span></code></pre></div> -<pre><code><span><span class="co">## [1] "sd(log_k_DMTA_bound_free)"</span></span></code></pre> -<p>For these two models, random effects for the transformed parameters -<code>k2</code> and <code>k_DMTA_bound_free</code> could not be -quantified.</p> -</div> -<div class="section level3"> -<h3 id="one-metabolite">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite"></a> -</h3> -<p>We remove parameters that were found to be ill-defined in the parent -only fits.</p> -<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">one_met_mods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span> DFOP_SFO <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"M23"</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> SFORB_SFO <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="st">"M23"</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> -<span></span> -<span><span class="va">one_met_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">one_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"const"</span>,</span> -<span> cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span><span class="va">one_met_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">one_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> -<span> cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="va">t9</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">dfop_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">one_met_sep_tc</span><span class="op">[</span><span class="st">"DFOP_SFO"</span>, <span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"log_k2"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span> -<span><span class="va">t10</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">one_met_sep_tc</span><span class="op">[</span><span class="st">"SFORB_SFO"</span>, <span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"log_k_DMTA_bound_free"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -</div> -<div class="section level3"> -<h3 id="three-metabolites">Three metabolites<a class="anchor" aria-label="anchor" href="#three-metabolites"></a> -</h3> -<p>For the case of three metabolites, we only keep the SFORB model in -order to limit the time for compiling this vignette, and as fitting in -parallel may disturb the benchmark. Again, we do not include random -effects that were ill-defined in previous fits of subsets of the -degradation model.</p> -<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="../../reference/illparms.html">illparms</a></span><span class="op">(</span><span class="va">sforb_sfo_tc</span><span class="op">)</span></span></code></pre></div> -<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="va">three_met_mods</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span> SFORB_SFO3_plus <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinmod</a></span><span class="op">(</span></span> -<span> DMTA <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span> -<span> M23 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M27 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span> -<span> M31 <span class="op">=</span> <span class="fu"><a href="../../reference/mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span> -<span></span> -<span><span class="va">three_met_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/mmkin.html">mmkin</a></span><span class="op">(</span><span class="va">three_met_mods</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> -<span> cores <span class="op">=</span> <span class="va">n_cores</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="va">t11</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">sforb_sfo3_plus_const</span> <span class="op"><-</span> <span class="fu"><a href="../../reference/saem.html">saem</a></span><span class="op">(</span><span class="va">three_met_sep_tc</span><span class="op">[</span><span class="st">"SFORB_SFO3_plus"</span>, <span class="op">]</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="st">"log_k_DMTA_bound_free"</span><span class="op">)</span><span class="op">)</span><span class="op">[[</span><span class="st">"elapsed"</span><span class="op">]</span><span class="op">]</span></span></code></pre></div> -</div> -</div> -<div class="section level2"> -<h2 id="results">Results<a class="anchor" aria-label="anchor" href="#results"></a> -</h2> -<p>Benchmarks for all available error models are shown. They are -intended for improving mkin, not for comparing CPUs or operating -systems. All trademarks belong to their respective owners.</p> -<div class="section level3"> -<h3 id="parent-only-1">Parent only<a class="anchor" aria-label="anchor" href="#parent-only-1"></a> -</h3> -<p>Constant variance for SFO, DFOP, SFORB and HS.</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">CPU</th> -<th align="left">OS</th> -<th align="left">mkin</th> -<th align="left">saemix</th> -<th align="right">t1</th> -<th align="right">t2</th> -<th align="right">t3</th> -<th align="right">t4</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.0</td> -<td align="left">3.2</td> -<td align="right">2.140</td> -<td align="right">4.626</td> -<td align="right">4.328</td> -<td align="right">4.998</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">2.427</td> -<td align="right">4.550</td> -<td align="right">4.217</td> -<td align="right">4.851</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.1</td> -<td align="left">3.2</td> -<td align="right">1.352</td> -<td align="right">2.813</td> -<td align="right">2.401</td> -<td align="right">2.074</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">1.328</td> -<td align="right">2.738</td> -<td align="right">2.336</td> -<td align="right">2.023</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">1.118</td> -<td align="right">2.036</td> -<td align="right">2.010</td> -<td align="right">2.088</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">1.389</td> -<td align="right">2.300</td> -<td align="right">1.880</td> -<td align="right">2.355</td> -</tr> -</tbody> -</table> -<p>Two-component error fits for SFO, DFOP, SFORB and HS.</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">CPU</th> -<th align="left">OS</th> -<th align="left">mkin</th> -<th align="left">saemix</th> -<th align="right">t5</th> -<th align="right">t6</th> -<th align="right">t7</th> -<th align="right">t8</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.0</td> -<td align="left">3.2</td> -<td align="right">5.678</td> -<td align="right">7.441</td> -<td align="right">8.000</td> -<td align="right">7.980</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">5.352</td> -<td align="right">7.201</td> -<td align="right">8.174</td> -<td align="right">8.401</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.1</td> -<td align="left">3.2</td> -<td align="right">2.388</td> -<td align="right">3.033</td> -<td align="right">3.532</td> -<td align="right">3.310</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">2.341</td> -<td align="right">2.968</td> -<td align="right">3.465</td> -<td align="right">3.341</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">2.159</td> -<td align="right">3.584</td> -<td align="right">3.307</td> -<td align="right">3.460</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">2.300</td> -<td align="right">3.075</td> -<td align="right">3.206</td> -<td align="right">3.471</td> -</tr> -</tbody> -</table> -</div> -<div class="section level3"> -<h3 id="one-metabolite-1">One metabolite<a class="anchor" aria-label="anchor" href="#one-metabolite-1"></a> -</h3> -<p>Two-component error for DFOP-SFO and SFORB-SFO.</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">CPU</th> -<th align="left">OS</th> -<th align="left">mkin</th> -<th align="left">saemix</th> -<th align="right">t9</th> -<th align="right">t10</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.0</td> -<td align="left">3.2</td> -<td align="right">24.465</td> -<td align="right">800.266</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">25.193</td> -<td align="right">798.580</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.1</td> -<td align="left">3.2</td> -<td align="right">11.247</td> -<td align="right">285.216</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">11.242</td> -<td align="right">284.258</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">11.796</td> -<td align="right">216.012</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">12.951</td> -<td align="right">294.082</td> -</tr> -</tbody> -</table> -</div> -<div class="section level3"> -<h3 id="three-metabolites-1">Three metabolites<a class="anchor" aria-label="anchor" href="#three-metabolites-1"></a> -</h3> -<p>Two-component error for SFORB-SFO3-plus</p> -<table class="table"> -<thead><tr class="header"> -<th align="left">CPU</th> -<th align="left">OS</th> -<th align="left">mkin</th> -<th align="left">saemix</th> -<th align="right">t11</th> -</tr></thead> -<tbody> -<tr class="odd"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.0</td> -<td align="left">3.2</td> -<td align="right">1289.198</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 7 1700</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">1312.445</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.1</td> -<td align="left">3.2</td> -<td align="right">489.939</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.2</td> -<td align="left">3.2</td> -<td align="right">482.970</td> -</tr> -<tr class="odd"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">392.364</td> -</tr> -<tr class="even"> -<td align="left">Ryzen 9 7950X</td> -<td align="left">Linux</td> -<td align="left">1.2.3</td> -<td align="left">3.2</td> -<td align="right">477.297</td> -</tr> -</tbody> -</table> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - - <nav id="toc" data-toggle="toc"><h2 data-toc-skip>Contents</h2> - </nav> -</div> - -</div> - - - - <footer><div class="copyright"> - <p></p> -<p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p> -<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer> -</div> - - - - - - - </body> -</html> diff --git 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href="articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="contents col-md-9"> - <div class="section level2 authors-section"> - <div class="page-header"> - <h1>Authors</h1> - </div> - - - <ul class="list-unstyled"><li> - <p><strong>Johannes Ranke</strong>. Author, maintainer, copyright holder. <a href="https://orcid.org/0000-0003-4371-6538" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> - </p> - </li> - <li> - <p><strong>Katrin Lindenberger</strong>. Contributor. - <br><small>contributed to mkinresplot()</small></p> - </li> - <li> - <p><strong>René Lehmann</strong>. Contributor. - <br><small>ilr() and invilr()</small></p> - </li> - <li> - <p><strong>Eurofins Regulatory AG</strong>. Copyright holder. - <br><small>copyright for some of the contributions of JR 2012-2014</small></p> - </li> - </ul></div> - <div class="section level2 citation-section"> - <div> - <h1 id="citation">Citation</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/DESCRIPTION" class="external-link"><code>DESCRIPTION</code></a></small> - </div> - </div> - - - <p>Ranke J (2023). -<em>mkin: Kinetic Evaluation of Chemical Degradation Data</em>. -R package version 1.2.4, <a href="https://pkgdown.jrwb.de/mkin/">https://pkgdown.jrwb.de/mkin/</a>. -</p> - <pre>@Manual{, - title = {mkin: Kinetic Evaluation of Chemical Degradation Data}, - author = {Johannes Ranke}, - year = {2023}, - note = {R package version 1.2.4}, - url = {https://pkgdown.jrwb.de/mkin/}, -}</pre> - - </div> - -</div> - - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/bootstrap-toc.css b/docs/dev/bootstrap-toc.css deleted file mode 100644 index 5a859415..00000000 --- a/docs/dev/bootstrap-toc.css +++ /dev/null @@ -1,60 +0,0 @@ -/*! 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Includes a function for conveniently defining differential equation - models, model solution based on eigenvalues if possible or using numerical - solvers. If a C compiler (on windows: Rtools) is installed, differential - equation models are solved using automatically generated C functions. - Heteroscedasticity can be taken into account using variance by variable or - two-component error models as described by Ranke and Meinecke (2018) - <doi:10.3390/environments6120124>. Hierarchical degradation models can - be fitted using nonlinear mixed-effects model packages as a back end as - described by Ranke et al. (2021) <doi:10.3390/environments8080071>. 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<span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.4</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"> -<li> - <a href="reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"> -<li> - <a href="articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - 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<a href="articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Performance</li> - <li> - <a href="articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - </li> -<li class="dropdown-header">Miscellaneous</li> - <li> - <a href="articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul> -</li> -<li> - <a href="news/index.html">News</a> -</li> - </ul> -<ul class="nav navbar-nav navbar-right"> -<li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul> -</div> -<!--/.nav-collapse --> - </div> -<!--/.container --> -</div> -<!--/.navbar --> - - - - </header><div class="row"> - <div class="contents col-md-9"> -<div class="section level1"> -<div class="page-header"><h1 id="mkin">mkin<a class="anchor" aria-label="anchor" href="#mkin"></a> -</h1></div> -<p><a href="https://cran.r-project.org/package=mkin" class="external-link"><img src="https://www.r-pkg.org/badges/version/mkin"></a> <a href="https://jranke.r-universe.dev/ui/#package:mkin" class="external-link"><img src="https://jranke.r-universe.dev/badges/mkin" alt="mkin status badge"></a> <a href="https://app.travis-ci.com/github/jranke/mkin" class="external-link"><img src="https://travis-ci.com/jranke/mkin.svg?branch=main" alt="Build Status"></a> <a href="https://app.codecov.io/gh/jranke/mkin" class="external-link"><img src="https://codecov.io/github/jranke/mkin/branch/main/graphs/badge.svg" alt="codecov"></a></p> -<p>The <a href="https://www.r-project.org" class="external-link">R</a> package <strong>mkin</strong> provides calculation routines for the analysis of chemical degradation data, including <b>m</b>ulticompartment <b>kin</b>etics as needed for modelling the formation and decline of transformation products, or if several degradation compartments are involved. It provides stable functionality for kinetic evaluations according to the FOCUS guidance (see below for details). In addition, it provides functionality to do hierarchical kinetics based on nonlinear mixed-effects models.</p> -<div class="section level2"> -<h2 id="installation">Installation<a class="anchor" aria-label="anchor" href="#installation"></a> -</h2> -<p>You can install the latest released version from <a href="https://cran.r-project.org/package=mkin" class="external-link">CRAN</a> from within R:</p> -<div class="sourceCode" id="cb1"><pre class="downlit sourceCode r"> -<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/install.packages.html" class="external-link">install.packages</a></span><span class="op">(</span><span class="st">"mkin"</span><span class="op">)</span></span></code></pre></div> -</div> -<div class="section level2"> -<h2 id="background">Background<a class="anchor" aria-label="anchor" href="#background"></a> -</h2> -<p>In the regulatory evaluation of chemical substances like plant protection products (pesticides), biocides and other chemicals, degradation data play an important role. For the evaluation of pesticide degradation experiments, detailed guidance and various helpful tools have been developed as detailed in ‘Credits and historical remarks’ below. This package aims to provide a one stop solution for degradation kinetics, addressing modellers that are willing to, or even prefer to work with R.</p> -</div> -<div class="section level2"> -<h2 id="basic-usage">Basic usage<a class="anchor" aria-label="anchor" href="#basic-usage"></a> -</h2> -<p>For a start, have a look at the code examples provided for <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mkinfit.html"><code>plot.mkinfit</code></a> and <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mmkin.html"><code>plot.mmkin</code></a>, and at the package vignettes <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_L.html"><code>FOCUS L</code></a> and <a href="https://pkgdown.jrwb.de/mkin/articles/FOCUS_D.html"><code>FOCUS D</code></a>.</p> -</div> -<div class="section level2"> -<h2 id="documentation">Documentation<a class="anchor" aria-label="anchor" href="#documentation"></a> -</h2> -<p>The HTML documentation of the latest version released to CRAN is available at <a href="https://pkgdown.jrwb.de/mkin/">jrwb.de</a> and <a href="https://jranke.github.io/mkin/" class="external-link">github</a>.</p> -<p>Documentation of the development version is found in the <a href="https://pkgdown.jrwb.de/mkin/dev/">‘dev’ subdirectory</a>. In the articles section of this documentation, you can also find demonstrations of the application of nonlinear hierarchical models, also known as nonlinear mixed-effects models, to more complex data, including transformation products and covariates.</p> -</div> -<div class="section level2"> -<h2 id="features">Features<a class="anchor" aria-label="anchor" href="#features"></a> -</h2> -<div class="section level3"> -<h3 id="general">General<a class="anchor" aria-label="anchor" href="#general"></a> -</h3> -<ul> -<li>Highly flexible model specification using <a href="https://pkgdown.jrwb.de/mkin/reference/mkinmod.html"><code>mkinmod</code></a>, including equilibrium reactions and using the single first-order reversible binding (SFORB) model, which will automatically create two state variables for the observed variable.</li> -<li>Model solution (forward modelling) in the function <a href="https://pkgdown.jrwb.de/mkin/reference/mkinpredict.html"><code>mkinpredict</code></a> is performed either using the analytical solution for the case of parent only degradation or some simple models involving a single transformation product, , an eigenvalue based solution if only simple first-order (SFO) or SFORB kinetics are used in the model, or using a numeric solver from the <code>deSolve</code> package (default is <code>lsoda</code>).</li> -<li>The usual one-sided t-test for significant difference from zero is shown based on estimators for the untransformed parameters.</li> -<li>Summary and plotting functions. The <code>summary</code> of an <code>mkinfit</code> object is in fact a full report that should give enough information to be able to approximately reproduce the fit with other tools.</li> -<li>The chi-squared error level as defined in the FOCUS kinetics guidance (see below) is calculated for each observed variable.</li> -<li>The ‘variance by variable’ error model which is often fitted using Iteratively Reweighted Least Squares (IRLS) can be specified as <code>error_model = "obs"</code>.</li> -</ul> -</div> -<div class="section level3"> -<h3 id="unique-in-mkin">Unique in mkin<a class="anchor" aria-label="anchor" href="#unique-in-mkin"></a> -</h3> -<ul> -<li>Three different error models can be selected using the argument <code>error_model</code> to the <a href="https://pkgdown.jrwb.de/mkin/reference/mkinfit.html"><code>mkinfit</code></a> function. A two-component error model similar to the one proposed by <a href="https://pkgdown.jrwb.de/mkin/reference/sigma_twocomp.html">Rocke and Lorenzato</a> can be selected using the argument <code>error_model = "tc"</code>.</li> -<li>Model comparisons using the Akaike Information Criterion (AIC) are supported which can also be used for non-constant variance. In such cases the FOCUS chi-squared error level is not meaningful.</li> -<li>By default, kinetic rate constants and kinetic formation fractions are transformed internally using <a href="https://pkgdown.jrwb.de/mkin/reference/transform_odeparms.html"><code>transform_odeparms</code></a> so their estimators can more reasonably be expected to follow a normal distribution.</li> -<li>When parameter estimates are backtransformed to match the model definition, confidence intervals calculated from standard errors are also backtransformed to the correct scale, and will not include meaningless values like negative rate constants or formation fractions adding up to more than 1, which cannot occur in a single experiment with a single defined radiolabel position.</li> -<li>When a metabolite decline phase is not described well by SFO kinetics, SFORB kinetics can be used for the metabolite. Mathematically, the SFORB model is equivalent to the DFOP model. However, the SFORB model has the advantage that there is a mechanistic interpretation of the model parameters.</li> -<li>Nonlinear mixed-effects models (hierarchical models) can be created from fits of the same degradation model to different datasets for the same compound by using the <a href="https://pkgdown.jrwb.de/mkin/reference/nlme.mmkin.html">nlme.mmkin</a> and <a href="https://pkgdown.jrwb.de/mkin/reference/saem.html">saem.mmkin</a> methods. Note that the convergence of the nlme fits depends on the quality of the data. Convergence is better for simple models and data for many groups (e.g. soils). The saem method uses the <code>saemix</code> package as a backend. Analytical solutions suitable for use with this package have been implemented for parent only models and the most important models including one metabolite (SFO-SFO and DFOP-SFO). Fitting other models with <code>saem.mmkin</code>, while it makes use of the compiled ODE models that mkin provides, has longer run times (from a couple of minutes to more than an hour).</li> -</ul> -</div> -<div class="section level3"> -<h3 id="performance">Performance<a class="anchor" aria-label="anchor" href="#performance"></a> -</h3> -<ul> -<li>Parallel fitting of several models to several datasets is supported, see for example <a href="https://pkgdown.jrwb.de/mkin/reference/plot.mmkin.html"><code>plot.mmkin</code></a>.</li> -<li>If a C compiler is installed, the kinetic models are compiled from automatically generated C code, see <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/compiled_models.html">vignette <code>compiled_models</code></a>. The autogeneration of C code was inspired by the <a href="https://github.com/karlines/ccSolve" class="external-link"><code>ccSolve</code></a> package. Thanks to Karline Soetaert for her work on that.</li> -<li>Even if no compiler is installed, many degradation models still give <a href="https://pkgdown.jrwb.de/mkin/articles/web_only/benchmarks.html">very good performance</a>, as current versions of mkin also have <a href="https://jrwb.de/performance-improvements-mkin/" class="external-link">analytical solutions for some models with one metabolite</a>, and if SFO or SFORB are used for the parent compound, Eigenvalue based solutions of the degradation model are available.</li> -</ul> -</div> -</div> -<div class="section level2"> -<h2 id="gui">GUI<a class="anchor" aria-label="anchor" href="#gui"></a> -</h2> -<p>There is a graphical user interface that may be useful. Please refer to its <a href="https://pkgdown.jrwb.de/gmkin/" class="external-link">documentation page</a> for installation instructions and a manual. It only supports evaluations using (generalised) nonlinear regression, but not simultaneous fits using nonlinear mixed-effects models.</p> -</div> -<div class="section level2"> -<h2 id="news">News<a class="anchor" aria-label="anchor" href="#news"></a> -</h2> -<p>There is a list of changes for the latest <a href="https://cran.r-project.org/package=mkin/news/news.html" class="external-link">CRAN release</a> and one for each github branch, e.g. <a href="https://github.com/jranke/mkin/blob/main/NEWS.md" class="external-link">the main branch</a>.</p> -</div> -<div class="section level2"> -<h2 id="credits-and-historical-remarks">Credits and historical remarks<a class="anchor" aria-label="anchor" href="#credits-and-historical-remarks"></a> -</h2> -<p><code>mkin</code> would not be possible without the underlying software stack consisting of, among others, R and the package <a href="https://cran.r-project.org/package=deSolve" class="external-link">deSolve</a>. In previous version, <code>mkin</code> was also using the functionality of the <a href="https://cran.r-project.org/package=FME" class="external-link">FME</a> package. Please refer to the <a href="https://cran.r-project.org/package=mkin" class="external-link">package page on CRAN</a> for the full list of imported and suggested R packages. Also, <a href="https://debian.org" class="external-link">Debian Linux</a>, the vim editor and the <a href="https://github.com/jalvesaq/Nvim-R" class="external-link">Nvim-R</a> plugin have been invaluable in its development.</p> -<p><code>mkin</code> could not have been written without me being introduced to regulatory fate modelling of pesticides by Adrian Gurney during my time at Harlan Laboratories Ltd (formerly RCC Ltd). <code>mkin</code> greatly profits from and largely follows the work done by the <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">FOCUS Degradation Kinetics Workgroup</a>, as detailed in their guidance document from 2006, slightly updated in 2011 and in 2014.</p> -<p>Also, it was inspired by the first version of KinGUI developed by BayerCropScience, which is based on the MatLab runtime environment.</p> -<p>The companion package <a href="http://kinfit.r-forge.r-project.org/kinfit_static/index.html" class="external-link">kinfit</a> (now deprecated) was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=2" class="external-link">started in 2008</a> and <a href="https://cran.r-project.org/src/contrib/Archive/kinfit/" class="external-link">first published</a> on CRAN on 01 May 2010.</p> -<p>The first <code>mkin</code> code was <a href="https://r-forge.r-project.org/scm/viewvc.php?view=rev&root=kinfit&revision=8" class="external-link">published on 11 May 2010</a> and the <a href="https://cran.r-project.org/src/contrib/Archive/mkin/" class="external-link">first CRAN version</a> on 18 May 2010.</p> -<p>In 2011, Bayer Crop Science started to distribute an R based successor to KinGUI named KinGUII whose R code is based on <code>mkin</code>, but which added, among other refinements, a closed source graphical user interface (GUI), iteratively reweighted least squares (IRLS) optimisation of the variance for each of the observed variables, and Markov Chain Monte Carlo (MCMC) simulation functionality, similar to what is available e.g. in the <code>FME</code> package.</p> -<p>Somewhat in parallel, Syngenta has sponsored the development of an <code>mkin</code> and KinGUII based GUI application called CAKE, which also adds IRLS and MCMC, is more limited in the model formulation, but puts more weight on usability. CAKE is available for download from the <a href="https://cake-kinetics.org" class="external-link">CAKE website</a>, where you can also find a zip archive of the R scripts derived from <code>mkin</code>, published under the GPL license.</p> -<p>Finally, there is <a href="https://github.com/zhenglei-gao/KineticEval" class="external-link">KineticEval</a>, which contains some further development of the scripts used for KinGUII.</p> -<p>Thanks to René Lehmann, formerly working at the Umweltbundesamt, for the nice cooperation on parameter transformations, especially the isometric log-ratio transformation that is now used for formation fractions in case there are more than two transformation targets.</p> -<p>Many inspirations for improvements of mkin resulted from doing kinetic evaluations of degradation data for my clients while working at Harlan Laboratories and at Eurofins Regulatory AG, and now as an independent consultant.</p> -<p>Funding was received from the Umweltbundesamt in the course of the projects</p> -<ul> -<li>Project Number 27452 (Testing and validation of modelling software as an alternative to ModelMaker 4.0, 2014-2015)</li> -<li>Project Number 56703 (Optimization of gmkin for routine use in the Umweltbundesamt, 2015)</li> -<li>Project Number 92570 (Update of Project Number 27452, 2017-2018)</li> -<li>Project Number 112407 (Testing the feasibility of using an error model according to Rocke and Lorenzato for more realistic parameter estimates in the kinetic evaluation of degradation data, 2018-2019)</li> -<li>Project Number 120667 (Development of objective criteria for the evaluation of the visual fit in the kinetic evaluation of degradation data, 2019-2020)</li> -<li>Project Number 146839 (Checking the feasibility of using mixed-effects models for the derivation of kinetic modelling parameters from degradation studies, 2020-2021)</li> -<li>Project Number 173340 (Application of nonlinear hierarchical models to the kinetic evaluation of chemical degradation data)</li> -</ul> -<p>Thanks to everyone involved for collaboration and support!</p> -<p>Thanks are due also to Emmanuelle Comets, maintainer of the saemix package, for her interest and support for using the SAEM algorithm and its implementation in saemix for the evaluation of chemical degradation data.</p> -</div> -<div class="section level2"> -<h2 id="references">References<a class="anchor" aria-label="anchor" href="#references"></a> -</h2> -<table class="table"> -<tr> -<td> -Ranke J, Wöltjen J, Schmidt J, and Comets E (2021) Taking kinetic evaluations of degradation data to the next level with nonlinear mixed-effects models. <i>Environments</i> <b>8</b> (8) 71 <a href="https://doi.org/10.3390/environments8080071" class="external-link">doi:10.3390/environments8080071</a> -</td> -</tr> -<tr> -<td> -Ranke J, Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical Degradation Data <i>Environments</i> <b>6</b> (12) 124 <a href="https://doi.org/10.3390/environments6120124" class="external-link">doi:10.3390/environments6120124</a> -</td> -</tr> -<tr> -<td> -Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic evaluation of chemical degradation data <i>Environmental Sciences Europe</i> <b>30</b> 17 <a href="https://doi.org/10.1186/s12302-018-0145-1" class="external-link">doi:10.1186/s12302-018-0145-1</a> -</td> -</tr> -</table> -</div> -<div class="section level2"> -<h2 id="development">Development<a class="anchor" aria-label="anchor" href="#development"></a> -</h2> -<p>Contributions are welcome!</p> -</div> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <div class="links"> -<h2 data-toc-skip>Links</h2> -<ul class="list-unstyled"> -<li><a href="https://cloud.r-project.org/package=mkin" class="external-link">View on CRAN</a></li> -<li><a href="https://github.com/jranke/mkin/" class="external-link">Browse source code</a></li> -<li><a href="https://github.com/jranke/mkin/issues/" class="external-link">Report a bug</a></li> -</ul> -</div> - -<div class="license"> -<h2 data-toc-skip>License</h2> -<ul class="list-unstyled"> -<li>GPL</li> -</ul> -</div> - - -<div class="citation"> -<h2 data-toc-skip>Citation</h2> -<ul class="list-unstyled"> -<li><a href="authors.html#citation">Citing mkin</a></li> -</ul> -</div> - -<div class="developers"> -<h2 data-toc-skip>Developers</h2> -<ul class="list-unstyled"> -<li>Johannes Ranke <br><small class="roles"> Author, maintainer, copyright holder </small> <a href="https://orcid.org/0000-0003-4371-6538" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a> </li> -<li><a href="authors.html">More about authors...</a></li> -</ul> -</div> - 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- <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1 data-toc-skip>Changelog <small></small></h1> - <small>Source: <a href="https://github.com/jranke/mkin/blob/HEAD/NEWS.md" class="external-link"><code>NEWS.md</code></a></small> - </div> - - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.4" id="mkin-124">mkin 1.2.4<a class="anchor" aria-label="anchor" href="#mkin-124"></a></h2> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.3.1" id="mkin-1231-unreleased">mkin 1.2.3.1 (unreleased)<a class="anchor" aria-label="anchor" href="#mkin-1231-unreleased"></a></h2> -<ul><li>Small fixes to get the online docs right (example code in R/hierarchical_kinetics, cluster setup in cyantraniliprole and dmta pathway vignettes, graphics and model comparison in multistart vignette), rebuild online docs</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.3" id="mkin-123">mkin 1.2.3<a class="anchor" aria-label="anchor" href="#mkin-123"></a></h2> -<ul><li><p>‘R/{endpoints,parms,plot.mixed.mmkin,summary.saem.mmkin}.R’: Calculate parameters and endpoints and plot population curves for specific covariate values, or specific percentiles of covariate values used in saem fits.</p></li> -<li><p>Depend on current deSolve version with the possibility to avoid resolving symbols in a shared library (compiled models) over and over, thanks to Thomas Petzoldt.</p></li> -<li><p>‘inst/rmarkdown/templates/hierarchical_kinetics/skeleton/skeleton.Rmd’: Start a new cluster after creating a model stored in the user specified location, because otherwise symbols are not found by the worker processes.</p></li> -<li><p>‘tests/testthat/test_compiled_symbols.R’: Some new tests to control problems that may have been introduced by the possibility to use pre-resolved symbols.</p></li> -<li><p>‘R/mkinerrmin.R’: Fix typo in subset (use of = instead of ==), thanks to Sebastian Meyer for spotting this during his work on R 4.3.0.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.2" id="mkin-122-unreleased">mkin 1.2.2 (unreleased)<a class="anchor" aria-label="anchor" href="#mkin-122-unreleased"></a></h2> -<ul><li><p>‘inst/rmarkdown/templates/hierarchical_kinetics’: R markdown template to facilitate the application of hierarchical kinetic models.</p></li> -<li><p>‘inst/testdata/{cyantraniliprole_soil_efsa_2014,lambda-cyhalothrin_soil_efsa_2014}.xlsx’: Example spreadsheets for use with ‘read_spreadsheet()’.</p></li> -<li><p>‘R/mhmkin.R’: Allow an ‘illparms.mhmkin’ object or a list with suitable dimensions as value of the argument ‘no_random_effects’, making it possible to exclude random effects that were ill-defined in simpler variants of the set of degradation models. Remove the possibility to exclude random effects based on separate fits, as it did not work well.</p></li> -<li><p>‘R/summary.saem.mmkin.R’: List all initial parameter values in the summary, including random effects and error model parameters. Avoid redundant warnings that occurred in the calculation of correlations of the fixed effects in the case that the Fisher information matrix could not be inverted. List correlations of random effects if specified by the user in the covariance model.</p></li> -<li><p>‘R/parplot.R’: Possibility to select the top ‘llquant’ fraction of the fits for the parameter plots, and improved legend text.</p></li> -<li><p>‘R/illparms.R’: Also check if confidence intervals for slope parameters in covariate models include zero. Only implemented for fits obtained with the saemix backend.</p></li> -<li><p>‘R/parplot.R’: Make the function work also in the case that some of the multistart runs failed.</p></li> -<li><p>‘R/intervals.R’: Include correlations of random effects in the model in case there are any.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.1" id="mkin-121-2022-11-19">mkin 1.2.1 (2022-11-19)<a class="anchor" aria-label="anchor" href="#mkin-121-2022-11-19"></a></h2> -<ul><li><p>‘{data,R}/ds_mixed.rda’: Include the test data in the package instead of generating it in ‘tests/testthat/setup_script.R’. Refactor the generating code to make it consistent and update tests.</p></li> -<li><p>‘tests/testthat/setup_script.R’: Excluded another ill-defined random effect for the DFOP fit with ‘saem’, in an attempt to avoid a platform dependence that surfaced on Fedora systems on the CRAN check farm</p></li> -<li><p>‘tests/testthat/test_mixed.R’: Round parameters found by saemix to two significant digits before printing, to also help to avoid platform dependence of tests</p></li> -<li><p>‘R/saem.R’: Fix a bug that prevented that ‘error.ini’ is passed to ‘saemix_model’, and set default to c(1, 1) to avoid changing test results</p></li> -<li><p>‘R/parplot.R’: Show initial values for error model parameters</p></li> -<li><p>‘R/loglik.mkinfit.R’: Add ‘nobs’ attribute to the resulting ‘logLik’ object, in order to make test_AIC.R succeed on current R-devel</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.2.0" id="mkin-120-2022-11-17">mkin 1.2.0 (2022-11-17)<a class="anchor" aria-label="anchor" href="#mkin-120-2022-11-17"></a></h2> -<ul><li><p>‘R/saem.R’: ‘logLik’, ‘update’ and ‘anova’ methods for ‘saem.mmkin’ objects.</p></li> -<li><p>‘R/saem.R’: Automatic estimation of start parameters for random effects for the case of mkin transformations, nicely improving convergence and reducing problems with iterative ODE solutions.</p></li> -<li><p>‘R/status.R’: New generic to show status information for fit array objects with methods for ‘mmkin’, ‘mhmkin’ and ‘multistart’ objects.</p></li> -<li><p>‘R/mhmkin.R’: New method for performing multiple hierarchical mkin fits in one function call, optionally in parallel.</p></li> -<li><p>‘R/mhmkin.R’: ‘anova.mhmkin’ for conveniently comparing the resulting fits.</p></li> -<li><p>‘R/illparms.R’: New generic to show ill-defined parameters with methods for ‘mkinfit’, ‘mmkin’, ‘saem.mmkin’ and ‘mhmkin’ objects.</p></li> -<li><p>‘R/multistart.R’: New method for testing multiple start parameters for hierarchical model fits, with function ‘llhist’ and new generic ‘parplot’ for diagnostics, and new generics ‘which.best’ and ‘best’ for extracting the fit with the highest likelihood</p></li> -<li><p>‘R/summary.mmkin.R’: Summary method for mmkin objects.</p></li> -<li><p>‘R/saem.R’: Implement and test saemix transformations for FOMC and HS. Also, error out if saemix transformations are requested but not supported.</p></li> -<li><p>‘R/read_spreadsheet.R’: Conveniently read in data from a spreadsheet file.</p></li> -<li><p>‘R/tex_listings.R’: Conveniently include summaries of fit objects in R markdown documents that are compiled to LaTeX.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.1.1" id="mkin-111-2022-07-12">mkin 1.1.1 (2022-07-12)<a class="anchor" aria-label="anchor" href="#mkin-111-2022-07-12"></a></h2> -<ul><li><p>’R/{mkinmod,mkinpredict}.R: Store DLL information in mkinmod objects and use that information in mkinpredict to avoid a performance regression brought by a bugfix in R 4.2.x. Thanks to Tomas Kalibera for his analysis of the problem on the r-package-devel list and his suggestion on how to fix it.</p></li> -<li><p>‘vignettes/FOCUS_L.rmd’: Remove an outdated note referring to a failure to calculate the covariance matrix for DFOP with the L2 dataset. Since 0.9.45.5 the covariance matrix is available</p></li> -<li><p>‘vignettes/web_only/benchmarks.rmd’: Add the first benchmark data using my laptop system, therefore add the CPU when showing the benchmark results.</p></li> -<li><p>‘dimethenamid_2018’: Update example code to use saemix</p></li> -<li><p>‘CAKE_export’: Check for validity of the map argument, updates</p></li> -<li><p>‘saem()’: Slightly improve speed in the case that no analytical solution for saemix is implemented, activate a test of the respective code</p></li> -<li><p>‘mean_degparms’: New argument ‘default_log_parms’ that makes it possible to supply a surrogate value (default) for log parameters that fail the t-test</p></li> -<li><p>‘plot.mixed.mmkin’: Pass the frame argument also to residual plots, take the ‘default_log_parms’ argument for ‘mean_degparms’ used for constructing approximate population curves, plot population curve last to avoid that it is covered by data</p></li> -<li><p>‘plot.mkinfit’: Respect argument ‘maxabs’ for residual plots, and make it possible to give ylim as a list, for row layouts</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.1.0" id="mkin-110-2022-03-14">mkin 1.1.0 (2022-03-14)<a class="anchor" aria-label="anchor" href="#mkin-110-2022-03-14"></a></h2> -<div class="section level3"> -<h3 id="mixed-effects-models-1-1-0">Mixed-effects models<a class="anchor" aria-label="anchor" href="#mixed-effects-models-1-1-0"></a></h3> -<ul><li><p>Reintroduce the interface to saemix version 3.0 (now on CRAN), in particular the generic function ‘saem’ with a generator ‘saem.mmkin’, currently using ‘saemix_model’ and ‘saemix_data’, summary and plot methods</p></li> -<li><p>‘mean_degparms’: New argument ‘test_log_parms’ that makes the function only consider log-transformed parameters where the untransformed parameters pass the t-test for a certain confidence level. This can be used to obtain more plausible starting parameters for the different mixed-effects model backends</p></li> -<li><p>‘plot.mixed.mmkin’: Gains arguments ‘test_log_parms’ and ‘conf.level’</p></li> -<li><p>‘vignettes/web_only/dimethenamid_2018.rmd’: Example evaluations of the dimethenamid data.</p></li> -<li><p>‘intervals’: Provide a method of this nlme function for ‘saem.mmkin’ objects.</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.5" id="mkin-105-2021-09-15">mkin 1.0.5 (2021-09-15)<a class="anchor" aria-label="anchor" href="#mkin-105-2021-09-15"></a></h2> -<ul><li>‘dimethenamid_2018’: Correct the data for the Borstel soil. The five observations from Staudenmaier (2013) that were previously stored as “Borstel 2” are actually just a subset of the 16 observations in “Borstel 1” which is now simply “Borstel”</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.4" id="mkin-104-2021-04-20">mkin 1.0.4 (2021-04-20)<a class="anchor" aria-label="anchor" href="#mkin-104-2021-04-20"></a></h2> -<ul><li><p>All plotting functions setting graphical parameters: Use on.exit() for resetting graphical parameters</p></li> -<li><p>‘plot.mkinfit’: Use xlab and xlim for the residual plot if show_residuals is TRUE</p></li> -<li><p>‘mmkin’: Use cores = 1 per default on Windows to make it easier for first time users</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.3" id="mkin-103-2021-02-15">mkin 1.0.3 (2021-02-15)<a class="anchor" aria-label="anchor" href="#mkin-103-2021-02-15"></a></h2> -<ul><li>Review and update README, the ‘Introduction to mkin’ vignette and some of the help pages</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.2" id="mkin-102-unreleased">mkin 1.0.2 (Unreleased)<a class="anchor" aria-label="anchor" href="#mkin-102-unreleased"></a></h2> -<ul><li>‘mkinfit’: Keep model names stored in ‘mkinmod’ objects, avoiding their loss in ‘gmkin’</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.1" id="mkin-101-2021-02-10">mkin 1.0.1 (2021-02-10)<a class="anchor" aria-label="anchor" href="#mkin-101-2021-02-10"></a></h2> -<ul><li><p>‘confint.mmkin’, ‘nlme.mmkin’, ‘transform_odeparms’: Fix example code in dontrun sections that failed with current defaults</p></li> -<li><p>‘logLik.mkinfit’: Improve example code to avoid warnings and show convenient syntax</p></li> -<li><p>‘mkinresplot’: Re-add Katrin Lindenberger as coauthor who was accidentally removed long ago</p></li> -<li><p>Remove tests relying on non-convergence of the FOMC fit to the FOCUS A dataset as this is platform dependent (revealed by the new additional tests on CRAN, thanks!)</p></li> -<li><p>Increase test tolerance for some parameter comparisons that also proved to be platform dependent</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="1.0.0" id="mkin-100-2021-02-03">mkin 1.0.0 (2021-02-03)<a class="anchor" aria-label="anchor" href="#mkin-100-2021-02-03"></a></h2> -<div class="section level3"> -<h3 id="general-1-0-0">General<a class="anchor" aria-label="anchor" href="#general-1-0-0"></a></h3> -<ul><li><p>‘mkinmod’ models gain arguments ‘name’ and ‘dll_dir’ which, in conjunction with a current version of the ‘inline’ package, make it possible to still use the DLL used for fast ODE solutions with ‘deSolve’ after saving and restoring the ‘mkinmod’ object.</p></li> -<li><p>‘mkindsg’ R6 class for groups of ‘mkinds’ datasets with metadata</p></li> -<li><p>‘f_norm_temp_focus’ generic function to normalise time intervals using the FOCUS method, with methods for numeric vectors and ‘mkindsg’ objects</p></li> -<li><p>‘D24_2014’ and ‘dimethenamid_2018’ datasets</p></li> -<li><p>‘focus_soil_moisture’ FOCUS default soil moisture data</p></li> -<li><p>‘update’ method for ‘mmkin’ objects</p></li> -<li><p>‘transform_odeparms’, ‘backtransform_odeparms’: Use logit transformation for solitary fractions like the g parameter of the DFOP model, or formation fractions for a pathway to only one target variable</p></li> -<li><p>‘plot.mmkin’: Add a ylab argument, making it possible to customize the y axis label of the panels on the left without affecting the residual plots. Reduce legend size and vertical distance between panels</p></li> -<li><p>‘plot.mkinfit’: Change default ylab from “Observed” to “Residue”. Pass xlab to residual plot if show_residuals is TRUE.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="mixed-effects-models-1-0-0">Mixed-effects models<a class="anchor" aria-label="anchor" href="#mixed-effects-models-1-0-0"></a></h3> -<ul><li><p>‘mixed.mmkin’ New container for mmkin objects for plotting with the ‘plot.mixed.mmkin’ method</p></li> -<li><p>‘plot.mixed.mmkin’ method used for ‘nlme.mmkin’ inheriting from ‘mixed.mmkin’ (currently virtual)</p></li> -<li><p>‘plot’, ‘summary’ and ‘print’ methods for ‘nlme.mmkin’ objects</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.50.3" id="mkin-09503-2020-10-08">mkin 0.9.50.3 (2020-10-08)<a class="anchor" aria-label="anchor" href="#mkin-09503-2020-10-08"></a></h2> -<ul><li><p>‘parms’: Add a method for mmkin objects</p></li> -<li><p>‘mmkin’ and ‘confint(method = ’profile’): Use all cores detected by parallel::detectCores() per default</p></li> -<li><p>‘confint(method = ’profile’): Choose accuracy based on ‘rel_tol’ argument, relative to the bounds obtained by the quadratic approximation</p></li> -<li><p>‘mkinfit’: Make ‘use_of_ff’ = “max” also the default for models specified using short names like “SFO” or “FOMC”</p></li> -<li><p>‘mkinfit’: Run ‘stats::shapiro.test()’ on standardized residuals and warn if p < 0.05</p></li> -<li><p>‘mkinfit’: ‘error_model_algorithm’ = ‘d_3’ does not fail if direct fitting fails, but reports that the results for the threestep algorithm are returned</p></li> -<li><p>‘mmkin’: Do not fail any more if one of the fits fails, but assign the try-error to the respective position in the mmkin object</p></li> -<li><p>‘mkinfit’: Ignore components of state.ini that do not correspond to state variables in the model</p></li> -<li><p>‘endpoints’: Back-calculate DT50 value from DT90 also for the biphasic models DFOP, HS and SFORB</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.50.2" id="mkin-09502-2020-05-12">mkin 0.9.50.2 (2020-05-12)<a class="anchor" aria-label="anchor" href="#mkin-09502-2020-05-12"></a></h2> -<ul><li><p>Increase tolerance for a platform specific test results on the Solaris test machine on CRAN</p></li> -<li><p>Updates and corrections (using the spelling package) to the documentation</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.50.1" id="mkin-09501-2020-05-11">mkin 0.9.50.1 (2020-05-11)<a class="anchor" aria-label="anchor" href="#mkin-09501-2020-05-11"></a></h2> -<ul><li><p>Support SFORB with formation fractions</p></li> -<li><p>‘mkinmod’: Make ‘use_of_ff’ = “max” the default</p></li> -<li><p>Improve performance by a) avoiding expensive calls in the cost function like merge() and data.frame(), and b) by implementing analytical solutions for SFO-SFO and DFOP-SFO</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.11" id="mkin-094911-2020-04-20">mkin 0.9.49.11 (2020-04-20)<a class="anchor" aria-label="anchor" href="#mkin-094911-2020-04-20"></a></h2> -<ul><li>Increase a test tolerance to make it pass on all CRAN check machines</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.10" id="mkin-094910-2020-04-18">mkin 0.9.49.10 (2020-04-18)<a class="anchor" aria-label="anchor" href="#mkin-094910-2020-04-18"></a></h2> -<ul><li><p>‘nlme.mmkin’: An nlme method for mmkin row objects and an associated S3 class with print, plot, anova and endpoint methods</p></li> -<li><p>‘mean_degparms, nlme_data, nlme_function’: Three new functions to facilitate building nlme models from mmkin row objects</p></li> -<li><p>‘endpoints’: Don’t return the SFORB list component if it’s empty. This reduces distraction and complies with the documentation</p></li> -<li><p>Article in compiled models: Add some platform specific code and suppress warnings about zero values being removed from the FOCUS D dataset</p></li> -<li><p>‘plot.mmkin’: Add the argument ‘standardized’ to avoid warnings that occurred when it was passed as part of the additional arguments captured by the dots (…)</p></li> -<li><p>‘summary.mkinfit’: Add AIC, BIC and log likelihood to the summary</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.9" id="mkin-09499-2020-03-31">mkin 0.9.49.9 (2020-03-31)<a class="anchor" aria-label="anchor" href="#mkin-09499-2020-03-31"></a></h2> -<ul><li><p>‘mkinmod’: Use pkgbuild::has_compiler instead of Sys.which(‘gcc’), as the latter will often fail even if Rtools are installed</p></li> -<li><p>‘mkinds’: Use roxygen for documenting fields and methods of this R6 class</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.8" id="mkin-09498-2020-01-09">mkin 0.9.49.8 (2020-01-09)<a class="anchor" aria-label="anchor" href="#mkin-09498-2020-01-09"></a></h2> -<ul><li><p>‘aw’: Generic function for calculating Akaike weights, methods for mkinfit objects and mmkin columns</p></li> -<li><p>‘loftest’: Add a lack-of-fit test</p></li> -<li><p>‘plot_res’, ‘plot_sep’ and ‘mkinerrplot’: Add the possibility to show standardized residuals and make it the default for fits with error models other than ‘const’</p></li> -<li><p>‘lrtest.mkinfit’: Improve naming of the compared fits in the case of fixed parameters</p></li> -<li><p>‘confint.mkinfit’: Make the quadratic approximation the default, as the likelihood profiling takes a lot of time, especially if the fit has more than three parameters</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.7" id="mkin-09497-2019-11-01">mkin 0.9.49.7 (2019-11-01)<a class="anchor" aria-label="anchor" href="#mkin-09497-2019-11-01"></a></h2> -<ul><li><p>Fix a bug introduced in 0.9.49.6 that occurred if the direct optimisation yielded a higher likelihood than the three-step optimisation in the d_3 algorithm, which caused the fitted parameters of the three-step optimisation to be returned instead of the parameters of the direct optimisation</p></li> -<li><p>Add a ‘nobs’ method for mkinfit objects, enabling the default ‘BIC’ method from the stats package. Also, add a ‘BIC’ method for mmkin column objects.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.6" id="mkin-09496-2019-10-31">mkin 0.9.49.6 (2019-10-31)<a class="anchor" aria-label="anchor" href="#mkin-09496-2019-10-31"></a></h2> -<ul><li><p>Implement a likelihood ratio test as a method for ‘lrtest’ from the lmtest package</p></li> -<li><p>Add an ‘update’ method for mkinfit objects which remembers fitted parameters if appropriate</p></li> -<li><p>Add a ‘residuals’ method for mkinfit objects that supports scaling based on the error model</p></li> -<li><p>Fix a bug in ‘mkinfit’ that prevented summaries of objects fitted with fixed parameters to be generated</p></li> -<li><p>Add ‘parms’ and ‘confint’ methods for mkinfit objects. Confidence intervals based on the quadratic approximation as in the summary, and based on the profile likelihood</p></li> -<li><p>Move long-running tests to tests/testthat/slow with a separate test log. They currently take around 7 minutes on my system</p></li> -<li><p>‘mkinfit’: Clean the code and return functions to calculate the log-likelihood and the sum of squared residuals</p></li> -<li><p>Vignette ‘twa.html’: Add the maximum time weighted average formulas for the hockey stick model</p></li> -<li><p>Support frameless plots (‘frame = FALSE’)</p></li> -<li><p>Support to suppress the chi2 error level (‘show_errmin = FALSE’) in ‘plot.mmkin’</p></li> -<li><p>Update README and the introductory vignette</p></li> -<li><p>Report ‘OLS’ as error_model_algorithm in the summary in the case that the default error_model (‘const’) is used</p></li> -<li><p>Support summarizing ‘mkinfit’ objects generated with versions < 0.9.49.5</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.49.5" id="mkin-09495-2019-07-04">mkin 0.9.49.5 (2019-07-04)<a class="anchor" aria-label="anchor" href="#mkin-09495-2019-07-04"></a></h2> -<ul><li><p>Several algorithms for minimization of the negative log-likelihood for non-constant error models (two-component and variance by variable). In the case the error model is constant variance, least squares is used as this is more stable. The default algorithm ‘d_3’ tries direct minimization and a three-step procedure, and returns the model with the highest likelihood.</p></li> -<li><p>The argument ‘reweight.method’ to mkinfit and mmkin is now obsolete, use ‘error_model’ and ‘error_model_algorithm’ instead</p></li> -<li><p>Add a test that checks if we get the best known AIC for parent only fits to 12 test datasets. Add these test datasets for this purpose.</p></li> -<li><p>New function ‘mkinerrplot’. This function is also used for residual plots in ‘plot.mmkin’ if the argument ‘resplot = “errmod”’ is given, and in ‘plot.mkinfit’ if ‘show_errplot’ is set to TRUE.</p></li> -<li><p>Remove dependency on FME, only use nlminb for optimisation (‘Port’ algorithm). I cannot remember cases where one of the other optimisation algorithms was preferable, except that I sometime used Levenberg-Marquardt for speed in cases where I did not expect to get trapped in a local minimum.</p></li> -<li><p>Use the numDeriv package to calculate hessians. This results in slightly different confidence intervals, takes a bit longer, but is apparently more robust</p></li> -<li><p>Add a simple benchmark vignette to document the impact on performance.</p></li> -<li><p>The code for manual weighting was removed. This functionality might get added again at a later time. For the time being, please use an earlier version, e.g. 0.9.48.1 if you want to do manual weighting.</p></li> -<li><p>The fitting time reported in the summary now includes the time used for calculation of the hessians</p></li> -<li><p>Adapt tests</p></li> -<li><p>Fix an error in the FOCUS chi2 error level calculations that occurred if parameters were specified in parms.ini that were not in the model. A warning was already issued, but when fitting in parallel via mmkin this could go unnoticed.</p></li> -<li><p>Add example datasets obtained from risk assessment reports published by the European Food Safety Agency.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.48.1" id="mkin-09481-2019-03-04">mkin 0.9.48.1 (2019-03-04)<a class="anchor" aria-label="anchor" href="#mkin-09481-2019-03-04"></a></h2> -<ul><li><p>Add the function ‘logLik.mkinfit’ which makes it possible to calculate an AIC for mkinfit objects</p></li> -<li><p>Add the function ‘AIC.mmkin’ to make it easy to compare columns of mmkin objects</p></li> -<li><p>‘add_err’: Respect the argument giving the number of replicates in the synthetic dataset</p></li> -<li><p>‘max_twa_parent’: Support maximum time weighted average concentration calculations for the hockey stick (HS) model</p></li> -<li><p>‘mkinpredict’: Make the function generic and create a method for mkinfit objects</p></li> -<li><p>‘mkinfit’: Improve the correctness of the fitted two component error model by fitting the mean absolute deviance at each observation against the observed values, weighting with the current two-component error model</p></li> -<li><p>‘tests/testthat/test_irls.R’: Test if the components of the error model used to generate the data can be reproduced with moderate accuracy</p></li> -<li><p>Add the function ‘CAKE_export’ to facilitate cross-checking of results</p></li> -<li><p>Implement the logistic model (only tested for parent fits)</p></li> -<li><p>‘nafta’: Add evaluations according to the NAFTA guidance</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.47.5" id="mkin-09475-2018-09-14">mkin 0.9.47.5 (2018-09-14)<a class="anchor" aria-label="anchor" href="#mkin-09475-2018-09-14"></a></h2> -<ul><li><p>Make the two-component error model stop in cases where it is inadequate to avoid nls crashes on windows</p></li> -<li><p>Move two vignettes to a location where they will not be built on CRAN (to avoid more NOTES from long execution times)</p></li> -<li><p>Exclude more example code from testing on CRAN to avoid NOTES from long execution times</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.47.3" id="mkin-09473">mkin 0.9.47.3<a class="anchor" aria-label="anchor" href="#mkin-09473"></a></h2> -<ul><li><p>‘mkinfit’: Improve fitting the error model for reweight.method = ‘tc’. Add ‘manual’ to possible arguments for ‘weight’</p></li> -<li><p>Test that FOCUS_2006_C can be evaluated with DFOP and reweight.method = ‘tc’</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.47.2" id="mkin-09472-2018-07-19">mkin 0.9.47.2 (2018-07-19)<a class="anchor" aria-label="anchor" href="#mkin-09472-2018-07-19"></a></h2> -<ul><li><p>‘sigma_twocomp’: Rename ‘sigma_rl’ to ‘sigma_twocomp’ as the Rocke and Lorenzato model assumes lognormal distribution for large y. Correct references to the Rocke and Lorenzato model accordingly.</p></li> -<li><p>‘mkinfit’: Use 1.1 as starting value for N parameter of IORE models to obtain convergence in more difficult cases. Show parameter names when ‘trace_parms’ is ‘TRUE’.</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.47.1" id="mkin-09471-2018-02-06">mkin 0.9.47.1 (2018-02-06)<a class="anchor" aria-label="anchor" href="#mkin-09471-2018-02-06"></a></h2> -<ul><li><p>Skip some tests on CRAN and winbuilder to avoid timeouts</p></li> -<li><p>‘test_data_from_UBA_2014’: Added this list of datasets containing experimental data used in the expertise from 2014</p></li> -<li><p>‘mkinfit’: Added the iterative reweighting method ‘tc’ using the two-component error model from Rocke and Lorenzato. NA values in the data are not returned any more.</p></li> -<li><p>‘mkinfit’: Work around a bug in the current FME version that prevented the convergence message to be returned in the case of non-convergence.</p></li> -<li><p>‘summary.mkinfit’: Improved output regarding weighting method. No predictions are returned for NA values in the model (see above).</p></li> -<li><p>‘summary.mkinfit’: Show versions of mkin and R used for fitting (not the ones used for the summary) if the fit was generated with mkin >= 0.9.47.1</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.46.3" id="mkin-09463-2017-11-16">mkin 0.9.46.3 (2017-11-16)<a class="anchor" aria-label="anchor" href="#mkin-09463-2017-11-16"></a></h2> -<ul><li><p><code>README.md</code>, <code>vignettes/mkin.Rmd</code>: URLs were updated</p></li> -<li><p><code>synthetic_data_for_UBA</code>: Add the code used to generate the data in the interest of reproducibility</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.46.2" id="mkin-09462-2017-10-10">mkin 0.9.46.2 (2017-10-10)<a class="anchor" aria-label="anchor" href="#mkin-09462-2017-10-10"></a></h2> -<ul><li><p>Converted the vignette FOCUS_Z from tex/pdf to markdown/html</p></li> -<li><p><code>DESCRIPTION</code>: Add ORCID</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.46.1" id="mkin-09461-2017-09-14">mkin 0.9.46.1 (2017-09-14)<a class="anchor" aria-label="anchor" href="#mkin-09461-2017-09-14"></a></h2> -<ul><li><p><code>plot.mkinfit</code>: Fix scaling of residual plots for the case of separate plots for each observed variable</p></li> -<li><p><code>plot.mkinfit</code>: Use all data points of the fitted curve for y axis scaling for the case of separate plots for each observed variable</p></li> -<li><p>Documentation updates</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.46" id="mkin-0946-2017-07-24">mkin 0.9.46 (2017-07-24)<a class="anchor" aria-label="anchor" href="#mkin-0946-2017-07-24"></a></h2> -<ul><li>Remove <code>test_FOMC_ill-defined.R</code> as it is too platform dependent</li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.45.2" id="mkin-09452-2017-07-24">mkin 0.9.45.2 (2017-07-24)<a class="anchor" aria-label="anchor" href="#mkin-09452-2017-07-24"></a></h2> -<ul><li><p>Rename <code>twa</code> to <code>max_twa_parent</code> to avoid conflict with <code>twa</code> from my <code>pfm</code> package</p></li> -<li><p>Update URLs in documentation</p></li> -<li><p>Limit test code to one core to pass on windows</p></li> -<li><p>Switch from <code>microbenchmark</code> to <code>rbenchmark</code> as the former is not supported on all platforms</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.45.1" id="mkin-09451-2016-12-20">mkin 0.9.45.1 (2016-12-20)<a class="anchor" aria-label="anchor" href="#mkin-09451-2016-12-20"></a></h2> -<div class="section level3"> -<h3 id="new-features-0-9-45-1">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-45-1"></a></h3> -<ul><li>A <code>twa</code> function, calculating maximum time weighted average concentrations for the parent (SFO, FOMC and DFOP).</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.45" id="mkin-0945-2016-12-08">mkin 0.9.45 (2016-12-08)<a class="anchor" aria-label="anchor" href="#mkin-0945-2016-12-08"></a></h2> -<div class="section level3"> -<h3 id="minor-changes-0-9-45">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-45"></a></h3> -<ul><li><p><code>plot.mkinfit</code> and <code>plot.mmkin</code>: If the plotting device is <code>tikz</code>, LaTeX markup is being used for the chi2 error in the graphs.</p></li> -<li><p>Use <code>pkgdown</code>, the successor of <code>staticdocs</code> for generating static HTML documentation. Include example output and graphs also for <code>dontrun</code> sections.</p></li> -<li><p><code>plot.mkinfit</code>: Plotting does not fail any more when the compiled model is not available, e.g. because it was removed from the temporary directory. In this case, the uncompiled model is now used for plotting</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.44" id="mkin-0944-2016-06-29">mkin 0.9.44 (2016-06-29)<a class="anchor" aria-label="anchor" href="#mkin-0944-2016-06-29"></a></h2> -<div class="section level3"> -<h3 id="bug-fixes-0-9-44">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-44"></a></h3> -<ul><li>The test <code>test_FOMC_ill-defined</code> failed on several architectures, so the test is now skipped</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.43" id="mkin-0943-2016-06-28">mkin 0.9.43 (2016-06-28)<a class="anchor" aria-label="anchor" href="#mkin-0943-2016-06-28"></a></h2> -<div class="section level3"> -<h3 id="major-changes-0-9-43">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-43"></a></h3> -<ul><li><p>The title was changed to <code>Kinetic evaluations of chemical degradation data</code></p></li> -<li><p><code>plot.mkinfit</code>: Add the possibility to show fits (and residual plots if requested) separately for the observed variables</p></li> -<li><p><code>plot.mkinfit</code>: Add the possibility to show the chi2 error levels in the plot, similar to the way they are shown in <code>plot.mmkin</code></p></li> -<li><p><code>plot_sep</code>: Add this function as a convenience wrapper for plotting observed variables of mkinfit objects separately, with chi2 error values and residual plots.</p></li> -<li><p>Vignettes: The main vignette <code>mkin</code> was converted to R markdown and updated. The other vignettes were also updated to show current improved functionality.</p></li> -<li><p>The function <code>add_err</code> was added to the package, making it easy to generate simulated data using an error model based on the normal distribution</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-43">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-43"></a></h3> -<ul><li><p>Remove an outdated reference to the inline package in the <code>compiled_models</code> vignette</p></li> -<li><p><code>mkinfit</code>: Do not error out in cases where the fit converges, but the Jacobian for the untransformed model cost can not be estimated. Give a warning instead and return NA for the t-test results.</p></li> -<li><p><code>summary.mkinfit</code>: Give a warning message when the covariance matrix can not be obtained.</p></li> -<li><p>A test has been added to containing a corresponding edge case to check that the warnings are correctly issued and the fit does not terminate.</p></li> -<li><p><code>plot.mmkin</code>: Round the chi2 error value to three significant digits, instead of two decimal digits.</p></li> -<li><p><code>mkinfit</code>: Return the <code>err</code> values used on weighted fits as a column named <code>err</code>. Also include these inverse weights when the column <code>value</code> in the observed data is used, which is returned as <code>observed</code> in the data component of the mkinfit object.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-43">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-43"></a></h3> -<ul><li><p><code>endpoints</code>: When the name of a substance degrading to a metabolite (e.g. a parent compound) used in the model formulation ended in the letter <code>f</code>, some rate parameters could be listed as formation fractions with mixed up names. These would also appear in the summary.</p></li> -<li><p><code>mkinfit</code>: Check for all observed variables when checking if the user tried to fix formation fractions when fitting them using ilr transformation.</p></li> -<li><p><code>plot.mmkin</code>: Set the plot margins correctly, also in the case of a single fit to be plotted, so the main title is placed in a reasonable way.</p></li> -<li><p><code>plot.mkinfit</code>: Correct default values for <code>col_obs</code>, <code>pch_obs</code> and <code>lty_obs</code> for the case that <code>obs_vars</code> is specified.</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9.42" id="mkin-0942-2016-03-25">mkin 0.9.42 (2016-03-25)<a class="anchor" aria-label="anchor" href="#mkin-0942-2016-03-25"></a></h2> -<div class="section level3"> -<h3 id="major-changes-0-9-42">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-42"></a></h3> -<ul><li>Add the argument <code>from_max_mean</code> to <code>mkinfit</code>, for fitting only the decline from the maximum observed value for models with a single observed variable</li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-42">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-42"></a></h3> -<ul><li><p>Add plots to <code>compiled_models</code> vignette</p></li> -<li><p>Give an explanatory error message when mkinmod fails due to a missing definition of a target variable</p></li> -<li><p><code><a href="../reference/mkinmod.html">print.mkinmod()</a></code>: Improve formatting when printing mkinmod model definitions</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-41" id="mkin-09-41-2015-11-09">mkin 0.9-41 (2015-11-09)<a class="anchor" aria-label="anchor" href="#mkin-09-41-2015-11-09"></a></h2> -<div class="section level3"> -<h3 id="minor-changes-0-9-41">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-41"></a></h3> -<ul><li><p>Add an R6 class <code>mkinds</code> representing datasets with a printing method</p></li> -<li><p>Add a printing method for mkinmod objects</p></li> -<li><p>Make it possible to specify arbitrary strings as names for the compounds in <code>mkinmod</code>, and show them in the plot</p></li> -<li><p>Use an index.r file to group help topics in static documentation</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-41">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-41"></a></h3> -<ul><li> -<code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Avoid an error that occurred when printing summaries generated with mkin versions before 0.9-36</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-40" id="mkin-09-40-2015-07-21">mkin 0.9-40 (2015-07-21)<a class="anchor" aria-label="anchor" href="#mkin-09-40-2015-07-21"></a></h2> -<div class="section level3"> -<h3 id="bug-fixes-0-9-40">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-40"></a></h3> -<ul><li> -<code><a href="../reference/endpoints.html">endpoints()</a></code>: For DFOP and SFORB models, where <code><a href="https://rdrr.io/r/stats/optimize.html" class="external-link">optimize()</a></code> is used, make use of the fact that the DT50 must be between DT50_k1 and DT50_k2 (DFOP) or DT50_b1 and DT50_b2 (SFORB), as <code><a href="https://rdrr.io/r/stats/optimize.html" class="external-link">optimize()</a></code> sometimes did not find the minimum. Likewise for finding DT90 values. Also fit on the log scale to make the function more efficient.</li> -</ul></div> -<div class="section level3"> -<h3 id="internal-changes-0-9-40">Internal changes<a class="anchor" aria-label="anchor" href="#internal-changes-0-9-40"></a></h3> -<ul><li> -<code>DESCRIPTION</code>, <code>NAMESPACE</code>, <code>R/*.R</code>: Import (from) stats, graphics and methods packages, and qualify some function calls for non-base packages installed with R to avoid NOTES made by R CMD check –as-cran with upcoming R versions.</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-39" id="mkin-09-39-2015-06-26">mkin 0.9-39 (2015-06-26)<a class="anchor" aria-label="anchor" href="#mkin-09-39-2015-06-26"></a></h2> -<div class="section level3"> -<h3 id="major-changes-0-9-39">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-39"></a></h3> -<ul><li><p>New function <code><a href="../reference/mmkin.html">mmkin()</a></code>: This function takes a character vector of model shorthand names, or alternatively a list of mkinmod models, as well as a list of dataset as main arguments. It returns a matrix of mkinfit objects, with a row for each model and a column for each dataset. A subsetting method with single brackets is available. Fitting the models in parallel using the <code>parallel</code> package is supported.</p></li> -<li><p>New function <code><a href="../reference/plot.mmkin.html">plot.mmkin()</a></code>: Plots single-row or single-column <code>mmkin</code> objects including residual plots.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-39">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-39"></a></h3> -<ul><li> -<code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Fix the x axis scaling for rate constants and formation fractions that got confused by the introduction of the t-values of transformed parameters.</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-38" id="mkin-09-38-2015-06-24">mkin 0.9-38 (2015-06-24)<a class="anchor" aria-label="anchor" href="#mkin-09-38-2015-06-24"></a></h2> -<div class="section level3"> -<h3 id="minor-changes-0-9-38">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-38"></a></h3> -<ul><li><p><code>vignettes/compiled_models.html</code>: Show the performance improvement factor actually obtained when building the vignette, as well as mkin version, some system info and the CPU model used for building the vignette.</p></li> -<li><p><code>GNUMakefile</code>,<code>vignettes/*</code>: Clean up vignette generation and include table of contents in HTML vignettes.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-38">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-38"></a></h3> -<ul><li> -<code><a href="../reference/mkinmod.html">mkinmod()</a></code>: When generating the C code for the derivatives, only declare the time variable when it is needed and remove the ‘-W-no-unused-variable’ compiler flag as the C compiler used in the CRAN checks on Solaris does not know it.</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-36" id="mkin-09-36-2015-06-21">mkin 0.9-36 (2015-06-21)<a class="anchor" aria-label="anchor" href="#mkin-09-36-2015-06-21"></a></h2> -<div class="section level3"> -<h3 id="major-changes-0-9-36">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-36"></a></h3> -<ul><li><p><code><a href="../reference/summary.mkinfit.html">summary.mkinfit()</a></code>: A one-sided t-test for significant difference of untransformed parameters from zero is now always shown, based on the assumption of normal distribution for estimators of all untransformed parameters. Use with caution, as this assumption is unrealistic e.g. for rate constants in these nonlinear kinetic models.</p></li> -<li><p>If a compiler (gcc) is installed, use a version of the differential equation model compiled from C code, which is a huge performance boost for models where only the deSolve method works.</p></li> -<li><p><code><a href="../reference/mkinmod.html">mkinmod()</a></code>: Create a list component $cf (of class CFuncList) in the list returned by mkinmod, if a version can be compiled from autogenerated C code (see above).</p></li> -<li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Set the default <code>solution_type</code> to <code>deSolve</code> when a compiled version of the model is present, except when an analytical solution is possible.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-36">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-36"></a></h3> -<ul><li>Added a simple showcase vignette with an evaluation of FOCUS example dataset D</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-35" id="mkin-09-35-2015-05-15">mkin 0.9-35 (2015-05-15)<a class="anchor" aria-label="anchor" href="#mkin-09-35-2015-05-15"></a></h2> -<div class="section level3"> -<h3 id="major-changes-0-9-35">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-35"></a></h3> -<ul><li>Switch from RUnit to testthat for testing</li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-35">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-35"></a></h3> -<ul><li><p><code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Avoid warnings that occurred when not all confidence intervals were available in the summary of the fit</p></li> -<li><p><code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Fix printing the summary for the case that the number of iterations is not available</p></li> -<li><p>NAMESPACE: export S3 methods plot.mkinfit, summary.mkinfit and print.summary.mkinfit to satisfy R CMD check on R-devel</p></li> -<li><p><code><a href="../reference/mkinparplot.html">mkinparplot()</a></code>: Avoid warning in R CMD check about undeclared global variable <code>Lower</code></p></li> -</ul></div> -<div class="section level3"> -<h3 id="new-features-0-9-35">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-35"></a></h3> -<ul><li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Report successful termination when quiet = FALSE. This is helpful for more difficult problems fitted with reweight.method = obs, as no progress is often indicated during the reweighting.</p></li> -<li><p>A first test using results established in the expertise written for the German Federal Environmental Agency (UBA) was added.</p></li> -<li><p>Add synthetic datasets generated for expertise written for the German Federal Environmental Agency UBA</p></li> -<li><p>Add tests based on these datasets</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-34" id="mkin-09-34-2014-11-22">mkin 0.9-34 (2014-11-22)<a class="anchor" aria-label="anchor" href="#mkin-09-34-2014-11-22"></a></h2> -<div class="section level3"> -<h3 id="new-features-0-9-34">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-34"></a></h3> -<ul><li><p>Add the convenience function <code><a href="../reference/mkinmod.html">mkinsub()</a></code> for creating the lists used in <code><a href="../reference/mkinmod.html">mkinmod()</a></code></p></li> -<li><p>Add the possibility to fit indeterminate order rate equation (IORE) models using an analytical solution (parent only) or a numeric solution. Paths from IORE compounds to metabolites are supported when using formation fractions (use_of_ff = ‘max’). Note that the numerical solution (method.ode = ‘deSolve’) of the IORE differential equations sometimes fails due to numerical problems.</p></li> -<li><p>Switch to using the Port algorithm (using a model/trust region approach) per default. While needing more iterations than the Levenberg-Marquardt algorithm previously used per default, it is less sensitive to starting parameters.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-34">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-34"></a></h3> -<ul><li><p>The formatting of differential equations in the summary was further improved</p></li> -<li><p>Always include 0 on y axis when plotting during the fit</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-33" id="mkin-09-33-2014-10-22">mkin 0.9-33 (2014-10-22)<a class="anchor" aria-label="anchor" href="#mkin-09-33-2014-10-22"></a></h2> -<div class="section level3"> -<h3 id="new-features-0-9-33">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-33"></a></h3> -<ul><li><p>The initial value (state.ini) for the observed variable with the highest observed residue is set to 100 in case it has no time zero observation and <code>state.ini = "auto"</code></p></li> -<li><p>A basic unit test for <code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code> was written</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-33">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-33"></a></h3> -<ul><li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: The internally fitted parameter for <code>g</code> was named <code>g_ilr</code> even when <code>transform_fractions=FALSE</code></p></li> -<li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: The initial value (state.ini) for the parent compound was not set when the parent was not the (only) variable with the highest value in the observed data.</p></li> -<li><p><code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code>: When checking for degrees of freedom for metabolites, check if their time zero value is fixed instead of checking if the observed value is zero. This ensures correct calculation of degrees of freedom also in cases where the metabolite residue at time zero is greater zero.</p></li> -<li><p><code><a href="../reference/plot.mkinfit.html">plot.mkinfit()</a></code>: Avoid a warning message about only using the first component of ylim that occurred when ylim was specified explicitly</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-33">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-33"></a></h3> -<ul><li><p>The formatting of differential equations in the summary was improved by wrapping overly long lines</p></li> -<li><p>The FOCUS_Z vignette was rebuilt with the above improvement and using a width of 70 to avoid output outside of the grey area</p></li> -<li><p><code><a href="../reference/summary.mkinfit.html">print.summary.mkinfit()</a></code>: Avoid a warning that occurred when gmkin showed summaries of initial fits without iterations</p></li> -<li><p><code><a href="../reference/mkinfit.html">mkinfit()</a></code>: Avoid a warning that occurred when summarising a fit that was performed with maxitmodFit = 0 as done in gmkin for configuring new fits.</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-32" id="mkin-09-32-2014-07-24">mkin 0.9-32 (2014-07-24)<a class="anchor" aria-label="anchor" href="#mkin-09-32-2014-07-24"></a></h2> -<div class="section level3"> -<h3 id="new-features-0-9-32">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-32"></a></h3> -<ul><li><p>The number of degrees of freedom is difficult to define in the case of ilr transformation of formation fractions. Now for each source compartment the number of ilr parameters (=number of optimised parameters) is divided by the number of pathways to metabolites (=number of affected data series) which leads to fractional degrees of freedom in some cases.</p></li> -<li><p>The default for the initial value for the first state value is now taken from the mean of the observations at time zero, if available.</p></li> -<li><p>The kinetic model can alternatively be specified with a shorthand name for parent only degradation models, e.g. <code>SFO</code>, or <code>DFOP</code>.</p></li> -<li><p>Optimisation method, number of model evaluations and time elapsed during optimisation are given in the summary of mkinfit objects.</p></li> -<li><p>The maximum number of iterations in the optimisation algorithm can be specified using the argument <code>maxit.modFit</code> to the mkinfit function.</p></li> -<li><p>mkinfit gives a warning when the fit does not converge (does not apply to SANN method). This warning is included in the summary.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="bug-fixes-0-9-32">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-32"></a></h3> -<ul><li><p>Avoid plotting an artificial 0 residual at time zero in <code>mkinresplot</code></p></li> -<li><p>In the determination of the degrees of freedom in <code>mkinerrmin</code>, formation fractions were accounted for multiple times in the case of parallel formation of metabolites. See the new feature described above for the solution.</p></li> -<li><p><code>transform_rates=FALSE</code> in <code>mkinfit</code> now also works for FOMC and HS models.</p></li> -<li><p>Initial values for formation fractions were not set in all cases.</p></li> -<li><p>No warning was given when the fit did not converge when a method other than the default Levenberg-Marquardt method <code>Marq</code> was used.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-32">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-32"></a></h3> -<ul><li><p>Vignettes were rebuilt to reflect the changes in the summary method.</p></li> -<li><p>Algorithm <code>Pseudo</code> was excluded because it needs user-defined parameter limits which are not supported.</p></li> -<li><p>Algorithm <code>Newton</code> was excluded because of its different way to specify the maximum number of iterations and because it does not appear to provide additional benefits.</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-31" id="mkin-09-31-2014-07-14">mkin 0.9-31 (2014-07-14)<a class="anchor" aria-label="anchor" href="#mkin-09-31-2014-07-14"></a></h2> -<div class="section level3"> -<h3 id="bug-fixes-0-9-31">Bug fixes<a class="anchor" aria-label="anchor" href="#bug-fixes-0-9-31"></a></h3> -<ul><li>The internal renaming of optimised parameters in Version 0.9-30 led to errors in the determination of the degrees of freedom for the chi2 error level calulations in <code><a href="../reference/mkinerrmin.html">mkinerrmin()</a></code> used by the summary function.</li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-30" id="mkin-09-30-2014-07-11">mkin 0.9-30 (2014-07-11)<a class="anchor" aria-label="anchor" href="#mkin-09-30-2014-07-11"></a></h2> -<div class="section level3"> -<h3 id="new-features-0-9-30">New features<a class="anchor" aria-label="anchor" href="#new-features-0-9-30"></a></h3> -<ul><li>It is now possible to use formation fractions in combination with turning off the sink in <code><a href="../reference/mkinmod.html">mkinmod()</a></code>.</li> -</ul></div> -<div class="section level3"> -<h3 id="major-changes-0-9-30">Major changes<a class="anchor" aria-label="anchor" href="#major-changes-0-9-30"></a></h3> -<ul><li><p>The original and the transformed parameters now have different names (e.g. <code>k_parent</code> and <code>log_k_parent</code>. They also differ in how many they are when we have formation fractions but no pathway to sink.</p></li> -<li><p>The order of some of the information blocks in <code>print.summary.mkinfit.R()</code> has been ordered in a more logical way.</p></li> -</ul></div> -<div class="section level3"> -<h3 id="minor-changes-0-9-30">Minor changes<a class="anchor" aria-label="anchor" href="#minor-changes-0-9-30"></a></h3> -<ul><li><p>The vignette FOCUS_Z has been simplified to use formation fractions with turning off the sink, and slightly amended to use the new versions of DT50 values calculated since mkin 0.9-29.</p></li> -<li><p>All vignettes have been rebuilt so they reflect all changes.</p></li> -<li><p>The ChangeLog was renamed to NEWS.md and the entries were converted to markdown syntax compatible with the <code>tools::news()</code> function built into R.</p></li> -<li><p>The test suite was overhauled. Tests of the DFOP and SFORB models with dataset FOCUS_2006_A were removed, as they were too much dependent on the optimisation algorithm and/or starting parameters, because the dataset is SFO (compare kinfit vignette).</p></li> -<li><p>Also, the Schaefer complex case can now be fitted using formation fractions, and with the ‘Port’ optimisation method we also fit A2 in the same way as published in the Piacenza paper.</p></li> -<li><p>Some more checks were introduced to <code><a href="../reference/mkinfit.html">mkinfit()</a></code>, leading to warnings or stopping execution if unsupported combinations of methods and parameters are requested.</p></li> -</ul></div> -</div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-29" id="mkin-09-29-2014-06-27">mkin 0.9-29 (2014-06-27)<a class="anchor" aria-label="anchor" href="#mkin-09-29-2014-06-27"></a></h2> -<ul><li><p>R/mkinresplot.R: Make it possible to specify <code>xlim</code></p></li> -<li><p>R/geometric_mean.R, man/geometric_mean.Rd: Add geometric mean function</p></li> -<li><p>R/endpoints.R, man/endpoints.Rd: Calculate additional (pseudo)-DT50 values for FOMC, DFOP, HS and SFORB. Avoid calculation of formation fractions from rate constants when they are directly fitted</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-28" id="mkin-09-28-2014-05-20">mkin 0.9-28 (2014-05-20)<a class="anchor" aria-label="anchor" href="#mkin-09-28-2014-05-20"></a></h2> -<ul><li><p>Do not backtransform confidence intervals for formation fractions if more than one compound is formed, as such parameters only define the pathways as a set</p></li> -<li><p>Add historical remarks and some background to the main package vignette</p></li> -<li><p>Correct ‘isotropic’ into ‘isometric’ for the ilr transformation</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-27" id="mkin-09-27-2014-05-10">mkin 0.9-27 (2014-05-10)<a class="anchor" aria-label="anchor" href="#mkin-09-27-2014-05-10"></a></h2> -<ul><li><p>Fork the GUI into a separate package <a href="https://github.com/jranke/gmkin" class="external-link">gmkin</a></p></li> -<li><p>DESCRIPTION, NAMESPACE, TODO: Adapt and add copyright information</p></li> -<li><p>Remove files belonging to the GUI</p></li> -<li><p>Possibility to fit without parameter transformations, using bounds as implemented in FME</p></li> -<li><p>Add McCall 2,4,5-T dataset</p></li> -<li><p>Enable selection of observed variables in plotting</p></li> -<li><p>Add possibility to show residual plot in <code>plot.mkinfit</code></p></li> -<li><p>R/mkinparplot.R, man/mkinparplot.Rd: plot parameters with confidence intervals</p></li> -<li><p>Change vignette format from Sweave to knitr</p></li> -<li><p>Split examples vignette to FOCUS_L and FOCUS_Z</p></li> -<li><p>Remove warning about constant formation fractions in mkinmod as it was based on a misconception</p></li> -<li><p>Restrict the unit test with the Schaefer data to parent and primary metabolites as formation fraction and DT50 for A2 are highly correlated and passing the test is platform dependent. For example, the test fails in 1 out of 14 platforms on CRAN as of today.</p></li> -<li><p>Add Eurofins Regulatory AG copyright notices</p></li> -<li><p>Import FME and deSolve instead of depending on them to have clean startup</p></li> -<li><p>Add a starter function for the GUI: <code>gmkin()</code></p></li> -<li><p>Change the format of the workspace files of gmkin so they can be distributed and documented in the package</p></li> -<li><p>Add gmkin workspace datasets FOCUS_2006_gmkin and FOCUS_2006_Z_gmkin</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-24" id="mkin-09-24-2013-11-06">mkin 0.9-24 (2013-11-06)<a class="anchor" aria-label="anchor" href="#mkin-09-24-2013-11-06"></a></h2> -<ul><li><p>Bugfix re-enabling the fixing of any combination of initial values for state variables</p></li> -<li><p>Default values for kinetic rate constants are not all 0.1 any more but are “salted” with a small increment to avoid numeric artefacts with the eigenvalue based solutions</p></li> -<li><p>Backtransform fixed ODE parameters for the summary</p></li> -</ul></div> - <div class="section level2"> -<h2 class="page-header" data-toc-text="0.9-22" id="mkin-09-22-2013-10-26">mkin 0.9-22 (2013-10-26)<a class="anchor" aria-label="anchor" href="#mkin-09-22-2013-10-26"></a></h2> -<ul><li><p>Get rid of the optimisation step in <code>mkinerrmin</code> - this was unnecessary. Thanks to KinGUII for the inspiration - actually this is equation 6-2 in FOCUS kinetics p. 91 that I had overlooked originally</p></li> -<li><p>Fix <code>plot.mkinfit</code> as it passed graphical arguments like main to the solver</p></li> -<li><p>Do not use <code>plot=TRUE</code> in <code><a href="../reference/mkinfit.html">mkinfit()</a></code> example</p></li> -<li><p>The first successful fits in the not so simple GUI</p></li> -<li><p>Fix iteratively reweighted least squares for the case of many metabolites</p></li> -<li><p>Unify naming of initial values of state variables</p></li> -<li><p>Unify naming in dataframes of optimised and fixed parameters in the summary</p></li> -<li><p>Show the weighting method for residuals in the summary</p></li> -<li><p>Correct the output of the data in the case of manual weighting</p></li> -<li><p>Implement IRLS assuming different variances for observed variables</p></li> -<li><p>Do not use 0 values at time zero for chi2 error level calculations. This is the way it is done in KinGUII and it makes sense. It does impact the chi2 error levels in the output. Generally they seem to be lower for metabolites now, presumably because the mean of the observed values is higher</p></li> -</ul><p>For a detailed list of changes to the mkin source please consult the commit history on <a href="http://github.com/jranke/mkin" class="external-link uri">http://github.com/jranke/mkin</a></p> -</div> - </div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> - -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/pkgdown.css b/docs/dev/pkgdown.css deleted file mode 100644 index 80ea5b83..00000000 --- a/docs/dev/pkgdown.css +++ /dev/null @@ -1,384 +0,0 @@ -/* Sticky footer */ - -/** - * 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class="external-link"><code>R/AIC.mmkin.R</code></a></small> - <div class="hidden name"><code>AIC.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Provides a convenient way to compare different kinetic models fitted to the -same dataset.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span>, k <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An object of class <code><a href="mmkin.html">mmkin</a></code>, containing only one -column.</p></dd> - - -<dt>...</dt> -<dd><p>For compatibility with the generic method</p></dd> - - -<dt>k</dt> -<dd><p>As in the generic method</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>As in the generic method (a numeric value for single fits, or a -dataframe if there are several fits in the column).</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># skip, as it takes > 10 s on winbuilder</span></span></span> -<span class="r-in"><span> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span></span> -<span class="r-in"><span> <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="co"># We get a warning because the FOMC model does not converge for the</span></span></span> -<span class="r-in"><span> <span class="co"># FOCUS A dataset, as it is well described by SFO</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span> <span class="co"># We get a single number for a single fit</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 55.28197</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[[</span><span class="st">"SFO"</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span> <span class="co"># or when extracting an mkinfit object</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 55.28197</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># For FOCUS A, the models fit almost equally well, so the higher the number</span></span></span> -<span class="r-in"><span> <span class="co"># of parameters, the higher (worse) the AIC</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 3 55.28197</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC 4 57.28222</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 5 59.28197</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span>, k <span class="op">=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># If we do not penalize additional parameters, we get nearly the same</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 3 49.28197</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC 4 49.28222</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 5 49.28197</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS A"</span><span class="op">]</span><span class="op">)</span> <span class="co"># Comparing the BIC gives a very similar picture</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df BIC</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 3 55.52030</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC 4 57.59999</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 5 59.67918</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># For FOCUS C, the more complex models fit better</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 3 59.29336</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC 4 44.68652</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 5 29.02372</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">BIC</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df BIC</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 3 59.88504</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC 4 45.47542</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 5 30.00984</span> -<span class="r-in"><span> </span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav 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property="og:description" content="In addition to the datasets, the pathways in the degradation model can be -specified as well."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button 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class="fu">CAKE_export</span><span class="op">(</span></span> -<span> <span class="va">ds</span>,</span> -<span> map <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="st">"Parent"</span><span class="op">)</span>,</span> -<span> links <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> filename <span class="op">=</span> <span class="st">"CAKE_export.csf"</span>,</span> -<span> path <span class="op">=</span> <span class="st">"."</span>,</span> -<span> overwrite <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> study <span class="op">=</span> <span class="st">"Degradinol aerobic soil degradation"</span>,</span> -<span> description <span class="op">=</span> <span class="st">""</span>,</span> -<span> time_unit <span class="op">=</span> <span class="st">"days"</span>,</span> -<span> res_unit <span class="op">=</span> <span class="st">"% AR"</span>,</span> -<span> comment <span class="op">=</span> <span class="st">""</span>,</span> -<span> date <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Sys.time.html" class="external-link">Sys.Date</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> optimiser <span class="op">=</span> <span class="st">"IRLS"</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>ds</dt> -<dd><p>A named list of datasets in long format as compatible with -<code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>map</dt> -<dd><p>A character vector with CAKE compartment names (Parent, A1, ...), -named with the names used in the list of datasets.</p></dd> - - -<dt>links</dt> -<dd><p>An optional character vector of target compartments, named with -the names of the source compartments. In order to make this easier, the -names are used as in the datasets supplied.</p></dd> - - -<dt>filename</dt> -<dd><p>Where to write the result. Should end in .csf in order to be -compatible with CAKE.</p></dd> - - -<dt>path</dt> -<dd><p>An optional path to the output file.</p></dd> - - -<dt>overwrite</dt> -<dd><p>If TRUE, existing files are overwritten.</p></dd> - - -<dt>study</dt> -<dd><p>The name of the study.</p></dd> - - -<dt>description</dt> -<dd><p>An optional description.</p></dd> - - -<dt>time_unit</dt> -<dd><p>The time unit for the residue data.</p></dd> - - -<dt>res_unit</dt> -<dd><p>The unit used for the residues.</p></dd> - - -<dt>comment</dt> -<dd><p>An optional comment.</p></dd> - - -<dt>date</dt> -<dd><p>The date of file creation.</p></dd> - - -<dt>optimiser</dt> -<dd><p>Can be OLS or IRLS.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/D24_2014.html b/docs/dev/reference/D24_2014.html deleted file mode 100644 index 8af0a8e2..00000000 --- a/docs/dev/reference/D24_2014.html +++ /dev/null @@ -1,261 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 — D24_2014 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 — D24_2014"><meta property="og:description" content="The five datasets were extracted from the active substance evaluation dossier -published by EFSA. Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/D24_2014.R" class="external-link"><code>R/D24_2014.R</code></a></small> - <div class="hidden name"><code>D24_2014.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The five datasets were extracted from the active substance evaluation dossier -published by EFSA. Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">D24_2014</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>An <a href="mkindsg.html">mkindsg</a> object grouping five datasets</p> - </div> - <div id="source"> - <h2>Source</h2> - <p>Hellenic Ministry of Rural Development and Agriculture (2014) -Final addendum to the Renewal Assessment Report - public version - 2,4-D -Volume 3 Annex B.8 Fate and behaviour in the environment -<a href="https://open.efsa.europa.eu/study-inventory/EFSA-Q-2013-00811" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2013-00811</a></p> - </div> - <div id="details"> - <h2>Details</h2> - <p>Data for the first dataset are from p. 685. Data for the other four -datasets were used in the preprocessed versions given in the kinetics -section (p. 761ff.), with the exception of residues smaller than 1 for DCP -in the soil from Site I2, where the values given on p. 694 were used.</p> -<p>The R code used to create this data object is installed with this package -in the 'dataset_generation' directory. In the code, page numbers are given for -specific pieces of information in the comments.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">D24_2014</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> -<span class="r-out co"><span class="r-pr">#></span> Title $title: Aerobic soil degradation data on 2,4-D from the EU assessment in 2014 </span> -<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> -<span class="r-out co"><span class="r-pr">#></span> D24 DCP DCA </span> -<span class="r-out co"><span class="r-pr">#></span> 5 4 4 </span> -<span class="r-out co"><span class="r-pr">#></span> Time normalisation factors $f_time_norm:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1.6062378 0.7118732 0.7156063 0.7156063 0.8977124</span> -<span class="r-out co"><span class="r-pr">#></span> Meta information $meta:</span> -<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type</span> -<span class="r-out co"><span class="r-pr">#></span> Mississippi Cohen 1991 Silt loam <NA></span> -<span class="r-out co"><span class="r-pr">#></span> Fayette Liu and Adelfinskaya 2011 Silt loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> Site E1 Liu and Adelfinskaya 2011 Loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1</span> -<span class="r-out co"><span class="r-pr">#></span> rel_moisture temperature</span> -<span class="r-out co"><span class="r-pr">#></span> Mississippi NA 25</span> -<span class="r-out co"><span class="r-pr">#></span> Fayette 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> Site E1 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> Site I2 0.5 20</span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">D24_2014</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Mississippi </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: D24 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 2, 4, 7, 15, 24, 35, 56, 71, 114, 183, 273, 365 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 1 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> time D24</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 96.8</span> -<span class="r-out co"><span class="r-pr">#></span> 2 2 81.0</span> -<span class="r-out co"><span class="r-pr">#></span> 3 4 81.7</span> -<span class="r-out co"><span class="r-pr">#></span> 4 7 88.2</span> -<span class="r-out co"><span class="r-pr">#></span> 5 15 66.3</span> -<span class="r-out co"><span class="r-pr">#></span> 6 24 72.9</span> -<span class="r-out co"><span class="r-pr">#></span> 7 35 62.6</span> -<span class="r-out co"><span class="r-pr">#></span> 8 56 54.6</span> -<span class="r-out co"><span class="r-pr">#></span> 9 71 35.2</span> -<span class="r-out co"><span class="r-pr">#></span> 10 114 18.0</span> -<span class="r-out co"><span class="r-pr">#></span> 11 183 11.3</span> -<span class="r-out co"><span class="r-pr">#></span> 12 273 9.9</span> -<span class="r-out co"><span class="r-pr">#></span> 13 365 6.3</span> -<span class="r-in"><span><span class="va">m_D24</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>D24 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCP"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> DCP <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCA"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> DCA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">m_D24</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> -<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> -<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> -<span class="r-out co"><span class="r-pr">#></span> $D24</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCP; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> $DCP</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCA; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> $DCA</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> Coefficient matrix $coefmat available</span> -<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> -<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_D24/dt = - k_D24 * D24</span> -<span class="r-out co"><span class="r-pr">#></span> d_DCP/dt = + f_D24_to_DCP * k_D24 * D24 - k_DCP * DCP</span> -<span class="r-out co"><span class="r-pr">#></span> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</span> -<span class="r-in"><span><span class="va">m_D24_2</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>D24 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"DCP"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> DCP <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"DCA"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> DCA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">m_D24_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> -<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> -<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> -<span class="r-out co"><span class="r-pr">#></span> $D24</span> -<span class="r-out co"><span class="r-pr">#></span> $type: DFOP; $to: DCP; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> $DCP</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: DCA; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> $DCA</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> -<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_D24/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * D24</span> -<span class="r-out co"><span class="r-pr">#></span> d_DCP/dt = + f_D24_to_DCP * ((k1 * g * exp(-k1 * time) + k2 * (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2</span> -<span class="r-out co"><span class="r-pr">#></span> * time))) * D24 - k_DCP * DCP</span> -<span class="r-out co"><span class="r-pr">#></span> d_DCA/dt = + f_DCP_to_DCA * k_DCP * DCP - k_DCA * DCA</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 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name"><code>DFOP.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing decline from a defined starting value using the sum of -two exponential decline functions.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>k1</dt> -<dd><p>First kinetic constant.</p></dd> - - -<dt>k2</dt> -<dd><p>Second kinetic constant.</p></dd> - - -<dt>g</dt> -<dd><p>Fraction of the starting value declining according to the first -kinetic constant.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">DFOP.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">5</span>, <span class="fl">0.5</span>, <span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">4</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="DFOP.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a 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</ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Subsetting method for mmkin objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mmkin.R" class="external-link"><code>R/mmkin.R</code></a></small> - <div class="hidden name"><code>Extract.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Subsetting method for mmkin objects</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre><code># S3 method for mmkin -[(x, i, j, ..., drop = FALSE)</code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An <code><a href="mmkin.html">mmkin</a> object</code></p></dd> - - -<dt>i</dt> -<dd><p>Row index selecting the fits for specific models</p></dd> - - -<dt>j</dt> -<dd><p>Column index selecting the fits to specific datasets</p></dd> - - -<dt>...</dt> -<dd><p>Not used, only there to satisfy the generic method definition</p></dd> - - -<dt>drop</dt> -<dd><p>If FALSE, the method always returns an mmkin object, otherwise -either a list of mkinfit objects or a single mkinfit object.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An object of class <code><a href="mmkin.html">mmkin</a></code>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># Only use one core, to pass R CMD check --as-cran</span></span></span> -<span class="r-in"><span> <span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>B <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, C <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model B C </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span> <span class="va">fits</span><span class="op">[</span>, <span class="st">"B"</span><span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model B </span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span> <span class="va">fits</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="st">"B"</span><span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model B </span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="co"># This extracts an mkinfit object with lots of components</span></span></span> -<span class="r-in"><span> <span class="va">fits</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="st">"B"</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span> <span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $par</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_alpha log_beta sigma </span> -<span class="r-out co"><span class="r-pr">#></span> 99.666192 2.549850 5.050586 1.890202 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $objective</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 28.58291</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $convergence</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $iterations</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 21</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $evaluations</span> -<span class="r-out co"><span class="r-pr">#></span> function gradient </span> -<span class="r-out co"><span class="r-pr">#></span> 25 78 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $message</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "both X-convergence and relative convergence (5)"</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html b/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html deleted file mode 100644 index a8eb25cf..00000000 --- a/docs/dev/reference/FOCUS_2006_DFOP_ref_A_to_B.html +++ /dev/null @@ -1,189 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Results of fitting the DFOP model to Datasets A to B of FOCUS (2006) — FOCUS_2006_DFOP_ref_A_to_B • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" 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property="og:title" content="Results of fitting the DFOP model to Datasets A to B of FOCUS (2006) — FOCUS_2006_DFOP_ref_A_to_B"><meta property="og:description" content="A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)</h1> - - <div class="hidden name"><code>FOCUS_2006_DFOP_ref_A_to_B.Rd</code></div> - </div> - - <div class="ref-description"> - <p>A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">FOCUS_2006_DFOP_ref_A_to_B</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> -<dd><p>a factor giving the name of the software package</p></dd> - - <dt><code>M0</code></dt> -<dd><p>The fitted initial concentration of the parent compound</p></dd> - - <dt><code>f</code></dt> -<dd><p>The fitted f parameter</p></dd> - - <dt><code>k1</code></dt> -<dd><p>The fitted k1 parameter</p></dd> - - <dt><code>k2</code></dt> -<dd><p>The fitted k2 parameter</p></dd> - - <dt><code>DT50</code></dt> -<dd><p>The resulting half-life of the parent compound</p></dd> - - <dt><code>DT90</code></dt> -<dd><p>The resulting DT90 of the parent compound</p></dd> - - <dt><code>dataset</code></dt> -<dd><p>The FOCUS dataset that was used</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_DFOP_ref_A_to_B</span><span class="op">)</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html deleted file mode 100644 index 24297c78..00000000 --- a/docs/dev/reference/FOCUS_2006_FOMC_ref_A_to_F.html +++ /dev/null @@ -1,186 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006) — FOCUS_2006_FOMC_ref_A_to_F • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Results of fitting the FOMC model to Datasets A to F of FOCUS (2006) — FOCUS_2006_FOMC_ref_A_to_F"><meta property="og:description" content="A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)</h1> - - <div class="hidden name"><code>FOCUS_2006_FOMC_ref_A_to_F.Rd</code></div> - </div> - - <div class="ref-description"> - <p>A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">FOCUS_2006_FOMC_ref_A_to_F</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> -<dd><p>a factor giving the name of the software package</p></dd> - - <dt><code>M0</code></dt> -<dd><p>The fitted initial concentration of the parent compound</p></dd> - - <dt><code>alpha</code></dt> -<dd><p>The fitted alpha parameter</p></dd> - - <dt><code>beta</code></dt> -<dd><p>The fitted beta parameter</p></dd> - - <dt><code>DT50</code></dt> -<dd><p>The resulting half-life of the parent compound</p></dd> - - <dt><code>DT90</code></dt> -<dd><p>The resulting DT90 of the parent compound</p></dd> - - <dt><code>dataset</code></dt> -<dd><p>The FOCUS dataset that was used</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_FOMC_ref_A_to_F</span><span class="op">)</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html deleted file mode 100644 index caf258ba..00000000 --- a/docs/dev/reference/FOCUS_2006_HS_ref_A_to_F.html +++ /dev/null @@ -1,189 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Results of fitting the HS model to Datasets A to F of FOCUS (2006)</h1> - - <div class="hidden name"><code>FOCUS_2006_HS_ref_A_to_F.Rd</code></div> - </div> - - <div class="ref-description"> - <p>A table with the fitted parameters and the resulting DT50 and DT90 values -generated with different software packages. Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">FOCUS_2006_HS_ref_A_to_F</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> -<dd><p>a factor giving the name of the software package</p></dd> - - <dt><code>M0</code></dt> -<dd><p>The fitted initial concentration of the parent compound</p></dd> - - <dt><code>tb</code></dt> -<dd><p>The fitted tb parameter</p></dd> - - <dt><code>k1</code></dt> -<dd><p>The fitted k1 parameter</p></dd> - - <dt><code>k2</code></dt> -<dd><p>The fitted k2 parameter</p></dd> - - <dt><code>DT50</code></dt> -<dd><p>The resulting half-life of the parent compound</p></dd> - - <dt><code>DT90</code></dt> -<dd><p>The resulting DT90 of the parent compound</p></dd> - - <dt><code>dataset</code></dt> -<dd><p>The FOCUS dataset that was used</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_HS_ref_A_to_F</span><span class="op">)</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html b/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html deleted file mode 100644 index bc3d1c08..00000000 --- a/docs/dev/reference/FOCUS_2006_SFO_ref_A_to_F.html +++ /dev/null @@ -1,183 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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Taken directly from FOCUS (2006). -The results from fitting the data with the Topfit software was removed, as -the initial concentration of the parent compound was fixed to a value of 100 -in this fit.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">FOCUS_2006_SFO_ref_A_to_F</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A data frame containing the following variables.</p><dl><dt><code>package</code></dt> -<dd><p>a factor giving the name of the software package</p></dd> - - <dt><code>M0</code></dt> -<dd><p>The fitted initial concentration of the parent compound</p></dd> - - <dt><code>k</code></dt> -<dd><p>The fitted first-order degradation rate constant</p></dd> - - <dt><code>DT50</code></dt> -<dd><p>The resulting half-life of the parent compound</p></dd> - - <dt><code>DT90</code></dt> -<dd><p>The resulting DT90 of the parent compound</p></dd> - - <dt><code>dataset</code></dt> -<dd><p>The FOCUS dataset that was used</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">FOCUS_2006_SFO_ref_A_to_F</span><span class="op">)</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOCUS_2006_datasets.html b/docs/dev/reference/FOCUS_2006_datasets.html deleted file mode 100644 index 78f8e81b..00000000 --- a/docs/dev/reference/FOCUS_2006_datasets.html +++ /dev/null @@ -1,181 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Datasets A to F from the FOCUS Kinetics report from 2006 — FOCUS_2006_datasets • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Datasets A to F from the FOCUS Kinetics report from 2006 — FOCUS_2006_datasets"><meta property="og:description" content="Data taken from FOCUS (2006), p. 258."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - 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<li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Datasets A to F from the FOCUS Kinetics report from 2006</h1> - - <div class="hidden name"><code>FOCUS_2006_datasets.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Data taken from FOCUS (2006), p. 258.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">FOCUS_2006_A</span></span> -<span> <span class="va">FOCUS_2006_B</span></span> -<span> <span class="va">FOCUS_2006_C</span></span> -<span> <span class="va">FOCUS_2006_D</span></span> -<span> <span class="va">FOCUS_2006_E</span></span> -<span> <span class="va">FOCUS_2006_F</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>6 datasets with observations on the following variables.</p><dl><dt><code>name</code></dt> -<dd><p>a factor containing the name of the observed variable</p></dd> - - <dt><code>time</code></dt> -<dd><p>a numeric vector containing time points</p></dd> - - <dt><code>value</code></dt> -<dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">FOCUS_2006_C</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> name time value</span> -<span class="r-out co"><span class="r-pr">#></span> 1 parent 0 85.1</span> -<span class="r-out co"><span class="r-pr">#></span> 2 parent 1 57.9</span> -<span class="r-out co"><span class="r-pr">#></span> 3 parent 3 29.9</span> -<span class="r-out co"><span class="r-pr">#></span> 4 parent 7 14.6</span> -<span class="r-out co"><span class="r-pr">#></span> 5 parent 14 9.7</span> -<span class="r-out co"><span class="r-pr">#></span> 6 parent 28 6.6</span> -<span class="r-out co"><span class="r-pr">#></span> 7 parent 63 4.0</span> -<span class="r-out co"><span class="r-pr">#></span> 8 parent 91 3.9</span> -<span class="r-out co"><span class="r-pr">#></span> 9 parent 119 0.6</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/FOMC.solution-1.png b/docs/dev/reference/FOMC.solution-1.png Binary files differdeleted file mode 100644 index 18a4b586..00000000 --- a/docs/dev/reference/FOMC.solution-1.png +++ /dev/null diff --git a/docs/dev/reference/FOMC.solution.html b/docs/dev/reference/FOMC.solution.html deleted file mode 100644 index e1813261..00000000 --- a/docs/dev/reference/FOMC.solution.html +++ /dev/null @@ -1,213 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>First-Order Multi-Compartment kinetics — FOMC.solution • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="First-Order Multi-Compartment kinetics — FOMC.solution"><meta property="og:description" content="Function describing exponential decline from a defined starting value, with -a decreasing rate constant."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - 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<li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>First-Order Multi-Compartment kinetics</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> - <div class="hidden name"><code>FOMC.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing exponential decline from a defined starting value, with -a decreasing rate constant.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">alpha</span>, <span class="va">beta</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>alpha</dt> -<dd><p>Shape parameter determined by coefficient of variation of rate -constant values.</p></dd> - - -<dt>beta</dt> -<dd><p>Location parameter.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>The form given here differs slightly from the original reference by -Gustafson and Holden (1990). The parameter <code>beta</code> corresponds to 1/beta -in the original equation.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>The solution of the FOMC kinetic model reduces to the -<code><a href="SFO.solution.html">SFO.solution</a></code> for large values of <code>alpha</code> and <code>beta</code> -with \(k = \frac{\beta}{\alpha}\).</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> -<p>FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> -<p>Gustafson DI and Holden LR (1990) Nonlinear pesticide dissipation in soil: -A new model based on spatial variability. <em>Environmental Science and -Technology</em> <b>24</b>, 1032-1038</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">FOMC.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">10</span>, <span class="fl">2</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="FOMC.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/HS.solution-1.png b/docs/dev/reference/HS.solution-1.png Binary files differdeleted file mode 100644 index 61d89dbc..00000000 --- a/docs/dev/reference/HS.solution-1.png +++ /dev/null diff --git a/docs/dev/reference/HS.solution.html b/docs/dev/reference/HS.solution.html deleted file mode 100644 index d42eaef6..00000000 --- a/docs/dev/reference/HS.solution.html +++ /dev/null @@ -1,203 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Hockey-Stick kinetics — HS.solution • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Hockey-Stick kinetics — HS.solution"><meta property="og:description" content="Function describing two exponential decline functions with a break point -between them."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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<li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Hockey-Stick kinetics</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> - <div class="hidden name"><code>HS.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing two exponential decline functions with a break point -between them.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">HS.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">tb</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>k1</dt> -<dd><p>First kinetic constant.</p></dd> - - -<dt>k2</dt> -<dd><p>Second kinetic constant.</p></dd> - - -<dt>tb</dt> -<dd><p>Break point. Before this time, exponential decline according to -<code>k1</code> is calculated, after this time, exponential decline proceeds -according to <code>k2</code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">HS.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">2</span>, <span class="fl">0.3</span>, <span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim<span class="op">=</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>,<span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="HS.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/IORE.solution-1.png b/docs/dev/reference/IORE.solution-1.png Binary files differdeleted file mode 100644 index 54c9dcae..00000000 --- a/docs/dev/reference/IORE.solution-1.png +++ /dev/null diff --git a/docs/dev/reference/IORE.solution.html b/docs/dev/reference/IORE.solution.html deleted file mode 100644 index b9d4734f..00000000 --- a/docs/dev/reference/IORE.solution.html +++ /dev/null @@ -1,218 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Indeterminate order rate equation kinetics — IORE.solution • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Indeterminate order rate equation kinetics — IORE.solution"><meta property="og:description" content="Function describing exponential decline from a defined starting value, with -a concentration dependent rate constant."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Indeterminate order rate equation kinetics</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> - <div class="hidden name"><code>IORE.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing exponential decline from a defined starting value, with -a concentration dependent rate constant.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">IORE.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k__iore</span>, <span class="va">N</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>k__iore</dt> -<dd><p>Rate constant. Note that this depends on the concentration -units used.</p></dd> - - -<dt>N</dt> -<dd><p>Exponent describing the nonlinearity of the rate equation</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>The solution of the IORE kinetic model reduces to the -<code><a href="SFO.solution.html">SFO.solution</a></code> if N = 1. The parameters of the IORE model can -be transformed to equivalent parameters of the FOMC mode - see the NAFTA -guidance for details.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>NAFTA Technical Working Group on Pesticides (not dated) Guidance -for Evaluating and Calculating Degradation Kinetics in Environmental Media</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">IORE.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.2</span>, <span class="fl">1.3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="IORE.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit.fomc</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">fit.iore</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">fit.iore.deS</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"IORE"</span>, <span class="va">FOCUS_2006_C</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Error in is.loaded(initfunc, PACKAGE = dllname, type = "") : </span> -<span class="r-out co"><span class="r-pr">#></span> invalid 'PACKAGE' argument</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore</span><span class="op">$</span><span class="va">par</span>, <span class="va">fit.iore.deS</span><span class="op">$</span><span class="va">par</span>,</span></span> -<span class="r-in"><span> row.names <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"model par"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> fit.fomc.par fit.iore.par fit.iore.deS.par</span> -<span class="r-out co"><span class="r-pr">#></span> model par 1 85.87489063 85.874890 85.874890</span> -<span class="r-out co"><span class="r-pr">#></span> model par 2 0.05192238 -4.826631 -4.826631</span> -<span class="r-out co"><span class="r-pr">#></span> model par 3 0.65096665 1.949403 1.949403</span> -<span class="r-out co"><span class="r-pr">#></span> model par 4 1.85744396 1.857444 1.857444</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span>fomc <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.fomc</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>, iore <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span>,</span></span> -<span class="r-in"><span> iore.deS <span class="op">=</span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.iore</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> -<span class="r-out co"><span class="r-pr">#></span> fomc 1.785233 15.1479 4.559973</span> -<span class="r-out co"><span class="r-pr">#></span> iore 1.785233 15.1479 4.559973</span> -<span class="r-out co"><span class="r-pr">#></span> iore.deS 1.785233 15.1479 4.559973</span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/NAFTA_SOP_2015-1.png b/docs/dev/reference/NAFTA_SOP_2015-1.png Binary files differdeleted 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</button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Example datasets from the NAFTA SOP published 2015</h1> - - <div class="hidden name"><code>NAFTA_SOP_2015.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Data taken from US EPA (2015), p. 19 and 23.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">NAFTA_SOP_Appendix_B</span></span> -<span> <span class="va">NAFTA_SOP_Appendix_D</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>2 datasets with observations on the following variables.</p><dl><dt><code>name</code></dt> -<dd><p>a factor containing the name of the observed variable</p></dd> - - <dt><code>time</code></dt> -<dd><p>a numeric vector containing time points</p></dd> - - <dt><code>value</code></dt> -<dd><p>a numeric vector containing concentrations</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>NAFTA (2011) Guidance for evaluating and calculating degradation kinetics - in environmental media. NAFTA Technical Working Group on Pesticides - <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> - accessed 2019-02-22</p> -<p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to - Calculate Representative Half-life Values and Characterizing Pesticide - Degradation - <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span> <span class="va">nafta_evaluation</span> <span class="op"><-</span> <span class="fu"><a href="nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Appendix_D</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> -<span class="r-msg co"><span class="r-pr">#></span> The representative half-life of the IORE model is longer than the one corresponding</span> -<span class="r-msg co"><span class="r-pr">#></span> to the terminal degradation rate found with the DFOP model.</span> -<span class="r-msg co"><span class="r-pr">#></span> The representative half-life obtained from the DFOP model may be used</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> -<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> -<span class="r-out co"><span class="r-pr">#></span> 1378.6832 615.7730 517.8836 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 717.4598</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 83.7558 1.80e-14 77.18268 90.3288</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0017 7.43e-05 0.00112 0.0026</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 8.7518 1.22e-05 5.64278 11.8608</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $IORE</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 9.69e+01 NA 8.88e+01 1.05e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09</span> -<span class="r-out co"><span class="r-pr">#></span> N_parent 6.68e+00 NA 4.19e+00 9.17e+00</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.85e+00 NA 3.76e+00 7.94e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03</span> -<span class="r-out co"><span class="r-pr">#></span> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 407 1350 407</span> -<span class="r-out co"><span class="r-pr">#></span> IORE 541 5190000 1560000</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 429 2380 841</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 841.41</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="NAFTA_SOP_2015-1.png" alt="" width="700" height="433"></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git 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href="nafta.html">nafta</a></code></p> - </div> - <div id="source"> - <h2>Source</h2> - <p>NAFTA (2011) Guidance for evaluating and calculating degradation kinetics - in environmental media. NAFTA Technical Working Group on Pesticides - <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> - accessed 2019-02-22</p> -<p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to - Calculate Representative Half-life Values and Characterizing Pesticide - Degradation - <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span> <span class="va">nafta_att_p5a</span> <span class="op"><-</span> <span class="fu"><a href="nafta.html">nafta</a></span><span class="op">(</span><span class="va">NAFTA_SOP_Attachment</span><span class="op">[[</span><span class="st">"p5a"</span><span class="op">]</span><span class="op">]</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> -<span class="r-msg co"><span class="r-pr">#></span> The half-life obtained from the IORE model may be used</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_att_p5a</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> -<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> -<span class="r-out co"><span class="r-pr">#></span> 465.21753 56.27506 32.06401 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 64.4304</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 95.8401 4.67e-21 92.245 99.4357</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0102 3.92e-12 0.009 0.0117</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 4.8230 3.81e-06 3.214 6.4318</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $IORE</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.01e+02 NA 9.91e+01 1.02e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 1.54e-05 NA 4.08e-06 5.84e-05</span> -<span class="r-out co"><span class="r-pr">#></span> N_parent 2.57e+00 NA 2.25e+00 2.89e+00</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.68e+00 NA 1.12e+00 2.24e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 9.99e+01 1.41e-26 98.8116 101.0810</span> -<span class="r-out co"><span class="r-pr">#></span> k1 2.67e-02 5.05e-06 0.0243 0.0295</span> -<span class="r-out co"><span class="r-pr">#></span> k2 2.26e-12 5.00e-01 0.0000 Inf</span> -<span class="r-out co"><span class="r-pr">#></span> g 6.47e-01 3.67e-06 0.6248 0.6677</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.27e+00 8.91e-06 0.8395 1.6929</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 67.7 2.25e+02 6.77e+01</span> -<span class="r-out co"><span class="r-pr">#></span> IORE 58.2 1.07e+03 3.22e+02</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 55.5 5.59e+11 3.07e+11</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 321.51</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_att_p5a</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="NAFTA_SOP_Attachment-1.png" alt="" width="700" height="433"></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/Rplot001.png b/docs/dev/reference/Rplot001.png Binary files differdeleted file mode 100644 index 70d084a3..00000000 --- a/docs/dev/reference/Rplot001.png +++ 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class="va">parent_0</span>, <span class="va">k</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>k</dt> -<dd><p>Kinetic rate constant.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFO.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="SFO.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> 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property="og:description" content="Function describing the solution of the differential equations describing -the kinetic model with first-order terms for a two-way transfer from a free -to a bound fraction, and a first-order degradation term for the free -fraction. The initial condition is a defined amount in the free fraction -and no substance in the bound fraction."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Single First-Order Reversible Binding kinetics</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> - <div class="hidden name"><code>SFORB.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing the solution of the differential equations describing -the kinetic model with first-order terms for a two-way transfer from a free -to a bound fraction, and a first-order degradation term for the free -fraction. The initial condition is a defined amount in the free fraction -and no substance in the bound fraction.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">k_12</span>, <span class="va">k_21</span>, <span class="va">k_1output</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>k_12</dt> -<dd><p>Kinetic constant describing transfer from free to bound.</p></dd> - - -<dt>k_21</dt> -<dd><p>Kinetic constant describing transfer from bound to free.</p></dd> - - -<dt>k_1output</dt> -<dd><p>Kinetic constant describing degradation of the free -fraction.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable, which is the sum of free and -bound fractions at time <code>t</code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="logistic.solution.html">logistic.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">SFORB.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.5</span>, <span class="fl">2</span>, <span class="fl">3</span><span class="op">)</span>, <span class="fl">0</span>, <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="SFORB.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/add_err-1.png b/docs/dev/reference/add_err-1.png Binary files differdeleted file mode 100644 index 68cfb344..00000000 --- a/docs/dev/reference/add_err-1.png +++ /dev/null diff --git a/docs/dev/reference/add_err-2.png b/docs/dev/reference/add_err-2.png Binary files differdeleted file mode 100644 index d2f0cf08..00000000 --- a/docs/dev/reference/add_err-2.png +++ /dev/null diff --git a/docs/dev/reference/add_err-3.png b/docs/dev/reference/add_err-3.png Binary files differdeleted file mode 100644 index 17b5416a..00000000 --- a/docs/dev/reference/add_err-3.png +++ /dev/null diff --git a/docs/dev/reference/add_err.html b/docs/dev/reference/add_err.html deleted file mode 100644 index 57db40d1..00000000 --- a/docs/dev/reference/add_err.html +++ /dev/null @@ -1,262 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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The variance of the error -may depend on the predicted value and is specified as a standard deviation."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Add normally distributed errors to simulated kinetic degradation data</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/add_err.R" class="external-link"><code>R/add_err.R</code></a></small> - <div class="hidden name"><code>add_err.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Normally distributed errors are added to data predicted for a specific -degradation model using <code><a href="mkinpredict.html">mkinpredict</a></code>. The variance of the error -may depend on the predicted value and is specified as a standard deviation.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">add_err</span><span class="op">(</span></span> -<span> <span class="va">prediction</span>,</span> -<span> <span class="va">sdfunc</span>,</span> -<span> secondary <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span> -<span> n <span class="op">=</span> <span class="fl">10</span>,</span> -<span> LOD <span class="op">=</span> <span class="fl">0.1</span>,</span> -<span> reps <span class="op">=</span> <span class="fl">2</span>,</span> -<span> digits <span class="op">=</span> <span class="fl">1</span>,</span> -<span> seed <span class="op">=</span> <span class="cn">NA</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>prediction</dt> -<dd><p>A prediction from a kinetic model as produced by -<code><a href="mkinpredict.html">mkinpredict</a></code>.</p></dd> - - -<dt>sdfunc</dt> -<dd><p>A function taking the predicted value as its only argument and -returning a standard deviation that should be used for generating the -random error terms for this value.</p></dd> - - -<dt>secondary</dt> -<dd><p>The names of state variables that should have an initial -value of zero</p></dd> - - -<dt>n</dt> -<dd><p>The number of datasets to be generated.</p></dd> - - -<dt>LOD</dt> -<dd><p>The limit of detection (LOD). Values that are below the LOD after -adding the random error will be set to NA.</p></dd> - - -<dt>reps</dt> -<dd><p>The number of replicates to be generated within the datasets.</p></dd> - - -<dt>digits</dt> -<dd><p>The number of digits to which the values will be rounded.</p></dd> - - -<dt>seed</dt> -<dd><p>The seed used for the generation of random numbers. If NA, the -seed is not set.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A list of datasets compatible with <code><a href="mmkin.html">mmkin</a></code>, i.e. the -components of the list are datasets compatible with <code><a href="mkinfit.html">mkinfit</a></code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Ranke J and Lehmann R (2015) To t-test or not to t-test, that is -the question. XV Symposium on Pesticide Chemistry 2-4 September 2015, -Piacenza, Italy -https://jrwb.de/posters/piacenza_2015.pdf</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The kinetic model</span></span></span> -<span class="r-in"><span><span class="va">m_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Generate a prediction for a specific set of parameters</span></span></span> -<span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># This is the prediction used for the "Type 2 datasets" on the Piacenza poster</span></span></span> -<span class="r-in"><span><span class="co"># from 2015</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.1</span>, f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>,</span></span> -<span class="r-in"><span> k_M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">1000</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Add an error term with a constant (independent of the value) standard deviation</span></span></span> -<span class="r-in"><span><span class="co"># of 10, and generate three datasets</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_SFO_err</span> <span class="op"><-</span> <span class="fu">add_err</span><span class="op">(</span><span class="va">d_SFO_SFO</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fl">10</span>, n <span class="op">=</span> <span class="fl">3</span>, seed <span class="op">=</span> <span class="fl">123456789</span> <span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Name the datasets for nicer plotting</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">d_SFO_SFO_err</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Name the model in the list of models (with only one member in this case) for</span></span></span> -<span class="r-in"><span><span class="co"># nicer plotting later on. Be quiet and use only one core not to offend CRAN</span></span></span> -<span class="r-in"><span><span class="co"># checks</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">f_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">m_SFO_SFO</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">d_SFO_SFO_err</span>, cores <span class="op">=</span> <span class="fl">1</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="add_err-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># We would like to inspect the fit for dataset 3 more closely</span></span></span> -<span class="r-in"><span><span class="co"># Using double brackets makes the returned object an mkinfit object</span></span></span> -<span class="r-in"><span><span class="co"># instead of a list of mkinfit objects, so plot.mkinfit is used</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">[[</span><span class="fl">3</span><span class="op">]</span><span class="op">]</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="add_err-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># If we use single brackets, we should give two indices (model and dataset),</span></span></span> -<span class="r-in"><span><span class="co"># and plot.mmkin is used</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_SFO_SFO</span><span class="op">[</span><span class="fl">1</span>, <span class="fl">3</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="add_err-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/anova.saem.mmkin.html b/docs/dev/reference/anova.saem.mmkin.html deleted file mode 100644 index 39a30dff..00000000 --- a/docs/dev/reference/anova.saem.mmkin.html +++ /dev/null @@ -1,185 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Anova method for saem.mmkin objects — anova.saem.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Anova method for saem.mmkin objects — anova.saem.mmkin"><meta property="og:description" content="Generate an anova object. The method to calculate the BIC is that from the -saemix package. As in other prominent anova methods, models are sorted by -number of parameters, and the tests (if requested) are always relative to -the model on the previous line."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Anova method for saem.mmkin objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/anova.saem.mmkin.R" class="external-link"><code>R/anova.saem.mmkin.R</code></a></small> - <div class="hidden name"><code>anova.saem.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Generate an anova object. The method to calculate the BIC is that from the -saemix package. As in other prominent anova methods, models are sorted by -number of parameters, and the tests (if requested) are always relative to -the model on the previous line.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> <span class="va">...</span>,</span> -<span> method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"is"</span>, <span class="st">"lin"</span>, <span class="st">"gq"</span><span class="op">)</span>,</span> -<span> test <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> model.names <span class="op">=</span> <span class="cn">NULL</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <a href="saem.html">saem.mmkin</a> object</p></dd> - - -<dt>...</dt> -<dd><p>further such objects</p></dd> - - -<dt>method</dt> -<dd><p>Method for likelihood calculation: "is" (importance sampling), -"lin" (linear approximation), or "gq" (Gaussian quadrature). Passed -to <a href="https://rdrr.io/pkg/saemix/man/logLik.html" class="external-link">saemix::logLik.SaemixObject</a></p></dd> - - -<dt>test</dt> -<dd><p>Should a likelihood ratio test be performed? If TRUE, -the alternative models are tested against the first model. Should -only be done for nested models.</p></dd> - - -<dt>model.names</dt> -<dd><p>Optional character vector of model names</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>an "anova" data frame; the traditional (S3) result of anova()</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/aw.html b/docs/dev/reference/aw.html deleted file mode 100644 index fc5ff777..00000000 --- a/docs/dev/reference/aw.html +++ /dev/null @@ -1,197 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Calculate Akaike weights for model averaging — aw • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Calculate Akaike weights for model averaging — aw"><meta property="og:description" content="Akaike weights are calculated based on the relative -expected Kullback-Leibler information as specified -by Burnham and Anderson (2004)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Calculate Akaike weights for model averaging</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/aw.R" class="external-link"><code>R/aw.R</code></a></small> - <div class="hidden name"><code>aw.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Akaike weights are calculated based on the relative -expected Kullback-Leibler information as specified -by Burnham and Anderson (2004).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mixed.mmkin</span></span> -<span><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for multistart</span></span> -<span><span class="fu">aw</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <a href="mmkin.html">mmkin</a> column object, containing two or more -<a href="mkinfit.html">mkinfit</a> models that have been fitted to the same data, -or an mkinfit object. In the latter case, further mkinfit -objects fitted to the same data should be specified -as dots arguments.</p></dd> - - -<dt>...</dt> -<dd><p>Not used in the method for <a href="mmkin.html">mmkin</a> column objects, -further <a href="mkinfit.html">mkinfit</a> objects in the method for mkinfit objects.</p></dd> - -</dl></div> - <div id="references"> - <h2>References</h2> - <p>Burnham KP and Anderson DR (2004) Multimodel -Inference: Understanding AIC and BIC in Model Selection. -<em>Sociological Methods & Research</em> <strong>33</strong>(2) 261-304</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">f_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_dfop</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">aw_sfo_dfop</span> <span class="op"><-</span> <span class="fu">aw</span><span class="op">(</span><span class="va">f_sfo</span>, <span class="va">f_dfop</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="va">aw_sfo_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> -<span class="r-in"><span><span class="va">aw_sfo_dfop</span> <span class="co"># SFO gets more weight as it has less parameters and a similar fit</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.5970258 0.4029742</span> -<span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS D"</span> <span class="op">=</span> <span class="va">FOCUS_2006_D</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.4808722 0.1945539 0.3245740</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> -<span class="r-in"><span><span class="fu">aw</span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.5970258 0.4029742</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/confint.mkinfit.html b/docs/dev/reference/confint.mkinfit.html deleted file mode 100644 index a3571fa5..00000000 --- a/docs/dev/reference/confint.mkinfit.html +++ /dev/null @@ -1,423 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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The 'profile' method uses two nested optimisations and can take a -very long time, even if parallelized by specifying 'cores' on unixoid -platforms. The speed of the method could likely be improved by using the -method of Venzon and Moolgavkar (1988)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - 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<span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Confidence intervals for parameters of mkinfit objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/confint.mkinfit.R" class="external-link"><code>R/confint.mkinfit.R</code></a></small> - <div class="hidden name"><code>confint.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The default method 'quadratic' is based on the quadratic approximation of -the curvature of the likelihood function at the maximum likelihood parameter -estimates. -The alternative method 'profile' is based on the profile likelihood for each -parameter. The 'profile' method uses two nested optimisations and can take a -very long time, even if parallelized by specifying 'cores' on unixoid -platforms. The speed of the method could likely be improved by using the -method of Venzon and Moolgavkar (1988).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> <span class="va">parm</span>,</span> -<span> level <span class="op">=</span> <span class="fl">0.95</span>,</span> -<span> alpha <span class="op">=</span> <span class="fl">1</span> <span class="op">-</span> <span class="va">level</span>,</span> -<span> <span class="va">cutoff</span>,</span> -<span> method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"quadratic"</span>, <span class="st">"profile"</span><span class="op">)</span>,</span> -<span> transformed <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> backtransform <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> cores <span class="op">=</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> rel_tol <span class="op">=</span> <span class="fl">0.01</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <code><a href="mkinfit.html">mkinfit</a></code> object</p></dd> - - -<dt>parm</dt> -<dd><p>A vector of names of the parameters which are to be given -confidence intervals. If missing, all parameters are considered.</p></dd> - - -<dt>level</dt> -<dd><p>The confidence level required</p></dd> - - -<dt>alpha</dt> -<dd><p>The allowed error probability, overrides 'level' if specified.</p></dd> - - -<dt>cutoff</dt> -<dd><p>Possibility to specify an alternative cutoff for the difference -in the log-likelihoods at the confidence boundary. Specifying an explicit -cutoff value overrides arguments 'level' and 'alpha'</p></dd> - - -<dt>method</dt> -<dd><p>The 'quadratic' method approximates the likelihood function at -the optimised parameters using the second term of the Taylor expansion, -using a second derivative (hessian) contained in the object. -The 'profile' method searches the parameter space for the -cutoff of the confidence intervals by means of a likelihood ratio test.</p></dd> - - -<dt>transformed</dt> -<dd><p>If the quadratic approximation is used, should it be -applied to the likelihood based on the transformed parameters?</p></dd> - - -<dt>backtransform</dt> -<dd><p>If we approximate the likelihood in terms of the -transformed parameters, should we backtransform the parameters with -their confidence intervals?</p></dd> - - -<dt>cores</dt> -<dd><p>The number of cores to be used for multicore processing. -On Windows machines, cores > 1 is currently not supported.</p></dd> - - -<dt>rel_tol</dt> -<dd><p>If the method is 'profile', what should be the accuracy -of the lower and upper bounds, relative to the estimate obtained from -the quadratic method?</p></dd> - - -<dt>quiet</dt> -<dd><p>Should we suppress the message "Profiling the likelihood"</p></dd> - - -<dt>...</dt> -<dd><p>Not used</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A matrix with columns giving lower and upper confidence limits for -each parameter.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Bates DM and Watts GW (1988) Nonlinear regression analysis & its applications</p> -<p>Pawitan Y (2013) In all likelihood - Statistical modelling and -inference using likelihood. Clarendon Press, Oxford.</p> -<p>Venzon DJ and Moolgavkar SH (1988) A Method for Computing -Profile-Likelihood Based Confidence Intervals, Applied Statistics, 37, -87–94.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 71.8242430 93.1600766</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.2109541 0.4440528</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.9778868 7.3681380</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f</span>, method <span class="op">=</span> <span class="st">"profile"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 73.0641834 92.1392181</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.2170293 0.4235348</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.1307772 8.0628314</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Set the number of cores for the profiling method for further examples</span></span></span> -<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"NOT_CRAN"</span><span class="op">)</span>, <span class="st">"true"</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">n_cores</span> <span class="op"><-</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span> <span class="op">-</span> <span class="fl">1</span></span></span> -<span class="r-in"><span><span class="op">}</span> <span class="kw">else</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">n_cores</span> <span class="op"><-</span> <span class="fl">1</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.getenv.html" class="external-link">Sys.getenv</a></span><span class="op">(</span><span class="st">"TRAVIS"</span><span class="op">)</span> <span class="op">!=</span> <span class="st">""</span><span class="op">)</span> <span class="va">n_cores</span> <span class="op">=</span> <span class="fl">1</span></span></span> -<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="va">n_cores</span> <span class="op">=</span> <span class="fl">1</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"min"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_d_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">ci_profile</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"profile"</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> -<span class="r-out co"><span class="r-pr">#></span> 1.183 0.000 1.182 </span> -<span class="r-in"><span><span class="co"># Using more cores does not save much time here, as parent_0 takes up most of the time</span></span></span> -<span class="r-in"><span><span class="co"># If we additionally exclude parent_0 (the confidence of which is often of</span></span></span> -<span class="r-in"><span><span class="co"># minor interest), we get a nice performance improvement if we use at least 4 cores</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">ci_profile_no_parent_0</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"profile"</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"k_parent_sink"</span>, <span class="st">"k_parent_m1"</span>, <span class="st">"k_m1_sink"</span>, <span class="st">"sigma"</span><span class="op">)</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> -<span class="r-out co"><span class="r-pr">#></span> 0.418 0.116 0.294 </span> -<span class="r-in"><span><span class="va">ci_profile</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.456003640 1.027703e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.040762501 5.549764e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046786482 5.500879e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.003892605 6.702778e-03</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.535612399 3.985263e+00</span> -<span class="r-in"><span><span class="va">ci_quadratic_transformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ci_quadratic_transformed</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403841640 1.027931e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.041033378 5.596269e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046777902 5.511931e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.004012217 6.897547e-03</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.854918e+00</span> -<span class="r-in"><span><span class="va">ci_quadratic_untransformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_1</span>, method <span class="op">=</span> <span class="st">"quadratic"</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ci_quadratic_untransformed</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403841645 102.79312449</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.040485331 0.05535491</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.046611582 0.05494364</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.003835483 0.00668582</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.85491806</span> -<span class="r-in"><span><span class="co"># Against the expectation based on Bates and Watts (1988), the confidence</span></span></span> -<span class="r-in"><span><span class="co"># intervals based on the internal parameter transformation are less</span></span></span> -<span class="r-in"><span><span class="co"># congruent with the likelihood based intervals. Note the superiority of the</span></span></span> -<span class="r-in"><span><span class="co"># interval based on the untransformed fit for k_m1_sink</span></span></span> -<span class="r-in"><span><span class="va">rel_diffs_transformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_transformed</span> <span class="op">-</span> <span class="va">ci_profile</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">rel_diffs_untransformed</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_untransformed</span> <span class="op">-</span> <span class="va">ci_profile</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">rel_diffs_transformed</span> <span class="op"><</span> <span class="va">rel_diffs_untransformed</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 FALSE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink TRUE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 TRUE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink FALSE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> sigma FALSE FALSE</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">signif</a></span><span class="op">(</span><span class="va">rel_diffs_transformed</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 0.000541 0.000222</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.006650 0.008380</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.000183 0.002010</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.030700 0.029100</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 0.055000 0.032700</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">signif</a></span><span class="op">(</span><span class="va">rel_diffs_untransformed</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 0.000541 0.000222</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.006800 0.002570</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.003740 0.001180</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.014700 0.002530</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 0.055000 0.032700</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Investigate a case with formation fractions</span></span></span> -<span class="r-in"><span><span class="va">f_d_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ci_profile_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"profile"</span>, cores <span class="op">=</span> <span class="va">n_cores</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Profiling the likelihood</span> -<span class="r-in"><span><span class="va">ci_profile_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.456003640 1.027703e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090911032 1.071578e-01</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.003892606 6.702775e-03</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.471328495 5.611550e-01</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.535612399 3.985263e+00</span> -<span class="r-in"><span><span class="va">ci_quadratic_transformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ci_quadratic_transformed_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403833578 102.79311649</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090823771 0.10725430</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.004012219 0.00689755</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.469118824 0.55959615</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.85491806</span> -<span class="r-in"><span><span class="va">ci_quadratic_untransformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_d_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ci_quadratic_untransformed_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.403833583 1.027931e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.090491913 1.069035e-01</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.003835485 6.685823e-03</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.469113477 5.598387e-01</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.396089689 3.854918e+00</span> -<span class="r-in"><span><span class="va">rel_diffs_transformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_transformed_ff</span> <span class="op">-</span> <span class="va">ci_profile_ff</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile_ff</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">rel_diffs_untransformed_ff</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">abs</a></span><span class="op">(</span><span class="op">(</span><span class="va">ci_quadratic_untransformed_ff</span> <span class="op">-</span> <span class="va">ci_profile_ff</span><span class="op">)</span><span class="op">/</span><span class="va">ci_profile_ff</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># While the confidence interval for the parent rate constant is closer to</span></span></span> -<span class="r-in"><span><span class="co"># the profile based interval when using the internal parameter</span></span></span> -<span class="r-in"><span><span class="co"># transformation, the interval for the metabolite rate constant is 'better</span></span></span> -<span class="r-in"><span><span class="co"># without internal parameter transformation.</span></span></span> -<span class="r-in"><span><span class="va">rel_diffs_transformed_ff</span> <span class="op"><</span> <span class="va">rel_diffs_untransformed_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 FALSE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent TRUE TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 FALSE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 TRUE FALSE</span> -<span class="r-out co"><span class="r-pr">#></span> sigma TRUE FALSE</span> -<span class="r-in"><span><span class="va">rel_diffs_transformed_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 0.0005408690 0.0002217233</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0009598532 0.0009001864</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0307283041 0.0290588361</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.0046881769 0.0027780063</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 0.0550252516 0.0327066836</span> -<span class="r-in"><span><span class="va">rel_diffs_untransformed_ff</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 0.0005408689 0.0002217232</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0046102156 0.0023732281</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0146740690 0.0025291820</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.0046995211 0.0023457712</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 0.0550252516 0.0327066836</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The profiling for the following fit does not finish in a reasonable time,</span></span></span> -<span class="r-in"><span><span class="co"># therefore we use the quadratic approximation</span></span></span> -<span class="r-in"><span><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">DFOP_par_c</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span></span> -<span class="r-in"><span><span class="va">f_tc_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>, <span class="va">DFOP_par_c</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span></span> -<span class="r-in"><span> error_model_algorithm <span class="op">=</span> <span class="st">"direct"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_tc_2</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 94.596039609 106.19954892</span> -<span class="r-out co"><span class="r-pr">#></span> k_M1 0.037605368 0.04490762</span> -<span class="r-out co"><span class="r-pr">#></span> k_M2 0.008568731 0.01087676</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.021462489 0.62023882</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 0.015165617 0.37975348</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.273897348 0.33388101</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.018614554 0.02250378</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.671943411 0.73583305</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.251283495 0.83992077</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.040411024 0.07662008</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/confint.html" class="external-link">confint</a></span><span class="op">(</span><span class="va">f_tc_2</span>, <span class="st">"parent_0"</span>, method <span class="op">=</span> <span class="st">"quadratic"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 2.5% 97.5%</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 94.59604 106.1995</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/convergence.html b/docs/dev/reference/convergence.html deleted file mode 100644 index e9fac3bb..00000000 --- a/docs/dev/reference/convergence.html +++ /dev/null @@ -1,163 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Method to get 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-<span><span class="fu">convergence</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for convergence.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The object to investigate</p></dd> - - -<dt>...</dt> -<dd><p>For potential future extensions</p></dd> - - -<dt>x</dt> -<dd><p>The object to be printed</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>For <a href="mkinfit.html">mkinfit</a> objects, a character vector containing -For <a href="mmkin.html">mmkin</a> objects, an object of class 'convergence.mmkin' with a -suitable printing method.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span></span> -<span class="r-in"><span> <span class="st">"FOCUS B"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">convergence</span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model FOCUS A FOCUS B</span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 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class="op">(</span><span class="va">spec</span>, use_of_ff <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"min"</span>, <span class="st">"max"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>spec</dt> -<dd><p>List of model specifications as contained in mkinmod objects</p></dd> - - -<dt>use_of_ff</dt> -<dd><p>Minimum or maximum use of formation fractions</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Degradation function to be attached to mkinmod objects</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># to avoid warnings</span></span></span> -<span class="r-in"><span><span class="va">fit_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> analytical <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> deSolve <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> replications <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Loading required package: rbenchmark</span> -<span class="r-out co"><span class="r-pr">#></span> test replications elapsed relative user.self sys.self user.child</span> -<span class="r-out co"><span class="r-pr">#></span> 1 analytical 2 0.235 1.000 0.235 0 0</span> -<span class="r-out co"><span class="r-pr">#></span> 2 deSolve 2 0.294 1.251 0.294 0 0</span> -<span class="r-out co"><span class="r-pr">#></span> sys.child</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0</span> -<span class="r-in"><span> <span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> analytical <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"analytical"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> deSolve <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">FOCUS_D</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> replications <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> test replications elapsed relative user.self sys.self user.child</span> -<span class="r-out co"><span class="r-pr">#></span> 1 analytical 2 0.374 1.000 0.374 0 0</span> -<span class="r-out co"><span class="r-pr">#></span> 2 deSolve 2 0.527 1.409 0.526 0 0</span> -<span class="r-out co"><span class="r-pr">#></span> sys.child</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - 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Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - 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</li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/dimethenamid_2018.R" class="external-link"><code>R/dimethenamid_2018.R</code></a></small> - <div class="hidden name"><code>dimethenamid_2018.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The datasets were extracted from the active substance evaluation dossier -published by EFSA. Kinetic evaluations shown for these datasets are intended -to illustrate and advance kinetic modelling. The fact that these data and -some results are shown here does not imply a license to use them in the -context of pesticide registrations, as the use of the data may be -constrained by data protection regulations.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">dimethenamid_2018</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>An <a href="mkindsg.html">mkindsg</a> object grouping seven datasets with some meta information</p> - </div> - <div id="source"> - <h2>Source</h2> - <p>Rapporteur Member State Germany, Co-Rapporteur Member State Bulgaria (2018) -Renewal Assessment Report Dimethenamid-P Volume 3 - B.8 Environmental fate and behaviour -Rev. 2 - November 2017 -<a href="https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716" class="external-link">https://open.efsa.europa.eu/study-inventory/EFSA-Q-2014-00716</a></p> - </div> - <div id="details"> - <h2>Details</h2> - <p>The R code used to create this data object is installed with this package -in the 'dataset_generation' directory. In the code, page numbers are given for -specific pieces of information in the comments.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 7 mkinds objects</span> -<span class="r-out co"><span class="r-pr">#></span> Title $title: Aerobic soil degradation data on dimethenamid-P from the EU assessment in 2018 </span> -<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> -<span class="r-out co"><span class="r-pr">#></span> DMTAP M23 M27 M31 DMTA </span> -<span class="r-out co"><span class="r-pr">#></span> 3 7 7 7 4 </span> -<span class="r-out co"><span class="r-pr">#></span> Time normalisation factors $f_time_norm:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1.0000000 0.9706477 1.2284784 1.2284784 0.6233856 0.7678922 0.6733938</span> -<span class="r-out co"><span class="r-pr">#></span> Meta information $meta:</span> -<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type rel_moisture</span> -<span class="r-out co"><span class="r-pr">#></span> Calke Unsworth 2014 Sandy loam pF2 1.00</span> -<span class="r-out co"><span class="r-pr">#></span> Borstel Staudenmaier 2009 Sand pF1 0.50</span> -<span class="r-out co"><span class="r-pr">#></span> Elliot 1 Wendt 1997 Clay loam pF2.5 0.75</span> -<span class="r-out co"><span class="r-pr">#></span> Elliot 2 Wendt 1997 Clay loam pF2.5 0.75</span> -<span class="r-out co"><span class="r-pr">#></span> Flaach König 1996 Sandy clay loam pF1 0.40</span> -<span class="r-out co"><span class="r-pr">#></span> BBA 2.2 König 1995 Loamy sand pF1 0.40</span> -<span class="r-out co"><span class="r-pr">#></span> BBA 2.3 König 1995 Sandy loam pF1 0.40</span> -<span class="r-out co"><span class="r-pr">#></span> study_ref_moisture temperature</span> -<span class="r-out co"><span class="r-pr">#></span> Calke NA 20</span> -<span class="r-out co"><span class="r-pr">#></span> Borstel 23.00 20</span> -<span class="r-out co"><span class="r-pr">#></span> Elliot 1 33.37 23</span> -<span class="r-out co"><span class="r-pr">#></span> Elliot 2 33.37 23</span> -<span class="r-out co"><span class="r-pr">#></span> Flaach NA 20</span> -<span class="r-out co"><span class="r-pr">#></span> BBA 2.2 NA 20</span> -<span class="r-out co"><span class="r-pr">#></span> BBA 2.3 NA 20</span> -<span class="r-in"><span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># We don't use DFOP for the parent compound, as this gives numerical</span></span></span> -<span class="r-in"><span><span class="co"># instabilities in the fits</span></span></span> -<span class="r-in"><span><span class="va">sfo_sfo3p</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> DMTA <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M23"</span>, <span class="st">"M27"</span>, <span class="st">"M31"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M23 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M27 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M31 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M27"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_sfo_sfo3p_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO3+"</span> <span class="op">=</span> <span class="va">sfo_sfo3p</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">dmta_sfo_sfo3p_tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model Calke Borstel Flaach BBA 2.2 BBA 2.3 Elliot</span> -<span class="r-out co"><span class="r-pr">#></span> SFO-SFO3+ OK OK OK OK OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span><span class="co"># The default (test_log_parms = FALSE) gives an undue</span></span></span> -<span class="r-in"><span><span class="co"># influence of ill-defined rate constants that have</span></span></span> -<span class="r-in"><span><span class="co"># extremely small values:</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="mixed.html">mixed</a></span><span class="op">(</span><span class="va">dmta_sfo_sfo3p_tc</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># If we disregards ill-defined rate constants, the results</span></span></span> -<span class="r-in"><span><span class="co"># look more plausible, but the truth is likely to be in</span></span></span> -<span class="r-in"><span><span class="co"># between these variants</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="mixed.html">mixed</a></span><span class="op">(</span><span class="va">dmta_sfo_sfo3p_tc</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="dimethenamid_2018-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># We can also specify a default value for the failing</span></span></span> -<span class="r-in"><span><span class="co"># log parameters, to mimic FOCUS guidance</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="mixed.html">mixed</a></span><span class="op">(</span><span class="va">dmta_sfo_sfo3p_tc</span><span class="op">)</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>,</span></span> -<span class="r-in"><span> default_log_parms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span><span class="op">/</span><span class="fl">1000</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># As these attempts are not satisfying, we use nonlinear mixed-effects models</span></span></span> -<span class="r-in"><span><span class="co"># f_dmta_nlme_tc <- nlme(dmta_sfo_sfo3p_tc)</span></span></span> -<span class="r-in"><span><span class="co"># nlme reaches maxIter = 50 without convergence</span></span></span> -<span class="r-in"><span><span class="va">f_dmta_saem_tc</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">dmta_sfo_sfo3p_tc</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># I am commenting out the convergence plot as rendering them</span></span></span> -<span class="r-in"><span><span class="co"># with pkgdown fails (at least without further tweaks to the</span></span></span> -<span class="r-in"><span><span class="co"># graphics device used)</span></span></span> -<span class="r-in"><span><span class="co">#saemix::plot(f_dmta_saem_tc$so, plot.type = "convergence")</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_dmta_saem_tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> saemix version used for fitting: 3.2 </span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:30:03 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:30:03 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_DMTA/dt = - k_DMTA * DMTA</span> -<span class="r-out co"><span class="r-pr">#></span> d_M23/dt = + f_DMTA_to_M23 * k_DMTA * DMTA - k_M23 * M23</span> -<span class="r-out co"><span class="r-pr">#></span> d_M27/dt = + f_DMTA_to_M27 * k_DMTA * DMTA - k_M27 * M27 + k_M31 * M31</span> -<span class="r-out co"><span class="r-pr">#></span> d_M31/dt = + f_DMTA_to_M31 * k_DMTA * DMTA - k_M31 * M31</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 563 observations of 4 variable(s) grouped in 6 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type deSolve </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 304.528 s</span> -<span class="r-out co"><span class="r-pr">#></span> Using 300, 100 iterations and 9 chains</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for degradation parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 log_k_DMTA log_k_M23 log_k_M27 log_k_M31 f_DMTA_ilr_1 </span> -<span class="r-out co"><span class="r-pr">#></span> 95.5662 -2.9048 -3.8130 -4.1600 -4.1486 0.1341 </span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 f_DMTA_ilr_3 </span> -<span class="r-out co"><span class="r-pr">#></span> 0.1385 -1.6700 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for random effects (square root of initial entries in omega):</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 log_k_DMTA log_k_M23 log_k_M27 log_k_M31 f_DMTA_ilr_1</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 4.802 0.0000 0.0000 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_DMTA 0.000 0.9834 0.0000 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M23 0.000 0.0000 0.6983 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M27 0.000 0.0000 0.0000 1.028 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M31 0.000 0.0000 0.0000 0.000 0.9841 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_1 0.000 0.0000 0.0000 0.000 0.0000 0.7185</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 0.000 0.0000 0.0000 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 0.000 0.0000 0.0000 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 f_DMTA_ilr_3</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_DMTA 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M23 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M27 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M31 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_1 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 0.7378 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 0.0000 0.4451</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for error model parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 b.1 </span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood computed by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 2276 2273 -1120</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 88.3192 83.8656 92.7729</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_DMTA -3.0530 -3.5686 -2.5373</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -4.0620 -4.9202 -3.2038</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -3.8633 -4.2668 -3.4598</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -3.9731 -4.4763 -3.4699</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_1 0.1346 -0.2150 0.4841</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 0.1449 -0.2593 0.5491</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 -1.3882 -1.7011 -1.0753</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.9156 0.8217 1.0095</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.1383 0.1216 0.1550</span> -<span class="r-out co"><span class="r-pr">#></span> SD.DMTA_0 3.7280 -0.6949 8.1508</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_DMTA 0.6431 0.2781 1.0080</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M23 1.0096 0.3782 1.6409</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M27 0.4583 0.1541 0.7625</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M31 0.5738 0.1942 0.9533</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_1 0.4119 0.1528 0.6709</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_2 0.4780 0.1806 0.7754</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_3 0.3657 0.1383 0.5931</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 l__DMTA lg__M23 lg__M27 lg__M31 f_DMTA__1 f_DMTA__2</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_DMTA 0.0303 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M23 -0.0229 -0.0032 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M27 -0.0372 -0.0049 0.0041 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M31 -0.0245 -0.0032 0.0022 0.0815 </span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_1 -0.0046 -0.0006 0.0415 -0.0433 0.0324 </span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_2 -0.0008 -0.0002 0.0214 -0.0267 -0.0893 -0.0361 </span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_ilr_3 -0.1755 -0.0135 0.0423 0.0775 0.0377 -0.0066 0.0060 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> SD.DMTA_0 3.7280 -0.6949 8.1508</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_DMTA 0.6431 0.2781 1.0080</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M23 1.0096 0.3782 1.6409</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M27 0.4583 0.1541 0.7625</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_M31 0.5738 0.1942 0.9533</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_1 0.4119 0.1528 0.6709</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_2 0.4780 0.1806 0.7754</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_DMTA_ilr_3 0.3657 0.1383 0.5931</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.9156 0.8217 1.009</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.1383 0.1216 0.155</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_0 88.31924 83.865625 92.77286</span> -<span class="r-out co"><span class="r-pr">#></span> k_DMTA 0.04722 0.028196 0.07908</span> -<span class="r-out co"><span class="r-pr">#></span> k_M23 0.01721 0.007298 0.04061</span> -<span class="r-out co"><span class="r-pr">#></span> k_M27 0.02100 0.014027 0.03144</span> -<span class="r-out co"><span class="r-pr">#></span> k_M31 0.01882 0.011375 0.03112</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M23 0.14608 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M27 0.12077 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_DMTA_to_M31 0.11123 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_M23 0.1461</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_M27 0.1208</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_M31 0.1112</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA_sink 0.6219</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> DMTA 14.68 48.76</span> -<span class="r-out co"><span class="r-pr">#></span> M23 40.27 133.76</span> -<span class="r-out co"><span class="r-pr">#></span> M27 33.01 109.65</span> -<span class="r-out co"><span class="r-pr">#></span> M31 36.84 122.38</span> -<span class="r-in"><span><span class="co"># As the confidence interval for the random effects of DMTA_0</span></span></span> -<span class="r-in"><span><span class="co"># includes zero, we could try an alternative model without</span></span></span> -<span class="r-in"><span><span class="co"># such random effects</span></span></span> -<span class="r-in"><span><span class="co"># f_dmta_saem_tc_2 <- saem(dmta_sfo_sfo3p_tc,</span></span></span> -<span class="r-in"><span><span class="co"># covariance.model = diag(c(0, rep(1, 7))))</span></span></span> -<span class="r-in"><span><span class="co"># saemix::plot(f_dmta_saem_tc_2$so, plot.type = "convergence")</span></span></span> -<span class="r-in"><span><span class="co"># This does not perform better judged by AIC and BIC</span></span></span> -<span class="r-in"><span><span class="co"># saemix::compare.saemix(f_dmta_saem_tc$so, f_dmta_saem_tc_2$so)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/ds_mixed-1.png b/docs/dev/reference/ds_mixed-1.png Binary files differdeleted file mode 100644 index d8505ffd..00000000 --- a/docs/dev/reference/ds_mixed-1.png +++ /dev/null diff --git a/docs/dev/reference/ds_mixed.html b/docs/dev/reference/ds_mixed.html deleted file mode 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class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Synthetic data for hierarchical kinetic degradation models</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/ds_mixed.R" class="external-link"><code>R/ds_mixed.R</code></a></small> - <div class="hidden name"><code>ds_mixed.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The R code used to create this data object is installed with this package in -the 'dataset_generation' directory.</p> - </div> - - - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">sfo_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">ds_sfo</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">15</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">sfo_saem</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">sfo_mmkin</span>, no_random_effect <span class="op">=</span> <span class="st">"parent_0"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">sfo_saem</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="ds_mixed-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># This is the code used to generate the datasets</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/readLines.html" class="external-link">readLines</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/system.file.html" class="external-link">system.file</a></span><span class="op">(</span><span class="st">"dataset_generation/ds_mixed.R"</span>, package <span class="op">=</span> <span class="st">"mkin"</span><span class="op">)</span><span class="op">)</span>, sep <span class="op">=</span> <span class="st">"\n"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> # Synthetic data for hierarchical kinetic models</span> -<span class="r-out co"><span class="r-pr">#></span> # Refactored version of the code previously in tests/testthat/setup_script.R</span> -<span class="r-out co"><span class="r-pr">#></span> # The number of datasets was 3 for FOMC, and 10 for HS in that script, now it</span> -<span class="r-out co"><span class="r-pr">#></span> # is always 15 for consistency</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> library(mkin) # We use mkinmod and mkinpredict</span> -<span class="r-out co"><span class="r-pr">#></span> sampling_times = c(0, 1, 3, 7, 14, 28, 60, 90, 120)</span> -<span class="r-out co"><span class="r-pr">#></span> n <- 15</span> -<span class="r-out co"><span class="r-pr">#></span> log_sd <- 0.3</span> -<span class="r-out co"><span class="r-pr">#></span> err_1 = list(const = 1, prop = 0.05)</span> -<span class="r-out co"><span class="r-pr">#></span> tc <- function(value) sigma_twocomp(value, err_1$const, err_1$prop)</span> -<span class="r-out co"><span class="r-pr">#></span> const <- function(value) 2</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> SFO <- mkinmod(parent = mkinsub("SFO"))</span> -<span class="r-out co"><span class="r-pr">#></span> sfo_pop <- list(parent_0 = 100, k_parent = 0.03)</span> -<span class="r-out co"><span class="r-pr">#></span> sfo_parms <- as.matrix(data.frame(</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent = rlnorm(n, log(sfo_pop$k_parent), log_sd)))</span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> ds_sfo <- lapply(1:n, function(i) {</span> -<span class="r-out co"><span class="r-pr">#></span> ds_mean <- mkinpredict(SFO, sfo_parms[i, ],</span> -<span class="r-out co"><span class="r-pr">#></span> c(parent = sfo_pop$parent_0), sampling_times)</span> -<span class="r-out co"><span class="r-pr">#></span> add_err(ds_mean, tc, n = 1)[[1]]</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_sfo, "pop") <- sfo_pop</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_sfo, "parms") <- sfo_parms</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC <- mkinmod(parent = mkinsub("FOMC"))</span> -<span class="r-out co"><span class="r-pr">#></span> fomc_pop <- list(parent_0 = 100, alpha = 2, beta = 8)</span> -<span class="r-out co"><span class="r-pr">#></span> fomc_parms <- as.matrix(data.frame(</span> -<span class="r-out co"><span class="r-pr">#></span> alpha = rlnorm(n, log(fomc_pop$alpha), 0.4),</span> -<span class="r-out co"><span class="r-pr">#></span> beta = rlnorm(n, log(fomc_pop$beta), 0.2)))</span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> ds_fomc <- lapply(1:n, function(i) {</span> -<span class="r-out co"><span class="r-pr">#></span> ds_mean <- mkinpredict(FOMC, fomc_parms[i, ],</span> -<span class="r-out co"><span class="r-pr">#></span> c(parent = fomc_pop$parent_0), sampling_times)</span> -<span class="r-out co"><span class="r-pr">#></span> add_err(ds_mean, tc, n = 1)[[1]]</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_fomc, "pop") <- fomc_pop</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_fomc, "parms") <- fomc_parms</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP <- mkinmod(parent = mkinsub("DFOP"))</span> -<span class="r-out co"><span class="r-pr">#></span> dfop_pop <- list(parent_0 = 100, k1 = 0.06, k2 = 0.015, g = 0.4)</span> -<span class="r-out co"><span class="r-pr">#></span> dfop_parms <- as.matrix(data.frame(</span> -<span class="r-out co"><span class="r-pr">#></span> k1 = rlnorm(n, log(dfop_pop$k1), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> k2 = rlnorm(n, log(dfop_pop$k2), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> g = plogis(rnorm(n, qlogis(dfop_pop$g), log_sd))))</span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> ds_dfop <- lapply(1:n, function(i) {</span> -<span class="r-out co"><span class="r-pr">#></span> ds_mean <- mkinpredict(DFOP, dfop_parms[i, ],</span> -<span class="r-out co"><span class="r-pr">#></span> c(parent = dfop_pop$parent_0), sampling_times)</span> -<span class="r-out co"><span class="r-pr">#></span> add_err(ds_mean, tc, n = 1)[[1]]</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_dfop, "pop") <- dfop_pop</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_dfop, "parms") <- dfop_parms</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> HS <- mkinmod(parent = mkinsub("HS"))</span> -<span class="r-out co"><span class="r-pr">#></span> hs_pop <- list(parent_0 = 100, k1 = 0.08, k2 = 0.01, tb = 15)</span> -<span class="r-out co"><span class="r-pr">#></span> hs_parms <- as.matrix(data.frame(</span> -<span class="r-out co"><span class="r-pr">#></span> k1 = rlnorm(n, log(hs_pop$k1), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> k2 = rlnorm(n, log(hs_pop$k2), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> tb = rlnorm(n, log(hs_pop$tb), 0.1)))</span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> ds_hs <- lapply(1:n, function(i) {</span> -<span class="r-out co"><span class="r-pr">#></span> ds_mean <- mkinpredict(HS, hs_parms[i, ],</span> -<span class="r-out co"><span class="r-pr">#></span> c(parent = hs_pop$parent_0), sampling_times)</span> -<span class="r-out co"><span class="r-pr">#></span> add_err(ds_mean, const, n = 1)[[1]]</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_hs, "pop") <- hs_pop</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_hs, "parms") <- hs_parms</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP_SFO <- mkinmod(</span> -<span class="r-out co"><span class="r-pr">#></span> parent = mkinsub("DFOP", "m1"),</span> -<span class="r-out co"><span class="r-pr">#></span> m1 = mkinsub("SFO"),</span> -<span class="r-out co"><span class="r-pr">#></span> quiet = TRUE)</span> -<span class="r-out co"><span class="r-pr">#></span> dfop_sfo_pop <- list(parent_0 = 100,</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 = 0.007, f_parent_to_m1 = 0.5,</span> -<span class="r-out co"><span class="r-pr">#></span> k1 = 0.1, k2 = 0.02, g = 0.5)</span> -<span class="r-out co"><span class="r-pr">#></span> dfop_sfo_parms <- as.matrix(data.frame(</span> -<span class="r-out co"><span class="r-pr">#></span> k1 = rlnorm(n, log(dfop_sfo_pop$k1), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> k2 = rlnorm(n, log(dfop_sfo_pop$k2), log_sd),</span> -<span class="r-out co"><span class="r-pr">#></span> g = plogis(rnorm(n, qlogis(dfop_sfo_pop$g), log_sd)),</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 = plogis(rnorm(n,</span> -<span class="r-out co"><span class="r-pr">#></span> qlogis(dfop_sfo_pop$f_parent_to_m1), log_sd)),</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 = rlnorm(n, log(dfop_sfo_pop$k_m1), log_sd)))</span> -<span class="r-out co"><span class="r-pr">#></span> ds_dfop_sfo_mean <- lapply(1:n,</span> -<span class="r-out co"><span class="r-pr">#></span> function(i) {</span> -<span class="r-out co"><span class="r-pr">#></span> mkinpredict(DFOP_SFO, dfop_sfo_parms[i, ],</span> -<span class="r-out co"><span class="r-pr">#></span> c(parent = dfop_sfo_pop$parent_0, m1 = 0), sampling_times)</span> -<span class="r-out co"><span class="r-pr">#></span> }</span> -<span class="r-out co"><span class="r-pr">#></span> )</span> -<span class="r-out co"><span class="r-pr">#></span> set.seed(123456)</span> -<span class="r-out co"><span class="r-pr">#></span> ds_dfop_sfo <- lapply(ds_dfop_sfo_mean, function(ds) {</span> -<span class="r-out co"><span class="r-pr">#></span> add_err(ds,</span> -<span class="r-out co"><span class="r-pr">#></span> sdfunc = function(value) sqrt(err_1$const^2 + value^2 * err_1$prop^2),</span> -<span class="r-out co"><span class="r-pr">#></span> n = 1, secondary = "m1")[[1]]</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_dfop_sfo, "pop") <- dfop_sfo_pop</span> -<span class="r-out co"><span class="r-pr">#></span> attr(ds_dfop_sfo, "parms") <- dfop_sfo_parms</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> #save(ds_sfo, ds_fomc, ds_dfop, ds_hs, ds_dfop_sfo, file = "data/ds_mixed.rda", version = 2)</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with 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If the SFORB model was specified -for one of the parents or metabolites, the Eigenvalues are returned. These -are equivalent to the rate constants of the DFOP model, but with the -advantage that the SFORB model can also be used for metabolites."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Function to calculate endpoints for further use from kinetic models fitted -with mkinfit</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/endpoints.R" class="external-link"><code>R/endpoints.R</code></a></small> - <div class="hidden name"><code>endpoints.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function calculates DT50 and DT90 values as well as formation fractions -from kinetic models fitted with mkinfit. If the SFORB model was specified -for one of the parents or metabolites, the Eigenvalues are returned. These -are equivalent to the rate constants of the DFOP model, but with the -advantage that the SFORB model can also be used for metabolites.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">endpoints</span><span class="op">(</span><span class="va">fit</span>, covariates <span class="op">=</span> <span class="cn">NULL</span>, covariate_quantile <span class="op">=</span> <span class="fl">0.5</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>fit</dt> -<dd><p>An object of class <a href="mkinfit.html">mkinfit</a>, <a href="nlme.mmkin.html">nlme.mmkin</a> or <a href="saem.html">saem.mmkin</a>, or -another object that has list components mkinmod containing an <a href="mkinmod.html">mkinmod</a> -degradation model, and two numeric vectors, bparms.optim and bparms.fixed, -that contain parameter values for that model.</p></dd> - - -<dt>covariates</dt> -<dd><p>Numeric vector with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantile'.</p></dd> - - -<dt>covariate_quantile</dt> -<dd><p>This argument only has an effect if the fitted -object has covariate models. If so, the default is to show endpoints -for the median of the covariate values (50th percentile).</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A list with a matrix of dissipation times named distimes, and, if -applicable, a vector of formation fractions named ff and, if the SFORB model -was in use, a vector of eigenvalues of these SFORB models, equivalent to -DFOP rate constants</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>Additional DT50 values are calculated from the FOMC DT90 and k1 and k2 from -HS and DFOP, as well as from Eigenvalues b1 and b2 of any SFORB models</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>The function is used internally by <a href="summary.mkinfit.html">summary.mkinfit</a>, -<a href="summary.nlme.mmkin.html">summary.nlme.mmkin</a> and <a href="summary.saem.mmkin.html">summary.saem.mmkin</a>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> -<span class="r-out co"><span class="r-pr">#></span> parent 1.785233 15.1479 4.559973</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 1.886925 21.25106 6.397207 1.508293 38.83438</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="va">fit_3</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFORB"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu">endpoints</span><span class="op">(</span><span class="va">fit_3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_free </span> -<span class="r-out co"><span class="r-pr">#></span> 1 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $SFORB</span> -<span class="r-out co"><span class="r-pr">#></span> parent_b1 parent_b2 parent_g </span> -<span class="r-out co"><span class="r-pr">#></span> 0.4595574 0.0178488 0.8539454 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_parent_b1 DT50_parent_b2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 1.886925 21.25106 6.397208 1.508293 38.83438</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so b/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so Binary files differdeleted file mode 100755 index a692256d..00000000 --- a/docs/dev/reference/example_analysis/dlls/sforb_sfo2.so +++ /dev/null diff --git a/docs/dev/reference/example_analysis/example_analysis.Rmd b/docs/dev/reference/example_analysis/example_analysis.Rmd deleted file mode 100644 index 38a6bd20..00000000 --- a/docs/dev/reference/example_analysis/example_analysis.Rmd +++ /dev/null @@ -1,314 +0,0 @@ ---- -title: "Hierarchical kinetic modelling of degradation data" -author: -date: -output: mkin::hierarchical_kinetics -geometry: margin=2cm ---- - -\clearpage - -# Setup - -```{r packages, cache = FALSE, message = FALSE} -library(mkin) -library(knitr) -library(saemix) -library(parallel) -library(readxl) -``` - -```{r n_cores, cache = FALSE} -n_cores <- detectCores() - -if (Sys.info()["sysname"] == "Windows") { - cl <- makePSOCKcluster(n_cores) -} else { - cl <- makeForkCluster(n_cores) -} -``` - -\clearpage - -# Introduction - -This report shows hierarchical kinetic modelling for ... -The data were obtained from ... - -```{r ds} -data_path <- system.file( - "testdata", "lambda-cyhalothrin_soil_efsa_2014.xlsx", - package = "mkin") -ds <- read_spreadsheet(data_path, valid_datasets = c(1:4, 7:13)) -covariates <- attr(ds, "covariates") -``` - -The covariate data are shown below. - -```{r results = "asis", dependson = "ds", echo = FALSE} -kable(covariates, caption = "Covariate data for all datasets") -``` - -\clearpage - -The datasets with the residue time series are shown in the tables below. Please -refer to the spreadsheet for details like data sources, treatment of values -below reporting limits and time step normalisation factors. - -```{r results = "asis", dependson = "ds", echo = FALSE} -for (ds_name in names(ds)) { - print( - kable(mkin_long_to_wide(ds[[ds_name]]), - caption = paste("Dataset", ds_name), - booktabs = TRUE, row.names = FALSE)) - cat("\n\\clearpage\n") -} -``` - -# Parent only evaluations - -The following code performs separate fits of the candidate degradation models -to all datasets using constant variance and the two-component error model. - -```{r parent-sep, dependson = "ds"} -parent_deg_mods <- c("SFO", "FOMC", "DFOP", "SFORB") -errmods <- c(const = "constant variance", tc = "two-component error") -parent_sep_const <- mmkin( - parent_deg_mods, ds, - error_model = "const", - cluster = cl, quiet = TRUE) -parent_sep_tc <- update(parent_sep_const, error_model = "tc") -``` - -To select the parent model, the corresponding hierarchical fits are performed below. - -```{r parent-mhmkin, dependson = "parent-sep"} -parent_mhmkin <- mhmkin(list(parent_sep_const, parent_sep_tc), cluster = cl) -status(parent_mhmkin) |> kable() -``` - -All fits terminate without errors (status OK). The check for ill-defined -parameters shows that not all random effect parameters can be robustly -quantified. - -```{r dependson = "parent_mhmkin"} -illparms(parent_mhmkin) |> kable() -``` - -Therefore, the fits are updated, excluding random effects that were -ill-defined according to the `illparms` function. The status of the fits -is checked. - -```{r parent-mhmkin-refined} -parent_mhmkin_refined <- update(parent_mhmkin, - no_random_effect = illparms(parent_mhmkin)) -status(parent_mhmkin_refined) |> kable() -``` - -Also, it is checked if the AIC values of the refined fits are actually smaller -than the AIC values of the original fits. - -```{r dependson = "parent-mhmkin-refined"} -(AIC(parent_mhmkin_refined) < AIC(parent_mhmkin)) |> kable() -``` - -From the refined fits, the most suitable model is selected using the AIC. - -```{r parent-best, dependson = "parent-mhmkin"} -aic_parent <- AIC(parent_mhmkin_refined) -min_aic <- which(aic_parent == min(aic_parent), arr.ind = TRUE) -best_degmod_parent <- rownames(aic_parent)[min_aic[1]] -best_errmod_parent <- colnames(aic_parent)[min_aic[2]] -anova(parent_mhmkin_refined) |> kable(digits = 1) -parent_best <- parent_mhmkin_refined[[best_degmod_parent, best_errmod_parent]] -``` - -Based on the AIC, the combination of the `r best_degmod_parent` degradation -model with the error model `r errmods[best_errmod_parent]` is identified to -be most suitable for the degradation of the parent. The check below -confirms that no ill-defined parameters remain for this combined model. - -```{r dependson = "parent-best"} -illparms(parent_best) -``` - -The corresponding fit is plotted below. - -```{r dependson = "parent-best"} -plot(parent_best) -``` -The fitted parameters, together with approximate confidence -intervals are listed below. - -```{r dependson = "parent-best"} -parms(parent_best, ci = TRUE) |> kable(digits = 3) -``` - -To investigate a potential covariate influence on degradation parameters, a -covariate model is added to the hierarchical model for each of the degradation -parameters with well-defined random effects. Also, a version with covariate -models for both of them is fitted. - -```{r parent-best-pH} -parent_best_pH_1 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_free ~ pH)) -parent_best_pH_2 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_bound_free ~ pH)) -parent_best_pH_3 <- update(parent_best, covariates = covariates, - covariate_models = list(log_k_lambda_free ~ pH, log_k_lambda_bound_free ~ pH)) -``` - -The resulting models are compared. - -```{r dependson = "parent-best-pH"} -anova(parent_best, parent_best_pH_1, parent_best_pH_2, parent_best_pH_3) |> - kable(digits = 1) -``` - -The model fit with the lowest AIC is the one with a pH correlation of the -desorption rate constant `k_lambda_bound_free`. Plot and parameter listing -of this fit are shown below. Also, it is confirmed that no ill-defined -variance parameters are found. - -```{r dependson = "parent-best-pH"} -plot(parent_best_pH_2) -``` - -```{r dependson = "parent-best-pH"} -illparms(parent_best_pH_2) -parms(parent_best_pH_2, ci = TRUE) |> kable(digits = 3) -``` - -\clearpage - -# Pathway fits - -As an example of a pathway fit, a model with SFORB for the parent compound and -parallel formation of two metabolites is set up. - -```{r path-1-degmod} -if (!dir.exists("dlls")) dir.create("dlls") - -m_sforb_sfo2 = mkinmod( - lambda = mkinsub("SFORB", to = c("c_V", "c_XV")), - c_V = mkinsub("SFO"), - c_XV = mkinsub("SFO"), - name = "sforb_sfo2", - dll_dir = "dlls", - overwrite = TRUE, quiet = TRUE -) -``` - -Separate evaluations of all datasets are performed with constant variance -and using two-component error. - -```{r path-1-sep, dependson = c("path-1-degmod", "ds")} -sforb_sep_const <- mmkin(list(sforb_path = m_sforb_sfo2), ds, - cluster = cl, quiet = TRUE) -sforb_sep_tc <- update(sforb_sep_const, error_model = "tc") -``` - -The separate fits with constant variance are plotted. - -```{r dependson = "path-1-sep", fig.height = 9} -plot(mixed(sforb_sep_const)) -``` - -The two corresponding hierarchical fits, with the random effects for the parent -degradation parameters excluded as discussed above, and including the covariate -model that was identified for the parent degradation, are attempted below. - -```{r path-1, dependson = "path-1-sep"} -path_1 <- mhmkin(list(sforb_sep_const, sforb_sep_tc), - no_random_effect = c("lambda_free_0", "log_k_lambda_free_bound"), - covariates = covariates, covariate_models = list(log_k_lambda_bound_free ~ pH), - cluster = cl) -``` - -```{r dependson = "path-1"} -status(path_1) |> kable() -``` - -The status information shows that both fits were successfully completed. - -```{r dependson = "path-1"} -anova(path_1) |> kable(digits = 1) -``` -Model comparison shows that the two-component error model provides a much -better fit. - -```{r dependson = "path-1"} -illparms(path_1[["sforb_path", "tc"]]) -``` - -Two ill-defined variance components are found. Therefore, the fit is -repeated with the corresponding random effects removed. - -```{r path-1-refined, dependson = "path-1"} -path_1_refined <- update(path_1[["sforb_path", "tc"]], - no_random_effect = c("lambda_free_0", "log_k_lambda_free_bound", - "log_k_c_XV", "f_lambda_ilr_2")) -``` - -The empty output of the illparms function indicates that there are no -ill-defined parameters remaining in the refined fit. - -```{r dependson = "path-1-refined"} -illparms(path_1_refined) -``` - -Below, the refined fit is plotted and the fitted parameters are shown together -with their 95% confidence intervals. - -```{r dependson = "path-1-refined", fig.height = 9} -plot(path_1_refined) -``` - -```{r dependson = "path-1-refined", fig.height = 9} -parms(path_1_refined, ci = TRUE) |> kable(digits = 3) -``` - -\clearpage - -# Appendix - -## Listings of initial parent fits - -```{r listings-parent, results = "asis", echo = FALSE, dependson = "parent_mhmkin"} -for (deg_mod in parent_deg_mods) { - for (err_mod in c("const", "tc")) { - caption <- paste("Hierarchical", deg_mod, "fit with", errmods[err_mod]) - tex_listing(parent_mhmkin[[deg_mod, err_mod]], caption) - } -} -``` - -## Listings of refined parent fits - -```{r listings-parent-refined, results = "asis", echo = FALSE, dependson = "parent_mhmkin_refined"} -for (deg_mod in parent_deg_mods) { - for (err_mod in c("const", "tc")) { - caption <- paste("Refined hierarchical", deg_mod, "fit with", errmods[err_mod]) - tex_listing(parent_mhmkin_refined[[deg_mod, err_mod]], caption) - } -} -``` - -## Listings of pathway fits - -```{r listings-path-1, results = "asis", echo = FALSE, dependson = "path-1-refined"} -tex_listing(path_1[["sforb_path", "const"]], - caption = "Hierarchical fit of SFORB-SFO2 with constant variance") -tex_listing(path_1[["sforb_path", "tc"]], - caption = "Hierarchical fit of SFORB-SFO2 with two-component error") -tex_listing(path_1_refined, - caption = "Refined hierarchical fit of SFORB-SFO2 with two-component error") -``` - -## Session info - -```{r echo = FALSE, cache = FALSE} -parallel::stopCluster(cl) -sessionInfo() -``` - diff --git a/docs/dev/reference/example_analysis/header.tex b/docs/dev/reference/example_analysis/header.tex deleted file mode 100644 index a2b7ce83..00000000 --- a/docs/dev/reference/example_analysis/header.tex +++ /dev/null @@ -1 +0,0 @@ -\definecolor{shadecolor}{RGB}{248,248,248} diff --git a/docs/dev/reference/example_analysis/skeleton.pdf b/docs/dev/reference/example_analysis/skeleton.pdf Binary files differdeleted file mode 100644 index 53c5fb31..00000000 --- a/docs/dev/reference/example_analysis/skeleton.pdf +++ /dev/null diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf Binary files differdeleted file mode 100644 index ab685d92..00000000 --- a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-11-1.pdf +++ /dev/null diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf Binary files differdeleted file mode 100644 index 5d88063b..00000000 --- a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-16-1.pdf +++ /dev/null diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf Binary files differdeleted file mode 100644 index 5e0d7b6f..00000000 --- a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-6-1.pdf +++ /dev/null diff --git a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf b/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf Binary files differdeleted file mode 100644 index eecd06a8..00000000 --- a/docs/dev/reference/example_analysis/skeleton_files/figure-latex/unnamed-chunk-9-1.pdf +++ /dev/null diff --git a/docs/dev/reference/experimental_data_for_UBA-1.png b/docs/dev/reference/experimental_data_for_UBA-1.png Binary files differdeleted file mode 100644 index 49e1c6c9..00000000 --- a/docs/dev/reference/experimental_data_for_UBA-1.png +++ /dev/null diff --git a/docs/dev/reference/experimental_data_for_UBA.html b/docs/dev/reference/experimental_data_for_UBA.html deleted file mode 100644 index 77ff6ce4..00000000 --- a/docs/dev/reference/experimental_data_for_UBA.html +++ /dev/null @@ -1,275 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Experimental datasets used for development and testing of error models — experimental_data_for_UBA_2019 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Experimental datasets used for development and testing of error models — experimental_data_for_UBA_2019"><meta property="og:description" content="The 12 datasets were extracted from active substance evaluation dossiers published - by EFSA. Kinetic evaluations shown for these datasets are intended to illustrate - and advance error model specifications. The fact that these data and some - results are shown here do not imply a license to use them in the context of - pesticide registrations, as the use of the data may be constrained by - data protection regulations. -Preprocessing of data was performed based on the recommendations of the FOCUS - kinetics workgroup (FOCUS, 2014) as described below. -Datasets 1 and 2 are from the Renewal Assessment Report (RAR) for imazamox - (France, 2015, p. 15). For setting values reported as zero, an LOQ of 0.1 - was assumed. Metabolite residues reported for day zero were added to the - parent compound residues. -Datasets 3 and 4 are from the Renewal Assessment Report (RAR) for isofetamid - (Belgium, 2014, p. 8) and show the data for two different radiolabels. For - dataset 4, the value given for the metabolite in the day zero sampling - in replicate B was added to the parent compound, following the respective - FOCUS recommendation. -Dataset 5 is from the Renewal Assessment Report (RAR) for ethofumesate - (Austria, 2015, p. 16). -Datasets 6 to 10 are from the Renewal Assessment Report (RAR) for glyphosate - (Germany, 2013, pages 8, 28, 50, 51). For the initial sampling, - the residues given for the metabolite were added to the parent - value, following the recommendation of the FOCUS kinetics workgroup. -Dataset 11 is from the Renewal Assessment Report (RAR) for 2,4-D - (Hellas, 2013, p. 644). Values reported as zero were set to NA, with - the exception of the day three sampling of metabolite A2, which was set - to one half of the LOD reported to be 1% AR. -Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl - (United Kingdom, 2014, p. 81)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Experimental datasets used for development and testing of error models</h1> - - <div class="hidden name"><code>experimental_data_for_UBA.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The 12 datasets were extracted from active substance evaluation dossiers published - by EFSA. Kinetic evaluations shown for these datasets are intended to illustrate - and advance error model specifications. The fact that these data and some - results are shown here do not imply a license to use them in the context of - pesticide registrations, as the use of the data may be constrained by - data protection regulations.</p> -<p>Preprocessing of data was performed based on the recommendations of the FOCUS - kinetics workgroup (FOCUS, 2014) as described below.</p> -<p>Datasets 1 and 2 are from the Renewal Assessment Report (RAR) for imazamox - (France, 2015, p. 15). For setting values reported as zero, an LOQ of 0.1 - was assumed. Metabolite residues reported for day zero were added to the - parent compound residues.</p> -<p>Datasets 3 and 4 are from the Renewal Assessment Report (RAR) for isofetamid - (Belgium, 2014, p. 8) and show the data for two different radiolabels. For - dataset 4, the value given for the metabolite in the day zero sampling - in replicate B was added to the parent compound, following the respective - FOCUS recommendation.</p> -<p>Dataset 5 is from the Renewal Assessment Report (RAR) for ethofumesate - (Austria, 2015, p. 16).</p> -<p>Datasets 6 to 10 are from the Renewal Assessment Report (RAR) for glyphosate - (Germany, 2013, pages 8, 28, 50, 51). For the initial sampling, - the residues given for the metabolite were added to the parent - value, following the recommendation of the FOCUS kinetics workgroup.</p> -<p>Dataset 11 is from the Renewal Assessment Report (RAR) for 2,4-D - (Hellas, 2013, p. 644). Values reported as zero were set to NA, with - the exception of the day three sampling of metabolite A2, which was set - to one half of the LOD reported to be 1% AR.</p> -<p>Dataset 12 is from the Renewal Assessment Report (RAR) for thifensulfuron-methyl - (United Kingdom, 2014, p. 81).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">experimental_data_for_UBA_2019</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A list containing twelve datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>, - each containing, among others, the following components</p><dl><dt><code>title</code></dt> -<dd><p>The name of the dataset, e.g. <code>Soil 1</code></p></dd> - - <dt><code>data</code></dt> -<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - - -<p>Austria (2015). Ethofumesate Renewal Assessment Report Volume 3 Annex B.8 (AS)</p> -<p>Belgium (2014). Isofetamid (IKF-5411) Draft Assessment Report Volume 3 Annex B.8 (AS)</p> -<p>France (2015). Imazamox Draft Renewal Assessment Report Volume 3 Annex B.8 (AS)</p> -<p>FOCUS (2014) “Generic guidance for Estimating Persistence and - Degradation Kinetics from Environmental Fate Studies on Pesticides in EU - Registration” Report of the FOCUS Work Group on Degradation Kinetics, - Version 1.1, 18 December 2014 - <a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> -<p>Germany (2013). Renewal Assessment Report Glyphosate Volume 3 Annex B.8: Environmental Fate - and Behaviour</p> -<p>Hellas (2013). Renewal Assessment Report 2,4-D Volume 3 Annex B.8: Fate and behaviour in the - environment</p> -<p>Ranke (2019) Documentation of results obtained for the error model expertise - written for the German Umweltbundesamt.</p> -<p>United Kingdom (2014). Thifensulfuron-methyl - Annex B.8 (Volume 3) to the Report and Proposed - Decision of the United Kingdom made to the European Commission under Regulation (EC) No. - 1141/2010 for renewal of an active substance</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Model definitions</span></span></span> -<span class="r-in"><span><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">sfo_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">dfop_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">d_1_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">2</span><span class="op">]</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">d_1_2</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Soil"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_1_2_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo_sfo</span><span class="op">)</span>, <span class="va">d_1_2</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_1_2_tc</span>, resplot <span class="op">=</span> <span class="st">"errmod"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="experimental_data_for_UBA-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/f_time_norm_focus.html b/docs/dev/reference/f_time_norm_focus.html deleted file mode 100644 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href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a 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</div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Normalisation factors for aerobic soil degradation according to FOCUS guidance</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/f_time_norm_focus.R" class="external-link"><code>R/f_time_norm_focus.R</code></a></small> - <div class="hidden name"><code>f_time_norm_focus.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Time step normalisation factors for aerobic soil degradation as described -in Appendix 8 to the FOCUS kinetics guidance (FOCUS 2014, p. 369).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for numeric</span></span> -<span><span class="fu">f_time_norm_focus</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> moisture <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> field_moisture <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> temperature <span class="op">=</span> <span class="va">object</span>,</span> -<span> Q10 <span class="op">=</span> <span class="fl">2.58</span>,</span> -<span> walker <span class="op">=</span> <span class="fl">0.7</span>,</span> -<span> f_na <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkindsg</span></span> -<span><span class="fu">f_time_norm_focus</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> study_moisture_ref_source <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"meta"</span>, <span class="st">"focus"</span><span class="op">)</span>,</span> -<span> Q10 <span class="op">=</span> <span class="fl">2.58</span>,</span> -<span> walker <span class="op">=</span> <span class="fl">0.7</span>,</span> -<span> f_na <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An object containing information used for the calculations</p></dd> - - -<dt>...</dt> -<dd><p>Currently not used</p></dd> - - -<dt>moisture</dt> -<dd><p>Numeric vector of moisture contents in \% w/w</p></dd> - - -<dt>field_moisture</dt> -<dd><p>Numeric vector of moisture contents at field capacity -(pF2) in \% w/w</p></dd> - - -<dt>temperature</dt> -<dd><p>Numeric vector of temperatures in °C</p></dd> - - -<dt>Q10</dt> -<dd><p>The Q10 value used for temperature normalisation</p></dd> - - -<dt>walker</dt> -<dd><p>The Walker exponent used for moisture normalisation</p></dd> - - -<dt>f_na</dt> -<dd><p>The factor to use for NA values. If set to NA, only factors -for complete cases will be returned.</p></dd> - - -<dt>study_moisture_ref_source</dt> -<dd><p>Source for the reference value -used to calculate the study moisture. If 'auto', preference is given -to a reference moisture given in the meta information, otherwise -the focus soil moisture for the soil class is used</p></dd> - -</dl></div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="focus_soil_moisture.html">focus_soil_moisture</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="fl">25</span>, <span class="fl">20</span>, <span class="fl">25</span><span class="op">)</span> <span class="co"># 1.37, compare FOCUS 2014 p. 184</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1.373956</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">D24_2014</span><span class="op">$</span><span class="va">meta</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> study usda_soil_type study_moisture_ref_type</span> -<span class="r-out co"><span class="r-pr">#></span> Mississippi Cohen 1991 Silt loam <NA></span> -<span class="r-out co"><span class="r-pr">#></span> Fayette Liu and Adelfinskaya 2011 Silt loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G Liu and Adelfinskaya 2011 Loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> Site E1 Liu and Adelfinskaya 2011 Loam pF1</span> -<span class="r-out co"><span class="r-pr">#></span> Site I2 Liu and Adelfinskaya 2011 Loamy sand pF1</span> -<span class="r-out co"><span class="r-pr">#></span> rel_moisture temperature</span> -<span class="r-out co"><span class="r-pr">#></span> Mississippi NA 25</span> -<span class="r-out co"><span class="r-pr">#></span> Fayette 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> RefSol 03-G 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> Site E1 0.5 20</span> -<span class="r-out co"><span class="r-pr">#></span> Site I2 0.5 20</span> -<span class="r-in"><span><span class="co"># No moisture normalisation in the first dataset, so we use f_na = 1 to get</span></span></span> -<span class="r-in"><span><span class="co"># temperature only normalisation as in the EU evaluation</span></span></span> -<span class="r-in"><span><span class="fu">f_time_norm_focus</span><span class="op">(</span><span class="va">D24_2014</span>, study_moisture_ref_source <span class="op">=</span> <span class="st">"focus"</span>, f_na <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> $f_time_norm was (re)set to normalised values</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/focus_soil_moisture.html b/docs/dev/reference/focus_soil_moisture.html deleted file mode 100644 index cb4a035a..00000000 --- a/docs/dev/reference/focus_soil_moisture.html +++ /dev/null @@ -1,170 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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The table assumes field capacity -corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/focus_soil_moisture.R" class="external-link"><code>R/focus_soil_moisture.R</code></a></small> - <div class="hidden name"><code>focus_soil_moisture.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The value were transcribed from p. 36. The table assumes field capacity -corresponds to pF2, MWHC to pF 1 and 1/3 bar to pF 2.5.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">focus_soil_moisture</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A matrix with upper case USDA soil classes as row names, and water tension -('pF1', 'pF2', 'pF 2.5') as column names</p> - </div> - <div id="source"> - <h2>Source</h2> - <p>Anonymous (2014) Generic Guidance for Tier 1 FOCUS Ground Water Assessment -Version 2.2, May 2014 <a href="https://esdac.jrc.ec.europa.eu/projects/ground-water" class="external-link">https://esdac.jrc.ec.europa.eu/projects/ground-water</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">focus_soil_moisture</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> pF1 pF2 pF2.5</span> -<span class="r-out co"><span class="r-pr">#></span> Sand 24 12 7</span> -<span class="r-out co"><span class="r-pr">#></span> Loamy sand 24 14 9</span> -<span class="r-out co"><span class="r-pr">#></span> Sandy loam 27 19 15</span> -<span class="r-out co"><span class="r-pr">#></span> Sandy clay loam 28 22 18</span> -<span class="r-out co"><span class="r-pr">#></span> Clay loam 32 28 25</span> -<span class="r-out co"><span class="r-pr">#></span> Loam 31 25 21</span> -<span class="r-out co"><span class="r-pr">#></span> Silt loam 32 26 21</span> -<span class="r-out co"><span class="r-pr">#></span> Silty clay loam 34 30 27</span> -<span class="r-out co"><span class="r-pr">#></span> Silt 31 27 21</span> -<span class="r-out co"><span class="r-pr">#></span> Sandy clay 41 35 31</span> -<span class="r-out co"><span class="r-pr">#></span> Silty clay 44 40 36</span> -<span class="r-out co"><span class="r-pr">#></span> Clay 53 48 43</span> -</code></pre></div> - 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</div> - - <div id="value"> - <h2>Value</h2> - - -<p>A function that was likely previously assigned from within -nlme.mmkin</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/hierarchical_kinetics.html b/docs/dev/reference/hierarchical_kinetics.html deleted file mode 100644 index 7ece90cc..00000000 --- a/docs/dev/reference/hierarchical_kinetics.html +++ /dev/null @@ -1,197 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Hierarchical kinetics template — hierarchical_kinetics • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Hierarchical kinetics template — hierarchical_kinetics"><meta property="og:description" content='R markdown format for setting up hierarchical kinetics based on a template -provided with the mkin package. This format is based on rmarkdown::pdf_document. -Chunk options are adapted. Echoing R code from code chunks and caching are -turned on per default. character for prepending output from code chunks is -set to the empty string, code tidying is off, figure alignment defaults to -centering, and positioning of figures is set to "H", which means that -figures will not move around in the document, but stay where the user -includes them.'><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Hierarchical kinetics template</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/hierarchical_kinetics.R" class="external-link"><code>R/hierarchical_kinetics.R</code></a></small> - <div class="hidden name"><code>hierarchical_kinetics.Rd</code></div> - </div> - - <div class="ref-description"> - <p>R markdown format for setting up hierarchical kinetics based on a template -provided with the mkin package. This format is based on <a href="https://pkgs.rstudio.com/rmarkdown/reference/pdf_document.html" class="external-link">rmarkdown::pdf_document</a>. -Chunk options are adapted. Echoing R code from code chunks and caching are -turned on per default. character for prepending output from code chunks is -set to the empty string, code tidying is off, figure alignment defaults to -centering, and positioning of figures is set to "H", which means that -figures will not move around in the document, but stay where the user -includes them.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">hierarchical_kinetics</span><span class="op">(</span><span class="va">...</span>, keep_tex <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>...</dt> -<dd><p>Arguments to <code><a href="https://pkgs.rstudio.com/rmarkdown/reference/pdf_document.html" class="external-link">rmarkdown::pdf_document</a></code></p></dd> - - -<dt>keep_tex</dt> -<dd><p>Keep the intermediate tex file used in the conversion to PDF</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>R Markdown output format to pass to -<code><a href="https://pkgs.rstudio.com/rmarkdown/reference/render.html" class="external-link">render</a></code></p> - - - </div> - <div id="details"> - <h2>Details</h2> - <p>The latter feature (positioning the figures with "H") depends on the LaTeX -package 'float'. In addition, the LaTeX package 'listing' is used in the -template for showing model fit summaries in the Appendix. This means that -the LaTeX packages 'float' and 'listing' need to be installed in the TeX -distribution used.</p> -<p>On Windows, the easiest way to achieve this (if no TeX distribution -is present before) is to install the 'tinytex' R package, to run -'tinytex::install_tinytex()' to get the basic tiny Tex distribution, -and then to run 'tinytex::tlmgr_install(c("float", "listing"))'.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/rstudio/rmarkdown" class="external-link">rmarkdown</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># The following is now commented out after the relase of v1.2.3 for the generation</span></span></span> -<span class="r-in"><span><span class="co"># of online docs, as the command creates a directory and opens an editor</span></span></span> -<span class="r-in"><span><span class="co">#draft("example_analysis.rmd", template = "hierarchical_kinetics", package = "mkin")</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/illparms.html b/docs/dev/reference/illparms.html deleted file mode 100644 index 7bf6c1fe..00000000 --- a/docs/dev/reference/illparms.html +++ /dev/null @@ -1,253 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Method to get the names of ill-defined parameters — illparms • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Method to get the names of ill-defined parameters — illparms"><meta property="og:description" content="The method for generalised nonlinear regression fits as obtained -with mkinfit and mmkin checks if the degradation parameters -pass the Wald test (in degradation kinetics often simply called t-test) for -significant difference from zero. 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For this test, the parameterisation -without parameter transformations is used.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">illparms</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu">illparms</span><span class="op">(</span><span class="va">object</span>, conf.level <span class="op">=</span> <span class="fl">0.95</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for illparms.mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">illparms</span><span class="op">(</span><span class="va">object</span>, conf.level <span class="op">=</span> <span class="fl">0.95</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for illparms.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu">illparms</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> conf.level <span class="op">=</span> <span class="fl">0.95</span>,</span> -<span> random <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> errmod <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> slopes <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for illparms.saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mhmkin</span></span> -<span><span class="fu">illparms</span><span class="op">(</span><span class="va">object</span>, conf.level <span class="op">=</span> <span class="fl">0.95</span>, random <span class="op">=</span> <span class="cn">TRUE</span>, errmod <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for illparms.mhmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The object to investigate</p></dd> - - -<dt>...</dt> -<dd><p>For potential future extensions</p></dd> - - -<dt>conf.level</dt> -<dd><p>The confidence level for checking p values</p></dd> - - -<dt>x</dt> -<dd><p>The object to be printed</p></dd> - - -<dt>random</dt> -<dd><p>For hierarchical fits, should random effects be tested?</p></dd> - - -<dt>errmod</dt> -<dd><p>For hierarchical fits, should error model parameters be -tested?</p></dd> - - -<dt>slopes</dt> -<dd><p>For hierarchical <a href="saem.html">saem</a> fits using saemix as backend, -should slope parameters in the covariate model(starting with 'beta_') be -tested?</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>For <a href="mkinfit.html">mkinfit</a> or <a href="saem.html">saem</a> objects, a character vector of parameter -names. For <a href="mmkin.html">mmkin</a> or <a href="mhmkin.html">mhmkin</a> objects, a matrix like object of class -'illparms.mmkin' or 'illparms.mhmkin'.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>The method for hierarchical model fits, also known as nonlinear -mixed-effects model fits as obtained with <a href="saem.html">saem</a> and <a href="mhmkin.html">mhmkin</a> -checks if any of the confidence intervals for the random -effects expressed as standard deviations include zero, and if -the confidence intervals for the error model parameters include -zero.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>All return objects have printing methods. For the single fits, printing -does not output anything in the case no ill-defined parameters are found.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_A</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">illparms</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] "parent_0" "alpha" "beta" "sigma" </span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span></span> -<span class="r-in"><span> <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">illparms</span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model FOCUS A FOCUS C</span> -<span class="r-out co"><span class="r-pr">#></span> SFO </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC parent_0, alpha, beta, sigma </span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - 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<div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">ilr</span><span class="op">(</span><span class="va">x</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">invilr</span><span class="op">(</span><span class="va">x</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>A numeric vector. Naturally, the forward transformation is only -sensible for vectors with all elements being greater than zero.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The result of the forward or backward transformation. The returned -components always sum to 1 for the case of the inverse log-ratio -transformation.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Peter Filzmoser, Karel Hron (2008) Outlier Detection for -Compositional Data Using Robust Methods. Math Geosci 40 233-248</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Another implementation can be found in R package -<code>robCompositions</code>.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>René Lehmann and Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Order matters</span></span></span> -<span class="r-in"><span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.1</span>, <span class="fl">1</span>, <span class="fl">10</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] -1.628174 -2.820079</span> -<span class="r-in"><span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10</span>, <span class="fl">1</span>, <span class="fl">0.1</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1.628174 2.820079</span> -<span class="r-in"><span><span class="co"># Equal entries give ilr transformations with zeros as elements</span></span></span> -<span class="r-in"><span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fl">3</span>, <span class="fl">3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0 0</span> -<span class="r-in"><span><span class="co"># Almost equal entries give small numbers</span></span></span> -<span class="r-in"><span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.3</span>, <span class="fl">0.4</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] -0.2034219 0.1174457</span> -<span class="r-in"><span><span class="co"># Only the ratio between the numbers counts, not their sum</span></span></span> -<span class="r-in"><span><span class="fu">invilr</span><span class="op">(</span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.7</span>, <span class="fl">0.29</span>, <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.70 0.29 0.01</span> -<span class="r-in"><span><span class="fu">invilr</span><span class="op">(</span><span class="fu">ilr</span><span class="op">(</span><span class="fl">2.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.7</span>, <span class="fl">0.29</span>, <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.70 0.29 0.01</span> -<span class="r-in"><span><span class="co"># Inverse transformation of larger numbers gives unequal elements</span></span></span> -<span class="r-in"><span><span class="fu">invilr</span><span class="op">(</span><span class="op">-</span><span class="fl">10</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 7.213536e-07 9.999993e-01</span> -<span class="r-in"><span><span class="fu">invilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>, <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 7.207415e-07 9.991507e-01 8.486044e-04</span> -<span class="r-in"><span><span class="co"># The sum of the elements of the inverse ilr is 1</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="fu">invilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>, <span class="fl">0</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 1</span> -<span class="r-in"><span><span class="co"># This is why we do not need all elements of the inverse transformation to go back:</span></span></span> -<span class="r-in"><span><span class="va">a</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.1</span>, <span class="fl">0.3</span>, <span class="fl">0.5</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">b</span> <span class="op"><-</span> <span class="fu">invilr</span><span class="op">(</span><span class="va">a</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">b</span><span class="op">)</span> <span class="co"># Four elements</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 4</span> -<span class="r-in"><span><span class="fu">ilr</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="va">b</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, <span class="fl">1</span> <span class="op">-</span> <span class="fu"><a href="https://rdrr.io/r/base/sum.html" class="external-link">sum</a></span><span class="op">(</span><span class="va">b</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span><span class="op">)</span><span class="op">)</span><span class="op">)</span> <span class="co"># Gives c(0.1, 0.3, 0.5)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.1 0.3 0.5</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/index.html b/docs/dev/reference/index.html deleted file mode 100644 index d1b789c3..00000000 --- a/docs/dev/reference/index.html +++ /dev/null @@ -1,528 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta 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type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.4</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="contents col-md-9"> - <div class="page-header"> - <h1>Reference</h1> - </div> - - <table class="ref-index"><colgroup><col class="alias"><col class="title"></colgroup><tbody><tr><th colspan="2"> - <h2 id="main-functions">Main functions <a href="#main-functions" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Essential functionality</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="mkinmod.html">mkinmod()</a></code> <code><a href="mkinmod.html">print(<i><mkinmod></i>)</a></code> <code><a href="mkinmod.html">mkinsub()</a></code> </p> - </td> - <td><p>Function to set up a kinetic model with one or more state variables</p></td> - </tr><tr><td> - <p><code><a href="mkinfit.html">mkinfit()</a></code> </p> - </td> - <td><p>Fit a kinetic model to data with one or more state variables</p></td> - </tr><tr><td> - <p><code><a href="mmkin.html">mmkin()</a></code> <code><a href="mmkin.html">print(<i><mmkin></i>)</a></code> </p> - </td> - <td><p>Fit one or more kinetic models with one or more state variables to one or -more datasets</p></td> - </tr><tr><td> - <p><code><a href="mhmkin.html">mhmkin()</a></code> <code><a href="mhmkin.html">`[`(<i><mhmkin></i>)</a></code> <code><a href="mhmkin.html">print(<i><mhmkin></i>)</a></code> </p> - </td> - <td><p>Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="generics">Generics <a href="#generics" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Generic functions introduced by the package</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="parms.html">parms()</a></code> </p> - </td> - <td><p>Extract model parameters</p></td> - </tr><tr><td> - <p><code><a href="status.html">status()</a></code> <code><a href="status.html">print(<i><status.mmkin></i>)</a></code> <code><a href="status.html">print(<i><status.mhmkin></i>)</a></code> </p> - </td> - <td><p>Method to get status information for fit array objects</p></td> - </tr><tr><td> - <p><code><a href="illparms.html">illparms()</a></code> <code><a href="illparms.html">print(<i><illparms.mkinfit></i>)</a></code> <code><a href="illparms.html">print(<i><illparms.mmkin></i>)</a></code> <code><a href="illparms.html">print(<i><illparms.saem.mmkin></i>)</a></code> <code><a href="illparms.html">print(<i><illparms.mhmkin></i>)</a></code> </p> - </td> - <td><p>Method to get the names of ill-defined parameters</p></td> - </tr><tr><td> - <p><code><a href="endpoints.html">endpoints()</a></code> </p> - </td> - <td><p>Function to calculate endpoints for further use from kinetic models fitted -with mkinfit</p></td> - </tr><tr><td> - <p><code><a href="aw.html">aw()</a></code> </p> - </td> - <td><p>Calculate Akaike weights for model averaging</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="show-results">Show results <a href="#show-results" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Functions working with mkinfit objects</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="plot.mkinfit.html">plot(<i><mkinfit></i>)</a></code> <code><a href="plot.mkinfit.html">plot_sep()</a></code> <code><a href="plot.mkinfit.html">plot_res()</a></code> <code><a href="plot.mkinfit.html">plot_err()</a></code> </p> - </td> - <td><p>Plot the observed data and the fitted model of an mkinfit object</p></td> - </tr><tr><td> - <p><code><a href="summary.mkinfit.html">summary(<i><mkinfit></i>)</a></code> <code><a href="summary.mkinfit.html">print(<i><summary.mkinfit></i>)</a></code> </p> - </td> - <td><p>Summary method for class "mkinfit"</p></td> - </tr><tr><td> - <p><code><a href="confint.mkinfit.html">confint(<i><mkinfit></i>)</a></code> </p> - </td> - <td><p>Confidence intervals for parameters of mkinfit objects</p></td> - </tr><tr><td> - <p><code><a href="update.mkinfit.html">update(<i><mkinfit></i>)</a></code> </p> - </td> - <td><p>Update an mkinfit model with different arguments</p></td> - </tr><tr><td> - <p><code><a href="lrtest.mkinfit.html">lrtest(<i><mkinfit></i>)</a></code> <code><a href="lrtest.mkinfit.html">lrtest(<i><mmkin></i>)</a></code> </p> - </td> - <td><p>Likelihood ratio test for mkinfit models</p></td> - </tr><tr><td> - <p><code><a href="loftest.html">loftest()</a></code> </p> - </td> - <td><p>Lack-of-fit test for models fitted to data with replicates</p></td> - </tr><tr><td> - <p><code><a href="mkinerrmin.html">mkinerrmin()</a></code> </p> - </td> - <td><p>Calculate the minimum error to assume in order to pass the variance test</p></td> - </tr><tr><td> - <p><code><a href="CAKE_export.html">CAKE_export()</a></code> </p> - </td> - <td><p>Export a list of datasets format to a CAKE study file</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="work-with-mmkin-objects">Work with mmkin objects <a href="#work-with-mmkin-objects" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Functions working with aggregated results</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="Extract.mmkin.html">`[`(<i><mmkin></i>)</a></code> </p> - </td> - <td><p>Subsetting method for mmkin objects</p></td> - </tr><tr><td> - <p><code><a href="plot.mmkin.html">plot(<i><mmkin></i>)</a></code> </p> - </td> - <td><p>Plot model fits (observed and fitted) and the residuals for a row or column -of an mmkin object</p></td> - </tr><tr><td> - <p><code><a href="AIC.mmkin.html">AIC(<i><mmkin></i>)</a></code> <code><a href="AIC.mmkin.html">BIC(<i><mmkin></i>)</a></code> </p> - </td> - <td><p>Calculate the AIC for a column of an mmkin object</p></td> - </tr><tr><td> - <p><code><a href="summary.mmkin.html">summary(<i><mmkin></i>)</a></code> <code><a href="summary.mmkin.html">print(<i><summary.mmkin></i>)</a></code> </p> - </td> - <td><p>Summary method for class "mmkin"</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="mixed-models">Mixed models <a href="#mixed-models" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Create and work with nonlinear hierarchical models</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="hierarchical_kinetics.html">hierarchical_kinetics()</a></code> </p> - </td> - <td><p>Hierarchical kinetics template</p></td> - </tr><tr><td> - <p><code><a href="read_spreadsheet.html">read_spreadsheet()</a></code> </p> - </td> - <td><p>Read datasets and relevant meta information from a spreadsheet file</p></td> - </tr><tr><td> - <p><code><a href="nlme.mmkin.html">nlme(<i><mmkin></i>)</a></code> <code><a href="nlme.mmkin.html">print(<i><nlme.mmkin></i>)</a></code> <code><a href="nlme.mmkin.html">update(<i><nlme.mmkin></i>)</a></code> </p> - </td> - <td><p>Create an nlme model for an mmkin row object</p></td> - </tr><tr><td> - <p><code><a href="saem.html">saem()</a></code> <code><a href="saem.html">print(<i><saem.mmkin></i>)</a></code> <code><a href="saem.html">saemix_model()</a></code> <code><a href="saem.html">saemix_data()</a></code> </p> - </td> - <td><p>Fit nonlinear mixed models with SAEM</p></td> - </tr><tr><td> - <p><code><a href="mhmkin.html">mhmkin()</a></code> <code><a href="mhmkin.html">`[`(<i><mhmkin></i>)</a></code> <code><a href="mhmkin.html">print(<i><mhmkin></i>)</a></code> </p> - </td> - <td><p>Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models</p></td> - </tr><tr><td> - <p><code><a href="plot.mixed.mmkin.html">plot(<i><mixed.mmkin></i>)</a></code> </p> - </td> - <td><p>Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object</p></td> - </tr><tr><td> - <p><code><a href="summary.nlme.mmkin.html">summary(<i><nlme.mmkin></i>)</a></code> <code><a href="summary.nlme.mmkin.html">print(<i><summary.nlme.mmkin></i>)</a></code> </p> - </td> - <td><p>Summary method for class "nlme.mmkin"</p></td> - </tr><tr><td> - <p><code><a href="summary.saem.mmkin.html">summary(<i><saem.mmkin></i>)</a></code> <code><a href="summary.saem.mmkin.html">print(<i><summary.saem.mmkin></i>)</a></code> </p> - </td> - <td><p>Summary method for class "saem.mmkin"</p></td> - </tr><tr><td> - <p><code><a href="anova.saem.mmkin.html">anova(<i><saem.mmkin></i>)</a></code> </p> - </td> - <td><p>Anova method for saem.mmkin objects</p></td> - </tr><tr><td> - <p><code><a href="logLik.saem.mmkin.html">logLik(<i><saem.mmkin></i>)</a></code> </p> - </td> - <td><p>logLik method for saem.mmkin objects</p></td> - </tr><tr><td> - <p><code><a href="nlme.html">nlme_function()</a></code> <code><a href="nlme.html">nlme_data()</a></code> </p> - </td> - <td><p>Helper functions to create nlme models from mmkin row objects</p></td> - </tr><tr><td> - <p><code><a href="get_deg_func.html">get_deg_func()</a></code> </p> - </td> - <td><p>Retrieve a degradation function from the mmkin namespace</p></td> - </tr><tr><td> - <p><code><a href="mixed.html">mixed()</a></code> <code><a href="mixed.html">print(<i><mixed.mmkin></i>)</a></code> </p> - </td> - <td><p>Create a mixed effects model from an mmkin row object</p></td> - </tr><tr><td> - <p><code><a href="reexports.html">reexports</a></code> <code><a href="reexports.html">intervals</a></code> <code><a href="reexports.html">lrtest</a></code> <code><a href="reexports.html">nlme</a></code> </p> - </td> - <td><p>Objects exported from other packages</p></td> - </tr><tr><td> - <p><code><a href="intervals.saem.mmkin.html">intervals(<i><saem.mmkin></i>)</a></code> </p> - </td> - <td><p>Confidence intervals for parameters in saem.mmkin objects</p></td> - </tr><tr><td> - <p><code><a href="multistart.html">multistart()</a></code> <code><a href="multistart.html">print(<i><multistart></i>)</a></code> <code><a href="multistart.html">best()</a></code> <code><a href="multistart.html">which.best()</a></code> </p> - </td> - <td><p>Perform a hierarchical model fit with multiple starting values</p></td> - </tr><tr><td> - <p><code><a href="llhist.html">llhist()</a></code> </p> - </td> - <td><p>Plot the distribution of log likelihoods from multistart objects</p></td> - </tr><tr><td> - <p><code><a href="parplot.html">parplot()</a></code> </p> - </td> - <td><p>Plot parameter variability of multistart objects</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="datasets-and-known-results">Datasets and known results <a href="#datasets-and-known-results" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="ds_mixed.html">ds_mixed</a></code> <code><a href="ds_mixed.html">ds_sfo</a></code> <code><a href="ds_mixed.html">ds_fomc</a></code> <code><a href="ds_mixed.html">ds_dfop</a></code> <code><a href="ds_mixed.html">ds_hs</a></code> <code><a href="ds_mixed.html">ds_dfop_sfo</a></code> </p> - </td> - <td><p>Synthetic data for hierarchical kinetic degradation models</p></td> - </tr><tr><td> - <p><code><a href="D24_2014.html">D24_2014</a></code> </p> - </td> - <td><p>Aerobic soil degradation data on 2,4-D from the EU assessment in 2014</p></td> - </tr><tr><td> - <p><code><a href="dimethenamid_2018.html">dimethenamid_2018</a></code> </p> - </td> - <td><p>Aerobic soil degradation data on dimethenamid and dimethenamid-P from the EU assessment in 2018</p></td> - </tr><tr><td> - <p><code><a href="FOCUS_2006_datasets.html">FOCUS_2006_A</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_B</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_C</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_D</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_E</a></code> <code><a href="FOCUS_2006_datasets.html">FOCUS_2006_F</a></code> </p> - </td> - <td><p>Datasets A to F from the FOCUS Kinetics report from 2006</p></td> - </tr><tr><td> - <p><code><a href="FOCUS_2006_SFO_ref_A_to_F.html">FOCUS_2006_SFO_ref_A_to_F</a></code> </p> - </td> - <td><p>Results of fitting the SFO model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr><td> - <p><code><a href="FOCUS_2006_FOMC_ref_A_to_F.html">FOCUS_2006_FOMC_ref_A_to_F</a></code> </p> - </td> - <td><p>Results of fitting the FOMC model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr><td> - <p><code><a href="FOCUS_2006_HS_ref_A_to_F.html">FOCUS_2006_HS_ref_A_to_F</a></code> </p> - </td> - <td><p>Results of fitting the HS model to Datasets A to F of FOCUS (2006)</p></td> - </tr><tr><td> - <p><code><a href="FOCUS_2006_DFOP_ref_A_to_B.html">FOCUS_2006_DFOP_ref_A_to_B</a></code> </p> - </td> - <td><p>Results of fitting the DFOP model to Datasets A to B of FOCUS (2006)</p></td> - </tr><tr><td> - <p><code><a href="NAFTA_SOP_2015.html">NAFTA_SOP_Appendix_B</a></code> <code><a href="NAFTA_SOP_2015.html">NAFTA_SOP_Appendix_D</a></code> </p> - </td> - <td><p>Example datasets from the NAFTA SOP published 2015</p></td> - </tr><tr><td> - <p><code><a href="NAFTA_SOP_Attachment.html">NAFTA_SOP_Attachment</a></code> </p> - </td> - <td><p>Example datasets from Attachment 1 to the NAFTA SOP published 2015</p></td> - </tr><tr><td> - <p><code><a href="mccall81_245T.html">mccall81_245T</a></code> </p> - </td> - <td><p>Datasets on aerobic soil metabolism of 2,4,5-T in six soils</p></td> - </tr><tr><td> - <p><code><a href="schaefer07_complex_case.html">schaefer07_complex_case</a></code> </p> - </td> - <td><p>Metabolism data set used for checking the software quality of KinGUI</p></td> - </tr><tr><td> - <p><code><a href="synthetic_data_for_UBA_2014.html">synthetic_data_for_UBA_2014</a></code> </p> - </td> - <td><p>Synthetic datasets for one parent compound with two metabolites</p></td> - </tr><tr><td> - <p><code><a href="experimental_data_for_UBA.html">experimental_data_for_UBA_2019</a></code> </p> - </td> - <td><p>Experimental datasets used for development and testing of error models</p></td> - </tr><tr><td> - <p><code><a href="test_data_from_UBA_2014.html">test_data_from_UBA_2014</a></code> </p> - </td> - <td><p>Three experimental datasets from two water sediment systems and one soil</p></td> - </tr><tr><td> - <p><code><a href="focus_soil_moisture.html">focus_soil_moisture</a></code> </p> - </td> - <td><p>FOCUS default values for soil moisture contents at field capacity, MWHC and 1/3 bar</p></td> - </tr><tr><td> - <p><code><a href="mkinds.html">print(<i><mkinds></i>)</a></code> </p> - </td> - <td><p>A dataset class for mkin</p></td> - </tr><tr><td> - <p><code><a href="mkindsg.html">print(<i><mkindsg></i>)</a></code> </p> - </td> - <td><p>A class for dataset groups for mkin</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="nafta-guidance">NAFTA guidance <a href="#nafta-guidance" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="nafta.html">nafta()</a></code> <code><a href="nafta.html">print(<i><nafta></i>)</a></code> </p> - </td> - <td><p>Evaluate parent kinetics using the NAFTA guidance</p></td> - </tr><tr><td> - <p><code><a href="plot.nafta.html">plot(<i><nafta></i>)</a></code> </p> - </td> - <td><p>Plot the results of the three models used in the NAFTA scheme.</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="utility-functions">Utility functions <a href="#utility-functions" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="summary_listing.html">summary_listing()</a></code> <code><a href="summary_listing.html">tex_listing()</a></code> <code><a href="summary_listing.html">html_listing()</a></code> </p> - </td> - <td><p>Display the output of a summary function according to the output format</p></td> - </tr><tr><td> - <p><code><a href="f_time_norm_focus.html">f_time_norm_focus()</a></code> </p> - </td> - <td><p>Normalisation factors for aerobic soil degradation according to FOCUS guidance</p></td> - </tr><tr><td> - <p><code><a href="set_nd_nq.html">set_nd_nq()</a></code> <code><a href="set_nd_nq.html">set_nd_nq_focus()</a></code> </p> - </td> - <td><p>Set non-detects and unquantified values in residue series without replicates</p></td> - </tr><tr><td> - <p><code><a href="max_twa_parent.html">max_twa_parent()</a></code> <code><a href="max_twa_parent.html">max_twa_sfo()</a></code> <code><a href="max_twa_parent.html">max_twa_fomc()</a></code> <code><a href="max_twa_parent.html">max_twa_dfop()</a></code> <code><a href="max_twa_parent.html">max_twa_hs()</a></code> </p> - </td> - <td><p>Function to calculate maximum time weighted average concentrations from -kinetic models fitted with mkinfit</p></td> - </tr><tr><td> - <p><code><a href="mkin_wide_to_long.html">mkin_wide_to_long()</a></code> </p> - </td> - <td><p>Convert a dataframe with observations over time into long format</p></td> - </tr><tr><td> - <p><code><a href="mkin_long_to_wide.html">mkin_long_to_wide()</a></code> </p> - </td> - <td><p>Convert a dataframe from long to wide format</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="helper-functions-mainly-used-internally">Helper functions mainly used internally <a href="#helper-functions-mainly-used-internally" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="mkinpredict.html">mkinpredict()</a></code> </p> - </td> - <td><p>Produce predictions from a kinetic model using specific parameters</p></td> - </tr><tr><td> - <p><code><a href="transform_odeparms.html">transform_odeparms()</a></code> <code><a href="transform_odeparms.html">backtransform_odeparms()</a></code> </p> - </td> - <td><p>Functions to transform and backtransform kinetic parameters for fitting</p></td> - </tr><tr><td> - <p><code><a href="ilr.html">ilr()</a></code> <code><a href="ilr.html">invilr()</a></code> </p> - </td> - <td><p>Function to perform isometric log-ratio transformation</p></td> - </tr><tr><td> - <p><code><a href="logLik.mkinfit.html">logLik(<i><mkinfit></i>)</a></code> </p> - </td> - <td><p>Calculated the log-likelihood of a fitted mkinfit object</p></td> - </tr><tr><td> - <p><code><a href="residuals.mkinfit.html">residuals(<i><mkinfit></i>)</a></code> </p> - </td> - <td><p>Extract residuals from an mkinfit model</p></td> - </tr><tr><td> - <p><code><a href="nobs.mkinfit.html">nobs(<i><mkinfit></i>)</a></code> </p> - </td> - <td><p>Number of observations on which an mkinfit object was fitted</p></td> - </tr><tr><td> - <p><code><a href="mkinresplot.html">mkinresplot()</a></code> </p> - </td> - <td><p>Function to plot residuals stored in an mkin object</p></td> - </tr><tr><td> - <p><code><a href="mkinparplot.html">mkinparplot()</a></code> </p> - </td> - <td><p>Function to plot the confidence intervals obtained using mkinfit</p></td> - </tr><tr><td> - <p><code><a href="mkinerrplot.html">mkinerrplot()</a></code> </p> - </td> - <td><p>Function to plot squared residuals and the error model for an mkin object</p></td> - </tr><tr><td> - <p><code><a href="mean_degparms.html">mean_degparms()</a></code> </p> - </td> - <td><p>Calculate mean degradation parameters for an mmkin row object</p></td> - </tr><tr><td> - <p><code><a href="create_deg_func.html">create_deg_func()</a></code> </p> - </td> - <td><p>Create degradation functions for known analytical solutions</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="analytical-solutions">Analytical solutions <a href="#analytical-solutions" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Parent only model solutions</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="SFO.solution.html">SFO.solution()</a></code> </p> - </td> - <td><p>Single First-Order kinetics</p></td> - </tr><tr><td> - <p><code><a href="FOMC.solution.html">FOMC.solution()</a></code> </p> - </td> - <td><p>First-Order Multi-Compartment kinetics</p></td> - </tr><tr><td> - <p><code><a href="DFOP.solution.html">DFOP.solution()</a></code> </p> - </td> - <td><p>Double First-Order in Parallel kinetics</p></td> - </tr><tr><td> - <p><code><a href="SFORB.solution.html">SFORB.solution()</a></code> </p> - </td> - <td><p>Single First-Order Reversible Binding kinetics</p></td> - </tr><tr><td> - <p><code><a href="HS.solution.html">HS.solution()</a></code> </p> - </td> - <td><p>Hockey-Stick kinetics</p></td> - </tr><tr><td> - <p><code><a href="IORE.solution.html">IORE.solution()</a></code> </p> - </td> - <td><p>Indeterminate order rate equation kinetics</p></td> - </tr><tr><td> - <p><code><a href="logistic.solution.html">logistic.solution()</a></code> </p> - </td> - <td><p>Logistic kinetics</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="generate-synthetic-datasets">Generate synthetic datasets <a href="#generate-synthetic-datasets" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="add_err.html">add_err()</a></code> </p> - </td> - <td><p>Add normally distributed errors to simulated kinetic degradation data</p></td> - </tr><tr><td> - <p><code><a href="sigma_twocomp.html">sigma_twocomp()</a></code> </p> - </td> - <td><p>Two-component error model</p></td> - </tr></tbody><tbody><tr><th colspan="2"> - <h2 id="deprecated-functions">Deprecated functions <a href="#deprecated-functions" class="anchor" aria-hidden="true"></a></h2> - <p class="section-desc"></p><p>Functions that have been superseded</p> - </th> - </tr></tbody><tbody><tr><td> - <p><code><a href="mkinplot.html">mkinplot()</a></code> </p> - </td> - <td><p>Plot the observed data and the fitted model of an mkinfit object</p></td> - </tr></tbody></table></div> - - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/intervals.nlmixr.mmkin.html b/docs/dev/reference/intervals.nlmixr.mmkin.html deleted file mode 100644 index 14f11c0c..00000000 --- a/docs/dev/reference/intervals.nlmixr.mmkin.html +++ /dev/null @@ -1,132 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit 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intervals for parameters in nlmixr.mmkin objects</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for nlmixr.mmkin</span> -<span class="fu"><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></span><span class="op">(</span><span class="va">object</span>, level <span class="op">=</span> <span class="fl">0.95</span>, backtransform <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The fitted saem.mmkin object</p></dd> -<dt>level</dt> -<dd><p>The confidence level.</p></dd> -<dt>backtransform</dt> -<dd><p>Should we backtransform the parameters where a one to -one correlation between transformed and backtransformed parameters exists?</p></dd> -<dt>...</dt> -<dd><p>For compatibility with the generic method</p></dd> -</dl></div> - <div id="value"> - <h2>Value</h2> - <p>An object with 'intervals.saem.mmkin' and 'intervals.lme' in the -class attribute</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/intervals.saem.mmkin.html b/docs/dev/reference/intervals.saem.mmkin.html deleted file mode 100644 index a566ee8d..00000000 --- a/docs/dev/reference/intervals.saem.mmkin.html +++ /dev/null @@ -1,169 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; 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aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Confidence intervals for parameters in saem.mmkin objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/intervals.R" class="external-link"><code>R/intervals.R</code></a></small> - <div class="hidden name"><code>intervals.saem.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Confidence intervals for parameters in saem.mmkin objects</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></span><span class="op">(</span><span class="va">object</span>, level <span class="op">=</span> <span class="fl">0.95</span>, backtransform <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The fitted saem.mmkin object</p></dd> - - -<dt>level</dt> -<dd><p>The confidence level. Must be the default of 0.95 as this is what -is available in the saemix object</p></dd> - - -<dt>backtransform</dt> -<dd><p>In case the model was fitted with mkin transformations, -should we backtransform the parameters where a one to one correlation -between transformed and backtransformed parameters exists?</p></dd> - - -<dt>...</dt> -<dd><p>For compatibility with the generic method</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An object with 'intervals.saem.mmkin' and 'intervals.lme' in the -class attribute</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/llhist.html b/docs/dev/reference/llhist.html deleted file mode 100644 index 2b5afa25..00000000 --- a/docs/dev/reference/llhist.html +++ /dev/null @@ -1,168 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Plot the distribution of log likelihoods from multistart objects — llhist • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Plot the distribution of log likelihoods from multistart objects — llhist"><meta property="og:description" content="Produces a histogram of log-likelihoods. In addition, the likelihood of the -original fit is shown as a red vertical line."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot the distribution of log likelihoods from multistart objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/llhist.R" class="external-link"><code>R/llhist.R</code></a></small> - <div class="hidden name"><code>llhist.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Produces a histogram of log-likelihoods. In addition, the likelihood of the -original fit is shown as a red vertical line.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">llhist</span><span class="op">(</span><span class="va">object</span>, breaks <span class="op">=</span> <span class="st">"Sturges"</span>, lpos <span class="op">=</span> <span class="st">"topleft"</span>, main <span class="op">=</span> <span class="st">""</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The <a href="multistart.html">multistart</a> object</p></dd> - - -<dt>breaks</dt> -<dd><p>Passed to <a href="https://rdrr.io/r/graphics/hist.html" class="external-link">hist</a></p></dd> - - -<dt>lpos</dt> -<dd><p>Positioning of the legend.</p></dd> - - -<dt>main</dt> -<dd><p>Title of the plot</p></dd> - - -<dt>...</dt> -<dd><p>Passed to <a href="https://rdrr.io/r/graphics/hist.html" class="external-link">hist</a></p></dd> - -</dl></div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="multistart.html">multistart</a></p></div> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/loftest-1.png b/docs/dev/reference/loftest-1.png Binary files differdeleted file mode 100644 index 750a2acf..00000000 --- a/docs/dev/reference/loftest-1.png +++ /dev/null diff --git a/docs/dev/reference/loftest-2.png b/docs/dev/reference/loftest-2.png Binary files differdeleted file mode 100644 index d12c26e7..00000000 --- a/docs/dev/reference/loftest-2.png +++ /dev/null diff --git a/docs/dev/reference/loftest-3.png b/docs/dev/reference/loftest-3.png Binary files differdeleted file mode 100644 index 9f45c74d..00000000 --- a/docs/dev/reference/loftest-3.png +++ /dev/null diff --git a/docs/dev/reference/loftest-4.png b/docs/dev/reference/loftest-4.png Binary files differdeleted file mode 100644 index 3beb9d1a..00000000 --- a/docs/dev/reference/loftest-4.png +++ /dev/null diff --git a/docs/dev/reference/loftest-5.png b/docs/dev/reference/loftest-5.png Binary files differdeleted file mode 100644 index 1a3aaeea..00000000 --- a/docs/dev/reference/loftest-5.png +++ /dev/null diff --git a/docs/dev/reference/loftest.html b/docs/dev/reference/loftest.html deleted file mode 100644 index 871dfc88..00000000 --- a/docs/dev/reference/loftest.html +++ /dev/null @@ -1,342 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Lack-of-fit test for models fitted to data with replicates — loftest • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Lack-of-fit test for models fitted to data with replicates — loftest"><meta property="og:description" content="This is a generic function with a method currently only defined for mkinfit -objects. It fits an anova model to the data contained in the object and -compares the likelihoods using the likelihood ratio test -lrtest.default from the lmtest package."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Lack-of-fit test for models fitted to data with replicates</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/loftest.R" class="external-link"><code>R/loftest.R</code></a></small> - <div class="hidden name"><code>loftest.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This is a generic function with a method currently only defined for mkinfit -objects. It fits an anova model to the data contained in the object and -compares the likelihoods using the likelihood ratio test -<code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest.default</a></code> from the lmtest package.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">loftest</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu">loftest</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A model object with a defined loftest method</p></dd> - - -<dt>...</dt> -<dd><p>Not used</p></dd> - -</dl></div> - <div id="details"> - <h2>Details</h2> - <p>The anova model is interpreted as the simplest form of an mkinfit model, -assuming only a constant variance about the means, but not enforcing any -structure of the means, so we have one model parameter for every mean -of replicate samples.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>lrtest</p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">test_data</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">sfo_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_fit</span><span class="op">)</span> <span class="co"># We see a clear pattern in the residuals</span></span></span> -<span class="r-plt img"><img src="loftest-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_fit</span><span class="op">)</span> <span class="co"># We have a clear lack of fit</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 10 -40.710 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -7 46.487 7.027e-08 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># We try a different model (the one that was used to generate the data)</span></span></span> -<span class="r-in"><span><span class="va">dfop_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">dfop_fit</span><span class="op">)</span> <span class="co"># We don't see systematic deviations, but heteroscedastic residuals</span></span></span> -<span class="r-plt img"><img src="loftest-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># therefore we should consider adapting the error model, although we have</span></span></span> -<span class="r-in"><span><span class="fu">loftest</span><span class="op">(</span><span class="va">dfop_fit</span><span class="op">)</span> <span class="co"># no lack of fit</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> -<span class="r-out co"><span class="r-pr">#></span> 1 10 -40.710 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 5 -42.453 -5 3.485 0.6257</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># This is the anova model used internally for the comparison</span></span></span> -<span class="r-in"><span><span class="va">test_data_anova</span> <span class="op"><-</span> <span class="va">test_data</span></span></span> -<span class="r-in"><span><span class="va">test_data_anova</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova</span><span class="op">$</span><span class="va">time</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">anova_fit</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/lm.html" class="external-link">lm</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="va">time</span>, data <span class="op">=</span> <span class="va">test_data_anova</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">anova_fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Call:</span> -<span class="r-out co"><span class="r-pr">#></span> lm(formula = value ~ time, data = test_data_anova)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Residuals:</span> -<span class="r-out co"><span class="r-pr">#></span> Min 1Q Median 3Q Max </span> -<span class="r-out co"><span class="r-pr">#></span> -6.1000 -0.5625 0.0000 0.5625 6.1000 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Coefficients:</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error t value Pr(>|t|) </span> -<span class="r-out co"><span class="r-pr">#></span> (Intercept) 103.150 2.323 44.409 7.44e-12 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time1 -19.950 3.285 -6.073 0.000185 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time3 -50.800 3.285 -15.465 8.65e-08 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time7 -68.500 3.285 -20.854 6.28e-09 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time14 -79.750 3.285 -24.278 1.63e-09 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time28 -86.000 3.285 -26.181 8.35e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time60 -94.900 3.285 -28.891 3.48e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time90 -98.500 3.285 -29.986 2.49e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time120 -100.450 3.285 -30.580 2.09e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Residual standard error: 3.285 on 9 degrees of freedom</span> -<span class="r-out co"><span class="r-pr">#></span> Multiple R-squared: 0.9953, Adjusted R-squared: 0.9912 </span> -<span class="r-out co"><span class="r-pr">#></span> F-statistic: 240.5 on 8 and 9 DF, p-value: 1.417e-09</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></span><span class="op">(</span><span class="va">anova_fit</span><span class="op">)</span> <span class="co"># We get the same likelihood and degrees of freedom</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 'log Lik.' -40.71015 (df=10)</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="va">test_data_2</span> <span class="op"><-</span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span></span> -<span class="r-in"><span><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">sfo_lin_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_lin_fit</span><span class="op">)</span> <span class="co"># not a good model, we try parallel formation</span></span></span> -<span class="r-plt img"><img src="loftest-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_lin_fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_SFO_lin with error model const and fixed parameter(s) M1_0, M2_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 7 -171.927 -21 156.64 < 2.2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="va">m_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">sfo_par_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_par</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">sfo_par_fit</span><span class="op">)</span> <span class="co"># much better for metabolites</span></span></span> -<span class="r-plt img"><img src="loftest-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">loftest</span><span class="op">(</span><span class="va">sfo_par_fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_SFO_par with error model const and fixed parameter(s) M1_0, M2_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 7 -156.331 -21 125.45 < 2.2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">dfop_par_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>, <span class="va">test_data_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">dfop_par_fit</span><span class="op">)</span> <span class="co"># No visual lack of fit</span></span></span> -<span class="r-plt img"><img src="loftest-5.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">loftest</span><span class="op">(</span><span class="va">dfop_par_fit</span><span class="op">)</span> <span class="co"># no lack of fit found by the test</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: ANOVA with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: m_synth_DFOP_par with error model const and fixed parameter(s) M1_0, M2_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> -<span class="r-out co"><span class="r-pr">#></span> 1 28 -93.606 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 9 -102.763 -19 18.313 0.5016</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># The anova model used for comparison in the case of transformation products</span></span></span> -<span class="r-in"><span><span class="va">test_data_anova_2</span> <span class="op"><-</span> <span class="va">dfop_par_fit</span><span class="op">$</span><span class="va">data</span></span></span> -<span class="r-in"><span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">variable</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">variable</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/factor.html" class="external-link">as.factor</a></span><span class="op">(</span><span class="va">test_data_anova_2</span><span class="op">$</span><span class="va">time</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">anova_fit_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/lm.html" class="external-link">lm</a></span><span class="op">(</span><span class="va">observed</span> <span class="op">~</span> <span class="va">time</span><span class="op">:</span><span class="va">variable</span> <span class="op">-</span> <span class="fl">1</span>, data <span class="op">=</span> <span class="va">test_data_anova_2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">anova_fit_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Call:</span> -<span class="r-out co"><span class="r-pr">#></span> lm(formula = observed ~ time:variable - 1, data = test_data_anova_2)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Residuals:</span> -<span class="r-out co"><span class="r-pr">#></span> Min 1Q Median 3Q Max </span> -<span class="r-out co"><span class="r-pr">#></span> -6.1000 -0.5875 0.0000 0.5875 6.1000 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Coefficients: (2 not defined because of singularities)</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error t value Pr(>|t|) </span> -<span class="r-out co"><span class="r-pr">#></span> time0:variableparent 103.150 1.573 65.562 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time1:variableparent 83.200 1.573 52.882 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time3:variableparent 52.350 1.573 33.274 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time7:variableparent 34.650 1.573 22.024 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time14:variableparent 23.400 1.573 14.873 6.35e-14 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time28:variableparent 17.150 1.573 10.901 5.47e-11 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time60:variableparent 8.250 1.573 5.244 1.99e-05 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time90:variableparent 4.650 1.573 2.956 0.006717 ** </span> -<span class="r-out co"><span class="r-pr">#></span> time120:variableparent 2.700 1.573 1.716 0.098507 . </span> -<span class="r-out co"><span class="r-pr">#></span> time0:variableM1 NA NA NA NA </span> -<span class="r-out co"><span class="r-pr">#></span> time1:variableM1 11.850 1.573 7.532 6.93e-08 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time3:variableM1 22.700 1.573 14.428 1.26e-13 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time7:variableM1 33.050 1.573 21.007 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time14:variableM1 31.250 1.573 19.863 < 2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time28:variableM1 18.900 1.573 12.013 7.02e-12 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time60:variableM1 7.550 1.573 4.799 6.28e-05 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time90:variableM1 3.850 1.573 2.447 0.021772 * </span> -<span class="r-out co"><span class="r-pr">#></span> time120:variableM1 2.050 1.573 1.303 0.204454 </span> -<span class="r-out co"><span class="r-pr">#></span> time0:variableM2 NA NA NA NA </span> -<span class="r-out co"><span class="r-pr">#></span> time1:variableM2 6.700 1.573 4.259 0.000254 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time3:variableM2 16.750 1.573 10.646 8.93e-11 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time7:variableM2 25.800 1.573 16.399 6.89e-15 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time14:variableM2 28.600 1.573 18.178 6.35e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time28:variableM2 25.400 1.573 16.144 9.85e-15 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time60:variableM2 21.600 1.573 13.729 3.81e-13 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time90:variableM2 17.800 1.573 11.314 2.51e-11 ***</span> -<span class="r-out co"><span class="r-pr">#></span> time120:variableM2 14.100 1.573 8.962 2.79e-09 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Residual standard error: 2.225 on 25 degrees of freedom</span> -<span class="r-out co"><span class="r-pr">#></span> Multiple R-squared: 0.9979, Adjusted R-squared: 0.9957 </span> -<span class="r-out co"><span class="r-pr">#></span> F-statistic: 469.2 on 25 and 25 DF, p-value: < 2.2e-16</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/logLik.mkinfit.html b/docs/dev/reference/logLik.mkinfit.html deleted file mode 100644 index e51a52eb..00000000 --- a/docs/dev/reference/logLik.mkinfit.html +++ /dev/null @@ -1,204 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Calculated the log-likelihood of a fitted mkinfit object — logLik.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" 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class="external-link">dnorm</a></code>, i.e. assuming normal distribution, and with the means -predicted by the degradation model, and the standard deviations predicted by -the error model.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>...</dt> -<dd><p>For compatibility with the generic method</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An object of class <code><a href="https://rdrr.io/r/stats/logLik.html" class="external-link">logLik</a></code> with the number of estimated -parameters (degradation model parameters plus variance model parameters) -as attribute.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>The total number of estimated parameters returned with the value of the -likelihood is calculated as the sum of fitted degradation model parameters -and the fitted error model parameters.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Compare the AIC of columns of <code><a href="mmkin.html">mmkin</a></code> objects using -<code><a href="AIC.mmkin.html">AIC.mmkin</a></code>.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="va">d_t</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nw</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">sfo_sfo</span>, <span class="va">d_t</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span> <span class="co"># no weighting (weights are unity)</span></span></span> -<span class="r-in"><span> <span class="va">f_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_nw</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_nw</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nw</span>, <span class="va">f_obs</span>, <span class="va">f_tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> f_nw 5 204.4486</span> -<span class="r-out co"><span class="r-pr">#></span> f_obs 6 205.8727</span> -<span class="r-out co"><span class="r-pr">#></span> f_tc 6 141.9656</span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs 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class="external-link">logLik</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span>, method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"is"</span>, <span class="st">"lin"</span>, <span class="st">"gq"</span><span class="op">)</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The fitted <a href="saem.html">saem.mmkin</a> object</p></dd> - - -<dt>...</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/saemix/man/logLik.html" class="external-link">saemix::logLik.SaemixObject</a></p></dd> - - -<dt>method</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/saemix/man/logLik.html" class="external-link">saemix::logLik.SaemixObject</a></p></dd> - -</dl></div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav 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class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Logistic kinetics</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parent_solutions.R" class="external-link"><code>R/parent_solutions.R</code></a></small> - <div class="hidden name"><code>logistic.solution.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing exponential decline from a defined starting value, with -an increasing rate constant, supposedly caused by microbial growth</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">logistic.solution</span><span class="op">(</span><span class="va">t</span>, <span class="va">parent_0</span>, <span class="va">kmax</span>, <span class="va">k0</span>, <span class="va">r</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>t</dt> -<dd><p>Time.</p></dd> - - -<dt>parent_0</dt> -<dd><p>Starting value for the response variable at time zero.</p></dd> - - -<dt>kmax</dt> -<dd><p>Maximum rate constant.</p></dd> - - -<dt>k0</dt> -<dd><p>Minimum rate constant effective at time zero.</p></dd> - - -<dt>r</dt> -<dd><p>Growth rate of the increase in the rate constant.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The value of the response variable at time <code>t</code>.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>The solution of the logistic model reduces to the -<code><a href="SFO.solution.html">SFO.solution</a></code> if <code>k0</code> is equal to <code>kmax</code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a> -FOCUS (2014) “Generic guidance for Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -Version 1.1, 18 December 2014 -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p>Other parent solutions: -<code><a href="DFOP.solution.html">DFOP.solution</a>()</code>, -<code><a href="FOMC.solution.html">FOMC.solution</a>()</code>, -<code><a href="HS.solution.html">HS.solution</a>()</code>, -<code><a href="IORE.solution.html">IORE.solution</a>()</code>, -<code><a href="SFO.solution.html">SFO.solution</a>()</code>, -<code><a href="SFORB.solution.html">SFORB.solution</a>()</code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># Reproduce the plot on page 57 of FOCUS (2014)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">100</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> xlab <span class="op">=</span> <span class="st">"Time"</span>, ylab <span class="op">=</span> <span class="st">"Residue"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.4</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">2</span>, col <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.0001</span>, <span class="fl">0.8</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">3</span>, col <span class="op">=</span> <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.001</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">4</span>, col <span class="op">=</span> <span class="fl">4</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu">logistic.solution</span><span class="op">(</span><span class="va">x</span>, <span class="fl">100</span>, <span class="fl">0.08</span>, <span class="fl">0.08</span>, <span class="fl">0.2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> from <span class="op">=</span> <span class="fl">0</span>, to <span class="op">=</span> <span class="fl">100</span>, add <span class="op">=</span> <span class="cn">TRUE</span>, lty <span class="op">=</span> <span class="fl">5</span>, col <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></span><span class="op">(</span><span class="st">"topright"</span>, inset <span class="op">=</span> <span class="fl">0.05</span>,</span></span> -<span class="r-in"><span> legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"k0 = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.0001</span>, <span class="fl">0.001</span>, <span class="fl">0.08</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="st">", r = "</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.2</span>, <span class="fl">0.4</span>, <span class="fl">0.8</span>, <span class="fl">0.2</span>, <span class="fl">0.2</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> lty <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, col <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="logistic.solution-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># Fit with synthetic data</span></span></span> -<span class="r-in"><span> <span class="va">logistic</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"logistic"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">parms_logistic</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>kmax <span class="op">=</span> <span class="fl">0.08</span>, k0 <span class="op">=</span> <span class="fl">0.0001</span>, r <span class="op">=</span> <span class="fl">0.2</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">d_logistic</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">logistic</span>,</span></span> -<span class="r-in"><span> <span class="va">parms_logistic</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">d_2_1</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_logistic</span>,</span></span> -<span class="r-in"><span> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="sigma_twocomp.html">sigma_twocomp</a></span><span class="op">(</span><span class="va">x</span>, <span class="fl">0.5</span>, <span class="fl">0.07</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> n <span class="op">=</span> <span class="fl">1</span>, reps <span class="op">=</span> <span class="fl">2</span>, digits <span class="op">=</span> <span class="fl">5</span>, LOD <span class="op">=</span> <span class="fl">0.1</span>, seed <span class="op">=</span> <span class="fl">123456</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">m</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"logistic"</span>, <span class="va">d_2_1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="logistic.solution-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.057896e+02 1.9023449590 55.610120 3.768360e-16 1.016451e+02</span> -<span class="r-out co"><span class="r-pr">#></span> kmax 6.398190e-02 0.0143201029 4.467978 3.841828e-04 3.929235e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k0 1.612775e-04 0.0005866813 0.274898 3.940351e-01 5.846688e-08</span> -<span class="r-out co"><span class="r-pr">#></span> r 2.263946e-01 0.1718110662 1.317695 1.061043e-01 4.335843e-02</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.332935e+00 0.9145907310 5.830952 4.036926e-05 3.340213e+00</span> -<span class="r-out co"><span class="r-pr">#></span> Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 109.9341588</span> -<span class="r-out co"><span class="r-pr">#></span> kmax 0.1041853</span> -<span class="r-out co"><span class="r-pr">#></span> k0 0.4448749</span> -<span class="r-out co"><span class="r-pr">#></span> r 1.1821120</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 7.3256566</span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">m</span><span class="op">)</span><span class="op">$</span><span class="va">distimes</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_k0 DT50_kmax</span> -<span class="r-out co"><span class="r-pr">#></span> parent 36.86533 62.41511 4297.853 10.83349</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/lrtest.mkinfit.html b/docs/dev/reference/lrtest.mkinfit.html deleted file mode 100644 index d59590c0..00000000 --- a/docs/dev/reference/lrtest.mkinfit.html +++ /dev/null @@ -1,233 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do 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If two fitted -mkinfit objects are given as arguments, it is checked if they have been -fitted to the same data. It is the responsibility of the user to make sure -that the models are nested, i.e. one of them has less degrees of freedom -and can be expressed by fixing the parameters of the other."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Likelihood ratio test for mkinfit models</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/lrtest.mkinfit.R" class="external-link"><code>R/lrtest.mkinfit.R</code></a></small> - <div class="hidden name"><code>lrtest.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Compare two mkinfit models based on their likelihood. If two fitted -mkinfit objects are given as arguments, it is checked if they have been -fitted to the same data. It is the responsibility of the user to make sure -that the models are nested, i.e. one of them has less degrees of freedom -and can be expressed by fixing the parameters of the other.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">object</span>, object_2 <span class="op">=</span> <span class="cn">NULL</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <code><a href="mkinfit.html">mkinfit</a></code> object, or an <code><a href="mmkin.html">mmkin</a></code> column -object containing two fits to the same data.</p></dd> - - -<dt>object_2</dt> -<dd><p>Optionally, another mkinfit object fitted to the same data.</p></dd> - - -<dt>...</dt> -<dd><p>Argument to <code><a href="mkinfit.html">mkinfit</a></code>, passed to -<code><a href="update.mkinfit.html">update.mkinfit</a></code> for creating the alternative fitted object.</p></dd> - -</dl></div> - <div id="details"> - <h2>Details</h2> - <p>Alternatively, an argument to mkinfit can be given which is then passed -to <code><a href="update.mkinfit.html">update.mkinfit</a></code> to obtain the alternative model.</p> -<p>The comparison is then made by the <code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest.default</a></code> -method from the lmtest package. The model with the higher number of fitted -parameters (alternative hypothesis) is listed first, then the model with the -lower number of fitted parameters (null hypothesis).</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">test_data</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">sfo_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dfop_fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">test_data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="va">sfo_fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -2 43.002 4.594e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">sfo_fit</span>, <span class="va">dfop_fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 3 -63.954 -2 43.002 4.594e-10 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The following two examples are commented out as they fail during</span></span></span> -<span class="r-in"><span><span class="co"># generation of the static help pages by pkgdown</span></span></span> -<span class="r-in"><span><span class="co">#lrtest(dfop_fit, error_model = "tc")</span></span></span> -<span class="r-in"><span><span class="co">#lrtest(dfop_fit, fixed_parms = c(k2 = 0))</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># However, this equivalent syntax also works for static help pages</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">dfop_fit</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model tc</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 6 -34.587 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 5 -42.453 -1 15.731 7.302e-05 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">dfop_fit</span>, <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">dfop_fit</span>, fixed_parms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: DFOP with error model const</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: DFOP with error model const and fixed parameter(s) k2</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 5 -42.453 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 4 -57.340 -1 29.776 4.851e-08 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/max_twa_parent.html b/docs/dev/reference/max_twa_parent.html deleted file mode 100644 index 507a0758..00000000 --- a/docs/dev/reference/max_twa_parent.html +++ /dev/null @@ -1,239 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do 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</div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Function to calculate maximum time weighted average concentrations from -kinetic models fitted with mkinfit</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/max_twa_parent.R" class="external-link"><code>R/max_twa_parent.R</code></a></small> - <div class="hidden name"><code>max_twa_parent.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function calculates maximum moving window time weighted average -concentrations (TWAs) for kinetic models fitted with <code><a href="mkinfit.html">mkinfit</a></code>. -Currently, only calculations for the parent are implemented for the SFO, -FOMC, DFOP and HS models, using the analytical formulas given in the PEC -soil section of the FOCUS guidance.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">max_twa_parent</span><span class="op">(</span><span class="va">fit</span>, <span class="va">windows</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">max_twa_sfo</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k</span>, <span class="va">t</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">max_twa_fomc</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">alpha</span>, <span class="va">beta</span>, <span class="va">t</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">max_twa_dfop</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">t</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">max_twa_hs</span><span class="op">(</span>M0 <span class="op">=</span> <span class="fl">1</span>, <span class="va">k1</span>, <span class="va">k2</span>, <span class="va">tb</span>, <span class="va">t</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>fit</dt> -<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>windows</dt> -<dd><p>The width of the time windows for which the TWAs should be -calculated.</p></dd> - - -<dt>M0</dt> -<dd><p>The initial concentration for which the maximum time weighted -average over the decline curve should be calculated. The default is to use -a value of 1, which means that a relative maximum time weighted average -factor (f_twa) is calculated.</p></dd> - - -<dt>k</dt> -<dd><p>The rate constant in the case of SFO kinetics.</p></dd> - - -<dt>t</dt> -<dd><p>The width of the time window.</p></dd> - - -<dt>alpha</dt> -<dd><p>Parameter of the FOMC model.</p></dd> - - -<dt>beta</dt> -<dd><p>Parameter of the FOMC model.</p></dd> - - -<dt>k1</dt> -<dd><p>The first rate constant of the DFOP or the HS kinetics.</p></dd> - - -<dt>k2</dt> -<dd><p>The second rate constant of the DFOP or the HS kinetics.</p></dd> - - -<dt>g</dt> -<dd><p>Parameter of the DFOP model.</p></dd> - - -<dt>tb</dt> -<dd><p>Parameter of the HS model.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>For <code>max_twa_parent</code>, a numeric vector, named using the -<code>windows</code> argument. For the other functions, a numeric vector of -length one (also known as 'a number').</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu">max_twa_parent</span><span class="op">(</span><span class="va">fit</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">7</span>, <span class="fl">21</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> 7 21 </span> -<span class="r-out co"><span class="r-pr">#></span> 34.71343 18.22124 </span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mccall81_245T-1.png b/docs/dev/reference/mccall81_245T-1.png Binary files differdeleted file mode 100644 index 5e4ea6ef..00000000 --- a/docs/dev/reference/mccall81_245T-1.png +++ /dev/null diff --git a/docs/dev/reference/mccall81_245T.html b/docs/dev/reference/mccall81_245T.html deleted file mode 100644 index c0e9cb37..00000000 --- a/docs/dev/reference/mccall81_245T.html +++ /dev/null @@ -1,247 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Datasets on aerobic soil metabolism of 2,4,5-T in six soils — mccall81_245T • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Datasets on aerobic soil metabolism of 2,4,5-T in six soils — mccall81_245T"><meta property="og:description" content="Time course of 2,4,5-trichlorophenoxyacetic acid, and the corresponding - 2,4,5-trichlorophenol and 2,4,5-trichloroanisole as recovered in diethylether - extracts."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - 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<span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Datasets on aerobic soil metabolism of 2,4,5-T in six soils</h1> - - <div class="hidden name"><code>mccall81_245T.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Time course of 2,4,5-trichlorophenoxyacetic acid, and the corresponding - 2,4,5-trichlorophenol and 2,4,5-trichloroanisole as recovered in diethylether - extracts.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">mccall81_245T</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A dataframe containing the following variables.</p><dl><dt><code>name</code></dt> -<dd><p>the name of the compound observed. Note that T245 is used as - an acronym for 2,4,5-T. T245 is a legitimate object name - in R, which is necessary for specifying models using - <code><a href="mkinmod.html">mkinmod</a></code>.</p></dd> - - <dt><code>time</code></dt> -<dd><p>a numeric vector containing sampling times in days after - treatment</p></dd> - - <dt><code>value</code></dt> -<dd><p>a numeric vector containing concentrations in percent of applied radioactivity</p></dd> - - <dt><code>soil</code></dt> -<dd><p>a factor containing the name of the soil</p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>McCall P, Vrona SA, Kelley SS (1981) Fate of uniformly carbon-14 ring labelled 2,4,5-Trichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid. J Agric Chem 29, 100-107 - <a href="https://doi.org/10.1021/jf00103a026" class="external-link">doi:10.1021/jf00103a026</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span> <span class="va">SFO_SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>T245 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"phenol"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> phenol <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"anisole"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> anisole <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit.1</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO_SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t)</span> -<span class="r-out co"><span class="r-pr">#></span> T245_0 1.038550e+02 2.1847074945 47.537272 4.472189e-18</span> -<span class="r-out co"><span class="r-pr">#></span> k_T245 4.337042e-02 0.0018983965 22.845818 2.276911e-13</span> -<span class="r-out co"><span class="r-pr">#></span> k_phenol 4.050581e-01 0.2986993563 1.356073 9.756989e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_anisole 6.678742e-03 0.0008021439 8.326114 2.623177e-07</span> -<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 6.227599e-01 0.3985340558 1.562627 6.949413e-02</span> -<span class="r-out co"><span class="r-pr">#></span> f_phenol_to_anisole 1.000000e+00 0.6718439825 1.488441 7.867789e-02</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.514628e+00 0.4907558883 5.123989 6.233157e-05</span> -<span class="r-out co"><span class="r-pr">#></span> Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> T245_0 99.246061385 1.084640e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_T245 0.039631621 4.746194e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_phenol 0.218013879 7.525762e-01</span> -<span class="r-out co"><span class="r-pr">#></span> k_anisole 0.005370739 8.305299e-03</span> -<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 0.547559081 6.924813e-01</span> -<span class="r-out co"><span class="r-pr">#></span> f_phenol_to_anisole 0.000000000 1.000000e+00</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.706607296 3.322649e+00</span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> T245_phenol T245_sink phenol_anisole phenol_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> T245 15.982025 53.09114</span> -<span class="r-out co"><span class="r-pr">#></span> phenol 1.711229 5.68458</span> -<span class="r-out co"><span class="r-pr">#></span> anisole 103.784093 344.76329</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="co"># formation fraction from phenol to anisol is practically 1. As we cannot</span></span></span> -<span class="r-in"><span> <span class="co"># fix formation fractions when using the ilr transformation, we can turn of</span></span></span> -<span class="r-in"><span> <span class="co"># the sink in the model generation</span></span></span> -<span class="r-in"><span> <span class="va">SFO_SFO_SFO_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>T245 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"phenol"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> phenol <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"anisole"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> anisole <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="va">fit.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO_SFO_2</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> -<span class="r-out co"><span class="r-pr">#></span> T245_0 1.038550e+02 2.1623653066 48.028439 4.993108e-19 99.271020284</span> -<span class="r-out co"><span class="r-pr">#></span> k_T245 4.337042e-02 0.0018343666 23.643268 3.573556e-14 0.039650976</span> -<span class="r-out co"><span class="r-pr">#></span> k_phenol 4.050582e-01 0.1177237473 3.440752 1.679254e-03 0.218746587</span> -<span class="r-out co"><span class="r-pr">#></span> k_anisole 6.678742e-03 0.0006829745 9.778903 1.872894e-08 0.005377083</span> -<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 6.227599e-01 0.0342197875 18.198824 2.039411e-12 0.547975637</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.514628e+00 0.3790944250 6.633250 2.875782e-06 1.710983655</span> -<span class="r-out co"><span class="r-pr">#></span> Upper</span> -<span class="r-out co"><span class="r-pr">#></span> T245_0 108.43904074</span> -<span class="r-out co"><span class="r-pr">#></span> k_T245 0.04743877</span> -<span class="r-out co"><span class="r-pr">#></span> k_phenol 0.75005585</span> -<span class="r-out co"><span class="r-pr">#></span> k_anisole 0.00829550</span> -<span class="r-out co"><span class="r-pr">#></span> f_T245_to_phenol 0.69212308</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.31827222</span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.1</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> T245_phenol T245_sink phenol_anisole phenol_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 6.227599e-01 3.772401e-01 1.000000e+00 3.773626e-10 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> T245 15.982025 53.09114</span> -<span class="r-out co"><span class="r-pr">#></span> phenol 1.711229 5.68458</span> -<span class="r-out co"><span class="r-pr">#></span> anisole 103.784093 344.76329</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mccall81_245T-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git 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class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Calculate mean degradation parameters for an mmkin row object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mean_degparms.R" class="external-link"><code>R/mean_degparms.R</code></a></small> - <div class="hidden name"><code>mean_degparms.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Calculate mean degradation parameters for an mmkin row object</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mean_degparms</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> random <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span> -<span> default_log_parms <span class="op">=</span> <span class="cn">NA</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An mmkin row object containing several fits of the same model to different datasets</p></dd> - - -<dt>random</dt> -<dd><p>Should a list with fixed and random effects be returned?</p></dd> - - -<dt>test_log_parms</dt> -<dd><p>If TRUE, log parameters are only considered in -the mean calculations if their untransformed counterparts (most likely -rate constants) pass the t-test for significant difference from zero.</p></dd> - - -<dt>conf.level</dt> -<dd><p>Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.</p></dd> - - -<dt>default_log_parms</dt> -<dd><p>If set to a numeric value, this is used -as a default value for the tested log parameters that failed the -t-test.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>If random is FALSE (default), a named vector containing mean values -of the fitted degradation model parameters. If random is TRUE, a list with -fixed and random effects, in the format required by the start argument of -nlme for the case of a single grouping variable ds.</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mhmkin-1.png b/docs/dev/reference/mhmkin-1.png Binary files differdeleted file mode 100644 index 1c99aead..00000000 --- a/docs/dev/reference/mhmkin-1.png +++ /dev/null diff --git a/docs/dev/reference/mhmkin-2.png b/docs/dev/reference/mhmkin-2.png Binary files differdeleted file mode 100644 index ea04ebfd..00000000 --- a/docs/dev/reference/mhmkin-2.png +++ /dev/null diff --git a/docs/dev/reference/mhmkin.html b/docs/dev/reference/mhmkin.html deleted file mode 100644 index b41c11df..00000000 --- a/docs/dev/reference/mhmkin.html +++ /dev/null @@ -1,336 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models — mhmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models — mhmkin"><meta property="og:description" content="The name of the methods expresses that (multiple) hierarchichal -(also known as multilevel) multicompartment kinetic models are -fitted. 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<span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Fit nonlinear mixed-effects models built from one or more kinetic -degradation models and one or more error models</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mhmkin.R" class="external-link"><code>R/mhmkin.R</code></a></small> - <div class="hidden name"><code>mhmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The name of the methods expresses that (<strong>m</strong>ultiple) <strong>h</strong>ierarchichal -(also known as multilevel) <strong>m</strong>ulticompartment <strong>kin</strong>etic models are -fitted. Our kinetic models are nonlinear, so we can use various nonlinear -mixed-effects model fitting functions.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre><code>mhmkin(objects, ...) - -# S3 method for mmkin -mhmkin(objects, ...) - -# S3 method for list -mhmkin( - objects, - backend = "saemix", - algorithm = "saem", - no_random_effect = NULL, - ..., - cores = if (Sys.info()["sysname"] == "Windows") 1 else parallel::detectCores(), - cluster = NULL -) - -# S3 method for mhmkin -[(x, i, j, ..., drop = FALSE) - -# S3 method for mhmkin -print(x, ...)</code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>objects</dt> -<dd><p>A list of <a href="mmkin.html">mmkin</a> objects containing fits of the same -degradation models to the same data, but using different error models. -Alternatively, a single <a href="mmkin.html">mmkin</a> object containing fits of several -degradation models to the same data</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments that will be passed to the nonlinear mixed-effects -model fitting function.</p></dd> - - -<dt>backend</dt> -<dd><p>The backend to be used for fitting. Currently, only saemix is -supported</p></dd> - - -<dt>algorithm</dt> -<dd><p>The algorithm to be used for fitting (currently not used)</p></dd> - - -<dt>no_random_effect</dt> -<dd><p>Default is NULL and will be passed to <a href="saem.html">saem</a>. If a -character vector is supplied, it will be passed to all calls to <a href="saem.html">saem</a>, -which will exclude random effects for all matching parameters. Alternatively, -a list of character vectors or an object of class <a href="illparms.html">illparms.mhmkin</a> can be -specified. They have to have the same dimensions that the return object of -the current call will have, i.e. the number of rows must match the number -of degradation models in the mmkin object(s), and the number of columns must -match the number of error models used in the mmkin object(s).</p></dd> - - -<dt>cores</dt> -<dd><p>The number of cores to be used for multicore processing. This -is only used when the <code>cluster</code> argument is <code>NULL</code>. On Windows -machines, cores > 1 is not supported, you need to use the <code>cluster</code> -argument to use multiple logical processors. Per default, all cores detected -by <code><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">parallel::detectCores()</a></code> are used, except on Windows where the default -is 1.</p></dd> - - -<dt>cluster</dt> -<dd><p>A cluster as returned by makeCluster to be used for -parallel execution.</p></dd> - - -<dt>x</dt> -<dd><p>An mhmkin object.</p></dd> - - -<dt>i</dt> -<dd><p>Row index selecting the fits for specific models</p></dd> - - -<dt>j</dt> -<dd><p>Column index selecting the fits to specific datasets</p></dd> - - -<dt>drop</dt> -<dd><p>If FALSE, the method always returns an mhmkin object, otherwise -either a list of fit objects or a single fit object.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A two-dimensional <a href="https://rdrr.io/r/base/array.html" class="external-link">array</a> of fit objects and/or try-errors that can -be indexed using the degradation model names for the first index (row index) -and the error model names for the second index (column index), with class -attribute 'mhmkin'.</p> - - -<p>An object inheriting from <code>mhmkin</code>.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code>[.mhmkin</code> for subsetting mhmkin objects</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># We start with separate evaluations of all the first six datasets with two</span></span></span> -<span class="r-in"><span><span class="co"># degradation models and two error models</span></span></span> -<span class="r-in"><span><span class="va">f_sep_const</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>, <span class="va">ds_fomc</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">6</span><span class="op">]</span>, cores <span class="op">=</span> <span class="fl">2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_sep_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_sep_const</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># The mhmkin function sets up hierarchical degradation models aka</span></span></span> -<span class="r-in"><span><span class="co"># nonlinear mixed-effects models for all four combinations, specifying</span></span></span> -<span class="r-in"><span><span class="co"># uncorrelated random effects for all degradation parameters</span></span></span> -<span class="r-in"><span><span class="va">f_saem_1</span> <span class="op"><-</span> <span class="fu">mhmkin</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">f_sep_const</span>, <span class="va">f_sep_tc</span><span class="op">)</span>, cores <span class="op">=</span> <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="status.html">status</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> error</span> -<span class="r-out co"><span class="r-pr">#></span> degradation const tc</span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: Fit terminated successfully</span> -<span class="r-in"><span><span class="co"># The 'illparms' function shows that in all hierarchical fits, at least</span></span></span> -<span class="r-in"><span><span class="co"># one random effect is ill-defined (the confidence interval for the</span></span></span> -<span class="r-in"><span><span class="co"># random effect expressed as standard deviation includes zero)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> error</span> -<span class="r-out co"><span class="r-pr">#></span> degradation const tc </span> -<span class="r-out co"><span class="r-pr">#></span> SFO sd(parent_0) sd(parent_0) </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC sd(log_beta) sd(parent_0), sd(log_beta)</span> -<span class="r-in"><span><span class="co"># Therefore we repeat the fits, excluding the ill-defined random effects</span></span></span> -<span class="r-in"><span><span class="va">f_saem_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_1</span>, no_random_effect <span class="op">=</span> <span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="status.html">status</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> error</span> -<span class="r-out co"><span class="r-pr">#></span> degradation const tc</span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: Fit terminated successfully</span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> error</span> -<span class="r-out co"><span class="r-pr">#></span> degradation const tc</span> -<span class="r-out co"><span class="r-pr">#></span> SFO </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC </span> -<span class="r-in"><span><span class="co"># Model comparisons show that FOMC with two-component error is preferable,</span></span></span> -<span class="r-in"><span><span class="co"># and confirms our reduction of the default parameter model</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_1</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 95 observations of 1 variable(s) grouped in 6 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> SFO const 5 574.40 573.35 -282.20</span> -<span class="r-out co"><span class="r-pr">#></span> SFO tc 6 543.72 542.47 -265.86</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC const 7 489.67 488.22 -237.84</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC tc 8 406.11 404.44 -195.05</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 95 observations of 1 variable(s) grouped in 6 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> SFO const 4 572.22 571.39 -282.11</span> -<span class="r-out co"><span class="r-pr">#></span> SFO tc 5 541.63 540.59 -265.81</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC const 6 487.38 486.13 -237.69</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC tc 6 402.12 400.88 -195.06</span> -<span class="r-in"><span><span class="co"># The convergence plot for the selected model looks fine</span></span></span> -<span class="r-in"><span><span class="fu">saemix</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mhmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># The plot of predictions versus data shows that we have a pretty data-rich</span></span></span> -<span class="r-in"><span><span class="co"># situation with homogeneous distribution of residuals, because we used the</span></span></span> -<span class="r-in"><span><span class="co"># same degradation model, error model and parameter distribution model that</span></span></span> -<span class="r-in"><span><span class="co"># was used in the data generation.</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_2</span><span class="op">[[</span><span class="st">"FOMC"</span>, <span class="st">"tc"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mhmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># We can specify the same parameter model reductions manually</span></span></span> -<span class="r-in"><span><span class="va">no_ranef</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"parent_0"</span>, <span class="st">"log_beta"</span>, <span class="st">"parent_0"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"parent_0"</span>, <span class="st">"log_beta"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/dim.html" class="external-link">dim</a></span><span class="op">(</span><span class="va">no_ranef</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">2</span>, <span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_2m</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_1</span>, no_random_effect <span class="op">=</span> <span class="va">no_ranef</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_2m</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 95 observations of 1 variable(s) grouped in 6 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> SFO const 4 572.22 571.39 -282.11</span> -<span class="r-out co"><span class="r-pr">#></span> SFO tc 5 541.63 540.59 -265.81</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC const 6 487.38 486.13 -237.69</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC tc 6 402.12 400.88 -195.06</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mixed-1.png b/docs/dev/reference/mixed-1.png Binary files differdeleted file mode 100644 index b053d9c9..00000000 --- a/docs/dev/reference/mixed-1.png +++ /dev/null diff --git a/docs/dev/reference/mixed.html b/docs/dev/reference/mixed.html deleted file mode 100644 index 1709944a..00000000 --- a/docs/dev/reference/mixed.html +++ 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with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a 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href="https://github.com/jranke/mkin/blob/HEAD/R/mixed.mmkin.R" class="external-link"><code>R/mixed.mmkin.R</code></a></small> - <div class="hidden name"><code>mixed.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Create a mixed effects model from an mmkin row object</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">mixed</span><span class="op">(</span><span class="va">object</span>, method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"none"</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mixed.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <a href="mmkin.html">mmkin</a> row object</p></dd> - - -<dt>...</dt> -<dd><p>Currently not used</p></dd> - - -<dt>method</dt> -<dd><p>The method to be used</p></dd> - - -<dt>x</dt> -<dd><p>A mixed.mmkin object to print</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An object of class 'mixed.mmkin' which has the observed data in a -single dataframe which is convenient for plotting</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">n_biphasic</span> <span class="op"><-</span> <span class="fl">8</span></span></span> -<span class="r-in"><span><span class="va">err_1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>const <span class="op">=</span> <span class="fl">1</span>, prop <span class="op">=</span> <span class="fl">0.07</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">DFOP_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">log_sd</span> <span class="op"><-</span> <span class="fl">0.3</span></span></span> -<span class="r-in"><span><span class="va">syn_biphasic_parms</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">as.matrix</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> k1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.05</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> k2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.01</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> g <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> f_parent_to_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fl">0</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> k_m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="va">n_biphasic</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.002</span><span class="op">)</span>, <span class="va">log_sd</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">ds_biphasic_mean</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="va">n_biphasic</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">DFOP_SFO</span>, <span class="va">syn_biphasic_parms</span><span class="op">[</span><span class="va">i</span>, <span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="op">}</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456L</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ds_biphasic</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_biphasic_mean</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span></span> -<span class="r-in"><span> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="va">err_1</span><span class="op">$</span><span class="va">const</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="va">err_1</span><span class="op">$</span><span class="va">prop</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> n <span class="op">=</span> <span class="fl">1</span>, secondary <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">DFOP_SFO</span><span class="op">)</span>, <span class="va">ds_biphasic</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_mixed</span> <span class="op"><-</span> <span class="fu">mixed</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic model fitted by nonlinear regression to each dataset</span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> -<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_m1 * m1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 271 observations of 2 variable(s) grouped in 8 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model 1 2 3 4 5 6 7 8 </span> -<span class="r-out co"><span class="r-pr">#></span> DFOP-SFO OK OK OK OK OK OK OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Mean fitted parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 </span> -<span class="r-out co"><span class="r-pr">#></span> 100.674757 -8.761916 -0.004347 -3.348812 -3.986853 </span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> -<span class="r-out co"><span class="r-pr">#></span> -0.087392 </span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_mixed</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mixed-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkin_long_to_wide.html b/docs/dev/reference/mkin_long_to_wide.html deleted file mode 100644 index 990506b5..00000000 --- a/docs/dev/reference/mkin_long_to_wide.html +++ /dev/null @@ -1,201 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Convert a dataframe from long to wide format — mkin_long_to_wide • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" 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columns."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span 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href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Convert a dataframe from long to wide format</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkin_long_to_wide.R" class="external-link"><code>R/mkin_long_to_wide.R</code></a></small> - <div class="hidden name"><code>mkin_long_to_wide.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function takes a dataframe in the long form, i.e. with a row for each -observed value, and converts it into a dataframe with one independent -variable and several dependent variables as columns.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkin_long_to_wide</span><span class="op">(</span><span class="va">long_data</span>, time <span class="op">=</span> <span class="st">"time"</span>, outtime <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>long_data</dt> -<dd><p>The dataframe must contain one variable called "time" with -the time values specified by the <code>time</code> argument, one column called -"name" with the grouping of the observed values, and finally one column of -observed values called "value".</p></dd> - - -<dt>time</dt> -<dd><p>The name of the time variable in the long input data.</p></dd> - - -<dt>outtime</dt> -<dd><p>The name of the time variable in the wide output data.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Dataframe in wide format.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu">mkin_long_to_wide</span><span class="op">(</span><span class="va">FOCUS_2006_D</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time parent m1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 99.46 0.00</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 102.04 0.00</span> -<span class="r-out co"><span class="r-pr">#></span> 3 1 93.50 4.84</span> -<span class="r-out co"><span class="r-pr">#></span> 4 1 92.50 5.64</span> -<span class="r-out co"><span class="r-pr">#></span> 5 3 63.23 12.91</span> -<span class="r-out co"><span class="r-pr">#></span> 6 3 68.99 12.96</span> -<span class="r-out co"><span class="r-pr">#></span> 7 7 52.32 22.97</span> -<span class="r-out co"><span class="r-pr">#></span> 8 7 55.13 24.47</span> -<span class="r-out co"><span class="r-pr">#></span> 9 14 27.27 41.69</span> -<span class="r-out co"><span class="r-pr">#></span> 10 14 26.64 33.21</span> -<span class="r-out co"><span class="r-pr">#></span> 11 21 11.50 44.37</span> -<span class="r-out co"><span class="r-pr">#></span> 12 21 11.64 46.44</span> -<span class="r-out co"><span class="r-pr">#></span> 13 35 2.85 41.22</span> -<span class="r-out co"><span class="r-pr">#></span> 14 35 2.91 37.95</span> -<span class="r-out co"><span class="r-pr">#></span> 15 50 0.69 41.19</span> -<span class="r-out co"><span class="r-pr">#></span> 16 50 0.63 40.01</span> -<span class="r-out co"><span class="r-pr">#></span> 17 75 0.05 40.09</span> -<span class="r-out co"><span class="r-pr">#></span> 18 75 0.06 33.85</span> -<span class="r-out co"><span class="r-pr">#></span> 19 100 NA 31.04</span> -<span class="r-out co"><span class="r-pr">#></span> 20 100 NA 33.13</span> -<span class="r-out co"><span class="r-pr">#></span> 21 120 NA 25.15</span> -<span class="r-out co"><span class="r-pr">#></span> 22 120 NA 33.31</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkin_wide_to_long.html b/docs/dev/reference/mkin_wide_to_long.html deleted file mode 100644 index a324d3b8..00000000 --- a/docs/dev/reference/mkin_wide_to_long.html +++ /dev/null @@ -1,181 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Convert a dataframe with observations over time into long format — mkin_wide_to_long • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script 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navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Convert a dataframe with observations over time into long format</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkin_wide_to_long.R" class="external-link"><code>R/mkin_wide_to_long.R</code></a></small> - <div class="hidden name"><code>mkin_wide_to_long.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function simply takes a dataframe with one independent variable and -several dependent variable and converts it into the long form as required by -<code><a href="mkinfit.html">mkinfit</a></code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkin_wide_to_long</span><span class="op">(</span><span class="va">wide_data</span>, time <span class="op">=</span> <span class="st">"t"</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>wide_data</dt> -<dd><p>The dataframe must contain one variable with the time -values specified by the <code>time</code> argument and usually more than one -column of observed values.</p></dd> - - -<dt>time</dt> -<dd><p>The name of the time variable.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Dataframe in long format as needed for <code><a href="mkinfit.html">mkinfit</a></code>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">wide</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>t <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1</span>,<span class="fl">2</span>,<span class="fl">3</span><span class="op">)</span>, x <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1</span>,<span class="fl">4</span>,<span class="fl">7</span><span class="op">)</span>, y <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>,<span class="fl">4</span>,<span class="fl">5</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">mkin_wide_to_long</span><span class="op">(</span><span class="va">wide</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> name time value</span> -<span class="r-out co"><span class="r-pr">#></span> 1 x 1 1</span> -<span class="r-out co"><span class="r-pr">#></span> 2 x 2 4</span> -<span class="r-out co"><span class="r-pr">#></span> 3 x 3 7</span> -<span class="r-out co"><span class="r-pr">#></span> 4 y 1 3</span> -<span class="r-out co"><span class="r-pr">#></span> 5 y 2 4</span> -<span class="r-out co"><span class="r-pr">#></span> 6 y 3 5</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinds.html b/docs/dev/reference/mkinds.html deleted file mode 100644 index 6219766e..00000000 --- a/docs/dev/reference/mkinds.html +++ /dev/null @@ -1,262 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>A dataset class for mkin — mkinds • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script 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For example, -mkinfit does not take mkinds datasets as argument, but works with dataframes -such as the on contained in the data field of mkinds objects. Some datasets -provided by this package come as mkinds objects nevertheless."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>A dataset class for mkin</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinds.R" class="external-link"><code>R/mkinds.R</code></a></small> - <div class="hidden name"><code>mkinds.Rd</code></div> - </div> - - <div class="ref-description"> - <p>At the moment this dataset class is hardly used in mkin. For example, -mkinfit does not take mkinds datasets as argument, but works with dataframes -such as the on contained in the data field of mkinds objects. Some datasets -provided by this package come as mkinds objects nevertheless.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinds</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An mkinds object.</p></dd> - - -<dt>data</dt> -<dd><p>Should the data be printed?</p></dd> - - -<dt>...</dt> -<dd><p>Not used.</p></dd> - -</dl></div> - <div id="public-fields"> - <h2>Public fields</h2> - <p></p><div class="r6-fields"><dl><dt><code>title</code></dt> -<dd><p>A full title for the dataset</p></dd> - - -<dt><code>sampling_times</code></dt> -<dd><p>The sampling times</p></dd> - - -<dt><code>time_unit</code></dt> -<dd><p>The time unit</p></dd> - - -<dt><code>observed</code></dt> -<dd><p>Names of the observed variables</p></dd> - - -<dt><code>unit</code></dt> -<dd><p>The unit of the observations</p></dd> - - -<dt><code>replicates</code></dt> -<dd><p>The maximum number of replicates per sampling time</p></dd> - - -<dt><code>data</code></dt> -<dd><p>A data frame with at least the columns name, time -and value in order to be compatible with mkinfit</p></dd> - - -</dl><p></p></div> - </div> - <div id="methods"> - <h2>Methods</h2> - -<div class="section"> -<h3 id="public-methods">Public methods<a class="anchor" aria-label="anchor" href="#public-methods"></a></h3> - -<ul><li><p><a href="#method-mkinds-new"><code>mkinds$new()</code></a></p></li> -<li><p><a href="#method-mkinds-clone"><code>mkinds$clone()</code></a></p></li> -</ul></div><p></p><hr><a id="method-mkinds-new"></a><div class="section"> -<h3 id="method-new-">Method <code>new()</code><a class="anchor" aria-label="anchor" href="#method-new-"></a></h3> -<p>Create a new mkinds object</p><div class="section"> -<h4 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a></h4> -<p></p><div class="r"><div class="sourceCode"><pre><code><span><span class="va"><a href="../reference/mkinds.html">mkinds</a></span><span class="op">$</span><span class="fu">new</span><span class="op">(</span>title <span class="op">=</span> <span class="st">""</span>, <span class="va">data</span>, time_unit <span class="op">=</span> <span class="cn">NA</span>, unit <span class="op">=</span> <span class="cn">NA</span><span class="op">)</span></span></code></pre></div><p></p></div> -</div> - -<div class="section"> -<h4 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h4> -<p></p><div class="arguments"><dl><dt><code>title</code></dt> -<dd><p>The dataset title</p></dd> - - -<dt><code>data</code></dt> -<dd><p>The data</p></dd> - - -<dt><code>time_unit</code></dt> -<dd><p>The time unit</p></dd> - - -<dt><code>unit</code></dt> -<dd><p>The unit of the observations</p></dd> - - -</dl><p></p></div> -</div> - -</div><p></p><hr><a id="method-mkinds-clone"></a><div class="section"> -<h3 id="method-clone-">Method <code>clone()</code><a class="anchor" aria-label="anchor" href="#method-clone-"></a></h3> -<p>The objects of this class are cloneable with this method.</p><div class="section"> -<h4 id="usage-1">Usage<a class="anchor" aria-label="anchor" href="#usage-1"></a></h4> -<p></p><div class="r"><div class="sourceCode"><pre><code><span><span class="va">mkinds</span><span class="op">$</span><span class="fu">clone</span><span class="op">(</span>deep <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div><p></p></div> -</div> - -<div class="section"> -<h4 id="arguments-1">Arguments<a class="anchor" aria-label="anchor" href="#arguments-1"></a></h4> -<p></p><div class="arguments"><dl><dt><code>deep</code></dt> -<dd><p>Whether to make a deep clone.</p></dd> - - -</dl><p></p></div> -</div> - -</div> - - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">mds</span> <span class="op"><-</span> <span class="va">mkinds</span><span class="op">$</span><span class="fu">new</span><span class="op">(</span><span class="st">"FOCUS A"</span>, <span class="va">FOCUS_2006_A</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mds</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: FOCUS A </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 62, 90, 118 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 1 replicates</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkindsg.html b/docs/dev/reference/mkindsg.html deleted file mode 100644 index 6e221a23..00000000 --- a/docs/dev/reference/mkindsg.html +++ /dev/null @@ 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title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>A class for dataset groups for mkin</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinds.R" class="external-link"><code>R/mkinds.R</code></a></small> - <div class="hidden name"><code>mkindsg.Rd</code></div> - </div> - - <div class="ref-description"> - <p>A container for working with datasets that share at least one compound, -so that combined evaluations are desirable.</p> -<p>Time normalisation factors are initialised with a value of 1 for each -dataset if no data are supplied.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkindsg</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, verbose <span class="op">=</span> <span class="va">data</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An mkindsg object.</p></dd> - - -<dt>data</dt> -<dd><p>Should the mkinds objects be printed with their data?</p></dd> - - -<dt>verbose</dt> -<dd><p>Should the mkinds objects be printed?</p></dd> - - -<dt>...</dt> -<dd><p>Not used.</p></dd> - -</dl></div> - <div id="public-fields"> - <h2>Public fields</h2> - <p></p><div class="r6-fields"><dl><dt><code>title</code></dt> -<dd><p>A title for the dataset group</p></dd> - - -<dt><code>ds</code></dt> -<dd><p>A list of mkinds objects</p></dd> - - -<dt><code>observed_n</code></dt> -<dd><p>Occurrence counts of compounds in datasets</p></dd> - - -<dt><code>f_time_norm</code></dt> -<dd><p>Time normalisation factors</p></dd> - - -<dt><code>meta</code></dt> -<dd><p>A data frame with a row for each dataset, -containing additional information in the form -of categorical data (factors) or numerical data -(e.g. temperature, moisture, -or covariates like soil pH).</p></dd> - - -</dl><p></p></div> - </div> - <div id="methods"> - <h2>Methods</h2> - -<div class="section"> -<h3 id="public-methods">Public methods<a class="anchor" aria-label="anchor" href="#public-methods"></a></h3> - -<ul><li><p><a href="#method-mkindsg-new"><code>mkindsg$new()</code></a></p></li> -<li><p><a href="#method-mkindsg-clone"><code>mkindsg$clone()</code></a></p></li> -</ul></div><p></p><hr><a id="method-mkindsg-new"></a><div class="section"> -<h3 id="method-new-">Method <code>new()</code><a class="anchor" aria-label="anchor" href="#method-new-"></a></h3> -<p>Create a new mkindsg object</p><div class="section"> -<h4 id="usage">Usage<a class="anchor" aria-label="anchor" href="#usage"></a></h4> -<p></p><div class="r"><div class="sourceCode"><pre><code><span><span class="va"><a href="../reference/mkindsg.html">mkindsg</a></span><span class="op">$</span><span class="fu">new</span><span class="op">(</span>title <span class="op">=</span> <span class="st">""</span>, <span class="va">ds</span>, f_time_norm <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span><span class="op">)</span>, <span class="va">meta</span><span class="op">)</span></span></code></pre></div><p></p></div> -</div> - -<div class="section"> -<h4 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h4> -<p></p><div class="arguments"><dl><dt><code>title</code></dt> -<dd><p>The title</p></dd> - - -<dt><code>ds</code></dt> -<dd><p>A list of mkinds objects</p></dd> - - -<dt><code>f_time_norm</code></dt> -<dd><p>Time normalisation factors</p></dd> - - -<dt><code>meta</code></dt> -<dd><p>The meta data</p></dd> - - -</dl><p></p></div> -</div> - -</div><p></p><hr><a id="method-mkindsg-clone"></a><div class="section"> -<h3 id="method-clone-">Method <code>clone()</code><a class="anchor" aria-label="anchor" href="#method-clone-"></a></h3> -<p>The objects of this class are cloneable with this method.</p><div class="section"> -<h4 id="usage-1">Usage<a class="anchor" aria-label="anchor" href="#usage-1"></a></h4> -<p></p><div class="r"><div class="sourceCode"><pre><code><span><span class="va">mkindsg</span><span class="op">$</span><span class="fu">clone</span><span class="op">(</span>deep <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div><p></p></div> -</div> - -<div class="section"> -<h4 id="arguments-1">Arguments<a class="anchor" aria-label="anchor" href="#arguments-1"></a></h4> -<p></p><div class="arguments"><dl><dt><code>deep</code></dt> -<dd><p>Whether to make a deep clone.</p></dd> - - -</dl><p></p></div> -</div> - -</div> - - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">mdsg</span> <span class="op"><-</span> <span class="va">mkindsg</span><span class="op">$</span><span class="fu">new</span><span class="op">(</span><span class="st">"Experimental X"</span>, <span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> -<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> -<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> -<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> -<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> -<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> -<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Datasets $ds:</span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 6 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 7 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 60, 90, 120, 180 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 8 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 9 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 10 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 8, 14, 21, 41, 63, 91, 120 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">mdsg</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkindsg> holding 5 mkinds objects</span> -<span class="r-out co"><span class="r-pr">#></span> Title $title: Experimental X </span> -<span class="r-out co"><span class="r-pr">#></span> Occurrence of observed compounds $observed_n:</span> -<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Datasets $ds:</span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 6 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 3, 6, 10, 20, 34, 55, 90, 112, 132 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 97.2 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 96.4 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 71.1 4.3</span> -<span class="r-out co"><span class="r-pr">#></span> 4 3 69.2 4.6</span> -<span class="r-out co"><span class="r-pr">#></span> 5 6 58.1 7.0</span> -<span class="r-out co"><span class="r-pr">#></span> 6 6 56.6 7.2</span> -<span class="r-out co"><span class="r-pr">#></span> 7 10 44.4 8.2</span> -<span class="r-out co"><span class="r-pr">#></span> 8 10 43.4 8.0</span> -<span class="r-out co"><span class="r-pr">#></span> 9 20 33.3 11.0</span> -<span class="r-out co"><span class="r-pr">#></span> 10 20 29.2 13.7</span> -<span class="r-out co"><span class="r-pr">#></span> 11 34 17.6 11.5</span> -<span class="r-out co"><span class="r-pr">#></span> 12 34 18.0 12.7</span> -<span class="r-out co"><span class="r-pr">#></span> 13 55 10.5 14.9</span> -<span class="r-out co"><span class="r-pr">#></span> 14 55 9.3 14.5</span> -<span class="r-out co"><span class="r-pr">#></span> 15 90 4.5 12.1</span> -<span class="r-out co"><span class="r-pr">#></span> 16 90 4.7 12.3</span> -<span class="r-out co"><span class="r-pr">#></span> 17 112 3.0 9.9</span> -<span class="r-out co"><span class="r-pr">#></span> 18 112 3.4 10.2</span> -<span class="r-out co"><span class="r-pr">#></span> 19 132 2.3 8.8</span> -<span class="r-out co"><span class="r-pr">#></span> 20 132 2.7 7.8</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 7 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 3, 7, 14, 30, 60, 90, 120, 180 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 93.6 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 92.3 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 87.0 3.9</span> -<span class="r-out co"><span class="r-pr">#></span> 4 3 82.2 3.1</span> -<span class="r-out co"><span class="r-pr">#></span> 5 7 74.0 6.9</span> -<span class="r-out co"><span class="r-pr">#></span> 6 7 73.9 6.6</span> -<span class="r-out co"><span class="r-pr">#></span> 7 14 64.2 10.4</span> -<span class="r-out co"><span class="r-pr">#></span> 8 14 69.5 8.3</span> -<span class="r-out co"><span class="r-pr">#></span> 9 30 54.0 14.4</span> -<span class="r-out co"><span class="r-pr">#></span> 10 30 54.6 13.7</span> -<span class="r-out co"><span class="r-pr">#></span> 11 60 41.1 22.1</span> -<span class="r-out co"><span class="r-pr">#></span> 12 60 38.4 22.3</span> -<span class="r-out co"><span class="r-pr">#></span> 13 90 32.5 27.5</span> -<span class="r-out co"><span class="r-pr">#></span> 14 90 35.5 25.4</span> -<span class="r-out co"><span class="r-pr">#></span> 15 120 28.1 28.0</span> -<span class="r-out co"><span class="r-pr">#></span> 16 120 29.0 26.6</span> -<span class="r-out co"><span class="r-pr">#></span> 17 180 26.5 25.8</span> -<span class="r-out co"><span class="r-pr">#></span> 18 180 27.6 25.3</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 8 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 91.9 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 90.8 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 3 1 64.9 9.6</span> -<span class="r-out co"><span class="r-pr">#></span> 4 1 66.2 7.7</span> -<span class="r-out co"><span class="r-pr">#></span> 5 3 43.5 15.0</span> -<span class="r-out co"><span class="r-pr">#></span> 6 3 44.1 15.1</span> -<span class="r-out co"><span class="r-pr">#></span> 7 8 18.3 21.2</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 18.1 21.1</span> -<span class="r-out co"><span class="r-pr">#></span> 9 14 10.2 19.7</span> -<span class="r-out co"><span class="r-pr">#></span> 10 14 10.8 18.9</span> -<span class="r-out co"><span class="r-pr">#></span> 11 27 4.9 17.5</span> -<span class="r-out co"><span class="r-pr">#></span> 12 27 3.3 15.9</span> -<span class="r-out co"><span class="r-pr">#></span> 13 48 1.6 9.5</span> -<span class="r-out co"><span class="r-pr">#></span> 14 48 1.5 9.8</span> -<span class="r-out co"><span class="r-pr">#></span> 15 70 1.1 6.2</span> -<span class="r-out co"><span class="r-pr">#></span> 16 70 0.9 6.1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 9 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 1, 3, 8, 14, 27, 48, 70, 91, 120 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 99.8 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 98.3 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 3 1 77.1 4.2</span> -<span class="r-out co"><span class="r-pr">#></span> 4 1 77.2 3.9</span> -<span class="r-out co"><span class="r-pr">#></span> 5 3 59.0 7.4</span> -<span class="r-out co"><span class="r-pr">#></span> 6 3 58.1 7.9</span> -<span class="r-out co"><span class="r-pr">#></span> 7 8 27.4 14.5</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 29.2 13.7</span> -<span class="r-out co"><span class="r-pr">#></span> 9 14 19.1 14.2</span> -<span class="r-out co"><span class="r-pr">#></span> 10 14 29.6 12.2</span> -<span class="r-out co"><span class="r-pr">#></span> 11 27 10.1 13.7</span> -<span class="r-out co"><span class="r-pr">#></span> 12 27 18.2 13.2</span> -<span class="r-out co"><span class="r-pr">#></span> 13 48 4.5 13.6</span> -<span class="r-out co"><span class="r-pr">#></span> 14 48 9.1 15.4</span> -<span class="r-out co"><span class="r-pr">#></span> 15 70 2.3 10.4</span> -<span class="r-out co"><span class="r-pr">#></span> 16 70 2.9 11.6</span> -<span class="r-out co"><span class="r-pr">#></span> 17 91 2.0 10.0</span> -<span class="r-out co"><span class="r-pr">#></span> 18 91 1.8 9.5</span> -<span class="r-out co"><span class="r-pr">#></span> 19 120 2.0 9.1</span> -<span class="r-out co"><span class="r-pr">#></span> 20 120 2.2 9.0</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> <mkinds> with $title: Soil 10 </span> -<span class="r-out co"><span class="r-pr">#></span> Observed compounds $observed: parent, A1 </span> -<span class="r-out co"><span class="r-pr">#></span> Sampling times $sampling_times:</span> -<span class="r-out co"><span class="r-pr">#></span> 0, 8, 14, 21, 41, 63, 91, 120 </span> -<span class="r-out co"><span class="r-pr">#></span> With a maximum of 2 replicates</span> -<span class="r-out co"><span class="r-pr">#></span> Time unit: days </span> -<span class="r-out co"><span class="r-pr">#></span> Observation unit: \%AR </span> -<span class="r-out co"><span class="r-pr">#></span> time parent A1</span> -<span class="r-out co"><span class="r-pr">#></span> 1 0 96.1 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 2 0 94.3 NA</span> -<span class="r-out co"><span class="r-pr">#></span> 3 8 73.9 3.3</span> -<span class="r-out co"><span class="r-pr">#></span> 4 8 73.9 3.4</span> -<span class="r-out co"><span class="r-pr">#></span> 5 14 69.4 3.9</span> -<span class="r-out co"><span class="r-pr">#></span> 6 14 73.1 2.9</span> -<span class="r-out co"><span class="r-pr">#></span> 7 21 65.6 6.4</span> -<span class="r-out co"><span class="r-pr">#></span> 8 21 65.3 7.2</span> -<span class="r-out co"><span class="r-pr">#></span> 9 41 55.9 9.1</span> -<span class="r-out co"><span class="r-pr">#></span> 10 41 54.4 8.5</span> -<span class="r-out co"><span class="r-pr">#></span> 11 63 47.0 11.7</span> -<span class="r-out co"><span class="r-pr">#></span> 12 63 49.3 12.0</span> -<span class="r-out co"><span class="r-pr">#></span> 13 91 44.7 13.3</span> -<span class="r-out co"><span class="r-pr">#></span> 14 91 46.7 13.2</span> -<span class="r-out co"><span class="r-pr">#></span> 15 120 42.1 14.3</span> -<span class="r-out co"><span class="r-pr">#></span> 16 120 41.3 12.1</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinerrmin.html b/docs/dev/reference/mkinerrmin.html deleted file mode 100644 index 3a8b9610..00000000 --- a/docs/dev/reference/mkinerrmin.html +++ /dev/null @@ -1,210 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, 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property="og:title" content="Calculate the minimum error to assume in order to pass the variance test — mkinerrmin"><meta property="og:description" content="This function finds the smallest relative error still resulting in passing -the chi-squared test as defined in the FOCUS kinetics report from 2006."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container 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smallest relative error still resulting in passing -the chi-squared test as defined in the FOCUS kinetics report from 2006.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit</span>, alpha <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>fit</dt> -<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>alpha</dt> -<dd><p>The confidence level chosen for the chi-squared test.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A dataframe with the following components:</p> -<dl><dt>err.min</dt> -<dd><p>The -relative error, expressed as a fraction.</p></dd> - <dt>n.optim</dt> -<dd><p>The number of -optimised parameters attributed to the data series.</p></dd> - <dt>df</dt> -<dd><p>The number of -remaining degrees of freedom for the chi2 error level calculations. Note -that mean values are used for the chi2 statistic and therefore every time -point with observed values in the series only counts one time.</p></dd> -</dl><p>The -dataframe has one row for the total dataset and one further row for each -observed state variable in the model.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>This function is used internally by <code><a href="summary.mkinfit.html">summary.mkinfit</a></code>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU -Registration” Report of the FOCUS Work Group on Degradation Kinetics, EC -Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">fit_FOCUS_D</span> <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit_FOCUS_D</span><span class="op">)</span>, <span class="fl">4</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 0.0640 4 15</span> -<span class="r-out co"><span class="r-pr">#></span> parent 0.0646 2 7</span> -<span class="r-out co"><span class="r-pr">#></span> m1 0.0469 2 8</span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit_FOCUS_E</span> <span class="op">=</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_E</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">round</a></span><span class="op">(</span><span class="fu">mkinerrmin</span><span class="op">(</span><span class="va">fit_FOCUS_E</span><span class="op">)</span>, <span class="fl">4</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 0.1544 4 13</span> -<span class="r-out co"><span class="r-pr">#></span> parent 0.1659 2 7</span> -<span class="r-out co"><span class="r-pr">#></span> m1 0.1095 2 6</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinerrplot-1.png b/docs/dev/reference/mkinerrplot-1.png Binary files differdeleted file mode 100644 index 078614fc..00000000 --- a/docs/dev/reference/mkinerrplot-1.png +++ /dev/null diff --git a/docs/dev/reference/mkinerrplot.html b/docs/dev/reference/mkinerrplot.html deleted file mode 100644 index bc9b828a..00000000 --- a/docs/dev/reference/mkinerrplot.html +++ /dev/null @@ -1,245 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Function to plot squared residuals and the error model for an mkin object — mkinerrplot • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Function to plot squared residuals and the error model for an mkin object — mkinerrplot"><meta property="og:description" content="This function plots the squared residuals for the specified subset of the -observed variables from an mkinfit object. In addition, one or more dashed -line(s) show the fitted error model. A combined plot of the fitted model -and this error model plot can be obtained with plot.mkinfit -using the argument show_errplot = TRUE."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Function to plot squared residuals and the error model for an mkin object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinerrplot.R" class="external-link"><code>R/mkinerrplot.R</code></a></small> - <div class="hidden name"><code>mkinerrplot.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function plots the squared residuals for the specified subset of the -observed variables from an mkinfit object. In addition, one or more dashed -line(s) show the fitted error model. A combined plot of the fitted model -and this error model plot can be obtained with <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> -using the argument <code>show_errplot = TRUE</code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinerrplot</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>,</span> -<span> xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">predicted</span><span class="op">)</span><span class="op">)</span>,</span> -<span> xlab <span class="op">=</span> <span class="st">"Predicted"</span>,</span> -<span> ylab <span class="op">=</span> <span class="st">"Squared residual"</span>,</span> -<span> maxy <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> legend <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"topright"</span>,</span> -<span> col_obs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> pch_obs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> frame <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> - - -<dt>obs_vars</dt> -<dd><p>A character vector of names of the observed variables for -which residuals should be plotted. Defaults to all observed variables in -the model</p></dd> - - -<dt>xlim</dt> -<dd><p>plot range in x direction.</p></dd> - - -<dt>xlab</dt> -<dd><p>Label for the x axis.</p></dd> - - -<dt>ylab</dt> -<dd><p>Label for the y axis.</p></dd> - - -<dt>maxy</dt> -<dd><p>Maximum value of the residuals. This is used for the scaling of -the y axis and defaults to "auto".</p></dd> - - -<dt>legend</dt> -<dd><p>Should a legend be plotted?</p></dd> - - -<dt>lpos</dt> -<dd><p>Where should the legend be placed? Default is "topright". Will -be passed on to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code>.</p></dd> - - -<dt>col_obs</dt> -<dd><p>Colors for the observed variables.</p></dd> - - -<dt>pch_obs</dt> -<dd><p>Symbols to be used for the observed variables.</p></dd> - - -<dt>frame</dt> -<dd><p>Should a frame be drawn around the plots?</p></dd> - - -<dt>...</dt> -<dd><p>further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code><a href="mkinplot.html">mkinplot</a></code>, for a way to plot the data and the fitted -lines of the mkinfit object.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">FOCUS_2006_D</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span><span class="fu">mkinerrplot</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mkinerrplot-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinfit-1.png b/docs/dev/reference/mkinfit-1.png Binary files differdeleted file mode 100644 index 578f64a5..00000000 --- a/docs/dev/reference/mkinfit-1.png +++ /dev/null diff --git a/docs/dev/reference/mkinfit.html b/docs/dev/reference/mkinfit.html deleted file mode 100644 index 237d903e..00000000 --- a/docs/dev/reference/mkinfit.html +++ /dev/null @@ -1,719 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Fit a kinetic model to data with one or more state variables — mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Fit a kinetic model to data with one or more state variables — mkinfit"><meta property="og:description" content="This function maximises the likelihood of the observed data using the Port -algorithm stats::nlminb(), and the specified initial or fixed -parameters and starting values. In each step of the optimisation, the -kinetic model is solved using the function mkinpredict(), except -if an analytical solution is implemented, in which case the model is solved -using the degradation function in the mkinmod object. The -parameters of the selected error model are fitted simultaneously with the -degradation model parameters, as both of them are arguments of the -likelihood function."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - 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<span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Fit a kinetic model to data with one or more state variables</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinfit.R" class="external-link"><code>R/mkinfit.R</code></a></small> - <div class="hidden name"><code>mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function maximises the likelihood of the observed data using the Port -algorithm <code><a href="https://rdrr.io/r/stats/nlminb.html" class="external-link">stats::nlminb()</a></code>, and the specified initial or fixed -parameters and starting values. In each step of the optimisation, the -kinetic model is solved using the function <code><a href="mkinpredict.html">mkinpredict()</a></code>, except -if an analytical solution is implemented, in which case the model is solved -using the degradation function in the <a href="mkinmod.html">mkinmod</a> object. The -parameters of the selected error model are fitted simultaneously with the -degradation model parameters, as both of them are arguments of the -likelihood function.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinfit</span><span class="op">(</span></span> -<span> <span class="va">mkinmod</span>,</span> -<span> <span class="va">observed</span>,</span> -<span> parms.ini <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> state.ini <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> err.ini <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> fixed_parms <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> fixed_initials <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">diffs</span><span class="op">)</span><span class="op">[</span><span class="op">-</span><span class="fl">1</span><span class="op">]</span>,</span> -<span> from_max_mean <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> solution_type <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"analytical"</span>, <span class="st">"eigen"</span>, <span class="st">"deSolve"</span><span class="op">)</span>,</span> -<span> method.ode <span class="op">=</span> <span class="st">"lsoda"</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>eval.max <span class="op">=</span> <span class="fl">300</span>, iter.max <span class="op">=</span> <span class="fl">200</span><span class="op">)</span>,</span> -<span> transform_rates <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> transform_fractions <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> atol <span class="op">=</span> <span class="fl">1e-08</span>,</span> -<span> rtol <span class="op">=</span> <span class="fl">1e-10</span>,</span> -<span> error_model <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"const"</span>, <span class="st">"obs"</span>, <span class="st">"tc"</span><span class="op">)</span>,</span> -<span> error_model_algorithm <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"auto"</span>, <span class="st">"d_3"</span>, <span class="st">"direct"</span>, <span class="st">"twostep"</span>, <span class="st">"threestep"</span>, <span class="st">"fourstep"</span>,</span> -<span> <span class="st">"IRLS"</span>, <span class="st">"OLS"</span><span class="op">)</span>,</span> -<span> reweight.tol <span class="op">=</span> <span class="fl">1e-08</span>,</span> -<span> reweight.max.iter <span class="op">=</span> <span class="fl">10</span>,</span> -<span> trace_parms <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> test_residuals <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>mkinmod</dt> -<dd><p>A list of class <a href="mkinmod.html">mkinmod</a>, containing the kinetic -model to be fitted to the data, or one of the shorthand names ("SFO", -"FOMC", "DFOP", "HS", "SFORB", "IORE"). If a shorthand name is given, a -parent only degradation model is generated for the variable with the -highest value in <code>observed</code>.</p></dd> - - -<dt>observed</dt> -<dd><p>A dataframe with the observed data. The first column called -"name" must contain the name of the observed variable for each data point. -The second column must contain the times of observation, named "time". -The third column must be named "value" and contain the observed values. -Zero values in the "value" column will be removed, with a warning, in -order to avoid problems with fitting the two-component error model. This -is not expected to be a problem, because in general, values of zero are -not observed in degradation data, because there is a lower limit of -detection.</p></dd> - - -<dt>parms.ini</dt> -<dd><p>A named vector of initial values for the parameters, -including parameters to be optimised and potentially also fixed parameters -as indicated by <code>fixed_parms</code>. If set to "auto", initial values for -rate constants are set to default values. Using parameter names that are -not in the model gives an error.</p> -<p>It is possible to only specify a subset of the parameters that the model -needs. You can use the parameter lists "bparms.ode" from a previously -fitted model, which contains the differential equation parameters from -this model. This works nicely if the models are nested. An example is -given below.</p></dd> - - -<dt>state.ini</dt> -<dd><p>A named vector of initial values for the state variables of -the model. In case the observed variables are represented by more than one -model variable, the names will differ from the names of the observed -variables (see <code>map</code> component of <a href="mkinmod.html">mkinmod</a>). The default -is to set the initial value of the first model variable to the mean of the -time zero values for the variable with the maximum observed value, and all -others to 0. If this variable has no time zero observations, its initial -value is set to 100.</p></dd> - - -<dt>err.ini</dt> -<dd><p>A named vector of initial values for the error model -parameters to be optimised. If set to "auto", initial values are set to -default values. Otherwise, inital values for all error model parameters -must be given.</p></dd> - - -<dt>fixed_parms</dt> -<dd><p>The names of parameters that should not be optimised but -rather kept at the values specified in <code>parms.ini</code>. Alternatively, -a named numeric vector of parameters to be fixed, regardless of the values -in parms.ini.</p></dd> - - -<dt>fixed_initials</dt> -<dd><p>The names of model variables for which the initial -state at time 0 should be excluded from the optimisation. Defaults to all -state variables except for the first one.</p></dd> - - -<dt>from_max_mean</dt> -<dd><p>If this is set to TRUE, and the model has only one -observed variable, then data before the time of the maximum observed value -(after averaging for each sampling time) are discarded, and this time is -subtracted from all remaining time values, so the time of the maximum -observed mean value is the new time zero.</p></dd> - - -<dt>solution_type</dt> -<dd><p>If set to "eigen", the solution of the system of -differential equations is based on the spectral decomposition of the -coefficient matrix in cases that this is possible. If set to "deSolve", a -numerical <a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">ode solver from package deSolve</a> is used. If -set to "analytical", an analytical solution of the model is used. This is -only implemented for relatively simple degradation models. The default is -"auto", which uses "analytical" if possible, otherwise "deSolve" if a -compiler is present, and "eigen" if no compiler is present and the model -can be expressed using eigenvalues and eigenvectors.</p></dd> - - -<dt>method.ode</dt> -<dd><p>The solution method passed via <code><a href="mkinpredict.html">mkinpredict()</a></code> -to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code> in case the solution type is "deSolve". The default -"lsoda" is performant, but sometimes fails to converge.</p></dd> - - -<dt>use_compiled</dt> -<dd><p>If set to <code>FALSE</code>, no compiled version of the -<a href="mkinmod.html">mkinmod</a> model is used in the calls to <code><a href="mkinpredict.html">mkinpredict()</a></code> even if a compiled -version is present.</p></dd> - - -<dt>control</dt> -<dd><p>A list of control arguments passed to <code><a href="https://rdrr.io/r/stats/nlminb.html" class="external-link">stats::nlminb()</a></code>.</p></dd> - - -<dt>transform_rates</dt> -<dd><p>Boolean specifying if kinetic rate constants should -be transformed in the model specification used in the fitting for better -compliance with the assumption of normal distribution of the estimator. If -TRUE, also alpha and beta parameters of the FOMC model are -log-transformed, as well as k1 and k2 rate constants for the DFOP and HS -models and the break point tb of the HS model. If FALSE, zero is used as -a lower bound for the rates in the optimisation.</p></dd> - - -<dt>transform_fractions</dt> -<dd><p>Boolean specifying if formation fractions -should be transformed in the model specification used in the fitting for -better compliance with the assumption of normal distribution of the -estimator. The default (TRUE) is to do transformations. If TRUE, -the g parameter of the DFOP model is also transformed. Transformations -are described in <a href="transform_odeparms.html">transform_odeparms</a>.</p></dd> - - -<dt>quiet</dt> -<dd><p>Suppress printing out the current value of the negative -log-likelihood after each improvement?</p></dd> - - -<dt>atol</dt> -<dd><p>Absolute error tolerance, passed to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>. Default -is 1e-8, which is lower than the default in the <code><a href="https://rdrr.io/pkg/deSolve/man/lsoda.html" class="external-link">deSolve::lsoda()</a></code> -function which is used per default.</p></dd> - - -<dt>rtol</dt> -<dd><p>Absolute error tolerance, passed to <code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>. Default -is 1e-10, much lower than in <code><a href="https://rdrr.io/pkg/deSolve/man/lsoda.html" class="external-link">deSolve::lsoda()</a></code>.</p></dd> - - -<dt>error_model</dt> -<dd><p>If the error model is "const", a constant standard -deviation is assumed.</p> -<p>If the error model is "obs", each observed variable is assumed to have its -own variance.</p> -<p>If the error model is "tc" (two-component error model), a two component -error model similar to the one described by Rocke and Lorenzato (1995) is -used for setting up the likelihood function. Note that this model -deviates from the model by Rocke and Lorenzato, as their model implies -that the errors follow a lognormal distribution for large values, not a -normal distribution as assumed by this method.</p></dd> - - -<dt>error_model_algorithm</dt> -<dd><p>If "auto", the selected algorithm depends on -the error model. If the error model is "const", unweighted nonlinear -least squares fitting ("OLS") is selected. If the error model is "obs", or -"tc", the "d_3" algorithm is selected.</p> -<p>The algorithm "d_3" will directly minimize the negative log-likelihood -and independently also use the three step algorithm described below. -The fit with the higher likelihood is returned.</p> -<p>The algorithm "direct" will directly minimize the negative log-likelihood.</p> -<p>The algorithm "twostep" will minimize the negative log-likelihood after an -initial unweighted least squares optimisation step.</p> -<p>The algorithm "threestep" starts with unweighted least squares, then -optimizes only the error model using the degradation model parameters -found, and then minimizes the negative log-likelihood with free -degradation and error model parameters.</p> -<p>The algorithm "fourstep" starts with unweighted least squares, then -optimizes only the error model using the degradation model parameters -found, then optimizes the degradation model again with fixed error model -parameters, and finally minimizes the negative log-likelihood with free -degradation and error model parameters.</p> -<p>The algorithm "IRLS" (Iteratively Reweighted Least Squares) starts with -unweighted least squares, and then iterates optimization of the error -model parameters and subsequent optimization of the degradation model -using those error model parameters, until the error model parameters -converge.</p></dd> - - -<dt>reweight.tol</dt> -<dd><p>Tolerance for the convergence criterion calculated from -the error model parameters in IRLS fits.</p></dd> - - -<dt>reweight.max.iter</dt> -<dd><p>Maximum number of iterations in IRLS fits.</p></dd> - - -<dt>trace_parms</dt> -<dd><p>Should a trace of the parameter values be listed?</p></dd> - - -<dt>test_residuals</dt> -<dd><p>Should the residuals be tested for normal distribution?</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments that will be passed on to -<code><a href="https://rdrr.io/pkg/deSolve/man/ode.html" class="external-link">deSolve::ode()</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A list with "mkinfit" in the class attribute.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>Per default, parameters in the kinetic models are internally transformed in -order to better satisfy the assumption of a normal distribution of their -estimators.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>When using the "IORE" submodel for metabolites, fitting with -"transform_rates = TRUE" (the default) often leads to failures of the -numerical ODE solver. In this situation it may help to switch off the -internal rate transformation.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Rocke DM and Lorenzato S (1995) A two-component model -for measurement error in analytical chemistry. <em>Technometrics</em> 37(2), 176-184.</p> -<p>Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical -Degradation Data. <em>Environments</em> 6(12) 124 -<a href="https://doi.org/10.3390/environments6120124" class="external-link">doi:10.3390/environments6120124</a> -.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="summary.mkinfit.html">summary.mkinfit</a>, <a href="plot.mkinfit.html">plot.mkinfit</a>, <a href="parms.html">parms</a> and <a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a>.</p> -<p>Comparisons of models fitted to the same data can be made using -<code><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></code> by virtue of the method <code><a href="logLik.mkinfit.html">logLik.mkinfit</a></code>.</p> -<p>Fitting of several models to several datasets in a single call to -<code><a href="mmkin.html">mmkin</a></code>.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Use shorthand notation for parent only degradation</span></span></span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:30:40 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:30:40 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted using 222 model solutions performed in 0.014 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 85.1 state</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 1.0 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> beta 10.0 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 85.100000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.000000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 2.302585 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 44.68652 45.47542 -18.34326</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 85.87000 1.8070 81.23000 90.5200</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.05192 0.1353 -0.29580 0.3996</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 0.65100 0.2287 0.06315 1.2390</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.85700 0.4378 0.73200 2.9830</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_alpha log_beta sigma</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 -1.565e-01 -3.142e-01 4.772e-08</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha -1.565e-01 1.000e+00 9.564e-01 1.005e-07</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta -3.142e-01 9.564e-01 1.000e+00 8.541e-08</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 4.772e-08 1.005e-07 8.541e-08 1.000e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> -<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> -<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 85.870 47.530 3.893e-08 81.2300 90.520</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 1.053 7.393 3.562e-04 0.7439 1.491</span> -<span class="r-out co"><span class="r-pr">#></span> beta 1.917 4.373 3.601e-03 1.0650 3.451</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.857 4.243 4.074e-03 0.7320 2.983</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 6.657 3 6</span> -<span class="r-out co"><span class="r-pr">#></span> parent 6.657 3 6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> -<span class="r-out co"><span class="r-pr">#></span> parent 1.785 15.15 4.56</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> -<span class="r-out co"><span class="r-pr">#></span> 0 parent 85.1 85.875 -0.7749</span> -<span class="r-out co"><span class="r-pr">#></span> 1 parent 57.9 55.191 2.7091</span> -<span class="r-out co"><span class="r-pr">#></span> 3 parent 29.9 31.845 -1.9452</span> -<span class="r-out co"><span class="r-pr">#></span> 7 parent 14.6 17.012 -2.4124</span> -<span class="r-out co"><span class="r-pr">#></span> 14 parent 9.7 9.241 0.4590</span> -<span class="r-out co"><span class="r-pr">#></span> 28 parent 6.6 4.754 1.8460</span> -<span class="r-out co"><span class="r-pr">#></span> 63 parent 4.0 2.102 1.8977</span> -<span class="r-out co"><span class="r-pr">#></span> 91 parent 3.9 1.441 2.4590</span> -<span class="r-out co"><span class="r-pr">#></span> 119 parent 0.6 1.092 -0.4919</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># One parent compound, one metabolite, both single first order.</span></span></span> -<span class="r-in"><span><span class="co"># We remove zero values from FOCUS dataset D in order to avoid warnings</span></span></span> -<span class="r-in"><span><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Use mkinsub for convenience in model formulation. Pathway to sink included per default.</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Fit the model quietly to the FOCUS example dataset D using defaults</span></span></span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mkinfit-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># As lower parent values appear to have lower variance, we try an alternative error model</span></span></span> -<span class="r-in"><span><span class="va">fit.tc</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># This avoids the warning, and the likelihood ratio test confirms it is preferable</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.tc</span>, <span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model const and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 6 -64.983 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 5 -97.224 -1 64.483 9.737e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="co"># We can also allow for different variances of parent and metabolite as error model</span></span></span> -<span class="r-in"><span><span class="va">fit.obs</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># The two-component error model has significantly higher likelihood</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.obs</span>, <span class="va">fit.tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model obs and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> 1 6 -64.983 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 6 -96.936 0 63.907 < 2.2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit.tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent k_m1 f_parent_to_m1 sigma_low </span> -<span class="r-out co"><span class="r-pr">#></span> 1.007343e+02 1.005562e-01 5.166712e-03 5.083933e-01 3.049883e-03 </span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high </span> -<span class="r-out co"><span class="r-pr">#></span> 7.928118e-02 </span> -<span class="r-in"><span><span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit.tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_m1 parent_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 0.5083933 0.4916067 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 6.89313 22.89848</span> -<span class="r-out co"><span class="r-pr">#></span> m1 134.15634 445.65772</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># We can show a quick (only one replication) benchmark for this case, as we</span></span></span> -<span class="r-in"><span><span class="co"># have several alternative solution methods for the model. We skip</span></span></span> -<span class="r-in"><span><span class="co"># uncompiled deSolve, as it is so slow. More benchmarks are found in the</span></span></span> -<span class="r-in"><span><span class="co"># benchmark vignette</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="kw">if</span><span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span>replications <span class="op">=</span> <span class="fl">1</span>, order <span class="op">=</span> <span class="st">"relative"</span>, columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> deSolve_compiled <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> eigen <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> analytical <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> test relative elapsed</span> -<span class="r-out co"><span class="r-pr">#></span> 3 analytical 1.000 0.236</span> -<span class="r-out co"><span class="r-pr">#></span> 1 deSolve_compiled 1.263 0.298</span> -<span class="r-out co"><span class="r-pr">#></span> 2 eigen 2.373 0.560</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Use stepwise fitting, using optimised parameters from parent only fit, FOMC-SFO</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">FOMC_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fit.FOMC_SFO</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Again, we get a warning and try a more sophisticated error model</span></span></span> -<span class="r-in"><span><span class="va">fit.FOMC_SFO.tc</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># This model has a higher likelihood, but not significantly so</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></span><span class="op">(</span><span class="va">fit.tc</span>, <span class="va">fit.FOMC_SFO.tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood ratio test</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model 1: FOMC_SFO with error model tc and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> Model 2: SFO_SFO with error model tc and fixed parameter(s) m1_0</span> -<span class="r-out co"><span class="r-pr">#></span> #Df LogLik Df Chisq Pr(>Chisq)</span> -<span class="r-out co"><span class="r-pr">#></span> 1 7 -64.829 </span> -<span class="r-out co"><span class="r-pr">#></span> 2 6 -64.983 -1 0.3075 0.5792</span> -<span class="r-in"><span><span class="co"># Also, the missing standard error for log_beta and the t-tests for alpha</span></span></span> -<span class="r-in"><span><span class="co"># and beta indicate overparameterisation</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.FOMC_SFO.tc</span>, data <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>NaNs produced</span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>diag(.) had 0 or NA entries; non-finite result is doubtful</span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:30:44 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:30:44 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * (alpha/beta) * 1/((time/beta) + 1) *</span> -<span class="r-out co"><span class="r-pr">#></span> parent - k_m1 * m1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type deSolve </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted using 3729 model solutions performed in 0.688 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model: Two-component variance function </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: d_3 </span> -<span class="r-out co"><span class="r-pr">#></span> Direct fitting and three-step fitting yield approximately the same likelihood </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 100.75 state</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 1.00 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> beta 10.00 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.10 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.50 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.10 error</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.10 error</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 100.750000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -2.302585 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.000000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 2.302585 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.100000 0 Inf</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.100000 0 Inf</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> m1_0 0 state</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 143.658 155.1211 -64.82902</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.600000 2.6400000 96.240000 107.000000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -5.284000 0.0929100 -5.474000 -5.095000</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.001426 0.0767000 -0.155000 0.157800</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 5.522000 0.0077320 5.506000 5.538000</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 7.806000 NaN NaN NaN</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.002488 0.0002431 0.001992 0.002984</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.079210 0.0093280 0.060180 0.098230</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_alpha log_beta</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000000 -0.095226 -0.76678 0.70544 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -0.095226 1.000000 0.51432 -0.14387 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.766780 0.514321 1.00000 -0.61396 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.705444 -0.143872 -0.61396 1.00000 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta NaN NaN NaN NaN 1</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 0.016073 0.001586 0.01548 5.87007 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 0.006626 -0.011700 -0.05357 0.04849 NaN</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low rsd_high</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 0.016073 0.006626</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 0.001586 -0.011700</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.015476 -0.053566</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 5.870075 0.048487</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta NaN NaN</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 1.000000 -0.652558</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high -0.652558 1.000000</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> -<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> -<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.016e+02 32.7800 6.311e-26 9.624e+01 1.070e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 5.072e-03 10.1200 1.216e-11 4.196e-03 6.130e-03</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 5.004e-01 20.8300 4.317e-20 4.613e-01 5.394e-01</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 2.502e+02 0.5624 2.889e-01 2.463e+02 2.542e+02</span> -<span class="r-out co"><span class="r-pr">#></span> beta 2.455e+03 0.5549 2.915e-01 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low 2.488e-03 0.4843 3.158e-01 1.992e-03 2.984e-03</span> -<span class="r-out co"><span class="r-pr">#></span> rsd_high 7.921e-02 8.4300 8.001e-10 6.018e-02 9.823e-02</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 6.781 5 14</span> -<span class="r-out co"><span class="r-pr">#></span> parent 7.141 3 6</span> -<span class="r-out co"><span class="r-pr">#></span> m1 4.640 2 8</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_m1 0.5004</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.4996</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> -<span class="r-out co"><span class="r-pr">#></span> parent 6.812 22.7 6.834</span> -<span class="r-out co"><span class="r-pr">#></span> m1 136.661 454.0 NA</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># We can easily use starting parameters from the parent only fit (only for illustration)</span></span></span> -<span class="r-in"><span><span class="va">fit.FOMC</span> <span class="op">=</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit.FOMC_SFO</span> <span class="op"><-</span> <span class="fu">mkinfit</span><span class="op">(</span><span class="va">FOMC_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>,</span></span> -<span class="r-in"><span> parms.ini <span class="op">=</span> <span class="va">fit.FOMC</span><span class="op">$</span><span class="va">bparms.ode</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinmod.html b/docs/dev/reference/mkinmod.html deleted file mode 100644 index 50ec64fa..00000000 --- a/docs/dev/reference/mkinmod.html +++ 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</div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Function to set up a kinetic model with one or more state variables</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinmod.R" class="external-link"><code>R/mkinmod.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinsub.R" class="external-link"><code>R/mkinsub.R</code></a></small> - <div class="hidden name"><code>mkinmod.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function is usually called using a call to <code>mkinsub()</code> for each observed -variable, specifying the corresponding submodel as well as outgoing pathways -(see examples).</p> -<p>Print mkinmod objects in a way that the user finds his way to get to its -components.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinmod</span><span class="op">(</span></span> -<span> <span class="va">...</span>,</span> -<span> use_of_ff <span class="op">=</span> <span class="st">"max"</span>,</span> -<span> name <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> speclist <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> dll_dir <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> unload <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> overwrite <span class="op">=</span> <span class="cn">FALSE</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinmod</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">mkinsub</span><span class="op">(</span><span class="va">submodel</span>, to <span class="op">=</span> <span class="cn">NULL</span>, sink <span class="op">=</span> <span class="cn">TRUE</span>, full_name <span class="op">=</span> <span class="cn">NA</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>...</dt> -<dd><p>For each observed variable, a list as obtained by <code>mkinsub()</code> -has to be specified as an argument (see examples). Currently, single -first order kinetics "SFO", indeterminate order rate equation kinetics -"IORE", or single first order with reversible binding "SFORB" are -implemented for all variables, while "FOMC", "DFOP", "HS" and "logistic" -can additionally be chosen for the first variable which is assumed to be -the source compartment. -Additionally, <code>mkinsub()</code> has an argument <code>to</code>, specifying names of -variables to which a transfer is to be assumed in the model. -If the argument <code>use_of_ff</code> is set to "min" -and the model for the compartment is "SFO" or "SFORB", an -additional <code>mkinsub()</code> argument can be <code>sink = FALSE</code>, effectively -fixing the flux to sink to zero. -In print.mkinmod, this argument is currently not used.</p></dd> - - -<dt>use_of_ff</dt> -<dd><p>Specification of the use of formation fractions in the -model equations and, if applicable, the coefficient matrix. If "max", -formation fractions are always used (default). If "min", a minimum use of -formation fractions is made, i.e. each first-order pathway to a metabolite -has its own rate constant.</p></dd> - - -<dt>name</dt> -<dd><p>A name for the model. Should be a valid R object name.</p></dd> - - -<dt>speclist</dt> -<dd><p>The specification of the observed variables and their -submodel types and pathways can be given as a single list using this -argument. Default is NULL.</p></dd> - - -<dt>quiet</dt> -<dd><p>Should messages be suppressed?</p></dd> - - -<dt>verbose</dt> -<dd><p>If <code>TRUE</code>, passed to <code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code> if -applicable to give detailed information about the C function being built.</p></dd> - - -<dt>dll_dir</dt> -<dd><p>Directory where an DLL object, if generated internally by -<code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code>, should be saved. The DLL will only be stored in a -permanent location for use in future sessions, if 'dll_dir' and 'name' -are specified. This is helpful if fit objects are cached e.g. by knitr, -as the cache remains functional across sessions if the DLL is stored in -a user defined location.</p></dd> - - -<dt>unload</dt> -<dd><p>If a DLL from the target location in 'dll_dir' is already -loaded, should that be unloaded first?</p></dd> - - -<dt>overwrite</dt> -<dd><p>If a file exists at the target DLL location in 'dll_dir', -should this be overwritten?</p></dd> - - -<dt>x</dt> -<dd><p>An <code>mkinmod</code> object.</p></dd> - - -<dt>submodel</dt> -<dd><p>Character vector of length one to specify the submodel type. -See <code>mkinmod</code> for the list of allowed submodel names.</p></dd> - - -<dt>to</dt> -<dd><p>Vector of the names of the state variable to which a -transformation shall be included in the model.</p></dd> - - -<dt>sink</dt> -<dd><p>Should a pathway to sink be included in the model in addition to -the pathways to other state variables?</p></dd> - - -<dt>full_name</dt> -<dd><p>An optional name to be used e.g. for plotting fits -performed with the model. You can use non-ASCII characters here, but then -your R code will not be portable, <em>i.e.</em> may produce unintended plot -results on other operating systems or system configurations.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A list of class <code>mkinmod</code> for use with <code><a href="mkinfit.html">mkinfit()</a></code>, -containing, among others,</p> -<dl><dt>diffs</dt> -<dd><p>A vector of string representations of differential equations, one for -each modelling variable.</p></dd> - -<dt>map</dt> -<dd><p>A list containing named character vectors for each observed variable, -specifying the modelling variables by which it is represented.</p></dd> - -<dt>use_of_ff</dt> -<dd><p>The content of <code>use_of_ff</code> is passed on in this list component.</p></dd> - -<dt>deg_func</dt> -<dd><p>If generated, a function containing the solution of the degradation -model.</p></dd> - -<dt>coefmat</dt> -<dd><p>The coefficient matrix, if the system of differential equations can be -represented by one.</p></dd> - -<dt>cf</dt> -<dd><p>If generated, a compiled function calculating the derivatives as -returned by cfunction.</p></dd> - - -</dl><p>A list for use with <code>mkinmod</code>.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>For the definition of model types and their parameters, the equations given -in the FOCUS and NAFTA guidance documents are used.</p> -<p>For kinetic models with more than one observed variable, a symbolic solution -of the system of differential equations is included in the resulting -mkinmod object in some cases, speeding up the solution.</p> -<p>If a C compiler is found by <code><a href="https://r-lib.github.io/pkgbuild/reference/has_compiler.html" class="external-link">pkgbuild::has_compiler()</a></code> and there -is more than one observed variable in the specification, C code is generated -for evaluating the differential equations, compiled using -<code><a href="https://rdrr.io/pkg/inline/man/cfunction.html" class="external-link">inline::cfunction()</a></code> and added to the resulting mkinmod object.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>The IORE submodel is not well tested for metabolites. When using this -model for metabolites, you may want to read the note in the help -page to <a href="mkinfit.html">mkinfit</a>.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> -<p>NAFTA Technical Working Group on Pesticides (not dated) Guidance for -Evaluating and Calculating Degradation Kinetics in Environmental Media</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Specify the SFO model (this is not needed any more, as we can now mkinfit("SFO", ...)</span></span></span> -<span class="r-in"><span><span class="va">SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span>parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># One parent compound, one metabolite, both single first order</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">SFO_SFO</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mkinmod> model generated with</span> -<span class="r-out co"><span class="r-pr">#></span> Use of formation fractions $use_of_ff: max </span> -<span class="r-out co"><span class="r-pr">#></span> Specification $spec:</span> -<span class="r-out co"><span class="r-pr">#></span> $parent</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $to: m1; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> $m1</span> -<span class="r-out co"><span class="r-pr">#></span> $type: SFO; $sink: TRUE</span> -<span class="r-out co"><span class="r-pr">#></span> Coefficient matrix $coefmat available</span> -<span class="r-out co"><span class="r-pr">#></span> Compiled model $cf available</span> -<span class="r-out co"><span class="r-pr">#></span> Differential equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * k_parent * parent - k_m1 * m1</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># Now supplying compound names used for plotting, and write to user defined location</span></span></span> -<span class="r-in"><span> <span class="co"># We need to choose a path outside the session tempdir because this gets removed</span></span></span> -<span class="r-in"><span> <span class="va">DLL_dir</span> <span class="op"><-</span> <span class="st">"~/.local/share/mkin"</span></span></span> -<span class="r-in"><span> <span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.exists</a></span><span class="op">(</span><span class="va">DLL_dir</span><span class="op">)</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/files2.html" class="external-link">dir.create</a></span><span class="op">(</span><span class="va">DLL_dir</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">SFO_SFO.2</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span>, full_name <span class="op">=</span> <span class="st">"Test compound"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, full_name <span class="op">=</span> <span class="st">"Metabolite M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> name <span class="op">=</span> <span class="st">"SFO_SFO"</span>, dll_dir <span class="op">=</span> <span class="va">DLL_dir</span>, unload <span class="op">=</span> <span class="cn">TRUE</span>, overwrite <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-msg co"><span class="r-pr">#></span> Copied DLL from /tmp/RtmpiGRJ6t/file5c7f7365e02a0.so to /home/jranke/.local/share/mkin/SFO_SFO.so</span> -<span class="r-in"><span><span class="co"># Now we can save the model and restore it in a new session</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/readRDS.html" class="external-link">saveRDS</a></span><span class="op">(</span><span class="va">SFO_SFO.2</span>, file <span class="op">=</span> <span class="st">"~/SFO_SFO.rds"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Terminate the R session here if you would like to check, and then do</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO.3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/readRDS.html" class="external-link">readRDS</a></span><span class="op">(</span><span class="st">"~/SFO_SFO.rds"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.3</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Show details of creating the C function</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Program source:</span> -<span class="r-out co"><span class="r-pr">#></span> 1: #include <R.h></span> -<span class="r-out co"><span class="r-pr">#></span> 2: </span> -<span class="r-out co"><span class="r-pr">#></span> 3: </span> -<span class="r-out co"><span class="r-pr">#></span> 4: static double parms [3];</span> -<span class="r-out co"><span class="r-pr">#></span> 5: #define k_parent parms[0]</span> -<span class="r-out co"><span class="r-pr">#></span> 6: #define f_parent_to_m1 parms[1]</span> -<span class="r-out co"><span class="r-pr">#></span> 7: #define k_m1 parms[2]</span> -<span class="r-out co"><span class="r-pr">#></span> 8: </span> -<span class="r-out co"><span class="r-pr">#></span> 9: void initpar(void (* odeparms)(int *, double *)) {</span> -<span class="r-out co"><span class="r-pr">#></span> 10: int N = 3;</span> -<span class="r-out co"><span class="r-pr">#></span> 11: odeparms(&N, parms);</span> -<span class="r-out co"><span class="r-pr">#></span> 12: }</span> -<span class="r-out co"><span class="r-pr">#></span> 13: </span> -<span class="r-out co"><span class="r-pr">#></span> 14: </span> -<span class="r-out co"><span class="r-pr">#></span> 15: void diffs ( int * n, double * t, double * y, double * f, double * rpar, int * ipar ) {</span> -<span class="r-out co"><span class="r-pr">#></span> 16: </span> -<span class="r-out co"><span class="r-pr">#></span> 17: f[0] = - k_parent * y[0];</span> -<span class="r-out co"><span class="r-pr">#></span> 18: f[1] = + f_parent_to_m1 * k_parent * y[0] - k_m1 * y[1];</span> -<span class="r-out co"><span class="r-pr">#></span> 19: }</span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The symbolic solution which is available in this case is not</span></span></span> -<span class="r-in"><span><span class="co"># made for human reading but for speed of computation</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span><span class="op">$</span><span class="va">deg_func</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> function (observed, odeini, odeparms) </span> -<span class="r-out co"><span class="r-pr">#></span> {</span> -<span class="r-out co"><span class="r-pr">#></span> predicted <- numeric(0)</span> -<span class="r-out co"><span class="r-pr">#></span> with(as.list(odeparms), {</span> -<span class="r-out co"><span class="r-pr">#></span> t <- observed[observed$name == "parent", "time"]</span> -<span class="r-out co"><span class="r-pr">#></span> predicted <<- c(predicted, SFO.solution(t, odeini["parent"], </span> -<span class="r-out co"><span class="r-pr">#></span> k_parent))</span> -<span class="r-out co"><span class="r-pr">#></span> t <- observed[observed$name == "m1", "time"]</span> -<span class="r-out co"><span class="r-pr">#></span> predicted <<- c(predicted, (((k_m1 - k_parent) * odeini["m1"] - </span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 * k_parent * odeini["parent"]) * exp(-k_m1 * </span> -<span class="r-out co"><span class="r-pr">#></span> t) + f_parent_to_m1 * k_parent * odeini["parent"] * </span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k_parent * t))/(k_m1 - k_parent))</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> return(predicted)</span> -<span class="r-out co"><span class="r-pr">#></span> }</span> -<span class="r-out co"><span class="r-pr">#></span> <environment: 0x555558bd6708></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># If we have several parallel metabolites</span></span></span> -<span class="r-in"><span><span class="co"># (compare tests/testthat/test_synthetic_data_for_UBA_2014.R)</span></span></span> -<span class="r-in"><span><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu">mkinmod</span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu">mkinsub</span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">fit_DFOP_par_c</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>,</span></span> -<span class="r-in"><span> <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">12</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinparplot-1.png b/docs/dev/reference/mkinparplot-1.png Binary files differdeleted file mode 100644 index 6e7bf34f..00000000 --- a/docs/dev/reference/mkinparplot-1.png +++ /dev/null diff --git a/docs/dev/reference/mkinparplot.html b/docs/dev/reference/mkinparplot.html deleted file mode 100644 index f7d404ef..00000000 --- a/docs/dev/reference/mkinparplot.html +++ /dev/null @@ -1,177 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by 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mkinfit</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinparplot.R" class="external-link"><code>R/mkinparplot.R</code></a></small> - <div class="hidden name"><code>mkinparplot.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function plots the confidence intervals for the parameters fitted using -<code><a href="mkinfit.html">mkinfit</a></code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinparplot</span><span class="op">(</span><span class="va">object</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> T245 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"phenol"</span><span class="op">)</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> phenol <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"anisole"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> anisole <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">mccall81_245T</span>, <span class="va">soil</span> <span class="op">==</span> <span class="st">"Commerce"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Optimisation did not converge:</span> -<span class="r-wrn co"><span class="r-pr">#></span> false convergence (8)</span> -<span class="r-in"><span><span class="fu">mkinparplot</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mkinparplot-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinplot.html b/docs/dev/reference/mkinplot.html deleted file mode 100644 index d83ea3f4..00000000 --- a/docs/dev/reference/mkinplot.html +++ /dev/null @@ -1,162 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta 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It now only calls the plot method -plot.mkinfit."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot the observed data and the fitted model of an mkinfit object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mkinfit.R" class="external-link"><code>R/plot.mkinfit.R</code></a></small> - <div class="hidden name"><code>mkinplot.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Deprecated function. It now only calls the plot method -<code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinplot</span><span class="op">(</span><span class="va">fit</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>fit</dt> -<dd><p>an object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>...</dt> -<dd><p>further arguments passed to <code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - 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</div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">x</span>, <span class="va">odeparms</span>, <span class="va">odeini</span>, <span class="va">outtimes</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinmod</span></span> -<span><span class="fu">mkinpredict</span><span class="op">(</span></span> -<span> <span class="va">x</span>,</span> -<span> odeparms <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent_sink <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> -<span> odeini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span> -<span> outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> use_symbols <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> method.ode <span class="op">=</span> <span class="st">"lsoda"</span>,</span> -<span> atol <span class="op">=</span> <span class="fl">1e-08</span>,</span> -<span> rtol <span class="op">=</span> <span class="fl">1e-10</span>,</span> -<span> maxsteps <span class="op">=</span> <span class="fl">20000L</span>,</span> -<span> map_output <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> na_stop <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu">mkinpredict</span><span class="op">(</span></span> -<span> <span class="va">x</span>,</span> -<span> odeparms <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.ode</span>,</span> -<span> odeini <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">bparms.state</span>,</span> -<span> outtimes <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">120</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span> -<span> use_compiled <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> method.ode <span class="op">=</span> <span class="st">"lsoda"</span>,</span> -<span> atol <span class="op">=</span> <span class="fl">1e-08</span>,</span> -<span> rtol <span class="op">=</span> <span class="fl">1e-10</span>,</span> -<span> map_output <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>A kinetic model as produced by <a href="mkinmod.html">mkinmod</a>, or a kinetic fit as -fitted by <a href="mkinfit.html">mkinfit</a>. In the latter case, the fitted parameters are used for -the prediction.</p></dd> - - -<dt>odeparms</dt> -<dd><p>A numeric vector specifying the parameters used in the -kinetic model, which is generally defined as a set of ordinary differential -equations.</p></dd> - - -<dt>odeini</dt> -<dd><p>A numeric vector containing the initial values of the state -variables of the model. Note that the state variables can differ from the -observed variables, for example in the case of the SFORB model.</p></dd> - - -<dt>outtimes</dt> -<dd><p>A numeric vector specifying the time points for which model -predictions should be generated.</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to the ode solver in case such a -solver is used.</p></dd> - - -<dt>solution_type</dt> -<dd><p>The method that should be used for producing the -predictions. This should generally be "analytical" if there is only one -observed variable, and usually "deSolve" in the case of several observed -variables. The third possibility "eigen" is fast in comparison to uncompiled -ODE models, but not applicable to some models, e.g. using FOMC for the -parent compound.</p></dd> - - -<dt>use_compiled</dt> -<dd><p>If set to <code>FALSE</code>, no compiled version of the -<a href="mkinmod.html">mkinmod</a> model is used, even if is present.</p></dd> - - -<dt>use_symbols</dt> -<dd><p>If set to <code>TRUE</code> (default), symbol info present in -the <a href="mkinmod.html">mkinmod</a> object is used if available for accessing compiled code</p></dd> - - -<dt>method.ode</dt> -<dd><p>The solution method passed via mkinpredict to ode] in -case the solution type is "deSolve" and we are not using compiled code. -When using compiled code, only lsoda is supported.</p></dd> - - -<dt>atol</dt> -<dd><p>Absolute error tolerance, passed to the ode solver.</p></dd> - - -<dt>rtol</dt> -<dd><p>Absolute error tolerance, passed to the ode solver.</p></dd> - - -<dt>maxsteps</dt> -<dd><p>Maximum number of steps, passed to the ode solver.</p></dd> - - -<dt>map_output</dt> -<dd><p>Boolean to specify if the output should list values for -the observed variables (default) or for all state variables (if set to -FALSE). Setting this to FALSE has no effect for analytical solutions, -as these always return mapped output.</p></dd> - - -<dt>na_stop</dt> -<dd><p>Should it be an error if ode returns NaN values</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A matrix with the numeric solution in wide format</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Compare solution types</span></span></span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> -<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> -<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> -<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> -<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> -<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> -<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> -<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> -<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> -<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> -<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> -<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> -<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108997</span> -<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> -<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> -<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> -<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> -<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> -<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> -<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> -<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> -<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> -<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> -<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> -<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> -<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> -<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> -<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> -<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> -<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108996</span> -<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> -<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> -<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> -<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> -<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> -<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> -<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> -<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> -<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> -<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> -<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> -<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> -<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> -<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> -<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> -<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> -<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108996</span> -<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> -<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> -<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> -<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> -<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol</span> -<span class="r-out co"><span class="r-pr">#></span> 0 0 100.0000000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 74.0818221</span> -<span class="r-out co"><span class="r-pr">#></span> 2 2 54.8811636</span> -<span class="r-out co"><span class="r-pr">#></span> 3 3 40.6569660</span> -<span class="r-out co"><span class="r-pr">#></span> 4 4 30.1194212</span> -<span class="r-out co"><span class="r-pr">#></span> 5 5 22.3130160</span> -<span class="r-out co"><span class="r-pr">#></span> 6 6 16.5298888</span> -<span class="r-out co"><span class="r-pr">#></span> 7 7 12.2456428</span> -<span class="r-out co"><span class="r-pr">#></span> 8 8 9.0717953</span> -<span class="r-out co"><span class="r-pr">#></span> 9 9 6.7205513</span> -<span class="r-out co"><span class="r-pr">#></span> 10 10 4.9787068</span> -<span class="r-out co"><span class="r-pr">#></span> 11 11 3.6883167</span> -<span class="r-out co"><span class="r-pr">#></span> 12 12 2.7323722</span> -<span class="r-out co"><span class="r-pr">#></span> 13 13 2.0241911</span> -<span class="r-out co"><span class="r-pr">#></span> 14 14 1.4995577</span> -<span class="r-out co"><span class="r-pr">#></span> 15 15 1.1108997</span> -<span class="r-out co"><span class="r-pr">#></span> 16 16 0.8229747</span> -<span class="r-out co"><span class="r-pr">#></span> 17 17 0.6096747</span> -<span class="r-out co"><span class="r-pr">#></span> 18 18 0.4516581</span> -<span class="r-out co"><span class="r-pr">#></span> 19 19 0.3345965</span> -<span class="r-out co"><span class="r-pr">#></span> 20 20 0.2478752</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Compare integration methods to analytical solution</span></span></span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"analytical"</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> method <span class="op">=</span> <span class="st">"lsoda"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> method <span class="op">=</span> <span class="st">"ode45"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, <span class="fl">0</span><span class="op">:</span><span class="fl">20</span>,</span></span> -<span class="r-in"><span> method <span class="op">=</span> <span class="st">"rk4"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">21</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2480043 </span> -<span class="r-in"><span><span class="co"># rk4 is not as precise here</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The number of output times used to make a lot of difference until the</span></span></span> -<span class="r-in"><span><span class="co"># default for atol was adjusted</span></span></span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> -<span class="r-in"><span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_degradinol <span class="op">=</span> <span class="fl">0.3</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>degradinol <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span><span class="op">)</span><span class="op">[</span><span class="fl">2001</span>,<span class="op">]</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> time degradinol </span> -<span class="r-out co"><span class="r-pr">#></span> 20.0000000 0.2478752 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Comparison of the performance of solution types</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="kw">if</span><span class="op">(</span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">require</a></span><span class="op">(</span><span class="va"><a href="http://rbenchmark.googlecode.com" class="external-link">rbenchmark</a></span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/rbenchmark/man/benchmark.html" class="external-link">benchmark</a></span><span class="op">(</span>replications <span class="op">=</span> <span class="fl">10</span>, order <span class="op">=</span> <span class="st">"relative"</span>, columns <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"test"</span>, <span class="st">"relative"</span>, <span class="st">"elapsed"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> eigen <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"eigen"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span> -<span class="r-in"><span> deSolve_compiled <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span> -<span class="r-in"><span> deSolve <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span>,</span></span> -<span class="r-in"><span> analytical <span class="op">=</span> <span class="fu">mkinpredict</span><span class="op">(</span><span class="va">SFO_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.15</span>, f_parent_to_m1 <span class="op">=</span> <span class="fl">0.5</span>, k_m1 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">20</span>, by <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"analytical"</span>, use_compiled <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span><span class="op">[</span><span class="fl">201</span>,<span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Loading required package: rbenchmark</span> -<span class="r-out co"><span class="r-pr">#></span> test relative elapsed</span> -<span class="r-out co"><span class="r-pr">#></span> 2 deSolve_compiled 1.00 0.004</span> -<span class="r-out co"><span class="r-pr">#></span> 1 eigen 4.00 0.016</span> -<span class="r-out co"><span class="r-pr">#></span> 4 analytical 4.25 0.017</span> -<span class="r-out co"><span class="r-pr">#></span> 3 deSolve 40.75 0.163</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="co"># Predict from a fitted model</span></span></span> -<span class="r-in"><span> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="fu">mkinpredict</span><span class="op">(</span><span class="va">f</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in !is.null(x$symbols) & use_symbols:</span> operations are possible only for numeric, logical or complex types</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mkinresplot-1.png b/docs/dev/reference/mkinresplot-1.png Binary files differdeleted file mode 100644 index 7c64d0f0..00000000 --- a/docs/dev/reference/mkinresplot-1.png +++ /dev/null diff --git a/docs/dev/reference/mkinresplot.html b/docs/dev/reference/mkinresplot.html deleted file mode 100644 index e73ac93c..00000000 --- a/docs/dev/reference/mkinresplot.html +++ /dev/null @@ -1,248 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Function to plot residuals stored in an mkin object — mkinresplot • mkin</title><!-- jquery --><script 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property="og:description" content="This function plots the residuals for the specified subset of the observed -variables from an mkinfit object. A combined plot of the fitted model and -the residuals can be obtained using plot.mkinfit using the -argument show_residuals = TRUE."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Function to plot residuals stored in an mkin object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/mkinresplot.R" class="external-link"><code>R/mkinresplot.R</code></a></small> - <div class="hidden name"><code>mkinresplot.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function plots the residuals for the specified subset of the observed -variables from an mkinfit object. A combined plot of the fitted model and -the residuals can be obtained using <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> using the -argument <code>show_residuals = TRUE</code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mkinresplot</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>,</span> -<span> xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1.1</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="va">object</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span><span class="op">)</span>,</span> -<span> standardized <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> xlab <span class="op">=</span> <span class="st">"Time"</span>,</span> -<span> ylab <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="va">standardized</span>, <span class="st">"Standardized residual"</span>, <span class="st">"Residual"</span><span class="op">)</span>,</span> -<span> maxabs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> legend <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"topright"</span>,</span> -<span> col_obs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> pch_obs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> frame <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A fit represented in an <code><a href="mkinfit.html">mkinfit</a></code> object.</p></dd> - - -<dt>obs_vars</dt> -<dd><p>A character vector of names of the observed variables for -which residuals should be plotted. Defaults to all observed variables in -the model</p></dd> - - -<dt>xlim</dt> -<dd><p>plot range in x direction.</p></dd> - - -<dt>standardized</dt> -<dd><p>Should the residuals be standardized by dividing by the -standard deviation given by the error model of the fit?</p></dd> - - -<dt>xlab</dt> -<dd><p>Label for the x axis.</p></dd> - - -<dt>ylab</dt> -<dd><p>Label for the y axis.</p></dd> - - -<dt>maxabs</dt> -<dd><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></dd> - - -<dt>legend</dt> -<dd><p>Should a legend be plotted?</p></dd> - - -<dt>lpos</dt> -<dd><p>Where should the legend be placed? Default is "topright". Will -be passed on to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code>.</p></dd> - - -<dt>col_obs</dt> -<dd><p>Colors for the observed variables.</p></dd> - - -<dt>pch_obs</dt> -<dd><p>Symbols to be used for the observed variables.</p></dd> - - -<dt>frame</dt> -<dd><p>Should a frame be drawn around the plots?</p></dd> - - -<dt>...</dt> -<dd><p>further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Nothing is returned by this function, as it is called for its side -effect, namely to produce a plot.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code><a href="mkinplot.html">mkinplot</a></code>, for a way to plot the data and the fitted -lines of the mkinfit object, and <code><a href="plot.mkinfit.html">plot_res</a></code> for a function -combining the plot of the fit and the residual plot.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke and Katrin Lindenberger</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span><span class="op">)</span>, m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span><span class="fu">mkinresplot</span><span class="op">(</span><span class="va">fit</span>, <span class="st">"m1"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mkinresplot-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/mmkin-1.png b/docs/dev/reference/mmkin-1.png Binary files differdeleted file mode 100644 index dae64316..00000000 --- a/docs/dev/reference/mmkin-1.png +++ /dev/null diff --git a/docs/dev/reference/mmkin-2.png b/docs/dev/reference/mmkin-2.png Binary files differdeleted file mode 100644 index b281cd7e..00000000 --- a/docs/dev/reference/mmkin-2.png +++ /dev/null diff --git a/docs/dev/reference/mmkin-3.png b/docs/dev/reference/mmkin-3.png Binary files differdeleted file mode 100644 index 23b0725c..00000000 --- a/docs/dev/reference/mmkin-3.png +++ /dev/null diff --git a/docs/dev/reference/mmkin-4.png b/docs/dev/reference/mmkin-4.png Binary files differdeleted file mode 100644 index 11eae1f9..00000000 --- a/docs/dev/reference/mmkin-4.png +++ /dev/null diff --git a/docs/dev/reference/mmkin-5.png b/docs/dev/reference/mmkin-5.png Binary files differdeleted file mode 100644 index e88bd59f..00000000 --- a/docs/dev/reference/mmkin-5.png +++ /dev/null diff --git a/docs/dev/reference/mmkin.html b/docs/dev/reference/mmkin.html deleted file mode 100644 index 64623f20..00000000 --- a/docs/dev/reference/mmkin.html +++ /dev/null @@ -1,289 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Fit one or more kinetic models with one or more state variables to one or -more datasets — mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Fit one or more kinetic models with one or more state variables to one or -more datasets — mmkin"><meta property="og:description" content="This function calls mkinfit on all combinations of models and -datasets specified in its first two arguments."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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</div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">mmkin</span><span class="op">(</span></span> -<span> models <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span> -<span> <span class="va">datasets</span>,</span> -<span> cores <span class="op">=</span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="fl">1</span> <span class="kw">else</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> cluster <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>models</dt> -<dd><p>Either a character vector of shorthand names like -<code>c("SFO", "FOMC", "DFOP", "HS", "SFORB")</code>, or an optionally named -list of <code><a href="mkinmod.html">mkinmod</a></code> objects.</p></dd> - - -<dt>datasets</dt> -<dd><p>An optionally named list of datasets suitable as observed -data for <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>cores</dt> -<dd><p>The number of cores to be used for multicore processing. This -is only used when the <code>cluster</code> argument is <code>NULL</code>. On Windows -machines, cores > 1 is not supported, you need to use the <code>cluster</code> -argument to use multiple logical processors. Per default, all cores -detected by <code><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">parallel::detectCores()</a></code> are used, except on Windows where -the default is 1.</p></dd> - - -<dt>cluster</dt> -<dd><p>A cluster as returned by <code>makeCluster</code> to be used -for parallel execution.</p></dd> - - -<dt>...</dt> -<dd><p>Not used.</p></dd> - - -<dt>x</dt> -<dd><p>An mmkin object.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A two-dimensional <code><a href="https://rdrr.io/r/base/array.html" class="external-link">array</a></code> of <code><a href="mkinfit.html">mkinfit</a></code></p> - - -<p>objects and/or try-errors that can be indexed using the model names for the -first index (row index) and the dataset names for the second index (column -index).</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code><a href="Extract.mmkin.html">[.mmkin</a></code> for subsetting, <code><a href="plot.mmkin.html">plot.mmkin</a></code> for -plotting.</p></div> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">m_synth_FOMC_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">models</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>SFO_lin <span class="op">=</span> <span class="va">m_synth_SFO_lin</span>, FOMC_lin <span class="op">=</span> <span class="va">m_synth_FOMC_lin</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">datasets</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">synthetic_data_for_UBA_2014</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">datasets</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">time_default</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">fits.0</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">time_1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/system.time.html" class="external-link">system.time</a></span><span class="op">(</span><span class="va">fits.4</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="va">models</span>, <span class="va">datasets</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">time_default</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> -<span class="r-out co"><span class="r-pr">#></span> 1.560 0.668 0.742 </span> -<span class="r-in"><span><span class="va">time_1</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> user system elapsed </span> -<span class="r-out co"><span class="r-pr">#></span> 2.033 0.004 2.037 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="st">"SFO_lin"</span>, <span class="fl">2</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_M1 parent_sink M1_M2 M1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 0.7340481 0.2659519 0.7505683 0.2494317 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 0.877769 2.915885</span> -<span class="r-out co"><span class="r-pr">#></span> M1 2.325744 7.725956</span> -<span class="r-out co"><span class="r-pr">#></span> M2 33.720100 112.015749</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># plot.mkinfit handles rows or columns of mmkin result objects</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="op">]</span>, obs_var <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span>, <span class="fl">1</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mmkin-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># Use double brackets to extract a single mkinfit object, which will be plotted</span></span></span> -<span class="r-in"><span><span class="co"># by plot.mkinfit and can be plotted using plot_sep</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mmkin-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Plotting with mmkin (single brackets, extracting an mmkin object) does not</span></span></span> -<span class="r-in"><span><span class="co"># allow to plot the observed variables separately</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits.0</span><span class="op">[</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="mmkin-5.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># On Windows, we can use multiple cores by making a cluster first</span></span></span> -<span class="r-in"><span><span class="va">cl</span> <span class="op"><-</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="fl">12</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu">mmkin</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>A <span class="op">=</span> <span class="va">FOCUS_2006_A</span>, B <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, C <span class="op">=</span> <span class="va">FOCUS_2006_C</span>, D <span class="op">=</span> <span class="va">FOCUS_2006_D</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> cluster <span class="op">=</span> <span class="va">cl</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> <mmkin> object</span> -<span class="r-out co"><span class="r-pr">#></span> Status of individual fits:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model A B C D </span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP OK OK OK OK</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span><span class="co"># We get false convergence for the FOMC fit to FOCUS_2006_A because this</span></span></span> -<span class="r-in"><span><span class="co"># dataset is really SFO, and the FOMC fit is overparameterised</span></span></span> -<span class="r-in"><span><span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div 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It is -inspired by the article on practical identifiabiliy in the frame of nonlinear -mixed-effects models by Duchesne et al (2021).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">multistart</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> n <span class="op">=</span> <span class="fl">50</span>,</span> -<span> cores <span class="op">=</span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/Sys.info.html" class="external-link">Sys.info</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"sysname"</span><span class="op">]</span> <span class="op">==</span> <span class="st">"Windows"</span><span class="op">)</span> <span class="fl">1</span> <span class="kw">else</span> <span class="fu">parallel</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/parallel/detectCores.html" class="external-link">detectCores</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> cluster <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu">multistart</span><span class="op">(</span><span class="va">object</span>, n <span class="op">=</span> <span class="fl">50</span>, cores <span class="op">=</span> <span class="fl">1</span>, cluster <span class="op">=</span> <span class="cn">NULL</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for multistart</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">best</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for default</span></span> -<span><span class="fu">best</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">which.best</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for default</span></span> -<span><span class="fu">which.best</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The fit object to work with</p></dd> - - -<dt>n</dt> -<dd><p>How many different combinations of starting parameters should be -used?</p></dd> - - -<dt>cores</dt> -<dd><p>How many fits should be run in parallel (only on posix platforms)?</p></dd> - - -<dt>cluster</dt> -<dd><p>A cluster as returned by <a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">parallel::makeCluster</a> to be used -for parallel execution.</p></dd> - - -<dt>...</dt> -<dd><p>Passed to the update function.</p></dd> - - -<dt>x</dt> -<dd><p>The multistart object to print</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A list of <a href="saem.html">saem.mmkin</a> objects, with class attributes -'multistart.saem.mmkin' and 'multistart'.</p> - - -<p>The object with the highest likelihood</p> - - -<p>The index of the object with the highest likelihood</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="parplot.html">parplot</a>, <a href="llhist.html">llhist</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://pkgdown.jrwb.de/mkin/">mkin</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">7</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span> <span class="op"><-</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span><span class="op">[[</span><span class="va">i</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span><span class="op">[</span><span class="va">ds_i</span><span class="op">$</span><span class="va">name</span> <span class="op">==</span> <span class="st">"DMTAP"</span>, <span class="st">"name"</span><span class="op">]</span> <span class="op"><-</span> <span class="st">"DMTA"</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op"><-</span> <span class="va">ds_i</span><span class="op">$</span><span class="va">time</span> <span class="op">*</span> <span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">f_time_norm</span><span class="op">[</span><span class="va">i</span><span class="op">]</span></span></span> -<span class="r-in"><span> <span class="va">ds_i</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">sapply</a></span><span class="op">(</span><span class="va">dimethenamid_2018</span><span class="op">$</span><span class="va">ds</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="va">ds</span><span class="op">$</span><span class="va">title</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/cbind.html" class="external-link">rbind</a></span><span class="op">(</span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span>, <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 1"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="va">dmta_ds</span><span class="op">[[</span><span class="st">"Elliot 2"</span><span class="op">]</span><span class="op">]</span> <span class="op"><-</span> <span class="cn">NULL</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">dmta_ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">7</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_full</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_full_multi</span> <span class="op"><-</span> <span class="fu">multistart</span><span class="op">(</span><span class="va">f_saem_full</span>, n <span class="op">=</span> <span class="fl">16</span>, cores <span class="op">=</span> <span class="fl">16</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_full_multi</span>, lpos <span class="op">=</span> <span class="st">"topleft"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="multistart-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_full</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] "sd(log_k2)"</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_saem_reduced</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_full</span>, no_random_effect <span class="op">=</span> <span class="st">"log_k2"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_reduced</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># On Windows, we need to create a PSOCK cluster first and refer to it</span></span></span> -<span class="r-in"><span><span class="co"># in the call to multistart()</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">parallel</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">cl</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">makePSOCKcluster</a></span><span class="op">(</span><span class="fl">12</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_reduced_multi</span> <span class="op"><-</span> <span class="fu">multistart</span><span class="op">(</span><span class="va">f_saem_reduced</span>, n <span class="op">=</span> <span class="fl">16</span>, cluster <span class="op">=</span> <span class="va">cl</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="parplot.html">parplot</a></span><span class="op">(</span><span class="va">f_saem_reduced_multi</span>, lpos <span class="op">=</span> <span class="st">"topright"</span>, ylim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">2</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="multistart-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/parallel/makeCluster.html" class="external-link">stopCluster</a></span><span class="op">(</span><span class="va">cl</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - 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The results for the three models are printed in the -order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Evaluate parent kinetics using the NAFTA guidance</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nafta.R" class="external-link"><code>R/nafta.R</code></a></small> - <div class="hidden name"><code>nafta.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The function fits the SFO, IORE and DFOP models using <code><a href="mmkin.html">mmkin</a></code> -and returns an object of class <code>nafta</code> that has methods for printing -and plotting.</p> -<p>Print nafta objects. The results for the three models are printed in the -order of increasing model complexity, i.e. SFO, then IORE, and finally DFOP.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">nafta</span><span class="op">(</span><span class="va">ds</span>, title <span class="op">=</span> <span class="cn">NA</span>, quiet <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for nafta</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, digits <span class="op">=</span> <span class="fl">3</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="source"> - <h2>Source</h2> - <p>NAFTA (2011) Guidance for evaluating and calculating degradation -kinetics in environmental media. NAFTA Technical Working Group on -Pesticides -<a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/guidance-evaluating-and-calculating-degradation</a> -accessed 2019-02-22</p> -<p>US EPA (2015) Standard Operating Procedure for Using the NAFTA Guidance to -Calculate Representative Half-life Values and Characterizing Pesticide -Degradation -<a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance" class="external-link">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/standard-operating-procedure-using-nafta-guidance</a></p> - </div> - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>ds</dt> -<dd><p>A dataframe that must contain one variable called "time" with the -time values specified by the <code>time</code> argument, one column called -"name" with the grouping of the observed values, and finally one column of -observed values called "value".</p></dd> - - -<dt>title</dt> -<dd><p>Optional title of the dataset</p></dd> - - -<dt>quiet</dt> -<dd><p>Should the evaluation text be shown?</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to <code><a href="mmkin.html">mmkin</a></code> (not for the -printing method).</p></dd> - - -<dt>x</dt> -<dd><p>An <code>nafta</code> object.</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to be used for printing parameters and -dissipation times.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An list of class <code>nafta</code>. The list element named "mmkin" is the -<code><a href="mmkin.html">mmkin</a></code> object containing the fits of the three models. The -list element named "title" contains the title of the dataset used. The -list element "data" contains the dataset used in the fits.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">nafta_evaluation</span> <span class="op"><-</span> <span class="fu">nafta</span><span class="op">(</span><span class="va">NAFTA_SOP_Appendix_D</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> The SFO model is rejected as S_SFO is equal or higher than the critical value S_c</span> -<span class="r-msg co"><span class="r-pr">#></span> The representative half-life of the IORE model is longer than the one corresponding</span> -<span class="r-msg co"><span class="r-pr">#></span> to the terminal degradation rate found with the DFOP model.</span> -<span class="r-msg co"><span class="r-pr">#></span> The representative half-life obtained from the DFOP model may be used</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Sums of squares:</span> -<span class="r-out co"><span class="r-pr">#></span> SFO IORE DFOP </span> -<span class="r-out co"><span class="r-pr">#></span> 1378.6832 615.7730 517.8836 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Critical sum of squares for checking the SFO model:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 717.4598</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 83.7558 1.80e-14 77.18268 90.3288</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0017 7.43e-05 0.00112 0.0026</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 8.7518 1.22e-05 5.64278 11.8608</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $IORE</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 9.69e+01 NA 8.88e+01 1.05e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k__iore_parent 8.40e-14 NA 1.79e-18 3.94e-09</span> -<span class="r-out co"><span class="r-pr">#></span> N_parent 6.68e+00 NA 4.19e+00 9.17e+00</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.85e+00 NA 3.76e+00 7.94e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 9.76e+01 1.94e-13 9.02e+01 1.05e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k1 4.24e-02 5.92e-03 2.03e-02 8.88e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k2 8.24e-04 6.48e-03 3.89e-04 1.75e-03</span> -<span class="r-out co"><span class="r-pr">#></span> g 2.88e-01 2.47e-05 1.95e-01 4.03e-01</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.36e+00 2.22e-05 3.43e+00 7.30e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> DTx values:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50_rep</span> -<span class="r-out co"><span class="r-pr">#></span> SFO 407 1350 407</span> -<span class="r-out co"><span class="r-pr">#></span> IORE 541 5190000 1560000</span> -<span class="r-out co"><span class="r-pr">#></span> DFOP 429 2380 841</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Representative half-life:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] 841.41</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">nafta_evaluation</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nafta-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/nlme-1.png b/docs/dev/reference/nlme-1.png Binary files differdeleted file mode 100644 index 9583da2a..00000000 --- a/docs/dev/reference/nlme-1.png +++ /dev/null diff --git a/docs/dev/reference/nlme-2.png b/docs/dev/reference/nlme-2.png Binary files differdeleted file mode 100644 index e941687c..00000000 --- a/docs/dev/reference/nlme-2.png +++ /dev/null diff --git a/docs/dev/reference/nlme.html b/docs/dev/reference/nlme.html deleted file mode 100644 index 81c45ab9..00000000 --- a/docs/dev/reference/nlme.html +++ /dev/null @@ -1,244 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Helper functions to create nlme models from mmkin row objects — nlme_function • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Helper functions to create nlme models from mmkin row objects — nlme_function"><meta property="og:description" content="These functions facilitate setting up a nonlinear mixed effects model for -an mmkin row object. 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An mmkin row object is essentially a list of mkinfit -objects that have been obtained by fitting the same model to a list of -datasets. They are used internally by the <code><a href="nlme.mmkin.html">nlme.mmkin()</a></code> method.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">nlme_function</span><span class="op">(</span><span class="va">object</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">nlme_data</span><span class="op">(</span><span class="va">object</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An mmkin row object containing several fits of the same model to different datasets</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A function that can be used with nlme</p> - - -<p>A <code><a href="https://rdrr.io/pkg/nlme/man/groupedData.html" class="external-link">groupedData</a></code> object</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code><a href="nlme.mmkin.html">nlme.mmkin</a></code></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">m_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_1</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">98</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_1_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_1</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_2</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">102</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_2_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_2</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_3</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">103</span><span class="op">)</span>, <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_SFO_3_long</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">d_SFO_3</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d1</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_1</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">3</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d2</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_2</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">2</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d3</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_SFO_3</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">4</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>d1 <span class="op">=</span> <span class="va">d1</span>, d2 <span class="op">=</span> <span class="va">d2</span>, d3 <span class="op">=</span> <span class="va">d3</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">ds</span>, cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">mean_dp</span> <span class="op"><-</span> <span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">grouped_data</span> <span class="op"><-</span> <span class="fu">nlme_data</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">nlme_f</span> <span class="op"><-</span> <span class="fu">nlme_function</span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># These assignments are necessary for these objects to be</span></span></span> -<span class="r-in"><span><span class="co"># visible to nlme and augPred when evaluation is done by</span></span></span> -<span class="r-in"><span><span class="co"># pkgdown to generate the html docs.</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="st">"nlme_f"</span>, <span class="va">nlme_f</span>, <span class="fu"><a href="https://rdrr.io/r/base/environment.html" class="external-link">globalenv</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="st">"grouped_data"</span>, <span class="va">grouped_data</span>, <span class="fu"><a href="https://rdrr.io/r/base/environment.html" class="external-link">globalenv</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">m_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu">nlme_f</span><span class="op">(</span><span class="va">name</span>, <span class="va">time</span>, <span class="va">parent_0</span>, <span class="va">log_k_parent_sink</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> data <span class="op">=</span> <span class="va">grouped_data</span>,</span></span> -<span class="r-in"><span> fixed <span class="op">=</span> <span class="va">parent_0</span> <span class="op">+</span> <span class="va">log_k_parent_sink</span> <span class="op">~</span> <span class="fl">1</span>,</span></span> -<span class="r-in"><span> random <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">pdDiag</a></span><span class="op">(</span><span class="va">parent_0</span> <span class="op">+</span> <span class="va">log_k_parent_sink</span> <span class="op">~</span> <span class="fl">1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> start <span class="op">=</span> <span class="va">mean_dp</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">m_nlme</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Nonlinear mixed-effects model fit by maximum likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> Model: value ~ nlme_f(name, time, parent_0, log_k_parent_sink) </span> -<span class="r-out co"><span class="r-pr">#></span> Data: grouped_data </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 266.6428 275.8935 -128.3214</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1)</span> -<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink Residual</span> -<span class="r-out co"><span class="r-pr">#></span> StdDev: 0.0004253489 0.7058039 3.065183</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects: parent_0 + log_k_parent_sink ~ 1 </span> -<span class="r-out co"><span class="r-pr">#></span> Value Std.Error DF t-value p-value</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.18323 0.7900461 43 128.07256 0</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink -3.08708 0.4171755 43 -7.39995 0</span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> prnt_0</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink 0.031 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Standardized Within-Group Residuals:</span> -<span class="r-out co"><span class="r-pr">#></span> Min Q1 Med Q3 Max </span> -<span class="r-out co"><span class="r-pr">#></span> -2.38427071 -0.52059848 0.03593021 0.39987268 2.73188969 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Number of Observations: 47</span> -<span class="r-out co"><span class="r-pr">#></span> Number of Groups: 3 </span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/augPred.html" class="external-link">augPred</a></span><span class="op">(</span><span class="va">m_nlme</span>, level <span class="op">=</span> <span class="fl">0</span><span class="op">:</span><span class="fl">1</span><span class="op">)</span>, layout <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fl">1</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nlme-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># augPred does not work on fits with more than one state</span></span></span> -<span class="r-in"><span><span class="co"># variable</span></span></span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># The procedure is greatly simplified by the nlme.mmkin function</span></span></span> -<span class="r-in"><span><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nlme-2.png" alt="" width="700" height="433"></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/nlme.mmkin-1.png b/docs/dev/reference/nlme.mmkin-1.png Binary files differdeleted file mode 100644 index 818c23a2..00000000 --- a/docs/dev/reference/nlme.mmkin-1.png +++ /dev/null diff --git a/docs/dev/reference/nlme.mmkin-2.png b/docs/dev/reference/nlme.mmkin-2.png Binary files differdeleted file mode 100644 index 779adbdb..00000000 --- a/docs/dev/reference/nlme.mmkin-2.png +++ /dev/null diff --git a/docs/dev/reference/nlme.mmkin-3.png b/docs/dev/reference/nlme.mmkin-3.png Binary files differdeleted file mode 100644 index b3785a78..00000000 --- a/docs/dev/reference/nlme.mmkin-3.png +++ /dev/null diff --git a/docs/dev/reference/nlme.mmkin.html b/docs/dev/reference/nlme.mmkin.html deleted file mode 100644 index 76d667b9..00000000 --- a/docs/dev/reference/nlme.mmkin.html +++ /dev/null @@ -1,464 +0,0 @@ -<!DOCTYPE html> 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An mmkin row object is essentially a list of mkinfit objects that -have been obtained by fitting the same model to a list of datasets."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Create an nlme model for an mmkin row object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.mmkin.R" class="external-link"><code>R/nlme.mmkin.R</code></a></small> - <div class="hidden name"><code>nlme.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This functions sets up a nonlinear mixed effects model for an mmkin row -object. An mmkin row object is essentially a list of mkinfit objects that -have been obtained by fitting the same model to a list of datasets.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span></span> -<span> <span class="va">model</span>,</span> -<span> data <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> fixed <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">as.list</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">model</span><span class="op">)</span><span class="op">)</span><span class="op">)</span>, <span class="kw">function</span><span class="op">(</span><span class="va">el</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/eval.html" class="external-link">eval</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/parse.html" class="external-link">parse</a></span><span class="op">(</span>text <span class="op">=</span></span> -<span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="va">el</span>, <span class="fl">1</span>, sep <span class="op">=</span> <span class="st">"~"</span><span class="op">)</span><span class="op">)</span><span class="op">)</span><span class="op">)</span>,</span> -<span> random <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">pdDiag</a></span><span class="op">(</span><span class="va">fixed</span><span class="op">)</span>,</span> -<span> <span class="va">groups</span>,</span> -<span> start <span class="op">=</span> <span class="fu"><a href="mean_degparms.html">mean_degparms</a></span><span class="op">(</span><span class="va">model</span>, random <span class="op">=</span> <span class="cn">TRUE</span>, test_log_parms <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> correlation <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> weights <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> <span class="va">subset</span>,</span> -<span> method <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"ML"</span>, <span class="st">"REML"</span><span class="op">)</span>,</span> -<span> na.action <span class="op">=</span> <span class="va">na.fail</span>,</span> -<span> <span class="va">naPattern</span>,</span> -<span> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for nlme.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for nlme.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>model</dt> -<dd><p>An <a href="mmkin.html">mmkin</a> row object.</p></dd> - - -<dt>data</dt> -<dd><p>Ignored, data are taken from the mmkin model</p></dd> - - -<dt>fixed</dt> -<dd><p>Ignored, all degradation parameters fitted in the -mmkin model are used as fixed parameters</p></dd> - - -<dt>random</dt> -<dd><p>If not specified, no correlations between random effects are -set up for the optimised degradation model parameters. This is -achieved by using the <a href="https://rdrr.io/pkg/nlme/man/pdDiag.html" class="external-link">nlme::pdDiag</a> method.</p></dd> - - -<dt>groups</dt> -<dd><p>See the documentation of nlme</p></dd> - - -<dt>start</dt> -<dd><p>If not specified, mean values of the fitted degradation -parameters taken from the mmkin object are used</p></dd> - - -<dt>correlation</dt> -<dd><p>See the documentation of nlme</p></dd> - - -<dt>weights</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>subset</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>method</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>na.action</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>naPattern</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>control</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>verbose</dt> -<dd><p>passed to nlme</p></dd> - - -<dt>x</dt> -<dd><p>An nlme.mmkin object to print</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> - - -<dt>...</dt> -<dd><p>Update specifications passed to update.nlme</p></dd> - - -<dt>object</dt> -<dd><p>An nlme.mmkin object to update</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Upon success, a fitted 'nlme.mmkin' object, which is an nlme object -with additional elements. It also inherits from 'mixed.mmkin'.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>Note that the convergence of the nlme algorithms depends on the quality -of the data. In degradation kinetics, we often only have few datasets -(e.g. data for few soils) and complicated degradation models, which may -make it impossible to obtain convergence with nlme.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>As the object inherits from <a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme::nlme</a>, there is a wealth of -methods that will automatically work on 'nlme.mmkin' objects, such as -<code><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">nlme::intervals()</a></code>, <code><a href="https://rdrr.io/pkg/nlme/man/anova.lme.html" class="external-link">nlme::anova.lme()</a></code> and <code><a href="https://rdrr.io/pkg/nlme/man/coef.lme.html" class="external-link">nlme::coef.lme()</a></code>.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><code><a href="nlme.html">nlme_function()</a></code>, <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a>, <a href="summary.nlme.mmkin.html">summary.nlme.mmkin</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span>, <span class="va">name</span> <span class="op">==</span> <span class="st">"parent"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_dfop</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_sfo</span>, <span class="va">f_nlme_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio p-value</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_sfo 1 5 625.0539 637.5529 -307.5269 </span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop 2 9 495.1270 517.6253 -238.5635 1 vs 2 137.9268 <.0001</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -238.6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> -<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) </span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis </span> -<span class="r-out co"><span class="r-pr">#></span> 94.1702 -1.8002 -4.1474 0.0324 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)</span> -<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis Residual</span> -<span class="r-out co"><span class="r-pr">#></span> StdDev: 2.488 0.8447 1.33 0.4652 2.321</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nlme.mmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 10.79857 100.7937 30.34192 4.193936 43.85441</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">ds_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">m_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"min"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">m_sfo_sfo_ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">m_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_2</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">m_sfo_sfo</span>,</span></span> -<span class="r-in"><span> <span class="st">"SFO-SFO-ff"</span> <span class="op">=</span> <span class="va">m_sfo_sfo_ff</span>,</span></span> -<span class="r-in"><span> <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">m_dfop_sfo</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">ds_2</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nlme.mmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># With formation fractions this does not coverge with defaults</span></span></span> -<span class="r-in"><span> <span class="co"># f_nlme_sfo_sfo_ff <- nlme(f_2["SFO-SFO-ff", ])</span></span></span> -<span class="r-in"><span> <span class="co">#plot(f_nlme_sfo_sfo_ff)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># For the following, we need to increase pnlsMaxIter and the tolerance</span></span></span> -<span class="r-in"><span> <span class="co"># to get convergence</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>,</span></span> -<span class="r-in"><span> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">5e-4</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="nlme.mmkin-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span>, <span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio p-value</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274 </span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_sfo_sfo 2 9 1085.1821 1113.4043 -533.5910 1 vs 2 249.3274 <.0001</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink parent_A1 A1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 0.5912432 0.4087568 1.0000000 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 19.13518 63.5657</span> -<span class="r-out co"><span class="r-pr">#></span> A1 66.02155 219.3189</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_A1 parent_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 0.2768575 0.7231425 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 11.07091 104.6320 31.49737 4.462384 46.20825</span> -<span class="r-out co"><span class="r-pr">#></span> A1 162.30507 539.1658 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="fu">findFunction</span><span class="op">(</span><span class="st">"varConstProp"</span><span class="op">)</span><span class="op">)</span> <span class="op">></span> <span class="fl">0</span><span class="op">)</span> <span class="op">{</span> <span class="co"># tc error model for nlme available</span></span></span> -<span class="r-in"><span> <span class="co"># Attempts to fit metabolite kinetics with the tc error model are possible,</span></span></span> -<span class="r-in"><span> <span class="co"># but need tweeking of control values and sometimes do not converge</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_sfo_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_tc</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_dfop_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_tc</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nlme_sfo</span>, <span class="va">f_nlme_sfo_tc</span>, <span class="va">f_nlme_dfop</span>, <span class="va">f_nlme_dfop_tc</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_dfop_tc</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="op">}</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -238.4</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> -<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1) </span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis </span> -<span class="r-out co"><span class="r-pr">#></span> 94.04773 -1.82340 -4.16716 0.05686 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k1 ~ 1, log_k2 ~ 1, g_qlogis ~ 1)</span> -<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k1 log_k2 g_qlogis Residual</span> -<span class="r-out co"><span class="r-pr">#></span> StdDev: 2.474 0.85 1.337 0.4659 1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Constant plus proportion of variance covariate</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: ~fitted(.) </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> -<span class="r-out co"><span class="r-pr">#></span> const prop </span> -<span class="r-out co"><span class="r-pr">#></span> 2.23223593 0.01262367 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_2_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_2</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_nlme_sfo_sfo_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2_obs</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_nlme_sfo_sfo_obs</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by maximum likelihood</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent_sink * parent - k_parent_A1 * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + k_parent_A1 * parent - k_A1_sink * A1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Log-likelihood: -473</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> -<span class="r-out co"><span class="r-pr">#></span> list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1) </span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 87.976 -3.670 -4.164 -4.645 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent_sink ~ 1, log_k_parent_A1 ~ 1, log_k_A1_sink ~ 1)</span> -<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_A1 log_k_A1_sink Residual</span> -<span class="r-out co"><span class="r-pr">#></span> StdDev: 3.992 1.777 1.055 0.4821 6.483</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Different standard deviations per stratum</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: ~1 | name </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> -<span class="r-out co"><span class="r-pr">#></span> parent A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 1.0000000 0.2049994 </span> -<span class="r-in"><span> <span class="va">f_nlme_dfop_sfo_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_2_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>,</span></span> -<span class="r-in"><span> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">5e-4</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_2_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_2</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="co"># f_nlme_sfo_sfo_tc <- nlme(f_2_tc["SFO-SFO", ]) # No convergence with 50 iterations</span></span></span> -<span class="r-in"><span> <span class="co"># f_nlme_dfop_sfo_tc <- nlme(f_2_tc["DFOP-SFO", ],</span></span></span> -<span class="r-in"><span> <span class="co"># control = list(pnlsMaxIter = 120, tolerance = 5e-4)) # Error in X[, fmap[[nm]]] <- gradnm</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_nlme_dfop_sfo</span>, <span class="va">f_nlme_dfop_sfo_obs</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Model df AIC BIC logLik Test L.Ratio</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo 1 13 843.8547 884.6201 -408.9274 </span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo_obs 2 14 817.5338 861.4350 -394.7669 1 vs 2 28.32093</span> -<span class="r-out co"><span class="r-pr">#></span> p-value</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo </span> -<span class="r-out co"><span class="r-pr">#></span> f_nlme_dfop_sfo_obs <.0001</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 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objects using the Stochastic Approximation -Expectation Maximisation algorithm (SAEM) or First Order Conditional -Estimation with Interaction (FOCEI).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for mmkin</span> -<span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span> - <span class="va">object</span>, - data <span class="op">=</span> <span class="cn">NULL</span>, - est <span class="op">=</span> <span class="cn">NULL</span>, - control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="op">)</span>, - table <span class="op">=</span> <span class="fu">tableControl</span><span class="op">(</span><span class="op">)</span>, - error_model <span class="op">=</span> <span class="va">object</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">err_mod</span>, - test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>, - conf.level <span class="op">=</span> <span class="fl">0.6</span>, - degparms_start <span class="op">=</span> <span class="st">"auto"</span>, - eta_start <span class="op">=</span> <span class="st">"auto"</span>, - <span class="va">...</span>, - save <span class="op">=</span> <span class="cn">NULL</span>, - envir <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/sys.parent.html" class="external-link">parent.frame</a></span><span class="op">(</span><span class="op">)</span> -<span class="op">)</span> - -<span class="co"># S3 method for nlmixr.mmkin</span> -<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span> - -<span class="fu">nlmixr_model</span><span class="op">(</span> - <span class="va">object</span>, - est <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"saem"</span>, <span class="st">"focei"</span><span class="op">)</span>, - degparms_start <span class="op">=</span> <span class="st">"auto"</span>, - eta_start <span class="op">=</span> <span class="st">"auto"</span>, - test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>, - conf.level <span class="op">=</span> <span class="fl">0.6</span>, - error_model <span class="op">=</span> <span class="va">object</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">err_mod</span>, - add_attributes <span class="op">=</span> <span class="cn">FALSE</span> -<span class="op">)</span> - -<span class="fu">nlmixr_data</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <a href="mmkin.html">mmkin</a> row object containing several fits of the same -<a href="mkinmod.html">mkinmod</a> model to different datasets</p></dd> -<dt>data</dt> -<dd><p>Not used, as the data are extracted from the mmkin row object</p></dd> -<dt>est</dt> -<dd><p>Estimation method passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> -<dt>control</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> -<dt>table</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> -<dt>error_model</dt> -<dd><p>Optional argument to override the error model which is -being set based on the error model used in the mmkin row object.</p></dd> -<dt>test_log_parms</dt> -<dd><p>If TRUE, an attempt is made to use more robust starting -values for population parameters fitted as log parameters in mkin (like -rate constants) by only considering rate constants that pass the t-test -when calculating mean degradation parameters using <a href="mean_degparms.html">mean_degparms</a>.</p></dd> -<dt>conf.level</dt> -<dd><p>Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.</p></dd> -<dt>degparms_start</dt> -<dd><p>Parameter values given as a named numeric vector will -be used to override the starting values obtained from the 'mmkin' object.</p></dd> -<dt>eta_start</dt> -<dd><p>Standard deviations on the transformed scale given as a -named numeric vector will be used to override the starting values obtained -from the 'mmkin' object.</p></dd> -<dt>...</dt> -<dd><p>Passed to nlmixr_model</p></dd> -<dt>save</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> -<dt>envir</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p></dd> -<dt>x</dt> -<dd><p>An nlmixr.mmkin object to print</p></dd> -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> -<dt>add_attributes</dt> -<dd><p>Should the starting values used for degradation model -parameters and their distribution and for the error model parameters -be returned as attributes?</p></dd> -</dl></div> - <div id="value"> - <h2>Value</h2> - <p>An S3 object of class 'nlmixr.mmkin', containing the fitted -<a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a> object as a list component named 'nm'. The -object also inherits from 'mixed.mmkin'. -An function defining a model suitable for fitting with <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a>. -An dataframe suitable for use with <a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr::nlmixr</a></p> - </div> - <div id="details"> - <h2>Details</h2> - <p>An mmkin row object is essentially a list of mkinfit objects that have been -obtained by fitting the same model to a list of datasets using <a href="mkinfit.html">mkinfit</a>.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="summary.nlmixr.mmkin.html">summary.nlmixr.mmkin</a> <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># \dontrun{</span></span> -<span class="r-in"><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span> -<span class="r-in"> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_mmkin_parent</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span>, <span class="st">"HS"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_mmkin_parent_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>,</span> -<span class="r-in"> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/nlmixrdevelopment/nlmixr" class="external-link">nlmixr</a></span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Attaching package: ‘nlmixr’</span> -<span class="r-msg co"><span class="r-pr">#></span> The following object is masked from ‘package:mkin’:</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> saem</span> -<span class="r-in"><span class="va">f_nlmixr_sfo_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> RxODE 1.1.4 using 8 threads (see ?getRxThreads)</span> -<span class="r-msg co"><span class="r-pr">#></span> no cache: create with `rxCreateCache()`</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_sfo_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_nlmixr_fomc_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_fomc_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_nlmixr_dfop_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_nlmixr_hs_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_hs_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_nlmixr_fomc_saem_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/saemControl.html" class="external-link">saemControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_fomc_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/foceiControl.html" class="external-link">foceiControl</a></span><span class="op">(</span>print <span class="op">=</span> <span class="fl">0</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="va">f_nlmixr_sfo_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_sfo_focei</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_fomc_focei</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_dfop_focei</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_hs_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_hs_focei</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_saem_tc</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_fomc_focei_tc</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_saem$nm 5 624.9492</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_focei$nm 5 625.0695</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_saem$nm 7 463.7577</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_focei$nm 7 468.0861</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_saem$nm 9 495.1980</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_focei$nm 9 495.1072</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_hs_saem$nm 9 531.0689</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_hs_focei$nm 9 545.6728</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_saem_tc$nm 8 462.1411</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_focei_tc$nm 8 470.0745</span> -<span class="r-in"></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 468.0781</span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"HS"</span>, <span class="op">]</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 535.609</span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># The FOCEI fit of FOMC with constant variance or the tc error model is best</span></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_saem_tc</span><span class="op">)</span></span> -<span class="r-plt img"><img src="nlmixr.mmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> -<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-in"><span class="va">fomc_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> -<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span> -<span class="r-in"> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">f_mmkin_const</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"const"</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_mmkin_obs</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_mmkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="fu">nlmixr_model</span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> Constant variance for more than one variable is not supported for est = 'saem'</span> -<span class="r-msg co"><span class="r-pr">#></span> Changing the error model to 'obs' (variance by observed variable)</span> -<span class="r-out co"><span class="r-pr">#></span> function () </span> -<span class="r-out co"><span class="r-pr">#></span> {</span> -<span class="r-out co"><span class="r-pr">#></span> ini({</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 = 87</span> -<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 ~ 4.2</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent = -3.2</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_k_parent ~ 1.5</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 = -4.6</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 ~ 0.56</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis = -0.33</span> -<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis ~ 1.1</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_parent = 4.3</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_A1 = 4.3</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> model({</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0_model = parent_0 + eta.parent_0</span> -<span class="r-out co"><span class="r-pr">#></span> parent(0) = parent_0_model</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent = exp(log_k_parent + eta.log_k_parent)</span> -<span class="r-out co"><span class="r-pr">#></span> k_A1 = exp(log_k_A1 + eta.log_k_A1)</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_A1 = expit(f_parent_qlogis + eta.f_parent_qlogis)</span> -<span class="r-out co"><span class="r-pr">#></span> d/dt(parent) = -k_parent * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d/dt(A1) = +f_parent_to_A1 * k_parent * parent - k_A1 * </span> -<span class="r-out co"><span class="r-pr">#></span> A1</span> -<span class="r-out co"><span class="r-pr">#></span> parent ~ add(sigma_parent)</span> -<span class="r-out co"><span class="r-pr">#></span> A1 ~ add(sigma_A1)</span> -<span class="r-out co"><span class="r-pr">#></span> })</span> -<span class="r-out co"><span class="r-pr">#></span> }</span> -<span class="r-out co"><span class="r-pr">#></span> <environment: 0x55556c775068></span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># A single constant variance is currently only possible with est = 'focei' in nlmixr</span></span> -<span class="r-in"><span class="va">f_nlmixr_sfo_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 |log_k_parent | log_k_A1 |f_parent_qlogis |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| sigma | o1 | o2 | o3 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o4 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 756.61847 | 1.000 | -0.9694 | -1.000 | -0.9068 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8057 | -0.8843 | -0.8798 | -0.8743 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8782 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 756.61847 | 87.00 | -3.200 | -4.600 | -0.3300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.300 | 0.6985 | 0.9036 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9765 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 756.61847</span> | 87.00 | 0.04076 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.300 | 0.6985 | 0.9036 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9765 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 104.1 | 0.02915 | 0.3320 | 0.4427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -29.46 | 6.499 | 3.260 | -8.158 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.501 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 4014.8405 | 0.04387 | -0.9697 | -1.003 | -0.9108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5352 | -0.9440 | -0.9098 | -0.7994 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8277 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 4014.8405 | 3.817 | -3.200 | -4.603 | -0.3313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.882 | 0.6569 | 0.8766 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.026 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 4014.8405</span> | 3.817 | 0.04075 | 0.01002 | 0.4179 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.882 | 0.6569 | 0.8766 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.026 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 784.09766 | 0.9044 | -0.9695 | -1.000 | -0.9072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.8903 | -0.8828 | -0.8668 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8732 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 784.09766 | 78.68 | -3.200 | -4.600 | -0.3301 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.358 | 0.6944 | 0.9009 | 1.165 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9814 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 784.09766</span> | 78.68 | 0.04076 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.358 | 0.6944 | 0.9009 | 1.165 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9814 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 755.85897 | 0.9864 | -0.9694 | -1.000 | -0.9068 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8018 | -0.8852 | -0.8803 | -0.8733 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8775 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 755.85897 | 85.82 | -3.200 | -4.600 | -0.3300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.308 | 0.6979 | 0.9032 | 1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9772 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.85897</span> | 85.82 | 0.04076 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.308 | 0.6979 | 0.9032 | 1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9772 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.67 | 0.1182 | 0.2197 | 0.3686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -28.82 | 3.860 | 3.200 | -8.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.254 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 755.50135 | 0.9911 | -0.9695 | -1.000 | -0.9070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7893 | -0.8868 | -0.8816 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8752 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 755.50135 | 86.22 | -3.200 | -4.600 | -0.3301 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.335 | 0.6968 | 0.9020 | 1.161 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9794 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.50135</span> | 86.22 | 0.04076 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.335 | 0.6968 | 0.9020 | 1.161 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9794 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 755.34910 | 0.9966 | -0.9695 | -1.000 | -0.9072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7744 | -0.8888 | -0.8833 | -0.8654 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8725 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 755.3491 | 86.70 | -3.200 | -4.600 | -0.3301 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.367 | 0.6954 | 0.9005 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9820 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 755.3491</span> | 86.70 | 0.04076 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.367 | 0.6954 | 0.9005 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9820 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 73.92 | 0.04965 | 0.3063 | 0.4373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -23.46 | 5.143 | 2.934 | -7.746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.165 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 754.44379 | 0.9831 | -0.9697 | -1.001 | -0.9076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7489 | -0.8930 | -0.8865 | -0.8566 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8669 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 754.44379 | 85.53 | -3.200 | -4.601 | -0.3303 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.422 | 0.6925 | 0.8975 | 1.176 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9875 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 754.44379</span> | 85.53 | 0.04075 | 0.01005 | 0.4182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.422 | 0.6925 | 0.8975 | 1.176 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9875 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.39 | 0.1354 | 0.1953 | 0.3724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -19.20 | 3.020 | 2.621 | -7.506 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.671 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 753.82350 | 0.9908 | -0.9699 | -1.001 | -0.9085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7249 | -0.8992 | -0.8910 | -0.8427 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8580 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 753.8235 | 86.20 | -3.200 | -4.601 | -0.3306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.474 | 0.6881 | 0.8935 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9962 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.8235</span> | 86.20 | 0.04074 | 0.01004 | 0.4181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.474 | 0.6881 | 0.8935 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.9962 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 25.33 | 0.08213 | 0.2542 | 0.4339 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -14.89 | 3.322 | 2.230 | -6.934 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.324 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 753.42397 | 0.9836 | -0.9702 | -1.002 | -0.9101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7094 | -0.9058 | -0.8962 | -0.8215 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8457 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 753.42397 | 85.57 | -3.201 | -4.602 | -0.3311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.507 | 0.6835 | 0.8888 | 1.217 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.008 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.42397</span> | 85.57 | 0.04073 | 0.01003 | 0.4180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.507 | 0.6835 | 0.8888 | 1.217 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.008 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.38 | 0.1220 | 0.1752 | 0.4111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -12.58 | 2.402 | 1.769 | -6.044 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.541 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 753.10125 | 0.9902 | -0.9707 | -1.003 | -0.9128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7033 | -0.9147 | -0.8999 | -0.7966 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8328 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 753.10125 | 86.15 | -3.201 | -4.603 | -0.3320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.520 | 0.6773 | 0.8855 | 1.246 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.021 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 753.10125</span> | 86.15 | 0.04071 | 0.01002 | 0.4178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.520 | 0.6773 | 0.8855 | 1.246 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.021 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.19 | 0.07644 | 0.2005 | 0.4693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -11.34 | 2.660 | 1.470 | -4.866 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.908 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 752.83558 | 0.9856 | -0.9716 | -1.004 | -0.9194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6931 | -0.9294 | -0.8999 | -0.7740 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8246 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.83558 | 85.75 | -3.202 | -4.604 | -0.3342 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.542 | 0.6671 | 0.8855 | 1.272 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.029 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.83558</span> | 85.75 | 0.04067 | 0.01001 | 0.4172 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.542 | 0.6671 | 0.8855 | 1.272 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.029 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.42 | 0.09700 | 0.1175 | 0.4453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -9.793 | 1.829 | 1.489 | -3.997 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.337 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 752.64046 | 0.9898 | -0.9731 | -1.005 | -0.9331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6718 | -0.9413 | -0.9101 | -0.7759 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8318 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.64046 | 86.12 | -3.204 | -4.605 | -0.3387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.588 | 0.6587 | 0.8763 | 1.270 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.022 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.64046</span> | 86.12 | 0.04061 | 0.01000 | 0.4161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.588 | 0.6587 | 0.8763 | 1.270 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.022 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.96 | 0.06018 | 0.1556 | 0.4415 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -6.445 | 1.822 | 0.6282 | -4.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.761 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 752.52461 | 0.9874 | -0.9741 | -1.006 | -0.9430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6755 | -0.9483 | -0.9069 | -0.7553 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8127 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.52461 | 85.90 | -3.205 | -4.606 | -0.3420 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.580 | 0.6538 | 0.8792 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.52461</span> | 85.90 | 0.04057 | 0.009996 | 0.4153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.580 | 0.6538 | 0.8792 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.319 | 0.06758 | 0.1323 | 0.4528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -7.018 | 1.348 | 0.9128 | -3.312 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.706 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 752.47650 | 0.9920 | -0.9750 | -1.008 | -0.9578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6735 | -0.9481 | -0.9014 | -0.7293 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8100 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.4765 | 86.30 | -3.206 | -4.608 | -0.3468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.584 | 0.6539 | 0.8841 | 1.324 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.043 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.4765</span> | 86.30 | 0.04054 | 0.009974 | 0.4142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.584 | 0.6539 | 0.8841 | 1.324 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.043 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.38 | 0.03719 | 0.08701 | 0.4621 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -6.642 | 1.808 | 1.401 | -2.463 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.595 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 752.37074 | 0.9880 | -0.9759 | -1.009 | -0.9778 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6665 | -0.9465 | -0.9156 | -0.7192 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8239 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.37074 | 85.96 | -3.206 | -4.609 | -0.3534 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.599 | 0.6551 | 0.8713 | 1.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.030 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.37074</span> | 85.96 | 0.04050 | 0.009963 | 0.4125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.599 | 0.6551 | 0.8713 | 1.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.030 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8866 | 0.05090 | -0.01541 | 0.3812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.712 | 1.436 | 0.1646 | -2.191 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.247 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 752.26949 | 0.9921 | -0.9761 | -1.009 | -0.9796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6402 | -0.9531 | -0.9164 | -0.7091 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8135 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.26949 | 86.31 | -3.207 | -4.609 | -0.3540 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6505 | 0.8706 | 1.347 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.26949</span> | 86.31 | 0.04049 | 0.009963 | 0.4124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6505 | 0.8706 | 1.347 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.040 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.82 | 0.02710 | 0.03892 | 0.4267 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.005 | 1.500 | 0.1022 | -1.862 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.773 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 752.20271 | 0.9873 | -0.9768 | -1.006 | -0.9927 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6361 | -0.9677 | -0.9007 | -0.7162 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7982 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.20271 | 85.89 | -3.207 | -4.606 | -0.3584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.664 | 0.6403 | 0.8848 | 1.339 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.055 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.20271</span> | 85.89 | 0.04046 | 0.009992 | 0.4114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.664 | 0.6403 | 0.8848 | 1.339 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.055 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.259 | 0.05081 | 0.1320 | 0.4166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.497 | 0.4663 | 1.471 | -1.984 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9590 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 752.16826 | 0.9883 | -0.9778 | -1.006 | -1.005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6437 | -0.9795 | -0.9210 | -0.7076 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.16826 | 85.98 | -3.208 | -4.606 | -0.3626 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.648 | 0.6320 | 0.8664 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.16826</span> | 85.98 | 0.04042 | 0.009989 | 0.4103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.648 | 0.6320 | 0.8664 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.732 | 0.03428 | 0.1666 | 0.4265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.413 | 0.2526 | -0.2557 | -1.689 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3553 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 752.25223 | 0.9952 | -0.9788 | -1.010 | -1.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6370 | -0.9826 | -0.9156 | -0.6853 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7912 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.25223 | 86.58 | -3.209 | -4.610 | -0.3684 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.663 | 0.6299 | 0.8713 | 1.374 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.25223</span> | 86.58 | 0.04038 | 0.009949 | 0.4089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.663 | 0.6299 | 0.8713 | 1.374 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 752.18605 | 0.9920 | -0.9778 | -1.007 | -1.006 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6387 | -0.9801 | -0.9204 | -0.7040 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7866 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.18605 | 86.30 | -3.208 | -4.607 | -0.3629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8669 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.18605</span> | 86.30 | 0.04042 | 0.009985 | 0.4103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8669 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 752.16428 | 0.9894 | -0.9778 | -1.006 | -1.006 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6422 | -0.9797 | -0.9208 | -0.7065 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7871 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.16428 | 86.08 | -3.208 | -4.606 | -0.3627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.651 | 0.6319 | 0.8666 | 1.350 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.16428</span> | 86.08 | 0.04042 | 0.009988 | 0.4103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.651 | 0.6319 | 0.8666 | 1.350 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.144 | 0.02886 | 0.1726 | 0.4333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.192 | 0.3285 | -0.2407 | -1.661 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3568 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 752.15919 | 0.9884 | -0.9779 | -1.007 | -1.007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6420 | -0.9798 | -0.9206 | -0.7051 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7874 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.15919 | 85.99 | -3.208 | -4.607 | -0.3630 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.652 | 0.6319 | 0.8668 | 1.352 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15919</span> | 85.99 | 0.04042 | 0.009985 | 0.4102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.652 | 0.6319 | 0.8668 | 1.352 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.486 | 0.03361 | 0.1549 | 0.4244 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.177 | 0.2364 | -0.2213 | -1.616 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3570 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 752.15545 | 0.9894 | -0.9779 | -1.007 | -1.007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6405 | -0.9799 | -0.9204 | -0.7040 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.15545 | 86.07 | -3.208 | -4.607 | -0.3631 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.655 | 0.6318 | 0.8669 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15545</span> | 86.07 | 0.04042 | 0.009984 | 0.4102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.655 | 0.6318 | 0.8669 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.936 | 0.02854 | 0.1600 | 0.4306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.962 | 0.3065 | -0.2063 | -1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3570 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 752.15077 | 0.9884 | -0.9779 | -1.007 | -1.008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6403 | -0.9800 | -0.9202 | -0.7026 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7875 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.15077 | 85.99 | -3.209 | -4.607 | -0.3635 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6317 | 0.8672 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.15077</span> | 85.99 | 0.04042 | 0.009981 | 0.4101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.656 | 0.6317 | 0.8672 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.303 | 0.03292 | 0.1430 | 0.4220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.955 | 0.2207 | -0.1874 | -1.542 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3581 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 752.14731 | 0.9893 | -0.9780 | -1.007 | -1.009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6389 | -0.9801 | -0.9200 | -0.7014 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.14731 | 86.07 | -3.209 | -4.607 | -0.3637 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8673 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.14731</span> | 86.07 | 0.04042 | 0.009980 | 0.4101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8673 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.764 | 0.02806 | 0.1473 | 0.4277 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.749 | 0.2865 | -0.1727 | -1.510 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3572 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 752.14299 | 0.9884 | -0.9780 | -1.007 | -1.010 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6388 | -0.9801 | -0.9198 | -0.7000 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.14299 | 85.99 | -3.209 | -4.607 | -0.3641 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8675 | 1.358 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.14299</span> | 85.99 | 0.04041 | 0.009978 | 0.4100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.659 | 0.6316 | 0.8675 | 1.358 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.130 | 0.03192 | 0.1311 | 0.4194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.750 | 0.2064 | -0.1542 | -1.466 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3587 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 752.13982 | 0.9893 | -0.9781 | -1.008 | -1.010 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6374 | -0.9803 | -0.9196 | -0.6987 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.13982 | 86.07 | -3.209 | -4.608 | -0.3642 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8676 | 1.359 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.13982</span> | 86.07 | 0.04041 | 0.009977 | 0.4099 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8676 | 1.359 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.635 | 0.02760 | 0.1350 | 0.4248 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.550 | 0.2683 | -0.1407 | -1.433 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3557 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 752.13580 | 0.9884 | -0.9782 | -1.008 | -1.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6373 | -0.9803 | -0.9194 | -0.6973 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.1358 | 85.99 | -3.209 | -4.608 | -0.3647 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8678 | 1.361 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.1358</span> | 85.99 | 0.04041 | 0.009975 | 0.4098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.662 | 0.6315 | 0.8678 | 1.361 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.9657 | 0.03147 | 0.1207 | 0.4166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.557 | 0.1931 | -0.1227 | -1.391 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3574 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 752.13295 | 0.9893 | -0.9782 | -1.008 | -1.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6359 | -0.9805 | -0.9193 | -0.6961 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7873 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.13295 | 86.07 | -3.209 | -4.608 | -0.3648 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8679 | 1.362 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.13295</span> | 86.07 | 0.04041 | 0.009973 | 0.4098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8679 | 1.362 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.554 | 0.02702 | 0.1245 | 0.4220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.357 | 0.2511 | -0.1114 | -1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3512 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 752.12919 | 0.9885 | -0.9783 | -1.008 | -1.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6359 | -0.9804 | -0.9191 | -0.6947 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7876 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.12919 | 86.00 | -3.209 | -4.608 | -0.3653 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8681 | 1.364 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12919</span> | 86.00 | 0.04040 | 0.009972 | 0.4097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.665 | 0.6314 | 0.8681 | 1.364 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8077 | 0.03076 | 0.1104 | 0.4140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.370 | 0.1799 | -0.09417 | -1.307 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3529 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 752.12656 | 0.9893 | -0.9783 | -1.008 | -1.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6345 | -0.9806 | -0.9190 | -0.6934 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.12656 | 86.07 | -3.209 | -4.608 | -0.3654 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8682 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12656</span> | 86.07 | 0.04040 | 0.009970 | 0.4096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8682 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.375 | 0.02651 | 0.1140 | 0.4191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.173 | 0.2330 | -0.08481 | -1.281 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3435 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 752.12310 | 0.9885 | -0.9784 | -1.008 | -1.016 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6345 | -0.9806 | -0.9188 | -0.6922 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7875 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.1231 | 86.00 | -3.209 | -4.608 | -0.3659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8684 | 1.367 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.1231</span> | 86.00 | 0.04040 | 0.009969 | 0.4095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.668 | 0.6313 | 0.8684 | 1.367 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.6515 | 0.02994 | 0.1012 | 0.4113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.192 | 0.1669 | -0.06829 | -1.233 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3455 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 752.12055 | 0.9892 | -0.9784 | -1.008 | -1.016 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6332 | -0.9808 | -0.9187 | -0.6908 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7871 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.12055 | 86.06 | -3.209 | -4.608 | -0.3661 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8685 | 1.368 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.12055</span> | 86.06 | 0.04040 | 0.009968 | 0.4095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8685 | 1.368 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.998 | 0.02610 | 0.1041 | 0.4159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | 0.2127 | -0.06061 | -1.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3333 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 752.11747 | 0.9885 | -0.9785 | -1.009 | -1.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6332 | -0.9807 | -0.9185 | -0.6896 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7874 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.11747 | 86.00 | -3.209 | -4.609 | -0.3666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8687 | 1.370 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11747</span> | 86.00 | 0.04039 | 0.009966 | 0.4094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.671 | 0.6312 | 0.8687 | 1.370 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5772 | 0.02918 | 0.09258 | 0.4085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | 0.1535 | -0.04467 | -1.159 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3360 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 752.11522 | 0.9892 | -0.9785 | -1.009 | -1.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6319 | -0.9809 | -0.9185 | -0.6881 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7870 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.11522 | 86.06 | -3.209 | -4.609 | -0.3668 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.674 | 0.6311 | 0.8687 | 1.371 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11522</span> | 86.06 | 0.04039 | 0.009965 | 0.4093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.674 | 0.6311 | 0.8687 | 1.371 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.959 | 0.02535 | 0.09612 | 0.4130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8451 | 0.1980 | -0.03883 | -1.121 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3219 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 752.11234 | 0.9885 | -0.9786 | -1.009 | -1.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6320 | -0.9808 | -0.9183 | -0.6870 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7872 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.11234 | 86.00 | -3.209 | -4.609 | -0.3673 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | 0.6311 | 0.8689 | 1.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11234</span> | 86.00 | 0.04039 | 0.009964 | 0.4092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | 0.6311 | 0.8689 | 1.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.065 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5042 | 0.02791 | 0.08363 | 0.4056 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8741 | 0.1402 | -0.02542 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3257 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 752.11033 | 0.9892 | -0.9787 | -1.009 | -1.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6308 | -0.9810 | -0.9182 | -0.6855 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7868 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.11033 | 86.06 | -3.209 | -4.609 | -0.3675 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8689 | 1.374 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.11033</span> | 86.06 | 0.04039 | 0.009963 | 0.4091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8689 | 1.374 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.874 | 0.02465 | 0.08719 | 0.4100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7032 | 0.1835 | -0.01978 | -1.047 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3084 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 752.10764 | 0.9885 | -0.9787 | -1.009 | -1.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6309 | -0.9810 | -0.9181 | -0.6844 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7870 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.10764 | 86.00 | -3.209 | -4.609 | -0.3681 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8691 | 1.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10764</span> | 86.00 | 0.04038 | 0.009962 | 0.4090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.676 | 0.6310 | 0.8691 | 1.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4131 | 0.02699 | 0.07721 | 0.4026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7354 | 0.1282 | -0.007503 | -1.011 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3125 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 752.10572 | 0.9892 | -0.9788 | -1.009 | -1.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6298 | -0.9812 | -0.9181 | -0.6829 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7865 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.10572 | 86.06 | -3.209 | -4.609 | -0.3683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8691 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10572</span> | 86.06 | 0.04038 | 0.009960 | 0.4090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8691 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.580 | 0.02411 | 0.07834 | 0.4067 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5755 | 0.1666 | -0.003596 | -0.9604 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2924 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 752.10333 | 0.9885 | -0.9789 | -1.009 | -1.024 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6300 | -0.9811 | -0.9179 | -0.6819 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7867 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.10333 | 86.00 | -3.209 | -4.609 | -0.3688 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8692 | 1.378 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10333</span> | 86.00 | 0.04038 | 0.009959 | 0.4088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.678 | 0.6309 | 0.8692 | 1.378 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3772 | 0.02648 | 0.06875 | 0.3997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6082 | 0.1162 | 0.008208 | -0.9328 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2962 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 752.10169 | 0.9892 | -0.9789 | -1.009 | -1.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6289 | -0.9813 | -0.9179 | -0.6803 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7862 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.10169 | 86.06 | -3.209 | -4.609 | -0.3691 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8692 | 1.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.10169</span> | 86.06 | 0.04038 | 0.009958 | 0.4088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8692 | 1.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.644 | 0.02338 | 0.07127 | 0.4037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4618 | 0.1554 | 0.009391 | -0.8908 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2755 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 752.09938 | 0.9886 | -0.9790 | -1.009 | -1.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6291 | -0.9812 | -0.9178 | -0.6794 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7864 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.09938 | 86.00 | -3.210 | -4.609 | -0.3697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8693 | 1.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09938</span> | 86.00 | 0.04037 | 0.009958 | 0.4086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.680 | 0.6308 | 0.8693 | 1.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2627 | 0.02548 | 0.06256 | 0.3967 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4955 | 0.1055 | 0.02027 | -0.8653 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2789 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 752.09757 | 0.9890 | -0.9791 | -1.010 | -1.028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6281 | -0.9814 | -0.9178 | -0.6778 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7859 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.09757 | 86.05 | -3.210 | -4.610 | -0.3699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.682 | 0.6307 | 0.8693 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09757</span> | 86.05 | 0.04037 | 0.009956 | 0.4086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.682 | 0.6307 | 0.8693 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.867 | 0.02296 | 0.06369 | 0.3997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3645 | 0.1327 | 0.01894 | -0.8216 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2549 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 752.09570 | 0.9886 | -0.9791 | -1.010 | -1.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6283 | -0.9814 | -0.9177 | -0.6770 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7861 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.0957 | 86.00 | -3.210 | -4.610 | -0.3705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.681 | 0.6307 | 0.8694 | 1.384 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.0957</span> | 86.00 | 0.04037 | 0.009956 | 0.4084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.681 | 0.6307 | 0.8694 | 1.384 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.066 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2846 | 0.02474 | 0.05675 | 0.3935 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3960 | 0.09353 | 0.02976 | -0.7961 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2595 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 752.09434 | 0.9891 | -0.9792 | -1.010 | -1.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6275 | -0.9816 | -0.9177 | -0.6754 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7856 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.09434 | 86.05 | -3.210 | -4.610 | -0.3708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8694 | 1.386 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09434</span> | 86.05 | 0.04037 | 0.009955 | 0.4083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8694 | 1.386 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.348 | 0.02147 | 0.05816 | 0.3967 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2833 | 0.1286 | 0.02562 | -0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2380 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 752.09236 | 0.9886 | -0.9793 | -1.010 | -1.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6277 | -0.9815 | -0.9176 | -0.6746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7858 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.09236 | 86.01 | -3.210 | -4.610 | -0.3715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8695 | 1.387 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09236</span> | 86.01 | 0.04036 | 0.009954 | 0.4082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.683 | 0.6306 | 0.8695 | 1.387 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1856 | 0.02378 | 0.05144 | 0.3902 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3147 | 0.08386 | 0.03545 | -0.7433 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2408 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 752.09077 | 0.9890 | -0.9793 | -1.010 | -1.033 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6269 | -0.9817 | -0.9177 | -0.6729 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.09077 | 86.04 | -3.210 | -4.610 | -0.3717 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8694 | 1.389 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.09077</span> | 86.04 | 0.04036 | 0.009953 | 0.4081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8694 | 1.389 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 752.08937 | 0.9892 | -0.9795 | -1.010 | -1.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6267 | -0.9818 | -0.9176 | -0.6714 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.08937 | 86.06 | -3.210 | -4.610 | -0.3725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.685 | 0.6304 | 0.8695 | 1.391 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08937</span> | 86.06 | 0.04036 | 0.009952 | 0.4079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.685 | 0.6304 | 0.8695 | 1.391 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.945 | 0.01952 | 0.05064 | 0.3906 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1866 | 0.1233 | 0.03740 | -0.6554 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2138 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 752.08593 | 0.9886 | -0.9796 | -1.010 | -1.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6271 | -0.9817 | -0.9174 | -0.6701 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7856 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.08593 | 86.01 | -3.210 | -4.610 | -0.3740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8697 | 1.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08593</span> | 86.01 | 0.04035 | 0.009951 | 0.4076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.6305 | 0.8697 | 1.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.04707 | 0.02143 | 0.04311 | 0.3795 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2514 | 0.07631 | 0.05739 | -0.6184 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2313 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 752.08243 | 0.9889 | -0.9798 | -1.010 | -1.042 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6256 | -0.9821 | -0.9177 | -0.6665 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7842 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.08243 | 86.03 | -3.210 | -4.610 | -0.3748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6302 | 0.8694 | 1.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.08243</span> | 86.03 | 0.04034 | 0.009949 | 0.4074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6302 | 0.8694 | 1.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 752.07616 | 0.9895 | -0.9803 | -1.011 | -1.054 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6231 | -0.9827 | -0.9181 | -0.6582 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7817 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.07616 | 86.08 | -3.211 | -4.611 | -0.3786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.693 | 0.6298 | 0.8690 | 1.406 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.071 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.07616</span> | 86.08 | 0.04032 | 0.009942 | 0.4065 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.693 | 0.6298 | 0.8690 | 1.406 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.071 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.128 | 0.01286 | 0.03023 | 0.3726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2708 | 0.07184 | -0.02487 | -0.2959 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03882 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 752.06706 | 0.9888 | -0.9810 | -1.011 | -1.073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6241 | -0.9834 | -0.9174 | -0.6562 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7830 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.06706 | 86.03 | -3.212 | -4.611 | -0.3848 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.690 | 0.6293 | 0.8696 | 1.408 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.069 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.06706</span> | 86.03 | 0.04030 | 0.009938 | 0.4050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.690 | 0.6293 | 0.8696 | 1.408 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.069 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 752.05726 | 0.9892 | -0.9821 | -1.012 | -1.106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6257 | -0.9847 | -0.9162 | -0.6528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7853 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.05726 | 86.06 | -3.213 | -4.612 | -0.3958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6284 | 0.8707 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.05726</span> | 86.06 | 0.04025 | 0.009929 | 0.4023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.687 | 0.6284 | 0.8707 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.067 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 752.04392 | 0.9898 | -0.9854 | -1.015 | -1.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6305 | -0.9883 | -0.9128 | -0.6430 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7918 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.04392 | 86.11 | -3.216 | -4.615 | -0.4269 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.677 | 0.6259 | 0.8738 | 1.423 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.04392</span> | 86.11 | 0.04012 | 0.009906 | 0.3949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.677 | 0.6259 | 0.8738 | 1.423 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.061 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.566 | -0.02004 | 0.02472 | 0.1678 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6767 | -0.003606 | 0.4773 | 0.08205 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6933 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 752.05860 | 0.9880 | -0.9900 | -1.027 | -1.486 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6186 | -0.9338 | -0.9168 | -0.6653 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7443 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.0586 | 85.96 | -3.221 | -4.627 | -0.5212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.702 | 0.6640 | 0.8702 | 1.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.0586</span> | 85.96 | 0.03993 | 0.009780 | 0.3726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.702 | 0.6640 | 0.8702 | 1.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 752.02137 | 0.9885 | -0.9874 | -1.020 | -1.325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6252 | -0.9645 | -0.9146 | -0.6528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7710 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.02137 | 86.00 | -3.218 | -4.620 | -0.4681 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.02137</span> | 86.00 | 0.04004 | 0.009850 | 0.3851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.728 | -0.02729 | 0.08518 | 0.04185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2367 | 0.4063 | 0.2432 | 0.01436 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.07563 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 752.06656 | 0.9886 | -0.9792 | -1.053 | -1.433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6165 | -1.020 | -0.9133 | -0.6801 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7607 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.06656 | 86.01 | -3.210 | -4.653 | -0.5037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.707 | 0.6037 | 0.8734 | 1.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.06656</span> | 86.01 | 0.04036 | 0.009533 | 0.3767 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.707 | 0.6037 | 0.8734 | 1.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 752.02137 | 0.9885 | -0.9874 | -1.020 | -1.325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6252 | -0.9645 | -0.9146 | -0.6528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7710 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 752.02137 | 86.00 | -3.218 | -4.620 | -0.4681 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 752.02137</span> | 86.00 | 0.04004 | 0.009850 | 0.3851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.688 | 0.6425 | 0.8722 | 1.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.081 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta | sigma | o1 | o2 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o3 | o4 | o5 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 494.78160 | 1.000 | -1.000 | -0.9115 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.8592 | -0.8761 | -0.8740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8674 | -0.8694 | -0.8683 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.7816 | 94.00 | -5.400 | -1.000 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.600 | 0.7598 | 0.8633 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.189 | 1.089 | 1.146 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.7816</span> | 94.00 | 0.004517 | 0.2689 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.600 | 0.7598 | 0.8633 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.189 | 1.089 | 1.146 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -28.01 | 1.933 | -0.2086 | 0.01492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1687 | -59.79 | 10.74 | 9.966 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.82 | -8.862 | -10.52 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1353.4477 | 1.400 | -1.028 | -0.9085 | -0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.005584 | -1.029 | -1.016 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6987 | -0.7429 | -0.7181 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 1353.4477 | 131.6 | -5.428 | -0.9970 | -0.2002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.283 | 0.6433 | 0.7405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.390 | 1.227 | 1.318 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1353.4477</span> | 131.6 | 0.004394 | 0.2695 | 0.8186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 2.283 | 0.6433 | 0.7405 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.390 | 1.227 | 1.318 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 504.82409 | 1.040 | -1.003 | -0.9112 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7738 | -0.8914 | -0.8882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8506 | -0.8568 | -0.8533 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 504.82409 | 97.76 | -5.403 | -0.9997 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.668 | 0.7482 | 0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.209 | 1.103 | 1.163 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 504.82409</span> | 97.76 | 0.004504 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.668 | 0.7482 | 0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.209 | 1.103 | 1.163 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 494.10898 | 1.008 | -1.001 | -0.9114 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8416 | -0.8792 | -0.8769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8640 | -0.8668 | -0.8652 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.10898 | 94.77 | -5.401 | -0.9999 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.614 | 0.7574 | 0.8608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.193 | 1.092 | 1.149 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.10898</span> | 94.77 | 0.004514 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.614 | 0.7574 | 0.8608 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.193 | 1.092 | 1.149 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 147.0 | 1.955 | -0.08761 | 0.06834 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05948 | -55.61 | 11.89 | 8.304 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.01 | -8.510 | -10.24 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 492.58255 | 0.9992 | -1.001 | -0.9114 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8245 | -0.8825 | -0.8797 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8605 | -0.8643 | -0.8621 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 492.58255 | 93.93 | -5.401 | -0.9999 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.628 | 0.7550 | 0.8584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.197 | 1.095 | 1.153 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.58255</span> | 93.93 | 0.004511 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.628 | 0.7550 | 0.8584 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.197 | 1.095 | 1.153 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -43.22 | 1.882 | -0.2206 | -0.004719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1970 | -51.78 | 10.22 | 6.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.81 | -8.346 | -10.04 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 491.66702 | 1.006 | -1.002 | -0.9113 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.8063 | -0.8860 | -0.8822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8565 | -0.8614 | -0.8588 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.66702 | 94.52 | -5.402 | -0.9998 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.642 | 0.7523 | 0.8562 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.202 | 1.098 | 1.157 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.66702</span> | 94.52 | 0.004509 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.642 | 0.7523 | 0.8562 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.202 | 1.098 | 1.157 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 87.79 | 1.893 | -0.1269 | 0.04418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01699 | -47.85 | 10.34 | 7.758 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.67 | -8.213 | -9.916 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 490.57489 | 0.9987 | -1.002 | -0.9112 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7885 | -0.8895 | -0.8851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8525 | -0.8586 | -0.8553 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.57489 | 93.88 | -5.402 | -0.9998 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.657 | 0.7496 | 0.8537 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.207 | 1.101 | 1.161 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.57489</span> | 93.88 | 0.004506 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.657 | 0.7496 | 0.8537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.207 | 1.101 | 1.161 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -52.56 | 1.834 | -0.2285 | -0.01046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2159 | -44.44 | 9.379 | 7.248 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.47 | -8.044 | -9.710 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 489.67804 | 1.004 | -1.003 | -0.9112 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.7706 | -0.8932 | -0.8884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8482 | -0.8554 | -0.8516 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 489.67804 | 94.42 | -5.403 | -0.9997 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.671 | 0.7468 | 0.8509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.212 | 1.105 | 1.165 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.67804</span> | 94.42 | 0.004503 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.671 | 0.7468 | 0.8509 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.212 | 1.105 | 1.165 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 63.10 | 1.841 | -0.1396 | 0.03713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05177 | -40.65 | 9.345 | 6.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.29 | -7.879 | -9.567 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 488.80457 | 0.9984 | -1.004 | -0.9111 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.7529 | -0.8970 | -0.8913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8435 | -0.8521 | -0.8475 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.80457 | 93.85 | -5.404 | -0.9996 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.685 | 0.7439 | 0.8484 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.218 | 1.108 | 1.170 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.80457</span> | 93.85 | 0.004499 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.685 | 0.7439 | 0.8484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.218 | 1.108 | 1.170 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -56.52 | 1.788 | -0.2313 | -0.01570 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2287 | -37.43 | 8.740 | 5.512 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.08 | -7.680 | -9.353 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 487.98244 | 1.004 | -1.005 | -0.9110 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.7356 | -0.9012 | -0.8939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8380 | -0.8482 | -0.8428 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.98244 | 94.36 | -5.405 | -0.9995 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.699 | 0.7407 | 0.8461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.224 | 1.112 | 1.175 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.98244</span> | 94.36 | 0.004495 | 0.2690 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.169 | 1.699 | 0.7407 | 0.8461 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.224 | 1.112 | 1.175 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.57 | 1.794 | -0.1466 | 0.03517 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07178 | -34.12 | 8.494 | 6.684 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.82 | -7.482 | -9.140 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 487.23587 | 0.9987 | -1.006 | -0.9109 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.7192 | -0.9058 | -0.8980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8316 | -0.8438 | -0.8374 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.23587 | 93.88 | -5.406 | -0.9994 | -0.2001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.712 | 0.7372 | 0.8426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.232 | 1.117 | 1.181 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.23587</span> | 93.88 | 0.004490 | 0.2691 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.712 | 0.7372 | 0.8426 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.232 | 1.117 | 1.181 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.22 | 1.745 | -0.2274 | -0.009194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2301 | -31.48 | 7.992 | 6.132 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.64 | -7.269 | -8.903 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 486.53337 | 1.004 | -1.007 | -0.9107 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.7047 | -0.9109 | -0.9037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8240 | -0.8386 | -0.8310 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 486.53337 | 94.34 | -5.407 | -0.9993 | -0.2001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.724 | 0.7334 | 0.8376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.241 | 1.123 | 1.189 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.53337</span> | 94.34 | 0.004484 | 0.2691 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.724 | 0.7334 | 0.8376 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.241 | 1.123 | 1.189 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 43.47 | 1.742 | -0.1424 | 0.02918 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07089 | -28.76 | 7.629 | 4.806 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.24 | -6.953 | -8.584 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 485.91669 | 0.9989 | -1.009 | -0.9105 | -0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8484 | -0.6920 | -0.9165 | -0.9072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8145 | -0.8325 | -0.8231 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.91669 | 93.90 | -5.409 | -0.9991 | -0.2001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.734 | 0.7291 | 0.8346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.252 | 1.130 | 1.198 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.91669</span> | 93.90 | 0.004476 | 0.2691 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.734 | 0.7291 | 0.8346 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.252 | 1.130 | 1.198 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -44.30 | 1.699 | -0.2182 | 0.001936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2284 | -26.86 | 7.286 | 5.487 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.898 | -6.659 | -8.234 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 485.33976 | 1.003 | -1.011 | -0.9103 | -0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.6819 | -0.9228 | -0.9110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8035 | -0.8257 | -0.8143 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.33976 | 94.29 | -5.411 | -0.9988 | -0.2001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.742 | 0.7243 | 0.8314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.265 | 1.137 | 1.208 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.33976</span> | 94.29 | 0.004467 | 0.2692 | 0.8186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 1.742 | 0.7243 | 0.8314 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.265 | 1.137 | 1.208 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 484.77317 | 1.003 | -1.014 | -0.9100 | -0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8479 | -0.6718 | -0.9302 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7902 | -0.8175 | -0.8035 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.77317 | 94.32 | -5.414 | -0.9986 | -0.2002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.750 | 0.7187 | 0.8276 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.281 | 1.146 | 1.220 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.77317</span> | 94.32 | 0.004455 | 0.2692 | 0.8186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.176 | 1.750 | 0.7187 | 0.8276 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.281 | 1.146 | 1.220 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 483.17588 | 1.004 | -1.023 | -0.9091 | -0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.6384 | -0.9549 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7463 | -0.7903 | -0.7681 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.17588 | 94.41 | -5.423 | -0.9976 | -0.2004 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.777 | 0.6999 | 0.8153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.333 | 1.176 | 1.261 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.17588</span> | 94.41 | 0.004415 | 0.2694 | 0.8184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.777 | 0.6999 | 0.8153 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.333 | 1.176 | 1.261 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 481.21481 | 1.006 | -1.040 | -0.9072 | -0.8961 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8451 | -0.5721 | -1.004 | -0.9579 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6592 | -0.7365 | -0.6977 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.21481 | 94.58 | -5.440 | -0.9958 | -0.2008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.104 | 1.830 | 0.6628 | 0.7909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.437 | 1.234 | 1.341 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.21481</span> | 94.58 | 0.004338 | 0.2698 | 0.8181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.199 | 1.830 | 0.6628 | 0.7909 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.437 | 1.234 | 1.341 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 62.86 | 1.476 | 0.06730 | 0.05792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1123 | -8.977 | 1.055 | 2.914 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.044 | -1.094 | -2.299 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 481.29476 | 1.000 | -1.145 | -0.9129 | -0.8997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5378 | -0.8985 | -1.168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6228 | -0.8149 | -0.6969 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.29476 | 94.03 | -5.545 | -1.001 | -0.2043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.857 | 0.7428 | 0.6099 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.149 | 1.342 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.29476</span> | 94.03 | 0.003907 | 0.2687 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.857 | 0.7428 | 0.6099 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.149 | 1.342 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 480.77138 | 1.000 | -1.090 | -0.9099 | -0.8978 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.5555 | -0.9542 | -1.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6419 | -0.7733 | -0.6972 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.77138 | 94.01 | -5.490 | -0.9984 | -0.2025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.843 | 0.7004 | 0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.457 | 1.194 | 1.342 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.77138</span> | 94.01 | 0.004129 | 0.2693 | 0.8167 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 1.843 | 0.7004 | 0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.457 | 1.194 | 1.342 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -25.72 | 1.151 | 0.08772 | -0.007897 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07232 | -6.930 | 3.330 | -2.491 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.626 | -3.111 | -2.500 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 480.61717 | 1.001 | -1.203 | -0.9227 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5418 | -0.9405 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6281 | -0.7705 | -0.6908 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.61717 | 94.09 | -5.603 | -1.011 | -0.2049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.854 | 0.7108 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.197 | 1.349 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.61717</span> | 94.09 | 0.003688 | 0.2667 | 0.8147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.156 | 1.854 | 0.7108 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.197 | 1.349 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.61 | 0.9224 | -0.5881 | -0.06621 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1838 | -5.929 | 3.775 | 2.798 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.936 | -2.993 | -2.208 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 480.72130 | 1.009 | -1.314 | -0.9169 | -0.9003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5516 | -0.9873 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6340 | -0.7292 | -0.6819 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.7213 | 94.81 | -5.714 | -1.005 | -0.2049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.846 | 0.6753 | 0.7523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.467 | 1.242 | 1.359 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.7213</span> | 94.81 | 0.003299 | 0.2679 | 0.8147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.846 | 0.6753 | 0.7523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.467 | 1.242 | 1.359 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 480.86254 | 1.009 | -1.247 | -0.9202 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5429 | -0.9605 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6295 | -0.7530 | -0.6863 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.86254 | 94.84 | -5.647 | -1.009 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.853 | 0.6957 | 0.7520 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.472 | 1.216 | 1.354 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.86254</span> | 94.84 | 0.003530 | 0.2672 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.853 | 0.6957 | 0.7520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.472 | 1.216 | 1.354 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 480.98412 | 1.009 | -1.209 | -0.9220 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5381 | -0.9458 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6270 | -0.7661 | -0.6887 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.98412 | 94.85 | -5.609 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7069 | 0.7519 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.202 | 1.352 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.98412</span> | 94.85 | 0.003664 | 0.2669 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7069 | 0.7519 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.202 | 1.352 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 480.60990 | 1.003 | -1.203 | -0.9226 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5410 | -0.9411 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6278 | -0.7701 | -0.6905 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.6099 | 94.24 | -5.603 | -1.011 | -0.2049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.855 | 0.7104 | 0.7534 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.198 | 1.350 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.6099</span> | 94.24 | 0.003688 | 0.2668 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.156 | 1.855 | 0.7104 | 0.7534 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.198 | 1.350 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.29 | 0.9278 | -0.5289 | -0.04762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1043 | -5.468 | 3.876 | 0.6273 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.897 | -2.941 | -2.183 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 480.59557 | 1.001 | -1.204 | -0.9225 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8503 | -0.5407 | -0.9419 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6277 | -0.7694 | -0.6902 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.59557 | 94.13 | -5.604 | -1.011 | -0.2049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.855 | 0.7098 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.474 | 1.198 | 1.350 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.59557</span> | 94.13 | 0.003683 | 0.2668 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.855 | 0.7098 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.474 | 1.198 | 1.350 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.733 | 0.9212 | -0.5619 | -0.05855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1664 | -5.388 | 3.833 | 0.5854 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.924 | -2.927 | -2.102 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 480.58581 | 1.002 | -1.204 | -0.9224 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5395 | -0.9428 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6273 | -0.7688 | -0.6897 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.58581 | 94.23 | -5.604 | -1.011 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.856 | 0.7092 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.199 | 1.351 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.58581</span> | 94.23 | 0.003683 | 0.2668 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.856 | 0.7092 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.199 | 1.351 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.31 | 0.9226 | -0.5246 | -0.05019 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1134 | -5.293 | 3.771 | 0.5822 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.938 | -2.904 | -2.175 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 480.57360 | 1.001 | -1.205 | -0.9222 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5392 | -0.9437 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6271 | -0.7681 | -0.6894 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.5736 | 94.13 | -5.605 | -1.011 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.856 | 0.7085 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.200 | 1.351 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.5736</span> | 94.13 | 0.003678 | 0.2668 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.157 | 1.856 | 0.7085 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.200 | 1.351 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.864 | 0.9151 | -0.5515 | -0.06112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1679 | -5.184 | 3.617 | 0.5746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.832 | -2.849 | -2.141 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 480.56429 | 1.002 | -1.206 | -0.9220 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8502 | -0.5382 | -0.9446 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6268 | -0.7674 | -0.6889 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.56429 | 94.23 | -5.606 | -1.011 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7078 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.475 | 1.201 | 1.351 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.56429</span> | 94.23 | 0.003676 | 0.2669 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7078 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.475 | 1.201 | 1.351 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.18 | 0.9169 | -0.5105 | -0.05061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1125 | -5.131 | 3.532 | 0.5638 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.931 | -2.821 | -2.132 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 480.55246 | 1.001 | -1.207 | -0.9218 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5380 | -0.9454 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6266 | -0.7667 | -0.6886 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.55246 | 94.13 | -5.607 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.857 | 0.7071 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.201 | 1.352 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.55246</span> | 94.13 | 0.003672 | 0.2669 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.857 | 0.7071 | 0.7532 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.201 | 1.352 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.480 | 0.9098 | -0.5353 | -0.06055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1647 | -5.053 | 3.625 | 0.5654 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.860 | -2.782 | -2.112 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 480.54335 | 1.002 | -1.207 | -0.9217 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | -0.5368 | -0.9463 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6262 | -0.7660 | -0.6881 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.54335 | 94.23 | -5.607 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.858 | 0.7065 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.202 | 1.352 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.54335</span> | 94.23 | 0.003671 | 0.2669 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.858 | 0.7065 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.202 | 1.352 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.09 | 0.9120 | -0.4955 | -0.05014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1107 | -4.912 | 3.583 | 0.5835 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.814 | -2.702 | -2.057 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 480.53185 | 1.001 | -1.209 | -0.9215 | -0.9002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5366 | -0.9472 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6260 | -0.7654 | -0.6878 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.53185 | 94.13 | -5.609 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.858 | 0.7058 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 1.203 | 1.353 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.53185</span> | 94.13 | 0.003666 | 0.2670 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.158 | 1.858 | 0.7058 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.476 | 1.203 | 1.353 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.509 | 0.9048 | -0.5214 | -0.06027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1665 | -4.870 | 3.525 | 0.5641 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.813 | -2.699 | -2.069 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 480.52276 | 1.002 | -1.209 | -0.9214 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5356 | -0.9481 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6256 | -0.7647 | -0.6873 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.52276 | 94.22 | -5.609 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.859 | 0.7051 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.203 | 1.353 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.52276</span> | 94.22 | 0.003664 | 0.2670 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.859 | 0.7051 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.203 | 1.353 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.38 | 0.9060 | -0.4821 | -0.05014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1110 | -4.747 | 3.479 | 0.5798 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.777 | -2.636 | -2.020 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 480.51194 | 1.001 | -1.211 | -0.9212 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.5355 | -0.9490 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6255 | -0.7641 | -0.6869 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.51194 | 94.13 | -5.611 | -1.010 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.859 | 0.7044 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.204 | 1.354 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.51194</span> | 94.13 | 0.003659 | 0.2670 | 0.8148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.859 | 0.7044 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.204 | 1.354 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.485 | 0.8991 | -0.5064 | -0.06148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1643 | -4.758 | 3.403 | 0.5432 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.772 | -2.633 | -2.022 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 480.50302 | 1.002 | -1.211 | -0.9210 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5345 | -0.9500 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6251 | -0.7633 | -0.6864 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.50302 | 94.22 | -5.611 | -1.010 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.860 | 0.7037 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 1.205 | 1.354 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.50302</span> | 94.22 | 0.003656 | 0.2671 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.860 | 0.7037 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.205 | 1.354 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.83 | 0.8997 | -0.4680 | -0.05021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1106 | -4.703 | 3.332 | 0.5674 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.765 | -2.559 | -1.986 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 480.49281 | 1.001 | -1.213 | -0.9209 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.5344 | -0.9509 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6250 | -0.7627 | -0.6860 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.49281 | 94.13 | -5.613 | -1.009 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.860 | 0.7030 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.206 | 1.355 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.49281</span> | 94.13 | 0.003652 | 0.2671 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.860 | 0.7030 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.206 | 1.355 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.447 | 0.8934 | -0.4900 | -0.06030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1577 | -4.708 | 3.266 | 0.5080 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.782 | -2.544 | -1.983 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 480.48415 | 1.002 | -1.213 | -0.9207 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8498 | -0.5335 | -0.9518 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6246 | -0.7620 | -0.6855 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.48415 | 94.22 | -5.613 | -1.009 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7023 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.206 | 1.355 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.48415</span> | 94.22 | 0.003649 | 0.2671 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.861 | 0.7023 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.206 | 1.355 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.47 | 0.8932 | -0.4526 | -0.04997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1093 | -4.502 | 3.250 | 0.5653 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.769 | -2.486 | -1.944 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 480.47437 | 1.001 | -1.215 | -0.9205 | -0.9001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8498 | -0.5334 | -0.9527 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6244 | -0.7613 | -0.6852 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.47437 | 94.13 | -5.615 | -1.009 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7016 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 1.207 | 1.356 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.47437</span> | 94.13 | 0.003644 | 0.2672 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.161 | 1.861 | 0.7016 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.478 | 1.207 | 1.356 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.431 | 0.8869 | -0.4735 | -0.05983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1554 | -4.492 | 3.189 | -0.6996 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.700 | -2.467 | -1.937 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 480.46651 | 1.002 | -1.216 | -0.9203 | -0.9000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5326 | -0.9537 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6240 | -0.7606 | -0.6847 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.46651 | 94.21 | -5.616 | -1.009 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7009 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.208 | 1.356 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.46651</span> | 94.21 | 0.003640 | 0.2672 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.161 | 1.861 | 0.7009 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.208 | 1.356 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.502 | 0.8860 | -0.4381 | -0.05035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1103 | -4.453 | 3.114 | 0.5384 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.770 | -2.407 | -1.897 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 480.45755 | 1.001 | -1.217 | -0.9200 | -0.9000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5325 | -0.9546 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6238 | -0.7600 | -0.6843 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.45755 | 94.13 | -5.617 | -1.009 | -0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.861 | 0.7002 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.209 | 1.357 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.45755</span> | 94.13 | 0.003635 | 0.2673 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.861 | 0.7002 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.209 | 1.357 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.779 | 0.8798 | -0.4544 | -0.05816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1541 | -4.432 | 3.060 | 0.5236 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.719 | -2.365 | -1.874 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 480.44943 | 1.002 | -1.218 | -0.9199 | -0.9000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.5319 | -0.9555 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6235 | -0.7592 | -0.6838 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.44943 | 94.21 | -5.618 | -1.008 | -0.2046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.862 | 0.6995 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.479 | 1.209 | 1.357 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.44943</span> | 94.21 | 0.003631 | 0.2673 | 0.8149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.862 | 0.6995 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.479 | 1.209 | 1.357 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.806 | 0.8785 | -0.4202 | -0.05024 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1124 | -4.289 | 3.039 | 0.5974 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.651 | -2.322 | -1.843 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 480.44100 | 1.001 | -1.220 | -0.9197 | -0.9000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.5318 | -0.9564 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6233 | -0.7586 | -0.6835 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.441 | 94.13 | -5.620 | -1.008 | -0.2046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6988 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.210 | 1.358 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.441</span> | 94.13 | 0.003626 | 0.2673 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.862 | 0.6988 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.210 | 1.358 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.662 | 0.8724 | -0.4382 | -0.05735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1541 | -4.192 | 3.008 | 0.5718 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.633 | -2.283 | -1.828 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 480.43316 | 1.002 | -1.221 | -0.9195 | -0.9000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.5313 | -0.9573 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6230 | -0.7579 | -0.6830 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.43316 | 94.21 | -5.621 | -1.008 | -0.2046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6981 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.211 | 1.358 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.43316</span> | 94.21 | 0.003622 | 0.2674 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.862 | 0.6981 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.211 | 1.358 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.374 | 0.8709 | -0.4057 | -0.04981 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1077 | -4.274 | 2.898 | 0.5670 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.709 | -2.249 | -1.806 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 480.42514 | 1.001 | -1.222 | -0.9194 | -0.8999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.5312 | -0.9582 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6227 | -0.7573 | -0.6826 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.42514 | 94.13 | -5.622 | -1.008 | -0.2046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.862 | 0.6974 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.212 | 1.359 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.42514</span> | 94.13 | 0.003617 | 0.2674 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.862 | 0.6974 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.480 | 1.212 | 1.359 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.560 | 0.8648 | -0.4238 | -0.05673 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1505 | -4.130 | 2.894 | 0.5588 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.637 | -2.210 | -1.785 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 480.41757 | 1.002 | -1.223 | -0.9192 | -0.8999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5307 | -0.9591 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6223 | -0.7566 | -0.6821 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.41757 | 94.21 | -5.623 | -1.008 | -0.2046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6967 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.212 | 1.359 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.41757</span> | 94.21 | 0.003613 | 0.2674 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.164 | 1.863 | 0.6967 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.212 | 1.359 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.260 | 0.8632 | -0.3905 | -0.04898 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1050 | -4.163 | 2.793 | 0.5626 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.680 | -2.170 | -1.767 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 480.40986 | 1.001 | -1.225 | -0.9190 | -0.8999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8494 | -0.5306 | -0.9600 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6221 | -0.7560 | -0.6818 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.40986 | 94.13 | -5.625 | -1.008 | -0.2045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6961 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.213 | 1.360 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.40986</span> | 94.13 | 0.003607 | 0.2675 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.164 | 1.863 | 0.6961 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.213 | 1.360 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.433 | 0.8570 | -0.4082 | -0.05598 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1439 | -4.083 | 2.776 | -0.7191 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.623 | -2.134 | -1.744 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 480.40309 | 1.002 | -1.226 | -0.9188 | -0.8999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8493 | -0.5301 | -0.9609 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6217 | -0.7553 | -0.6813 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.40309 | 94.20 | -5.626 | -1.007 | -0.2045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6954 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | 1.214 | 1.360 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.40309</span> | 94.20 | 0.003603 | 0.2675 | 0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.165 | 1.863 | 0.6954 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.481 | 1.214 | 1.360 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.640 | 0.8551 | -0.3719 | -0.04853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1037 | -4.111 | 2.689 | 0.5674 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.653 | -2.095 | -1.726 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 480.39597 | 1.001 | -1.227 | -0.9185 | -0.8998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8492 | -0.5300 | -0.9618 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6215 | -0.7547 | -0.6809 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.39597 | 94.13 | -5.627 | -1.007 | -0.2045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.863 | 0.6947 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.214 | 1.361 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.39597</span> | 94.13 | 0.003598 | 0.2676 | 0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.165 | 1.863 | 0.6947 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.214 | 1.361 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.827 | 0.8487 | -0.3865 | -0.05558 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1453 | -3.997 | 2.662 | 0.5449 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.580 | -2.061 | -1.701 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 480.38900 | 1.002 | -1.229 | -0.9184 | -0.8998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.5297 | -0.9626 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6211 | -0.7540 | -0.6805 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.389 | 94.20 | -5.629 | -1.007 | -0.2044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6940 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.215 | 1.361 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.389</span> | 94.20 | 0.003593 | 0.2676 | 0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.864 | 0.6940 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.215 | 1.361 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.052 | 0.8465 | -0.3544 | -0.04836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1022 | -3.917 | 2.636 | 0.5926 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.553 | -2.027 | -1.689 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 480.38219 | 1.001 | -1.230 | -0.9183 | -0.8998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.5296 | -0.9634 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6209 | -0.7534 | -0.6801 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.38219 | 94.13 | -5.630 | -1.007 | -0.2044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6934 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 1.216 | 1.362 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.38219</span> | 94.13 | 0.003587 | 0.2676 | 0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 1.864 | 0.6934 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.216 | 1.362 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.619 | 0.8406 | -0.3725 | -0.05439 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1411 | -3.915 | 2.594 | -0.6808 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.519 | -1.986 | -1.659 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 480.37598 | 1.002 | -1.232 | -0.9180 | -0.8998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8490 | -0.5292 | -0.9644 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6206 | -0.7528 | -0.6796 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.37598 | 94.20 | -5.632 | -1.007 | -0.2044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6927 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.216 | 1.362 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.37598</span> | 94.20 | 0.003582 | 0.2677 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.864 | 0.6927 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.216 | 1.362 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.566 | 0.8383 | -0.3380 | -0.04700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09943 | -3.949 | 2.377 | 0.5751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.561 | -1.951 | -1.641 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 480.36982 | 1.001 | -1.233 | -0.9178 | -0.8997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5291 | -0.9651 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6204 | -0.7522 | -0.6792 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.36982 | 94.12 | -5.633 | -1.006 | -0.2043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6922 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.217 | 1.363 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.36982</span> | 94.12 | 0.003577 | 0.2677 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.167 | 1.864 | 0.6922 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.217 | 1.363 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.243 | 0.8317 | -0.3515 | -0.05392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1358 | -3.830 | 2.493 | 0.5823 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.510 | -1.918 | -1.620 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 480.36331 | 1.002 | -1.235 | -0.9176 | -0.8997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5289 | -0.9659 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6201 | -0.7516 | -0.6788 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.36331 | 94.19 | -5.635 | -1.006 | -0.2043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6916 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 1.218 | 1.363 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.36331</span> | 94.19 | 0.003572 | 0.2677 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.864 | 0.6916 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.483 | 1.218 | 1.363 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.492 | 0.8288 | -0.3226 | -0.04732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09956 | -3.829 | 2.435 | 0.5676 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.517 | -1.882 | -1.604 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 480.35731 | 1.001 | -1.236 | -0.9175 | -0.8996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.5288 | -0.9666 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6198 | -0.7510 | -0.6783 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.35731 | 94.12 | -5.636 | -1.006 | -0.2043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6910 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.218 | 1.364 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.35731</span> | 94.12 | 0.003566 | 0.2678 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 1.864 | 0.6910 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.218 | 1.364 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.442 | 0.8230 | -0.3401 | -0.05270 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1329 | -3.818 | 2.394 | -0.6865 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.462 | -1.826 | -1.568 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 480.35158 | 1.002 | -1.238 | -0.9173 | -0.8996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.5286 | -0.9675 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6197 | -0.7504 | -0.6779 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.35158 | 94.19 | -5.638 | -1.006 | -0.2042 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.864 | 0.6904 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.219 | 1.364 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.35158</span> | 94.19 | 0.003561 | 0.2678 | 0.8153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.169 | 1.864 | 0.6904 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.219 | 1.364 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.119 | 0.8198 | -0.3066 | -0.04724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1005 | -3.787 | 2.338 | 0.5896 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.465 | -1.812 | -1.559 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 480.34603 | 1.001 | -1.239 | -0.9170 | -0.8996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8486 | -0.5283 | -0.9683 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.7499 | -0.6775 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.34603 | 94.12 | -5.639 | -1.006 | -0.2042 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.865 | 0.6897 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.220 | 1.364 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.34603</span> | 94.12 | 0.003555 | 0.2679 | 0.8153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.865 | 0.6897 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.220 | 1.364 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.669 | 0.8137 | -0.3182 | -0.05158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1292 | -3.845 | 2.251 | 0.5349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.532 | -1.781 | -1.537 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 480.33997 | 1.002 | -1.241 | -0.9169 | -0.8995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8486 | -0.5282 | -0.9690 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6192 | -0.7493 | -0.6772 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.33997 | 94.19 | -5.641 | -1.005 | -0.2041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6892 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 1.220 | 1.365 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.33997</span> | 94.19 | 0.003550 | 0.2679 | 0.8153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 1.865 | 0.6892 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.484 | 1.220 | 1.365 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.944 | 0.8109 | -0.2900 | -0.04418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09220 | -3.817 | 2.207 | 0.5423 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.530 | -1.750 | -1.524 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 480.33440 | 1.001 | -1.242 | -0.9168 | -0.8995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5280 | -0.9697 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6188 | -0.7487 | -0.6768 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.3344 | 94.12 | -5.642 | -1.005 | -0.2041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6887 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.485 | 1.221 | 1.365 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.3344</span> | 94.12 | 0.003544 | 0.2679 | 0.8154 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.865 | 0.6887 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.485 | 1.221 | 1.365 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.630 | 0.8048 | -0.3070 | -0.04965 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1246 | -3.770 | 2.179 | 0.5400 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.465 | -1.710 | -1.500 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 480.32852 | 1.002 | -1.244 | -0.9167 | -0.8994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8485 | -0.5278 | -0.9703 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6184 | -0.7482 | -0.6764 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.32852 | 94.19 | -5.644 | -1.005 | -0.2041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6882 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.485 | 1.221 | 1.366 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.32852</span> | 94.19 | 0.003538 | 0.2679 | 0.8154 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.171 | 1.865 | 0.6882 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.485 | 1.221 | 1.366 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.819 | 0.8018 | -0.2789 | -0.04260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08823 | -3.653 | 2.177 | -0.6593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.384 | -1.678 | -1.478 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 480.32382 | 1.001 | -1.246 | -0.9164 | -0.8994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8484 | -0.5276 | -0.9711 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6183 | -0.7477 | -0.6761 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.32382 | 94.12 | -5.646 | -1.005 | -0.2040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6876 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.222 | 1.366 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.32382</span> | 94.12 | 0.003533 | 0.2680 | 0.8155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.865 | 0.6876 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.222 | 1.366 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.225 | 0.7951 | -0.2896 | -0.04843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1194 | -3.720 | 2.091 | -0.7072 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.430 | -1.641 | -1.454 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 480.31902 | 1.002 | -1.247 | -0.9160 | -0.8993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8482 | -0.5273 | -0.9719 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6182 | -0.7473 | -0.6757 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.31902 | 94.19 | -5.647 | -1.005 | -0.2039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.865 | 0.6870 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.222 | 1.367 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31902</span> | 94.19 | 0.003527 | 0.2681 | 0.8155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.173 | 1.865 | 0.6870 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.222 | 1.367 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.904 | 0.7922 | -0.2469 | -0.04034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08539 | -3.545 | 2.094 | -0.6237 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.331 | -1.619 | -1.454 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 480.31471 | 1.001 | -1.249 | -0.9156 | -0.8993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.5271 | -0.9727 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6181 | -0.7468 | -0.6753 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.31471 | 94.12 | -5.649 | -1.004 | -0.2039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6864 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.223 | 1.367 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31471</span> | 94.12 | 0.003522 | 0.2681 | 0.8156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 1.866 | 0.6864 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.223 | 1.367 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.295 | 0.7853 | -0.2507 | -0.04627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1126 | -3.760 | 1.942 | -0.7288 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.482 | -1.617 | -1.436 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 480.31013 | 1.002 | -1.250 | -0.9152 | -0.8992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8480 | -0.5269 | -0.9734 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6180 | -0.7464 | -0.6750 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.31013 | 94.19 | -5.650 | -1.004 | -0.2038 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6859 | 0.7535 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.223 | 1.367 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.31013</span> | 94.19 | 0.003516 | 0.2682 | 0.8156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.175 | 1.866 | 0.6859 | 0.7535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.223 | 1.367 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.435 | 0.7821 | -0.2118 | -0.03855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07590 | -3.495 | 2.000 | -0.6027 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.382 | -1.576 | -1.413 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 480.30581 | 1.001 | -1.252 | -0.9149 | -0.8991 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8479 | -0.5266 | -0.9741 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6178 | -0.7459 | -0.6746 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.30581 | 94.12 | -5.652 | -1.003 | -0.2037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6854 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.224 | 1.368 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.30581</span> | 94.12 | 0.003510 | 0.2683 | 0.8157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.176 | 1.866 | 0.6854 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.224 | 1.368 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.315 | 0.7789 | -0.2090 | -0.03720 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09944 | -3.577 | 1.911 | -0.6518 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.378 | -1.528 | -1.376 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 480.30125 | 1.002 | -1.254 | -0.9146 | -0.8990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8478 | -0.5264 | -0.9748 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6176 | -0.7454 | -0.6743 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.30125 | 94.19 | -5.654 | -1.003 | -0.2037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6848 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 1.224 | 1.368 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.30125</span> | 94.19 | 0.003505 | 0.2683 | 0.8157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.177 | 1.866 | 0.6848 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.486 | 1.224 | 1.368 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.353 | 0.7723 | -0.1834 | -0.03622 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07047 | -3.672 | 1.822 | -0.6713 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.445 | -1.532 | -1.389 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 480.29714 | 1.001 | -1.255 | -0.9143 | -0.8990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5261 | -0.9754 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6174 | -0.7450 | -0.6740 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.29714 | 94.12 | -5.655 | -1.003 | -0.2036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.866 | 0.6843 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.225 | 1.369 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.29714</span> | 94.12 | 0.003499 | 0.2684 | 0.8158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.178 | 1.866 | 0.6843 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.225 | 1.369 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.435 | 0.7663 | -0.1878 | -0.03986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1019 | -3.343 | 1.893 | 0.6711 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.269 | -1.487 | -1.354 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 480.29215 | 1.002 | -1.257 | -0.9143 | -0.8989 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5260 | -0.9760 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6172 | -0.7444 | -0.6736 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.29215 | 94.18 | -5.657 | -1.003 | -0.2036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6839 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.226 | 1.369 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.29215</span> | 94.18 | 0.003493 | 0.2684 | 0.8158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6839 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.226 | 1.369 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.161 | 0.7621 | -0.1686 | -0.03452 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06632 | -3.552 | 1.775 | 0.6057 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.379 | -1.473 | -1.364 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 480.28721 | 1.001 | -1.259 | -0.9145 | -0.8989 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.5257 | -0.9765 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6170 | -0.7439 | -0.6732 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.28721 | 94.12 | -5.659 | -1.003 | -0.2035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6836 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.226 | 1.369 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.28721</span> | 94.12 | 0.003487 | 0.2684 | 0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6836 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.226 | 1.369 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.925 | 0.7584 | -0.1913 | -0.03513 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09132 | -3.418 | 1.781 | -0.6203 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.349 | -1.417 | -1.313 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 480.28278 | 1.002 | -1.260 | -0.9144 | -0.8988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8475 | -0.5255 | -0.9770 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6167 | -0.7434 | -0.6728 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.28278 | 94.19 | -5.660 | -1.003 | -0.2035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6832 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.487 | 1.227 | 1.370 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.28278</span> | 94.19 | 0.003481 | 0.2684 | 0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.179 | 1.867 | 0.6832 | 0.7537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.487 | 1.227 | 1.370 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.442 | 0.7524 | -0.1734 | -0.03276 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06267 | -3.400 | 1.746 | -0.5960 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.307 | -1.411 | -1.323 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 480.27897 | 1.001 | -1.262 | -0.9141 | -0.8988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8474 | -0.5252 | -0.9776 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6165 | -0.7431 | -0.6724 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.27897 | 94.13 | -5.662 | -1.003 | -0.2034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6827 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.227 | 1.370 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.27897</span> | 94.13 | 0.003475 | 0.2684 | 0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.180 | 1.867 | 0.6827 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.227 | 1.370 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.732 | 0.7463 | -0.1764 | -0.03625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08933 | -3.375 | 1.716 | 0.6486 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.273 | -1.374 | -1.283 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 480.27440 | 1.002 | -1.264 | -0.9140 | -0.8987 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8473 | -0.5250 | -0.9782 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6164 | -0.7427 | -0.6721 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.2744 | 94.19 | -5.664 | -1.003 | -0.2034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.867 | 0.6823 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.227 | 1.371 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2744</span> | 94.19 | 0.003469 | 0.2684 | 0.8160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.181 | 1.867 | 0.6823 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.227 | 1.371 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.305 | 0.7431 | -0.1535 | -0.02884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05624 | -3.424 | 1.641 | -0.6166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.366 | -1.368 | -1.291 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 480.27043 | 1.001 | -1.266 | -0.9140 | -0.8987 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8473 | -0.5247 | -0.9786 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6161 | -0.7423 | -0.6718 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.27043 | 94.13 | -5.666 | -1.002 | -0.2033 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6819 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.228 | 1.371 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.27043</span> | 94.13 | 0.003463 | 0.2685 | 0.8160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.181 | 1.868 | 0.6819 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.228 | 1.371 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.306 | 0.7372 | -0.1665 | -0.03186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08221 | -3.333 | 1.631 | -0.6040 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.265 | -1.322 | -1.255 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 480.26665 | 1.002 | -1.267 | -0.9136 | -0.8986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.5244 | -0.9791 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6160 | -0.7419 | -0.6714 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.26665 | 94.19 | -5.667 | -1.002 | -0.2032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6815 | 0.7540 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.228 | 1.371 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.26665</span> | 94.19 | 0.003457 | 0.2685 | 0.8161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.182 | 1.868 | 0.6815 | 0.7540 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.228 | 1.371 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.654 | 0.7327 | -0.1326 | -0.02617 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04981 | -3.394 | 1.559 | -0.6139 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.358 | -1.341 | -1.268 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 480.26300 | 1.001 | -1.269 | -0.9132 | -0.8985 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8470 | -0.5241 | -0.9796 | -1.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6158 | -0.7416 | -0.6711 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.263 | 94.13 | -5.669 | -1.002 | -0.2032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6812 | 0.7542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.229 | 1.372 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.263</span> | 94.13 | 0.003451 | 0.2686 | 0.8162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.183 | 1.868 | 0.6812 | 0.7542 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.229 | 1.372 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.009 | 0.7258 | -0.1343 | -0.03035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07619 | -3.164 | 1.609 | -0.5397 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.251 | -1.282 | -1.219 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 480.25930 | 1.002 | -1.271 | -0.9130 | -0.8985 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5239 | -0.9802 | -1.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6155 | -0.7412 | -0.6708 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.2593 | 94.19 | -5.671 | -1.002 | -0.2031 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6807 | 0.7543 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 1.229 | 1.372 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2593</span> | 94.19 | 0.003445 | 0.2686 | 0.8162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.868 | 0.6807 | 0.7543 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.489 | 1.229 | 1.372 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.851 | 0.7223 | -0.1045 | -0.02290 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04316 | -3.376 | 1.478 | 0.6193 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.343 | -1.302 | -1.232 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 480.25486 | 1.001 | -1.273 | -0.9131 | -0.8984 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5237 | -0.9805 | -1.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6152 | -0.7408 | -0.6705 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.25486 | 94.14 | -5.673 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.868 | 0.6805 | 0.7542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 1.230 | 1.373 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.25486</span> | 94.14 | 0.003439 | 0.2686 | 0.8162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.868 | 0.6805 | 0.7542 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.489 | 1.230 | 1.373 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.282 | 0.7167 | -0.1236 | -0.02586 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06793 | -3.294 | 1.470 | 0.6693 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.247 | -1.242 | -1.194 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 480.25000 | 1.002 | -1.274 | -0.9134 | -0.8984 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5231 | -0.9806 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6147 | -0.7402 | -0.6701 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.25 | 94.20 | -5.674 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6804 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.230 | 1.373 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.25</span> | 94.20 | 0.003434 | 0.2686 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6804 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.230 | 1.373 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.823 | 0.7134 | -0.1173 | -0.02040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04062 | -3.151 | 1.491 | -0.5685 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.243 | -1.237 | -1.210 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 480.24598 | 1.001 | -1.276 | -0.9134 | -0.8984 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5229 | -0.9809 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6145 | -0.7399 | -0.6698 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.24598 | 94.13 | -5.676 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6802 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.231 | 1.373 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.24598</span> | 94.13 | 0.003427 | 0.2686 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6802 | 0.7539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.231 | 1.373 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.294 | 0.7076 | -0.1362 | -0.02383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06566 | -3.147 | 1.461 | 0.6663 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.244 | -1.185 | -1.155 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 480.24152 | 1.002 | -1.278 | -0.9134 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5225 | -0.9813 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6142 | -0.7395 | -0.6694 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.24152 | 94.19 | -5.678 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6799 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 1.231 | 1.374 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.24152</span> | 94.19 | 0.003421 | 0.2686 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6799 | 0.7538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.490 | 1.231 | 1.374 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.573 | 0.7031 | -0.1214 | -0.01999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04022 | -3.129 | 1.425 | 0.6287 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.274 | -1.197 | -1.174 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 480.23703 | 1.001 | -1.280 | -0.9136 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5223 | -0.9815 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6136 | -0.7392 | -0.6691 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.23703 | 94.13 | -5.680 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.869 | 0.6797 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 1.231 | 1.374 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23703</span> | 94.13 | 0.003415 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.869 | 0.6797 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.491 | 1.231 | 1.374 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.496 | 0.6977 | -0.1464 | -0.02500 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06997 | -3.031 | 1.316 | 0.6455 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.198 | -1.144 | -1.124 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 480.23246 | 1.002 | -1.281 | -0.9138 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5219 | -0.9816 | -1.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6131 | -0.7387 | -0.6687 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.23246 | 94.19 | -5.681 | -1.002 | -0.2030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6796 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23246</span> | 94.19 | 0.003409 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6796 | 0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.825 | 0.6940 | -0.1347 | -0.01919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03939 | -3.118 | 1.378 | 0.5922 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.219 | -1.136 | -1.127 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 480.22809 | 1.001 | -1.283 | -0.9138 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5217 | -0.9816 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6127 | -0.7384 | -0.6684 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.22809 | 94.14 | -5.683 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6796 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22809</span> | 94.14 | 0.003403 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6796 | 0.7531 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.001 | 0.6885 | -0.1518 | -0.02256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06414 | -2.892 | 1.443 | 0.6415 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -1.098 | -1.101 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 480.22387 | 1.002 | -1.285 | -0.9139 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5212 | -0.9821 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6124 | -0.7381 | -0.6680 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.22387 | 94.19 | -5.685 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.870 | 0.6793 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.232 | 1.375 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22387</span> | 94.19 | 0.003397 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.870 | 0.6793 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.232 | 1.375 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.360 | 0.6846 | -0.1392 | -0.01938 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04006 | -2.853 | 1.421 | -0.5715 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -1.117 | -1.118 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 480.22054 | 1.001 | -1.287 | -0.9139 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5210 | -0.9826 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6125 | -0.7380 | -0.6676 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.22054 | 94.14 | -5.687 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6789 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 1.233 | 1.376 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.22054</span> | 94.14 | 0.003391 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6789 | 0.7530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.492 | 1.233 | 1.376 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.774 | 0.6781 | -0.1521 | -0.02419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06697 | -2.800 | 1.392 | 0.6467 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.111 | -1.074 | -1.064 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 480.21670 | 1.002 | -1.288 | -0.9138 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5206 | -0.9832 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6123 | -0.7378 | -0.6672 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.2167 | 94.19 | -5.688 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6784 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 1.233 | 1.376 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2167</span> | 94.19 | 0.003385 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6784 | 0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.493 | 1.233 | 1.376 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.519 | 0.6730 | -0.1351 | -0.02088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04118 | -2.856 | 1.311 | 0.6094 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.165 | -1.062 | -1.048 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 480.21269 | 1.001 | -1.290 | -0.9139 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5205 | -0.9835 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6119 | -0.7376 | -0.6670 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.21269 | 94.14 | -5.690 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6782 | 0.7527 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 1.233 | 1.377 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.21269</span> | 94.14 | 0.003379 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6782 | 0.7527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.493 | 1.233 | 1.377 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.933 | 0.6686 | -0.1517 | -0.01805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06304 | -2.806 | 1.298 | 0.6045 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.073 | -1.045 | -1.026 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 480.20865 | 1.002 | -1.292 | -0.9139 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8469 | -0.5201 | -0.9839 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6115 | -0.7373 | -0.6667 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.20865 | 94.19 | -5.692 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6779 | 0.7525 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.233 | 1.377 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20865</span> | 94.19 | 0.003373 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.184 | 1.871 | 0.6779 | 0.7525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.233 | 1.377 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.802 | 0.6647 | -0.1367 | -0.01906 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03994 | -2.699 | 1.311 | -0.5807 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.078 | -1.030 | -1.030 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 480.20558 | 1.001 | -1.294 | -0.9137 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8468 | -0.5199 | -0.9842 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6113 | -0.7372 | -0.6665 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.20558 | 94.14 | -5.694 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.871 | 0.6776 | 0.7525 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.233 | 1.377 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20558</span> | 94.14 | 0.003367 | 0.2685 | 0.8163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.185 | 1.871 | 0.6776 | 0.7525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.233 | 1.377 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.911 | 0.6576 | -0.1438 | -0.02051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06613 | -2.751 | 1.246 | -0.6218 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -1.017 | -1.010 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 480.20291 | 1.002 | -1.296 | -0.9132 | -0.8982 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.5195 | -0.9848 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6112 | -0.7370 | -0.6662 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.20291 | 94.19 | -5.696 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 1.872 | 0.6772 | 0.7527 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.377 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.20291</span> | 94.19 | 0.003361 | 0.2686 | 0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 1.872 | 0.6772 | 0.7527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.377 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.296 | 0.6533 | -0.1055 | -0.01383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03435 | -2.750 | 1.192 | -0.6155 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.121 | -1.037 | -1.054 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 480.20010 | 1.001 | -1.297 | -0.9127 | -0.8982 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5193 | -0.9850 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6110 | -0.7368 | -0.6658 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.2001 | 94.14 | -5.697 | -1.001 | -0.2028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6771 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.378 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.2001</span> | 94.14 | 0.003355 | 0.2687 | 0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6771 | 0.7528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.378 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.841 | 0.6461 | -0.09617 | -0.01892 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05600 | -2.503 | 1.255 | 0.6797 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9587 | -1.006 | -0.9794 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 480.19652 | 1.002 | -1.299 | -0.9127 | -0.8982 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5191 | -0.9853 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6108 | -0.7364 | -0.6653 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.19652 | 94.19 | -5.699 | -1.001 | -0.2028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6768 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.234 | 1.378 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.19652</span> | 94.19 | 0.003349 | 0.2687 | 0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6768 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.234 | 1.378 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 480.19461 | 1.002 | -1.301 | -0.9128 | -0.8982 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5193 | -0.9855 | -1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6107 | -0.7361 | -0.6650 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.19461 | 94.18 | -5.701 | -1.001 | -0.2028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.872 | 0.6767 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 1.235 | 1.379 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.19461</span> | 94.18 | 0.003342 | 0.2687 | 0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.872 | 0.6767 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.235 | 1.379 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 480.18441 | 1.002 | -1.313 | -0.9134 | -0.8983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5209 | -0.9862 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6104 | -0.7344 | -0.6628 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.18441 | 94.17 | -5.713 | -1.002 | -0.2029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.871 | 0.6762 | 0.7522 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 1.237 | 1.381 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.18441</span> | 94.17 | 0.003303 | 0.2686 | 0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.871 | 0.6762 | 0.7522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.495 | 1.237 | 1.381 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 480.15712 | 1.001 | -1.360 | -0.9157 | -0.8984 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8466 | -0.5271 | -0.9890 | -1.004 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6089 | -0.7277 | -0.6540 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.15712 | 94.12 | -5.760 | -1.004 | -0.2031 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.866 | 0.6740 | 0.7509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 1.244 | 1.391 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.15712</span> | 94.12 | 0.003151 | 0.2681 | 0.8162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.866 | 0.6740 | 0.7509 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.497 | 1.244 | 1.391 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 480.23418 | 0.9997 | -1.543 | -0.9246 | -0.8991 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8465 | -0.5509 | -1.000 | -1.011 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6032 | -0.7017 | -0.6198 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.23418 | 93.97 | -5.943 | -1.013 | -0.2037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 1.847 | 0.6655 | 0.7454 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.503 | 1.272 | 1.431 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.23418</span> | 93.97 | 0.002624 | 0.2664 | 0.8157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.187 | 1.847 | 0.6655 | 0.7454 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.503 | 1.272 | 1.431 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.048 | 0.4781 | -0.2230 | -0.02217 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05480 | -3.577 | 0.9301 | 0.6494 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.028 | -0.4525 | -0.4232 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 480.10748 | 1.002 | -1.612 | -0.8919 | -0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8419 | -0.5057 | -1.005 | -1.011 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6089 | -0.7402 | -0.6757 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.10748 | 94.20 | -6.012 | -0.9804 | -0.2001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.107 | 1.883 | 0.6618 | 0.7449 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 1.230 | 1.367 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.10748</span> | 94.20 | 0.002450 | 0.2728 | 0.8186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.225 | 1.883 | 0.6618 | 0.7449 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.497 | 1.230 | 1.367 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.588 | -0.2032 | 1.050 | 0.05863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1556 | -1.013 | -0.1797 | 0.1430 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -1.192 | -1.504 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 480.44664 | 1.003 | -1.804 | -0.9880 | -0.8940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8524 | -0.4601 | -0.9127 | -1.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5485 | -0.7099 | -0.6226 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.44664 | 94.31 | -6.204 | -1.077 | -0.1987 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.097 | 1.919 | 0.7320 | 0.7196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 1.263 | 1.427 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.44664</span> | 94.31 | 0.002022 | 0.2542 | 0.8198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.139 | 1.919 | 0.7320 | 0.7196 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.568 | 1.263 | 1.427 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 480.05051 | 1.002 | -1.657 | -0.9147 | -0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8444 | -0.4949 | -0.9832 | -1.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5946 | -0.7329 | -0.6630 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.05051 | 94.19 | -6.057 | -1.003 | -0.1998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.105 | 1.891 | 0.6784 | 0.7389 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.514 | 1.238 | 1.381 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.05051</span> | 94.19 | 0.002341 | 0.2683 | 0.8189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.205 | 1.891 | 0.6784 | 0.7389 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.514 | 1.238 | 1.381 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.048 | -0.2764 | -0.02525 | 0.07726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1002 | 0.1555 | 1.072 | 0.1458 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5013 | -0.7465 | -0.9442 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 480.05873 | 1.002 | -1.641 | -0.9145 | -0.9051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8597 | -0.5017 | -0.9961 | -1.019 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5552 | -0.7600 | -0.6392 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.05873 | 94.21 | -6.041 | -1.003 | -0.2097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.089 | 1.886 | 0.6686 | 0.7381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.561 | 1.209 | 1.408 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.05873</span> | 94.21 | 0.002380 | 0.2684 | 0.8108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.080 | 1.886 | 0.6686 | 0.7381 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.561 | 1.209 | 1.408 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 480.03299 | 1.002 | -1.650 | -0.9146 | -0.8993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8508 | -0.4977 | -0.9887 | -1.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5780 | -0.7442 | -0.6529 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.03299 | 94.17 | -6.050 | -1.003 | -0.2040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.098 | 1.889 | 0.6742 | 0.7386 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.533 | 1.226 | 1.393 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.03299</span> | 94.17 | 0.002357 | 0.2683 | 0.8155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.152 | 1.889 | 0.6742 | 0.7386 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.533 | 1.226 | 1.393 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.07884 | -0.2508 | -0.03233 | -0.02314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1302 | 0.06288 | 0.7629 | 0.2261 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3850 | -1.277 | -0.6610 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 480.00970 | 1.003 | -1.641 | -0.9125 | -0.9005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4980 | -0.9983 | -1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5841 | -0.7275 | -0.6414 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.0097 | 94.26 | -6.041 | -1.001 | -0.2051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6670 | 0.7367 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.244 | 1.406 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.0097</span> | 94.26 | 0.002380 | 0.2687 | 0.8145 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6670 | 0.7367 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.244 | 1.406 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.51 | -0.2151 | 0.1066 | -0.04414 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06212 | -0.2557 | 0.09002 | -0.09728 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.06582 | -0.3883 | 0.07016 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 480.02569 | 1.000 | -1.627 | -0.9257 | -0.9015 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8496 | -0.4974 | -1.010 | -1.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5876 | -0.7200 | -0.6493 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.02569 | 94.03 | -6.027 | -1.014 | -0.2061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6581 | 0.7348 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.522 | 1.252 | 1.397 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.02569</span> | 94.03 | 0.002413 | 0.2662 | 0.8138 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.889 | 0.6581 | 0.7348 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.522 | 1.252 | 1.397 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 480.01783 | 1.000 | -1.636 | -0.9171 | -0.9008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8499 | -0.4978 | -1.002 | -1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5853 | -0.7249 | -0.6441 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.01783 | 94.03 | -6.036 | -1.006 | -0.2055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6639 | 0.7361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.525 | 1.247 | 1.403 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.01783</span> | 94.03 | 0.002392 | 0.2678 | 0.8143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.160 | 1.889 | 0.6639 | 0.7361 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.525 | 1.247 | 1.403 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 480.01762 | 1.000 | -1.639 | -0.9140 | -0.9006 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4979 | -0.9995 | -1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5844 | -0.7266 | -0.6422 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.01762 | 94.04 | -6.039 | -1.002 | -0.2052 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6660 | 0.7365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.245 | 1.405 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.01762</span> | 94.04 | 0.002384 | 0.2685 | 0.8145 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6660 | 0.7365 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.245 | 1.405 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 480.00603 | 1.001 | -1.641 | -0.9125 | -0.9005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8500 | -0.4980 | -0.9983 | -1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5841 | -0.7275 | -0.6414 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.00603 | 94.12 | -6.041 | -1.001 | -0.2051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6670 | 0.7367 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.526 | 1.244 | 1.406 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00603</span> | 94.12 | 0.002380 | 0.2687 | 0.8145 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.159 | 1.889 | 0.6670 | 0.7367 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.526 | 1.244 | 1.406 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.885 | -0.2187 | 0.06031 | -0.05864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1316 | -0.6942 | -0.07940 | 0.7419 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2628 | -0.6303 | -0.1748 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 480.00355 | 1.002 | -1.640 | -0.9125 | -0.9004 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.4981 | -0.9983 | -1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5835 | -0.7267 | -0.6420 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.00355 | 94.17 | -6.040 | -1.001 | -0.2050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.099 | 1.889 | 0.6669 | 0.7366 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.527 | 1.245 | 1.405 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00355</span> | 94.17 | 0.002382 | 0.2687 | 0.8147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.162 | 1.889 | 0.6669 | 0.7366 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.245 | 1.405 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1332 | -0.2152 | 0.07761 | -0.04946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09731 | -0.07704 | 0.1258 | 0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.08309 | -0.3432 | 0.03979 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 480.00003 | 1.002 | -1.640 | -0.9126 | -0.9003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8495 | -0.4980 | -0.9985 | -1.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5836 | -0.7262 | -0.6420 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.00003 | 94.19 | -6.040 | -1.001 | -0.2049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 1.889 | 0.6668 | 0.7355 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.527 | 1.245 | 1.405 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.00003</span> | 94.19 | 0.002382 | 0.2687 | 0.8147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.163 | 1.889 | 0.6668 | 0.7355 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.245 | 1.405 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.294 | -0.2073 | 0.08146 | -0.04541 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07807 | -0.2293 | 0.05730 | 0.8075 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.008164 | -0.3171 | 0.03808 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 479.99578 | 1.002 | -1.638 | -0.9109 | -0.8997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8483 | -0.4984 | -0.9975 | -1.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5809 | -0.7230 | -0.6440 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.99578 | 94.17 | -6.038 | -0.9994 | -0.2043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 1.889 | 0.6675 | 0.7343 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.530 | 1.249 | 1.403 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.99578</span> | 94.17 | 0.002387 | 0.2691 | 0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.172 | 1.889 | 0.6675 | 0.7343 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.530 | 1.249 | 1.403 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 479.99301 | 1.002 | -1.632 | -0.9055 | -0.8980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8447 | -0.4999 | -0.9947 | -1.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5728 | -0.7134 | -0.6498 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.99301 | 94.16 | -6.032 | -0.9941 | -0.2026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.104 | 1.887 | 0.6697 | 0.7310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.540 | 1.259 | 1.396 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.99301</span> | 94.16 | 0.002402 | 0.2701 | 0.8166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.202 | 1.887 | 0.6697 | 0.7310 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.540 | 1.259 | 1.396 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.5972 | -0.1625 | 0.4650 | 0.009686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08636 | -1.694 | -0.1652 | -1.042 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1517 | 0.4204 | -0.3659 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 479.98697 | 1.002 | -1.611 | -0.9101 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8385 | -0.4966 | -0.9980 | -1.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5750 | -0.7140 | -0.6459 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.98697 | 94.17 | -6.011 | -0.9986 | -0.1991 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.111 | 1.890 | 0.6672 | 0.7309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.537 | 1.259 | 1.401 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.98697</span> | 94.17 | 0.002451 | 0.2692 | 0.8195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.253 | 1.890 | 0.6672 | 0.7309 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.537 | 1.259 | 1.401 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.005684 | -0.1115 | 0.2082 | 0.08938 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3008 | 0.01411 | 0.1052 | -0.7061 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.4111 | 0.4010 | -0.1199 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 479.98697 | 1.002 | -1.611 | -0.9101 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8385 | -0.4966 | -0.9980 | -1.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5750 | -0.7140 | -0.6459 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.98697 | 94.17 | -6.011 | -0.9986 | -0.1991 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.111 | 1.890 | 0.6672 | 0.7309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.537 | 1.259 | 1.401 |...........|</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.98697</span> | 94.17 | 0.002451 | 0.2692 | 0.8195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.253 | 1.890 | 0.6672 | 0.7309 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.537 | 1.259 | 1.401 |...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_const</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_const</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma | o1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o6 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 517.20934 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 517.20934 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 517.20934</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 64.43 | 1.648 | -0.07882 | -0.2050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4304 | 0.05992 | -56.51 | 17.73 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.983 | -11.00 | -3.771 | 3.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.58 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2737.3115 | 0.2806 | -1.018 | -0.9100 | -0.9273 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9731 | -0.8892 | -0.2282 | -1.075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9854 | -0.7447 | -0.8291 | -0.9136 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7499 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 2737.3115 | 26.38 | -5.418 | -0.9691 | -1.898 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.295 | 0.1399 | 2.105 | 0.5864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 1.329 | 1.042 | 0.8535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2737.3115</span> | 26.38 | 0.004434 | 0.2751 | 0.1499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01363 | 0.5349 | 2.105 | 0.5864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7671 | 1.329 | 1.042 | 0.8535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 569.57476 | 0.9281 | -1.002 | -0.9108 | -0.9293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9774 | -0.8886 | -0.7961 | -0.8964 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8851 | -0.8553 | -0.8670 | -0.8775 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8562 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 569.57476 | 87.24 | -5.402 | -0.9699 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.650 | 0.7166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8537 | 1.198 | 1.004 | 0.8856 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.175 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 569.57476</span> | 87.24 | 0.004508 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01358 | 0.5349 | 1.650 | 0.7166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8537 | 1.198 | 1.004 | 0.8856 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.175 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 531.41065 | 0.9928 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9778 | -0.8885 | -0.8528 | -0.8786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8751 | -0.8663 | -0.8708 | -0.8739 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8668 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.41065 | 93.32 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.605 | 0.7297 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8624 | 1.185 | 1.000 | 0.8888 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.163 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.41065</span> | 93.32 | 0.004516 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.605 | 0.7297 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8624 | 1.185 | 1.000 | 0.8888 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.163 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 531.74000 | 0.9993 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8585 | -0.8768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8741 | -0.8674 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8679 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.74 | 93.93 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.601 | 0.7310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8632 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.74</span> | 93.93 | 0.004516 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.601 | 0.7310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8632 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 531.81753 | 0.9999 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8591 | -0.8767 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.81753 | 93.99 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.81753</span> | 93.99 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 531.82573 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8591 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82573 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82573</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 531.82668 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82668 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82668</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 531.82678 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82678 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82678</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 531.82678 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82678 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82678</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 531.82679 | 1.000 | -1.000 | -0.9109 | -0.9296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9779 | -0.8885 | -0.8592 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8740 | -0.8675 | -0.8712 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8680 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 531.82679 | 94.00 | -5.400 | -0.9700 | -1.900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.300 | 0.1400 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 531.82679</span> | 94.00 | 0.004517 | 0.2749 | 0.1496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01357 | 0.5349 | 1.600 | 0.7311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8633 | 1.183 | 1.000 | 0.8891 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.161 |...........|...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># Variance by variable is supported by 'saem' and 'focei'</span></span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_saem_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> 1: 93.4067 -5.7935 -0.0604 2.2993 -1.1624 2.9450 1.7342 0.6650 0.5890 0.4750 14.5215 9.1023</span> -<span class="r-out co"><span class="r-pr">#></span> 2: 93.8811 -5.7873 -0.0289 2.3640 -1.0762 2.7977 2.0710 0.6317 0.5595 0.4512 11.1033 4.6425</span> -<span class="r-out co"><span class="r-pr">#></span> 3: 94.0397 -5.9934 0.0119 2.4035 -1.0703 3.0693 2.4524 0.6124 0.5316 0.4287 10.0698 3.4243</span> -<span class="r-out co"><span class="r-pr">#></span> 4: 93.8834 -6.0401 0.0041 2.3944 -1.0097 2.9159 3.1645 0.6120 0.5050 0.4073 9.2013 3.2162</span> -<span class="r-out co"><span class="r-pr">#></span> 5: 94.0163 -5.8381 -0.0267 2.3580 -1.0239 2.7701 3.0063 0.5814 0.4797 0.3869 9.0330 3.0330</span> -<span class="r-out co"><span class="r-pr">#></span> 6: 93.9753 -5.8371 -0.0315 2.3598 -1.0052 2.6316 2.8559 0.5708 0.4558 0.3675 8.6051 2.6518</span> -<span class="r-out co"><span class="r-pr">#></span> 7: 93.6109 -5.8741 -0.0401 2.3570 -1.0025 2.5000 2.7131 0.5691 0.4330 0.3492 8.4407 2.4701</span> -<span class="r-out co"><span class="r-pr">#></span> 8: 93.2480 -6.0361 -0.0523 2.3504 -1.0028 2.3750 3.1584 0.5407 0.4113 0.3317 8.6121 2.2437</span> -<span class="r-out co"><span class="r-pr">#></span> 9: 93.2245 -6.0431 -0.0503 2.3552 -0.9828 2.2562 3.9790 0.5395 0.3908 0.3151 8.6609 2.1129</span> -<span class="r-out co"><span class="r-pr">#></span> 10: 93.3040 -6.1080 -0.0503 2.3613 -0.9784 2.1434 4.8606 0.5401 0.3712 0.2994 8.6497 2.0865</span> -<span class="r-out co"><span class="r-pr">#></span> 11: 93.4509 -5.9532 -0.0503 2.3444 -0.9823 3.0948 4.6176 0.5679 0.3527 0.2844 8.1651 2.0310</span> -<span class="r-out co"><span class="r-pr">#></span> 12: 93.5099 -6.1699 -0.0503 2.3408 -0.9746 3.2814 4.3867 0.5679 0.3350 0.2702 8.1716 1.9862</span> -<span class="r-out co"><span class="r-pr">#></span> 13: 93.8052 -6.1984 -0.0474 2.3233 -0.9922 3.1173 4.6967 0.5644 0.3183 0.2567 8.2982 2.0040</span> -<span class="r-out co"><span class="r-pr">#></span> 14: 93.6510 -6.0090 -0.0429 2.3601 -0.9885 2.9615 4.4618 0.5526 0.3024 0.2438 8.3254 2.0605</span> -<span class="r-out co"><span class="r-pr">#></span> 15: 93.8952 -6.3354 -0.0394 2.3580 -0.9792 2.8134 5.2117 0.5657 0.2872 0.2316 8.1329 2.0520</span> -<span class="r-out co"><span class="r-pr">#></span> 16: 93.4703 -6.0722 -0.0434 2.3386 -1.0026 2.6727 4.9512 0.5781 0.2729 0.2201 8.0866 2.0994</span> -<span class="r-out co"><span class="r-pr">#></span> 17: 93.4238 -6.2132 -0.0755 2.3120 -1.0119 2.5391 4.7036 0.5495 0.2592 0.2091 7.5958 2.2864</span> -<span class="r-out co"><span class="r-pr">#></span> 18: 93.5288 -6.2747 -0.0616 2.3223 -1.0105 2.4121 4.4684 0.5467 0.2463 0.1986 7.1910 1.9828</span> -<span class="r-out co"><span class="r-pr">#></span> 19: 93.2607 -6.3635 -0.0631 2.3206 -1.0045 3.6271 4.8142 0.5405 0.2340 0.1928 7.3672 1.8187</span> -<span class="r-out co"><span class="r-pr">#></span> 20: 93.3918 -6.3241 -0.0742 2.2941 -1.0140 3.4457 4.9242 0.5596 0.2223 0.1950 7.1427 1.8754</span> -<span class="r-out co"><span class="r-pr">#></span> 21: 93.6794 -6.1336 -0.0758 2.3000 -1.0048 3.2734 4.6780 0.5565 0.2111 0.1852 7.0989 1.9232</span> -<span class="r-out co"><span class="r-pr">#></span> 22: 94.0006 -6.1882 -0.0800 2.3099 -1.0252 3.1098 4.4441 0.5354 0.2006 0.1870 7.0038 1.9920</span> -<span class="r-out co"><span class="r-pr">#></span> 23: 93.6433 -6.2626 -0.0841 2.2791 -1.0183 4.8893 4.4476 0.5276 0.1906 0.1798 6.3698 1.8787</span> -<span class="r-out co"><span class="r-pr">#></span> 24: 93.9545 -6.3772 -0.0816 2.2887 -1.0019 4.6448 5.1698 0.5293 0.1810 0.1779 6.5903 1.9474</span> -<span class="r-out co"><span class="r-pr">#></span> 25: 94.2280 -6.3235 -0.0839 2.2600 -0.9932 5.2801 4.9113 0.5262 0.1720 0.1806 6.5267 1.9807</span> -<span class="r-out co"><span class="r-pr">#></span> 26: 94.2022 -6.2830 -0.0883 2.2643 -1.0012 5.9595 4.6658 0.5225 0.1634 0.1795 6.3678 1.9659</span> -<span class="r-out co"><span class="r-pr">#></span> 27: 94.4398 -6.1769 -0.0894 2.2564 -1.0177 9.0771 4.4325 0.5207 0.1552 0.1880 6.4522 1.8590</span> -<span class="r-out co"><span class="r-pr">#></span> 28: 94.2586 -6.1652 -0.0882 2.2574 -1.0226 8.6233 4.2108 0.5158 0.1475 0.1881 6.3701 1.7882</span> -<span class="r-out co"><span class="r-pr">#></span> 29: 94.3490 -6.1505 -0.0854 2.2615 -1.0081 9.6333 4.0003 0.5109 0.1423 0.1833 6.3601 1.8485</span> -<span class="r-out co"><span class="r-pr">#></span> 30: 94.6929 -6.0285 -0.0909 2.2610 -1.0082 9.1517 3.8003 0.5117 0.1401 0.2097 6.2461 1.8606</span> -<span class="r-out co"><span class="r-pr">#></span> 31: 94.2553 -6.0390 -0.0896 2.2625 -1.0078 8.6941 3.6103 0.5072 0.1378 0.2088 6.3337 1.8220</span> -<span class="r-out co"><span class="r-pr">#></span> 32: 94.3096 -5.7252 -0.0886 2.2677 -0.9967 9.0244 3.4298 0.5051 0.1325 0.2015 6.4601 1.8880</span> -<span class="r-out co"><span class="r-pr">#></span> 33: 94.8327 -5.8775 -0.0865 2.2684 -0.9976 8.6305 3.2583 0.4920 0.1333 0.1993 6.4804 1.8203</span> -<span class="r-out co"><span class="r-pr">#></span> 34: 94.3527 -5.9488 -0.0826 2.2879 -0.9989 8.1989 3.1538 0.4969 0.1388 0.1984 6.4201 1.7696</span> -<span class="r-out co"><span class="r-pr">#></span> 35: 94.4411 -6.1171 -0.0826 2.2913 -0.9964 8.4377 3.7937 0.4969 0.1387 0.1972 6.3878 1.7612</span> -<span class="r-out co"><span class="r-pr">#></span> 36: 94.2058 -6.1151 -0.0844 2.2920 -1.0069 8.0158 3.7963 0.4962 0.1395 0.1938 6.2469 1.6680</span> -<span class="r-out co"><span class="r-pr">#></span> 37: 93.7449 -6.1251 -0.0925 2.2736 -1.0019 7.6150 3.8477 0.5101 0.1325 0.1841 6.1375 1.7472</span> -<span class="r-out co"><span class="r-pr">#></span> 38: 93.6861 -6.0575 -0.0934 2.2803 -1.0097 7.2343 3.6553 0.5119 0.1259 0.1862 6.0729 1.7608</span> -<span class="r-out co"><span class="r-pr">#></span> 39: 93.9767 -6.0314 -0.0999 2.2548 -1.0231 6.8726 3.4725 0.5195 0.1234 0.1951 6.1947 1.8276</span> -<span class="r-out co"><span class="r-pr">#></span> 40: 94.0297 -6.1559 -0.0989 2.2440 -1.0374 6.5290 3.8559 0.5199 0.1279 0.1891 6.0195 1.8906</span> -<span class="r-out co"><span class="r-pr">#></span> 41: 94.2069 -6.3055 -0.0820 2.2710 -1.0275 6.2025 4.7866 0.5304 0.1215 0.1858 6.1777 1.8541</span> -<span class="r-out co"><span class="r-pr">#></span> 42: 94.2400 -6.3179 -0.0790 2.2783 -1.0379 5.8924 4.6915 0.5253 0.1154 0.1794 6.0530 1.8960</span> -<span class="r-out co"><span class="r-pr">#></span> 43: 93.9851 -6.4096 -0.0784 2.2832 -1.0341 5.5978 5.0608 0.5163 0.1097 0.1773 6.0057 1.8136</span> -<span class="r-out co"><span class="r-pr">#></span> 44: 94.1440 -6.2214 -0.0746 2.2969 -1.0262 5.3179 4.8077 0.5130 0.1079 0.1851 6.1182 1.8390</span> -<span class="r-out co"><span class="r-pr">#></span> 45: 93.8847 -6.3883 -0.0745 2.3059 -1.0132 6.8202 5.1378 0.5130 0.1174 0.1769 6.1000 1.8391</span> -<span class="r-out co"><span class="r-pr">#></span> 46: 93.7228 -6.3305 -0.0794 2.3033 -1.0107 6.4792 4.8809 0.5095 0.1196 0.1783 6.2794 1.7304</span> -<span class="r-out co"><span class="r-pr">#></span> 47: 93.7031 -6.4232 -0.0796 2.3006 -1.0028 6.1552 5.5756 0.5092 0.1243 0.1887 6.1716 1.7279</span> -<span class="r-out co"><span class="r-pr">#></span> 48: 93.5210 -6.2770 -0.0794 2.2948 -1.0122 5.8475 5.2968 0.5098 0.1247 0.1863 5.9847 1.7994</span> -<span class="r-out co"><span class="r-pr">#></span> 49: 93.3676 -6.4486 -0.0754 2.3079 -1.0061 5.5551 5.4356 0.5018 0.1198 0.1858 6.1108 1.7598</span> -<span class="r-out co"><span class="r-pr">#></span> 50: 93.8573 -6.3944 -0.0755 2.3057 -1.0038 5.2773 5.2487 0.5063 0.1193 0.1843 6.0935 1.7725</span> -<span class="r-out co"><span class="r-pr">#></span> 51: 93.7004 -6.2783 -0.0854 2.2836 -1.0074 5.0135 4.9863 0.4932 0.1269 0.1858 6.1630 1.8063</span> -<span class="r-out co"><span class="r-pr">#></span> 52: 93.4843 -6.3763 -0.0962 2.2731 -1.0073 4.7628 5.0969 0.4815 0.1345 0.1924 6.0823 1.8013</span> -<span class="r-out co"><span class="r-pr">#></span> 53: 93.6971 -6.5002 -0.0887 2.2774 -1.0111 4.5246 5.7428 0.4726 0.1346 0.1982 6.1744 1.7695</span> -<span class="r-out co"><span class="r-pr">#></span> 54: 93.6176 -6.4928 -0.0917 2.2648 -1.0220 4.2984 5.4557 0.4765 0.1419 0.2017 6.3732 1.8195</span> -<span class="r-out co"><span class="r-pr">#></span> 55: 93.7072 -6.5760 -0.0833 2.2865 -1.0282 4.0835 5.9775 0.4732 0.1434 0.1963 6.3653 1.7028</span> -<span class="r-out co"><span class="r-pr">#></span> 56: 94.1360 -6.6854 -0.0901 2.2941 -1.0244 3.8793 7.2562 0.4637 0.1393 0.1935 6.3001 1.7878</span> -<span class="r-out co"><span class="r-pr">#></span> 57: 93.4627 -6.6255 -0.1049 2.2502 -1.0233 3.6854 6.8934 0.4847 0.1323 0.1878 6.2357 1.8480</span> -<span class="r-out co"><span class="r-pr">#></span> 58: 93.8066 -6.6603 -0.1049 2.2362 -1.0280 3.5011 6.9334 0.4847 0.1397 0.1872 6.3582 1.7787</span> -<span class="r-out co"><span class="r-pr">#></span> 59: 93.8599 -6.7837 -0.1046 2.2450 -1.0274 3.3260 8.4672 0.4853 0.1332 0.1833 6.1248 1.8066</span> -<span class="r-out co"><span class="r-pr">#></span> 60: 93.6190 -6.5618 -0.1055 2.2381 -1.0244 3.1597 8.0438 0.4742 0.1390 0.1858 6.2589 1.7881</span> -<span class="r-out co"><span class="r-pr">#></span> 61: 93.7045 -6.6482 -0.1159 2.2413 -1.0272 3.2942 7.8485 0.4655 0.1406 0.1827 5.8425 1.7744</span> -<span class="r-out co"><span class="r-pr">#></span> 62: 93.5232 -6.5027 -0.1168 2.2418 -1.0187 3.3810 7.4560 0.4766 0.1414 0.1790 5.9349 1.7717</span> -<span class="r-out co"><span class="r-pr">#></span> 63: 93.4884 -6.4221 -0.1164 2.2505 -1.0062 3.2119 7.0832 0.4768 0.1422 0.1752 6.0193 1.7434</span> -<span class="r-out co"><span class="r-pr">#></span> 64: 93.2305 -6.4456 -0.1153 2.2573 -1.0062 4.1468 6.7291 0.4776 0.1395 0.1753 5.8355 1.7529</span> -<span class="r-out co"><span class="r-pr">#></span> 65: 93.3743 -6.3237 -0.1227 2.2484 -1.0102 3.9395 6.3926 0.4864 0.1374 0.1800 5.6731 1.7808</span> -<span class="r-out co"><span class="r-pr">#></span> 66: 93.7132 -6.3178 -0.1186 2.2389 -0.9894 4.0557 6.0730 0.4909 0.1426 0.1807 5.7099 1.7283</span> -<span class="r-out co"><span class="r-pr">#></span> 67: 93.7490 -6.3514 -0.1155 2.2445 -0.9946 3.8529 5.7693 0.4938 0.1379 0.1830 5.7366 1.7847</span> -<span class="r-out co"><span class="r-pr">#></span> 68: 93.7617 -6.1181 -0.1251 2.2487 -0.9841 3.7650 5.4809 0.4816 0.1549 0.1769 5.6569 1.7415</span> -<span class="r-out co"><span class="r-pr">#></span> 69: 93.4342 -6.3588 -0.1301 2.2350 -0.9813 4.5688 5.2068 0.4745 0.1624 0.1736 5.5771 1.7091</span> -<span class="r-out co"><span class="r-pr">#></span> 70: 93.5303 -6.3266 -0.1330 2.2384 -0.9753 4.3404 4.9465 0.4734 0.1563 0.1699 5.5332 1.7256</span> -<span class="r-out co"><span class="r-pr">#></span> 71: 93.4733 -6.2859 -0.1364 2.2170 -0.9781 4.1234 4.6992 0.4701 0.1604 0.1649 5.6661 1.7335</span> -<span class="r-out co"><span class="r-pr">#></span> 72: 93.3055 -6.2502 -0.1462 2.2156 -0.9724 3.9172 4.7693 0.4519 0.1607 0.1582 5.4776 1.7679</span> -<span class="r-out co"><span class="r-pr">#></span> 73: 93.3010 -6.6844 -0.1490 2.2262 -0.9777 3.7213 6.9975 0.4426 0.1848 0.1640 5.7066 1.7588</span> -<span class="r-out co"><span class="r-pr">#></span> 74: 93.1104 -6.6720 -0.1484 2.2079 -0.9982 3.5353 6.7811 0.4436 0.1807 0.1732 5.7700 1.7343</span> -<span class="r-out co"><span class="r-pr">#></span> 75: 93.4534 -6.9644 -0.1480 2.2078 -0.9930 3.3585 8.7027 0.4497 0.1717 0.1708 5.5371 1.7098</span> -<span class="r-out co"><span class="r-pr">#></span> 76: 93.5886 -6.3503 -0.1491 2.1958 -0.9884 3.7136 8.2676 0.4509 0.1731 0.1706 5.3943 1.7340</span> -<span class="r-out co"><span class="r-pr">#></span> 77: 93.4345 -6.4976 -0.1531 2.1831 -0.9928 4.5945 7.8542 0.4592 0.1741 0.1703 5.5564 1.7164</span> -<span class="r-out co"><span class="r-pr">#></span> 78: 93.6007 -6.4885 -0.1538 2.1850 -0.9919 4.3647 7.4615 0.4607 0.1803 0.1692 5.4698 1.7354</span> -<span class="r-out co"><span class="r-pr">#></span> 79: 93.2897 -7.0329 -0.1518 2.1935 -0.9863 4.6922 10.9870 0.4569 0.1790 0.1608 5.3799 1.7484</span> -<span class="r-out co"><span class="r-pr">#></span> 80: 93.4130 -6.6634 -0.1531 2.1865 -0.9839 5.4720 10.4377 0.4585 0.1852 0.1543 5.4298 1.7237</span> -<span class="r-out co"><span class="r-pr">#></span> 81: 93.5828 -6.7204 -0.1563 2.1914 -0.9882 5.1984 9.9158 0.4548 0.1973 0.1600 5.4425 1.7741</span> -<span class="r-out co"><span class="r-pr">#></span> 82: 93.4450 -6.7357 -0.1537 2.1964 -0.9958 4.9384 10.1331 0.4577 0.1874 0.1632 5.6874 1.7789</span> -<span class="r-out co"><span class="r-pr">#></span> 83: 93.6109 -6.9249 -0.1493 2.2061 -0.9945 4.6915 11.1537 0.4474 0.1781 0.1686 5.4249 1.7317</span> -<span class="r-out co"><span class="r-pr">#></span> 84: 93.7133 -6.8029 -0.1493 2.2016 -0.9886 4.4569 10.9568 0.4474 0.1715 0.1689 5.5426 1.7227</span> -<span class="r-out co"><span class="r-pr">#></span> 85: 93.8040 -6.6434 -0.1483 2.2032 -0.9861 5.4991 10.4090 0.4330 0.1749 0.1726 5.4570 1.7332</span> -<span class="r-out co"><span class="r-pr">#></span> 86: 93.9029 -6.7750 -0.1472 2.2066 -0.9892 5.2241 11.7325 0.4352 0.1819 0.1644 5.5652 1.6802</span> -<span class="r-out co"><span class="r-pr">#></span> 87: 93.8127 -6.7015 -0.1499 2.2019 -0.9891 4.9629 11.1459 0.4292 0.1977 0.1661 5.7122 1.6713</span> -<span class="r-out co"><span class="r-pr">#></span> 88: 93.6777 -6.7044 -0.1440 2.2074 -1.0050 4.7148 10.5886 0.4379 0.1878 0.1750 5.6084 1.7096</span> -<span class="r-out co"><span class="r-pr">#></span> 89: 94.0481 -6.2990 -0.1443 2.2085 -0.9869 4.4790 10.0591 0.4355 0.1951 0.1688 5.4280 1.8093</span> -<span class="r-out co"><span class="r-pr">#></span> 90: 93.6399 -6.3965 -0.1429 2.2138 -0.9737 5.1306 9.5562 0.4367 0.1917 0.1604 5.5652 1.7458</span> -<span class="r-out co"><span class="r-pr">#></span> 91: 93.8670 -6.3075 -0.1426 2.2128 -0.9856 5.1368 9.0784 0.4427 0.1993 0.1546 5.3927 1.8246</span> -<span class="r-out co"><span class="r-pr">#></span> 92: 93.7332 -6.4793 -0.1426 2.2091 -0.9835 5.0102 8.6245 0.4427 0.1986 0.1585 5.4463 1.7343</span> -<span class="r-out co"><span class="r-pr">#></span> 93: 93.8211 -6.3270 -0.1416 2.2123 -0.9941 4.7597 8.1932 0.4431 0.1908 0.1689 5.5213 1.7093</span> -<span class="r-out co"><span class="r-pr">#></span> 94: 93.7499 -6.0880 -0.1390 2.2158 -0.9960 5.1992 7.7836 0.4444 0.1958 0.1733 5.5329 1.7880</span> -<span class="r-out co"><span class="r-pr">#></span> 95: 93.6253 -6.2196 -0.1436 2.2126 -1.0053 4.9392 7.3944 0.4383 0.2011 0.1717 5.6042 1.7460</span> -<span class="r-out co"><span class="r-pr">#></span> 96: 93.8862 -6.1475 -0.1408 2.2211 -0.9922 4.6923 7.0247 0.4347 0.2077 0.1669 5.6807 1.6943</span> -<span class="r-out co"><span class="r-pr">#></span> 97: 93.7610 -6.2409 -0.1368 2.2281 -0.9864 4.4576 6.6734 0.4313 0.2084 0.1723 5.5387 1.7075</span> -<span class="r-out co"><span class="r-pr">#></span> 98: 93.5362 -6.3378 -0.1368 2.2294 -0.9813 4.2348 6.3398 0.4313 0.2127 0.1877 5.5850 1.6627</span> -<span class="r-out co"><span class="r-pr">#></span> 99: 93.5044 -6.2557 -0.1311 2.2282 -0.9993 4.0230 6.0228 0.4461 0.2167 0.1879 5.6437 1.7076</span> -<span class="r-out co"><span class="r-pr">#></span> 100: 93.3102 -6.3602 -0.1311 2.2368 -1.0040 3.8219 5.7216 0.4461 0.2139 0.1875 5.8029 1.7592</span> -<span class="r-out co"><span class="r-pr">#></span> 101: 93.4687 -6.0385 -0.1241 2.2347 -1.0031 3.6308 5.4356 0.4483 0.2035 0.1816 6.0097 1.7002</span> -<span class="r-out co"><span class="r-pr">#></span> 102: 93.6536 -6.2867 -0.1299 2.2421 -1.0002 3.4492 5.1743 0.4434 0.1993 0.1872 5.8540 1.7162</span> -<span class="r-out co"><span class="r-pr">#></span> 103: 93.9532 -6.2261 -0.1277 2.2361 -0.9931 3.2768 5.0546 0.4450 0.2069 0.1884 5.6688 1.7324</span> -<span class="r-out co"><span class="r-pr">#></span> 104: 93.9839 -6.1980 -0.1287 2.2286 -1.0081 3.1129 5.0671 0.4475 0.1997 0.1985 5.7690 1.7636</span> -<span class="r-out co"><span class="r-pr">#></span> 105: 94.1682 -6.1671 -0.1283 2.2217 -1.0154 2.9573 4.8137 0.4481 0.1976 0.1965 5.9277 1.7386</span> -<span class="r-out co"><span class="r-pr">#></span> 106: 94.2778 -6.1839 -0.1243 2.2323 -1.0022 3.5381 4.5730 0.4707 0.1980 0.1932 5.7059 1.7184</span> -<span class="r-out co"><span class="r-pr">#></span> 107: 94.3667 -5.9941 -0.1182 2.2283 -1.0191 3.3612 4.3444 0.4753 0.1984 0.1986 5.7813 1.7446</span> -<span class="r-out co"><span class="r-pr">#></span> 108: 94.2722 -6.1869 -0.1171 2.2293 -1.0027 3.6659 4.6329 0.4742 0.1986 0.2011 5.7827 1.7074</span> -<span class="r-out co"><span class="r-pr">#></span> 109: 94.1997 -6.2385 -0.1172 2.2241 -1.0083 3.4826 4.7954 0.4721 0.2027 0.2020 5.8339 1.7650</span> -<span class="r-out co"><span class="r-pr">#></span> 110: 94.3017 -6.3774 -0.1291 2.2229 -0.9857 3.7634 5.8516 0.4810 0.2126 0.1984 5.7961 1.6706</span> -<span class="r-out co"><span class="r-pr">#></span> 111: 93.9803 -6.0240 -0.1258 2.2273 -0.9879 3.5752 5.5590 0.4749 0.2060 0.1976 5.6243 1.7082</span> -<span class="r-out co"><span class="r-pr">#></span> 112: 94.1307 -6.0036 -0.1253 2.2365 -0.9886 4.0368 5.2810 0.4760 0.2060 0.1975 5.5732 1.7063</span> -<span class="r-out co"><span class="r-pr">#></span> 113: 93.8676 -6.2496 -0.1118 2.2600 -1.0080 3.8350 5.0170 0.4855 0.2109 0.2006 5.6406 1.7357</span> -<span class="r-out co"><span class="r-pr">#></span> 114: 93.5949 -6.3200 -0.1044 2.2449 -1.0172 3.6472 4.7661 0.4868 0.2095 0.2131 5.7690 1.7428</span> -<span class="r-out co"><span class="r-pr">#></span> 115: 93.6997 -6.3282 -0.1046 2.2567 -1.0135 3.4648 4.8622 0.4876 0.2264 0.2134 5.8853 1.7823</span> -<span class="r-out co"><span class="r-pr">#></span> 116: 93.8191 -6.0802 -0.1087 2.2535 -1.0011 3.4347 4.6191 0.4786 0.2176 0.2108 5.6553 1.7802</span> -<span class="r-out co"><span class="r-pr">#></span> 117: 93.8575 -6.0930 -0.1022 2.2498 -0.9898 3.3071 4.3881 0.4822 0.2163 0.2075 5.7806 1.8150</span> -<span class="r-out co"><span class="r-pr">#></span> 118: 93.9164 -5.9787 -0.1133 2.2535 -0.9861 4.2578 4.1687 0.4687 0.2198 0.2088 5.4441 1.8411</span> -<span class="r-out co"><span class="r-pr">#></span> 119: 93.8748 -6.0108 -0.1165 2.2488 -0.9775 4.0449 3.9603 0.4653 0.2271 0.2032 5.6119 1.7501</span> -<span class="r-out co"><span class="r-pr">#></span> 120: 93.6001 -6.0447 -0.1144 2.2477 -0.9821 3.8426 3.7623 0.4641 0.2223 0.2055 5.6454 1.7244</span> -<span class="r-out co"><span class="r-pr">#></span> 121: 93.6712 -5.9851 -0.1195 2.2484 -0.9917 3.6505 3.5742 0.4600 0.2143 0.2010 5.4083 1.7965</span> -<span class="r-out co"><span class="r-pr">#></span> 122: 93.6859 -6.0390 -0.1145 2.2497 -0.9888 3.4680 3.5595 0.4618 0.2136 0.1986 5.4111 1.7519</span> -<span class="r-out co"><span class="r-pr">#></span> 123: 93.6014 -5.8383 -0.1145 2.2584 -0.9893 3.6047 3.3815 0.4618 0.2155 0.2045 5.3624 1.7023</span> -<span class="r-out co"><span class="r-pr">#></span> 124: 93.6333 -5.7861 -0.1131 2.2556 -0.9872 3.4245 3.2125 0.4621 0.2153 0.2025 5.3930 1.7036</span> -<span class="r-out co"><span class="r-pr">#></span> 125: 93.4504 -5.9483 -0.1154 2.2531 -0.9924 3.2533 3.0518 0.4640 0.2175 0.2030 5.5097 1.6830</span> -<span class="r-out co"><span class="r-pr">#></span> 126: 93.5693 -5.8818 -0.1120 2.2506 -0.9960 3.0906 2.8992 0.4606 0.2267 0.2016 5.4583 1.6650</span> -<span class="r-out co"><span class="r-pr">#></span> 127: 93.7074 -5.8191 -0.1178 2.2412 -0.9891 2.9361 2.7543 0.4688 0.2234 0.2039 5.4861 1.8125</span> -<span class="r-out co"><span class="r-pr">#></span> 128: 93.5959 -5.8842 -0.1179 2.2544 -0.9985 3.0224 2.6166 0.4700 0.2237 0.2019 5.6417 1.8454</span> -<span class="r-out co"><span class="r-pr">#></span> 129: 93.5600 -5.8683 -0.1161 2.2365 -0.9987 3.4186 2.4857 0.4721 0.2182 0.1918 5.4391 1.8145</span> -<span class="r-out co"><span class="r-pr">#></span> 130: 93.4104 -5.8226 -0.1126 2.2355 -0.9892 3.3648 2.4231 0.4763 0.2212 0.1873 5.3999 1.7457</span> -<span class="r-out co"><span class="r-pr">#></span> 131: 93.5045 -5.7255 -0.1118 2.2486 -0.9918 4.1951 2.3020 0.4776 0.2121 0.1927 5.4342 1.7744</span> -<span class="r-out co"><span class="r-pr">#></span> 132: 93.2626 -5.8379 -0.1097 2.2510 -0.9933 3.9853 2.5572 0.4763 0.2114 0.1966 5.2979 1.7239</span> -<span class="r-out co"><span class="r-pr">#></span> 133: 93.4370 -5.9097 -0.1049 2.2578 -0.9939 4.2190 2.8246 0.4738 0.2036 0.2020 5.2853 1.6765</span> -<span class="r-out co"><span class="r-pr">#></span> 134: 93.8665 -5.9439 -0.1035 2.2654 -0.9832 4.0081 3.1228 0.4756 0.2102 0.1961 5.3467 1.7177</span> -<span class="r-out co"><span class="r-pr">#></span> 135: 93.6301 -5.8062 -0.1031 2.2702 -0.9737 3.9024 2.9667 0.4748 0.2101 0.2003 5.3053 1.6977</span> -<span class="r-out co"><span class="r-pr">#></span> 136: 93.7744 -5.9328 -0.1055 2.2685 -0.9764 3.7072 2.9952 0.4721 0.2096 0.1949 5.4319 1.6864</span> -<span class="r-out co"><span class="r-pr">#></span> 137: 93.6734 -5.9886 -0.1107 2.2517 -0.9732 3.8811 3.4962 0.4642 0.2204 0.1924 5.4294 1.6684</span> -<span class="r-out co"><span class="r-pr">#></span> 138: 93.7128 -5.9927 -0.1119 2.2517 -0.9775 3.6870 3.4543 0.4667 0.2204 0.1953 5.3912 1.7060</span> -<span class="r-out co"><span class="r-pr">#></span> 139: 93.6530 -6.1296 -0.1210 2.2456 -0.9929 3.5027 4.6472 0.4527 0.2296 0.1855 5.4953 1.7242</span> -<span class="r-out co"><span class="r-pr">#></span> 140: 93.9344 -6.2519 -0.1384 2.2304 -0.9970 3.6814 4.4707 0.4337 0.2182 0.1762 5.5643 1.7596</span> -<span class="r-out co"><span class="r-pr">#></span> 141: 93.7356 -6.2804 -0.1296 2.2549 -0.9921 3.9811 4.4876 0.4218 0.2361 0.1674 5.3531 1.7175</span> -<span class="r-out co"><span class="r-pr">#></span> 142: 93.7399 -6.0023 -0.1098 2.2611 -0.9815 3.7821 4.2632 0.4395 0.2421 0.1807 5.3139 1.7191</span> -<span class="r-out co"><span class="r-pr">#></span> 143: 93.4732 -6.0376 -0.1108 2.2689 -0.9734 3.5930 4.0500 0.4396 0.2541 0.1718 5.2930 1.6229</span> -<span class="r-out co"><span class="r-pr">#></span> 144: 93.4900 -5.9517 -0.1093 2.2876 -0.9675 3.4133 3.8475 0.4337 0.2542 0.1711 5.4258 1.5660</span> -<span class="r-out co"><span class="r-pr">#></span> 145: 93.4090 -5.9596 -0.1000 2.2942 -0.9756 3.2426 3.6551 0.4274 0.2422 0.1671 5.3539 1.6971</span> -<span class="r-out co"><span class="r-pr">#></span> 146: 93.4142 -5.9549 -0.0982 2.2846 -0.9704 3.0805 3.6092 0.4226 0.2339 0.1745 5.5092 1.6696</span> -<span class="r-out co"><span class="r-pr">#></span> 147: 93.4409 -6.0720 -0.0971 2.2942 -0.9891 2.9265 3.9922 0.4224 0.2373 0.1781 5.5599 1.6080</span> -<span class="r-out co"><span class="r-pr">#></span> 148: 93.4504 -6.2201 -0.0980 2.2855 -0.9832 2.7802 4.6985 0.4104 0.2464 0.1856 5.5016 1.5877</span> -<span class="r-out co"><span class="r-pr">#></span> 149: 93.4240 -6.2122 -0.1005 2.2728 -0.9881 3.7659 4.7755 0.4082 0.2642 0.1885 5.4942 1.5534</span> -<span class="r-out co"><span class="r-pr">#></span> 150: 93.5094 -6.1295 -0.1087 2.2717 -0.9941 3.5776 4.5367 0.4109 0.2611 0.1928 5.3468 1.5585</span> -<span class="r-out co"><span class="r-pr">#></span> 151: 93.4038 -6.2751 -0.1130 2.2643 -0.9892 3.3987 4.9866 0.4172 0.2638 0.1905 5.4955 1.6256</span> -<span class="r-out co"><span class="r-pr">#></span> 152: 93.5072 -6.3361 -0.1147 2.2627 -0.9988 2.3580 5.3824 0.4175 0.2656 0.1819 5.7685 1.6126</span> -<span class="r-out co"><span class="r-pr">#></span> 153: 93.3582 -6.2019 -0.1227 2.2526 -0.9929 2.5874 4.7052 0.4348 0.2621 0.1810 5.5149 1.6181</span> -<span class="r-out co"><span class="r-pr">#></span> 154: 93.1890 -6.3537 -0.1263 2.2446 -0.9871 2.4073 5.7070 0.4351 0.2586 0.1829 5.3136 1.6272</span> -<span class="r-out co"><span class="r-pr">#></span> 155: 93.1706 -6.4117 -0.1260 2.2484 -0.9845 2.3035 6.0004 0.4463 0.2586 0.1781 5.4260 1.6494</span> -<span class="r-out co"><span class="r-pr">#></span> 156: 93.3240 -6.3931 -0.1259 2.2469 -0.9824 2.5659 5.7375 0.4466 0.2781 0.1754 5.6202 1.6591</span> -<span class="r-out co"><span class="r-pr">#></span> 157: 93.3239 -6.1812 -0.1242 2.2541 -0.9743 1.6054 4.5906 0.4478 0.2657 0.1758 5.6806 1.6367</span> -<span class="r-out co"><span class="r-pr">#></span> 158: 93.3756 -6.2562 -0.1264 2.2706 -0.9888 1.5329 4.6790 0.4458 0.2532 0.1728 5.7756 1.6248</span> -<span class="r-out co"><span class="r-pr">#></span> 159: 93.3034 -6.3291 -0.1217 2.2524 -0.9954 1.7774 5.7204 0.4532 0.2642 0.1715 5.8189 1.6830</span> -<span class="r-out co"><span class="r-pr">#></span> 160: 93.4387 -6.5115 -0.1196 2.2488 -0.9846 2.2219 6.4960 0.4555 0.2728 0.1689 5.5273 1.6332</span> -<span class="r-out co"><span class="r-pr">#></span> 161: 93.7646 -6.3820 -0.1231 2.2520 -0.9837 2.8322 5.7269 0.4498 0.2712 0.1730 5.3659 1.5787</span> -<span class="r-out co"><span class="r-pr">#></span> 162: 93.6252 -6.4563 -0.1243 2.2472 -0.9867 2.8322 5.9119 0.4502 0.2671 0.1726 5.4519 1.5819</span> -<span class="r-out co"><span class="r-pr">#></span> 163: 93.6787 -6.6444 -0.1292 2.2366 -0.9899 2.0520 7.4835 0.4556 0.2705 0.1689 5.4095 1.5883</span> -<span class="r-out co"><span class="r-pr">#></span> 164: 93.7458 -6.9330 -0.1257 2.2430 -0.9872 1.7825 9.4340 0.4495 0.2701 0.1593 5.4517 1.6116</span> -<span class="r-out co"><span class="r-pr">#></span> 165: 93.7370 -6.9118 -0.1250 2.2421 -0.9832 1.9949 10.6549 0.4499 0.2685 0.1622 5.6272 1.6075</span> -<span class="r-out co"><span class="r-pr">#></span> 166: 94.0889 -6.8704 -0.1276 2.2409 -0.9872 1.5618 10.4435 0.4482 0.2608 0.1648 5.5891 1.6208</span> -<span class="r-out co"><span class="r-pr">#></span> 167: 94.1319 -7.2779 -0.1206 2.2505 -0.9894 1.5063 13.4312 0.4393 0.2549 0.1661 5.6013 1.6043</span> -<span class="r-out co"><span class="r-pr">#></span> 168: 93.8341 -6.9310 -0.1140 2.2495 -0.9844 1.7329 11.3224 0.4463 0.2540 0.1629 5.8366 1.6765</span> -<span class="r-out co"><span class="r-pr">#></span> 169: 93.8923 -6.6547 -0.1173 2.2620 -0.9872 1.4531 8.4608 0.4419 0.2414 0.1666 5.8784 1.6268</span> -<span class="r-out co"><span class="r-pr">#></span> 170: 94.0072 -6.3970 -0.1173 2.2606 -0.9861 1.4164 6.9237 0.4419 0.2468 0.1656 5.8793 1.6387</span> -<span class="r-out co"><span class="r-pr">#></span> 171: 93.8690 -6.5151 -0.1079 2.2482 -0.9880 1.9225 7.7681 0.4547 0.2404 0.1523 6.0158 1.6281</span> -<span class="r-out co"><span class="r-pr">#></span> 172: 93.6847 -6.3416 -0.1095 2.2438 -0.9849 2.0143 5.5739 0.4498 0.2450 0.1534 6.1355 1.6422</span> -<span class="r-out co"><span class="r-pr">#></span> 173: 93.4817 -6.3165 -0.1115 2.2573 -0.9885 1.6855 5.5626 0.4440 0.2471 0.1542 6.1343 1.6337</span> -<span class="r-out co"><span class="r-pr">#></span> 174: 93.6781 -6.2722 -0.1113 2.2521 -0.9958 1.9186 5.3383 0.4471 0.2427 0.1565 6.1081 1.6358</span> -<span class="r-out co"><span class="r-pr">#></span> 175: 93.7764 -6.1664 -0.1113 2.2468 -0.9864 1.6286 4.6233 0.4471 0.2426 0.1596 5.8892 1.6375</span> -<span class="r-out co"><span class="r-pr">#></span> 176: 93.9246 -6.2164 -0.1160 2.2529 -0.9853 1.0357 4.8013 0.4422 0.2471 0.1756 5.7340 1.6016</span> -<span class="r-out co"><span class="r-pr">#></span> 177: 93.9711 -6.1274 -0.1112 2.2540 -0.9883 1.2079 4.1536 0.4415 0.2492 0.1783 5.8399 1.6291</span> -<span class="r-out co"><span class="r-pr">#></span> 178: 93.9212 -6.0532 -0.1116 2.2593 -0.9742 1.2409 3.6443 0.4489 0.2458 0.1683 5.8422 1.6290</span> -<span class="r-out co"><span class="r-pr">#></span> 179: 94.0137 -6.0739 -0.1095 2.2664 -0.9778 1.5060 3.9878 0.4506 0.2370 0.1746 6.0349 1.6326</span> -<span class="r-out co"><span class="r-pr">#></span> 180: 93.9247 -6.0681 -0.1130 2.2660 -0.9934 1.9619 3.9582 0.4474 0.2328 0.1773 5.8082 1.6740</span> -<span class="r-out co"><span class="r-pr">#></span> 181: 93.7150 -6.0191 -0.1153 2.2558 -0.9915 2.6849 3.7075 0.4491 0.2283 0.1759 5.7187 1.6842</span> -<span class="r-out co"><span class="r-pr">#></span> 182: 93.5908 -6.1098 -0.1111 2.2769 -0.9942 3.0096 3.9325 0.4643 0.2275 0.1736 5.9243 1.6466</span> -<span class="r-out co"><span class="r-pr">#></span> 183: 93.3386 -6.0987 -0.1131 2.2630 -0.9962 3.5457 4.1285 0.4693 0.2373 0.1751 5.6948 1.7222</span> -<span class="r-out co"><span class="r-pr">#></span> 184: 93.4889 -6.3097 -0.1134 2.2660 -0.9720 3.0855 5.2642 0.4648 0.2255 0.1585 5.6827 1.7444</span> -<span class="r-out co"><span class="r-pr">#></span> 185: 93.6387 -6.1883 -0.1188 2.2622 -0.9603 3.3568 4.8291 0.4554 0.2223 0.1681 5.7089 1.8164</span> -<span class="r-out co"><span class="r-pr">#></span> 186: 93.3420 -6.2909 -0.1195 2.2656 -0.9835 3.2124 4.8317 0.4541 0.2286 0.1531 5.7574 1.7708</span> -<span class="r-out co"><span class="r-pr">#></span> 187: 93.4395 -6.0358 -0.1165 2.2528 -0.9917 3.8299 3.3301 0.4518 0.2370 0.1593 5.8508 1.6988</span> -<span class="r-out co"><span class="r-pr">#></span> 188: 93.5358 -6.0105 -0.1161 2.2540 -0.9813 5.1249 3.3448 0.4522 0.2361 0.1660 5.8700 1.6525</span> -<span class="r-out co"><span class="r-pr">#></span> 189: 93.4932 -6.1199 -0.1129 2.2636 -0.9812 4.5430 4.3213 0.4428 0.2359 0.1907 5.6970 1.7268</span> -<span class="r-out co"><span class="r-pr">#></span> 190: 93.4754 -5.9088 -0.1171 2.2564 -0.9614 4.6253 3.2590 0.4410 0.2399 0.1864 5.7116 1.8140</span> -<span class="r-out co"><span class="r-pr">#></span> 191: 93.4709 -5.9676 -0.1171 2.2568 -0.9748 4.8326 3.6704 0.4410 0.2428 0.1812 5.5925 1.7267</span> -<span class="r-out co"><span class="r-pr">#></span> 192: 93.3895 -5.9940 -0.1191 2.2523 -0.9691 4.3019 3.5174 0.4360 0.2484 0.1591 5.4631 1.7057</span> -<span class="r-out co"><span class="r-pr">#></span> 193: 93.4904 -6.0400 -0.1173 2.2519 -0.9697 4.6476 3.6255 0.4389 0.2388 0.1694 5.5362 1.7174</span> -<span class="r-out co"><span class="r-pr">#></span> 194: 93.4591 -5.9642 -0.1245 2.2626 -0.9559 5.3125 3.8133 0.4297 0.2550 0.1660 5.7591 1.7344</span> -<span class="r-out co"><span class="r-pr">#></span> 195: 93.6610 -6.2211 -0.1226 2.2580 -0.9669 5.2051 4.9271 0.4318 0.2414 0.1811 5.7010 1.7710</span> -<span class="r-out co"><span class="r-pr">#></span> 196: 93.4249 -5.9570 -0.1068 2.2735 -0.9727 5.1049 3.4872 0.4442 0.2429 0.1815 5.7753 1.7379</span> -<span class="r-out co"><span class="r-pr">#></span> 197: 93.4082 -6.0568 -0.1054 2.2754 -0.9865 5.2827 3.9305 0.4554 0.2408 0.1925 5.7514 1.7163</span> -<span class="r-out co"><span class="r-pr">#></span> 198: 93.3856 -5.8616 -0.1087 2.2708 -0.9686 4.1369 3.0197 0.4530 0.2473 0.1878 5.6920 1.7043</span> -<span class="r-out co"><span class="r-pr">#></span> 199: 93.5488 -6.0494 -0.1167 2.2682 -0.9719 3.8010 3.8897 0.4600 0.2445 0.1860 5.7126 1.6605</span> -<span class="r-out co"><span class="r-pr">#></span> 200: 93.3779 -5.9779 -0.1110 2.2761 -0.9780 3.5955 3.4721 0.4595 0.2468 0.1941 5.7539 1.6736</span> -<span class="r-out co"><span class="r-pr">#></span> 201: 93.4946 -6.0259 -0.1102 2.2676 -0.9755 3.0583 3.7305 0.4592 0.2554 0.1921 5.8877 1.6730</span> -<span class="r-out co"><span class="r-pr">#></span> 202: 93.4698 -6.0522 -0.1110 2.2685 -0.9703 2.9421 3.8718 0.4579 0.2595 0.1906 5.8527 1.6701</span> -<span class="r-out co"><span class="r-pr">#></span> 203: 93.4625 -6.0744 -0.1132 2.2642 -0.9696 3.1854 4.0983 0.4589 0.2596 0.1886 5.7532 1.6655</span> -<span class="r-out co"><span class="r-pr">#></span> 204: 93.4984 -6.0853 -0.1138 2.2589 -0.9718 3.2826 4.1667 0.4581 0.2588 0.1851 5.7274 1.6694</span> -<span class="r-out co"><span class="r-pr">#></span> 205: 93.5279 -6.1054 -0.1151 2.2562 -0.9742 3.3257 4.2680 0.4569 0.2584 0.1832 5.6976 1.6777</span> -<span class="r-out co"><span class="r-pr">#></span> 206: 93.6025 -6.1087 -0.1174 2.2518 -0.9767 3.2399 4.2443 0.4582 0.2589 0.1822 5.6809 1.6775</span> -<span class="r-out co"><span class="r-pr">#></span> 207: 93.6382 -6.0990 -0.1204 2.2481 -0.9801 3.2768 4.1473 0.4579 0.2591 0.1823 5.6460 1.6819</span> -<span class="r-out co"><span class="r-pr">#></span> 208: 93.6250 -6.0878 -0.1224 2.2438 -0.9812 3.1815 4.0872 0.4579 0.2577 0.1818 5.6256 1.6887</span> -<span class="r-out co"><span class="r-pr">#></span> 209: 93.6102 -6.0740 -0.1255 2.2394 -0.9803 3.1716 3.9968 0.4561 0.2573 0.1812 5.6063 1.6886</span> -<span class="r-out co"><span class="r-pr">#></span> 210: 93.6005 -6.0571 -0.1277 2.2348 -0.9799 3.2408 3.8923 0.4548 0.2572 0.1798 5.5849 1.6912</span> -<span class="r-out co"><span class="r-pr">#></span> 211: 93.6270 -6.0425 -0.1306 2.2292 -0.9807 3.3500 3.8267 0.4538 0.2586 0.1792 5.5578 1.6992</span> -<span class="r-out co"><span class="r-pr">#></span> 212: 93.6641 -6.0403 -0.1331 2.2253 -0.9806 3.4487 3.8366 0.4529 0.2596 0.1786 5.5422 1.7022</span> -<span class="r-out co"><span class="r-pr">#></span> 213: 93.6743 -6.0344 -0.1354 2.2214 -0.9800 3.5484 3.8260 0.4518 0.2606 0.1781 5.5250 1.7069</span> -<span class="r-out co"><span class="r-pr">#></span> 214: 93.6719 -6.0405 -0.1377 2.2179 -0.9804 3.5538 3.8785 0.4506 0.2612 0.1769 5.5148 1.7087</span> -<span class="r-out co"><span class="r-pr">#></span> 215: 93.6743 -6.0403 -0.1396 2.2146 -0.9801 3.5578 3.9180 0.4496 0.2615 0.1761 5.5118 1.7094</span> -<span class="r-out co"><span class="r-pr">#></span> 216: 93.6666 -6.0436 -0.1413 2.2115 -0.9796 3.5848 3.9484 0.4488 0.2624 0.1755 5.5015 1.7116</span> -<span class="r-out co"><span class="r-pr">#></span> 217: 93.6715 -6.0438 -0.1430 2.2086 -0.9794 3.6188 3.9603 0.4478 0.2631 0.1748 5.4884 1.7132</span> -<span class="r-out co"><span class="r-pr">#></span> 218: 93.6765 -6.0488 -0.1441 2.2060 -0.9796 3.6126 3.9885 0.4471 0.2632 0.1746 5.4714 1.7156</span> -<span class="r-out co"><span class="r-pr">#></span> 219: 93.6714 -6.0557 -0.1453 2.2038 -0.9798 3.6603 4.0118 0.4463 0.2632 0.1735 5.4593 1.7235</span> -<span class="r-out co"><span class="r-pr">#></span> 220: 93.6728 -6.0711 -0.1462 2.2027 -0.9794 3.7244 4.0910 0.4457 0.2639 0.1730 5.4531 1.7241</span> -<span class="r-out co"><span class="r-pr">#></span> 221: 93.6723 -6.0822 -0.1470 2.2015 -0.9788 3.7754 4.1554 0.4450 0.2647 0.1724 5.4511 1.7247</span> -<span class="r-out co"><span class="r-pr">#></span> 222: 93.6789 -6.0745 -0.1480 2.1998 -0.9780 3.8735 4.1186 0.4442 0.2662 0.1718 5.4419 1.7258</span> -<span class="r-out co"><span class="r-pr">#></span> 223: 93.6891 -6.0700 -0.1488 2.1984 -0.9778 3.9353 4.0998 0.4434 0.2681 0.1715 5.4375 1.7251</span> -<span class="r-out co"><span class="r-pr">#></span> 224: 93.7125 -6.0705 -0.1496 2.1976 -0.9774 4.0220 4.0861 0.4427 0.2697 0.1711 5.4378 1.7230</span> -<span class="r-out co"><span class="r-pr">#></span> 225: 93.7332 -6.0695 -0.1502 2.1966 -0.9775 4.0553 4.0669 0.4422 0.2712 0.1711 5.4355 1.7205</span> -<span class="r-out co"><span class="r-pr">#></span> 226: 93.7631 -6.0712 -0.1508 2.1951 -0.9779 4.0755 4.0572 0.4417 0.2728 0.1712 5.4347 1.7190</span> -<span class="r-out co"><span class="r-pr">#></span> 227: 93.7912 -6.0687 -0.1512 2.1938 -0.9785 4.0621 4.0439 0.4409 0.2742 0.1716 5.4325 1.7189</span> -<span class="r-out co"><span class="r-pr">#></span> 228: 93.8077 -6.0644 -0.1517 2.1927 -0.9791 4.0246 4.0190 0.4400 0.2755 0.1722 5.4269 1.7193</span> -<span class="r-out co"><span class="r-pr">#></span> 229: 93.8255 -6.0661 -0.1521 2.1909 -0.9796 3.9958 4.0166 0.4392 0.2769 0.1725 5.4214 1.7214</span> -<span class="r-out co"><span class="r-pr">#></span> 230: 93.8403 -6.0766 -0.1530 2.1895 -0.9802 4.0152 4.0548 0.4380 0.2788 0.1730 5.4214 1.7232</span> -<span class="r-out co"><span class="r-pr">#></span> 231: 93.8549 -6.0768 -0.1541 2.1877 -0.9810 4.0690 4.0542 0.4368 0.2803 0.1734 5.4157 1.7236</span> -<span class="r-out co"><span class="r-pr">#></span> 232: 93.8666 -6.0728 -0.1550 2.1858 -0.9816 4.0852 4.0337 0.4356 0.2818 0.1736 5.4136 1.7224</span> -<span class="r-out co"><span class="r-pr">#></span> 233: 93.8728 -6.0672 -0.1557 2.1844 -0.9820 4.1001 4.0000 0.4346 0.2828 0.1738 5.4028 1.7243</span> -<span class="r-out co"><span class="r-pr">#></span> 234: 93.8862 -6.0646 -0.1563 2.1830 -0.9825 4.1303 3.9850 0.4337 0.2838 0.1737 5.3924 1.7222</span> -<span class="r-out co"><span class="r-pr">#></span> 235: 93.8862 -6.0632 -0.1570 2.1819 -0.9827 4.1149 3.9735 0.4329 0.2847 0.1737 5.3846 1.7225</span> -<span class="r-out co"><span class="r-pr">#></span> 236: 93.8827 -6.0639 -0.1577 2.1814 -0.9834 4.1004 3.9711 0.4322 0.2852 0.1739 5.3838 1.7220</span> -<span class="r-out co"><span class="r-pr">#></span> 237: 93.8729 -6.0680 -0.1582 2.1808 -0.9840 4.0606 3.9866 0.4316 0.2857 0.1741 5.3806 1.7213</span> -<span class="r-out co"><span class="r-pr">#></span> 238: 93.8739 -6.0733 -0.1587 2.1806 -0.9845 4.0331 4.0011 0.4311 0.2859 0.1742 5.3775 1.7199</span> -<span class="r-out co"><span class="r-pr">#></span> 239: 93.8732 -6.0729 -0.1591 2.1802 -0.9853 3.9850 3.9892 0.4307 0.2859 0.1744 5.3782 1.7216</span> -<span class="r-out co"><span class="r-pr">#></span> 240: 93.8760 -6.0754 -0.1595 2.1796 -0.9854 3.9349 3.9867 0.4303 0.2858 0.1747 5.3781 1.7232</span> -<span class="r-out co"><span class="r-pr">#></span> 241: 93.8779 -6.0749 -0.1599 2.1791 -0.9853 3.9241 3.9801 0.4299 0.2858 0.1748 5.3757 1.7228</span> -<span class="r-out co"><span class="r-pr">#></span> 242: 93.8842 -6.0716 -0.1602 2.1786 -0.9852 3.9394 3.9651 0.4297 0.2859 0.1749 5.3726 1.7224</span> -<span class="r-out co"><span class="r-pr">#></span> 243: 93.8884 -6.0719 -0.1606 2.1778 -0.9851 3.9310 3.9741 0.4295 0.2857 0.1750 5.3705 1.7224</span> -<span class="r-out co"><span class="r-pr">#></span> 244: 93.8910 -6.0712 -0.1610 2.1771 -0.9850 3.9173 3.9819 0.4294 0.2856 0.1749 5.3700 1.7222</span> -<span class="r-out co"><span class="r-pr">#></span> 245: 93.9054 -6.0736 -0.1614 2.1764 -0.9854 3.9106 3.9984 0.4293 0.2856 0.1748 5.3711 1.7217</span> -<span class="r-out co"><span class="r-pr">#></span> 246: 93.9209 -6.0753 -0.1617 2.1757 -0.9859 3.9080 4.0071 0.4291 0.2852 0.1746 5.3711 1.7215</span> -<span class="r-out co"><span class="r-pr">#></span> 247: 93.9273 -6.0846 -0.1621 2.1752 -0.9861 3.8790 4.0580 0.4286 0.2851 0.1745 5.3755 1.7206</span> -<span class="r-out co"><span class="r-pr">#></span> 248: 93.9265 -6.0884 -0.1625 2.1749 -0.9865 3.8613 4.0784 0.4286 0.2848 0.1744 5.3760 1.7198</span> -<span class="r-out co"><span class="r-pr">#></span> 249: 93.9286 -6.0926 -0.1627 2.1746 -0.9872 3.8663 4.1008 0.4287 0.2845 0.1745 5.3755 1.7195</span> -<span class="r-out co"><span class="r-pr">#></span> 250: 93.9287 -6.0968 -0.1629 2.1744 -0.9878 3.8822 4.1269 0.4289 0.2844 0.1743 5.3755 1.7201</span> -<span class="r-out co"><span class="r-pr">#></span> 251: 93.9314 -6.1017 -0.1630 2.1739 -0.9882 3.8878 4.1495 0.4291 0.2843 0.1744 5.3729 1.7200</span> -<span class="r-out co"><span class="r-pr">#></span> 252: 93.9351 -6.1036 -0.1632 2.1734 -0.9885 3.8908 4.1545 0.4293 0.2843 0.1746 5.3684 1.7191</span> -<span class="r-out co"><span class="r-pr">#></span> 253: 93.9415 -6.1053 -0.1634 2.1729 -0.9889 3.8727 4.1602 0.4294 0.2842 0.1747 5.3650 1.7196</span> -<span class="r-out co"><span class="r-pr">#></span> 254: 93.9473 -6.1088 -0.1636 2.1723 -0.9891 3.8657 4.1769 0.4296 0.2843 0.1749 5.3666 1.7190</span> -<span class="r-out co"><span class="r-pr">#></span> 255: 93.9505 -6.1087 -0.1639 2.1717 -0.9888 3.8457 4.1720 0.4298 0.2841 0.1749 5.3617 1.7191</span> -<span class="r-out co"><span class="r-pr">#></span> 256: 93.9497 -6.1054 -0.1642 2.1715 -0.9885 3.8395 4.1559 0.4299 0.2839 0.1749 5.3598 1.7192</span> -<span class="r-out co"><span class="r-pr">#></span> 257: 93.9477 -6.1008 -0.1643 2.1713 -0.9882 3.8383 4.1360 0.4299 0.2836 0.1749 5.3567 1.7196</span> -<span class="r-out co"><span class="r-pr">#></span> 258: 93.9402 -6.0998 -0.1645 2.1713 -0.9880 3.8516 4.1288 0.4300 0.2832 0.1749 5.3565 1.7190</span> -<span class="r-out co"><span class="r-pr">#></span> 259: 93.9318 -6.0979 -0.1646 2.1711 -0.9879 3.8396 4.1182 0.4301 0.2829 0.1750 5.3583 1.7188</span> -<span class="r-out co"><span class="r-pr">#></span> 260: 93.9277 -6.1002 -0.1646 2.1713 -0.9879 3.8173 4.1273 0.4304 0.2826 0.1751 5.3611 1.7186</span> -<span class="r-out co"><span class="r-pr">#></span> 261: 93.9251 -6.0973 -0.1646 2.1714 -0.9879 3.8140 4.1105 0.4306 0.2822 0.1750 5.3588 1.7192</span> -<span class="r-out co"><span class="r-pr">#></span> 262: 93.9186 -6.1009 -0.1647 2.1715 -0.9880 3.8177 4.1303 0.4308 0.2822 0.1750 5.3604 1.7194</span> -<span class="r-out co"><span class="r-pr">#></span> 263: 93.9130 -6.1033 -0.1646 2.1715 -0.9880 3.8029 4.1529 0.4309 0.2822 0.1748 5.3647 1.7188</span> -<span class="r-out co"><span class="r-pr">#></span> 264: 93.9040 -6.1077 -0.1645 2.1717 -0.9879 3.7950 4.1820 0.4310 0.2822 0.1747 5.3699 1.7184</span> -<span class="r-out co"><span class="r-pr">#></span> 265: 93.9012 -6.1071 -0.1645 2.1714 -0.9879 3.7834 4.1895 0.4310 0.2822 0.1746 5.3755 1.7191</span> -<span class="r-out co"><span class="r-pr">#></span> 266: 93.8988 -6.1051 -0.1644 2.1714 -0.9879 3.7788 4.1822 0.4311 0.2822 0.1745 5.3765 1.7203</span> -<span class="r-out co"><span class="r-pr">#></span> 267: 93.8964 -6.1059 -0.1643 2.1714 -0.9877 3.7774 4.1896 0.4311 0.2822 0.1744 5.3792 1.7197</span> -<span class="r-out co"><span class="r-pr">#></span> 268: 93.8901 -6.1092 -0.1643 2.1715 -0.9876 3.7790 4.2198 0.4310 0.2822 0.1742 5.3811 1.7200</span> -<span class="r-out co"><span class="r-pr">#></span> 269: 93.8842 -6.1105 -0.1643 2.1717 -0.9875 3.7620 4.2336 0.4310 0.2823 0.1742 5.3838 1.7193</span> -<span class="r-out co"><span class="r-pr">#></span> 270: 93.8760 -6.1125 -0.1643 2.1721 -0.9874 3.7668 4.2483 0.4308 0.2823 0.1741 5.3852 1.7181</span> -<span class="r-out co"><span class="r-pr">#></span> 271: 93.8705 -6.1149 -0.1643 2.1722 -0.9873 3.7785 4.2625 0.4306 0.2823 0.1742 5.3853 1.7172</span> -<span class="r-out co"><span class="r-pr">#></span> 272: 93.8674 -6.1149 -0.1643 2.1723 -0.9871 3.7829 4.2581 0.4304 0.2823 0.1743 5.3836 1.7162</span> -<span class="r-out co"><span class="r-pr">#></span> 273: 93.8644 -6.1159 -0.1642 2.1725 -0.9870 3.7910 4.2631 0.4303 0.2825 0.1743 5.3818 1.7154</span> -<span class="r-out co"><span class="r-pr">#></span> 274: 93.8585 -6.1158 -0.1640 2.1728 -0.9869 3.7926 4.2612 0.4302 0.2825 0.1743 5.3816 1.7147</span> -<span class="r-out co"><span class="r-pr">#></span> 275: 93.8564 -6.1151 -0.1639 2.1732 -0.9867 3.8053 4.2581 0.4301 0.2826 0.1743 5.3804 1.7143</span> -<span class="r-out co"><span class="r-pr">#></span> 276: 93.8564 -6.1132 -0.1638 2.1736 -0.9866 3.7958 4.2486 0.4300 0.2827 0.1745 5.3810 1.7144</span> -<span class="r-out co"><span class="r-pr">#></span> 277: 93.8564 -6.1120 -0.1637 2.1741 -0.9867 3.7952 4.2426 0.4298 0.2829 0.1747 5.3808 1.7148</span> -<span class="r-out co"><span class="r-pr">#></span> 278: 93.8528 -6.1113 -0.1636 2.1743 -0.9867 3.7922 4.2352 0.4297 0.2832 0.1750 5.3819 1.7144</span> -<span class="r-out co"><span class="r-pr">#></span> 279: 93.8503 -6.1124 -0.1636 2.1744 -0.9867 3.7930 4.2390 0.4298 0.2834 0.1753 5.3826 1.7144</span> -<span class="r-out co"><span class="r-pr">#></span> 280: 93.8466 -6.1146 -0.1636 2.1743 -0.9867 3.7946 4.2470 0.4299 0.2838 0.1755 5.3832 1.7142</span> -<span class="r-out co"><span class="r-pr">#></span> 281: 93.8435 -6.1165 -0.1638 2.1743 -0.9867 3.7994 4.2552 0.4298 0.2840 0.1756 5.3828 1.7140</span> -<span class="r-out co"><span class="r-pr">#></span> 282: 93.8421 -6.1162 -0.1639 2.1741 -0.9868 3.7967 4.2496 0.4296 0.2843 0.1758 5.3816 1.7137</span> -<span class="r-out co"><span class="r-pr">#></span> 283: 93.8382 -6.1146 -0.1641 2.1740 -0.9866 3.7957 4.2387 0.4294 0.2845 0.1760 5.3796 1.7135</span> -<span class="r-out co"><span class="r-pr">#></span> 284: 93.8356 -6.1131 -0.1641 2.1740 -0.9865 3.7904 4.2263 0.4292 0.2848 0.1762 5.3776 1.7127</span> -<span class="r-out co"><span class="r-pr">#></span> 285: 93.8349 -6.1113 -0.1642 2.1740 -0.9865 3.7841 4.2129 0.4291 0.2850 0.1765 5.3763 1.7130</span> -<span class="r-out co"><span class="r-pr">#></span> 286: 93.8372 -6.1095 -0.1643 2.1741 -0.9864 3.7801 4.2035 0.4289 0.2853 0.1769 5.3779 1.7130</span> -<span class="r-out co"><span class="r-pr">#></span> 287: 93.8393 -6.1077 -0.1643 2.1741 -0.9864 3.7804 4.1908 0.4287 0.2857 0.1771 5.3785 1.7132</span> -<span class="r-out co"><span class="r-pr">#></span> 288: 93.8395 -6.1071 -0.1644 2.1740 -0.9866 3.7714 4.1834 0.4284 0.2859 0.1772 5.3798 1.7120</span> -<span class="r-out co"><span class="r-pr">#></span> 289: 93.8398 -6.1065 -0.1645 2.1738 -0.9865 3.7635 4.1765 0.4282 0.2861 0.1774 5.3821 1.7111</span> -<span class="r-out co"><span class="r-pr">#></span> 290: 93.8376 -6.1089 -0.1647 2.1737 -0.9865 3.7495 4.1853 0.4281 0.2863 0.1776 5.3852 1.7106</span> -<span class="r-out co"><span class="r-pr">#></span> 291: 93.8341 -6.1091 -0.1647 2.1738 -0.9863 3.7340 4.1854 0.4278 0.2865 0.1776 5.3868 1.7098</span> -<span class="r-out co"><span class="r-pr">#></span> 292: 93.8329 -6.1080 -0.1647 2.1741 -0.9863 3.7189 4.1760 0.4275 0.2868 0.1777 5.3885 1.7091</span> -<span class="r-out co"><span class="r-pr">#></span> 293: 93.8312 -6.1065 -0.1647 2.1743 -0.9862 3.7091 4.1651 0.4272 0.2871 0.1778 5.3896 1.7086</span> -<span class="r-out co"><span class="r-pr">#></span> 294: 93.8310 -6.1042 -0.1647 2.1745 -0.9861 3.6946 4.1521 0.4269 0.2874 0.1780 5.3908 1.7077</span> -<span class="r-out co"><span class="r-pr">#></span> 295: 93.8299 -6.1033 -0.1648 2.1747 -0.9861 3.6968 4.1433 0.4265 0.2880 0.1781 5.3904 1.7066</span> -<span class="r-out co"><span class="r-pr">#></span> 296: 93.8276 -6.1027 -0.1648 2.1749 -0.9862 3.7072 4.1361 0.4261 0.2885 0.1782 5.3910 1.7056</span> -<span class="r-out co"><span class="r-pr">#></span> 297: 93.8212 -6.1015 -0.1647 2.1750 -0.9859 3.7253 4.1278 0.4256 0.2891 0.1783 5.3927 1.7051</span> -<span class="r-out co"><span class="r-pr">#></span> 298: 93.8173 -6.0980 -0.1647 2.1751 -0.9858 3.7552 4.1115 0.4251 0.2897 0.1784 5.3932 1.7045</span> -<span class="r-out co"><span class="r-pr">#></span> 299: 93.8168 -6.0984 -0.1646 2.1754 -0.9856 3.7687 4.1143 0.4246 0.2902 0.1786 5.3949 1.7037</span> -<span class="r-out co"><span class="r-pr">#></span> 300: 93.8154 -6.0967 -0.1646 2.1756 -0.9855 3.7888 4.1072 0.4241 0.2906 0.1788 5.3962 1.7030</span> -<span class="r-out co"><span class="r-pr">#></span> 301: 93.8129 -6.0946 -0.1646 2.1757 -0.9852 3.8097 4.1006 0.4236 0.2911 0.1791 5.3971 1.7026</span> -<span class="r-out co"><span class="r-pr">#></span> 302: 93.8120 -6.0932 -0.1646 2.1759 -0.9849 3.8403 4.0955 0.4231 0.2917 0.1792 5.3971 1.7021</span> -<span class="r-out co"><span class="r-pr">#></span> 303: 93.8115 -6.0942 -0.1646 2.1762 -0.9850 3.8602 4.1004 0.4227 0.2922 0.1795 5.3976 1.7020</span> -<span class="r-out co"><span class="r-pr">#></span> 304: 93.8106 -6.0979 -0.1645 2.1765 -0.9850 3.8898 4.1217 0.4222 0.2926 0.1798 5.3975 1.7024</span> -<span class="r-out co"><span class="r-pr">#></span> 305: 93.8091 -6.1009 -0.1644 2.1767 -0.9851 3.9165 4.1374 0.4218 0.2931 0.1801 5.3989 1.7024</span> -<span class="r-out co"><span class="r-pr">#></span> 306: 93.8090 -6.1043 -0.1644 2.1770 -0.9850 3.9485 4.1617 0.4214 0.2936 0.1803 5.3998 1.7021</span> -<span class="r-out co"><span class="r-pr">#></span> 307: 93.8082 -6.1063 -0.1644 2.1772 -0.9850 3.9730 4.1797 0.4210 0.2940 0.1803 5.3998 1.7017</span> -<span class="r-out co"><span class="r-pr">#></span> 308: 93.8093 -6.1090 -0.1644 2.1775 -0.9850 3.9874 4.2026 0.4205 0.2945 0.1804 5.3996 1.7006</span> -<span class="r-out co"><span class="r-pr">#></span> 309: 93.8092 -6.1122 -0.1643 2.1777 -0.9849 3.9948 4.2297 0.4201 0.2948 0.1804 5.4001 1.6998</span> -<span class="r-out co"><span class="r-pr">#></span> 310: 93.8080 -6.1142 -0.1642 2.1780 -0.9850 3.9976 4.2436 0.4197 0.2951 0.1803 5.4016 1.6989</span> -<span class="r-out co"><span class="r-pr">#></span> 311: 93.8094 -6.1164 -0.1641 2.1784 -0.9851 4.0015 4.2552 0.4194 0.2952 0.1803 5.4033 1.6978</span> -<span class="r-out co"><span class="r-pr">#></span> 312: 93.8107 -6.1184 -0.1640 2.1788 -0.9851 4.0006 4.2628 0.4190 0.2954 0.1802 5.4042 1.6972</span> -<span class="r-out co"><span class="r-pr">#></span> 313: 93.8118 -6.1190 -0.1640 2.1789 -0.9851 3.9991 4.2638 0.4186 0.2955 0.1802 5.4053 1.6967</span> -<span class="r-out co"><span class="r-pr">#></span> 314: 93.8139 -6.1188 -0.1639 2.1791 -0.9851 4.0019 4.2619 0.4183 0.2956 0.1802 5.4049 1.6966</span> -<span class="r-out co"><span class="r-pr">#></span> 315: 93.8152 -6.1173 -0.1639 2.1792 -0.9851 4.0111 4.2553 0.4179 0.2957 0.1802 5.4052 1.6966</span> -<span class="r-out co"><span class="r-pr">#></span> 316: 93.8178 -6.1158 -0.1639 2.1792 -0.9851 4.0073 4.2498 0.4175 0.2957 0.1802 5.4050 1.6966</span> -<span class="r-out co"><span class="r-pr">#></span> 317: 93.8205 -6.1155 -0.1639 2.1792 -0.9851 3.9999 4.2491 0.4172 0.2957 0.1802 5.4048 1.6963</span> -<span class="r-out co"><span class="r-pr">#></span> 318: 93.8216 -6.1145 -0.1639 2.1792 -0.9850 3.9961 4.2438 0.4168 0.2957 0.1802 5.4031 1.6961</span> -<span class="r-out co"><span class="r-pr">#></span> 319: 93.8241 -6.1143 -0.1639 2.1792 -0.9849 4.0009 4.2412 0.4164 0.2958 0.1801 5.4004 1.6956</span> -<span class="r-out co"><span class="r-pr">#></span> 320: 93.8257 -6.1142 -0.1639 2.1792 -0.9849 4.0018 4.2380 0.4160 0.2958 0.1801 5.3986 1.6952</span> -<span class="r-out co"><span class="r-pr">#></span> 321: 93.8280 -6.1134 -0.1639 2.1792 -0.9849 4.0055 4.2339 0.4156 0.2959 0.1802 5.3966 1.6950</span> -<span class="r-out co"><span class="r-pr">#></span> 322: 93.8299 -6.1122 -0.1639 2.1793 -0.9848 4.0075 4.2274 0.4152 0.2959 0.1802 5.3969 1.6948</span> -<span class="r-out co"><span class="r-pr">#></span> 323: 93.8318 -6.1123 -0.1639 2.1794 -0.9848 4.0087 4.2257 0.4149 0.2960 0.1802 5.3980 1.6941</span> -<span class="r-out co"><span class="r-pr">#></span> 324: 93.8352 -6.1098 -0.1639 2.1795 -0.9848 4.0123 4.2136 0.4145 0.2960 0.1802 5.3988 1.6936</span> -<span class="r-out co"><span class="r-pr">#></span> 325: 93.8374 -6.1072 -0.1638 2.1796 -0.9848 4.0230 4.2005 0.4142 0.2961 0.1802 5.3991 1.6933</span> -<span class="r-out co"><span class="r-pr">#></span> 326: 93.8410 -6.1050 -0.1637 2.1796 -0.9849 4.0327 4.1891 0.4139 0.2963 0.1802 5.4004 1.6927</span> -<span class="r-out co"><span class="r-pr">#></span> 327: 93.8457 -6.1023 -0.1637 2.1796 -0.9849 4.0327 4.1767 0.4135 0.2964 0.1802 5.4013 1.6922</span> -<span class="r-out co"><span class="r-pr">#></span> 328: 93.8493 -6.1017 -0.1637 2.1797 -0.9850 4.0440 4.1730 0.4131 0.2964 0.1802 5.4019 1.6915</span> -<span class="r-out co"><span class="r-pr">#></span> 329: 93.8515 -6.1001 -0.1637 2.1799 -0.9851 4.0556 4.1648 0.4128 0.2963 0.1803 5.4017 1.6912</span> -<span class="r-out co"><span class="r-pr">#></span> 330: 93.8541 -6.1001 -0.1636 2.1800 -0.9852 4.0606 4.1631 0.4124 0.2962 0.1804 5.4025 1.6912</span> -<span class="r-out co"><span class="r-pr">#></span> 331: 93.8539 -6.0994 -0.1635 2.1801 -0.9854 4.0654 4.1584 0.4120 0.2961 0.1805 5.4025 1.6907</span> -<span class="r-out co"><span class="r-pr">#></span> 332: 93.8536 -6.0999 -0.1634 2.1803 -0.9854 4.0696 4.1601 0.4116 0.2960 0.1808 5.4027 1.6904</span> -<span class="r-out co"><span class="r-pr">#></span> 333: 93.8531 -6.1002 -0.1633 2.1806 -0.9853 4.0682 4.1646 0.4112 0.2960 0.1810 5.4038 1.6893</span> -<span class="r-out co"><span class="r-pr">#></span> 334: 93.8543 -6.1005 -0.1632 2.1809 -0.9852 4.0771 4.1690 0.4108 0.2960 0.1812 5.4040 1.6883</span> -<span class="r-out co"><span class="r-pr">#></span> 335: 93.8552 -6.1010 -0.1631 2.1813 -0.9851 4.0888 4.1775 0.4104 0.2960 0.1813 5.4044 1.6878</span> -<span class="r-out co"><span class="r-pr">#></span> 336: 93.8555 -6.1016 -0.1630 2.1817 -0.9850 4.0969 4.1858 0.4099 0.2961 0.1814 5.4046 1.6873</span> -<span class="r-out co"><span class="r-pr">#></span> 337: 93.8553 -6.1025 -0.1628 2.1820 -0.9849 4.1152 4.1921 0.4094 0.2962 0.1815 5.4070 1.6863</span> -<span class="r-out co"><span class="r-pr">#></span> 338: 93.8553 -6.1018 -0.1626 2.1824 -0.9848 4.1314 4.1904 0.4090 0.2963 0.1816 5.4080 1.6852</span> -<span class="r-out co"><span class="r-pr">#></span> 339: 93.8567 -6.1004 -0.1625 2.1828 -0.9847 4.1449 4.1855 0.4087 0.2964 0.1817 5.4087 1.6841</span> -<span class="r-out co"><span class="r-pr">#></span> 340: 93.8582 -6.0987 -0.1623 2.1832 -0.9846 4.1603 4.1799 0.4083 0.2965 0.1819 5.4086 1.6832</span> -<span class="r-out co"><span class="r-pr">#></span> 341: 93.8589 -6.0962 -0.1620 2.1836 -0.9844 4.1692 4.1694 0.4079 0.2965 0.1820 5.4102 1.6828</span> -<span class="r-out co"><span class="r-pr">#></span> 342: 93.8583 -6.0932 -0.1618 2.1841 -0.9844 4.1729 4.1563 0.4075 0.2966 0.1821 5.4117 1.6821</span> -<span class="r-out co"><span class="r-pr">#></span> 343: 93.8590 -6.0906 -0.1615 2.1845 -0.9844 4.1840 4.1447 0.4071 0.2966 0.1822 5.4125 1.6819</span> -<span class="r-out co"><span class="r-pr">#></span> 344: 93.8582 -6.0890 -0.1613 2.1851 -0.9845 4.1860 4.1347 0.4068 0.2968 0.1826 5.4135 1.6814</span> -<span class="r-out co"><span class="r-pr">#></span> 345: 93.8576 -6.0876 -0.1610 2.1857 -0.9846 4.1889 4.1252 0.4064 0.2969 0.1829 5.4143 1.6810</span> -<span class="r-out co"><span class="r-pr">#></span> 346: 93.8549 -6.0853 -0.1608 2.1862 -0.9845 4.1925 4.1121 0.4061 0.2969 0.1832 5.4157 1.6803</span> -<span class="r-out co"><span class="r-pr">#></span> 347: 93.8540 -6.0829 -0.1605 2.1867 -0.9845 4.2031 4.0990 0.4058 0.2970 0.1834 5.4158 1.6803</span> -<span class="r-out co"><span class="r-pr">#></span> 348: 93.8516 -6.0814 -0.1602 2.1873 -0.9845 4.2169 4.0885 0.4055 0.2971 0.1836 5.4174 1.6801</span> -<span class="r-out co"><span class="r-pr">#></span> 349: 93.8505 -6.0797 -0.1600 2.1879 -0.9845 4.2253 4.0779 0.4052 0.2971 0.1837 5.4190 1.6799</span> -<span class="r-out co"><span class="r-pr">#></span> 350: 93.8512 -6.0773 -0.1597 2.1885 -0.9845 4.2268 4.0657 0.4049 0.2972 0.1839 5.4209 1.6797</span> -<span class="r-out co"><span class="r-pr">#></span> 351: 93.8507 -6.0754 -0.1595 2.1890 -0.9845 4.2245 4.0559 0.4046 0.2972 0.1840 5.4230 1.6794</span> -<span class="r-out co"><span class="r-pr">#></span> 352: 93.8490 -6.0736 -0.1592 2.1896 -0.9845 4.2296 4.0474 0.4044 0.2973 0.1841 5.4252 1.6790</span> -<span class="r-out co"><span class="r-pr">#></span> 353: 93.8460 -6.0718 -0.1589 2.1901 -0.9845 4.2356 4.0374 0.4042 0.2973 0.1843 5.4272 1.6790</span> -<span class="r-out co"><span class="r-pr">#></span> 354: 93.8437 -6.0695 -0.1586 2.1906 -0.9845 4.2408 4.0255 0.4041 0.2973 0.1844 5.4303 1.6787</span> -<span class="r-out co"><span class="r-pr">#></span> 355: 93.8420 -6.0679 -0.1584 2.1912 -0.9844 4.2428 4.0166 0.4040 0.2973 0.1845 5.4342 1.6785</span> -<span class="r-out co"><span class="r-pr">#></span> 356: 93.8413 -6.0666 -0.1581 2.1916 -0.9843 4.2418 4.0072 0.4040 0.2973 0.1845 5.4348 1.6792</span> -<span class="r-out co"><span class="r-pr">#></span> 357: 93.8406 -6.0650 -0.1578 2.1921 -0.9844 4.2531 3.9973 0.4040 0.2973 0.1846 5.4350 1.6798</span> -<span class="r-out co"><span class="r-pr">#></span> 358: 93.8404 -6.0639 -0.1575 2.1926 -0.9844 4.2596 3.9901 0.4040 0.2973 0.1846 5.4357 1.6805</span> -<span class="r-out co"><span class="r-pr">#></span> 359: 93.8373 -6.0630 -0.1572 2.1931 -0.9845 4.2724 3.9820 0.4039 0.2973 0.1848 5.4368 1.6816</span> -<span class="r-out co"><span class="r-pr">#></span> 360: 93.8347 -6.0622 -0.1569 2.1936 -0.9845 4.2788 3.9747 0.4039 0.2973 0.1849 5.4377 1.6824</span> -<span class="r-out co"><span class="r-pr">#></span> 361: 93.8327 -6.0626 -0.1566 2.1942 -0.9846 4.2919 3.9749 0.4038 0.2973 0.1850 5.4382 1.6831</span> -<span class="r-out co"><span class="r-pr">#></span> 362: 93.8326 -6.0629 -0.1562 2.1947 -0.9846 4.2989 3.9737 0.4038 0.2973 0.1850 5.4408 1.6838</span> -<span class="r-out co"><span class="r-pr">#></span> 363: 93.8316 -6.0629 -0.1559 2.1953 -0.9846 4.3007 3.9725 0.4037 0.2972 0.1850 5.4420 1.6842</span> -<span class="r-out co"><span class="r-pr">#></span> 364: 93.8317 -6.0629 -0.1556 2.1957 -0.9846 4.2910 3.9739 0.4038 0.2971 0.1850 5.4430 1.6840</span> -<span class="r-out co"><span class="r-pr">#></span> 365: 93.8317 -6.0629 -0.1553 2.1962 -0.9846 4.2878 3.9759 0.4040 0.2967 0.1849 5.4441 1.6839</span> -<span class="r-out co"><span class="r-pr">#></span> 366: 93.8319 -6.0633 -0.1549 2.1966 -0.9845 4.2870 3.9823 0.4042 0.2963 0.1849 5.4461 1.6839</span> -<span class="r-out co"><span class="r-pr">#></span> 367: 93.8320 -6.0636 -0.1546 2.1971 -0.9845 4.2828 3.9850 0.4042 0.2959 0.1849 5.4479 1.6843</span> -<span class="r-out co"><span class="r-pr">#></span> 368: 93.8312 -6.0635 -0.1544 2.1975 -0.9844 4.2781 3.9859 0.4043 0.2955 0.1849 5.4475 1.6841</span> -<span class="r-out co"><span class="r-pr">#></span> 369: 93.8301 -6.0640 -0.1541 2.1979 -0.9844 4.2760 3.9891 0.4043 0.2953 0.1850 5.4472 1.6835</span> -<span class="r-out co"><span class="r-pr">#></span> 370: 93.8306 -6.0651 -0.1539 2.1983 -0.9844 4.2690 3.9967 0.4042 0.2950 0.1850 5.4484 1.6829</span> -<span class="r-out co"><span class="r-pr">#></span> 371: 93.8312 -6.0669 -0.1536 2.1988 -0.9845 4.2613 4.0111 0.4042 0.2947 0.1851 5.4494 1.6822</span> -<span class="r-out co"><span class="r-pr">#></span> 372: 93.8312 -6.0681 -0.1533 2.1992 -0.9845 4.2585 4.0252 0.4042 0.2945 0.1852 5.4513 1.6817</span> -<span class="r-out co"><span class="r-pr">#></span> 373: 93.8307 -6.0681 -0.1531 2.1996 -0.9846 4.2605 4.0284 0.4042 0.2943 0.1853 5.4523 1.6815</span> -<span class="r-out co"><span class="r-pr">#></span> 374: 93.8305 -6.0678 -0.1529 2.1999 -0.9846 4.2676 4.0279 0.4040 0.2942 0.1853 5.4533 1.6816</span> -<span class="r-out co"><span class="r-pr">#></span> 375: 93.8313 -6.0673 -0.1528 2.2002 -0.9846 4.2708 4.0232 0.4038 0.2940 0.1854 5.4543 1.6813</span> -<span class="r-out co"><span class="r-pr">#></span> 376: 93.8310 -6.0672 -0.1527 2.2004 -0.9846 4.2775 4.0214 0.4037 0.2938 0.1855 5.4538 1.6809</span> -<span class="r-out co"><span class="r-pr">#></span> 377: 93.8298 -6.0666 -0.1526 2.2007 -0.9846 4.2787 4.0166 0.4035 0.2937 0.1856 5.4532 1.6806</span> -<span class="r-out co"><span class="r-pr">#></span> 378: 93.8276 -6.0664 -0.1525 2.2009 -0.9846 4.2781 4.0135 0.4033 0.2935 0.1857 5.4538 1.6801</span> -<span class="r-out co"><span class="r-pr">#></span> 379: 93.8262 -6.0671 -0.1524 2.2012 -0.9846 4.2800 4.0157 0.4031 0.2932 0.1857 5.4530 1.6803</span> -<span class="r-out co"><span class="r-pr">#></span> 380: 93.8243 -6.0675 -0.1523 2.2015 -0.9846 4.2735 4.0168 0.4029 0.2929 0.1857 5.4523 1.6803</span> -<span class="r-out co"><span class="r-pr">#></span> 381: 93.8233 -6.0677 -0.1522 2.2017 -0.9845 4.2670 4.0189 0.4027 0.2926 0.1858 5.4517 1.6798</span> -<span class="r-out co"><span class="r-pr">#></span> 382: 93.8229 -6.0674 -0.1521 2.2019 -0.9845 4.2655 4.0211 0.4025 0.2924 0.1858 5.4510 1.6794</span> -<span class="r-out co"><span class="r-pr">#></span> 383: 93.8196 -6.0681 -0.1521 2.2021 -0.9843 4.2696 4.0291 0.4023 0.2922 0.1859 5.4504 1.6788</span> -<span class="r-out co"><span class="r-pr">#></span> 384: 93.8174 -6.0688 -0.1520 2.2023 -0.9842 4.2851 4.0333 0.4021 0.2919 0.1860 5.4500 1.6783</span> -<span class="r-out co"><span class="r-pr">#></span> 385: 93.8156 -6.0682 -0.1518 2.2028 -0.9840 4.3056 4.0305 0.4019 0.2920 0.1862 5.4503 1.6774</span> -<span class="r-out co"><span class="r-pr">#></span> 386: 93.8145 -6.0684 -0.1516 2.2032 -0.9838 4.3195 4.0302 0.4016 0.2920 0.1863 5.4499 1.6765</span> -<span class="r-out co"><span class="r-pr">#></span> 387: 93.8121 -6.0679 -0.1514 2.2036 -0.9837 4.3290 4.0272 0.4014 0.2920 0.1864 5.4501 1.6756</span> -<span class="r-out co"><span class="r-pr">#></span> 388: 93.8105 -6.0676 -0.1513 2.2040 -0.9835 4.3393 4.0267 0.4011 0.2920 0.1865 5.4509 1.6751</span> -<span class="r-out co"><span class="r-pr">#></span> 389: 93.8089 -6.0664 -0.1510 2.2045 -0.9833 4.3458 4.0224 0.4009 0.2920 0.1865 5.4512 1.6746</span> -<span class="r-out co"><span class="r-pr">#></span> 390: 93.8080 -6.0658 -0.1508 2.2049 -0.9832 4.3422 4.0199 0.4007 0.2920 0.1866 5.4514 1.6744</span> -<span class="r-out co"><span class="r-pr">#></span> 391: 93.8077 -6.0669 -0.1507 2.2053 -0.9831 4.3500 4.0277 0.4007 0.2920 0.1867 5.4511 1.6740</span> -<span class="r-out co"><span class="r-pr">#></span> 392: 93.8069 -6.0676 -0.1505 2.2056 -0.9831 4.3525 4.0326 0.4006 0.2920 0.1868 5.4500 1.6733</span> -<span class="r-out co"><span class="r-pr">#></span> 393: 93.8072 -6.0678 -0.1504 2.2059 -0.9830 4.3562 4.0344 0.4005 0.2920 0.1868 5.4491 1.6725</span> -<span class="r-out co"><span class="r-pr">#></span> 394: 93.8083 -6.0684 -0.1503 2.2061 -0.9829 4.3577 4.0386 0.4004 0.2920 0.1869 5.4493 1.6716</span> -<span class="r-out co"><span class="r-pr">#></span> 395: 93.8086 -6.0685 -0.1501 2.2064 -0.9828 4.3574 4.0394 0.4003 0.2920 0.1869 5.4493 1.6709</span> -<span class="r-out co"><span class="r-pr">#></span> 396: 93.8078 -6.0677 -0.1500 2.2067 -0.9827 4.3591 4.0355 0.4002 0.2921 0.1870 5.4493 1.6707</span> -<span class="r-out co"><span class="r-pr">#></span> 397: 93.8064 -6.0668 -0.1499 2.2071 -0.9825 4.3621 4.0317 0.4000 0.2922 0.1871 5.4495 1.6704</span> -<span class="r-out co"><span class="r-pr">#></span> 398: 93.8058 -6.0661 -0.1499 2.2073 -0.9823 4.3701 4.0285 0.3999 0.2923 0.1872 5.4491 1.6699</span> -<span class="r-out co"><span class="r-pr">#></span> 399: 93.8057 -6.0651 -0.1498 2.2075 -0.9822 4.3803 4.0243 0.3997 0.2924 0.1872 5.4485 1.6699</span> -<span class="r-out co"><span class="r-pr">#></span> 400: 93.8057 -6.0647 -0.1498 2.2076 -0.9820 4.3854 4.0225 0.3996 0.2924 0.1872 5.4488 1.6699</span> -<span class="r-out co"><span class="r-pr">#></span> 401: 93.8059 -6.0635 -0.1498 2.2078 -0.9819 4.3939 4.0178 0.3995 0.2925 0.1873 5.4491 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 402: 93.8063 -6.0621 -0.1498 2.2079 -0.9818 4.4033 4.0120 0.3993 0.2926 0.1875 5.4492 1.6704</span> -<span class="r-out co"><span class="r-pr">#></span> 403: 93.8055 -6.0609 -0.1498 2.2080 -0.9816 4.4098 4.0069 0.3992 0.2926 0.1876 5.4494 1.6703</span> -<span class="r-out co"><span class="r-pr">#></span> 404: 93.8040 -6.0608 -0.1499 2.2081 -0.9815 4.4153 4.0050 0.3991 0.2927 0.1877 5.4494 1.6701</span> -<span class="r-out co"><span class="r-pr">#></span> 405: 93.8030 -6.0604 -0.1499 2.2082 -0.9814 4.4181 4.0047 0.3990 0.2928 0.1879 5.4491 1.6700</span> -<span class="r-out co"><span class="r-pr">#></span> 406: 93.8002 -6.0597 -0.1499 2.2083 -0.9812 4.4257 4.0025 0.3989 0.2928 0.1880 5.4498 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 407: 93.7969 -6.0593 -0.1500 2.2085 -0.9810 4.4343 3.9994 0.3988 0.2928 0.1881 5.4514 1.6703</span> -<span class="r-out co"><span class="r-pr">#></span> 408: 93.7947 -6.0582 -0.1499 2.2087 -0.9809 4.4509 3.9936 0.3987 0.2927 0.1882 5.4526 1.6704</span> -<span class="r-out co"><span class="r-pr">#></span> 409: 93.7929 -6.0579 -0.1499 2.2088 -0.9807 4.4584 3.9918 0.3987 0.2926 0.1882 5.4537 1.6707</span> -<span class="r-out co"><span class="r-pr">#></span> 410: 93.7896 -6.0593 -0.1499 2.2089 -0.9807 4.4664 4.0002 0.3987 0.2925 0.1883 5.4560 1.6705</span> -<span class="r-out co"><span class="r-pr">#></span> 411: 93.7875 -6.0601 -0.1499 2.2090 -0.9807 4.4626 4.0057 0.3987 0.2924 0.1883 5.4567 1.6705</span> -<span class="r-out co"><span class="r-pr">#></span> 412: 93.7862 -6.0602 -0.1499 2.2091 -0.9808 4.4574 4.0095 0.3986 0.2923 0.1884 5.4565 1.6706</span> -<span class="r-out co"><span class="r-pr">#></span> 413: 93.7858 -6.0606 -0.1498 2.2092 -0.9808 4.4527 4.0146 0.3986 0.2922 0.1885 5.4561 1.6708</span> -<span class="r-out co"><span class="r-pr">#></span> 414: 93.7859 -6.0615 -0.1498 2.2093 -0.9808 4.4451 4.0211 0.3987 0.2921 0.1885 5.4574 1.6708</span> -<span class="r-out co"><span class="r-pr">#></span> 415: 93.7864 -6.0629 -0.1498 2.2092 -0.9808 4.4443 4.0298 0.3986 0.2921 0.1885 5.4576 1.6707</span> -<span class="r-out co"><span class="r-pr">#></span> 416: 93.7851 -6.0639 -0.1498 2.2092 -0.9808 4.4462 4.0362 0.3985 0.2920 0.1884 5.4575 1.6706</span> -<span class="r-out co"><span class="r-pr">#></span> 417: 93.7820 -6.0644 -0.1499 2.2092 -0.9808 4.4425 4.0387 0.3985 0.2920 0.1884 5.4577 1.6703</span> -<span class="r-out co"><span class="r-pr">#></span> 418: 93.7801 -6.0652 -0.1499 2.2093 -0.9808 4.4365 4.0420 0.3985 0.2920 0.1883 5.4589 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 419: 93.7799 -6.0648 -0.1499 2.2094 -0.9807 4.4303 4.0418 0.3984 0.2921 0.1883 5.4596 1.6703</span> -<span class="r-out co"><span class="r-pr">#></span> 420: 93.7797 -6.0641 -0.1498 2.2095 -0.9807 4.4216 4.0383 0.3983 0.2921 0.1884 5.4607 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 421: 93.7803 -6.0641 -0.1498 2.2096 -0.9808 4.4120 4.0396 0.3983 0.2922 0.1885 5.4621 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 422: 93.7806 -6.0638 -0.1498 2.2097 -0.9809 4.4017 4.0373 0.3981 0.2923 0.1885 5.4635 1.6702</span> -<span class="r-out co"><span class="r-pr">#></span> 423: 93.7800 -6.0636 -0.1498 2.2098 -0.9810 4.3948 4.0339 0.3981 0.2923 0.1885 5.4640 1.6701</span> -<span class="r-out co"><span class="r-pr">#></span> 424: 93.7789 -6.0638 -0.1498 2.2099 -0.9810 4.3884 4.0336 0.3980 0.2924 0.1885 5.4651 1.6700</span> -<span class="r-out co"><span class="r-pr">#></span> 425: 93.7774 -6.0628 -0.1498 2.2101 -0.9810 4.3814 4.0271 0.3978 0.2925 0.1884 5.4666 1.6699</span> -<span class="r-out co"><span class="r-pr">#></span> 426: 93.7755 -6.0619 -0.1498 2.2102 -0.9811 4.3841 4.0221 0.3977 0.2925 0.1884 5.4693 1.6697</span> -<span class="r-out co"><span class="r-pr">#></span> 427: 93.7753 -6.0612 -0.1498 2.2103 -0.9810 4.3785 4.0167 0.3975 0.2926 0.1883 5.4712 1.6696</span> -<span class="r-out co"><span class="r-pr">#></span> 428: 93.7741 -6.0613 -0.1498 2.2104 -0.9810 4.3767 4.0161 0.3973 0.2926 0.1882 5.4729 1.6696</span> -<span class="r-out co"><span class="r-pr">#></span> 429: 93.7717 -6.0613 -0.1498 2.2105 -0.9810 4.3744 4.0158 0.3971 0.2926 0.1880 5.4743 1.6694</span> -<span class="r-out co"><span class="r-pr">#></span> 430: 93.7690 -6.0619 -0.1498 2.2106 -0.9809 4.3744 4.0189 0.3969 0.2926 0.1879 5.4753 1.6692</span> -<span class="r-out co"><span class="r-pr">#></span> 431: 93.7668 -6.0615 -0.1498 2.2107 -0.9809 4.3709 4.0174 0.3967 0.2925 0.1878 5.4762 1.6691</span> -<span class="r-out co"><span class="r-pr">#></span> 432: 93.7656 -6.0619 -0.1498 2.2108 -0.9809 4.3710 4.0173 0.3966 0.2926 0.1878 5.4770 1.6688</span> -<span class="r-out co"><span class="r-pr">#></span> 433: 93.7632 -6.0625 -0.1498 2.2108 -0.9809 4.3689 4.0204 0.3964 0.2926 0.1877 5.4774 1.6687</span> -<span class="r-out co"><span class="r-pr">#></span> 434: 93.7624 -6.0621 -0.1498 2.2109 -0.9808 4.3687 4.0178 0.3962 0.2926 0.1876 5.4774 1.6683</span> -<span class="r-out co"><span class="r-pr">#></span> 435: 93.7608 -6.0622 -0.1497 2.2111 -0.9808 4.3714 4.0182 0.3961 0.2927 0.1875 5.4777 1.6679</span> -<span class="r-out co"><span class="r-pr">#></span> 436: 93.7586 -6.0622 -0.1498 2.2112 -0.9808 4.3695 4.0178 0.3959 0.2928 0.1874 5.4784 1.6679</span> -<span class="r-out co"><span class="r-pr">#></span> 437: 93.7558 -6.0622 -0.1498 2.2114 -0.9809 4.3658 4.0167 0.3957 0.2928 0.1873 5.4795 1.6678</span> -<span class="r-out co"><span class="r-pr">#></span> 438: 93.7519 -6.0627 -0.1499 2.2115 -0.9808 4.3601 4.0183 0.3955 0.2928 0.1872 5.4807 1.6674</span> -<span class="r-out co"><span class="r-pr">#></span> 439: 93.7478 -6.0618 -0.1499 2.2115 -0.9807 4.3538 4.0133 0.3952 0.2928 0.1871 5.4814 1.6672</span> -<span class="r-out co"><span class="r-pr">#></span> 440: 93.7449 -6.0612 -0.1499 2.2117 -0.9805 4.3504 4.0103 0.3951 0.2928 0.1870 5.4820 1.6669</span> -<span class="r-out co"><span class="r-pr">#></span> 441: 93.7433 -6.0608 -0.1499 2.2117 -0.9805 4.3438 4.0077 0.3949 0.2928 0.1869 5.4818 1.6666</span> -<span class="r-out co"><span class="r-pr">#></span> 442: 93.7417 -6.0604 -0.1500 2.2118 -0.9805 4.3354 4.0058 0.3947 0.2927 0.1868 5.4824 1.6666</span> -<span class="r-out co"><span class="r-pr">#></span> 443: 93.7407 -6.0604 -0.1500 2.2119 -0.9805 4.3281 4.0046 0.3946 0.2927 0.1867 5.4832 1.6667</span> -<span class="r-out co"><span class="r-pr">#></span> 444: 93.7397 -6.0608 -0.1500 2.2118 -0.9805 4.3180 4.0069 0.3944 0.2928 0.1866 5.4857 1.6664</span> -<span class="r-out co"><span class="r-pr">#></span> 445: 93.7387 -6.0613 -0.1501 2.2118 -0.9805 4.3092 4.0085 0.3942 0.2929 0.1866 5.4866 1.6663</span> -<span class="r-out co"><span class="r-pr">#></span> 446: 93.7376 -6.0612 -0.1502 2.2117 -0.9805 4.3022 4.0075 0.3939 0.2930 0.1865 5.4866 1.6660</span> -<span class="r-out co"><span class="r-pr">#></span> 447: 93.7375 -6.0613 -0.1503 2.2116 -0.9806 4.2981 4.0076 0.3937 0.2931 0.1865 5.4863 1.6658</span> -<span class="r-out co"><span class="r-pr">#></span> 448: 93.7388 -6.0617 -0.1504 2.2115 -0.9806 4.2970 4.0087 0.3935 0.2932 0.1864 5.4870 1.6658</span> -<span class="r-out co"><span class="r-pr">#></span> 449: 93.7400 -6.0617 -0.1504 2.2115 -0.9807 4.2904 4.0069 0.3933 0.2933 0.1864 5.4880 1.6655</span> -<span class="r-out co"><span class="r-pr">#></span> 450: 93.7414 -6.0623 -0.1505 2.2113 -0.9808 4.2829 4.0095 0.3930 0.2935 0.1863 5.4880 1.6653</span> -<span class="r-out co"><span class="r-pr">#></span> 451: 93.7426 -6.0634 -0.1506 2.2112 -0.9808 4.2797 4.0146 0.3928 0.2936 0.1863 5.4877 1.6655</span> -<span class="r-out co"><span class="r-pr">#></span> 452: 93.7447 -6.0642 -0.1507 2.2110 -0.9809 4.2770 4.0171 0.3926 0.2938 0.1862 5.4876 1.6657</span> -<span class="r-out co"><span class="r-pr">#></span> 453: 93.7465 -6.0644 -0.1508 2.2108 -0.9810 4.2698 4.0184 0.3924 0.2940 0.1862 5.4877 1.6652</span> -<span class="r-out co"><span class="r-pr">#></span> 454: 93.7478 -6.0645 -0.1509 2.2106 -0.9810 4.2657 4.0182 0.3922 0.2941 0.1861 5.4874 1.6648</span> -<span class="r-out co"><span class="r-pr">#></span> 455: 93.7486 -6.0650 -0.1511 2.2104 -0.9811 4.2656 4.0203 0.3921 0.2943 0.1861 5.4871 1.6644</span> -<span class="r-out co"><span class="r-pr">#></span> 456: 93.7485 -6.0659 -0.1512 2.2102 -0.9812 4.2646 4.0240 0.3920 0.2945 0.1860 5.4869 1.6641</span> -<span class="r-out co"><span class="r-pr">#></span> 457: 93.7487 -6.0668 -0.1514 2.2099 -0.9813 4.2613 4.0277 0.3919 0.2946 0.1860 5.4866 1.6640</span> -<span class="r-out co"><span class="r-pr">#></span> 458: 93.7484 -6.0667 -0.1515 2.2097 -0.9812 4.2586 4.0263 0.3918 0.2947 0.1859 5.4854 1.6639</span> -<span class="r-out co"><span class="r-pr">#></span> 459: 93.7468 -6.0661 -0.1517 2.2095 -0.9812 4.2565 4.0225 0.3917 0.2948 0.1858 5.4853 1.6639</span> -<span class="r-out co"><span class="r-pr">#></span> 460: 93.7458 -6.0652 -0.1518 2.2093 -0.9812 4.2548 4.0171 0.3916 0.2950 0.1858 5.4843 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 461: 93.7435 -6.0645 -0.1519 2.2091 -0.9811 4.2554 4.0121 0.3914 0.2951 0.1858 5.4843 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 462: 93.7421 -6.0637 -0.1521 2.2089 -0.9811 4.2509 4.0079 0.3913 0.2953 0.1857 5.4840 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 463: 93.7406 -6.0630 -0.1522 2.2088 -0.9810 4.2534 4.0036 0.3912 0.2955 0.1857 5.4834 1.6640</span> -<span class="r-out co"><span class="r-pr">#></span> 464: 93.7406 -6.0622 -0.1524 2.2086 -0.9810 4.2548 3.9986 0.3911 0.2956 0.1857 5.4828 1.6639</span> -<span class="r-out co"><span class="r-pr">#></span> 465: 93.7404 -6.0617 -0.1525 2.2084 -0.9810 4.2511 3.9955 0.3910 0.2958 0.1857 5.4828 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 466: 93.7414 -6.0610 -0.1527 2.2080 -0.9809 4.2468 3.9918 0.3910 0.2959 0.1857 5.4812 1.6640</span> -<span class="r-out co"><span class="r-pr">#></span> 467: 93.7419 -6.0606 -0.1529 2.2077 -0.9810 4.2446 3.9885 0.3909 0.2960 0.1858 5.4799 1.6642</span> -<span class="r-out co"><span class="r-pr">#></span> 468: 93.7427 -6.0604 -0.1531 2.2074 -0.9809 4.2473 3.9872 0.3909 0.2961 0.1858 5.4790 1.6643</span> -<span class="r-out co"><span class="r-pr">#></span> 469: 93.7435 -6.0608 -0.1532 2.2073 -0.9810 4.2457 3.9891 0.3907 0.2963 0.1858 5.4789 1.6641</span> -<span class="r-out co"><span class="r-pr">#></span> 470: 93.7442 -6.0611 -0.1533 2.2071 -0.9811 4.2443 3.9895 0.3905 0.2965 0.1858 5.4785 1.6640</span> -<span class="r-out co"><span class="r-pr">#></span> 471: 93.7443 -6.0618 -0.1534 2.2070 -0.9812 4.2415 3.9932 0.3903 0.2967 0.1858 5.4773 1.6639</span> -<span class="r-out co"><span class="r-pr">#></span> 472: 93.7433 -6.0624 -0.1535 2.2069 -0.9812 4.2414 3.9958 0.3901 0.2969 0.1858 5.4765 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 473: 93.7421 -6.0621 -0.1536 2.2067 -0.9811 4.2330 3.9962 0.3899 0.2970 0.1858 5.4762 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 474: 93.7415 -6.0621 -0.1537 2.2066 -0.9812 4.2263 3.9968 0.3897 0.2972 0.1858 5.4755 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 475: 93.7396 -6.0621 -0.1538 2.2066 -0.9812 4.2261 3.9956 0.3895 0.2973 0.1859 5.4751 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 476: 93.7373 -6.0626 -0.1539 2.2065 -0.9811 4.2265 3.9976 0.3893 0.2975 0.1859 5.4743 1.6634</span> -<span class="r-out co"><span class="r-pr">#></span> 477: 93.7357 -6.0623 -0.1540 2.2063 -0.9811 4.2222 3.9953 0.3891 0.2976 0.1859 5.4741 1.6635</span> -<span class="r-out co"><span class="r-pr">#></span> 478: 93.7345 -6.0620 -0.1541 2.2062 -0.9811 4.2165 3.9939 0.3889 0.2978 0.1860 5.4745 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 479: 93.7341 -6.0615 -0.1542 2.2062 -0.9812 4.2122 3.9916 0.3887 0.2979 0.1860 5.4751 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 480: 93.7338 -6.0619 -0.1543 2.2061 -0.9812 4.2084 3.9932 0.3885 0.2980 0.1860 5.4753 1.6635</span> -<span class="r-out co"><span class="r-pr">#></span> 481: 93.7336 -6.0618 -0.1544 2.2060 -0.9812 4.2066 3.9945 0.3883 0.2981 0.1860 5.4748 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 482: 93.7340 -6.0622 -0.1545 2.2058 -0.9812 4.2069 3.9969 0.3882 0.2983 0.1860 5.4741 1.6636</span> -<span class="r-out co"><span class="r-pr">#></span> 483: 93.7328 -6.0627 -0.1547 2.2057 -0.9813 4.2062 3.9992 0.3879 0.2985 0.1861 5.4739 1.6636</span> -<span class="r-out co"><span class="r-pr">#></span> 484: 93.7323 -6.0629 -0.1547 2.2056 -0.9813 4.2075 3.9995 0.3877 0.2987 0.1861 5.4730 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 485: 93.7326 -6.0634 -0.1548 2.2055 -0.9814 4.2045 4.0013 0.3875 0.2989 0.1862 5.4727 1.6637</span> -<span class="r-out co"><span class="r-pr">#></span> 486: 93.7320 -6.0632 -0.1549 2.2055 -0.9814 4.2084 3.9989 0.3872 0.2991 0.1863 5.4718 1.6635</span> -<span class="r-out co"><span class="r-pr">#></span> 487: 93.7321 -6.0625 -0.1549 2.2054 -0.9814 4.2105 3.9949 0.3870 0.2993 0.1864 5.4712 1.6634</span> -<span class="r-out co"><span class="r-pr">#></span> 488: 93.7326 -6.0623 -0.1550 2.2054 -0.9814 4.2104 3.9935 0.3868 0.2996 0.1865 5.4721 1.6635</span> -<span class="r-out co"><span class="r-pr">#></span> 489: 93.7342 -6.0615 -0.1551 2.2054 -0.9815 4.2103 3.9893 0.3866 0.2998 0.1866 5.4725 1.6635</span> -<span class="r-out co"><span class="r-pr">#></span> 490: 93.7360 -6.0610 -0.1551 2.2053 -0.9815 4.2116 3.9857 0.3864 0.3001 0.1867 5.4730 1.6636</span> -<span class="r-out co"><span class="r-pr">#></span> 491: 93.7374 -6.0601 -0.1551 2.2052 -0.9815 4.2128 3.9804 0.3862 0.3003 0.1868 5.4722 1.6638</span> -<span class="r-out co"><span class="r-pr">#></span> 492: 93.7386 -6.0597 -0.1552 2.2050 -0.9816 4.2171 3.9774 0.3861 0.3006 0.1869 5.4714 1.6642</span> -<span class="r-out co"><span class="r-pr">#></span> 493: 93.7399 -6.0597 -0.1553 2.2049 -0.9816 4.2262 3.9766 0.3859 0.3008 0.1869 5.4712 1.6643</span> -<span class="r-out co"><span class="r-pr">#></span> 494: 93.7404 -6.0596 -0.1553 2.2047 -0.9816 4.2347 3.9746 0.3857 0.3011 0.1870 5.4711 1.6646</span> -<span class="r-out co"><span class="r-pr">#></span> 495: 93.7406 -6.0590 -0.1554 2.2046 -0.9817 4.2395 3.9711 0.3855 0.3014 0.1871 5.4705 1.6650</span> -<span class="r-out co"><span class="r-pr">#></span> 496: 93.7416 -6.0582 -0.1554 2.2045 -0.9817 4.2456 3.9660 0.3853 0.3017 0.1871 5.4707 1.6656</span> -<span class="r-out co"><span class="r-pr">#></span> 497: 93.7433 -6.0575 -0.1555 2.2044 -0.9818 4.2511 3.9631 0.3851 0.3020 0.1871 5.4714 1.6658</span> -<span class="r-out co"><span class="r-pr">#></span> 498: 93.7444 -6.0574 -0.1556 2.2042 -0.9817 4.2516 3.9632 0.3848 0.3023 0.1871 5.4721 1.6660</span> -<span class="r-out co"><span class="r-pr">#></span> 499: 93.7457 -6.0576 -0.1557 2.2041 -0.9817 4.2518 3.9660 0.3846 0.3025 0.1871 5.4728 1.6660</span> -<span class="r-out co"><span class="r-pr">#></span> 500: 93.7469 -6.0586 -0.1557 2.2040 -0.9817 4.2481 3.9757 0.3844 0.3028 0.1871 5.4738 1.6661</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta |sigma_parent | sigma_A1 | o1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 468.02617 | 1.000 | -1.000 | -0.9113 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8491 | -0.8511 | -0.8672 | -0.8762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8737 | -0.8674 | -0.8694 | -0.8687 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.02617 | 94.00 | -5.400 | -0.9900 | -0.2000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.000 | 1.200 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.189 | 1.093 | 1.127 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.02617</span> | 94.00 | 0.004517 | 0.2709 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.166 | 2.000 | 1.200 | 0.7536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.189 | 1.093 | 1.127 |</span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 49.30 | 2.016 | -0.2473 | -0.3737 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.227 | -27.89 | -10.29 | 8.753 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.17 | -12.52 | -9.819 | -8.910 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 4021.4865 | 0.2059 | -1.032 | -0.9073 | -0.8894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8293 | -0.4019 | -0.7014 | -1.017 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.054 | -0.6658 | -0.7112 | -0.7251 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 4021.4865 | 19.35 | -5.432 | -0.9861 | -0.1940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.120 | 2.449 | 1.299 | 0.6474 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7182 | 1.429 | 1.266 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 4021.4865</span> | 19.35 | 0.004372 | 0.2717 | 0.8237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.329 | 2.449 | 1.299 | 0.6474 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7182 | 1.429 | 1.266 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 518.20369 | 0.9206 | -1.003 | -0.9109 | -0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.8062 | -0.8506 | -0.8903 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.8473 | -0.8535 | -0.8543 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 518.20369 | 86.53 | -5.403 | -0.9896 | -0.1994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.045 | 1.210 | 0.7430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.213 | 1.111 | 1.143 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 518.20369</span> | 86.53 | 0.004502 | 0.2710 | 0.8192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.182 | 2.045 | 1.210 | 0.7430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.213 | 1.111 | 1.143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 467.99742 | 0.9921 | -1.000 | -0.9112 | -0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.8466 | -0.8655 | -0.8776 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8755 | -0.8654 | -0.8678 | -0.8672 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.99742 | 93.25 | -5.400 | -0.9900 | -0.1999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.004 | 1.201 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8742 | 1.192 | 1.095 | 1.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.99742</span> | 93.25 | 0.004515 | 0.2709 | 0.8188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 2.004 | 1.201 | 0.7526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8742 | 1.192 | 1.095 | 1.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -98.28 | 1.929 | -0.4044 | -0.4503 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.484 | -29.27 | -9.987 | 8.922 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.417 | -11.79 | -9.521 | -8.343 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 467.67344 | 0.9967 | -1.000 | -0.9112 | -0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8488 | -0.8452 | -0.8651 | -0.8780 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8760 | -0.8648 | -0.8673 | -0.8668 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.67344 | 93.69 | -5.400 | -0.9899 | -0.1999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.006 | 1.201 | 0.7523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8738 | 1.192 | 1.095 | 1.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.67344</span> | 93.69 | 0.004515 | 0.2709 | 0.8188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.168 | 2.006 | 1.201 | 0.7523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8738 | 1.192 | 1.095 | 1.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.92 | 1.963 | -0.3242 | -0.4184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.350 | -28.16 | -10.02 | 8.541 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.305 | -11.80 | -9.512 | -8.408 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 467.50396 | 0.9983 | -1.001 | -0.9112 | -0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8487 | -0.8416 | -0.8638 | -0.8791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8771 | -0.8633 | -0.8661 | -0.8658 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.50396 | 93.84 | -5.401 | -0.9899 | -0.1999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.100 | 2.010 | 1.202 | 0.7514 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8729 | 1.194 | 1.097 | 1.130 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.50396</span> | 93.84 | 0.004514 | 0.2709 | 0.8188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.170 | 2.010 | 1.202 | 0.7514 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8729 | 1.194 | 1.097 | 1.130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 467.27231 | 1.003 | -1.001 | -0.9110 | -0.8951 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.8306 | -0.8599 | -0.8825 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8803 | -0.8587 | -0.8624 | -0.8625 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.27231 | 94.27 | -5.401 | -0.9898 | -0.1997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.101 | 2.021 | 1.204 | 0.7489 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8700 | 1.200 | 1.101 | 1.134 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.27231</span> | 94.27 | 0.004510 | 0.2710 | 0.8190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.174 | 2.021 | 1.204 | 0.7489 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8700 | 1.200 | 1.101 | 1.134 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 101.6 | 1.991 | -0.1997 | -0.3688 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.177 | -25.72 | -9.853 | 9.249 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.335 | -11.58 | -9.288 | -8.277 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 466.36087 | 0.9961 | -1.002 | -0.9109 | -0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8474 | -0.8165 | -0.8547 | -0.8873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8853 | -0.8526 | -0.8575 | -0.8582 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.36087 | 93.63 | -5.402 | -0.9896 | -0.1995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.035 | 1.207 | 0.7453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8657 | 1.207 | 1.106 | 1.139 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.36087</span> | 93.63 | 0.004506 | 0.2710 | 0.8191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.180 | 2.035 | 1.207 | 0.7453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8657 | 1.207 | 1.106 | 1.139 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -21.78 | 1.909 | -0.3215 | -0.4291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.401 | -25.38 | -9.315 | 7.655 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 10.17 | -11.26 | -9.035 | -7.894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 465.79764 | 1.000 | -1.004 | -0.9107 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.8024 | -0.8495 | -0.8920 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.8462 | -0.8524 | -0.8537 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 465.79764 | 94.04 | -5.404 | -0.9895 | -0.1993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.102 | 2.049 | 1.211 | 0.7417 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.214 | 1.112 | 1.144 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 465.79764</span> | 94.04 | 0.004501 | 0.2710 | 0.8193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.186 | 2.049 | 1.211 | 0.7417 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8600 | 1.214 | 1.112 | 1.144 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.81 | 1.910 | -0.2489 | -0.4009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.285 | -22.17 | -8.389 | 8.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.340 | -11.02 | -8.786 | -7.720 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 465.18897 | 0.9945 | -1.005 | -0.9105 | -0.8943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8457 | -0.7893 | -0.8445 | -0.8971 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8975 | -0.8390 | -0.8467 | -0.8487 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 465.18897 | 93.48 | -5.405 | -0.9893 | -0.1990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.103 | 2.062 | 1.214 | 0.7379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8549 | 1.223 | 1.118 | 1.149 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 465.18897</span> | 93.48 | 0.004495 | 0.2711 | 0.8196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.194 | 2.062 | 1.214 | 0.7379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8549 | 1.223 | 1.118 | 1.149 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -47.52 | 1.834 | -0.3684 | -0.4503 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.489 | -22.39 | -7.996 | 7.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.249 | -10.90 | -8.741 | -7.575 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 464.56229 | 0.9983 | -1.006 | -0.9102 | -0.8940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8445 | -0.7772 | -0.8401 | -0.9030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9029 | -0.8305 | -0.8400 | -0.8430 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 464.56229 | 93.84 | -5.406 | -0.9890 | -0.1986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.105 | 2.074 | 1.216 | 0.7334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8503 | 1.233 | 1.125 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 464.56229</span> | 93.84 | 0.004488 | 0.2711 | 0.8199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.204 | 2.074 | 1.216 | 0.7334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8503 | 1.233 | 1.125 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 463.71730 | 0.9982 | -1.009 | -0.9098 | -0.8933 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8424 | -0.7583 | -0.8332 | -0.9128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9112 | -0.8167 | -0.8291 | -0.8337 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 463.7173 | 93.83 | -5.409 | -0.9885 | -0.1980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.107 | 2.093 | 1.220 | 0.7260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 1.249 | 1.137 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 463.7173</span> | 93.83 | 0.004478 | 0.2712 | 0.8204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.221 | 2.093 | 1.220 | 0.7260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 1.249 | 1.137 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 461.03699 | 0.9978 | -1.018 | -0.9080 | -0.8909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8343 | -0.6839 | -0.8059 | -0.9516 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9441 | -0.7622 | -0.7862 | -0.7969 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 461.03699 | 93.79 | -5.418 | -0.9868 | -0.1955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.115 | 2.167 | 1.237 | 0.6968 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8141 | 1.314 | 1.184 | 1.208 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 461.03699</span> | 93.79 | 0.004435 | 0.2716 | 0.8224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.288 | 2.167 | 1.237 | 0.6968 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8141 | 1.314 | 1.184 | 1.208 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 458.83693 | 0.9972 | -1.033 | -0.9052 | -0.8871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8218 | -0.5692 | -0.7639 | -1.011 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9948 | -0.6782 | -0.7201 | -0.7403 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.83693 | 93.74 | -5.433 | -0.9840 | -0.1917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.127 | 2.282 | 1.262 | 0.6519 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7697 | 1.414 | 1.256 | 1.272 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.83693</span> | 93.74 | 0.004371 | 0.2721 | 0.8255 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.393 | 2.282 | 1.262 | 0.6519 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7697 | 1.414 | 1.256 | 1.272 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.05416 | 1.397 | -0.2200 | -0.5344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.585 | -3.387 | -1.306 | -0.2250 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.392 | -3.452 | -2.065 | -1.405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 459.30045 | 0.9957 | -1.166 | -0.8845 | -0.8313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6584 | -0.5528 | -0.7505 | -0.8569 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.4560 | -0.6245 | -0.7036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 459.30045 | 93.60 | -5.566 | -0.9635 | -0.1360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | 2.298 | 1.270 | 0.7682 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7505 | 1.678 | 1.361 | 1.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 459.30045</span> | 93.60 | 0.003827 | 0.2762 | 0.8729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.881 | 2.298 | 1.270 | 0.7682 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7505 | 1.678 | 1.361 | 1.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 458.36319 | 0.9960 | -1.071 | -0.8992 | -0.8719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7770 | -0.5045 | -0.7383 | -0.9927 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.5931 | -0.6727 | -0.7107 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.36319 | 93.63 | -5.471 | -0.9780 | -0.1766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.172 | 2.347 | 1.277 | 0.6658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7452 | 1.515 | 1.308 | 1.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.36319</span> | 93.63 | 0.004206 | 0.2733 | 0.8381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.777 | 2.347 | 1.277 | 0.6658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7452 | 1.515 | 1.308 | 1.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.30 | 1.214 | 0.06343 | -0.2616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6069 | 0.08029 | 0.4273 | 0.07297 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3937 | 0.3470 | 0.5201 | 0.09241 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 458.37724 | 0.9977 | -1.183 | -0.9046 | -0.8476 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7196 | -0.4765 | -0.7567 | -1.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9850 | -0.5955 | -0.6985 | -0.7030 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.37724 | 93.79 | -5.583 | -0.9834 | -0.1522 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.229 | 2.375 | 1.266 | 0.6497 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7783 | 1.513 | 1.280 | 1.314 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.37724</span> | 93.79 | 0.003762 | 0.2722 | 0.8588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.295 | 2.375 | 1.266 | 0.6497 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7783 | 1.513 | 1.280 | 1.314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 458.32800 | 0.9976 | -1.124 | -0.9017 | -0.8605 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7499 | -0.4913 | -0.7470 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.5943 | -0.6849 | -0.7071 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.328 | 93.78 | -5.524 | -0.9806 | -0.1651 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.199 | 2.360 | 1.272 | 0.6583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7608 | 1.514 | 1.295 | 1.309 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.328</span> | 93.78 | 0.003990 | 0.2728 | 0.8478 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.017 | 2.360 | 1.272 | 0.6583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7608 | 1.514 | 1.295 | 1.309 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.757 | 1.093 | -0.06310 | 0.02237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09811 | 0.3115 | -0.3381 | -0.2098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8196 | 0.7052 | 0.04425 | 0.2610 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 458.25889 | 0.9968 | -1.183 | -0.9011 | -0.8543 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7363 | -0.4871 | -0.7422 | -1.003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.6115 | -0.6911 | -0.7106 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.25889 | 93.70 | -5.583 | -0.9799 | -0.1589 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.213 | 2.364 | 1.275 | 0.6583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7450 | 1.494 | 1.288 | 1.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.25889</span> | 93.70 | 0.003760 | 0.2729 | 0.8531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.141 | 2.364 | 1.275 | 0.6583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7450 | 1.494 | 1.288 | 1.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.6125 | 0.8824 | -0.01905 | 0.1697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4368 | 0.4743 | 0.05191 | -0.6440 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4868 | -0.9136 | -0.3225 | -0.06220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 458.18570 | 0.9978 | -1.246 | -0.9006 | -0.8585 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7495 | -0.4978 | -0.7385 | -0.9895 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6046 | -0.6874 | -0.7124 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1857 | 93.79 | -5.646 | -0.9794 | -0.1632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.200 | 2.353 | 1.277 | 0.6683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7440 | 1.502 | 1.292 | 1.303 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1857</span> | 93.79 | 0.003532 | 0.2730 | 0.8495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.022 | 2.353 | 1.277 | 0.6683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7440 | 1.502 | 1.292 | 1.303 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 458.13464 | 0.9963 | -1.435 | -0.8992 | -0.8705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7875 | -0.5278 | -0.7264 | -0.9531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6784 | -0.7184 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.13464 | 93.65 | -5.835 | -0.9781 | -0.1751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.323 | 1.284 | 0.6957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7378 | 1.519 | 1.302 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.13464</span> | 93.65 | 0.002922 | 0.2733 | 0.8394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.685 | 2.323 | 1.284 | 0.6957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7378 | 1.519 | 1.302 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.15 | 0.2290 | 0.2476 | -0.1455 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7111 | -1.138 | 0.8895 | 1.880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.837 | 0.2029 | 0.3485 | -0.6531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 458.67841 | 0.9992 | -1.651 | -0.9027 | -0.9245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8733 | -0.5209 | -0.7232 | -1.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.6164 | -0.6125 | -0.6771 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.67841 | 93.92 | -6.051 | -0.9815 | -0.2291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.076 | 2.330 | 1.286 | 0.6333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7647 | 1.488 | 1.374 | 1.343 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.67841</span> | 93.92 | 0.002355 | 0.2726 | 0.7952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.971 | 2.330 | 1.286 | 0.6333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7647 | 1.488 | 1.374 | 1.343 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 458.25487 | 1.002 | -1.469 | -0.8998 | -0.8789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8006 | -0.5263 | -0.7262 | -0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5942 | -0.6683 | -0.7117 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.25487 | 94.17 | -5.869 | -0.9787 | -0.1835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.148 | 2.325 | 1.285 | 0.6855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.514 | 1.313 | 1.304 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.25487</span> | 94.17 | 0.002825 | 0.2732 | 0.8324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.572 | 2.325 | 1.285 | 0.6855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.514 | 1.313 | 1.304 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 458.28425 | 1.002 | -1.442 | -0.8994 | -0.8721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7899 | -0.5271 | -0.7267 | -0.9564 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5910 | -0.6765 | -0.7168 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.28425 | 94.21 | -5.842 | -0.9783 | -0.1768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.159 | 2.324 | 1.284 | 0.6932 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.518 | 1.304 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.28425</span> | 94.21 | 0.002902 | 0.2732 | 0.8380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.664 | 2.324 | 1.284 | 0.6932 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.518 | 1.304 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 458.13208 | 0.9983 | -1.435 | -0.8993 | -0.8705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7874 | -0.5276 | -0.7266 | -0.9533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6785 | -0.7183 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.13208 | 93.84 | -5.835 | -0.9781 | -0.1751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.323 | 1.284 | 0.6955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7380 | 1.519 | 1.302 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.13208</span> | 93.84 | 0.002922 | 0.2733 | 0.8394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.686 | 2.323 | 1.284 | 0.6955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7380 | 1.519 | 1.302 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.75 | 0.2391 | 0.3431 | -0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6079 | -1.684 | 0.2301 | 1.587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9924 | -0.4675 | 0.3927 | -0.7567 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 458.12484 | 0.9973 | -1.435 | -0.8993 | -0.8705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7874 | -0.5275 | -0.7266 | -0.9535 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5900 | -0.6785 | -0.7182 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.12484 | 93.75 | -5.835 | -0.9782 | -0.1751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7379 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12484</span> | 93.75 | 0.002922 | 0.2733 | 0.8394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.686 | 2.324 | 1.284 | 0.6954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7379 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4576 | 0.2336 | 0.2904 | -0.1274 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6585 | -1.014 | 0.9040 | 1.932 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.695 | 0.2950 | 0.3980 | -0.7211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 458.12349 | 0.9975 | -1.436 | -0.8994 | -0.8704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7872 | -0.5272 | -0.7269 | -0.9542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -0.5901 | -0.6787 | -0.7180 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.12349 | 93.76 | -5.836 | -0.9783 | -0.1751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7384 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12349</span> | 93.76 | 0.002922 | 0.2732 | 0.8394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.688 | 2.324 | 1.284 | 0.6949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7384 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.734 | 0.2328 | 0.2907 | -0.1244 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6480 | -0.5259 | 1.203 | 2.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.687 | 0.2714 | 0.3976 | -0.7167 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 458.12069 | 0.9972 | -1.436 | -0.8995 | -0.8704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7868 | -0.5270 | -0.7278 | -0.9557 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5902 | -0.6785 | -0.7174 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.12069 | 93.74 | -5.836 | -0.9784 | -0.1750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6937 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12069</span> | 93.74 | 0.002921 | 0.2732 | 0.8394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.691 | 2.324 | 1.284 | 0.6937 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.995 | 0.2265 | 0.2648 | -0.1319 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6577 | -1.056 | 0.5532 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4851 | 0.2582 | 0.3806 | -0.6784 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 458.12793 | 0.9986 | -1.436 | -0.8997 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7863 | -0.5263 | -0.7282 | -0.9568 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7169 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.12793 | 93.87 | -5.836 | -0.9785 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6929 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12793</span> | 93.87 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.695 | 2.325 | 1.283 | 0.6929 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 458.12002 | 0.9975 | -1.436 | -0.8996 | -0.8704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7866 | -0.5269 | -0.7279 | -0.9559 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.5903 | -0.6786 | -0.7173 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.12002 | 93.77 | -5.836 | -0.9784 | -0.1750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.162 | 2.324 | 1.284 | 0.6935 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.12002</span> | 93.77 | 0.002921 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.692 | 2.324 | 1.284 | 0.6935 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7392 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.647 | 0.2293 | 0.2815 | -0.1267 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6372 | -0.9129 | 0.8290 | 1.823 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.624 | 0.2659 | 0.4184 | -0.6478 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 458.11922 | 0.9973 | -1.436 | -0.8996 | -0.8704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7866 | -0.5268 | -0.7280 | -0.9563 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5903 | -0.6786 | -0.7171 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11922 | 93.74 | -5.836 | -0.9784 | -0.1750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.324 | 1.284 | 0.6933 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7394 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11922</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.693 | 2.324 | 1.284 | 0.6933 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7394 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8024 | 0.2274 | 0.2665 | -0.1307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6475 | -1.019 | 0.5594 | 1.618 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.681 | 0.3232 | 0.3907 | -0.6658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 458.11869 | 0.9974 | -1.436 | -0.8996 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7864 | -0.5266 | -0.7281 | -0.9565 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6787 | -0.7170 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11869 | 93.76 | -5.836 | -0.9785 | -0.1750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.324 | 1.283 | 0.6931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11869</span> | 93.76 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.694 | 2.324 | 1.283 | 0.6931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.112 | 0.2271 | 0.2694 | -0.1286 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6401 | -1.529 | 0.3516 | 1.832 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3653 | 0.2635 | 0.3774 | -0.6589 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 458.11797 | 0.9972 | -1.436 | -0.8997 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7863 | -0.5263 | -0.7282 | -0.9569 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7169 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11797 | 93.74 | -5.836 | -0.9785 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11797</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.695 | 2.325 | 1.283 | 0.6928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7397 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.528 | 0.2260 | 0.2581 | -0.1311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6478 | -1.074 | 0.7096 | 1.705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.609 | 0.2690 | 0.3809 | -0.6419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 458.11744 | 0.9975 | -1.436 | -0.8997 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7862 | -0.5262 | -0.7283 | -0.9571 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5904 | -0.6788 | -0.7168 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11744 | 93.76 | -5.836 | -0.9786 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6926 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7399 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11744</span> | 93.76 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.696 | 2.325 | 1.283 | 0.6926 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7399 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.737 | 0.2262 | 0.2659 | -0.1276 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6346 | -0.9458 | 0.5100 | 1.567 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.640 | 0.3111 | 0.3526 | -0.6225 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 458.11714 | 0.9972 | -1.436 | -0.8998 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7861 | -0.5260 | -0.7284 | -0.9574 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5905 | -0.6789 | -0.7167 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11714 | 93.74 | -5.836 | -0.9786 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6924 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7402 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11714</span> | 93.74 | 0.002920 | 0.2732 | 0.8395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.697 | 2.325 | 1.283 | 0.6924 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7402 | 1.519 | 1.302 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.976 | 0.2241 | 0.2491 | -0.1309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6467 | -0.8649 | 0.8521 | 1.757 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.585 | 0.2641 | 0.3618 | -0.6092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 458.11663 | 0.9975 | -1.436 | -0.8998 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7860 | -0.5259 | -0.7285 | -0.9576 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5905 | -0.6789 | -0.7166 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11663 | 93.76 | -5.836 | -0.9787 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6923 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11663</span> | 93.76 | 0.002920 | 0.2732 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.698 | 2.325 | 1.283 | 0.6923 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.001 | 0.2249 | 0.2609 | -0.1271 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6310 | -0.8317 | 0.8110 | 1.745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3162 | 0.2564 | 0.3586 | -0.6097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 458.11610 | 0.9971 | -1.436 | -0.8999 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -0.5258 | -0.7286 | -0.9579 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6790 | -0.7165 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1161 | 93.73 | -5.836 | -0.9787 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.325 | 1.283 | 0.6920 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1161</span> | 93.73 | 0.002920 | 0.2732 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.699 | 2.325 | 1.283 | 0.6920 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7404 | 1.518 | 1.301 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.471 | 0.2228 | 0.2417 | -0.1310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6447 | -1.605 | 0.009434 | 1.531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.615 | 0.2909 | 0.3664 | -0.6093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 458.11531 | 0.9974 | -1.436 | -0.8999 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -0.5256 | -0.7287 | -0.9582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5905 | -0.6791 | -0.7164 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11531 | 93.76 | -5.836 | -0.9788 | -0.1749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6918 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7405 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11531</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.699 | 2.326 | 1.283 | 0.6918 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7405 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.540 | 0.2236 | 0.2522 | -0.1268 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6308 | -0.9638 | 0.7239 | 1.714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.540 | 0.2567 | 0.3599 | -0.5942 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 458.11496 | 0.9972 | -1.436 | -0.8999 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7858 | -0.5254 | -0.7288 | -0.9585 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6791 | -0.7163 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11496 | 93.74 | -5.836 | -0.9788 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6916 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7408 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11496</span> | 93.74 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.700 | 2.326 | 1.283 | 0.6916 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7408 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.772 | 0.2217 | 0.2376 | -0.1305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6412 | -1.736 | 0.1210 | 1.307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.540 | 0.2780 | 0.3483 | -0.5916 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 458.11458 | 0.9975 | -1.436 | -0.9000 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7857 | -0.5252 | -0.7289 | -0.9587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.5906 | -0.6792 | -0.7163 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11458 | 93.76 | -5.836 | -0.9788 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.163 | 2.326 | 1.283 | 0.6915 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7410 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11458</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.701 | 2.326 | 1.283 | 0.6915 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7410 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.896 | 0.2223 | 0.2476 | -0.1262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6268 | -0.4531 | 0.7600 | 1.698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.483 | 0.2984 | 0.3374 | -0.6006 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 458.11430 | 0.9972 | -1.436 | -0.9000 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7856 | -0.5251 | -0.7290 | -0.9589 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6792 | -0.7162 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1143 | 93.73 | -5.836 | -0.9789 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1143</span> | 93.73 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.702 | 2.326 | 1.283 | 0.6913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.121 | 0.2201 | 0.2306 | -0.1307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6392 | -0.8820 | 0.4853 | 1.475 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.568 | 0.2856 | 0.3442 | -0.5942 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 458.11392 | 0.9975 | -1.437 | -0.9001 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7855 | -0.5250 | -0.7290 | -0.9592 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6793 | -0.7161 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11392 | 93.76 | -5.837 | -0.9789 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6911 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11392</span> | 93.76 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.702 | 2.326 | 1.283 | 0.6911 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.218 | 0.2203 | 0.2415 | -0.1269 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6242 | -1.700 | -0.1298 | 1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.097 | -0.4639 | 0.3406 | -0.5940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 458.11292 | 0.9972 | -1.437 | -0.9001 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7854 | -0.5247 | -0.7291 | -0.9594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6794 | -0.7160 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11292 | 93.74 | -5.837 | -0.9790 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.326 | 1.283 | 0.6909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11292</span> | 93.74 | 0.002919 | 0.2731 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.703 | 2.326 | 1.283 | 0.6909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7412 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.114 | 0.2202 | 0.2288 | -0.1307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6328 | -0.7727 | 0.7964 | 1.664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2569 | 0.2827 | 0.3132 | -0.5835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 458.11219 | 0.9975 | -1.437 | -0.9002 | -0.8701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7853 | -0.5246 | -0.7293 | -0.9597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6795 | -0.7158 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11219 | 93.76 | -5.837 | -0.9790 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7413 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11219</span> | 93.76 | 0.002919 | 0.2731 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.704 | 2.327 | 1.283 | 0.6907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7413 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.924 | 0.2207 | 0.2357 | -0.1254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6202 | -0.4451 | 0.8288 | 1.643 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.561 | 0.2786 | 0.3167 | -0.5797 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 458.11161 | 0.9972 | -1.437 | -0.9002 | -0.8701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7852 | -0.5246 | -0.7295 | -0.9601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6795 | -0.7157 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11161 | 93.74 | -5.837 | -0.9791 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11161</span> | 93.74 | 0.002918 | 0.2731 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.705 | 2.327 | 1.283 | 0.6904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7414 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.221 | 0.2188 | 0.2217 | -0.1291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6301 | -1.629 | 0.1332 | 1.223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.491 | 0.2969 | 0.3215 | -0.5516 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 458.11130 | 0.9974 | -1.437 | -0.9003 | -0.8701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7851 | -0.5243 | -0.7295 | -0.9603 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6796 | -0.7156 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1113 | 93.76 | -5.837 | -0.9791 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6902 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1113</span> | 93.76 | 0.002918 | 0.2731 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.706 | 2.327 | 1.283 | 0.6902 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.605 | 0.2188 | 0.2279 | -0.1262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6191 | -1.596 | 0.1216 | 1.254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.158 | -0.4084 | 0.3005 | -0.5648 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 458.11059 | 0.9972 | -1.437 | -0.9003 | -0.8701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7850 | -0.5240 | -0.7295 | -0.9605 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6796 | -0.7155 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11059 | 93.73 | -5.837 | -0.9791 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7415 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11059</span> | 93.73 | 0.002918 | 0.2731 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.707 | 2.327 | 1.283 | 0.6901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7415 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.022 | 0.2179 | 0.2140 | -0.1317 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6294 | -0.4112 | 0.8588 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.524 | 0.3410 | 0.3226 | -0.5400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 458.10995 | 0.9975 | -1.437 | -0.9003 | -0.8701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7849 | -0.5239 | -0.7297 | -0.9608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6797 | -0.7154 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10995 | 93.76 | -5.837 | -0.9792 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.283 | 0.6899 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10995</span> | 93.76 | 0.002918 | 0.2731 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.708 | 2.327 | 1.283 | 0.6899 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7416 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.872 | 0.2188 | 0.2245 | -0.1278 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6141 | -1.055 | 0.5121 | 1.433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.504 | 0.3641 | 0.3235 | -0.5302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 458.10978 | 0.9972 | -1.437 | -0.9004 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7848 | -0.5238 | -0.7297 | -0.9610 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5907 | -0.6797 | -0.7153 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10978 | 93.73 | -5.837 | -0.9792 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.282 | 0.6897 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10978</span> | 93.73 | 0.002918 | 0.2730 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.709 | 2.327 | 1.282 | 0.6897 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.301 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.410 | 0.2142 | 0.1743 | -0.1457 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -0.7806 | 0.7426 | 1.188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06181 | -0.3659 | 0.5158 | -0.5913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 458.10914 | 0.9975 | -1.437 | -0.9004 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7847 | -0.5236 | -0.7299 | -0.9612 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5906 | -0.6798 | -0.7152 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10914 | 93.77 | -5.837 | -0.9792 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.327 | 1.282 | 0.6895 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10914</span> | 93.77 | 0.002918 | 0.2730 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.709 | 2.327 | 1.282 | 0.6895 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.690 | 0.2171 | 0.2203 | -0.1291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6099 | -0.7940 | 0.4528 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.452 | 0.2831 | 0.2911 | -0.5300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 458.10832 | 0.9972 | -1.437 | -0.9004 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7846 | -0.5235 | -0.7300 | -0.9615 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5905 | -0.6799 | -0.7151 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10832 | 93.74 | -5.837 | -0.9793 | -0.1747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.164 | 2.328 | 1.282 | 0.6893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10832</span> | 93.74 | 0.002918 | 0.2730 | 0.8397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.710 | 2.328 | 1.282 | 0.6893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.386 | 0.2164 | 0.2066 | -0.1317 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6210 | -0.6390 | 0.8493 | 1.598 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.491 | 0.2964 | 0.2278 | -0.4988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 458.10801 | 0.9974 | -1.437 | -0.9005 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7845 | -0.5234 | -0.7302 | -0.9618 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5906 | -0.6800 | -0.7150 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10801 | 93.76 | -5.837 | -0.9793 | -0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10801</span> | 93.76 | 0.002918 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.711 | 2.328 | 1.282 | 0.6891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.854 | 0.2167 | 0.2150 | -0.1282 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6083 | -0.7461 | 0.7029 | 1.539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1981 | 0.2733 | 0.2717 | -0.5257 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 458.10765 | 0.9971 | -1.437 | -0.9005 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7844 | -0.5232 | -0.7303 | -0.9621 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5906 | -0.6800 | -0.7149 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10765 | 93.73 | -5.837 | -0.9794 | -0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10765</span> | 93.73 | 0.002917 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.712 | 2.328 | 1.282 | 0.6889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.678 | 0.2148 | 0.1964 | -0.1329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6222 | -0.7140 | 0.5004 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2647 | 0.3470 | 0.3026 | -0.5041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 458.10677 | 0.9974 | -1.437 | -0.9006 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7843 | -0.5231 | -0.7305 | -0.9624 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7148 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10677 | 93.76 | -5.837 | -0.9794 | -0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6887 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10677</span> | 93.76 | 0.002917 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.713 | 2.328 | 1.282 | 0.6887 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.911 | 0.2164 | 0.2105 | -0.1281 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6034 | -0.7920 | 0.6471 | 1.488 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2445 | 0.2110 | 0.2380 | -0.4469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 458.10609 | 0.9972 | -1.437 | -0.9006 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7842 | -0.5230 | -0.7306 | -0.9627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7147 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10609 | 93.74 | -5.837 | -0.9794 | -0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10609</span> | 93.74 | 0.002917 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.714 | 2.328 | 1.282 | 0.6884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.518 | 1.300 | 1.300 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.589 | 0.2148 | 0.1951 | -0.1322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6145 | -0.8575 | 0.5942 | 1.427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.492 | 0.2699 | 0.1872 | -0.4796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 458.10567 | 0.9974 | -1.437 | -0.9006 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7841 | -0.5228 | -0.7308 | -0.9630 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7146 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10567 | 93.76 | -5.837 | -0.9795 | -0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10567</span> | 93.76 | 0.002917 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.715 | 2.328 | 1.282 | 0.6882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.760 | 0.2153 | 0.2043 | -0.1283 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6005 | -0.7529 | 0.6292 | 1.454 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2107 | 0.2534 | 0.2280 | -0.4318 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 458.10540 | 0.9971 | -1.437 | -0.9007 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7840 | -0.5227 | -0.7309 | -0.9633 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7146 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1054 | 93.73 | -5.837 | -0.9795 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.328 | 1.282 | 0.6880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1054</span> | 93.73 | 0.002917 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.716 | 2.328 | 1.282 | 0.6880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.789 | 0.2130 | 0.1850 | -0.1339 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6160 | -0.6903 | 0.7130 | 1.481 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1975 | 0.2824 | 0.2646 | -0.4868 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 458.10444 | 0.9974 | -1.437 | -0.9007 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7839 | -0.5226 | -0.7311 | -0.9636 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6801 | -0.7145 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10444 | 93.76 | -5.837 | -0.9796 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10444</span> | 93.76 | 0.002916 | 0.2730 | 0.8398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.717 | 2.329 | 1.282 | 0.6878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.285 | 0.2143 | 0.1972 | -0.1290 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5987 | -0.7355 | 0.6064 | 1.421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.460 | 0.2526 | 0.2188 | -0.4206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 458.10435 | 0.9972 | -1.437 | -0.9008 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7838 | -0.5224 | -0.7312 | -0.9638 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6802 | -0.7144 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10435 | 93.73 | -5.837 | -0.9796 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6876 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10435</span> | 93.73 | 0.002916 | 0.2730 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.718 | 2.329 | 1.282 | 0.6876 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7425 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.184 | 0.2097 | 0.1486 | -0.1446 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6255 | -0.7028 | 0.6444 | 1.495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.416 | 0.3010 | 0.4942 | -0.5303 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 458.10393 | 0.9975 | -1.438 | -0.9008 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7837 | -0.5223 | -0.7313 | -0.9641 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6802 | -0.7143 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10393 | 93.76 | -5.838 | -0.9796 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.165 | 2.329 | 1.282 | 0.6873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7426 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10393</span> | 93.76 | 0.002916 | 0.2730 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.718 | 2.329 | 1.282 | 0.6873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7426 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.045 | 0.2119 | 0.1940 | -0.1305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5955 | -0.7252 | 0.6285 | 1.413 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2070 | 0.2194 | 0.2208 | -0.3980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 458.10364 | 0.9971 | -1.438 | -0.9008 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7836 | -0.5222 | -0.7314 | -0.9644 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6803 | -0.7142 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10364 | 93.73 | -5.838 | -0.9796 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10364</span> | 93.73 | 0.002916 | 0.2730 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.719 | 2.329 | 1.281 | 0.6871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.727 | 0.2108 | 0.1771 | -0.1339 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6094 | -0.7304 | 0.6317 | 1.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.443 | 0.2644 | 0.2580 | -0.4629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 458.10286 | 0.9974 | -1.438 | -0.9008 | -0.8699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7835 | -0.5221 | -0.7316 | -0.9647 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5908 | -0.6803 | -0.7141 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10286 | 93.75 | -5.838 | -0.9796 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10286</span> | 93.75 | 0.002915 | 0.2730 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.720 | 2.329 | 1.281 | 0.6869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.225 | 0.2118 | 0.1898 | -0.1294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5932 | -0.6493 | 0.6517 | 1.411 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1402 | 0.3233 | 0.2428 | -0.3732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 458.10253 | 0.9971 | -1.438 | -0.9009 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7834 | -0.5219 | -0.7318 | -0.9650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6803 | -0.7141 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10253 | 93.73 | -5.838 | -0.9797 | -0.1745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10253</span> | 93.73 | 0.002915 | 0.2730 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.721 | 2.329 | 1.281 | 0.6867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.449 | 0.2099 | 0.1736 | -0.1338 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | -0.7015 | 0.6330 | 1.384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1863 | 0.2615 | 0.2563 | -0.4532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 458.10167 | 0.9974 | -1.438 | -0.9009 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7832 | -0.5218 | -0.7320 | -0.9653 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7140 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10167 | 93.76 | -5.838 | -0.9797 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10167</span> | 93.76 | 0.002915 | 0.2729 | 0.8399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.722 | 2.329 | 1.281 | 0.6864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.422 | 0.2110 | 0.1849 | -0.1293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5889 | -0.5964 | 0.6731 | 1.405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1535 | 0.3114 | 0.2496 | -0.4521 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 458.10133 | 0.9971 | -1.438 | -0.9009 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7831 | -0.5217 | -0.7321 | -0.9657 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7139 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10133 | 93.73 | -5.838 | -0.9798 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.329 | 1.281 | 0.6862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10133</span> | 93.73 | 0.002915 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.723 | 2.329 | 1.281 | 0.6862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.461 | 0.2094 | 0.1688 | -0.1332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6003 | -0.7109 | 0.5914 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.404 | 0.2951 | 0.2552 | -0.4331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 458.10059 | 0.9974 | -1.438 | -0.9009 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7830 | -0.5215 | -0.7323 | -0.9660 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6804 | -0.7138 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10059 | 93.75 | -5.838 | -0.9798 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10059</span> | 93.75 | 0.002915 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.724 | 2.330 | 1.281 | 0.6860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.228 | 0.2101 | 0.1802 | -0.1294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5857 | -0.2287 | 0.9339 | 1.558 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.376 | 0.3488 | 0.2665 | -0.4324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 458.10050 | 0.9972 | -1.438 | -0.9010 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7829 | -0.5215 | -0.7325 | -0.9663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5910 | -0.6804 | -0.7137 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.1005 | 93.73 | -5.838 | -0.9798 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.1005</span> | 93.73 | 0.002915 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.725 | 2.330 | 1.281 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -2.045 | 0.2058 | 0.1327 | -0.1461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6105 | -0.6040 | 0.6130 | 0.9518 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01902 | 0.3702 | 0.4676 | -0.4886 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 458.10013 | 0.9974 | -1.438 | -0.9010 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7829 | -0.5214 | -0.7325 | -0.9664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5910 | -0.6805 | -0.7136 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10013 | 93.75 | -5.838 | -0.9798 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10013</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.725 | 2.330 | 1.281 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.8557 | 0.2088 | 0.1747 | -0.1300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5847 | -0.2393 | 0.9114 | 1.536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.367 | 0.3016 | 0.2557 | -0.4123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 458.10002 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7828 | -0.5214 | -0.7326 | -0.9665 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6805 | -0.7136 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.10002 | 93.74 | -5.838 | -0.9798 | -0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7432 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.10002</span> | 93.74 | 0.002914 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.726 | 2.330 | 1.281 | 0.6856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7432 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.5131 | 0.2058 | 0.1358 | -0.1441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6029 | -0.6262 | 0.5998 | 1.158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.373 | 0.3470 | 0.4566 | -0.4872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 458.09992 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7827 | -0.5214 | -0.7327 | -0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6806 | -0.7135 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.09992 | 93.75 | -5.838 | -0.9799 | -0.1743 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7433 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09992</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.726 | 2.330 | 1.281 | 0.6855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7433 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.2584 | 0.2056 | 0.1371 | -0.1438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5991 | -0.6198 | 0.6082 | 0.9676 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.295 | 0.3221 | 0.4533 | -0.4750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 458.09944 | 0.9973 | -1.438 | -0.9010 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7827 | -0.5213 | -0.7328 | -0.9668 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6806 | -0.7135 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.09944 | 93.75 | -5.838 | -0.9799 | -0.1743 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.166 | 2.330 | 1.281 | 0.6854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7431 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09944</span> | 93.75 | 0.002914 | 0.2729 | 0.8400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.727 | 2.330 | 1.281 | 0.6854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7431 | 1.518 | 1.300 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 458.09825 | 0.9974 | -1.438 | -0.9011 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7824 | -0.5210 | -0.7332 | -0.9672 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.5911 | -0.6808 | -0.7131 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.09825 | 93.76 | -5.838 | -0.9799 | -0.1743 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.167 | 2.330 | 1.280 | 0.6851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.299 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09825</span> | 93.76 | 0.002914 | 0.2729 | 0.8401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.729 | 2.330 | 1.280 | 0.6851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7430 | 1.518 | 1.299 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 458.09793 | 0.9981 | -1.438 | -0.9013 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7815 | -0.5202 | -0.7349 | -0.9686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5909 | -0.6812 | -0.7117 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.09793 | 93.82 | -5.838 | -0.9801 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.168 | 2.331 | 1.279 | 0.6840 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.299 | 1.304 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.09793</span> | 93.82 | 0.002913 | 0.2729 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.737 | 2.331 | 1.279 | 0.6840 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7428 | 1.518 | 1.299 | 1.304 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.76 | 0.2116 | 0.1923 | -0.1162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5255 | -0.5796 | 0.3777 | 1.210 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.409 | 0.2855 | 0.1875 | -0.3085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 458.08987 | 0.9971 | -1.438 | -0.9013 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7808 | -0.5187 | -0.7369 | -0.9692 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5907 | -0.6832 | -0.7095 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08987 | 93.72 | -5.838 | -0.9802 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.168 | 2.332 | 1.278 | 0.6836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.297 | 1.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08987</span> | 93.72 | 0.002914 | 0.2729 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.743 | 2.332 | 1.278 | 0.6836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7427 | 1.518 | 1.297 | 1.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.512 | 0.2078 | 0.1434 | -0.1372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5667 | -0.8061 | 0.1467 | 1.033 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.202 | -0.4065 | 0.09417 | -0.1935 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 458.08564 | 0.9973 | -1.438 | -0.9016 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7801 | -0.5170 | -0.7384 | -0.9704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5898 | -0.6859 | -0.7082 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08564 | 93.74 | -5.838 | -0.9804 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.169 | 2.334 | 1.277 | 0.6827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.519 | 1.294 | 1.308 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08564</span> | 93.74 | 0.002914 | 0.2728 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.749 | 2.334 | 1.277 | 0.6827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.519 | 1.294 | 1.308 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 458.08078 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7788 | -0.5136 | -0.7416 | -0.9727 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5879 | -0.6916 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08078 | 93.73 | -5.838 | -0.9809 | -0.1742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.522 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08078</span> | 93.73 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.761 | 2.338 | 1.275 | 0.6809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.522 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8456 | 0.2109 | 0.1052 | -0.1453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5381 | -0.2225 | -0.1274 | 0.8336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2653 | 0.4698 | -0.4321 | 0.07917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 458.08109 | 0.9983 | -1.445 | -0.9066 | -0.8702 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7727 | -0.5143 | -0.7362 | -0.9770 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.5885 | -0.6915 | -0.7058 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08109 | 93.84 | -5.845 | -0.9853 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.176 | 2.337 | 1.279 | 0.6777 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.521 | 1.288 | 1.310 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08109</span> | 93.84 | 0.002894 | 0.2718 | 0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.815 | 2.337 | 1.279 | 0.6777 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7418 | 1.521 | 1.288 | 1.310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 458.08775 | 0.9985 | -1.441 | -0.9040 | -0.8696 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7757 | -0.5136 | -0.7393 | -0.9753 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5887 | -0.6911 | -0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08775 | 93.86 | -5.841 | -0.9828 | -0.1743 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.173 | 2.338 | 1.277 | 0.6789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08775</span> | 93.86 | 0.002906 | 0.2723 | 0.8401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.788 | 2.338 | 1.277 | 0.6789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 458.08407 | 0.9980 | -1.438 | -0.9022 | -0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7783 | -0.5133 | -0.7415 | -0.9736 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5884 | -0.6912 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08407 | 93.81 | -5.838 | -0.9810 | -0.1740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08407</span> | 93.81 | 0.002915 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.766 | 2.338 | 1.275 | 0.6802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 458.08069 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08069 | 93.75 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08069</span> | 93.75 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.424 | 0.2112 | 0.1114 | -0.1426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5267 | -0.3290 | -0.02249 | 0.9218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.516 | 0.4273 | -0.4325 | 0.09748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 458.08076 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5134 | -0.7416 | -0.9730 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6914 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08076 | 93.74 | -5.838 | -0.9810 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08076</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 458.08078 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9730 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08078 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08078</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 458.08068 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08068 | 93.75 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08068</span> | 93.75 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.7458 | 0.2086 | 0.07146 | -0.1568 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5453 | -0.1723 | 0.1066 | 0.6006 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05957 | 0.1717 | -0.3314 | 0.06442 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 458.08065 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7787 | -0.5135 | -0.7416 | -0.9729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08065 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08065</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.5271 | 0.2085 | 0.07055 | -0.1570 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5454 | -0.3138 | 0.09492 | 0.7765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.192 | 0.4934 | -0.3382 | 0.1071 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 458.08062 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9730 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5880 | -0.6915 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08062 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08062</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.762 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7420 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.1077 | 0.2083 | 0.06880 | -0.1572 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5469 | -0.1727 | 0.1219 | 0.9565 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.457 | 0.5128 | -0.3399 | 0.1022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 458.08061 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9730 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08061 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.170 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08061</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.6930 | 0.2078 | 0.06712 | -0.1577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5484 | -0.1767 | 0.1148 | 0.9863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2038 | 0.5855 | -0.3296 | 0.1002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 458.08058 | 0.9972 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7786 | -0.5135 | -0.7416 | -0.9731 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08058 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08058</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.3701 | 0.2079 | 0.06808 | -0.1573 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5470 | -0.1729 | 0.005725 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.465 | 0.5101 | -0.1466 | -0.02770 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 458.08052 | 0.9973 | -1.438 | -0.9021 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7785 | -0.5135 | -0.7416 | -0.9731 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5881 | -0.6914 | -0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08052 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08052</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.763 | 2.338 | 1.275 | 0.6806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.2062 | 0.2080 | 0.06837 | -0.1566 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | -0.1704 | 0.09858 | 0.5928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05984 | 0.5131 | -0.3447 | 0.06046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 458.08047 | 0.9972 | -1.438 | -0.9021 | -0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7785 | -0.5134 | -0.7416 | -0.9732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5882 | -0.6914 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08047 | 93.74 | -5.838 | -0.9809 | -0.1741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08047</span> | 93.74 | 0.002915 | 0.2727 | 0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.764 | 2.338 | 1.275 | 0.6805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.06148 | 0.2077 | 0.06828 | -0.1566 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5434 | -0.1748 | 0.1045 | 0.7316 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7607 | 0.4924 | -0.3350 | 0.1046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 458.08041 | 0.9972 | -1.438 | -0.9021 | -0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7784 | -0.5134 | -0.7417 | -0.9733 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5883 | -0.6913 | -0.7054 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08041 | 93.74 | -5.838 | -0.9810 | -0.1740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6804 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08041</span> | 93.74 | 0.002915 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.765 | 2.338 | 1.275 | 0.6804 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7421 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.5076 | 0.2073 | 0.06528 | -0.1564 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5454 | -0.1802 | 0.1061 | 0.9740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1992 | 0.5430 | -0.2714 | 0.1031 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 458.08026 | 0.9972 | -1.438 | -0.9022 | -0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7782 | -0.5133 | -0.7417 | -0.9736 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5884 | -0.6912 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08026 | 93.74 | -5.838 | -0.9810 | -0.1740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08026</span> | 93.74 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.766 | 2.338 | 1.275 | 0.6802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7422 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.3779 | 0.2092 | 0.07455 | -0.1547 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5349 | 0.4172 | -0.5362 | 0.7903 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.451 | 0.5182 | -0.2163 | -0.4361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 458.08039 | 0.9975 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7778 | -0.5133 | -0.7416 | -0.9742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5887 | -0.6910 | -0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08039 | 93.76 | -5.838 | -0.9811 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08039</span> | 93.76 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.769 | 2.338 | 1.275 | 0.6798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 458.08025 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08025 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08025</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 1.019 | 0.2066 | 0.06601 | -0.1530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5270 | -0.1637 | 0.1163 | 0.9184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.439 | 0.4715 | -0.2217 | 0.03756 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 458.08029 | 0.9972 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 458.08025 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08025 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08025</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7424 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 458.08029 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 458.08024 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08024 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08024</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.9275 | 0.2065 | 0.06562 | -0.1530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5278 | -0.1682 | 0.1168 | 0.9523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1838 | 0.4888 | -0.3154 | 0.09539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 458.08024 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08024 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08024</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.8715 | 0.2065 | 0.06540 | -0.1531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5308 | -0.07756 | 0.1164 | 0.5595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04465 | -0.2577 | -0.3240 | 0.1066 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 458.08023 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08023 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08023</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 458.08013 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08013 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08013</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.7255 | 0.2064 | 0.06482 | -0.1531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5283 | -0.1617 | 0.1081 | 0.9192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.441 | 0.4906 | -0.2900 | 0.1161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 458.08017 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5885 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08017 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08017</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 458.08021 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08021 | 93.74 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08021</span> | 93.74 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 458.08029 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08029 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08029</span> | 93.75 | 0.002914 | 0.2727 | 0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 458.08033 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08033 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08033</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 458.08032 | 0.9973 | -1.438 | -0.9022 | -0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7780 | -0.5133 | -0.7416 | -0.9739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.5886 | -0.6911 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.08032 | 93.75 | -5.838 | -0.9810 | -0.1739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.171 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.08032</span> | 93.75 | 0.002914 | 0.2727 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.768 | 2.338 | 1.275 | 0.6800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7423 | 1.521 | 1.288 | 1.311 |</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> 1: 93.0952 -5.6337 -1.8988 -4.1294 -1.2035 0.1038 5.2152 1.6150 1.0450 2.6377 0.5035 0.5225 20.0768 11.4566</span> -<span class="r-out co"><span class="r-pr">#></span> 2: 93.1464 -5.6948 -1.8729 -4.2029 -1.1302 0.1295 5.5478 1.5342 0.9927 2.5059 0.4783 0.5147 11.2089 8.1577</span> -<span class="r-out co"><span class="r-pr">#></span> 3: 93.1719 -5.7029 -1.8810 -4.2024 -1.0686 0.1063 5.2764 1.5217 0.9431 2.3806 0.4544 0.5587 9.3753 5.7166</span> -<span class="r-out co"><span class="r-pr">#></span> 4: 92.8647 -5.8139 -1.8979 -4.1992 -1.0168 0.1122 5.4892 1.7893 0.8960 2.2615 0.4317 0.5307 9.4134 4.7166</span> -<span class="r-out co"><span class="r-pr">#></span> 5: 92.7759 -5.8627 -1.8873 -4.1402 -1.0347 0.1243 6.2028 2.1819 0.8795 2.1485 0.4101 0.5042 9.5964 4.7340</span> -<span class="r-out co"><span class="r-pr">#></span> 6: 92.8080 -5.8954 -1.9186 -4.1772 -0.9727 0.1311 5.8926 2.0728 0.8633 2.0410 0.3896 0.4790 8.7334 4.1957</span> -<span class="r-out co"><span class="r-pr">#></span> 7: 92.9042 -5.9034 -1.9603 -4.1854 -0.9717 0.1630 5.5980 2.2068 0.8672 1.9390 0.3701 0.4550 8.7213 3.3409</span> -<span class="r-out co"><span class="r-pr">#></span> 8: 92.9302 -5.8545 -1.9240 -4.2343 -0.9748 0.1686 5.3181 2.3934 0.8239 1.9533 0.3516 0.4323 7.6950 2.9174</span> -<span class="r-out co"><span class="r-pr">#></span> 9: 92.9518 -5.5561 -1.9734 -4.1856 -0.9322 0.2129 5.0522 2.2738 0.7830 2.0138 0.3340 0.4689 7.9230 2.1930</span> -<span class="r-out co"><span class="r-pr">#></span> 10: 93.0672 -5.5564 -1.9633 -4.1456 -0.9343 0.2049 4.7996 2.1601 0.7438 2.0517 0.3173 0.4771 8.0644 2.0682</span> -<span class="r-out co"><span class="r-pr">#></span> 11: 92.6849 -5.6187 -1.9773 -4.1793 -0.9342 0.2290 4.5596 2.0521 0.7123 2.0774 0.3015 0.5052 8.2355 1.9349</span> -<span class="r-out co"><span class="r-pr">#></span> 12: 92.6425 -5.6989 -2.0144 -4.1395 -0.9342 0.2669 4.3316 2.2634 0.7142 2.3008 0.2864 0.5728 7.5188 1.8028</span> -<span class="r-out co"><span class="r-pr">#></span> 13: 92.2996 -5.6700 -1.9885 -4.0443 -0.9202 0.2750 4.5787 2.1608 0.7019 2.7515 0.2721 0.6641 7.0744 1.8958</span> -<span class="r-out co"><span class="r-pr">#></span> 14: 92.2457 -5.5825 -2.0314 -3.9788 -0.9142 0.2908 6.3744 2.0527 0.7018 3.2703 0.2585 0.6387 6.9499 1.8421</span> -<span class="r-out co"><span class="r-pr">#></span> 15: 92.1741 -5.5333 -2.0318 -3.9664 -0.9059 0.2894 6.0557 1.9501 0.7179 3.2869 0.2455 0.6068 7.0951 1.6824</span> -<span class="r-out co"><span class="r-pr">#></span> 16: 92.5772 -5.4982 -2.0352 -3.9471 -0.9063 0.2930 5.7529 1.8526 0.7244 3.6994 0.2333 0.5764 7.2138 1.7042</span> -<span class="r-out co"><span class="r-pr">#></span> 17: 92.7024 -5.4902 -2.0438 -4.0347 -0.9079 0.2959 5.4652 1.7600 0.7393 3.5144 0.2216 0.5765 7.0258 1.6793</span> -<span class="r-out co"><span class="r-pr">#></span> 18: 92.0240 -5.5539 -2.0520 -3.9601 -0.9079 0.2884 6.5142 1.9232 0.7320 3.9052 0.2157 0.5521 7.2568 1.6151</span> -<span class="r-out co"><span class="r-pr">#></span> 19: 92.6532 -5.6325 -2.0456 -3.9091 -0.9179 0.3047 6.5743 2.3363 0.7405 4.5825 0.2049 0.5425 7.6201 1.6565</span> -<span class="r-out co"><span class="r-pr">#></span> 20: 92.3488 -5.6617 -2.0554 -3.9501 -0.9216 0.3056 6.7080 2.7562 0.7218 4.7569 0.2083 0.5432 7.3481 1.8059</span> -<span class="r-out co"><span class="r-pr">#></span> 21: 92.5679 -5.7469 -2.0614 -4.0829 -0.8890 0.3158 6.6510 3.1993 0.7136 4.5191 0.1978 0.5281 7.3723 1.7461</span> -<span class="r-out co"><span class="r-pr">#></span> 22: 92.4785 -5.9527 -2.0657 -4.0580 -0.8971 0.3084 6.3184 4.1791 0.7144 4.2931 0.1929 0.5157 7.1922 1.6984</span> -<span class="r-out co"><span class="r-pr">#></span> 23: 92.5594 -5.8590 -2.0723 -4.0580 -0.9020 0.2952 6.0025 3.9702 0.7335 4.0784 0.1833 0.5129 7.7560 1.6302</span> -<span class="r-out co"><span class="r-pr">#></span> 24: 92.6152 -5.9488 -2.0658 -4.1187 -0.9050 0.2997 5.7024 4.5381 0.7215 3.8745 0.1875 0.5129 7.6182 1.6362</span> -<span class="r-out co"><span class="r-pr">#></span> 25: 92.4658 -5.8715 -2.0791 -4.0949 -0.8922 0.3074 6.1428 4.3112 0.7353 3.6808 0.1896 0.5157 7.2703 1.5633</span> -<span class="r-out co"><span class="r-pr">#></span> 26: 92.2507 -5.9797 -2.0707 -4.0834 -0.8868 0.3266 6.4124 4.7125 0.7334 3.5368 0.1851 0.5217 7.3085 1.5828</span> -<span class="r-out co"><span class="r-pr">#></span> 27: 92.7055 -5.9792 -2.0779 -4.2066 -0.8887 0.2993 6.0918 4.8624 0.7659 3.7456 0.1841 0.4956 7.3534 1.5240</span> -<span class="r-out co"><span class="r-pr">#></span> 28: 92.3971 -6.0253 -2.0648 -4.1406 -0.9042 0.2897 5.7872 4.7690 0.7449 3.5583 0.1823 0.4709 7.2479 1.5008</span> -<span class="r-out co"><span class="r-pr">#></span> 29: 92.4045 -5.9045 -2.0730 -4.1407 -0.8969 0.3103 5.6683 4.5306 0.7349 3.3816 0.1849 0.5054 7.1719 1.6004</span> -<span class="r-out co"><span class="r-pr">#></span> 30: 92.1714 -5.8598 -2.0645 -4.0913 -0.8964 0.2743 5.3849 4.3040 0.7538 3.3509 0.1757 0.4801 7.3739 1.5736</span> -<span class="r-out co"><span class="r-pr">#></span> 31: 91.9134 -5.7867 -2.0367 -4.0563 -0.8957 0.2280 5.1156 4.0888 0.7299 3.3452 0.1749 0.4673 6.5991 1.5909</span> -<span class="r-out co"><span class="r-pr">#></span> 32: 92.3743 -5.9967 -2.0255 -4.0668 -0.9025 0.2247 4.8599 4.6666 0.7256 3.3271 0.1714 0.5008 6.4693 1.5458</span> -<span class="r-out co"><span class="r-pr">#></span> 33: 92.5239 -5.9301 -2.0387 -4.0365 -0.9033 0.2558 4.6169 4.4333 0.7492 3.6109 0.1688 0.5424 6.7730 1.5771</span> -<span class="r-out co"><span class="r-pr">#></span> 34: 92.6892 -6.1135 -2.0587 -4.0280 -0.8993 0.2430 4.3860 6.0227 0.7798 3.5725 0.1672 0.5153 6.8110 1.5417</span> -<span class="r-out co"><span class="r-pr">#></span> 35: 92.7276 -6.0815 -2.0629 -4.0833 -0.8943 0.2375 4.6811 5.7216 0.8010 3.3939 0.1715 0.4895 6.6812 1.5478</span> -<span class="r-out co"><span class="r-pr">#></span> 36: 92.7316 -6.0691 -2.0882 -4.0626 -0.9030 0.2405 4.4614 5.4355 0.8355 3.2242 0.1789 0.4650 6.8443 1.4806</span> -<span class="r-out co"><span class="r-pr">#></span> 37: 92.6685 -5.7905 -2.0666 -4.0663 -0.8998 0.2784 5.1916 5.1637 0.7937 3.0641 0.1823 0.4418 6.5421 1.6284</span> -<span class="r-out co"><span class="r-pr">#></span> 38: 93.0325 -5.6829 -2.0674 -4.0772 -0.9167 0.2499 4.9320 4.9055 0.7768 3.1213 0.1887 0.4290 6.8220 1.5224</span> -<span class="r-out co"><span class="r-pr">#></span> 39: 93.0378 -5.5554 -2.0743 -4.0772 -0.9189 0.2361 4.6854 4.6603 0.7822 3.1213 0.1813 0.4242 7.1137 1.5021</span> -<span class="r-out co"><span class="r-pr">#></span> 40: 93.3297 -5.6270 -2.0591 -4.1200 -0.9167 0.2035 4.4511 4.4272 0.8128 2.9653 0.1829 0.4030 7.3894 1.5064</span> -<span class="r-out co"><span class="r-pr">#></span> 41: 93.3408 -5.5437 -2.0344 -4.1042 -0.9078 0.1744 4.2286 4.2059 0.8228 2.8170 0.1881 0.3829 7.2734 1.5519</span> -<span class="r-out co"><span class="r-pr">#></span> 42: 93.1691 -5.4436 -2.0551 -4.1048 -0.8984 0.1732 4.0172 3.9956 0.7816 2.6762 0.1853 0.3637 6.9712 1.5332</span> -<span class="r-out co"><span class="r-pr">#></span> 43: 93.2443 -5.5247 -2.0722 -4.0980 -0.8992 0.1756 3.8163 3.7958 0.7781 2.7200 0.1956 0.3455 6.7012 1.5344</span> -<span class="r-out co"><span class="r-pr">#></span> 44: 92.9509 -5.5020 -2.0495 -4.0961 -0.8964 0.1777 3.6255 3.6060 0.7555 2.8172 0.1994 0.3283 6.2180 1.6137</span> -<span class="r-out co"><span class="r-pr">#></span> 45: 92.8898 -5.4913 -2.0462 -4.1079 -0.9003 0.1701 4.1177 3.4257 0.7491 2.8491 0.1989 0.3372 6.2876 1.6205</span> -<span class="r-out co"><span class="r-pr">#></span> 46: 92.6044 -5.6429 -2.0499 -4.1079 -0.9069 0.1999 4.2103 3.2544 0.7657 2.8491 0.1921 0.3532 6.2261 1.6435</span> -<span class="r-out co"><span class="r-pr">#></span> 47: 92.7740 -5.6128 -2.0804 -4.1186 -0.8976 0.1864 5.2188 3.0917 0.7381 2.9036 0.2030 0.3391 6.6803 1.6177</span> -<span class="r-out co"><span class="r-pr">#></span> 48: 92.4691 -5.6645 -2.0600 -4.1288 -0.8796 0.1913 6.2045 2.9371 0.7774 2.9223 0.1966 0.3396 6.7169 1.6215</span> -<span class="r-out co"><span class="r-pr">#></span> 49: 92.4128 -5.7079 -2.0802 -4.1166 -0.8798 0.1741 5.8943 3.1446 0.7854 2.8715 0.1935 0.3369 6.9151 1.4834</span> -<span class="r-out co"><span class="r-pr">#></span> 50: 91.8883 -5.7713 -2.0932 -4.0899 -0.8886 0.1758 5.5996 3.5478 0.8033 2.8192 0.2014 0.3201 7.0775 1.4635</span> -<span class="r-out co"><span class="r-pr">#></span> 51: 92.1187 -5.7306 -2.0903 -4.0878 -0.8923 0.2024 5.3196 3.6534 0.7823 2.7891 0.1969 0.3140 6.9879 1.5430</span> -<span class="r-out co"><span class="r-pr">#></span> 52: 92.3209 -5.7897 -2.0903 -4.1622 -0.9072 0.2261 5.3781 3.4707 0.8001 3.0801 0.2063 0.3088 6.7047 1.4499</span> -<span class="r-out co"><span class="r-pr">#></span> 53: 92.4318 -5.6954 -2.0950 -4.1866 -0.9082 0.2131 7.1200 3.2972 0.7711 3.3398 0.2034 0.3186 6.6152 1.5123</span> -<span class="r-out co"><span class="r-pr">#></span> 54: 92.5380 -5.6975 -2.0782 -4.2394 -0.8976 0.2118 6.7640 3.1323 0.7744 3.5385 0.2175 0.3296 6.4402 1.5403</span> -<span class="r-out co"><span class="r-pr">#></span> 55: 92.7213 -5.6663 -2.0427 -4.3288 -0.9028 0.2032 8.1796 2.9757 0.7748 4.4495 0.2142 0.3316 6.4111 1.5369</span> -<span class="r-out co"><span class="r-pr">#></span> 56: 92.7219 -5.6865 -2.0557 -4.3434 -0.9084 0.2021 7.7706 2.8269 0.7989 4.6691 0.2174 0.3433 6.4256 1.4639</span> -<span class="r-out co"><span class="r-pr">#></span> 57: 92.8932 -5.5736 -2.0497 -4.3955 -0.9216 0.1694 7.3821 2.6856 0.8205 4.9791 0.2142 0.3500 6.5378 1.5406</span> -<span class="r-out co"><span class="r-pr">#></span> 58: 92.9219 -5.5789 -2.0547 -4.3094 -0.9183 0.1838 7.0130 2.5513 0.7958 4.7302 0.2193 0.3495 6.2662 1.4940</span> -<span class="r-out co"><span class="r-pr">#></span> 59: 93.0432 -5.6201 -2.0395 -4.2527 -0.9199 0.2302 6.6623 2.4237 0.8241 4.4937 0.2241 0.3321 5.8693 1.6176</span> -<span class="r-out co"><span class="r-pr">#></span> 60: 92.9724 -5.5971 -2.0537 -4.3509 -0.9219 0.2118 7.5905 2.3026 0.8418 4.4546 0.2177 0.3155 5.5960 1.5040</span> -<span class="r-out co"><span class="r-pr">#></span> 61: 93.1235 -5.6332 -2.0671 -4.3572 -0.9219 0.1917 7.2521 2.3037 0.8527 4.5707 0.2230 0.2997 5.8136 1.4516</span> -<span class="r-out co"><span class="r-pr">#></span> 62: 93.5431 -5.6373 -2.0371 -4.3384 -0.9276 0.1997 8.5187 2.3895 0.8575 4.4378 0.2258 0.3041 5.5746 1.4572</span> -<span class="r-out co"><span class="r-pr">#></span> 63: 93.5009 -5.5634 -2.0224 -4.3560 -0.9339 0.2167 8.0927 2.2700 0.8462 4.4449 0.2266 0.3162 5.4922 1.5233</span> -<span class="r-out co"><span class="r-pr">#></span> 64: 93.7369 -5.6032 -2.0362 -4.2323 -0.9355 0.2159 9.6684 2.1949 0.8514 4.2227 0.2300 0.3318 5.7597 1.4866</span> -<span class="r-out co"><span class="r-pr">#></span> 65: 93.5021 -5.5769 -2.0311 -4.3204 -0.9375 0.1927 9.5537 2.0852 0.8559 4.6151 0.2208 0.3550 5.6975 1.5031</span> -<span class="r-out co"><span class="r-pr">#></span> 66: 93.4211 -5.7184 -2.0384 -4.3041 -0.9228 0.2121 9.0760 2.6390 0.8430 4.3843 0.2098 0.3755 5.8990 1.5133</span> -<span class="r-out co"><span class="r-pr">#></span> 67: 93.3435 -5.6579 -2.0456 -4.2222 -0.9183 0.1825 8.6222 2.5071 0.8719 4.1651 0.2152 0.3567 5.9004 1.4874</span> -<span class="r-out co"><span class="r-pr">#></span> 68: 93.3914 -5.6554 -2.0420 -4.1618 -0.9303 0.1714 8.1911 2.3817 0.8856 3.9569 0.2272 0.3388 6.1793 1.4917</span> -<span class="r-out co"><span class="r-pr">#></span> 69: 93.5112 -5.6834 -2.0349 -4.1591 -0.9331 0.1759 8.9900 2.5191 0.9184 3.7590 0.2236 0.3219 6.1618 1.4697</span> -<span class="r-out co"><span class="r-pr">#></span> 70: 93.4289 -5.6576 -2.0273 -4.1763 -0.9399 0.1738 8.5405 2.4302 0.8725 3.5711 0.2149 0.3288 6.5324 1.5410</span> -<span class="r-out co"><span class="r-pr">#></span> 71: 93.2936 -5.6699 -2.0256 -4.1405 -0.9370 0.1922 8.1134 2.3831 0.8289 3.3925 0.2080 0.3548 5.9794 1.5904</span> -<span class="r-out co"><span class="r-pr">#></span> 72: 92.9152 -5.6742 -2.0382 -4.1523 -0.9411 0.1991 7.7078 2.4322 0.7875 3.2916 0.2007 0.3456 6.0999 1.6022</span> -<span class="r-out co"><span class="r-pr">#></span> 73: 92.8129 -5.8099 -2.0372 -4.1735 -0.9377 0.1605 8.2752 2.8931 0.7737 3.4015 0.2057 0.3283 6.0140 1.5472</span> -<span class="r-out co"><span class="r-pr">#></span> 74: 92.7806 -5.7269 -2.0315 -4.1877 -0.9399 0.1675 8.4688 2.7484 0.7773 3.4620 0.2174 0.3249 5.8495 1.5779</span> -<span class="r-out co"><span class="r-pr">#></span> 75: 92.9128 -5.8680 -2.0304 -4.1459 -0.9387 0.1567 8.0454 3.2365 0.7681 3.2935 0.2198 0.3187 5.8539 1.5815</span> -<span class="r-out co"><span class="r-pr">#></span> 76: 92.8931 -5.8483 -2.0253 -4.1815 -0.9387 0.1540 9.6800 3.0747 0.8007 3.5838 0.2198 0.3291 5.9005 1.5053</span> -<span class="r-out co"><span class="r-pr">#></span> 77: 92.7474 -5.7995 -2.0202 -4.1904 -0.9333 0.1724 10.0488 2.9210 0.7841 3.7255 0.2148 0.3465 5.9418 1.5569</span> -<span class="r-out co"><span class="r-pr">#></span> 78: 92.8150 -5.9608 -2.0025 -4.1583 -0.9511 0.1566 9.5464 3.5249 0.7858 3.6988 0.2246 0.3292 5.7737 1.5904</span> -<span class="r-out co"><span class="r-pr">#></span> 79: 92.6663 -6.0485 -2.0245 -4.1437 -0.9446 0.1786 9.0690 4.1252 0.7803 3.6526 0.2155 0.3335 5.9109 1.5521</span> -<span class="r-out co"><span class="r-pr">#></span> 80: 92.5932 -6.1001 -2.0304 -4.1969 -0.9409 0.1424 8.6156 4.6478 0.8007 4.0379 0.2114 0.3168 6.1732 1.5544</span> -<span class="r-out co"><span class="r-pr">#></span> 81: 92.6789 -6.3510 -2.0062 -4.2272 -0.9541 0.1360 8.3363 5.9861 0.7719 3.8800 0.2202 0.3010 5.6841 1.6317</span> -<span class="r-out co"><span class="r-pr">#></span> 82: 92.9996 -6.5680 -2.0048 -4.1609 -0.9578 0.1367 10.6901 7.4391 0.7962 3.6860 0.2092 0.2859 5.7335 1.6391</span> -<span class="r-out co"><span class="r-pr">#></span> 83: 93.1087 -6.5298 -1.9757 -4.1694 -0.9596 0.1323 10.5524 7.4660 0.8237 3.8009 0.2134 0.2716 5.9664 1.6316</span> -<span class="r-out co"><span class="r-pr">#></span> 84: 93.1929 -6.5844 -2.0191 -4.2021 -0.9616 0.1384 10.0248 7.7313 0.8230 3.6109 0.2110 0.2580 5.7854 1.5609</span> -<span class="r-out co"><span class="r-pr">#></span> 85: 92.9161 -6.4934 -2.0281 -4.2008 -0.9600 0.1107 9.5236 7.4269 0.8448 3.5630 0.2110 0.2451 5.6111 1.5333</span> -<span class="r-out co"><span class="r-pr">#></span> 86: 92.9816 -6.5397 -2.0234 -4.1830 -0.9694 0.1111 9.1945 7.4382 0.8481 3.3849 0.2166 0.2329 5.8375 1.5263</span> -<span class="r-out co"><span class="r-pr">#></span> 87: 93.0930 -6.5749 -2.0168 -4.1986 -0.9816 0.0926 8.7348 8.4431 0.8646 3.3032 0.2155 0.2212 5.7542 1.5736</span> -<span class="r-out co"><span class="r-pr">#></span> 88: 93.0765 -6.4914 -2.0274 -4.2274 -0.9870 0.1148 8.4666 8.0209 0.8666 3.5292 0.2048 0.2102 5.8988 1.5329</span> -<span class="r-out co"><span class="r-pr">#></span> 89: 92.8699 -6.6431 -2.0199 -4.2175 -0.9463 0.1011 8.4648 7.7973 0.8908 3.3980 0.1945 0.2102 5.6876 1.5177</span> -<span class="r-out co"><span class="r-pr">#></span> 90: 92.8225 -6.6932 -2.0211 -4.2175 -0.9505 0.0887 10.1862 8.7787 0.8730 3.3980 0.1877 0.1997 5.9135 1.4821</span> -<span class="r-out co"><span class="r-pr">#></span> 91: 92.7874 -6.7007 -2.0420 -4.2936 -0.9468 0.0927 11.2275 8.3397 0.8600 3.9490 0.1885 0.2147 6.1108 1.4315</span> -<span class="r-out co"><span class="r-pr">#></span> 92: 93.2320 -6.8088 -2.0341 -4.2817 -0.9582 0.1270 12.4029 9.6204 0.8503 3.7516 0.1950 0.2070 5.9434 1.5251</span> -<span class="r-out co"><span class="r-pr">#></span> 93: 93.8996 -6.5471 -2.0440 -4.2123 -0.9543 0.1140 11.7828 9.1394 0.8493 3.5640 0.1988 0.2017 6.1302 1.5568</span> -<span class="r-out co"><span class="r-pr">#></span> 94: 93.4416 -6.4623 -2.0448 -4.2188 -0.9595 0.1174 12.1277 8.6824 0.8568 3.3858 0.1975 0.1938 5.9173 1.5204</span> -<span class="r-out co"><span class="r-pr">#></span> 95: 93.2953 -6.1521 -2.0477 -4.2216 -0.9551 0.1152 11.5213 8.2483 0.8356 3.2165 0.1979 0.1855 5.8298 1.5357</span> -<span class="r-out co"><span class="r-pr">#></span> 96: 92.9577 -6.0477 -2.0579 -4.2534 -0.9465 0.1284 10.9452 7.8359 0.8202 3.3357 0.1937 0.1917 5.8590 1.5738</span> -<span class="r-out co"><span class="r-pr">#></span> 97: 92.8703 -6.1037 -2.0745 -4.1960 -0.9405 0.1417 10.4858 7.4441 0.8488 3.1690 0.1969 0.2016 5.7948 1.4759</span> -<span class="r-out co"><span class="r-pr">#></span> 98: 92.9728 -6.3534 -2.0868 -4.2155 -0.9444 0.1069 9.9615 7.1788 0.8736 3.1913 0.1998 0.2114 5.6533 1.4322</span> -<span class="r-out co"><span class="r-pr">#></span> 99: 93.4116 -6.1712 -2.0837 -4.2280 -0.9473 0.1197 9.4634 6.8198 0.8959 3.1806 0.1899 0.2167 5.9149 1.3768</span> -<span class="r-out co"><span class="r-pr">#></span> 100: 93.2598 -6.1345 -2.0645 -4.2237 -0.9575 0.1099 8.9903 6.4788 0.9204 3.2429 0.1903 0.2058 5.7085 1.4133</span> -<span class="r-out co"><span class="r-pr">#></span> 101: 93.3082 -6.1574 -2.0474 -4.2315 -0.9619 0.1161 9.0819 6.1549 0.8744 3.2049 0.1891 0.2278 5.6493 1.4894</span> -<span class="r-out co"><span class="r-pr">#></span> 102: 93.5741 -6.2923 -2.0484 -4.2853 -0.9665 0.1325 10.4108 5.8522 0.8804 3.5370 0.2024 0.2324 5.6995 1.4594</span> -<span class="r-out co"><span class="r-pr">#></span> 103: 92.9199 -6.1797 -2.0522 -4.2940 -0.9568 0.1289 9.8903 5.5596 0.8722 3.6682 0.1975 0.2398 5.5536 1.4510</span> -<span class="r-out co"><span class="r-pr">#></span> 104: 93.1139 -6.1630 -2.0546 -4.2912 -0.9613 0.1115 9.3958 5.2816 0.8648 3.6673 0.2010 0.2278 5.5768 1.4812</span> -<span class="r-out co"><span class="r-pr">#></span> 105: 93.4085 -6.0359 -2.0450 -4.2889 -0.9591 0.1258 8.9260 5.0175 0.8412 3.7286 0.1917 0.2171 5.6780 1.5203</span> -<span class="r-out co"><span class="r-pr">#></span> 106: 93.3103 -6.1029 -2.0425 -4.2948 -0.9579 0.0934 8.4797 4.7667 0.8539 3.6947 0.1947 0.2234 5.7210 1.4760</span> -<span class="r-out co"><span class="r-pr">#></span> 107: 93.6389 -5.9750 -2.0309 -4.2630 -0.9660 0.1110 8.0557 4.5283 0.8470 3.5100 0.2044 0.2299 5.6280 1.5525</span> -<span class="r-out co"><span class="r-pr">#></span> 108: 93.8641 -5.8551 -2.0360 -4.2311 -0.9629 0.0900 7.6529 4.3019 0.8567 3.3345 0.2014 0.2302 5.7841 1.5978</span> -<span class="r-out co"><span class="r-pr">#></span> 109: 93.6274 -6.0268 -2.0445 -4.3047 -0.9488 0.0979 7.2703 4.7807 0.8565 3.7665 0.1929 0.2271 5.7941 1.5580</span> -<span class="r-out co"><span class="r-pr">#></span> 110: 93.6320 -5.8321 -2.0413 -4.2855 -0.9477 0.1143 6.9068 4.5417 0.8412 3.6165 0.1901 0.2199 5.8169 1.5477</span> -<span class="r-out co"><span class="r-pr">#></span> 111: 93.6245 -5.8256 -2.0157 -4.2797 -0.9612 0.0940 6.5774 4.3146 0.8460 3.5782 0.1837 0.2182 5.6157 1.6424</span> -<span class="r-out co"><span class="r-pr">#></span> 112: 93.8512 -5.9045 -2.0116 -4.2409 -0.9708 0.0883 6.2486 4.0989 0.8658 3.5059 0.1761 0.2073 5.8852 1.6073</span> -<span class="r-out co"><span class="r-pr">#></span> 113: 93.7080 -5.9935 -2.0306 -4.1884 -0.9690 0.0740 5.9361 4.0088 0.9072 3.3400 0.1957 0.2169 6.3792 1.4770</span> -<span class="r-out co"><span class="r-pr">#></span> 114: 93.8574 -5.9185 -2.0233 -4.2030 -0.9588 0.1137 5.6393 3.8084 0.9322 3.2878 0.1939 0.2098 5.8891 1.5325</span> -<span class="r-out co"><span class="r-pr">#></span> 115: 93.7414 -5.8789 -2.0183 -4.2256 -0.9701 0.1105 5.6148 3.6180 0.9222 3.5507 0.1921 0.1993 5.6441 1.5458</span> -<span class="r-out co"><span class="r-pr">#></span> 116: 93.4104 -5.9704 -2.0428 -4.2091 -0.9807 0.1099 5.3341 4.1157 0.9363 3.4004 0.1968 0.2134 5.7764 1.4617</span> -<span class="r-out co"><span class="r-pr">#></span> 117: 93.5239 -5.9057 -2.0518 -4.2494 -0.9812 0.1127 6.8839 3.9099 0.9151 3.6604 0.1921 0.2095 5.4753 1.4249</span> -<span class="r-out co"><span class="r-pr">#></span> 118: 93.7599 -5.9418 -2.0482 -4.2272 -0.9822 0.1094 6.8133 3.7144 0.9198 3.5160 0.1971 0.2039 5.6467 1.4116</span> -<span class="r-out co"><span class="r-pr">#></span> 119: 93.6617 -6.0020 -2.0483 -4.2146 -0.9816 0.1003 6.4727 3.8251 0.9103 3.4716 0.1950 0.2109 5.8513 1.4268</span> -<span class="r-out co"><span class="r-pr">#></span> 120: 93.5436 -5.9804 -2.0458 -4.1906 -0.9819 0.1065 6.1490 3.6756 0.9088 3.2980 0.1989 0.2123 5.8268 1.4689</span> -<span class="r-out co"><span class="r-pr">#></span> 121: 93.4880 -5.9047 -2.0452 -4.1957 -0.9640 0.1349 5.8416 3.4918 0.8824 3.2437 0.1889 0.2017 5.7152 1.4382</span> -<span class="r-out co"><span class="r-pr">#></span> 122: 93.7406 -5.9844 -2.0596 -4.2328 -0.9558 0.1563 5.5495 3.7606 0.8489 3.3043 0.1795 0.2015 5.5095 1.5112</span> -<span class="r-out co"><span class="r-pr">#></span> 123: 93.6728 -6.0394 -2.0372 -4.2812 -0.9592 0.1507 5.2720 4.2004 0.8341 3.5274 0.1817 0.2008 5.6936 1.6011</span> -<span class="r-out co"><span class="r-pr">#></span> 124: 93.9591 -6.0483 -2.0280 -4.2613 -0.9594 0.1463 5.3846 4.1913 0.8351 3.4341 0.1870 0.2193 5.5694 1.5684</span> -<span class="r-out co"><span class="r-pr">#></span> 125: 94.0201 -5.9102 -2.0507 -4.2686 -0.9697 0.1455 5.1154 3.9818 0.8512 3.3475 0.1859 0.2165 5.6224 1.5643</span> -<span class="r-out co"><span class="r-pr">#></span> 126: 93.8825 -5.8970 -2.0543 -4.2569 -0.9663 0.1493 4.9144 3.7827 0.8907 3.3030 0.1876 0.2180 5.7351 1.4722</span> -<span class="r-out co"><span class="r-pr">#></span> 127: 93.9893 -5.8955 -2.0624 -4.2430 -0.9802 0.1476 7.2413 3.5935 0.8915 3.2740 0.1851 0.2110 5.7614 1.4305</span> -<span class="r-out co"><span class="r-pr">#></span> 128: 94.1849 -5.9123 -2.0624 -4.2385 -0.9786 0.1523 7.9575 3.4139 0.9094 3.2656 0.1807 0.2198 5.7366 1.4264</span> -<span class="r-out co"><span class="r-pr">#></span> 129: 94.0812 -6.0044 -2.0696 -4.3056 -0.9770 0.1693 8.7809 3.7526 0.9111 3.6172 0.1859 0.2255 5.8064 1.4718</span> -<span class="r-out co"><span class="r-pr">#></span> 130: 93.6046 -6.1387 -2.0718 -4.3056 -0.9821 0.1477 8.3419 4.3029 0.9177 3.6172 0.1867 0.2143 5.8893 1.4447</span> -<span class="r-out co"><span class="r-pr">#></span> 131: 93.5216 -6.1347 -2.0740 -4.3114 -0.9766 0.1288 8.2937 4.3407 0.9250 3.5298 0.1881 0.2293 5.8054 1.4219</span> -<span class="r-out co"><span class="r-pr">#></span> 132: 93.6142 -6.2789 -2.0786 -4.3297 -0.9716 0.1288 8.3731 5.1225 0.9236 3.6683 0.1929 0.2295 5.8064 1.4194</span> -<span class="r-out co"><span class="r-pr">#></span> 133: 93.4410 -5.9177 -2.0916 -4.3557 -0.9798 0.1066 7.9544 4.8663 0.9537 3.7076 0.1937 0.2279 5.9844 1.4297</span> -<span class="r-out co"><span class="r-pr">#></span> 134: 93.4716 -5.9152 -2.0838 -4.3611 -0.9818 0.1332 7.5567 4.6230 0.9161 3.7833 0.2017 0.2308 6.0611 1.5717</span> -<span class="r-out co"><span class="r-pr">#></span> 135: 93.3787 -6.0381 -2.0728 -4.2627 -0.9719 0.1051 7.2396 4.3919 0.8970 3.5941 0.1916 0.2193 5.8837 1.6057</span> -<span class="r-out co"><span class="r-pr">#></span> 136: 93.4339 -5.9876 -2.0801 -4.3002 -0.9690 0.1214 6.8776 4.1723 0.8888 3.4144 0.2002 0.2227 6.0141 1.5231</span> -<span class="r-out co"><span class="r-pr">#></span> 137: 93.7639 -6.0411 -2.0803 -4.2799 -0.9646 0.1484 6.5337 3.9765 0.8969 3.2437 0.1995 0.2115 5.9404 1.6402</span> -<span class="r-out co"><span class="r-pr">#></span> 138: 93.6414 -6.0122 -2.0714 -4.2666 -0.9755 0.1506 7.4057 3.7962 0.9242 3.1524 0.1934 0.2010 6.0666 1.5001</span> -<span class="r-out co"><span class="r-pr">#></span> 139: 93.7743 -5.7966 -2.0613 -4.2289 -0.9722 0.1383 7.9358 3.6064 0.9015 2.9948 0.1946 0.2029 5.9655 1.5250</span> -<span class="r-out co"><span class="r-pr">#></span> 140: 93.1082 -5.7994 -2.0388 -4.2289 -0.9659 0.1382 8.0282 3.4261 0.9053 2.9079 0.1909 0.2138 5.9183 1.5191</span> -<span class="r-out co"><span class="r-pr">#></span> 141: 93.2122 -6.0181 -2.0396 -4.2398 -0.9587 0.1016 8.9769 3.9426 0.9028 2.9136 0.1941 0.2195 6.1560 1.4902</span> -<span class="r-out co"><span class="r-pr">#></span> 142: 93.4684 -6.1438 -2.0273 -4.2541 -0.9508 0.0848 8.5281 4.8727 0.9056 2.9875 0.1901 0.2233 6.2546 1.4695</span> -<span class="r-out co"><span class="r-pr">#></span> 143: 93.0059 -6.0964 -2.0145 -4.2760 -0.9563 0.0826 8.1017 4.6291 0.9312 3.1063 0.1850 0.2138 6.5768 1.4391</span> -<span class="r-out co"><span class="r-pr">#></span> 144: 93.0612 -6.1127 -1.9951 -4.2589 -0.9539 0.0904 7.6966 4.6160 0.9623 3.1681 0.1824 0.2032 6.1506 1.4497</span> -<span class="r-out co"><span class="r-pr">#></span> 145: 93.5170 -6.1066 -1.9951 -4.3574 -0.9478 0.1040 7.3118 4.6263 0.9639 3.6914 0.1986 0.2292 5.9389 1.4867</span> -<span class="r-out co"><span class="r-pr">#></span> 146: 93.4915 -6.3235 -2.0006 -4.3866 -0.9579 0.1202 6.9462 6.0529 0.9514 3.9899 0.1887 0.2335 5.9265 1.4978</span> -<span class="r-out co"><span class="r-pr">#></span> 147: 93.8963 -6.1119 -2.0055 -4.3446 -0.9682 0.1242 7.1711 5.7503 0.9315 3.7904 0.1923 0.2332 5.9346 1.5021</span> -<span class="r-out co"><span class="r-pr">#></span> 148: 93.6758 -5.9705 -2.0137 -4.2906 -0.9614 0.1125 6.8125 5.4628 0.9506 3.6009 0.1913 0.2371 6.2579 1.4384</span> -<span class="r-out co"><span class="r-pr">#></span> 149: 93.6499 -6.0049 -2.0246 -4.2730 -0.9776 0.0996 6.4719 5.1896 0.9736 3.4209 0.1817 0.2252 6.3224 1.3878</span> -<span class="r-out co"><span class="r-pr">#></span> 150: 94.0242 -5.9760 -2.0176 -4.2182 -0.9773 0.1032 6.1483 4.9301 0.9944 3.2498 0.1807 0.2290 6.5662 1.3618</span> -<span class="r-out co"><span class="r-pr">#></span> 151: 93.9234 -5.8772 -2.0132 -4.2362 -0.9651 0.1058 7.2453 4.6836 0.9824 3.4860 0.1806 0.2175 6.2575 1.4370</span> -<span class="r-out co"><span class="r-pr">#></span> 152: 94.2513 -5.9391 -2.0814 -4.2278 -0.9753 0.1221 4.9753 3.4013 0.9808 3.3265 0.1836 0.1897 6.6966 1.3457</span> -<span class="r-out co"><span class="r-pr">#></span> 153: 93.9434 -6.1294 -2.0570 -4.2447 -0.9761 0.1527 5.0454 4.3115 0.9494 3.3663 0.1684 0.1680 5.9106 1.4777</span> -<span class="r-out co"><span class="r-pr">#></span> 154: 93.8141 -6.2749 -2.0366 -4.2383 -0.9835 0.1440 5.5466 5.3351 0.9320 3.3337 0.1731 0.1913 5.8842 1.4325</span> -<span class="r-out co"><span class="r-pr">#></span> 155: 94.1987 -6.1029 -2.0252 -4.2520 -0.9780 0.1132 7.1508 4.2713 0.9457 3.3428 0.1727 0.1691 6.1632 1.4658</span> -<span class="r-out co"><span class="r-pr">#></span> 156: 94.0626 -6.2640 -2.0263 -4.2461 -0.9854 0.1346 5.6296 5.1645 0.9423 3.3987 0.1697 0.1778 5.9631 1.4483</span> -<span class="r-out co"><span class="r-pr">#></span> 157: 93.9319 -6.1392 -2.0388 -4.2294 -0.9921 0.1265 5.6768 4.7366 0.9210 3.3673 0.1733 0.1789 5.9114 1.4976</span> -<span class="r-out co"><span class="r-pr">#></span> 158: 93.9123 -6.1970 -2.0165 -4.2241 -0.9924 0.1540 7.2552 4.7537 0.9369 3.2727 0.1805 0.1923 5.9324 1.5351</span> -<span class="r-out co"><span class="r-pr">#></span> 159: 93.9704 -6.4018 -2.0455 -4.2127 -0.9919 0.1413 7.7561 6.0732 0.9802 3.3376 0.1806 0.2260 6.4511 1.4227</span> -<span class="r-out co"><span class="r-pr">#></span> 160: 94.1967 -6.2985 -2.0412 -4.2264 -0.9795 0.1206 8.3836 6.1319 0.9689 3.4685 0.1792 0.2150 6.5116 1.4706</span> -<span class="r-out co"><span class="r-pr">#></span> 161: 94.3500 -6.1427 -2.0189 -4.2242 -1.0022 0.0837 8.0282 4.5505 0.9524 3.3269 0.1859 0.1816 6.0642 1.4746</span> -<span class="r-out co"><span class="r-pr">#></span> 162: 94.2711 -5.9578 -2.0215 -4.2078 -1.0110 0.0946 7.8634 3.3072 0.9559 3.2374 0.1876 0.1791 6.0798 1.4903</span> -<span class="r-out co"><span class="r-pr">#></span> 163: 93.9824 -5.8794 -2.0409 -4.2367 -0.9970 0.1150 9.3872 3.0498 0.9830 3.3179 0.1880 0.1828 5.8091 1.4852</span> -<span class="r-out co"><span class="r-pr">#></span> 164: 94.2013 -5.8651 -2.0122 -4.2257 -0.9906 0.1267 7.1953 3.0510 0.9697 3.2713 0.1871 0.1832 5.8741 1.5313</span> -<span class="r-out co"><span class="r-pr">#></span> 165: 94.1804 -5.7868 -2.0200 -4.2053 -0.9812 0.1219 6.7375 2.4769 0.9688 3.2706 0.1910 0.1859 5.7890 1.5188</span> -<span class="r-out co"><span class="r-pr">#></span> 166: 93.9790 -5.8156 -2.0311 -4.2438 -0.9784 0.1247 5.7617 2.6907 0.9533 3.5342 0.1953 0.1872 5.8816 1.5243</span> -<span class="r-out co"><span class="r-pr">#></span> 167: 93.2524 -5.8603 -2.0497 -4.2594 -0.9787 0.1265 4.7086 2.9121 0.9117 3.4696 0.1943 0.1832 5.9672 1.4567</span> -<span class="r-out co"><span class="r-pr">#></span> 168: 93.2924 -6.0371 -2.0528 -4.2607 -0.9727 0.1201 5.5273 4.0286 0.9177 3.4501 0.1918 0.1908 5.7790 1.4701</span> -<span class="r-out co"><span class="r-pr">#></span> 169: 93.4838 -6.1497 -2.0389 -4.2716 -0.9639 0.1127 5.4524 4.2700 0.9544 3.4329 0.1940 0.1871 5.7795 1.4575</span> -<span class="r-out co"><span class="r-pr">#></span> 170: 93.3951 -6.2298 -2.0438 -4.4133 -0.9939 0.1088 6.1460 4.6552 0.9645 4.5240 0.1978 0.2091 5.7549 1.5233</span> -<span class="r-out co"><span class="r-pr">#></span> 171: 93.4113 -6.1187 -2.0536 -4.4019 -0.9771 0.0899 6.8123 4.0073 0.9531 4.4290 0.1878 0.1970 5.9067 1.4857</span> -<span class="r-out co"><span class="r-pr">#></span> 172: 93.1140 -5.9515 -2.0530 -4.3250 -0.9723 0.1094 5.1247 3.4502 0.9572 3.8504 0.1954 0.1944 5.8583 1.4867</span> -<span class="r-out co"><span class="r-pr">#></span> 173: 92.9782 -6.0415 -2.0633 -4.2887 -0.9608 0.1081 4.1020 3.8967 0.9478 3.7222 0.1890 0.1812 5.9473 1.4583</span> -<span class="r-out co"><span class="r-pr">#></span> 174: 92.9661 -5.9295 -2.0457 -4.2907 -0.9626 0.0991 5.7954 3.3581 0.9785 3.7311 0.1867 0.2026 5.8087 1.4797</span> -<span class="r-out co"><span class="r-pr">#></span> 175: 93.2577 -5.8895 -2.0281 -4.2845 -0.9560 0.0829 7.3434 3.1501 0.9975 3.6334 0.1920 0.2151 5.4717 1.4832</span> -<span class="r-out co"><span class="r-pr">#></span> 176: 93.1210 -5.9567 -2.0370 -4.2848 -0.9488 0.0787 6.8946 3.4999 0.9983 3.6159 0.1922 0.2233 5.8426 1.4096</span> -<span class="r-out co"><span class="r-pr">#></span> 177: 92.5456 -6.1797 -2.0319 -4.2684 -0.9401 0.0873 6.9744 5.2939 0.9928 3.4880 0.1989 0.2213 5.9613 1.4367</span> -<span class="r-out co"><span class="r-pr">#></span> 178: 92.6854 -6.1483 -2.0278 -4.2705 -0.9504 0.0630 5.0582 5.0622 0.9953 3.4915 0.1930 0.2238 5.9775 1.4263</span> -<span class="r-out co"><span class="r-pr">#></span> 179: 93.1323 -6.1739 -2.0353 -4.2590 -0.9455 0.0584 4.9914 4.7898 0.9817 3.4163 0.1899 0.2124 5.9579 1.4242</span> -<span class="r-out co"><span class="r-pr">#></span> 180: 93.0611 -6.2228 -2.0441 -4.2977 -0.9387 0.0320 4.0323 5.5685 0.9890 3.7202 0.1940 0.2335 6.2224 1.4194</span> -<span class="r-out co"><span class="r-pr">#></span> 181: 92.7741 -6.1462 -2.0477 -4.3335 -0.9454 0.1011 3.7007 5.1590 0.9807 3.8469 0.1939 0.2463 5.9703 1.4343</span> -<span class="r-out co"><span class="r-pr">#></span> 182: 93.0775 -6.0640 -2.0496 -4.3171 -0.9444 0.0897 5.0266 4.5597 0.9792 3.7741 0.1931 0.2186 5.6727 1.4858</span> -<span class="r-out co"><span class="r-pr">#></span> 183: 93.2566 -6.1757 -2.0368 -4.2888 -0.9560 0.0809 5.8284 5.2504 0.9636 3.7078 0.1939 0.2262 5.5170 1.4560</span> -<span class="r-out co"><span class="r-pr">#></span> 184: 93.0357 -6.1158 -2.0217 -4.3111 -0.9453 0.0901 6.7209 5.4048 0.9503 3.8949 0.1967 0.2209 5.3578 1.4704</span> -<span class="r-out co"><span class="r-pr">#></span> 185: 93.0173 -6.1998 -2.0371 -4.3713 -0.9451 0.0752 6.1040 5.8272 0.9333 4.4038 0.1951 0.2238 5.5896 1.4202</span> -<span class="r-out co"><span class="r-pr">#></span> 186: 93.2835 -6.1217 -2.0383 -4.3308 -0.9574 0.1110 6.0519 4.7669 0.9400 4.0265 0.1972 0.2274 5.4560 1.4602</span> -<span class="r-out co"><span class="r-pr">#></span> 187: 93.5312 -6.3356 -2.0253 -4.3418 -0.9583 0.1166 6.7561 5.8784 0.9346 4.0264 0.2038 0.2281 5.5024 1.4994</span> -<span class="r-out co"><span class="r-pr">#></span> 188: 93.6460 -5.8426 -2.0237 -4.4519 -0.9594 0.1283 6.3492 3.4189 0.9091 4.9358 0.2086 0.2348 5.4301 1.5893</span> -<span class="r-out co"><span class="r-pr">#></span> 189: 93.8538 -6.0183 -2.0178 -4.3911 -0.9797 0.1262 8.7939 3.7358 0.9008 4.4894 0.2125 0.2199 5.6613 1.5073</span> -<span class="r-out co"><span class="r-pr">#></span> 190: 93.1543 -6.1364 -2.0451 -4.4389 -0.9708 0.1584 9.9803 4.2747 0.8922 4.8507 0.2084 0.2607 5.9136 1.4572</span> -<span class="r-out co"><span class="r-pr">#></span> 191: 93.4334 -6.1466 -2.0389 -4.4661 -0.9678 0.1565 7.8390 4.4393 0.9022 4.7857 0.2105 0.2634 5.7161 1.5325</span> -<span class="r-out co"><span class="r-pr">#></span> 192: 93.3623 -6.0940 -2.0240 -4.4569 -0.9673 0.1420 8.0856 4.3185 0.8895 4.4721 0.2113 0.2350 5.5282 1.5221</span> -<span class="r-out co"><span class="r-pr">#></span> 193: 93.1990 -5.9864 -2.0301 -4.4538 -0.9563 0.1515 8.4425 3.7598 0.8814 4.4376 0.2013 0.2257 5.4205 1.4820</span> -<span class="r-out co"><span class="r-pr">#></span> 194: 93.3165 -6.0045 -2.0353 -4.4314 -0.9525 0.1486 8.2370 3.6742 0.8947 4.4594 0.1960 0.2248 5.4579 1.4767</span> -<span class="r-out co"><span class="r-pr">#></span> 195: 93.1288 -6.1006 -2.0551 -4.5184 -0.9503 0.1583 9.6259 4.2294 0.9040 5.1981 0.1950 0.1962 5.5602 1.4254</span> -<span class="r-out co"><span class="r-pr">#></span> 196: 93.1943 -5.9871 -2.0607 -4.4728 -0.9446 0.1482 9.3401 3.5579 0.8925 4.7901 0.1892 0.1879 5.7296 1.4172</span> -<span class="r-out co"><span class="r-pr">#></span> 197: 93.5803 -5.9131 -2.0522 -4.3675 -0.9476 0.1571 7.2599 3.4241 0.8857 3.8551 0.1886 0.1793 5.4832 1.6006</span> -<span class="r-out co"><span class="r-pr">#></span> 198: 93.5703 -5.9980 -2.0550 -4.3578 -0.9519 0.1491 7.0416 3.8805 0.8563 3.7930 0.1882 0.1896 5.4355 1.5402</span> -<span class="r-out co"><span class="r-pr">#></span> 199: 93.2909 -5.8288 -2.0532 -4.3605 -0.9518 0.1692 8.3926 3.0173 0.8566 3.8610 0.1902 0.2033 5.5735 1.5647</span> -<span class="r-out co"><span class="r-pr">#></span> 200: 93.4049 -5.7474 -2.0447 -4.3548 -0.9517 0.1812 7.4977 2.8256 0.8520 3.8236 0.1897 0.2060 5.5092 1.5699</span> -<span class="r-out co"><span class="r-pr">#></span> 201: 93.3386 -5.8209 -2.0398 -4.4174 -0.9597 0.1738 6.3555 3.0871 0.8431 4.3211 0.1853 0.2062 5.5460 1.5925</span> -<span class="r-out co"><span class="r-pr">#></span> 202: 93.3397 -5.8313 -2.0387 -4.4364 -0.9580 0.1669 6.0946 3.1018 0.8460 4.5093 0.1821 0.2068 5.6622 1.5740</span> -<span class="r-out co"><span class="r-pr">#></span> 203: 93.3071 -5.8276 -2.0384 -4.4758 -0.9571 0.1639 5.7815 3.0575 0.8608 4.9441 0.1826 0.2052 5.6855 1.5570</span> -<span class="r-out co"><span class="r-pr">#></span> 204: 93.3138 -5.8477 -2.0368 -4.4714 -0.9541 0.1658 5.7526 3.1322 0.8704 4.9129 0.1816 0.2057 5.6642 1.5606</span> -<span class="r-out co"><span class="r-pr">#></span> 205: 93.3066 -5.8537 -2.0395 -4.4842 -0.9521 0.1642 5.6045 3.1633 0.8748 5.0053 0.1805 0.2036 5.6633 1.5550</span> -<span class="r-out co"><span class="r-pr">#></span> 206: 93.3042 -5.8790 -2.0453 -4.4977 -0.9501 0.1633 5.7219 3.3320 0.8807 5.1121 0.1793 0.1999 5.6888 1.5413</span> -<span class="r-out co"><span class="r-pr">#></span> 207: 93.3281 -5.9005 -2.0504 -4.5109 -0.9480 0.1629 5.8004 3.4696 0.8865 5.2248 0.1789 0.1961 5.7206 1.5357</span> -<span class="r-out co"><span class="r-pr">#></span> 208: 93.3437 -5.8972 -2.0569 -4.5200 -0.9452 0.1641 5.7523 3.4604 0.8875 5.2848 0.1787 0.1933 5.7450 1.5288</span> -<span class="r-out co"><span class="r-pr">#></span> 209: 93.3265 -5.8864 -2.0628 -4.5092 -0.9440 0.1639 5.5355 3.4138 0.8882 5.1586 0.1791 0.1916 5.7744 1.5283</span> -<span class="r-out co"><span class="r-pr">#></span> 210: 93.3087 -5.8812 -2.0671 -4.5004 -0.9426 0.1677 5.3488 3.3975 0.8895 5.0589 0.1798 0.1924 5.7781 1.5307</span> -<span class="r-out co"><span class="r-pr">#></span> 211: 93.2807 -5.8760 -2.0703 -4.5009 -0.9413 0.1709 5.2654 3.3770 0.8894 5.0377 0.1805 0.1927 5.7808 1.5282</span> -<span class="r-out co"><span class="r-pr">#></span> 212: 93.2815 -5.8637 -2.0711 -4.4955 -0.9409 0.1708 5.3028 3.3250 0.8914 4.9702 0.1819 0.1941 5.7827 1.5274</span> -<span class="r-out co"><span class="r-pr">#></span> 213: 93.2828 -5.8481 -2.0709 -4.4895 -0.9396 0.1702 5.3840 3.2614 0.8913 4.9108 0.1826 0.1953 5.7744 1.5301</span> -<span class="r-out co"><span class="r-pr">#></span> 214: 93.2645 -5.8422 -2.0704 -4.4882 -0.9384 0.1710 5.3939 3.2358 0.8931 4.8944 0.1828 0.1955 5.7797 1.5351</span> -<span class="r-out co"><span class="r-pr">#></span> 215: 93.2591 -5.8519 -2.0709 -4.4858 -0.9380 0.1713 5.5142 3.2959 0.8953 4.8587 0.1822 0.1960 5.7853 1.5369</span> -<span class="r-out co"><span class="r-pr">#></span> 216: 93.2595 -5.8523 -2.0715 -4.4827 -0.9376 0.1723 5.5563 3.3077 0.8964 4.8306 0.1817 0.1973 5.7975 1.5396</span> -<span class="r-out co"><span class="r-pr">#></span> 217: 93.2503 -5.8512 -2.0732 -4.4737 -0.9373 0.1734 5.5036 3.3182 0.8959 4.7582 0.1817 0.1992 5.7940 1.5365</span> -<span class="r-out co"><span class="r-pr">#></span> 218: 93.2345 -5.8463 -2.0749 -4.4639 -0.9372 0.1747 5.5046 3.2959 0.8959 4.6771 0.1817 0.2008 5.7889 1.5340</span> -<span class="r-out co"><span class="r-pr">#></span> 219: 93.2264 -5.8439 -2.0757 -4.4549 -0.9364 0.1759 5.4970 3.2802 0.8966 4.6015 0.1819 0.2027 5.7804 1.5321</span> -<span class="r-out co"><span class="r-pr">#></span> 220: 93.2259 -5.8464 -2.0758 -4.4493 -0.9363 0.1771 5.4793 3.2944 0.8950 4.5498 0.1823 0.2049 5.7745 1.5344</span> -<span class="r-out co"><span class="r-pr">#></span> 221: 93.2243 -5.8505 -2.0768 -4.4443 -0.9367 0.1785 5.5360 3.3132 0.8924 4.5028 0.1829 0.2068 5.7556 1.5329</span> -<span class="r-out co"><span class="r-pr">#></span> 222: 93.2385 -5.8603 -2.0776 -4.4371 -0.9376 0.1800 5.5401 3.3878 0.8903 4.4416 0.1834 0.2096 5.7522 1.5317</span> -<span class="r-out co"><span class="r-pr">#></span> 223: 93.2339 -5.8634 -2.0780 -4.4309 -0.9377 0.1803 5.5522 3.4132 0.8882 4.3844 0.1838 0.2118 5.7457 1.5323</span> -<span class="r-out co"><span class="r-pr">#></span> 224: 93.2379 -5.8686 -2.0778 -4.4262 -0.9374 0.1803 5.5469 3.4421 0.8848 4.3375 0.1842 0.2137 5.7429 1.5323</span> -<span class="r-out co"><span class="r-pr">#></span> 225: 93.2329 -5.8654 -2.0784 -4.4222 -0.9373 0.1811 5.5553 3.4255 0.8843 4.2952 0.1848 0.2160 5.7452 1.5295</span> -<span class="r-out co"><span class="r-pr">#></span> 226: 93.2330 -5.8621 -2.0789 -4.4182 -0.9366 0.1816 5.5838 3.4123 0.8838 4.2565 0.1858 0.2176 5.7453 1.5284</span> -<span class="r-out co"><span class="r-pr">#></span> 227: 93.2309 -5.8549 -2.0794 -4.4153 -0.9365 0.1823 5.6720 3.3787 0.8827 4.2227 0.1866 0.2181 5.7339 1.5287</span> -<span class="r-out co"><span class="r-pr">#></span> 228: 93.2248 -5.8556 -2.0794 -4.4116 -0.9372 0.1832 5.7344 3.3780 0.8830 4.1863 0.1873 0.2200 5.7232 1.5308</span> -<span class="r-out co"><span class="r-pr">#></span> 229: 93.2215 -5.8615 -2.0798 -4.4081 -0.9373 0.1844 5.8478 3.4087 0.8821 4.1558 0.1878 0.2217 5.7174 1.5283</span> -<span class="r-out co"><span class="r-pr">#></span> 230: 93.2122 -5.8646 -2.0807 -4.4053 -0.9372 0.1858 5.8987 3.4233 0.8800 4.1288 0.1881 0.2233 5.7073 1.5272</span> -<span class="r-out co"><span class="r-pr">#></span> 231: 93.2080 -5.8665 -2.0816 -4.4025 -0.9372 0.1872 5.9544 3.4381 0.8782 4.1008 0.1883 0.2250 5.7006 1.5283</span> -<span class="r-out co"><span class="r-pr">#></span> 232: 93.1921 -5.8677 -2.0829 -4.3997 -0.9370 0.1887 5.9768 3.4440 0.8770 4.0748 0.1883 0.2268 5.7012 1.5261</span> -<span class="r-out co"><span class="r-pr">#></span> 233: 93.1794 -5.8674 -2.0840 -4.3972 -0.9363 0.1892 6.0074 3.4397 0.8757 4.0495 0.1884 0.2281 5.6997 1.5235</span> -<span class="r-out co"><span class="r-pr">#></span> 234: 93.1623 -5.8677 -2.0853 -4.3959 -0.9358 0.1898 5.9759 3.4442 0.8750 4.0330 0.1887 0.2295 5.7000 1.5223</span> -<span class="r-out co"><span class="r-pr">#></span> 235: 93.1499 -5.8709 -2.0862 -4.3918 -0.9356 0.1900 5.9951 3.4709 0.8747 4.0020 0.1891 0.2309 5.7002 1.5219</span> -<span class="r-out co"><span class="r-pr">#></span> 236: 93.1408 -5.8764 -2.0875 -4.3879 -0.9349 0.1898 6.0359 3.5027 0.8752 3.9720 0.1895 0.2321 5.7098 1.5196</span> -<span class="r-out co"><span class="r-pr">#></span> 237: 93.1307 -5.8766 -2.0887 -4.3843 -0.9344 0.1896 6.0589 3.5108 0.8755 3.9437 0.1900 0.2330 5.7176 1.5174</span> -<span class="r-out co"><span class="r-pr">#></span> 238: 93.1233 -5.8767 -2.0889 -4.3806 -0.9341 0.1891 6.0959 3.5158 0.8745 3.9173 0.1907 0.2339 5.7198 1.5169</span> -<span class="r-out co"><span class="r-pr">#></span> 239: 93.1245 -5.8810 -2.0889 -4.3775 -0.9337 0.1885 6.1196 3.5614 0.8746 3.8935 0.1915 0.2349 5.7177 1.5172</span> -<span class="r-out co"><span class="r-pr">#></span> 240: 93.1180 -5.8836 -2.0893 -4.3745 -0.9332 0.1883 6.1647 3.6004 0.8741 3.8709 0.1921 0.2360 5.7150 1.5192</span> -<span class="r-out co"><span class="r-pr">#></span> 241: 93.1096 -5.8838 -2.0898 -4.3714 -0.9327 0.1883 6.2283 3.6196 0.8743 3.8487 0.1927 0.2366 5.7177 1.5202</span> -<span class="r-out co"><span class="r-pr">#></span> 242: 93.1058 -5.8804 -2.0912 -4.3684 -0.9320 0.1888 6.2553 3.6018 0.8723 3.8274 0.1933 0.2378 5.7265 1.5198</span> -<span class="r-out co"><span class="r-pr">#></span> 243: 93.0953 -5.8762 -2.0924 -4.3668 -0.9315 0.1892 6.2692 3.5785 0.8705 3.8130 0.1940 0.2391 5.7353 1.5205</span> -<span class="r-out co"><span class="r-pr">#></span> 244: 93.0840 -5.8758 -2.0928 -4.3658 -0.9310 0.1889 6.2702 3.5746 0.8695 3.8007 0.1947 0.2401 5.7382 1.5205</span> -<span class="r-out co"><span class="r-pr">#></span> 245: 93.0720 -5.8795 -2.0933 -4.3647 -0.9306 0.1895 6.3022 3.5971 0.8685 3.7886 0.1953 0.2407 5.7367 1.5192</span> -<span class="r-out co"><span class="r-pr">#></span> 246: 93.0626 -5.8798 -2.0933 -4.3637 -0.9301 0.1898 6.2987 3.5992 0.8680 3.7781 0.1957 0.2410 5.7331 1.5184</span> -<span class="r-out co"><span class="r-pr">#></span> 247: 93.0526 -5.8805 -2.0934 -4.3610 -0.9298 0.1903 6.3067 3.6060 0.8682 3.7618 0.1963 0.2414 5.7329 1.5189</span> -<span class="r-out co"><span class="r-pr">#></span> 248: 93.0481 -5.8780 -2.0933 -4.3583 -0.9296 0.1911 6.3135 3.6007 0.8683 3.7460 0.1967 0.2420 5.7344 1.5191</span> -<span class="r-out co"><span class="r-pr">#></span> 249: 93.0483 -5.8762 -2.0933 -4.3558 -0.9294 0.1913 6.3095 3.5961 0.8685 3.7298 0.1970 0.2422 5.7414 1.5179</span> -<span class="r-out co"><span class="r-pr">#></span> 250: 93.0520 -5.8768 -2.0931 -4.3538 -0.9292 0.1912 6.2900 3.6003 0.8692 3.7176 0.1973 0.2424 5.7547 1.5148</span> -<span class="r-out co"><span class="r-pr">#></span> 251: 93.0430 -5.8769 -2.0930 -4.3516 -0.9291 0.1905 6.2815 3.6041 0.8704 3.7045 0.1975 0.2427 5.7653 1.5123</span> -<span class="r-out co"><span class="r-pr">#></span> 252: 93.0300 -5.8743 -2.0928 -4.3490 -0.9291 0.1901 6.2896 3.5885 0.8716 3.6919 0.1978 0.2428 5.7797 1.5106</span> -<span class="r-out co"><span class="r-pr">#></span> 253: 93.0217 -5.8740 -2.0926 -4.3468 -0.9289 0.1898 6.3238 3.5875 0.8731 3.6817 0.1981 0.2429 5.7885 1.5102</span> -<span class="r-out co"><span class="r-pr">#></span> 254: 93.0147 -5.8729 -2.0924 -4.3439 -0.9289 0.1892 6.3418 3.5857 0.8732 3.6683 0.1980 0.2426 5.7912 1.5102</span> -<span class="r-out co"><span class="r-pr">#></span> 255: 93.0144 -5.8743 -2.0922 -4.3407 -0.9290 0.1885 6.3755 3.5933 0.8735 3.6580 0.1979 0.2420 5.7932 1.5086</span> -<span class="r-out co"><span class="r-pr">#></span> 256: 93.0136 -5.8778 -2.0919 -4.3376 -0.9290 0.1876 6.3932 3.6240 0.8741 3.6481 0.1980 0.2418 5.7969 1.5066</span> -<span class="r-out co"><span class="r-pr">#></span> 257: 93.0116 -5.8792 -2.0917 -4.3345 -0.9291 0.1862 6.4096 3.6459 0.8744 3.6385 0.1980 0.2414 5.7990 1.5065</span> -<span class="r-out co"><span class="r-pr">#></span> 258: 93.0084 -5.8812 -2.0913 -4.3319 -0.9290 0.1842 6.4231 3.6686 0.8753 3.6281 0.1980 0.2414 5.8024 1.5050</span> -<span class="r-out co"><span class="r-pr">#></span> 259: 93.0090 -5.8866 -2.0909 -4.3293 -0.9287 0.1825 6.4361 3.7063 0.8762 3.6181 0.1981 0.2413 5.8106 1.5030</span> -<span class="r-out co"><span class="r-pr">#></span> 260: 93.0067 -5.8911 -2.0902 -4.3265 -0.9283 0.1811 6.4128 3.7384 0.8765 3.6076 0.1981 0.2412 5.8102 1.5026</span> -<span class="r-out co"><span class="r-pr">#></span> 261: 93.0060 -5.8933 -2.0894 -4.3237 -0.9284 0.1799 6.4253 3.7604 0.8765 3.5968 0.1981 0.2410 5.8080 1.5026</span> -<span class="r-out co"><span class="r-pr">#></span> 262: 93.0051 -5.8934 -2.0884 -4.3208 -0.9285 0.1789 6.4008 3.7597 0.8762 3.5855 0.1981 0.2412 5.8046 1.5020</span> -<span class="r-out co"><span class="r-pr">#></span> 263: 93.0019 -5.8945 -2.0875 -4.3182 -0.9287 0.1781 6.3788 3.7644 0.8758 3.5756 0.1982 0.2411 5.8048 1.5023</span> -<span class="r-out co"><span class="r-pr">#></span> 264: 93.0021 -5.8959 -2.0870 -4.3158 -0.9293 0.1773 6.3614 3.7682 0.8749 3.5667 0.1983 0.2410 5.8017 1.5021</span> -<span class="r-out co"><span class="r-pr">#></span> 265: 93.0053 -5.8989 -2.0866 -4.3130 -0.9296 0.1766 6.3506 3.7814 0.8739 3.5567 0.1982 0.2409 5.7995 1.5018</span> -<span class="r-out co"><span class="r-pr">#></span> 266: 93.0061 -5.8992 -2.0864 -4.3104 -0.9300 0.1757 6.3307 3.7730 0.8733 3.5471 0.1982 0.2408 5.7994 1.5012</span> -<span class="r-out co"><span class="r-pr">#></span> 267: 93.0098 -5.9009 -2.0861 -4.3077 -0.9302 0.1749 6.3326 3.7738 0.8730 3.5388 0.1983 0.2407 5.7964 1.5004</span> -<span class="r-out co"><span class="r-pr">#></span> 268: 93.0144 -5.9000 -2.0853 -4.3054 -0.9304 0.1740 6.3487 3.7623 0.8729 3.5290 0.1985 0.2405 5.7897 1.5014</span> -<span class="r-out co"><span class="r-pr">#></span> 269: 93.0146 -5.8984 -2.0847 -4.3032 -0.9306 0.1731 6.3716 3.7485 0.8735 3.5197 0.1985 0.2402 5.7867 1.5016</span> -<span class="r-out co"><span class="r-pr">#></span> 270: 93.0159 -5.8950 -2.0842 -4.3013 -0.9307 0.1722 6.3630 3.7266 0.8743 3.5098 0.1986 0.2400 5.7837 1.5016</span> -<span class="r-out co"><span class="r-pr">#></span> 271: 93.0161 -5.8925 -2.0837 -4.2995 -0.9309 0.1715 6.3539 3.7068 0.8744 3.5001 0.1986 0.2400 5.7843 1.5020</span> -<span class="r-out co"><span class="r-pr">#></span> 272: 93.0195 -5.8919 -2.0837 -4.2977 -0.9314 0.1710 6.3430 3.6964 0.8744 3.4922 0.1985 0.2400 5.7859 1.5031</span> -<span class="r-out co"><span class="r-pr">#></span> 273: 93.0184 -5.8923 -2.0837 -4.2961 -0.9318 0.1705 6.3531 3.6914 0.8743 3.4854 0.1984 0.2402 5.7880 1.5030</span> -<span class="r-out co"><span class="r-pr">#></span> 274: 93.0178 -5.8927 -2.0834 -4.2951 -0.9320 0.1701 6.3818 3.6865 0.8749 3.4824 0.1984 0.2403 5.7928 1.5020</span> -<span class="r-out co"><span class="r-pr">#></span> 275: 93.0204 -5.8937 -2.0833 -4.2942 -0.9324 0.1700 6.3961 3.6842 0.8754 3.4790 0.1984 0.2402 5.7949 1.5011</span> -<span class="r-out co"><span class="r-pr">#></span> 276: 93.0228 -5.8958 -2.0833 -4.2932 -0.9327 0.1699 6.3965 3.6870 0.8760 3.4752 0.1984 0.2402 5.7934 1.5002</span> -<span class="r-out co"><span class="r-pr">#></span> 277: 93.0251 -5.9000 -2.0833 -4.2921 -0.9329 0.1695 6.4076 3.7032 0.8766 3.4712 0.1985 0.2400 5.7979 1.4989</span> -<span class="r-out co"><span class="r-pr">#></span> 278: 93.0297 -5.9021 -2.0833 -4.2912 -0.9331 0.1690 6.4279 3.7073 0.8771 3.4671 0.1986 0.2399 5.7978 1.4981</span> -<span class="r-out co"><span class="r-pr">#></span> 279: 93.0273 -5.9021 -2.0832 -4.2902 -0.9332 0.1684 6.4349 3.7003 0.8779 3.4622 0.1988 0.2400 5.7993 1.4972</span> -<span class="r-out co"><span class="r-pr">#></span> 280: 93.0236 -5.9030 -2.0831 -4.2892 -0.9334 0.1674 6.4776 3.6986 0.8787 3.4576 0.1990 0.2401 5.8026 1.4963</span> -<span class="r-out co"><span class="r-pr">#></span> 281: 93.0172 -5.9037 -2.0829 -4.2881 -0.9337 0.1665 6.4942 3.6984 0.8797 3.4536 0.1992 0.2402 5.8056 1.4955</span> -<span class="r-out co"><span class="r-pr">#></span> 282: 93.0147 -5.9055 -2.0827 -4.2872 -0.9339 0.1656 6.4861 3.7031 0.8810 3.4492 0.1992 0.2403 5.8107 1.4954</span> -<span class="r-out co"><span class="r-pr">#></span> 283: 93.0138 -5.9053 -2.0824 -4.2865 -0.9341 0.1646 6.4962 3.6967 0.8822 3.4451 0.1993 0.2406 5.8142 1.4959</span> -<span class="r-out co"><span class="r-pr">#></span> 284: 93.0132 -5.9067 -2.0821 -4.2864 -0.9343 0.1636 6.5021 3.7013 0.8838 3.4437 0.1993 0.2406 5.8146 1.4955</span> -<span class="r-out co"><span class="r-pr">#></span> 285: 93.0138 -5.9081 -2.0819 -4.2859 -0.9343 0.1628 6.5037 3.7043 0.8851 3.4406 0.1994 0.2406 5.8146 1.4945</span> -<span class="r-out co"><span class="r-pr">#></span> 286: 93.0119 -5.9086 -2.0815 -4.2858 -0.9342 0.1620 6.5068 3.7037 0.8864 3.4395 0.1994 0.2404 5.8133 1.4936</span> -<span class="r-out co"><span class="r-pr">#></span> 287: 93.0122 -5.9089 -2.0813 -4.2860 -0.9342 0.1614 6.5202 3.7044 0.8872 3.4399 0.1997 0.2401 5.8096 1.4929</span> -<span class="r-out co"><span class="r-pr">#></span> 288: 93.0104 -5.9083 -2.0812 -4.2858 -0.9342 0.1609 6.5237 3.6997 0.8876 3.4376 0.1999 0.2398 5.8041 1.4924</span> -<span class="r-out co"><span class="r-pr">#></span> 289: 93.0076 -5.9066 -2.0812 -4.2854 -0.9342 0.1604 6.5121 3.6893 0.8881 3.4342 0.1999 0.2394 5.8021 1.4922</span> -<span class="r-out co"><span class="r-pr">#></span> 290: 93.0064 -5.9052 -2.0813 -4.2851 -0.9343 0.1602 6.5106 3.6772 0.8886 3.4309 0.2000 0.2389 5.7988 1.4915</span> -<span class="r-out co"><span class="r-pr">#></span> 291: 93.0071 -5.9031 -2.0813 -4.2849 -0.9345 0.1601 6.5031 3.6628 0.8891 3.4284 0.2000 0.2384 5.7959 1.4908</span> -<span class="r-out co"><span class="r-pr">#></span> 292: 93.0114 -5.9023 -2.0809 -4.2841 -0.9346 0.1594 6.4930 3.6538 0.8894 3.4237 0.2001 0.2383 5.7923 1.4902</span> -<span class="r-out co"><span class="r-pr">#></span> 293: 93.0148 -5.9032 -2.0807 -4.2834 -0.9348 0.1589 6.4836 3.6542 0.8898 3.4206 0.2002 0.2380 5.7893 1.4893</span> -<span class="r-out co"><span class="r-pr">#></span> 294: 93.0161 -5.9026 -2.0806 -4.2826 -0.9349 0.1582 6.4719 3.6469 0.8901 3.4176 0.2005 0.2375 5.7898 1.4886</span> -<span class="r-out co"><span class="r-pr">#></span> 295: 93.0212 -5.9008 -2.0806 -4.2817 -0.9350 0.1576 6.4649 3.6372 0.8904 3.4145 0.2007 0.2370 5.7885 1.4890</span> -<span class="r-out co"><span class="r-pr">#></span> 296: 93.0270 -5.8989 -2.0805 -4.2809 -0.9351 0.1569 6.4835 3.6279 0.8911 3.4124 0.2010 0.2366 5.7886 1.4884</span> -<span class="r-out co"><span class="r-pr">#></span> 297: 93.0291 -5.8969 -2.0803 -4.2800 -0.9352 0.1560 6.5014 3.6177 0.8915 3.4094 0.2012 0.2364 5.7873 1.4880</span> -<span class="r-out co"><span class="r-pr">#></span> 298: 93.0332 -5.8963 -2.0801 -4.2790 -0.9352 0.1551 6.5168 3.6111 0.8919 3.4065 0.2014 0.2361 5.7855 1.4875</span> -<span class="r-out co"><span class="r-pr">#></span> 299: 93.0339 -5.8961 -2.0799 -4.2782 -0.9352 0.1542 6.5288 3.6081 0.8927 3.4038 0.2015 0.2358 5.7844 1.4869</span> -<span class="r-out co"><span class="r-pr">#></span> 300: 93.0335 -5.8971 -2.0797 -4.2772 -0.9351 0.1533 6.5409 3.6097 0.8937 3.4009 0.2017 0.2356 5.7844 1.4859</span> -<span class="r-out co"><span class="r-pr">#></span> 301: 93.0320 -5.8979 -2.0796 -4.2762 -0.9350 0.1522 6.5553 3.6126 0.8945 3.3977 0.2020 0.2354 5.7898 1.4847</span> -<span class="r-out co"><span class="r-pr">#></span> 302: 93.0321 -5.8997 -2.0795 -4.2751 -0.9351 0.1513 6.5737 3.6195 0.8956 3.3943 0.2023 0.2351 5.7917 1.4835</span> -<span class="r-out co"><span class="r-pr">#></span> 303: 93.0328 -5.8984 -2.0792 -4.2739 -0.9351 0.1504 6.5888 3.6111 0.8964 3.3912 0.2025 0.2350 5.7915 1.4825</span> -<span class="r-out co"><span class="r-pr">#></span> 304: 93.0357 -5.8969 -2.0790 -4.2728 -0.9350 0.1494 6.5907 3.6018 0.8975 3.3882 0.2026 0.2348 5.7929 1.4813</span> -<span class="r-out co"><span class="r-pr">#></span> 305: 93.0351 -5.8953 -2.0786 -4.2718 -0.9349 0.1484 6.5764 3.5916 0.8986 3.3858 0.2027 0.2345 5.7937 1.4816</span> -<span class="r-out co"><span class="r-pr">#></span> 306: 93.0352 -5.8950 -2.0784 -4.2707 -0.9350 0.1475 6.5727 3.5890 0.8999 3.3835 0.2028 0.2341 5.7981 1.4810</span> -<span class="r-out co"><span class="r-pr">#></span> 307: 93.0354 -5.8947 -2.0784 -4.2699 -0.9351 0.1466 6.5759 3.5853 0.9010 3.3820 0.2030 0.2339 5.8028 1.4799</span> -<span class="r-out co"><span class="r-pr">#></span> 308: 93.0336 -5.8938 -2.0783 -4.2690 -0.9351 0.1459 6.5855 3.5776 0.9022 3.3809 0.2031 0.2333 5.8014 1.4788</span> -<span class="r-out co"><span class="r-pr">#></span> 309: 93.0311 -5.8931 -2.0780 -4.2683 -0.9351 0.1452 6.5799 3.5717 0.9038 3.3805 0.2033 0.2328 5.8048 1.4779</span> -<span class="r-out co"><span class="r-pr">#></span> 310: 93.0303 -5.8915 -2.0778 -4.2675 -0.9352 0.1447 6.5716 3.5609 0.9046 3.3797 0.2033 0.2323 5.8060 1.4774</span> -<span class="r-out co"><span class="r-pr">#></span> 311: 93.0275 -5.8915 -2.0776 -4.2668 -0.9352 0.1441 6.5679 3.5581 0.9052 3.3788 0.2034 0.2319 5.8056 1.4770</span> -<span class="r-out co"><span class="r-pr">#></span> 312: 93.0258 -5.8920 -2.0775 -4.2659 -0.9352 0.1435 6.5573 3.5571 0.9058 3.3775 0.2033 0.2314 5.8053 1.4766</span> -<span class="r-out co"><span class="r-pr">#></span> 313: 93.0234 -5.8928 -2.0773 -4.2649 -0.9353 0.1431 6.5510 3.5573 0.9065 3.3761 0.2033 0.2309 5.8046 1.4757</span> -<span class="r-out co"><span class="r-pr">#></span> 314: 93.0237 -5.8937 -2.0771 -4.2639 -0.9355 0.1425 6.5488 3.5578 0.9074 3.3747 0.2033 0.2303 5.8029 1.4751</span> -<span class="r-out co"><span class="r-pr">#></span> 315: 93.0237 -5.8940 -2.0769 -4.2629 -0.9357 0.1420 6.5480 3.5565 0.9081 3.3730 0.2034 0.2299 5.8010 1.4746</span> -<span class="r-out co"><span class="r-pr">#></span> 316: 93.0218 -5.8936 -2.0767 -4.2617 -0.9358 0.1413 6.5424 3.5517 0.9087 3.3705 0.2034 0.2296 5.7992 1.4741</span> -<span class="r-out co"><span class="r-pr">#></span> 317: 93.0218 -5.8932 -2.0766 -4.2606 -0.9359 0.1406 6.5576 3.5474 0.9091 3.3679 0.2034 0.2292 5.7965 1.4736</span> -<span class="r-out co"><span class="r-pr">#></span> 318: 93.0215 -5.8927 -2.0765 -4.2597 -0.9361 0.1402 6.5884 3.5420 0.9096 3.3661 0.2034 0.2288 5.7960 1.4727</span> -<span class="r-out co"><span class="r-pr">#></span> 319: 93.0201 -5.8938 -2.0764 -4.2588 -0.9361 0.1397 6.6095 3.5439 0.9101 3.3642 0.2034 0.2283 5.7943 1.4719</span> -<span class="r-out co"><span class="r-pr">#></span> 320: 93.0188 -5.8926 -2.0763 -4.2579 -0.9361 0.1392 6.6170 3.5368 0.9103 3.3622 0.2034 0.2282 5.7930 1.4711</span> -<span class="r-out co"><span class="r-pr">#></span> 321: 93.0155 -5.8908 -2.0762 -4.2569 -0.9361 0.1385 6.6328 3.5268 0.9105 3.3598 0.2033 0.2282 5.7921 1.4702</span> -<span class="r-out co"><span class="r-pr">#></span> 322: 93.0133 -5.8894 -2.0760 -4.2561 -0.9360 0.1378 6.6415 3.5192 0.9110 3.3580 0.2032 0.2282 5.7903 1.4698</span> -<span class="r-out co"><span class="r-pr">#></span> 323: 93.0089 -5.8888 -2.0759 -4.2555 -0.9360 0.1372 6.6480 3.5131 0.9107 3.3563 0.2031 0.2285 5.7915 1.4691</span> -<span class="r-out co"><span class="r-pr">#></span> 324: 93.0038 -5.8881 -2.0758 -4.2547 -0.9359 0.1364 6.6639 3.5076 0.9106 3.3547 0.2029 0.2287 5.7912 1.4687</span> -<span class="r-out co"><span class="r-pr">#></span> 325: 93.0011 -5.8871 -2.0756 -4.2540 -0.9359 0.1361 6.6587 3.5005 0.9102 3.3531 0.2028 0.2289 5.7896 1.4686</span> -<span class="r-out co"><span class="r-pr">#></span> 326: 93.0033 -5.8874 -2.0755 -4.2535 -0.9360 0.1360 6.6621 3.4995 0.9098 3.3510 0.2026 0.2294 5.7883 1.4686</span> -<span class="r-out co"><span class="r-pr">#></span> 327: 93.0039 -5.8885 -2.0754 -4.2532 -0.9361 0.1359 6.6589 3.5051 0.9093 3.3497 0.2025 0.2297 5.7869 1.4687</span> -<span class="r-out co"><span class="r-pr">#></span> 328: 93.0061 -5.8896 -2.0753 -4.2529 -0.9362 0.1355 6.6671 3.5132 0.9088 3.3484 0.2024 0.2299 5.7854 1.4687</span> -<span class="r-out co"><span class="r-pr">#></span> 329: 93.0077 -5.8915 -2.0755 -4.2525 -0.9363 0.1352 6.6719 3.5255 0.9085 3.3464 0.2024 0.2301 5.7850 1.4682</span> -<span class="r-out co"><span class="r-pr">#></span> 330: 93.0061 -5.8942 -2.0757 -4.2518 -0.9365 0.1351 6.6696 3.5399 0.9083 3.3438 0.2023 0.2302 5.7840 1.4680</span> -<span class="r-out co"><span class="r-pr">#></span> 331: 93.0032 -5.8953 -2.0759 -4.2513 -0.9366 0.1348 6.6554 3.5433 0.9080 3.3411 0.2022 0.2302 5.7839 1.4677</span> -<span class="r-out co"><span class="r-pr">#></span> 332: 93.0013 -5.8956 -2.0761 -4.2507 -0.9367 0.1347 6.6298 3.5423 0.9079 3.3385 0.2021 0.2302 5.7851 1.4672</span> -<span class="r-out co"><span class="r-pr">#></span> 333: 93.0026 -5.8950 -2.0764 -4.2502 -0.9368 0.1346 6.6207 3.5365 0.9078 3.3357 0.2021 0.2303 5.7849 1.4667</span> -<span class="r-out co"><span class="r-pr">#></span> 334: 93.0019 -5.8933 -2.0767 -4.2497 -0.9369 0.1348 6.6145 3.5259 0.9077 3.3330 0.2021 0.2302 5.7856 1.4662</span> -<span class="r-out co"><span class="r-pr">#></span> 335: 93.0038 -5.8930 -2.0768 -4.2492 -0.9370 0.1348 6.6200 3.5227 0.9078 3.3307 0.2020 0.2303 5.7845 1.4654</span> -<span class="r-out co"><span class="r-pr">#></span> 336: 93.0038 -5.8923 -2.0765 -4.2488 -0.9371 0.1348 6.6316 3.5180 0.9081 3.3291 0.2019 0.2304 5.7837 1.4654</span> -<span class="r-out co"><span class="r-pr">#></span> 337: 93.0074 -5.8927 -2.0764 -4.2485 -0.9373 0.1349 6.6509 3.5187 0.9083 3.3275 0.2018 0.2304 5.7808 1.4655</span> -<span class="r-out co"><span class="r-pr">#></span> 338: 93.0117 -5.8950 -2.0761 -4.2483 -0.9377 0.1349 6.6559 3.5291 0.9087 3.3263 0.2018 0.2303 5.7770 1.4657</span> -<span class="r-out co"><span class="r-pr">#></span> 339: 93.0172 -5.8960 -2.0759 -4.2482 -0.9380 0.1349 6.6610 3.5304 0.9090 3.3260 0.2017 0.2302 5.7744 1.4657</span> -<span class="r-out co"><span class="r-pr">#></span> 340: 93.0179 -5.8977 -2.0757 -4.2481 -0.9383 0.1349 6.6583 3.5340 0.9093 3.3263 0.2017 0.2301 5.7749 1.4650</span> -<span class="r-out co"><span class="r-pr">#></span> 341: 93.0201 -5.8986 -2.0755 -4.2484 -0.9386 0.1348 6.6603 3.5337 0.9092 3.3283 0.2018 0.2300 5.7738 1.4650</span> -<span class="r-out co"><span class="r-pr">#></span> 342: 93.0245 -5.8990 -2.0752 -4.2484 -0.9389 0.1348 6.6680 3.5324 0.9093 3.3297 0.2018 0.2300 5.7727 1.4649</span> -<span class="r-out co"><span class="r-pr">#></span> 343: 93.0302 -5.9006 -2.0751 -4.2484 -0.9391 0.1347 6.6715 3.5367 0.9093 3.3313 0.2017 0.2300 5.7729 1.4645</span> -<span class="r-out co"><span class="r-pr">#></span> 344: 93.0340 -5.9026 -2.0749 -4.2484 -0.9394 0.1346 6.6793 3.5438 0.9093 3.3326 0.2017 0.2301 5.7709 1.4646</span> -<span class="r-out co"><span class="r-pr">#></span> 345: 93.0372 -5.9049 -2.0746 -4.2484 -0.9397 0.1347 6.6874 3.5515 0.9090 3.3340 0.2017 0.2301 5.7688 1.4648</span> -<span class="r-out co"><span class="r-pr">#></span> 346: 93.0372 -5.9063 -2.0743 -4.2483 -0.9399 0.1348 6.6963 3.5592 0.9090 3.3348 0.2018 0.2299 5.7680 1.4656</span> -<span class="r-out co"><span class="r-pr">#></span> 347: 93.0383 -5.9075 -2.0742 -4.2481 -0.9402 0.1350 6.7101 3.5658 0.9093 3.3353 0.2018 0.2299 5.7672 1.4649</span> -<span class="r-out co"><span class="r-pr">#></span> 348: 93.0412 -5.9084 -2.0742 -4.2479 -0.9405 0.1351 6.7183 3.5707 0.9095 3.3356 0.2019 0.2297 5.7657 1.4645</span> -<span class="r-out co"><span class="r-pr">#></span> 349: 93.0436 -5.9097 -2.0742 -4.2477 -0.9407 0.1351 6.7143 3.5783 0.9098 3.3359 0.2019 0.2295 5.7646 1.4643</span> -<span class="r-out co"><span class="r-pr">#></span> 350: 93.0476 -5.9105 -2.0742 -4.2474 -0.9409 0.1351 6.7239 3.5808 0.9100 3.3354 0.2019 0.2294 5.7628 1.4639</span> -<span class="r-out co"><span class="r-pr">#></span> 351: 93.0506 -5.9113 -2.0741 -4.2473 -0.9411 0.1352 6.7270 3.5825 0.9103 3.3356 0.2019 0.2292 5.7604 1.4637</span> -<span class="r-out co"><span class="r-pr">#></span> 352: 93.0529 -5.9127 -2.0740 -4.2471 -0.9413 0.1353 6.7312 3.5886 0.9107 3.3358 0.2019 0.2290 5.7594 1.4634</span> -<span class="r-out co"><span class="r-pr">#></span> 353: 93.0580 -5.9139 -2.0739 -4.2470 -0.9415 0.1354 6.7315 3.5922 0.9111 3.3357 0.2019 0.2288 5.7571 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 354: 93.0639 -5.9129 -2.0738 -4.2468 -0.9417 0.1354 6.7390 3.5876 0.9112 3.3356 0.2018 0.2286 5.7541 1.4642</span> -<span class="r-out co"><span class="r-pr">#></span> 355: 93.0671 -5.9131 -2.0737 -4.2467 -0.9417 0.1353 6.7348 3.5906 0.9113 3.3354 0.2017 0.2284 5.7520 1.4648</span> -<span class="r-out co"><span class="r-pr">#></span> 356: 93.0682 -5.9134 -2.0737 -4.2465 -0.9418 0.1352 6.7329 3.5962 0.9113 3.3353 0.2017 0.2283 5.7505 1.4649</span> -<span class="r-out co"><span class="r-pr">#></span> 357: 93.0698 -5.9128 -2.0738 -4.2471 -0.9418 0.1354 6.7397 3.5933 0.9115 3.3388 0.2016 0.2280 5.7512 1.4651</span> -<span class="r-out co"><span class="r-pr">#></span> 358: 93.0709 -5.9129 -2.0740 -4.2475 -0.9419 0.1355 6.7379 3.5915 0.9119 3.3416 0.2016 0.2278 5.7526 1.4644</span> -<span class="r-out co"><span class="r-pr">#></span> 359: 93.0718 -5.9128 -2.0742 -4.2478 -0.9419 0.1358 6.7428 3.5886 0.9123 3.3432 0.2015 0.2275 5.7516 1.4641</span> -<span class="r-out co"><span class="r-pr">#></span> 360: 93.0693 -5.9136 -2.0743 -4.2481 -0.9419 0.1360 6.7385 3.5930 0.9125 3.3443 0.2015 0.2272 5.7511 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 361: 93.0674 -5.9148 -2.0744 -4.2484 -0.9419 0.1361 6.7230 3.6002 0.9127 3.3458 0.2015 0.2270 5.7514 1.4634</span> -<span class="r-out co"><span class="r-pr">#></span> 362: 93.0660 -5.9168 -2.0745 -4.2486 -0.9420 0.1361 6.7313 3.6117 0.9130 3.3473 0.2014 0.2270 5.7506 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 363: 93.0635 -5.9196 -2.0746 -4.2490 -0.9421 0.1360 6.7388 3.6275 0.9132 3.3500 0.2014 0.2269 5.7493 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 364: 93.0631 -5.9210 -2.0747 -4.2497 -0.9421 0.1361 6.7383 3.6323 0.9135 3.3548 0.2015 0.2268 5.7483 1.4634</span> -<span class="r-out co"><span class="r-pr">#></span> 365: 93.0635 -5.9219 -2.0747 -4.2504 -0.9421 0.1361 6.7402 3.6341 0.9137 3.3590 0.2015 0.2268 5.7461 1.4635</span> -<span class="r-out co"><span class="r-pr">#></span> 366: 93.0640 -5.9232 -2.0746 -4.2511 -0.9422 0.1362 6.7477 3.6409 0.9142 3.3624 0.2015 0.2267 5.7451 1.4641</span> -<span class="r-out co"><span class="r-pr">#></span> 367: 93.0616 -5.9247 -2.0746 -4.2518 -0.9422 0.1364 6.7557 3.6473 0.9148 3.3653 0.2015 0.2269 5.7472 1.4640</span> -<span class="r-out co"><span class="r-pr">#></span> 368: 93.0601 -5.9247 -2.0746 -4.2522 -0.9422 0.1366 6.7632 3.6452 0.9150 3.3678 0.2015 0.2270 5.7482 1.4639</span> -<span class="r-out co"><span class="r-pr">#></span> 369: 93.0583 -5.9240 -2.0748 -4.2527 -0.9423 0.1369 6.7737 3.6395 0.9148 3.3695 0.2015 0.2273 5.7499 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 370: 93.0591 -5.9236 -2.0752 -4.2532 -0.9423 0.1373 6.7721 3.6352 0.9145 3.3718 0.2015 0.2276 5.7513 1.4636</span> -<span class="r-out co"><span class="r-pr">#></span> 371: 93.0607 -5.9235 -2.0755 -4.2540 -0.9424 0.1378 6.7682 3.6330 0.9143 3.3754 0.2015 0.2280 5.7535 1.4635</span> -<span class="r-out co"><span class="r-pr">#></span> 372: 93.0615 -5.9229 -2.0759 -4.2549 -0.9424 0.1382 6.7640 3.6288 0.9142 3.3795 0.2014 0.2284 5.7553 1.4633</span> -<span class="r-out co"><span class="r-pr">#></span> 373: 93.0612 -5.9237 -2.0763 -4.2557 -0.9424 0.1385 6.7641 3.6327 0.9140 3.3832 0.2012 0.2288 5.7570 1.4629</span> -<span class="r-out co"><span class="r-pr">#></span> 374: 93.0611 -5.9240 -2.0766 -4.2565 -0.9424 0.1389 6.7701 3.6341 0.9137 3.3872 0.2011 0.2293 5.7599 1.4625</span> -<span class="r-out co"><span class="r-pr">#></span> 375: 93.0615 -5.9247 -2.0770 -4.2573 -0.9424 0.1393 6.7729 3.6362 0.9134 3.3912 0.2009 0.2296 5.7629 1.4620</span> -<span class="r-out co"><span class="r-pr">#></span> 376: 93.0621 -5.9248 -2.0772 -4.2578 -0.9425 0.1397 6.7732 3.6371 0.9132 3.3931 0.2008 0.2298 5.7654 1.4613</span> -<span class="r-out co"><span class="r-pr">#></span> 377: 93.0622 -5.9255 -2.0774 -4.2582 -0.9426 0.1401 6.7681 3.6389 0.9130 3.3953 0.2007 0.2300 5.7678 1.4607</span> -<span class="r-out co"><span class="r-pr">#></span> 378: 93.0609 -5.9256 -2.0775 -4.2585 -0.9426 0.1402 6.7705 3.6381 0.9128 3.3972 0.2006 0.2301 5.7673 1.4602</span> -<span class="r-out co"><span class="r-pr">#></span> 379: 93.0590 -5.9262 -2.0776 -4.2589 -0.9426 0.1404 6.7777 3.6382 0.9127 3.3991 0.2005 0.2303 5.7668 1.4599</span> -<span class="r-out co"><span class="r-pr">#></span> 380: 93.0607 -5.9258 -2.0777 -4.2595 -0.9427 0.1407 6.7836 3.6350 0.9127 3.4031 0.2004 0.2305 5.7665 1.4598</span> -<span class="r-out co"><span class="r-pr">#></span> 381: 93.0617 -5.9251 -2.0777 -4.2596 -0.9427 0.1410 6.7880 3.6294 0.9125 3.4030 0.2003 0.2307 5.7651 1.4601</span> -<span class="r-out co"><span class="r-pr">#></span> 382: 93.0631 -5.9252 -2.0777 -4.2599 -0.9428 0.1413 6.7912 3.6278 0.9123 3.4038 0.2002 0.2310 5.7649 1.4606</span> -<span class="r-out co"><span class="r-pr">#></span> 383: 93.0621 -5.9253 -2.0778 -4.2602 -0.9429 0.1415 6.7834 3.6279 0.9119 3.4053 0.2000 0.2312 5.7657 1.4607</span> -<span class="r-out co"><span class="r-pr">#></span> 384: 93.0614 -5.9254 -2.0779 -4.2604 -0.9430 0.1416 6.7853 3.6280 0.9115 3.4066 0.1999 0.2313 5.7662 1.4608</span> -<span class="r-out co"><span class="r-pr">#></span> 385: 93.0613 -5.9259 -2.0780 -4.2605 -0.9430 0.1418 6.7757 3.6301 0.9112 3.4066 0.1997 0.2315 5.7678 1.4609</span> -<span class="r-out co"><span class="r-pr">#></span> 386: 93.0614 -5.9264 -2.0780 -4.2607 -0.9431 0.1418 6.7610 3.6331 0.9110 3.4073 0.1995 0.2317 5.7696 1.4612</span> -<span class="r-out co"><span class="r-pr">#></span> 387: 93.0631 -5.9276 -2.0780 -4.2610 -0.9432 0.1420 6.7595 3.6397 0.9108 3.4085 0.1993 0.2318 5.7716 1.4612</span> -<span class="r-out co"><span class="r-pr">#></span> 388: 93.0650 -5.9282 -2.0779 -4.2613 -0.9433 0.1421 6.7552 3.6445 0.9106 3.4092 0.1992 0.2318 5.7731 1.4612</span> -<span class="r-out co"><span class="r-pr">#></span> 389: 93.0644 -5.9286 -2.0779 -4.2616 -0.9434 0.1422 6.7488 3.6471 0.9104 3.4098 0.1991 0.2317 5.7724 1.4614</span> -<span class="r-out co"><span class="r-pr">#></span> 390: 93.0653 -5.9297 -2.0778 -4.2619 -0.9435 0.1423 6.7412 3.6524 0.9101 3.4103 0.1990 0.2317 5.7722 1.4615</span> -<span class="r-out co"><span class="r-pr">#></span> 391: 93.0647 -5.9297 -2.0778 -4.2623 -0.9435 0.1425 6.7508 3.6524 0.9101 3.4115 0.1989 0.2317 5.7729 1.4621</span> -<span class="r-out co"><span class="r-pr">#></span> 392: 93.0637 -5.9293 -2.0778 -4.2624 -0.9436 0.1427 6.7572 3.6498 0.9102 3.4109 0.1988 0.2317 5.7727 1.4623</span> -<span class="r-out co"><span class="r-pr">#></span> 393: 93.0657 -5.9294 -2.0778 -4.2632 -0.9436 0.1429 6.7607 3.6496 0.9104 3.4148 0.1987 0.2318 5.7719 1.4621</span> -<span class="r-out co"><span class="r-pr">#></span> 394: 93.0689 -5.9293 -2.0779 -4.2635 -0.9438 0.1431 6.7635 3.6489 0.9108 3.4141 0.1987 0.2318 5.7724 1.4623</span> -<span class="r-out co"><span class="r-pr">#></span> 395: 93.0705 -5.9295 -2.0780 -4.2640 -0.9438 0.1433 6.7753 3.6500 0.9110 3.4145 0.1986 0.2319 5.7724 1.4622</span> -<span class="r-out co"><span class="r-pr">#></span> 396: 93.0704 -5.9296 -2.0780 -4.2648 -0.9438 0.1435 6.7793 3.6511 0.9112 3.4175 0.1985 0.2319 5.7720 1.4618</span> -<span class="r-out co"><span class="r-pr">#></span> 397: 93.0715 -5.9302 -2.0781 -4.2656 -0.9438 0.1437 6.7782 3.6530 0.9114 3.4206 0.1985 0.2320 5.7706 1.4617</span> -<span class="r-out co"><span class="r-pr">#></span> 398: 93.0719 -5.9297 -2.0781 -4.2666 -0.9438 0.1439 6.7774 3.6510 0.9120 3.4258 0.1984 0.2319 5.7709 1.4616</span> -<span class="r-out co"><span class="r-pr">#></span> 399: 93.0720 -5.9296 -2.0781 -4.2678 -0.9438 0.1441 6.7819 3.6526 0.9126 3.4317 0.1984 0.2319 5.7717 1.4615</span> -<span class="r-out co"><span class="r-pr">#></span> 400: 93.0730 -5.9296 -2.0783 -4.2691 -0.9438 0.1443 6.7786 3.6538 0.9129 3.4389 0.1983 0.2319 5.7716 1.4614</span> -<span class="r-out co"><span class="r-pr">#></span> 401: 93.0728 -5.9292 -2.0783 -4.2706 -0.9437 0.1445 6.7731 3.6521 0.9133 3.4478 0.1982 0.2319 5.7701 1.4615</span> -<span class="r-out co"><span class="r-pr">#></span> 402: 93.0732 -5.9289 -2.0784 -4.2718 -0.9438 0.1447 6.7698 3.6517 0.9137 3.4542 0.1981 0.2319 5.7689 1.4618</span> -<span class="r-out co"><span class="r-pr">#></span> 403: 93.0732 -5.9301 -2.0785 -4.2730 -0.9438 0.1450 6.7640 3.6576 0.9142 3.4593 0.1980 0.2320 5.7693 1.4615</span> -<span class="r-out co"><span class="r-pr">#></span> 404: 93.0710 -5.9316 -2.0787 -4.2740 -0.9439 0.1453 6.7544 3.6647 0.9147 3.4644 0.1979 0.2320 5.7708 1.4611</span> -<span class="r-out co"><span class="r-pr">#></span> 405: 93.0687 -5.9322 -2.0788 -4.2750 -0.9440 0.1454 6.7547 3.6663 0.9153 3.4693 0.1978 0.2322 5.7714 1.4608</span> -<span class="r-out co"><span class="r-pr">#></span> 406: 93.0673 -5.9337 -2.0789 -4.2760 -0.9440 0.1456 6.7563 3.6726 0.9163 3.4742 0.1977 0.2324 5.7718 1.4603</span> -<span class="r-out co"><span class="r-pr">#></span> 407: 93.0653 -5.9345 -2.0791 -4.2769 -0.9440 0.1456 6.7601 3.6756 0.9169 3.4786 0.1976 0.2327 5.7732 1.4598</span> -<span class="r-out co"><span class="r-pr">#></span> 408: 93.0640 -5.9357 -2.0793 -4.2779 -0.9440 0.1455 6.7547 3.6821 0.9177 3.4838 0.1974 0.2329 5.7751 1.4592</span> -<span class="r-out co"><span class="r-pr">#></span> 409: 93.0646 -5.9371 -2.0795 -4.2784 -0.9440 0.1456 6.7486 3.6915 0.9184 3.4863 0.1973 0.2330 5.7766 1.4588</span> -<span class="r-out co"><span class="r-pr">#></span> 410: 93.0639 -5.9391 -2.0797 -4.2791 -0.9441 0.1457 6.7523 3.7048 0.9192 3.4889 0.1972 0.2329 5.7770 1.4582</span> -<span class="r-out co"><span class="r-pr">#></span> 411: 93.0628 -5.9401 -2.0799 -4.2799 -0.9442 0.1457 6.7529 3.7113 0.9199 3.4929 0.1972 0.2329 5.7761 1.4580</span> -<span class="r-out co"><span class="r-pr">#></span> 412: 93.0620 -5.9402 -2.0801 -4.2808 -0.9443 0.1458 6.7502 3.7099 0.9207 3.4972 0.1971 0.2328 5.7767 1.4577</span> -<span class="r-out co"><span class="r-pr">#></span> 413: 93.0628 -5.9403 -2.0804 -4.2816 -0.9443 0.1461 6.7466 3.7091 0.9214 3.5007 0.1970 0.2326 5.7771 1.4572</span> -<span class="r-out co"><span class="r-pr">#></span> 414: 93.0627 -5.9405 -2.0807 -4.2825 -0.9443 0.1463 6.7480 3.7089 0.9221 3.5048 0.1969 0.2325 5.7774 1.4567</span> -<span class="r-out co"><span class="r-pr">#></span> 415: 93.0614 -5.9402 -2.0810 -4.2836 -0.9443 0.1465 6.7474 3.7066 0.9226 3.5098 0.1969 0.2323 5.7780 1.4564</span> -<span class="r-out co"><span class="r-pr">#></span> 416: 93.0610 -5.9408 -2.0813 -4.2848 -0.9443 0.1469 6.7544 3.7116 0.9229 3.5157 0.1968 0.2321 5.7786 1.4559</span> -<span class="r-out co"><span class="r-pr">#></span> 417: 93.0601 -5.9413 -2.0815 -4.2860 -0.9443 0.1471 6.7592 3.7158 0.9234 3.5206 0.1967 0.2319 5.7793 1.4556</span> -<span class="r-out co"><span class="r-pr">#></span> 418: 93.0606 -5.9424 -2.0817 -4.2868 -0.9444 0.1473 6.7589 3.7214 0.9238 3.5237 0.1966 0.2318 5.7787 1.4553</span> -<span class="r-out co"><span class="r-pr">#></span> 419: 93.0605 -5.9433 -2.0818 -4.2877 -0.9444 0.1476 6.7641 3.7253 0.9242 3.5274 0.1965 0.2316 5.7780 1.4552</span> -<span class="r-out co"><span class="r-pr">#></span> 420: 93.0623 -5.9427 -2.0819 -4.2886 -0.9445 0.1478 6.7593 3.7216 0.9246 3.5310 0.1965 0.2314 5.7772 1.4551</span> -<span class="r-out co"><span class="r-pr">#></span> 421: 93.0630 -5.9418 -2.0819 -4.2895 -0.9445 0.1480 6.7489 3.7166 0.9250 3.5337 0.1964 0.2312 5.7764 1.4552</span> -<span class="r-out co"><span class="r-pr">#></span> 422: 93.0626 -5.9410 -2.0820 -4.2900 -0.9445 0.1482 6.7452 3.7124 0.9253 3.5350 0.1963 0.2311 5.7758 1.4549</span> -<span class="r-out co"><span class="r-pr">#></span> 423: 93.0629 -5.9407 -2.0822 -4.2906 -0.9446 0.1484 6.7409 3.7095 0.9256 3.5360 0.1963 0.2309 5.7753 1.4546</span> -<span class="r-out co"><span class="r-pr">#></span> 424: 93.0637 -5.9404 -2.0821 -4.2912 -0.9446 0.1485 6.7387 3.7073 0.9258 3.5370 0.1962 0.2308 5.7733 1.4546</span> -<span class="r-out co"><span class="r-pr">#></span> 425: 93.0625 -5.9402 -2.0821 -4.2917 -0.9447 0.1486 6.7330 3.7061 0.9258 3.5381 0.1961 0.2306 5.7722 1.4548</span> -<span class="r-out co"><span class="r-pr">#></span> 426: 93.0624 -5.9399 -2.0820 -4.2921 -0.9447 0.1487 6.7256 3.7034 0.9259 3.5387 0.1961 0.2304 5.7719 1.4545</span> -<span class="r-out co"><span class="r-pr">#></span> 427: 93.0606 -5.9397 -2.0821 -4.2925 -0.9447 0.1488 6.7139 3.7010 0.9257 3.5394 0.1961 0.2301 5.7730 1.4545</span> -<span class="r-out co"><span class="r-pr">#></span> 428: 93.0601 -5.9394 -2.0822 -4.2929 -0.9447 0.1489 6.7062 3.6984 0.9256 3.5405 0.1961 0.2298 5.7723 1.4543</span> -<span class="r-out co"><span class="r-pr">#></span> 429: 93.0615 -5.9391 -2.0821 -4.2933 -0.9447 0.1490 6.7040 3.6956 0.9254 3.5412 0.1960 0.2297 5.7714 1.4544</span> -<span class="r-out co"><span class="r-pr">#></span> 430: 93.0654 -5.9389 -2.0820 -4.2934 -0.9448 0.1491 6.7016 3.6934 0.9253 3.5412 0.1960 0.2295 5.7710 1.4546</span> -<span class="r-out co"><span class="r-pr">#></span> 431: 93.0674 -5.9392 -2.0819 -4.2936 -0.9449 0.1491 6.6946 3.6935 0.9252 3.5414 0.1960 0.2294 5.7699 1.4547</span> -<span class="r-out co"><span class="r-pr">#></span> 432: 93.0683 -5.9401 -2.0818 -4.2938 -0.9450 0.1491 6.6895 3.6960 0.9250 3.5417 0.1961 0.2292 5.7687 1.4549</span> -<span class="r-out co"><span class="r-pr">#></span> 433: 93.0693 -5.9411 -2.0815 -4.2942 -0.9451 0.1491 6.6826 3.7003 0.9254 3.5433 0.1961 0.2291 5.7679 1.4549</span> -<span class="r-out co"><span class="r-pr">#></span> 434: 93.0720 -5.9410 -2.0813 -4.2945 -0.9452 0.1491 6.6842 3.6998 0.9258 3.5440 0.1960 0.2290 5.7662 1.4548</span> -<span class="r-out co"><span class="r-pr">#></span> 435: 93.0735 -5.9417 -2.0811 -4.2947 -0.9453 0.1490 6.6907 3.7029 0.9261 3.5446 0.1960 0.2290 5.7651 1.4548</span> -<span class="r-out co"><span class="r-pr">#></span> 436: 93.0752 -5.9430 -2.0809 -4.2949 -0.9454 0.1489 6.6939 3.7083 0.9266 3.5459 0.1959 0.2290 5.7638 1.4547</span> -<span class="r-out co"><span class="r-pr">#></span> 437: 93.0774 -5.9442 -2.0807 -4.2952 -0.9455 0.1487 6.7016 3.7147 0.9270 3.5474 0.1960 0.2290 5.7624 1.4550</span> -<span class="r-out co"><span class="r-pr">#></span> 438: 93.0795 -5.9453 -2.0805 -4.2954 -0.9456 0.1485 6.7089 3.7212 0.9275 3.5491 0.1959 0.2291 5.7614 1.4551</span> -<span class="r-out co"><span class="r-pr">#></span> 439: 93.0816 -5.9467 -2.0802 -4.2956 -0.9457 0.1484 6.7230 3.7291 0.9281 3.5503 0.1959 0.2293 5.7616 1.4551</span> -<span class="r-out co"><span class="r-pr">#></span> 440: 93.0834 -5.9475 -2.0800 -4.2957 -0.9458 0.1480 6.7306 3.7340 0.9287 3.5512 0.1960 0.2295 5.7631 1.4551</span> -<span class="r-out co"><span class="r-pr">#></span> 441: 93.0855 -5.9480 -2.0797 -4.2961 -0.9459 0.1478 6.7436 3.7373 0.9292 3.5534 0.1960 0.2299 5.7642 1.4553</span> -<span class="r-out co"><span class="r-pr">#></span> 442: 93.0885 -5.9488 -2.0793 -4.2963 -0.9460 0.1474 6.7533 3.7419 0.9297 3.5546 0.1960 0.2304 5.7630 1.4554</span> -<span class="r-out co"><span class="r-pr">#></span> 443: 93.0907 -5.9497 -2.0789 -4.2967 -0.9461 0.1471 6.7641 3.7469 0.9304 3.5570 0.1960 0.2308 5.7616 1.4554</span> -<span class="r-out co"><span class="r-pr">#></span> 444: 93.0905 -5.9504 -2.0785 -4.2972 -0.9462 0.1467 6.7570 3.7486 0.9312 3.5601 0.1960 0.2311 5.7604 1.4553</span> -<span class="r-out co"><span class="r-pr">#></span> 445: 93.0903 -5.9515 -2.0782 -4.2977 -0.9462 0.1462 6.7547 3.7543 0.9319 3.5635 0.1960 0.2314 5.7595 1.4550</span> -<span class="r-out co"><span class="r-pr">#></span> 446: 93.0902 -5.9530 -2.0778 -4.2982 -0.9462 0.1459 6.7562 3.7615 0.9325 3.5664 0.1960 0.2316 5.7580 1.4548</span> -<span class="r-out co"><span class="r-pr">#></span> 447: 93.0905 -5.9541 -2.0775 -4.2990 -0.9463 0.1455 6.7639 3.7668 0.9333 3.5719 0.1960 0.2318 5.7574 1.4543</span> -<span class="r-out co"><span class="r-pr">#></span> 448: 93.0912 -5.9555 -2.0772 -4.2999 -0.9463 0.1452 6.7671 3.7736 0.9340 3.5783 0.1960 0.2322 5.7572 1.4540</span> -<span class="r-out co"><span class="r-pr">#></span> 449: 93.0918 -5.9570 -2.0769 -4.3004 -0.9464 0.1448 6.7824 3.7802 0.9345 3.5809 0.1960 0.2326 5.7561 1.4537</span> -<span class="r-out co"><span class="r-pr">#></span> 450: 93.0901 -5.9579 -2.0766 -4.3011 -0.9464 0.1444 6.7866 3.7829 0.9351 3.5853 0.1959 0.2329 5.7551 1.4536</span> -<span class="r-out co"><span class="r-pr">#></span> 451: 93.0899 -5.9594 -2.0763 -4.3016 -0.9465 0.1439 6.7875 3.7896 0.9356 3.5888 0.1959 0.2332 5.7550 1.4537</span> -<span class="r-out co"><span class="r-pr">#></span> 452: 93.0902 -5.9603 -2.0759 -4.3023 -0.9465 0.1435 6.7953 3.7926 0.9363 3.5927 0.1958 0.2335 5.7537 1.4538</span> -<span class="r-out co"><span class="r-pr">#></span> 453: 93.0906 -5.9615 -2.0755 -4.3026 -0.9465 0.1430 6.7996 3.7982 0.9372 3.5950 0.1958 0.2338 5.7531 1.4539</span> -<span class="r-out co"><span class="r-pr">#></span> 454: 93.0909 -5.9614 -2.0751 -4.3029 -0.9465 0.1425 6.8016 3.7969 0.9381 3.5976 0.1958 0.2340 5.7532 1.4540</span> -<span class="r-out co"><span class="r-pr">#></span> 455: 93.0909 -5.9610 -2.0749 -4.3035 -0.9464 0.1420 6.8022 3.7940 0.9391 3.6022 0.1957 0.2342 5.7532 1.4539</span> -<span class="r-out co"><span class="r-pr">#></span> 456: 93.0916 -5.9600 -2.0746 -4.3045 -0.9463 0.1416 6.7942 3.7893 0.9398 3.6104 0.1957 0.2344 5.7540 1.4537</span> -<span class="r-out co"><span class="r-pr">#></span> 457: 93.0905 -5.9595 -2.0744 -4.3058 -0.9463 0.1411 6.7931 3.7866 0.9407 3.6210 0.1956 0.2345 5.7551 1.4534</span> -<span class="r-out co"><span class="r-pr">#></span> 458: 93.0905 -5.9597 -2.0742 -4.3071 -0.9462 0.1407 6.7877 3.7882 0.9416 3.6327 0.1955 0.2347 5.7566 1.4532</span> -<span class="r-out co"><span class="r-pr">#></span> 459: 93.0895 -5.9598 -2.0741 -4.3078 -0.9461 0.1402 6.7884 3.7889 0.9425 3.6383 0.1955 0.2349 5.7601 1.4527</span> -<span class="r-out co"><span class="r-pr">#></span> 460: 93.0871 -5.9602 -2.0741 -4.3086 -0.9460 0.1398 6.7889 3.7912 0.9434 3.6439 0.1954 0.2350 5.7619 1.4522</span> -<span class="r-out co"><span class="r-pr">#></span> 461: 93.0854 -5.9613 -2.0739 -4.3091 -0.9459 0.1393 6.7813 3.7973 0.9440 3.6481 0.1953 0.2351 5.7620 1.4520</span> -<span class="r-out co"><span class="r-pr">#></span> 462: 93.0838 -5.9623 -2.0737 -4.3093 -0.9458 0.1388 6.7791 3.8037 0.9445 3.6498 0.1953 0.2353 5.7616 1.4518</span> -<span class="r-out co"><span class="r-pr">#></span> 463: 93.0816 -5.9629 -2.0734 -4.3095 -0.9457 0.1384 6.7733 3.8070 0.9451 3.6508 0.1952 0.2355 5.7626 1.4519</span> -<span class="r-out co"><span class="r-pr">#></span> 464: 93.0792 -5.9631 -2.0731 -4.3095 -0.9457 0.1379 6.7697 3.8081 0.9460 3.6507 0.1951 0.2358 5.7638 1.4518</span> -<span class="r-out co"><span class="r-pr">#></span> 465: 93.0775 -5.9633 -2.0728 -4.3095 -0.9456 0.1374 6.7717 3.8095 0.9466 3.6506 0.1950 0.2361 5.7647 1.4519</span> -<span class="r-out co"><span class="r-pr">#></span> 466: 93.0774 -5.9640 -2.0725 -4.3097 -0.9455 0.1368 6.7686 3.8141 0.9473 3.6516 0.1949 0.2363 5.7662 1.4516</span> -<span class="r-out co"><span class="r-pr">#></span> 467: 93.0773 -5.9646 -2.0722 -4.3100 -0.9454 0.1364 6.7668 3.8172 0.9480 3.6535 0.1948 0.2366 5.7671 1.4516</span> -<span class="r-out co"><span class="r-pr">#></span> 468: 93.0777 -5.9653 -2.0719 -4.3106 -0.9453 0.1358 6.7648 3.8226 0.9487 3.6566 0.1947 0.2371 5.7681 1.4514</span> -<span class="r-out co"><span class="r-pr">#></span> 469: 93.0778 -5.9657 -2.0717 -4.3112 -0.9453 0.1353 6.7617 3.8253 0.9495 3.6588 0.1947 0.2375 5.7686 1.4510</span> -<span class="r-out co"><span class="r-pr">#></span> 470: 93.0769 -5.9663 -2.0715 -4.3117 -0.9452 0.1347 6.7650 3.8278 0.9503 3.6613 0.1947 0.2379 5.7688 1.4506</span> -<span class="r-out co"><span class="r-pr">#></span> 471: 93.0749 -5.9664 -2.0714 -4.3123 -0.9451 0.1342 6.7708 3.8280 0.9510 3.6643 0.1947 0.2383 5.7699 1.4505</span> -<span class="r-out co"><span class="r-pr">#></span> 472: 93.0721 -5.9668 -2.0713 -4.3127 -0.9450 0.1337 6.7756 3.8284 0.9517 3.6665 0.1947 0.2386 5.7710 1.4501</span> -<span class="r-out co"><span class="r-pr">#></span> 473: 93.0696 -5.9670 -2.0713 -4.3133 -0.9449 0.1333 6.7784 3.8280 0.9522 3.6698 0.1947 0.2388 5.7716 1.4498</span> -<span class="r-out co"><span class="r-pr">#></span> 474: 93.0674 -5.9673 -2.0714 -4.3138 -0.9448 0.1329 6.7761 3.8281 0.9527 3.6731 0.1947 0.2390 5.7729 1.4496</span> -<span class="r-out co"><span class="r-pr">#></span> 475: 93.0655 -5.9679 -2.0714 -4.3143 -0.9447 0.1324 6.7779 3.8302 0.9531 3.6762 0.1947 0.2391 5.7743 1.4493</span> -<span class="r-out co"><span class="r-pr">#></span> 476: 93.0643 -5.9682 -2.0713 -4.3144 -0.9447 0.1321 6.7776 3.8314 0.9536 3.6768 0.1946 0.2391 5.7762 1.4492</span> -<span class="r-out co"><span class="r-pr">#></span> 477: 93.0631 -5.9684 -2.0714 -4.3146 -0.9446 0.1317 6.7725 3.8326 0.9540 3.6787 0.1945 0.2392 5.7768 1.4492</span> -<span class="r-out co"><span class="r-pr">#></span> 478: 93.0630 -5.9693 -2.0715 -4.3148 -0.9447 0.1314 6.7626 3.8365 0.9543 3.6788 0.1944 0.2395 5.7785 1.4492</span> -<span class="r-out co"><span class="r-pr">#></span> 479: 93.0634 -5.9710 -2.0714 -4.3148 -0.9447 0.1310 6.7499 3.8462 0.9547 3.6778 0.1943 0.2399 5.7798 1.4490</span> -<span class="r-out co"><span class="r-pr">#></span> 480: 93.0651 -5.9732 -2.0715 -4.3147 -0.9447 0.1307 6.7463 3.8616 0.9548 3.6770 0.1943 0.2403 5.7810 1.4488</span> -<span class="r-out co"><span class="r-pr">#></span> 481: 93.0664 -5.9747 -2.0715 -4.3149 -0.9447 0.1304 6.7442 3.8722 0.9550 3.6780 0.1941 0.2409 5.7811 1.4487</span> -<span class="r-out co"><span class="r-pr">#></span> 482: 93.0647 -5.9762 -2.0714 -4.3151 -0.9447 0.1300 6.7389 3.8834 0.9554 3.6784 0.1941 0.2414 5.7816 1.4484</span> -<span class="r-out co"><span class="r-pr">#></span> 483: 93.0628 -5.9778 -2.0714 -4.3153 -0.9447 0.1295 6.7352 3.8943 0.9557 3.6783 0.1940 0.2419 5.7820 1.4483</span> -<span class="r-out co"><span class="r-pr">#></span> 484: 93.0614 -5.9787 -2.0715 -4.3153 -0.9447 0.1291 6.7314 3.8999 0.9559 3.6774 0.1939 0.2424 5.7819 1.4481</span> -<span class="r-out co"><span class="r-pr">#></span> 485: 93.0593 -5.9789 -2.0715 -4.3153 -0.9447 0.1288 6.7293 3.9007 0.9561 3.6765 0.1938 0.2430 5.7815 1.4480</span> -<span class="r-out co"><span class="r-pr">#></span> 486: 93.0575 -5.9793 -2.0716 -4.3152 -0.9447 0.1284 6.7331 3.9021 0.9563 3.6753 0.1938 0.2434 5.7806 1.4480</span> -<span class="r-out co"><span class="r-pr">#></span> 487: 93.0555 -5.9796 -2.0716 -4.3152 -0.9447 0.1281 6.7342 3.9036 0.9566 3.6741 0.1937 0.2439 5.7805 1.4479</span> -<span class="r-out co"><span class="r-pr">#></span> 488: 93.0545 -5.9795 -2.0716 -4.3152 -0.9447 0.1277 6.7365 3.9024 0.9569 3.6729 0.1937 0.2444 5.7795 1.4480</span> -<span class="r-out co"><span class="r-pr">#></span> 489: 93.0550 -5.9800 -2.0716 -4.3152 -0.9447 0.1274 6.7336 3.9046 0.9571 3.6719 0.1937 0.2448 5.7778 1.4481</span> -<span class="r-out co"><span class="r-pr">#></span> 490: 93.0571 -5.9793 -2.0715 -4.3152 -0.9447 0.1272 6.7331 3.9009 0.9573 3.6704 0.1936 0.2450 5.7767 1.4484</span> -<span class="r-out co"><span class="r-pr">#></span> 491: 93.0584 -5.9787 -2.0714 -4.3151 -0.9447 0.1270 6.7280 3.8980 0.9575 3.6688 0.1936 0.2452 5.7764 1.4487</span> -<span class="r-out co"><span class="r-pr">#></span> 492: 93.0589 -5.9786 -2.0714 -4.3150 -0.9447 0.1267 6.7264 3.8971 0.9578 3.6675 0.1936 0.2455 5.7759 1.4489</span> -<span class="r-out co"><span class="r-pr">#></span> 493: 93.0593 -5.9790 -2.0711 -4.3149 -0.9447 0.1265 6.7273 3.8982 0.9584 3.6660 0.1935 0.2456 5.7759 1.4490</span> -<span class="r-out co"><span class="r-pr">#></span> 494: 93.0594 -5.9805 -2.0710 -4.3149 -0.9448 0.1263 6.7291 3.9066 0.9590 3.6650 0.1935 0.2457 5.7758 1.4489</span> -<span class="r-out co"><span class="r-pr">#></span> 495: 93.0596 -5.9816 -2.0709 -4.3148 -0.9448 0.1261 6.7281 3.9123 0.9593 3.6639 0.1936 0.2459 5.7745 1.4490</span> -<span class="r-out co"><span class="r-pr">#></span> 496: 93.0590 -5.9829 -2.0707 -4.3148 -0.9448 0.1259 6.7319 3.9227 0.9597 3.6628 0.1936 0.2461 5.7740 1.4491</span> -<span class="r-out co"><span class="r-pr">#></span> 497: 93.0580 -5.9842 -2.0706 -4.3148 -0.9448 0.1257 6.7388 3.9326 0.9600 3.6623 0.1936 0.2463 5.7732 1.4492</span> -<span class="r-out co"><span class="r-pr">#></span> 498: 93.0578 -5.9848 -2.0705 -4.3148 -0.9448 0.1255 6.7447 3.9368 0.9605 3.6618 0.1936 0.2464 5.7726 1.4494</span> -<span class="r-out co"><span class="r-pr">#></span> 499: 93.0568 -5.9843 -2.0704 -4.3147 -0.9447 0.1253 6.7475 3.9341 0.9609 3.6612 0.1937 0.2467 5.7718 1.4495</span> -<span class="r-out co"><span class="r-pr">#></span> 500: 93.0563 -5.9831 -2.0703 -4.3147 -0.9447 0.1251 6.7500 3.9292 0.9614 3.6607 0.1937 0.2469 5.7712 1.4496</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_obs</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_obs</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis |sigma_parent | sigma_A1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 488.98943 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.98943 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.98943</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -27.68 | 2.403 | -0.1248 | -0.3242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3705 | 0.07384 | -31.92 | -15.13 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 14.74 | 13.03 | -12.01 | -2.072 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 5.553 | -10.09 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1205.4696 | 1.534 | -1.046 | -0.9091 | -0.9266 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9745 | -0.8897 | -0.2358 | -0.5780 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.162 | -1.126 | -0.6367 | -0.8323 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9817 | -0.6738 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 1205.4696 | 142.6 | -5.346 | -0.9477 | -1.994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.393 | 0.1897 | 2.616 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5160 | 0.6557 | 1.444 | 1.015 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7709 | 1.387 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1205.4696</span> | 142.6 | 0.004766 | 0.2793 | 0.1362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01237 | 0.5473 | 2.616 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5160 | 0.6557 | 1.444 | 1.015 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7709 | 1.387 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 510.70816 | 1.053 | -1.005 | -0.9113 | -0.9322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9810 | -0.8884 | -0.7899 | -0.8406 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9059 | -0.8995 | -0.8452 | -0.8683 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8853 | -0.8491 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 510.70816 | 97.96 | -5.305 | -0.9498 | -1.999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.399 | 0.1900 | 2.062 | 1.116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7005 | 0.8538 | 1.199 | 0.9804 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8541 | 1.184 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 510.70816</span> | 97.96 | 0.004969 | 0.2789 | 0.1354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01229 | 0.5474 | 2.062 | 1.116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7005 | 0.8538 | 1.199 | 0.9804 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8541 | 1.184 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 494.11470 | 1.005 | -1.000 | -0.9115 | -0.9328 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9816 | -0.8883 | -0.8453 | -0.8669 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8803 | -0.8769 | -0.8660 | -0.8719 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8757 | -0.8666 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.1147 | 93.50 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.006 | 1.102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7190 | 0.8736 | 1.175 | 0.9768 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8624 | 1.163 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.1147</span> | 93.50 | 0.004989 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.006 | 1.102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7190 | 0.8736 | 1.175 | 0.9768 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8624 | 1.163 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 494.35784 | 1.001 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8509 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8778 | -0.8746 | -0.8681 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8747 | -0.8683 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.35784 | 93.05 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.001 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7208 | 0.8755 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8632 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.35784</span> | 93.05 | 0.004991 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.001 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7208 | 0.8755 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8632 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 494.40319 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8514 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8744 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40319 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8757 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40319</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8757 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 494.40793 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8744 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40793 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40793</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 494.40830 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.4083 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.4083</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 494.40832 | 1.000 | -1.000 | -0.9115 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9817 | -0.8883 | -0.8515 | -0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8775 | -0.8743 | -0.8683 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8746 | -0.8685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.40832 | 93.00 | -5.300 | -0.9500 | -2.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.400 | 0.1900 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.40832</span> | 93.00 | 0.004992 | 0.2789 | 0.1353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01228 | 0.5474 | 2.000 | 1.100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7210 | 0.8758 | 1.172 | 0.9765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># Identical two-component error for all variables is only possible with</span></span> -<span class="r-in"><span class="co"># est = 'focei' in nlmixr</span></span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta | sigma_low | rsd_high | o1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o2 | o3 | o4 | o5 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 500.20030 | 1.000 | -1.000 | -0.9113 | -0.8944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8678 | -0.8916 | -0.8767 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8743 | -0.8675 | -0.8704 | -0.8704 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 500.2003 | 93.00 | -5.300 | -0.9400 | -0.1100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.200 | 0.03000 | 0.7598 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.214 | 1.068 | 1.071 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 500.2003</span> | 93.00 | 0.004992 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.200 | 0.03000 | 0.7598 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8758 | 1.214 | 1.068 | 1.071 |</span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 48.88 | 2.383 | 0.1231 | 0.1986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1571 | -64.31 | -21.89 | 0.6250 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.41 | -12.48 | -9.903 | -10.91 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2909.4393 | 0.4361 | -1.027 | -0.9127 | -0.8967 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8472 | -0.1258 | -0.6390 | -0.8839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.7235 | -0.7562 | -0.7445 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 2909.4393 | 40.56 | -5.327 | -0.9413 | -0.1123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.645 | 0.03379 | 0.7544 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7605 | 1.389 | 1.189 | 1.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2909.4393</span> | 40.56 | 0.004856 | 0.2806 | 0.8938 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.956 | 1.645 | 0.03379 | 0.7544 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7605 | 1.389 | 1.189 | 1.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 515.24373 | 0.9436 | -1.003 | -0.9114 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7936 | -0.8663 | -0.8774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8875 | -0.8531 | -0.8590 | -0.8578 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 515.24373 | 87.76 | -5.303 | -0.9401 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.245 | 0.03038 | 0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8642 | 1.232 | 1.080 | 1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 515.24373</span> | 87.76 | 0.004978 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.245 | 0.03038 | 0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8642 | 1.232 | 1.080 | 1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 499.40695 | 0.9897 | -1.001 | -0.9113 | -0.8944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8542 | -0.8869 | -0.8768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8768 | -0.8648 | -0.8684 | -0.8681 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 499.40695 | 92.04 | -5.301 | -0.9400 | -0.1100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.208 | 0.03007 | 0.7597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8737 | 1.217 | 1.070 | 1.073 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 499.40695</span> | 92.04 | 0.004989 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.208 | 0.03007 | 0.7597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8737 | 1.217 | 1.070 | 1.073 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -99.71 | 2.245 | -0.1707 | 0.1202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1546 | -61.69 | -22.54 | 1.475 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.677 | -11.72 | -9.584 | -10.53 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 498.17135 | 1.001 | -1.001 | -0.9113 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8410 | -0.8822 | -0.8771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8786 | -0.8623 | -0.8663 | -0.8658 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 498.17135 | 93.06 | -5.301 | -0.9400 | -0.1101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.216 | 0.03014 | 0.7595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8720 | 1.221 | 1.072 | 1.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 498.17135</span> | 93.06 | 0.004987 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.216 | 0.03014 | 0.7595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8720 | 1.221 | 1.072 | 1.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.25 | 2.349 | 0.1359 | 0.2180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1993 | -60.48 | -20.28 | 1.106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.662 | -11.74 | -9.501 | -10.55 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 497.33758 | 0.9906 | -1.002 | -0.9113 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8273 | -0.8776 | -0.8773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8808 | -0.8596 | -0.8642 | -0.8634 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 497.33758 | 92.12 | -5.302 | -0.9400 | -0.1101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.224 | 0.03021 | 0.7594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8701 | 1.224 | 1.074 | 1.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 497.33758</span> | 92.12 | 0.004984 | 0.2809 | 0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.224 | 0.03021 | 0.7594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8701 | 1.224 | 1.074 | 1.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -88.13 | 2.220 | -0.1371 | 0.1382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1101 | -57.44 | -20.90 | 1.111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.358 | -11.52 | -9.371 | -10.34 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 496.20963 | 1.001 | -1.002 | -0.9113 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8137 | -0.8728 | -0.8776 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8827 | -0.8569 | -0.8620 | -0.8610 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 496.20963 | 93.07 | -5.302 | -0.9400 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.232 | 0.03028 | 0.7592 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8684 | 1.227 | 1.077 | 1.081 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.20963</span> | 93.07 | 0.004981 | 0.2809 | 0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.232 | 0.03028 | 0.7592 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8684 | 1.227 | 1.077 | 1.081 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.31 | 2.316 | 0.1573 | 0.2363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2327 | -56.27 | -18.79 | 0.9054 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.277 | -11.53 | -9.283 | -10.35 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 495.35926 | 0.9914 | -1.003 | -0.9113 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7996 | -0.8680 | -0.8778 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8850 | -0.8541 | -0.8597 | -0.8584 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.35926 | 92.20 | -5.303 | -0.9401 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.241 | 0.03035 | 0.7590 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8664 | 1.231 | 1.079 | 1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.35926</span> | 92.20 | 0.004979 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.241 | 0.03035 | 0.7590 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8664 | 1.231 | 1.079 | 1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -77.78 | 2.194 | -0.1077 | 0.1552 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06714 | -52.97 | -19.27 | 0.8916 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.037 | -11.29 | -9.130 | -10.15 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 494.33654 | 1.001 | -1.003 | -0.9113 | -0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7857 | -0.8631 | -0.8780 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8870 | -0.8511 | -0.8573 | -0.8558 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.33654 | 93.09 | -5.303 | -0.9400 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.249 | 0.03043 | 0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8647 | 1.234 | 1.082 | 1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.33654</span> | 93.09 | 0.004976 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.249 | 0.03043 | 0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8647 | 1.234 | 1.082 | 1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.95 | 2.282 | 0.1850 | 0.2507 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2656 | -51.81 | -17.28 | 0.8212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.543 | -11.27 | -9.029 | -10.13 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 493.47922 | 0.9922 | -1.004 | -0.9114 | -0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7714 | -0.8582 | -0.8782 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8891 | -0.8480 | -0.8548 | -0.8530 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 493.47922 | 92.28 | -5.304 | -0.9401 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.258 | 0.03050 | 0.7587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8629 | 1.238 | 1.084 | 1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.47922</span> | 92.28 | 0.004973 | 0.2809 | 0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.258 | 0.03050 | 0.7587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8629 | 1.238 | 1.084 | 1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -67.18 | 2.173 | -0.07166 | 0.1818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01313 | -49.19 | -17.69 | 0.7047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.114 | -11.03 | -8.882 | -9.923 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 492.53845 | 1.001 | -1.004 | -0.9114 | -0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7572 | -0.8532 | -0.8784 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8914 | -0.8448 | -0.8522 | -0.8501 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 492.53845 | 93.09 | -5.304 | -0.9401 | -0.1104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.266 | 0.03057 | 0.7585 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8608 | 1.242 | 1.087 | 1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.53845</span> | 93.09 | 0.004969 | 0.2809 | 0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.266 | 0.03057 | 0.7585 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8608 | 1.242 | 1.087 | 1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 53.38 | 2.243 | 0.1941 | 0.2566 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2879 | -47.96 | -15.83 | 0.7595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.537 | -10.98 | -8.771 | -9.890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 491.72645 | 0.9926 | -1.005 | -0.9114 | -0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8456 | -0.7429 | -0.8484 | -0.8786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8941 | -0.8415 | -0.8496 | -0.8471 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.72645 | 92.31 | -5.305 | -0.9401 | -0.1105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.275 | 0.03065 | 0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8584 | 1.246 | 1.090 | 1.096 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.72645</span> | 92.31 | 0.004966 | 0.2809 | 0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.275 | 0.03065 | 0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8584 | 1.246 | 1.090 | 1.096 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -63.56 | 2.131 | -0.05387 | 0.1833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.0009134 | -45.55 | -16.30 | 0.3872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.447 | -10.76 | -8.612 | -9.684 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 490.83850 | 1.001 | -1.006 | -0.9114 | -0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8457 | -0.7286 | -0.8435 | -0.8787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -0.8380 | -0.8468 | -0.8440 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.8385 | 93.07 | -5.306 | -0.9401 | -0.1105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.283 | 0.03072 | 0.7583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8556 | 1.250 | 1.093 | 1.099 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.8385</span> | 93.07 | 0.004963 | 0.2809 | 0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.971 | 1.283 | 0.03072 | 0.7583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8556 | 1.250 | 1.093 | 1.099 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.01 | 2.198 | 0.2057 | 0.2666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3102 | -44.06 | -14.52 | 0.5614 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.039 | -10.72 | -8.482 | -9.628 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 490.09324 | 0.9928 | -1.007 | -0.9115 | -0.8950 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8458 | -0.7143 | -0.8387 | -0.8788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.8343 | -0.8439 | -0.8407 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.09324 | 92.33 | -5.307 | -0.9402 | -0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.292 | 0.03079 | 0.7582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8529 | 1.254 | 1.096 | 1.103 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.09324</span> | 92.33 | 0.004959 | 0.2809 | 0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.970 | 1.292 | 0.03079 | 0.7582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8529 | 1.254 | 1.096 | 1.103 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -62.13 | 2.095 | -0.03472 | 0.1999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03562 | -41.55 | -14.84 | 0.5236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.264 | -10.46 | -8.310 | -9.412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 489.25271 | 1.001 | -1.007 | -0.9115 | -0.8951 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8458 | -0.7001 | -0.8338 | -0.8789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | -0.8304 | -0.8408 | -0.8372 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 489.25271 | 93.06 | -5.307 | -0.9402 | -0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.301 | 0.03087 | 0.7581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8505 | 1.259 | 1.099 | 1.107 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.25271</span> | 93.06 | 0.004955 | 0.2809 | 0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.970 | 1.301 | 0.03087 | 0.7581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8505 | 1.259 | 1.099 | 1.107 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 44.98 | 2.155 | 0.2191 | 0.2769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3339 | -40.42 | -13.24 | 0.4473 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.595 | -10.35 | -8.165 | -9.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 488.54089 | 0.9934 | -1.008 | -0.9116 | -0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8459 | -0.6857 | -0.8290 | -0.8790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9061 | -0.8262 | -0.8376 | -0.8335 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.54089 | 92.38 | -5.308 | -0.9403 | -0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.309 | 0.03094 | 0.7581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8479 | 1.264 | 1.103 | 1.111 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.54089</span> | 92.38 | 0.004951 | 0.2808 | 0.8951 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.968 | 1.309 | 0.03094 | 0.7581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8479 | 1.264 | 1.103 | 1.111 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -55.81 | 2.061 | -0.02096 | 0.2050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07367 | -38.08 | -13.50 | 0.4111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.904 | -10.08 | -7.981 | -9.106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 487.77387 | 1.001 | -1.009 | -0.9116 | -0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8461 | -0.6716 | -0.8243 | -0.8791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9092 | -0.8218 | -0.8341 | -0.8294 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.77387 | 93.07 | -5.309 | -0.9403 | -0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.318 | 0.03101 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 1.270 | 1.106 | 1.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.77387</span> | 93.07 | 0.004946 | 0.2808 | 0.8950 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.967 | 1.318 | 0.03101 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 1.270 | 1.106 | 1.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 43.45 | 2.114 | 0.2402 | 0.2940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | -36.87 | -12.03 | 0.3081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.143 | -10.02 | -7.799 | -9.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 487.09815 | 0.9939 | -1.010 | -0.9118 | -0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8463 | -0.6575 | -0.8197 | -0.8791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9124 | -0.8169 | -0.8304 | -0.8251 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.09815 | 92.43 | -5.310 | -0.9404 | -0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.326 | 0.03108 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8425 | 1.276 | 1.110 | 1.120 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.09815</span> | 92.43 | 0.004941 | 0.2808 | 0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.965 | 1.326 | 0.03108 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8425 | 1.276 | 1.110 | 1.120 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.03 | 2.024 | 0.005993 | 0.2193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1119 | -34.69 | -12.26 | 0.2072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.453 | -9.722 | -7.597 | -8.758 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 486.39882 | 1.001 | -1.011 | -0.9119 | -0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8465 | -0.6438 | -0.8151 | -0.8789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9156 | -0.8116 | -0.8264 | -0.8203 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 486.39882 | 93.07 | -5.311 | -0.9405 | -0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.334 | 0.03115 | 0.7582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8396 | 1.282 | 1.114 | 1.125 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.39882</span> | 93.07 | 0.004935 | 0.2808 | 0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.963 | 1.334 | 0.03115 | 0.7582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8396 | 1.282 | 1.114 | 1.125 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.24 | 2.069 | 0.2581 | 0.3038 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3965 | -33.71 | -10.93 | 0.1523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.279 | -9.597 | -7.397 | -8.617 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 485.77269 | 0.9943 | -1.013 | -0.9120 | -0.8959 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8467 | -0.6301 | -0.8107 | -0.8786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9175 | -0.8058 | -0.8222 | -0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.77269 | 92.47 | -5.313 | -0.9407 | -0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.299 | 1.343 | 0.03121 | 0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 1.289 | 1.119 | 1.130 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.77269</span> | 92.47 | 0.004928 | 0.2808 | 0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.960 | 1.343 | 0.03121 | 0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 1.289 | 1.119 | 1.130 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -45.38 | 1.992 | 0.03513 | 0.2356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1513 | -31.62 | -11.12 | 0.08802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.113 | -9.278 | -7.167 | -8.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 485.13787 | 1.001 | -1.014 | -0.9122 | -0.8962 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.6169 | -0.8065 | -0.8780 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9196 | -0.7993 | -0.8176 | -0.8094 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.13787 | 93.06 | -5.314 | -0.9409 | -0.1118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.351 | 0.03128 | 0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8361 | 1.297 | 1.124 | 1.136 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.13787</span> | 93.06 | 0.004921 | 0.2807 | 0.8942 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.957 | 1.351 | 0.03128 | 0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8361 | 1.297 | 1.124 | 1.136 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 37.95 | 2.033 | 0.2726 | 0.3147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4223 | -30.68 | -9.906 | 0.05100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.975 | -9.039 | -6.928 | -8.144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 484.56781 | 0.9947 | -1.016 | -0.9125 | -0.8965 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8476 | -0.6040 | -0.8026 | -0.8774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9219 | -0.7925 | -0.8127 | -0.8032 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.56781 | 92.51 | -5.316 | -0.9411 | -0.1121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.358 | 0.03133 | 0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 1.305 | 1.129 | 1.143 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.56781</span> | 92.51 | 0.004912 | 0.2807 | 0.8939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.952 | 1.358 | 0.03133 | 0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 1.305 | 1.129 | 1.143 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -42.28 | 1.959 | 0.05438 | 0.2483 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1829 | -28.95 | -10.12 | -0.04344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.379 | -8.677 | -6.653 | -7.817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 484.00832 | 1.000 | -1.018 | -0.9128 | -0.8970 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8481 | -0.5915 | -0.7988 | -0.8764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9214 | -0.7852 | -0.8076 | -0.7966 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.00832 | 93.05 | -5.318 | -0.9414 | -0.1125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.297 | 1.366 | 0.03139 | 0.7601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 1.314 | 1.135 | 1.150 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.00832</span> | 93.05 | 0.004901 | 0.2806 | 0.8936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.947 | 1.366 | 0.03139 | 0.7601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 1.314 | 1.135 | 1.150 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.54 | 2.001 | 0.2786 | 0.3182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4381 | -28.02 | -9.026 | -0.09975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 6.146 | -8.496 | -6.417 | -7.602 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 483.48726 | 0.9952 | -1.021 | -0.9132 | -0.8975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8489 | -0.5798 | -0.7955 | -0.8750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9256 | -0.7775 | -0.8025 | -0.7898 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.48726 | 92.55 | -5.321 | -0.9418 | -0.1131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.296 | 1.373 | 0.03144 | 0.7611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8309 | 1.323 | 1.140 | 1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.48726</span> | 92.55 | 0.004889 | 0.2805 | 0.8931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.939 | 1.373 | 0.03144 | 0.7611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8309 | 1.323 | 1.140 | 1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -37.52 | 1.926 | 0.07054 | 0.2526 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2102 | -26.43 | -9.184 | -0.1123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.591 | -8.057 | -6.119 | -7.239 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 482.99669 | 1.001 | -1.023 | -0.9136 | -0.8980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8497 | -0.5700 | -0.7928 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9342 | -0.7702 | -0.7978 | -0.7834 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.99669 | 93.05 | -5.323 | -0.9422 | -0.1136 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.296 | 1.379 | 0.03148 | 0.7623 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 1.332 | 1.145 | 1.164 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.99669</span> | 93.05 | 0.004876 | 0.2805 | 0.8926 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.932 | 1.379 | 0.03148 | 0.7623 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 1.332 | 1.145 | 1.164 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 33.56 | 1.934 | 0.3091 | 0.3219 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4700 | -25.85 | -8.255 | -0.09267 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.467 | -7.833 | -5.883 | -7.031 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 482.53338 | 0.9957 | -1.027 | -0.9143 | -0.8987 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8507 | -0.5600 | -0.7904 | -0.8719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9423 | -0.7626 | -0.7931 | -0.7767 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.53338 | 92.60 | -5.327 | -0.9428 | -0.1143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.295 | 1.385 | 0.03152 | 0.7635 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8163 | 1.342 | 1.150 | 1.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.53338</span> | 92.60 | 0.004861 | 0.2803 | 0.8920 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.921 | 1.385 | 0.03152 | 0.7635 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8163 | 1.342 | 1.150 | 1.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.71 | 1.852 | 0.1405 | 0.2615 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2476 | -24.53 | -8.462 | -0.2274 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.657 | -7.455 | -5.599 | -6.689 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 482.07760 | 1.001 | -1.030 | -0.9154 | -0.8996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8522 | -0.5495 | -0.7881 | -0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9481 | -0.7546 | -0.7885 | -0.7696 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.0776 | 93.06 | -5.330 | -0.9439 | -0.1152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.293 | 1.391 | 0.03155 | 0.7654 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8112 | 1.351 | 1.155 | 1.179 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.0776</span> | 93.06 | 0.004842 | 0.2801 | 0.8912 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.906 | 1.391 | 0.03155 | 0.7654 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8112 | 1.351 | 1.155 | 1.179 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 31.51 | 1.862 | 0.3171 | 0.3253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4890 | -23.74 | -7.570 | -0.1627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.673 | -7.176 | -5.365 | -6.441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 481.65018 | 0.9960 | -1.035 | -0.9168 | -0.9007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8541 | -0.5386 | -0.7859 | -0.8662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9515 | -0.7465 | -0.7840 | -0.7624 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.65018 | 92.63 | -5.335 | -0.9452 | -0.1163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | 1.398 | 0.03158 | 0.7678 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8082 | 1.361 | 1.160 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.65018</span> | 92.63 | 0.004820 | 0.2799 | 0.8902 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.887 | 1.398 | 0.03158 | 0.7678 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8082 | 1.361 | 1.160 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.18 | 1.794 | 0.1244 | 0.2518 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2479 | -22.54 | -7.736 | -0.2537 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.155 | -6.794 | -5.094 | -6.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 481.23911 | 1.000 | -1.041 | -0.9182 | -0.9020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8564 | -0.5274 | -0.7840 | -0.8624 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9539 | -0.7386 | -0.7800 | -0.7556 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.23911 | 93.04 | -5.341 | -0.9465 | -0.1176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.289 | 1.404 | 0.03161 | 0.7707 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8061 | 1.371 | 1.164 | 1.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.23911</span> | 93.04 | 0.004792 | 0.2796 | 0.8890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.865 | 1.404 | 0.03161 | 0.7707 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8061 | 1.371 | 1.164 | 1.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 480.84332 | 1.001 | -1.048 | -0.9201 | -0.9037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8593 | -0.5164 | -0.7829 | -0.8573 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.7293 | -0.7754 | -0.7475 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.84332 | 93.06 | -5.348 | -0.9483 | -0.1193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.286 | 1.411 | 0.03163 | 0.7746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8041 | 1.382 | 1.169 | 1.203 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.84332</span> | 93.06 | 0.004757 | 0.2792 | 0.8875 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.836 | 1.411 | 0.03163 | 0.7746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8041 | 1.382 | 1.169 | 1.203 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 479.47395 | 1.001 | -1.077 | -0.9274 | -0.9105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8708 | -0.4737 | -0.7785 | -0.8375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9655 | -0.6927 | -0.7575 | -0.7158 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.47395 | 93.12 | -5.377 | -0.9551 | -0.1261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.275 | 1.436 | 0.03170 | 0.7896 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7959 | 1.426 | 1.188 | 1.237 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.47395</span> | 93.12 | 0.004620 | 0.2779 | 0.8816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.723 | 1.436 | 0.03170 | 0.7896 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7959 | 1.426 | 1.188 | 1.237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 477.01144 | 1.003 | -1.162 | -0.9485 | -0.9300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9044 | -0.3493 | -0.7656 | -0.7799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9925 | -0.5865 | -0.7057 | -0.6237 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.01144 | 93.31 | -5.462 | -0.9750 | -0.1456 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.241 | 1.511 | 0.03189 | 0.8334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7723 | 1.555 | 1.243 | 1.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.01144</span> | 93.31 | 0.004245 | 0.2739 | 0.8645 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.403 | 1.511 | 0.03189 | 0.8334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7723 | 1.555 | 1.243 | 1.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.38 | 1.353 | -0.3553 | -0.05530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.006768 | -8.661 | -2.325 | -0.1540 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.503 | -0.2811 | -0.6438 | -0.5229 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 477.99463 | 1.002 | -1.284 | -0.8933 | -0.9162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8846 | -0.1951 | -0.7385 | -0.7367 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.093 | -0.7697 | -0.8046 | -0.7596 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.99463 | 93.20 | -5.584 | -0.9231 | -0.1318 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.261 | 1.604 | 0.03230 | 0.8662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6840 | 1.333 | 1.138 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.99463</span> | 93.20 | 0.003757 | 0.2843 | 0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.591 | 1.604 | 0.03230 | 0.8662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6840 | 1.333 | 1.138 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 476.67952 | 1.000 | -1.201 | -0.9310 | -0.9256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.3000 | -0.7569 | -0.7662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.6445 | -0.7370 | -0.6668 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.67952 | 93.04 | -5.501 | -0.9585 | -0.1412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.541 | 0.03202 | 0.8438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7442 | 1.485 | 1.210 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.67952</span> | 93.04 | 0.004084 | 0.2772 | 0.8683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.541 | 0.03202 | 0.8438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7442 | 1.485 | 1.210 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.308 | 1.138 | 0.3206 | 0.007327 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.005220 | -6.420 | -1.952 | -0.8085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4295 | -3.531 | -2.349 | -2.485 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 477.00015 | 0.9939 | -1.268 | -0.9234 | -0.9152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8823 | -0.2647 | -0.7585 | -0.7168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9725 | -0.6365 | -0.7310 | -0.6853 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.00015 | 92.43 | -5.568 | -0.9514 | -0.1308 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.263 | 1.562 | 0.03200 | 0.8813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 1.495 | 1.216 | 1.269 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.00015</span> | 92.43 | 0.003818 | 0.2786 | 0.8774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.613 | 1.562 | 0.03200 | 0.8813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 1.495 | 1.216 | 1.269 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 476.87328 | 0.9941 | -1.216 | -0.9300 | -0.9236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8950 | -0.2832 | -0.7542 | -0.7554 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -0.6375 | -0.7322 | -0.6666 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.87328 | 92.45 | -5.516 | -0.9576 | -0.1392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.551 | 0.03206 | 0.8520 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7536 | 1.493 | 1.215 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.87328</span> | 92.45 | 0.004024 | 0.2774 | 0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.491 | 1.551 | 0.03206 | 0.8520 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7536 | 1.493 | 1.215 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 476.68202 | 0.9977 | -1.202 | -0.9313 | -0.9256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.2947 | -0.7553 | -0.7655 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6416 | -0.7351 | -0.6648 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.68202 | 92.79 | -5.502 | -0.9588 | -0.1412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.544 | 0.03204 | 0.8443 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7445 | 1.488 | 1.212 | 1.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.68202</span> | 92.79 | 0.004080 | 0.2771 | 0.8683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.544 | 0.03204 | 0.8443 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7445 | 1.488 | 1.212 | 1.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 476.66620 | 0.9991 | -1.201 | -0.9311 | -0.9256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8981 | -0.2974 | -0.7561 | -0.7659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6431 | -0.7361 | -0.6658 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.6662 | 92.92 | -5.501 | -0.9587 | -0.1412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.542 | 0.03203 | 0.8441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7443 | 1.487 | 1.211 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.6662</span> | 92.92 | 0.004082 | 0.2771 | 0.8683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.462 | 1.542 | 0.03203 | 0.8441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7443 | 1.487 | 1.211 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.67 | 1.127 | 0.2138 | -0.01630 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1134 | -4.869 | -1.703 | -0.03057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03000 | -2.848 | -2.302 | -2.432 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 476.65034 | 1.001 | -1.204 | -0.9308 | -0.9253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -0.2967 | -0.7561 | -0.7660 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6432 | -0.7350 | -0.6655 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.65034 | 93.06 | -5.504 | -0.9584 | -0.1409 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.248 | 1.543 | 0.03203 | 0.8440 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7448 | 1.487 | 1.212 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.65034</span> | 93.06 | 0.004070 | 0.2772 | 0.8686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.468 | 1.543 | 0.03203 | 0.8440 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7448 | 1.487 | 1.212 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.111 | 1.131 | 0.3498 | 0.02199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03596 | -6.336 | -1.893 | -0.8646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4089 | -3.511 | -2.253 | -2.437 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 476.63921 | 0.9998 | -1.207 | -0.9306 | -0.9249 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8968 | -0.2957 | -0.7561 | -0.7661 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6430 | -0.7338 | -0.6650 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.63921 | 92.98 | -5.507 | -0.9581 | -0.1405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.543 | 0.03203 | 0.8439 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.487 | 1.213 | 1.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.63921</span> | 92.98 | 0.004058 | 0.2773 | 0.8689 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.474 | 1.543 | 0.03203 | 0.8439 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.487 | 1.213 | 1.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.837 | 1.116 | 0.2875 | 0.01149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02542 | -4.741 | -1.572 | 0.01643 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.427 | -2.805 | -2.162 | -2.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 476.63321 | 1.001 | -1.209 | -0.9304 | -0.9247 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8965 | -0.2943 | -0.7557 | -0.7669 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.6432 | -0.7330 | -0.6644 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.63321 | 93.07 | -5.509 | -0.9580 | -0.1403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.544 | 0.03204 | 0.8433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7468 | 1.487 | 1.214 | 1.292 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.63321</span> | 93.07 | 0.004050 | 0.2773 | 0.8691 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.477 | 1.544 | 0.03204 | 0.8433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7468 | 1.487 | 1.214 | 1.292 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.780 | 1.119 | 0.3715 | 0.03544 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06786 | -4.773 | -1.470 | -0.02124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.265 | -2.850 | -2.132 | -2.390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 476.62737 | 0.9998 | -1.211 | -0.9303 | -0.9246 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8963 | -0.2932 | -0.7554 | -0.7683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.6436 | -0.7322 | -0.6637 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.62737 | 92.98 | -5.511 | -0.9578 | -0.1402 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.545 | 0.03204 | 0.8422 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.486 | 1.215 | 1.292 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.62737</span> | 92.98 | 0.004043 | 0.2773 | 0.8692 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.479 | 1.545 | 0.03204 | 0.8422 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.486 | 1.215 | 1.292 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.468 | 1.108 | 0.2964 | 0.01787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.01029 | -4.584 | -1.512 | -0.04750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.233 | -2.839 | -2.097 | -2.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 476.62183 | 1.001 | -1.213 | -0.9301 | -0.9245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8960 | -0.2918 | -0.7549 | -0.7696 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -0.6438 | -0.7313 | -0.6628 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.62183 | 93.07 | -5.513 | -0.9577 | -0.1401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.546 | 0.03205 | 0.8412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 1.486 | 1.216 | 1.293 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.62183</span> | 93.07 | 0.004035 | 0.2773 | 0.8693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.481 | 1.546 | 0.03205 | 0.8412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7501 | 1.486 | 1.216 | 1.293 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.726 | 1.111 | 0.3721 | 0.03969 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07339 | -4.588 | -1.391 | -0.04583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.059 | -2.851 | -2.052 | -2.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 476.61645 | 0.9998 | -1.215 | -0.9300 | -0.9243 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8958 | -0.2908 | -0.7546 | -0.7711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -0.6442 | -0.7306 | -0.6621 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.61645 | 92.98 | -5.515 | -0.9576 | -0.1399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.546 | 0.03205 | 0.8401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7517 | 1.485 | 1.217 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.61645</span> | 92.98 | 0.004027 | 0.2774 | 0.8694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.484 | 1.546 | 0.03205 | 0.8401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7517 | 1.485 | 1.217 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.224 | 1.099 | 0.2980 | 0.02349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.002638 | -4.438 | -1.447 | -0.09166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4490 | -2.896 | -2.021 | -2.267 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 476.60491 | 1.001 | -1.217 | -0.9300 | -0.9242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8956 | -0.2899 | -0.7543 | -0.7729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -0.6437 | -0.7294 | -0.6608 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.60491 | 93.08 | -5.517 | -0.9576 | -0.1398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 1.486 | 1.218 | 1.295 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.60491</span> | 93.08 | 0.004018 | 0.2774 | 0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.485 | 1.547 | 0.03206 | 0.8387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7514 | 1.486 | 1.218 | 1.295 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.891 | 1.101 | 0.3805 | 0.04781 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09121 | -4.602 | -1.355 | -0.1211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9908 | -2.875 | -1.954 | -2.212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 476.59275 | 0.9999 | -1.219 | -0.9301 | -0.9241 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8954 | -0.2896 | -0.7542 | -0.7748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.6434 | -0.7284 | -0.6597 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.59275 | 92.99 | -5.519 | -0.9576 | -0.1397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7512 | 1.486 | 1.219 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.59275</span> | 92.99 | 0.004009 | 0.2774 | 0.8696 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.487 | 1.547 | 0.03206 | 0.8373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7512 | 1.486 | 1.219 | 1.297 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.741 | 1.086 | 0.3018 | 0.02978 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01334 | -4.300 | -1.393 | -0.08082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4335 | -2.821 | -1.884 | -2.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 476.58049 | 1.001 | -1.222 | -0.9302 | -0.9241 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8953 | -0.2889 | -0.7541 | -0.7767 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -0.6427 | -0.7275 | -0.6585 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.58049 | 93.06 | -5.522 | -0.9577 | -0.1397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7507 | 1.487 | 1.220 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.58049</span> | 93.06 | 0.003999 | 0.2773 | 0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.488 | 1.547 | 0.03206 | 0.8359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7507 | 1.487 | 1.220 | 1.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 476.57085 | 1.001 | -1.225 | -0.9302 | -0.9239 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8951 | -0.2891 | -0.7542 | -0.7796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -0.6424 | -0.7265 | -0.6573 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.57085 | 93.06 | -5.525 | -0.9578 | -0.1395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.250 | 1.547 | 0.03206 | 0.8336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7502 | 1.488 | 1.221 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.57085</span> | 93.06 | 0.003985 | 0.2773 | 0.8698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.490 | 1.547 | 0.03206 | 0.8336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7502 | 1.488 | 1.221 | 1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 476.52700 | 1.000 | -1.243 | -0.9306 | -0.9233 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.2898 | -0.7549 | -0.7948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.6409 | -0.7216 | -0.6509 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.527 | 93.02 | -5.543 | -0.9582 | -0.1389 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.251 | 1.547 | 0.03205 | 0.8221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7475 | 1.489 | 1.226 | 1.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.527</span> | 93.02 | 0.003915 | 0.2772 | 0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.501 | 1.547 | 0.03205 | 0.8221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7475 | 1.489 | 1.226 | 1.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 476.45166 | 0.9988 | -1.314 | -0.9321 | -0.9209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8895 | -0.2927 | -0.7576 | -0.8554 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.033 | -0.6351 | -0.7022 | -0.6254 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.45166 | 92.89 | -5.614 | -0.9596 | -0.1365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.256 | 1.545 | 0.03201 | 0.7760 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7365 | 1.496 | 1.247 | 1.333 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.45166</span> | 92.89 | 0.003648 | 0.2770 | 0.8724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.543 | 1.545 | 0.03201 | 0.7760 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7365 | 1.496 | 1.247 | 1.333 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -21.31 | 0.8191 | 0.2022 | 0.1018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1327 | -4.505 | -1.303 | -1.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.080 | -2.304 | -0.3706 | -0.4948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 476.56836 | 1.004 | -1.424 | -0.9336 | -0.9183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8856 | -0.2810 | -0.7637 | -0.9206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.6303 | -0.6962 | -0.6148 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.56836 | 93.36 | -5.724 | -0.9609 | -0.1338 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.260 | 1.552 | 0.03192 | 0.7265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 1.502 | 1.254 | 1.345 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.56836</span> | 93.36 | 0.003266 | 0.2767 | 0.8747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.581 | 1.552 | 0.03192 | 0.7265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7619 | 1.502 | 1.254 | 1.345 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 476.44457 | 1.002 | -1.351 | -0.9326 | -0.9200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8882 | -0.2885 | -0.7595 | -0.8773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6333 | -0.7001 | -0.6218 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.44457 | 93.15 | -5.651 | -0.9600 | -0.1356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.257 | 1.548 | 0.03198 | 0.7594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.499 | 1.249 | 1.337 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.44457</span> | 93.15 | 0.003514 | 0.2769 | 0.8732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.556 | 1.548 | 0.03198 | 0.7594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7451 | 1.499 | 1.249 | 1.337 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.82 | 0.7276 | 0.3571 | 0.1746 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4004 | -4.436 | -0.9222 | -1.572 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.287 | -2.164 | -0.2873 | -0.3883 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 476.40417 | 1.000 | -1.371 | -0.9349 | -0.9209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8904 | -0.2869 | -0.7634 | -0.8782 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.6262 | -0.7046 | -0.6250 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.40417 | 93.02 | -5.671 | -0.9622 | -0.1365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.255 | 1.549 | 0.03192 | 0.7587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7444 | 1.507 | 1.245 | 1.334 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.40417</span> | 93.02 | 0.003446 | 0.2764 | 0.8724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.535 | 1.549 | 0.03192 | 0.7587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7444 | 1.507 | 1.245 | 1.334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 476.37918 | 1.000 | -1.391 | -0.9372 | -0.9218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8927 | -0.2856 | -0.7675 | -0.8792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.6191 | -0.7092 | -0.6283 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.37918 | 93.03 | -5.691 | -0.9644 | -0.1374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.253 | 1.549 | 0.03186 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7434 | 1.516 | 1.240 | 1.330 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.37918</span> | 93.03 | 0.003376 | 0.2760 | 0.8716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.513 | 1.549 | 0.03186 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7434 | 1.516 | 1.240 | 1.330 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 476.33357 | 1.001 | -1.461 | -0.9453 | -0.9249 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.2814 | -0.7818 | -0.8827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.5944 | -0.7253 | -0.6399 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.33357 | 93.07 | -5.761 | -0.9719 | -0.1405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.245 | 1.552 | 0.03165 | 0.7553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7403 | 1.546 | 1.222 | 1.318 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.33357</span> | 93.07 | 0.003146 | 0.2745 | 0.8689 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.440 | 1.552 | 0.03165 | 0.7553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7403 | 1.546 | 1.222 | 1.318 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.553 | 0.4475 | -0.2195 | 0.07220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05655 | -4.350 | -1.061 | -1.750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1436 | -0.4527 | -1.673 | -1.245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 476.20746 | 1.002 | -1.571 | -0.9452 | -0.9313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9123 | -0.2680 | -0.8139 | -0.8382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.032 | -0.6009 | -0.7081 | -0.6381 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.20746 | 93.20 | -5.871 | -0.9719 | -0.1469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.233 | 1.560 | 0.03117 | 0.7891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7373 | 1.538 | 1.241 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.20746</span> | 93.20 | 0.002821 | 0.2745 | 0.8634 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.328 | 1.560 | 0.03117 | 0.7891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7373 | 1.538 | 1.241 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.15 | 0.1791 | -0.01894 | -0.004675 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06593 | -5.850 | -1.512 | -1.794 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.396 | -1.647 | -0.7085 | -1.309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 476.15444 | 1.000 | -1.669 | -0.9317 | -0.9229 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | -0.2480 | -0.8424 | -0.7961 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.6117 | -0.7275 | -0.5959 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.15444 | 93.03 | -5.969 | -0.9591 | -0.1385 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.256 | 1.572 | 0.03074 | 0.8211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.525 | 1.220 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.15444</span> | 93.03 | 0.002558 | 0.2771 | 0.8707 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.549 | 1.572 | 0.03074 | 0.8211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7395 | 1.525 | 1.220 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.97 | -0.09883 | 0.5245 | 0.1410 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5845 | -3.407 | -1.272 | -0.2800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9652 | -1.487 | -1.684 | 0.3572 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 476.18235 | 1.000 | -1.690 | -0.9781 | -0.8961 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8818 | -0.1915 | -0.8548 | -0.7635 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.6068 | -0.6702 | -0.6625 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.18235 | 93.04 | -5.990 | -1.003 | -0.1117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.264 | 1.606 | 0.03055 | 0.8458 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.531 | 1.281 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.18235</span> | 93.04 | 0.002505 | 0.2684 | 0.8943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.617 | 1.606 | 0.03055 | 0.8458 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.531 | 1.281 | 1.294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 476.08231 | 1.003 | -1.678 | -0.9530 | -0.9107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8858 | -0.2215 | -0.8479 | -0.7811 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -0.6092 | -0.7010 | -0.6265 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.08231 | 93.25 | -5.978 | -0.9792 | -0.1263 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.260 | 1.588 | 0.03066 | 0.8325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7350 | 1.528 | 1.248 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.08231</span> | 93.25 | 0.002533 | 0.2730 | 0.8814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.579 | 1.588 | 0.03066 | 0.8325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7350 | 1.528 | 1.248 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.25 | -0.08933 | -0.2508 | 0.5157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8830 | -3.835 | -1.133 | -1.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -2.153 | -0.2439 | -1.007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 476.03808 | 1.001 | -1.672 | -0.9320 | -0.9310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9291 | -0.2079 | -0.8419 | -0.7733 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.039 | -0.6026 | -0.6913 | -0.6380 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.03808 | 93.13 | -5.972 | -0.9594 | -0.1466 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.216 | 1.596 | 0.03074 | 0.8384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7314 | 1.536 | 1.259 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.03808</span> | 93.13 | 0.002548 | 0.2770 | 0.8636 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.173 | 1.596 | 0.03074 | 0.8384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7314 | 1.536 | 1.259 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.407 | -0.06545 | 0.6727 | 0.05373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4541 | -1.330 | -0.5709 | -0.1224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8702 | -1.228 | 0.2640 | -1.506 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 476.03300 | 1.003 | -1.664 | -0.9621 | -0.9598 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9520 | -0.2020 | -0.8337 | -0.7650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.042 | -0.6106 | -0.7076 | -0.6154 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.033 | 93.29 | -5.964 | -0.9878 | -0.1754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.193 | 1.599 | 0.03087 | 0.8447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7289 | 1.526 | 1.241 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.033</span> | 93.29 | 0.002569 | 0.2714 | 0.8391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.966 | 1.599 | 0.03087 | 0.8447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7289 | 1.526 | 1.241 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.25 | -0.008049 | -0.5780 | -0.5632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9601 | -0.9870 | -0.1614 | -0.08306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3446 | -1.564 | -0.5735 | -0.5777 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 475.98457 | 1.001 | -1.657 | -0.9620 | -0.9650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9284 | -0.2016 | -0.8312 | -0.7567 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -0.6004 | -0.7091 | -0.6133 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.98457 | 93.13 | -5.957 | -0.9877 | -0.1806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 1.600 | 0.03091 | 0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7262 | 1.538 | 1.240 | 1.346 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.98457</span> | 93.13 | 0.002588 | 0.2714 | 0.8347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.180 | 1.600 | 0.03091 | 0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7262 | 1.538 | 1.240 | 1.346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 475.96536 | 1.003 | -1.649 | -0.9620 | -0.9705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9043 | -0.2014 | -0.8286 | -0.7480 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.048 | -0.5903 | -0.7109 | -0.6113 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.96536 | 93.24 | -5.949 | -0.9876 | -0.1861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.241 | 1.600 | 0.03094 | 0.8576 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7235 | 1.551 | 1.238 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.96536</span> | 93.24 | 0.002608 | 0.2714 | 0.8302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.403 | 1.600 | 0.03094 | 0.8576 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7235 | 1.551 | 1.238 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 476.05821 | 1.003 | -1.627 | -0.9618 | -0.9866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8332 | -0.2007 | -0.8211 | -0.7226 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.057 | -0.5602 | -0.7159 | -0.6052 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.05821 | 93.28 | -5.927 | -0.9874 | -0.2022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.312 | 1.600 | 0.03106 | 0.8769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7156 | 1.587 | 1.233 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.05821</span> | 93.28 | 0.002666 | 0.2714 | 0.8169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 10.10 | 1.600 | 0.03106 | 0.8769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7156 | 1.587 | 1.233 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.90 | 0.05098 | -0.6601 | -0.8657 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4347 | -0.9523 | -0.3178 | -0.1283 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1024 | -0.7800 | -0.7284 | -0.4981 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 476.00714 | 1.001 | -1.643 | -0.9512 | -0.8390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8932 | -0.2051 | -0.7956 | -0.7365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -0.5599 | -0.7127 | -0.5744 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.00714 | 93.11 | -5.943 | -0.9775 | -0.05460 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.252 | 1.598 | 0.03144 | 0.8663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7264 | 1.588 | 1.236 | 1.388 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.00714</span> | 93.11 | 0.002624 | 0.2734 | 0.9469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.508 | 1.598 | 0.03144 | 0.8663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7264 | 1.588 | 1.236 | 1.388 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 475.93814 | 1.000 | -1.647 | -0.9575 | -0.9171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8999 | -0.2027 | -0.8152 | -0.7434 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.047 | -0.5779 | -0.7115 | -0.5963 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.93814 | 93.01 | -5.947 | -0.9834 | -0.1327 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.245 | 1.599 | 0.03115 | 0.8612 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7247 | 1.566 | 1.237 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.93814</span> | 93.01 | 0.002614 | 0.2722 | 0.8757 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.445 | 1.599 | 0.03115 | 0.8612 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7247 | 1.566 | 1.237 | 1.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -23.67 | 0.03897 | -0.7058 | 0.2979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2507 | -0.5051 | -0.4675 | -0.05050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.329 | -0.1594 | -0.7628 | 0.1885 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 475.98668 | 1.003 | -1.653 | -0.9119 | -0.8938 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.2050 | -0.7980 | -0.7479 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.040 | -0.5617 | -0.7056 | -0.5853 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.98668 | 93.26 | -5.953 | -0.9406 | -0.1094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.251 | 1.598 | 0.03140 | 0.8577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7310 | 1.586 | 1.243 | 1.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.98668</span> | 93.26 | 0.002598 | 0.2808 | 0.8964 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.501 | 1.598 | 0.03140 | 0.8577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7310 | 1.586 | 1.243 | 1.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 475.93401 | 1.003 | -1.649 | -0.9419 | -0.9092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8979 | -0.2035 | -0.8093 | -0.7449 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.044 | -0.5723 | -0.7094 | -0.5925 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.93401 | 93.26 | -5.949 | -0.9687 | -0.1248 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.247 | 1.599 | 0.03123 | 0.8600 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7270 | 1.573 | 1.239 | 1.369 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.93401</span> | 93.26 | 0.002609 | 0.2751 | 0.8827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.464 | 1.599 | 0.03123 | 0.8600 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7270 | 1.573 | 1.239 | 1.369 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.62 | 0.03755 | 0.3553 | 0.5344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5780 | -0.8226 | -0.2181 | -0.2167 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.049 | 0.002537 | -0.7279 | 0.2347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 475.92580 | 1.001 | -1.653 | -0.9417 | -0.9124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8966 | -0.2037 | -0.8058 | -0.7501 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.5739 | -0.7048 | -0.5926 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.9258 | 93.12 | -5.953 | -0.9686 | -0.1280 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.249 | 1.598 | 0.03129 | 0.8560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7297 | 1.571 | 1.244 | 1.369 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.9258</span> | 93.12 | 0.002598 | 0.2752 | 0.8798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.476 | 1.598 | 0.03129 | 0.8560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7297 | 1.571 | 1.244 | 1.369 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.238 | 0.003180 | 0.2025 | 0.4289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4493 | -0.2935 | -0.2270 | -0.1209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3327 | -0.04065 | -0.4864 | 0.2705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 475.92421 | 1.002 | -1.655 | -0.9475 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8971 | -0.2051 | -0.8017 | -0.7499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.041 | -0.5760 | -0.7024 | -0.5951 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.92421 | 93.14 | -5.955 | -0.9740 | -0.1336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.248 | 1.598 | 0.03135 | 0.8562 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.568 | 1.247 | 1.366 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.92421</span> | 93.14 | 0.002593 | 0.2741 | 0.8749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.472 | 1.598 | 0.03135 | 0.8562 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7299 | 1.568 | 1.247 | 1.366 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.572 | 0.0005078 | -0.07939 | 0.3039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4520 | -0.5123 | -0.2298 | -0.1955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3506 | -0.1759 | -0.3471 | 0.1717 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 475.91356 | 1.001 | -1.654 | -0.9476 | -0.9223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8992 | -0.2071 | -0.7965 | -0.7440 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.043 | -0.5749 | -0.7035 | -0.5974 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.91356 | 93.12 | -5.954 | -0.9741 | -0.1379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.246 | 1.596 | 0.03143 | 0.8607 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7278 | 1.569 | 1.246 | 1.363 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.91356</span> | 93.12 | 0.002596 | 0.2741 | 0.8712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.452 | 1.596 | 0.03143 | 0.8607 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7278 | 1.569 | 1.246 | 1.363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 475.89054 | 1.001 | -1.650 | -0.9479 | -0.9349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9054 | -0.2136 | -0.7808 | -0.7261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.051 | -0.5716 | -0.7071 | -0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.89054 | 93.11 | -5.950 | -0.9744 | -0.1505 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.240 | 1.592 | 0.03166 | 0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.89054</span> | 93.11 | 0.002606 | 0.2740 | 0.8602 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.393 | 1.592 | 0.03166 | 0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.467 | 0.05330 | -0.1133 | -0.1045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1362 | -0.3304 | -0.2172 | 0.04726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.416 | 0.08323 | -0.4566 | -0.2851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 476.06529 | 1.002 | -1.688 | -0.8959 | -0.9784 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9076 | -0.2354 | -0.6823 | -0.7302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -0.5603 | -0.6700 | -0.6079 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.06529 | 93.20 | -5.988 | -0.9255 | -0.1940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.238 | 1.579 | 0.03314 | 0.8712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7347 | 1.587 | 1.281 | 1.352 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.06529</span> | 93.20 | 0.002510 | 0.2838 | 0.8236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.372 | 1.579 | 0.03314 | 0.8712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7347 | 1.587 | 1.281 | 1.352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 475.89054 | 1.001 | -1.650 | -0.9479 | -0.9349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9054 | -0.2136 | -0.7808 | -0.7261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.051 | -0.5716 | -0.7071 | -0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.89054 | 93.11 | -5.950 | -0.9744 | -0.1505 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.240 | 1.592 | 0.03166 | 0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.89054</span> | 93.11 | 0.002606 | 0.2740 | 0.8602 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.393 | 1.592 | 0.03166 | 0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7214 | 1.574 | 1.242 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma_low | rsd_high |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 495.48573 | 1.000 | -1.000 | -0.9104 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9875 | -0.8823 | -0.8746 | -0.8907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8767 | -0.8731 | -0.8673 | -0.8720 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8739 | -0.8666 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.48573 | 91.00 | -5.200 | -0.8900 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4600 | 0.8300 | 0.05800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7311 | 0.9036 | 1.183 | 0.9554 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.48573</span> | 91.00 | 0.005517 | 0.2911 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01005 | 0.6130 | 0.8300 | 0.05800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7311 | 0.9036 | 1.183 | 0.9554 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.8633 | 1.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -0.9650 | 2.223 | -0.3153 | -0.01817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3350 | 0.6789 | -29.17 | -19.58 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9642 | 9.851 | -11.94 | -1.319 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 8.578 | -12.45 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 487.27153 | 1.023 | -1.054 | -0.9028 | -0.9372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9794 | -0.8987 | -0.1695 | -0.4175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9000 | -1.111 | -0.5788 | -0.8401 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.081 | -0.5657 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.27153 | 93.12 | -5.254 | -0.8832 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4525 | 1.123 | 0.07172 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6884 | 1.525 | 0.9859 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6843 | 1.580 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.27153</span> | 93.12 | 0.005228 | 0.2925 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.123 | 0.07172 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6884 | 1.525 | 0.9859 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6843 | 1.580 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 131.2 | 1.375 | 2.844 | -0.2311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2724 | 0.4206 | 9.234 | 14.82 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3432 | -1.547 | -2.137 | 2.699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.845 | -6.389 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 3806.3530 | 0.1967 | -1.082 | -0.9181 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9782 | -0.9073 | 0.02635 | -0.3409 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9062 | -1.204 | -0.4610 | -0.8458 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.125 | -0.4164 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 3806.353 | 17.90 | -5.282 | -0.8969 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4485 | 1.204 | 0.07394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7095 | 0.6043 | 1.664 | 0.9805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6463 | 1.761 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 3806.353</span> | 17.90 | 0.005083 | 0.2897 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01015 | 0.6103 | 1.204 | 0.07394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7095 | 0.6043 | 1.664 | 0.9805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6463 | 1.761 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 498.29847 | 0.9363 | -1.055 | -0.9047 | -0.9370 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9796 | -0.8990 | -0.1756 | -0.4273 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8998 | -1.110 | -0.5773 | -0.8419 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.078 | -0.5615 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 498.29847 | 85.20 | -5.255 | -0.8849 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4523 | 1.120 | 0.07144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7142 | 0.6894 | 1.526 | 0.9842 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6871 | 1.585 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 498.29847</span> | 85.20 | 0.005223 | 0.2922 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.120 | 0.07144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7142 | 0.6894 | 1.526 | 0.9842 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6871 | 1.585 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 485.66266 | 1.001 | -1.054 | -0.9033 | -0.9372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -0.8988 | -0.1711 | -0.4200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8999 | -1.111 | -0.5784 | -0.8406 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.080 | -0.5646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.66266 | 91.08 | -5.254 | -0.8836 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4524 | 1.122 | 0.07165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6887 | 1.525 | 0.9855 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6850 | 1.581 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.66266</span> | 91.08 | 0.005227 | 0.2924 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6112 | 1.122 | 0.07165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7141 | 0.6887 | 1.525 | 0.9855 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6850 | 1.581 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.221 | 1.276 | 0.8286 | 0.07146 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3378 | 0.6177 | 8.950 | 14.42 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.232 | -2.934 | -2.090 | 2.822 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.031 | -6.085 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 485.32609 | 0.9950 | -1.055 | -0.9042 | -0.9372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9799 | -0.8995 | -0.1813 | -0.4364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8974 | -1.108 | -0.5760 | -0.8438 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.076 | -0.5577 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.32609 | 90.54 | -5.255 | -0.8845 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4521 | 1.118 | 0.07117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7160 | 0.6917 | 1.528 | 0.9824 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6890 | 1.589 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.32609</span> | 90.54 | 0.005219 | 0.2922 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6111 | 1.118 | 0.07117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7160 | 0.6917 | 1.528 | 0.9824 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6890 | 1.589 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.72 | 1.256 | 0.2407 | 0.1468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3576 | 0.6982 | 8.550 | 13.79 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.152 | -3.092 | -1.869 | 2.672 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.399 | -5.827 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 484.94767 | 1.003 | -1.055 | -0.9045 | -0.9373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9801 | -0.8996 | -0.1956 | -0.4497 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8963 | -1.103 | -0.5795 | -0.8455 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.071 | -0.5595 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.94767 | 91.28 | -5.255 | -0.8848 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4521 | 1.112 | 0.07079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 0.6961 | 1.524 | 0.9808 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6930 | 1.587 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.94767</span> | 91.28 | 0.005220 | 0.2922 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6111 | 1.112 | 0.07079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 0.6961 | 1.524 | 0.9808 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6930 | 1.587 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.95 | 1.308 | 0.9181 | 0.03760 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3308 | 0.6549 | 8.124 | 13.74 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.975 | -2.369 | -2.107 | 2.437 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.334 | -5.928 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 484.63747 | 0.9965 | -1.055 | -0.9051 | -0.9373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9805 | -0.8998 | -0.2100 | -0.4642 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8952 | -1.098 | -0.5823 | -0.8472 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.5602 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.63747 | 90.68 | -5.255 | -0.8853 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4520 | 1.106 | 0.07037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7176 | 0.7002 | 1.521 | 0.9792 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.586 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.63747</span> | 90.68 | 0.005220 | 0.2921 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6111 | 1.106 | 0.07037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7176 | 0.7002 | 1.521 | 0.9792 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.586 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.67 | 1.288 | 0.2773 | 0.1211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3459 | 0.7203 | 8.028 | 13.24 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.967 | -2.555 | -2.117 | 2.333 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.789 | -5.812 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 484.31288 | 1.003 | -1.055 | -0.9054 | -0.9374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9808 | -0.9000 | -0.2248 | -0.4783 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8942 | -1.094 | -0.5856 | -0.8486 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.063 | -0.5617 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.31288 | 91.27 | -5.255 | -0.8855 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4519 | 1.100 | 0.06996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7183 | 0.7043 | 1.517 | 0.9778 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7003 | 1.585 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.31288</span> | 91.27 | 0.005220 | 0.2920 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6111 | 1.100 | 0.06996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7183 | 0.7043 | 1.517 | 0.9778 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7003 | 1.585 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.32 | 1.333 | 0.8110 | 0.03416 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3225 | 0.6774 | 7.502 | 12.95 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.990 | -1.849 | -2.190 | 2.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.714 | -5.891 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 484.03445 | 0.9966 | -1.055 | -0.9058 | -0.9374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9811 | -0.9003 | -0.2393 | -0.4932 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8929 | -1.090 | -0.5881 | -0.8501 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.059 | -0.5620 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.03445 | 90.69 | -5.255 | -0.8859 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4517 | 1.094 | 0.06953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7192 | 0.7079 | 1.514 | 0.9764 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7034 | 1.584 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.03445</span> | 90.69 | 0.005219 | 0.2919 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6110 | 1.094 | 0.06953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7192 | 0.7079 | 1.514 | 0.9764 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7034 | 1.584 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -23.34 | 1.311 | 0.1997 | 0.1136 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3397 | 0.7422 | 7.043 | 12.17 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.843 | -2.075 | -2.300 | 2.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.235 | -5.778 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 483.72794 | 1.003 | -1.056 | -0.9061 | -0.9374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9815 | -0.9008 | -0.2540 | -0.5081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8918 | -1.086 | -0.5906 | -0.8514 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.5623 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.72794 | 91.28 | -5.256 | -0.8861 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4515 | 1.088 | 0.06909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7200 | 0.7113 | 1.511 | 0.9751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7061 | 1.584 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.72794</span> | 91.28 | 0.005217 | 0.2919 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6110 | 1.088 | 0.06909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7200 | 0.7113 | 1.511 | 0.9751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7061 | 1.584 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.56 | 1.355 | 0.7367 | 0.03002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3166 | 0.7021 | 6.528 | 11.89 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.880 | -1.512 | -2.404 | 1.917 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.215 | -5.846 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 483.44272 | 0.9974 | -1.057 | -0.9064 | -0.9375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9820 | -0.9016 | -0.2678 | -0.5243 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8904 | -1.083 | -0.5914 | -0.8528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.054 | -0.5601 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.44272 | 90.76 | -5.257 | -0.8865 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4511 | 1.082 | 0.06862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7211 | 0.7141 | 1.510 | 0.9738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7081 | 1.587 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.44272</span> | 90.76 | 0.005212 | 0.2918 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6109 | 1.082 | 0.06862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7211 | 0.7141 | 1.510 | 0.9738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7081 | 1.587 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -19.50 | 1.332 | 0.2061 | 0.1022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3336 | 0.7519 | 5.944 | 11.09 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.878 | -1.675 | -2.404 | 1.054 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.833 | -5.715 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 483.13758 | 1.003 | -1.059 | -0.9067 | -0.9375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9826 | -0.9029 | -0.2791 | -0.5415 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8881 | -1.081 | -0.5896 | -0.8508 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -0.5541 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.13758 | 91.30 | -5.259 | -0.8867 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.595 | 0.4505 | 1.077 | 0.06813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7227 | 0.7157 | 1.512 | 0.9758 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7089 | 1.594 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.13758</span> | 91.30 | 0.005202 | 0.2918 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01010 | 0.6108 | 1.077 | 0.06813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7227 | 0.7157 | 1.512 | 0.9758 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7089 | 1.594 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.83 | 1.368 | 0.7006 | 0.02276 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3159 | 0.7144 | 5.487 | 10.74 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.773 | -1.125 | -2.251 | 1.956 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.882 | -5.671 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 482.85180 | 0.9981 | -1.062 | -0.9072 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9834 | -0.9050 | -0.2850 | -0.5582 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8853 | -1.082 | -0.5852 | -0.8503 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.053 | -0.5428 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.8518 | 90.83 | -5.262 | -0.8872 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.596 | 0.4496 | 1.075 | 0.06764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7248 | 0.7152 | 1.517 | 0.9762 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7084 | 1.607 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.8518</span> | 90.83 | 0.005184 | 0.2917 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01009 | 0.6105 | 1.075 | 0.06764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7248 | 0.7152 | 1.517 | 0.9762 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7084 | 1.607 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.64 | 1.337 | 0.2421 | 0.09047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3389 | 0.7643 | 5.051 | 10.06 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.787 | -1.445 | -2.047 | 2.073 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.627 | -5.410 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 482.60290 | 1.003 | -1.066 | -0.9079 | -0.9377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9844 | -0.9075 | -0.2858 | -0.5723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8822 | -1.083 | -0.5806 | -0.8571 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.055 | -0.5294 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.6029 | 91.28 | -5.266 | -0.8878 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.597 | 0.4484 | 1.074 | 0.06723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7271 | 0.7136 | 1.523 | 0.9697 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7072 | 1.624 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.6029</span> | 91.28 | 0.005162 | 0.2916 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01008 | 0.6103 | 1.074 | 0.06723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7271 | 0.7136 | 1.523 | 0.9697 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7072 | 1.624 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 14.50 | 1.352 | 0.6742 | 0.02192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3317 | 0.7297 | 4.803 | 9.894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.694 | -1.220 | -2.031 | 1.506 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.722 | -5.269 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 482.37953 | 0.9987 | -1.071 | -0.9090 | -0.9377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9857 | -0.9106 | -0.2840 | -0.5862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8787 | -1.084 | -0.5758 | -0.8611 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.5150 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.37953 | 90.88 | -5.271 | -0.8888 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.598 | 0.4470 | 1.075 | 0.06683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7296 | 0.7132 | 1.528 | 0.9659 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7058 | 1.641 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.37953</span> | 90.88 | 0.005137 | 0.2914 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01007 | 0.6099 | 1.075 | 0.06683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7296 | 0.7132 | 1.528 | 0.9659 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7058 | 1.641 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 482.17662 | 0.9986 | -1.077 | -0.9102 | -0.9378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9871 | -0.9141 | -0.2800 | -0.5994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8750 | -1.085 | -0.5707 | -0.8654 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.059 | -0.4996 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.17662 | 90.88 | -5.277 | -0.8898 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4454 | 1.077 | 0.06645 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7323 | 0.7123 | 1.534 | 0.9618 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7037 | 1.660 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.17662</span> | 90.88 | 0.005108 | 0.2911 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01006 | 0.6095 | 1.077 | 0.06645 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7323 | 0.7123 | 1.534 | 0.9618 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7037 | 1.660 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 481.54428 | 0.9984 | -1.097 | -0.9142 | -0.9379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9921 | -0.9262 | -0.2660 | -0.6456 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8623 | -1.088 | -0.5530 | -0.8805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.068 | -0.4457 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.54428 | 90.86 | -5.297 | -0.8934 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.605 | 0.4398 | 1.083 | 0.06511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7417 | 0.7091 | 1.555 | 0.9473 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6961 | 1.725 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.54428</span> | 90.86 | 0.005009 | 0.2904 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01001 | 0.6082 | 1.083 | 0.06511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7417 | 0.7091 | 1.555 | 0.9473 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6961 | 1.725 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 480.42060 | 0.9980 | -1.149 | -0.9249 | -0.9384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9588 | -0.2285 | -0.7695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8280 | -1.098 | -0.5055 | -0.9211 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.091 | -0.3011 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.4206 | 90.81 | -5.349 | -0.9029 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4248 | 1.098 | 0.06151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.7005 | 1.611 | 0.9085 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6759 | 1.901 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.4206</span> | 90.81 | 0.004753 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009872 | 0.6046 | 1.098 | 0.06151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7667 | 0.7005 | 1.611 | 0.9085 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6759 | 1.901 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.54 | 1.160 | -0.4282 | 0.02550 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4248 | 0.7330 | 2.572 | 4.769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.047 | -1.982 | 1.244 | -3.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.792 | -2.494 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 480.52888 | 1.003 | -1.232 | -0.9300 | -0.9345 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.037 | -1.013 | -0.2660 | -0.9542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7770 | -1.021 | -0.6177 | -0.7306 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.035 | -0.1927 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.52888 | 91.28 | -5.432 | -0.9075 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.649 | 0.3997 | 1.083 | 0.05616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8040 | 0.7699 | 1.479 | 1.091 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7247 | 2.033 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.52888</span> | 91.28 | 0.004374 | 0.2875 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009571 | 0.5986 | 1.083 | 0.05616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8040 | 0.7699 | 1.479 | 1.091 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7247 | 2.033 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 479.69850 | 1.004 | -1.189 | -0.9273 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.9850 | -0.2467 | -0.8583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8035 | -1.061 | -0.5593 | -0.8297 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2490 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.6985 | 91.34 | -5.389 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4128 | 1.091 | 0.05894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7846 | 0.7338 | 1.548 | 0.9959 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.964 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.6985</span> | 91.34 | 0.004567 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009727 | 0.6018 | 1.091 | 0.05894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7846 | 0.7338 | 1.548 | 0.9959 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.964 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.264 | 1.163 | -0.05494 | -0.06753 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3641 | 0.6248 | 0.1998 | 1.877 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5696 | 0.3809 | 0.8989 | 3.758 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2123 | -1.578 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 479.87893 | 1.001 | -1.256 | -0.9150 | -0.9312 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.045 | -1.024 | -0.2268 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7799 | -1.052 | -0.6825 | -0.8629 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.056 | -0.2060 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.87893 | 91.06 | -5.456 | -0.8941 | -2.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.658 | 0.3949 | 1.099 | 0.05789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8019 | 0.7416 | 1.402 | 0.9642 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7063 | 2.016 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.87893</span> | 91.06 | 0.004269 | 0.2903 | 0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009490 | 0.5975 | 1.099 | 0.05789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8019 | 0.7416 | 1.402 | 0.9642 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7063 | 2.016 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 479.70356 | 0.9996 | -1.214 | -0.9229 | -0.9346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9992 | -0.2397 | -0.8723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7947 | -1.058 | -0.6038 | -0.8437 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.061 | -0.2328 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.70356 | 90.96 | -5.414 | -0.9011 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4062 | 1.093 | 0.05853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7364 | 1.495 | 0.9825 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7017 | 1.984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.70356</span> | 90.96 | 0.004455 | 0.2888 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009639 | 0.6002 | 1.093 | 0.05853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7364 | 1.495 | 0.9825 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7017 | 1.984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 479.71523 | 0.9993 | -1.201 | -0.9253 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9918 | -0.2436 | -0.8656 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7992 | -1.060 | -0.5801 | -0.8379 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.063 | -0.2408 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.71523 | 90.93 | -5.401 | -0.9032 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4096 | 1.092 | 0.05873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7349 | 1.523 | 0.9880 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7004 | 1.974 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.71523</span> | 90.93 | 0.004513 | 0.2884 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009685 | 0.6010 | 1.092 | 0.05873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7349 | 1.523 | 0.9880 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.7004 | 1.974 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 479.73471 | 0.9991 | -1.194 | -0.9266 | -0.9362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9877 | -0.2457 | -0.8619 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8017 | -1.061 | -0.5670 | -0.8347 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2453 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.73471 | 90.92 | -5.394 | -0.9044 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4115 | 1.091 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7340 | 1.539 | 0.9911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6996 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.73471</span> | 90.92 | 0.004545 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009710 | 0.6015 | 1.091 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7340 | 1.539 | 0.9911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6996 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 479.71271 | 1.001 | -1.190 | -0.9273 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9854 | -0.2468 | -0.8594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8032 | -1.061 | -0.5599 | -0.8320 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2481 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.71271 | 91.05 | -5.390 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9937 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.71271</span> | 91.05 | 0.004564 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009725 | 0.6017 | 1.091 | 0.05891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9937 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 479.69386 | 1.003 | -1.189 | -0.9273 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -0.9851 | -0.2467 | -0.8587 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8034 | -1.061 | -0.5595 | -0.8305 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2487 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.69386 | 91.24 | -5.389 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4127 | 1.091 | 0.05893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7847 | 0.7338 | 1.548 | 0.9951 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.69386</span> | 91.24 | 0.004566 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009726 | 0.6017 | 1.091 | 0.05893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7847 | 0.7338 | 1.548 | 0.9951 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6994 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.722 | 1.155 | -0.1645 | -0.05121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3669 | 0.6376 | 0.06785 | 1.772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5854 | 0.2936 | 0.9229 | 3.709 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2520 | -1.579 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 479.68901 | 1.004 | -1.189 | -0.9273 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9853 | -0.2467 | -0.8591 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8033 | -1.061 | -0.5597 | -0.8314 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2483 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.68901 | 91.32 | -5.389 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05892 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7848 | 0.7337 | 1.547 | 0.9942 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68901</span> | 91.32 | 0.004565 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009725 | 0.6017 | 1.091 | 0.05892 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7848 | 0.7337 | 1.547 | 0.9942 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.772 | 1.160 | -0.07003 | -0.06455 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3646 | 0.6238 | 0.08418 | 1.806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5672 | 0.3711 | 0.9250 | 3.651 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2161 | -1.579 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 479.68474 | 1.003 | -1.190 | -0.9272 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9854 | -0.2468 | -0.8595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8031 | -1.061 | -0.5600 | -0.8323 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2479 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.68474 | 91.24 | -5.390 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4126 | 1.091 | 0.05890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9934 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68474</span> | 91.24 | 0.004563 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009724 | 0.6017 | 1.091 | 0.05890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7849 | 0.7336 | 1.547 | 0.9934 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6993 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.834 | 1.153 | -0.1599 | -0.05010 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3669 | 0.6355 | 0.09191 | 1.764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5796 | 0.2889 | 1.006 | 3.561 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2610 | -1.565 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 479.68016 | 1.004 | -1.190 | -0.9272 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9856 | -0.2468 | -0.8600 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8030 | -1.061 | -0.5602 | -0.8332 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2475 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.68016 | 91.32 | -5.390 | -0.9050 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4125 | 1.091 | 0.05889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7850 | 0.7336 | 1.547 | 0.9926 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.68016</span> | 91.32 | 0.004562 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009723 | 0.6017 | 1.091 | 0.05889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7850 | 0.7336 | 1.547 | 0.9926 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.891 | 1.158 | -0.06530 | -0.06447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3645 | 0.6207 | 0.1821 | 1.812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5486 | 0.3656 | 1.002 | 3.562 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2233 | -1.574 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 479.67614 | 1.003 | -1.190 | -0.9272 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9857 | -0.2468 | -0.8604 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8028 | -1.061 | -0.5604 | -0.8341 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2472 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.67614 | 91.24 | -5.390 | -0.9049 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4124 | 1.091 | 0.05888 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7851 | 0.7335 | 1.546 | 0.9917 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.67614</span> | 91.24 | 0.004561 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009722 | 0.6017 | 1.091 | 0.05888 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7851 | 0.7335 | 1.546 | 0.9917 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6992 | 1.966 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.915 | 1.151 | -0.1574 | -0.04977 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | 0.6321 | 0.06058 | 1.705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5691 | 0.2601 | 0.8724 | 3.420 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2638 | -1.562 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 479.67180 | 1.004 | -1.191 | -0.9271 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9859 | -0.2469 | -0.8608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8027 | -1.061 | -0.5607 | -0.8349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2468 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.6718 | 91.33 | -5.391 | -0.9049 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.4124 | 1.091 | 0.05887 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7852 | 0.7334 | 1.546 | 0.9909 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.6718</span> | 91.33 | 0.004560 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009722 | 0.6017 | 1.091 | 0.05887 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7852 | 0.7334 | 1.546 | 0.9909 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.074 | 1.157 | -0.05990 | -0.06452 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3645 | 0.6170 | 0.1286 | 1.744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5576 | 0.3161 | 0.9007 | 3.345 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2216 | -1.572 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 479.66809 | 1.003 | -1.191 | -0.9271 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9860 | -0.2469 | -0.8613 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8026 | -1.062 | -0.5609 | -0.8357 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2464 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.66809 | 91.23 | -5.391 | -0.9049 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4123 | 1.091 | 0.05885 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7853 | 0.7334 | 1.546 | 0.9901 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66809</span> | 91.23 | 0.004558 | 0.2880 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009721 | 0.6016 | 1.091 | 0.05885 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7853 | 0.7334 | 1.546 | 0.9901 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6991 | 1.967 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.161 | 1.149 | -0.1570 | -0.04911 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6293 | 0.04215 | 1.668 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5621 | 0.2625 | 0.8940 | 3.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2611 | -1.561 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 479.66397 | 1.004 | -1.191 | -0.9271 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9862 | -0.2469 | -0.8617 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8024 | -1.062 | -0.5611 | -0.8366 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2460 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.66397 | 91.33 | -5.391 | -0.9049 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4122 | 1.091 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7854 | 0.7333 | 1.546 | 0.9893 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6990 | 1.968 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66397</span> | 91.33 | 0.004557 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009720 | 0.6016 | 1.091 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7854 | 0.7333 | 1.546 | 0.9893 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6990 | 1.968 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.197 | 1.155 | -0.05534 | -0.06448 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3644 | 0.6140 | 0.1526 | 1.765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5340 | 0.3555 | 0.9900 | 3.325 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2199 | -1.571 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 479.66043 | 1.003 | -1.191 | -0.9271 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9863 | -0.2469 | -0.8621 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8023 | -1.062 | -0.5613 | -0.8374 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2456 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.66043 | 91.23 | -5.391 | -0.9048 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4122 | 1.090 | 0.05883 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7855 | 0.7332 | 1.545 | 0.9886 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.968 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.66043</span> | 91.23 | 0.004556 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009719 | 0.6016 | 1.090 | 0.05883 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7855 | 0.7332 | 1.545 | 0.9886 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.968 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.161 | 1.147 | -0.1538 | -0.04891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6262 | 0.06581 | 1.677 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5453 | 0.2828 | 1.029 | 3.251 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2683 | -1.555 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 479.65652 | 1.004 | -1.192 | -0.9270 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9865 | -0.2469 | -0.8625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8022 | -1.062 | -0.5616 | -0.8382 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2452 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.65652 | 91.33 | -5.392 | -0.9048 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4121 | 1.090 | 0.05882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7856 | 0.7332 | 1.545 | 0.9878 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.65652</span> | 91.33 | 0.004554 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009718 | 0.6016 | 1.090 | 0.05882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7856 | 0.7332 | 1.545 | 0.9878 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6989 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.221 | 1.153 | -0.05203 | -0.06424 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3643 | 0.6104 | 0.04854 | 1.680 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5365 | 0.2999 | 0.7877 | 3.080 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2284 | -1.566 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 479.65328 | 1.003 | -1.192 | -0.9270 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -0.9866 | -0.2470 | -0.8629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8020 | -1.062 | -0.5618 | -0.8389 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.064 | -0.2448 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.65328 | 91.23 | -5.392 | -0.9048 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4120 | 1.090 | 0.05880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7857 | 0.7331 | 1.545 | 0.9871 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.65328</span> | 91.23 | 0.004553 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009717 | 0.6016 | 1.090 | 0.05880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7857 | 0.7331 | 1.545 | 0.9871 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.969 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.438 | 1.145 | -0.1538 | -0.04822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3675 | 0.6235 | 0.0004265 | 1.625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5487 | 0.2329 | 0.8499 | 3.058 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2658 | -1.554 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 479.64923 | 1.004 | -1.192 | -0.9270 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9868 | -0.2469 | -0.8633 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8019 | -1.062 | -0.5621 | -0.8396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2444 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.64923 | 91.32 | -5.392 | -0.9048 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4119 | 1.091 | 0.05879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7858 | 0.7330 | 1.544 | 0.9864 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.970 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64923</span> | 91.32 | 0.004551 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009716 | 0.6015 | 1.091 | 0.05879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7858 | 0.7330 | 1.544 | 0.9864 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6988 | 1.970 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.878 | 1.150 | -0.05277 | -0.06333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3643 | 0.6074 | 0.07271 | 1.651 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5369 | 0.2992 | 0.8896 | 2.970 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2314 | -1.562 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 479.64621 | 1.003 | -1.193 | -0.9270 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9870 | -0.2469 | -0.8638 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8017 | -1.062 | -0.5623 | -0.8404 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2440 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.64621 | 91.23 | -5.393 | -0.9047 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4119 | 1.091 | 0.05878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7330 | 1.544 | 0.9856 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.970 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64621</span> | 91.23 | 0.004550 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009715 | 0.6015 | 1.091 | 0.05878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7859 | 0.7330 | 1.544 | 0.9856 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.970 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.471 | 1.143 | -0.1506 | -0.04802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3674 | 0.6203 | -0.003354 | 1.603 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5429 | 0.2243 | 0.9025 | 2.920 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2732 | -1.548 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 479.64228 | 1.004 | -1.193 | -0.9269 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9872 | -0.2468 | -0.8642 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8016 | -1.062 | -0.5627 | -0.8411 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2435 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.64228 | 91.32 | -5.393 | -0.9047 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4118 | 1.091 | 0.05877 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7860 | 0.7329 | 1.544 | 0.9850 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.971 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.64228</span> | 91.32 | 0.004548 | 0.2881 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009714 | 0.6015 | 1.091 | 0.05877 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7860 | 0.7329 | 1.544 | 0.9850 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6987 | 1.971 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.744 | 1.148 | -0.05088 | -0.06289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3642 | 0.6037 | 0.03047 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5287 | 0.2733 | 0.8334 | 2.850 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2290 | -1.558 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 479.63935 | 1.003 | -1.193 | -0.9269 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9874 | -0.2468 | -0.8646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8014 | -1.062 | -0.5630 | -0.8419 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2431 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.63935 | 91.23 | -5.393 | -0.9047 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4117 | 1.091 | 0.05876 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7861 | 0.7329 | 1.543 | 0.9843 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6986 | 1.971 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63935</span> | 91.23 | 0.004547 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009713 | 0.6015 | 1.091 | 0.05876 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7861 | 0.7329 | 1.543 | 0.9843 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6986 | 1.971 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.432 | 1.140 | -0.1464 | -0.04798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3672 | 0.6157 | -0.06295 | 1.547 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5341 | 0.1919 | 0.7582 | 2.801 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2698 | -1.544 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 479.63543 | 1.004 | -1.194 | -0.9268 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9876 | -0.2467 | -0.8650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8013 | -1.062 | -0.5633 | -0.8425 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2426 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.63543 | 91.32 | -5.394 | -0.9046 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.4116 | 1.091 | 0.05874 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7863 | 0.7328 | 1.543 | 0.9837 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.972 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63543</span> | 91.32 | 0.004545 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009712 | 0.6015 | 1.091 | 0.05874 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7863 | 0.7328 | 1.543 | 0.9837 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.972 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.612 | 1.146 | -0.04876 | -0.06242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3640 | 0.6002 | 0.04743 | 1.619 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5199 | 0.2573 | 0.7734 | 2.739 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2298 | -1.553 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 479.63248 | 1.003 | -1.194 | -0.9268 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9878 | -0.2466 | -0.8655 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8011 | -1.062 | -0.5636 | -0.8432 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2421 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.63248 | 91.23 | -5.394 | -0.9046 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4115 | 1.091 | 0.05873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7864 | 0.7328 | 1.543 | 0.9830 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.973 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.63248</span> | 91.23 | 0.004543 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009710 | 0.6014 | 1.091 | 0.05873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7864 | 0.7328 | 1.543 | 0.9830 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6985 | 1.973 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.237 | 1.138 | -0.1400 | -0.04830 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3668 | 0.6108 | -0.07665 | 1.521 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5353 | 0.1893 | 0.7456 | 2.704 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2668 | -1.543 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 479.62869 | 1.004 | -1.195 | -0.9268 | -0.9362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9880 | -0.2464 | -0.8659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8009 | -1.062 | -0.5639 | -0.8438 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2415 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.62869 | 91.32 | -5.395 | -0.9046 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4114 | 1.091 | 0.05872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7865 | 0.7327 | 1.542 | 0.9824 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6984 | 1.973 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62869</span> | 91.32 | 0.004541 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009709 | 0.6014 | 1.091 | 0.05872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7865 | 0.7327 | 1.542 | 0.9824 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6984 | 1.973 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.552 | 1.143 | -0.04554 | -0.06221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3637 | 0.5952 | -0.01323 | 1.563 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3448 | 0.2470 | 0.7924 | 2.643 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2272 | -1.550 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 479.62584 | 1.003 | -1.195 | -0.9268 | -0.9362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -0.9883 | -0.2463 | -0.8663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8008 | -1.062 | -0.5642 | -0.8446 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2410 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.62584 | 91.24 | -5.395 | -0.9046 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4113 | 1.091 | 0.05871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7866 | 0.7326 | 1.542 | 0.9817 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.974 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62584</span> | 91.24 | 0.004539 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009708 | 0.6014 | 1.091 | 0.05871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7866 | 0.7326 | 1.542 | 0.9817 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.974 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.148 | 1.135 | -0.1348 | -0.04846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3664 | 0.6063 | -0.009834 | 1.510 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5271 | 0.1803 | 0.7932 | 2.587 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2684 | -1.536 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 479.62216 | 1.004 | -1.195 | -0.9267 | -0.9362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9885 | -0.2462 | -0.8667 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8007 | -1.062 | -0.5646 | -0.8451 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2404 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.62216 | 91.32 | -5.395 | -0.9045 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4112 | 1.091 | 0.05870 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7867 | 0.7326 | 1.541 | 0.9811 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.62216</span> | 91.32 | 0.004537 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009706 | 0.6014 | 1.091 | 0.05870 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7867 | 0.7326 | 1.541 | 0.9811 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6983 | 1.975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.404 | 1.140 | -0.04564 | -0.06187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3633 | 0.5903 | -0.01970 | 1.541 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5054 | 0.2303 | 0.6483 | 2.528 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2288 | -1.542 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 479.61938 | 1.003 | -1.196 | -0.9267 | -0.9362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9887 | -0.2461 | -0.8672 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8005 | -1.062 | -0.5649 | -0.8458 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2398 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.61938 | 91.24 | -5.396 | -0.9045 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4111 | 1.091 | 0.05868 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7868 | 0.7325 | 1.541 | 0.9805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6982 | 1.975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61938</span> | 91.24 | 0.004535 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009705 | 0.6013 | 1.091 | 0.05868 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7868 | 0.7325 | 1.541 | 0.9805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6982 | 1.975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.197 | 1.132 | -0.1312 | -0.04839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3660 | 0.6012 | 0.05916 | 1.560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4869 | 0.2015 | 0.8305 | 2.573 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2666 | -1.531 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 479.61563 | 1.003 | -1.196 | -0.9266 | -0.9361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9890 | -0.2459 | -0.8676 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8003 | -1.062 | -0.5653 | -0.8464 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2392 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.61563 | 91.32 | -5.396 | -0.9044 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4109 | 1.091 | 0.05867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7870 | 0.7325 | 1.541 | 0.9799 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6981 | 1.976 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61563</span> | 91.32 | 0.004533 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009703 | 0.6013 | 1.091 | 0.05867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7870 | 0.7325 | 1.541 | 0.9799 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6981 | 1.976 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.024 | 1.137 | -0.04591 | -0.06118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3629 | 0.5856 | 0.004035 | 1.536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4978 | 0.2329 | 0.6617 | 2.436 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2318 | -1.535 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 479.61337 | 1.003 | -1.197 | -0.9266 | -0.9361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9892 | -0.2459 | -0.8680 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8001 | -1.063 | -0.5655 | -0.8471 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.065 | -0.2388 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.61337 | 91.23 | -5.397 | -0.9044 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.635 | 0.4109 | 1.091 | 0.05866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7871 | 0.7324 | 1.540 | 0.9792 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6980 | 1.977 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.61337</span> | 91.23 | 0.004531 | 0.2881 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009702 | 0.6013 | 1.091 | 0.05866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7871 | 0.7324 | 1.540 | 0.9792 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6980 | 1.977 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.815 | 1.129 | -0.1342 | -0.04706 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3660 | 0.5971 | -0.07697 | 1.438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5059 | 0.1462 | 0.6633 | 2.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2676 | -1.522 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 479.60932 | 1.003 | -1.197 | -0.9266 | -0.9361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9894 | -0.2456 | -0.8684 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8000 | -1.063 | -0.5659 | -0.8476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2381 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.60932 | 91.31 | -5.397 | -0.9044 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4107 | 1.091 | 0.05865 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7872 | 0.7324 | 1.540 | 0.9788 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.977 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60932</span> | 91.31 | 0.004529 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009700 | 0.6013 | 1.091 | 0.05865 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7872 | 0.7324 | 1.540 | 0.9788 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.977 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.699 | 1.134 | -0.04549 | -0.06017 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3630 | 0.5814 | -0.04512 | 1.484 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4915 | 0.2556 | 0.7248 | 2.322 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2317 | -1.529 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 479.60706 | 1.003 | -1.198 | -0.9265 | -0.9361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9896 | -0.2455 | -0.8689 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7998 | -1.063 | -0.5661 | -0.8484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2376 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.60706 | 91.23 | -5.398 | -0.9044 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4106 | 1.091 | 0.05863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7873 | 0.7323 | 1.540 | 0.9781 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.978 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60706</span> | 91.23 | 0.004527 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009699 | 0.6012 | 1.091 | 0.05863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7873 | 0.7323 | 1.540 | 0.9781 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6979 | 1.978 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.618 | 1.127 | -0.1276 | -0.04760 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3656 | 0.5915 | -0.08622 | 1.415 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5531 | 0.1512 | 0.6569 | 2.298 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2620 | -1.540 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 479.60314 | 1.003 | -1.198 | -0.9265 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.023 | -0.9899 | -0.2452 | -0.8692 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7996 | -1.063 | -0.5665 | -0.8488 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2369 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.60314 | 91.31 | -5.398 | -0.9043 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4105 | 1.091 | 0.05862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7875 | 0.7322 | 1.539 | 0.9776 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.979 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60314</span> | 91.31 | 0.004525 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009698 | 0.6012 | 1.091 | 0.05862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7875 | 0.7322 | 1.539 | 0.9776 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.979 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.641 | 1.131 | -0.04213 | -0.06002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3627 | 0.5770 | -0.05114 | 1.464 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4913 | 0.1735 | 0.5980 | 2.238 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2116 | -1.521 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 479.60093 | 1.003 | -1.199 | -0.9265 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9901 | -0.2452 | -0.8697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7994 | -1.063 | -0.5667 | -0.8495 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2363 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.60093 | 91.23 | -5.399 | -0.9043 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4104 | 1.091 | 0.05861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7876 | 0.7322 | 1.539 | 0.9769 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.980 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.60093</span> | 91.23 | 0.004523 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009696 | 0.6012 | 1.091 | 0.05861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7876 | 0.7322 | 1.539 | 0.9769 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.980 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.657 | 1.124 | -0.1240 | -0.04721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3655 | 0.5872 | -0.09119 | 1.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4948 | 0.1646 | 0.6965 | 2.186 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2747 | -1.512 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 479.59701 | 1.003 | -1.199 | -0.9264 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9904 | -0.2448 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7992 | -1.063 | -0.5670 | -0.8499 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2356 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.59701 | 91.31 | -5.399 | -0.9043 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4103 | 1.091 | 0.05860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7321 | 1.539 | 0.9766 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.980 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.59701</span> | 91.31 | 0.004520 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009695 | 0.6012 | 1.091 | 0.05860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7877 | 0.7321 | 1.539 | 0.9766 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.980 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.447 | 1.128 | -0.03826 | -0.05934 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3628 | 0.5721 | -0.04376 | 1.440 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4844 | 0.2233 | -0.3355 | 1.410 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3677 | -1.539 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 479.59436 | 1.003 | -1.200 | -0.9264 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9907 | -0.2446 | -0.8705 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7990 | -1.063 | -0.5669 | -0.8504 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2349 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.59436 | 91.23 | -5.400 | -0.9042 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.636 | 0.4102 | 1.091 | 0.05858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7879 | 0.7320 | 1.539 | 0.9761 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.981 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.59436</span> | 91.23 | 0.004518 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009693 | 0.6011 | 1.091 | 0.05858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7879 | 0.7320 | 1.539 | 0.9761 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.981 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.478 | 1.121 | -0.1165 | -0.04761 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3651 | 0.5835 | -0.09604 | 1.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4943 | 0.1086 | -0.4551 | 1.395 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3088 | -1.502 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 479.58979 | 1.003 | -1.200 | -0.9263 | -0.9359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9910 | -0.2442 | -0.8708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7988 | -1.063 | -0.5665 | -0.8506 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2341 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.58979 | 91.30 | -5.400 | -0.9042 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4100 | 1.092 | 0.05858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7880 | 0.7319 | 1.539 | 0.9759 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.982 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58979</span> | 91.30 | 0.004516 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009691 | 0.6011 | 1.092 | 0.05858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7880 | 0.7319 | 1.539 | 0.9759 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.982 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.813 | 1.125 | -0.03904 | -0.05862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3624 | 0.5728 | -0.008587 | 1.448 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2657 | 0.1639 | 0.6610 | 2.108 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2622 | -1.501 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 479.58727 | 1.003 | -1.201 | -0.9263 | -0.9359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9912 | -0.2441 | -0.8713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7987 | -1.063 | -0.5668 | -0.8514 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2335 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.58727 | 91.24 | -5.401 | -0.9042 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4099 | 1.092 | 0.05856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7881 | 0.7318 | 1.539 | 0.9751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.983 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58727</span> | 91.24 | 0.004513 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009690 | 0.6011 | 1.092 | 0.05856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7881 | 0.7318 | 1.539 | 0.9751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.983 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.987 | 1.119 | -0.1055 | -0.04878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3644 | 0.5797 | -0.03160 | 1.359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4809 | 0.09403 | -0.4184 | 1.337 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2770 | -1.489 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 479.58366 | 1.004 | -1.201 | -0.9263 | -0.9359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.024 | -0.9915 | -0.2438 | -0.8717 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7986 | -1.063 | -0.5667 | -0.8517 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2327 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.58366 | 91.32 | -5.401 | -0.9041 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4098 | 1.092 | 0.05855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7882 | 0.7317 | 1.539 | 0.9749 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.58366</span> | 91.32 | 0.004511 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009688 | 0.6010 | 1.092 | 0.05855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7882 | 0.7317 | 1.539 | 0.9749 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6978 | 1.984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.434 | 1.122 | -0.01954 | -0.06326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3597 | 0.5645 | -0.03484 | 1.404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4782 | 0.1697 | -0.05991 | 1.573 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2504 | -1.489 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 479.57994 | 1.003 | -1.202 | -0.9262 | -0.9358 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9918 | -0.2433 | -0.8720 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7984 | -1.063 | -0.5664 | -0.8520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2319 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.57994 | 91.26 | -5.402 | -0.9041 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4096 | 1.092 | 0.05854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7884 | 0.7316 | 1.539 | 0.9746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.985 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57994</span> | 91.26 | 0.004508 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009686 | 0.6010 | 1.092 | 0.05854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7884 | 0.7316 | 1.539 | 0.9746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6977 | 1.985 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.328 | 1.117 | -0.07952 | -0.05137 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3636 | 0.5738 | 0.02815 | 1.418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4669 | 0.1345 | 0.7258 | 2.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2949 | -1.476 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 479.57683 | 1.004 | -1.202 | -0.9262 | -0.9358 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9921 | -0.2431 | -0.8724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7982 | -1.064 | -0.5667 | -0.8526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2311 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.57683 | 91.32 | -5.402 | -0.9041 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4095 | 1.092 | 0.05853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7885 | 0.7315 | 1.539 | 0.9740 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.986 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57683</span> | 91.32 | 0.004505 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009684 | 0.6010 | 1.092 | 0.05853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7885 | 0.7315 | 1.539 | 0.9740 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6976 | 1.986 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.369 | 1.121 | -0.01236 | -0.06033 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3618 | 0.5608 | -0.009614 | 1.424 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4677 | 0.1416 | 0.6194 | 1.932 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2634 | -1.483 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 479.57433 | 1.003 | -1.203 | -0.9262 | -0.9358 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9924 | -0.2429 | -0.8728 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7980 | -1.064 | -0.5671 | -0.8530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2304 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.57433 | 91.25 | -5.403 | -0.9041 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.4094 | 1.092 | 0.05852 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7886 | 0.7315 | 1.539 | 0.9736 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 1.987 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57433</span> | 91.25 | 0.004503 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009683 | 0.6009 | 1.092 | 0.05852 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7886 | 0.7315 | 1.539 | 0.9736 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 1.987 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.507 | 1.111 | -0.09183 | -0.05192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3614 | 0.5665 | -0.03887 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4753 | 0.07826 | 0.5528 | 1.905 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2844 | -1.468 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 479.57116 | 1.003 | -1.204 | -0.9262 | -0.9357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9927 | -0.2425 | -0.8732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7978 | -1.064 | -0.5674 | -0.8534 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2297 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.57116 | 91.32 | -5.404 | -0.9040 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4092 | 1.092 | 0.05851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7888 | 0.7315 | 1.538 | 0.9732 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6973 | 1.988 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57116</span> | 91.32 | 0.004500 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009681 | 0.6009 | 1.092 | 0.05851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7888 | 0.7315 | 1.538 | 0.9732 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6973 | 1.988 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.953 | 1.117 | -0.01332 | -0.05913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3618 | 0.5550 | -0.01942 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4588 | 0.1396 | 0.5378 | 1.901 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2564 | -1.475 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 479.56857 | 1.003 | -1.204 | -0.9261 | -0.9357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -0.9930 | -0.2422 | -0.8735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7976 | -1.064 | -0.5677 | -0.8539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.2289 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.56857 | 91.25 | -5.404 | -0.9040 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4091 | 1.092 | 0.05850 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7889 | 0.7314 | 1.538 | 0.9728 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6972 | 1.989 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56857</span> | 91.25 | 0.004497 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009679 | 0.6009 | 1.092 | 0.05850 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7889 | 0.7314 | 1.538 | 0.9728 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6972 | 1.989 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.279 | 1.109 | -0.08378 | -0.05051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3625 | 0.5609 | -0.06234 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5093 | 0.06989 | -1.266 | 1.852 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2753 | -1.463 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 479.56430 | 1.003 | -1.205 | -0.9261 | -0.9357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9933 | -0.2419 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7974 | -1.064 | -0.5672 | -0.8543 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2281 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.5643 | 91.31 | -5.405 | -0.9040 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4090 | 1.093 | 0.05849 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7891 | 0.7314 | 1.538 | 0.9724 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6971 | 1.990 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.5643</span> | 91.31 | 0.004495 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009677 | 0.6008 | 1.093 | 0.05849 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7891 | 0.7314 | 1.538 | 0.9724 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6971 | 1.990 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.181 | 1.113 | -0.01711 | -0.05862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3610 | 0.5490 | -0.06295 | 1.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4495 | 0.1474 | 0.6781 | 1.913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2455 | -1.468 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 479.56239 | 1.003 | -1.205 | -0.9261 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9935 | -0.2417 | -0.8744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7972 | -1.064 | -0.5674 | -0.8549 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2275 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.56239 | 91.24 | -5.405 | -0.9040 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4089 | 1.093 | 0.05847 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7892 | 0.7313 | 1.538 | 0.9718 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6970 | 1.990 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56239</span> | 91.24 | 0.004493 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009675 | 0.6008 | 1.093 | 0.05847 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7892 | 0.7313 | 1.538 | 0.9718 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6970 | 1.990 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.516 | 1.106 | -0.09308 | -0.04714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3636 | 0.5580 | -0.04406 | 1.488 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4662 | 0.05187 | 0.6104 | 1.787 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2769 | -1.453 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 479.55877 | 1.003 | -1.206 | -0.9261 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9938 | -0.2414 | -0.8747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7970 | -1.064 | -0.5678 | -0.8553 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2268 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.55877 | 91.31 | -5.406 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.638 | 0.4087 | 1.093 | 0.05846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7894 | 0.7313 | 1.538 | 0.9714 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6969 | 1.991 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55877</span> | 91.31 | 0.004490 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009674 | 0.6008 | 1.093 | 0.05846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7894 | 0.7313 | 1.538 | 0.9714 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6969 | 1.991 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.254 | 1.111 | -0.01255 | -0.05783 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3613 | 0.5437 | -0.01079 | 1.366 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4954 | 0.1048 | 0.5565 | 1.745 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2417 | -1.458 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 479.55696 | 1.003 | -1.206 | -0.9261 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9940 | -0.2413 | -0.8753 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7968 | -1.064 | -0.5681 | -0.8559 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2262 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.55696 | 91.24 | -5.406 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4086 | 1.093 | 0.05845 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7895 | 0.7312 | 1.537 | 0.9708 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.992 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55696</span> | 91.24 | 0.004488 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009672 | 0.6008 | 1.093 | 0.05845 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7895 | 0.7312 | 1.537 | 0.9708 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6968 | 1.992 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.420 | 1.104 | -0.08938 | -0.04652 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3638 | 0.5524 | -0.03600 | 1.474 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4537 | 0.08714 | 0.5943 | 1.686 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2777 | -1.443 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 479.55331 | 1.003 | -1.207 | -0.9260 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9943 | -0.2409 | -0.8756 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7966 | -1.064 | -0.5684 | -0.8562 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2254 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.55331 | 91.31 | -5.407 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4085 | 1.093 | 0.05844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7897 | 0.7312 | 1.537 | 0.9706 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.993 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55331</span> | 91.31 | 0.004485 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009670 | 0.6007 | 1.093 | 0.05844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7897 | 0.7312 | 1.537 | 0.9706 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.993 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.940 | 1.107 | -0.01326 | -0.05734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3610 | 0.5380 | -0.03050 | 1.334 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4419 | 0.09953 | 0.4758 | 1.660 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2363 | -1.448 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 479.55178 | 1.003 | -1.208 | -0.9260 | -0.9355 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.026 | -0.9945 | -0.2409 | -0.8762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7964 | -1.064 | -0.5686 | -0.8569 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2248 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.55178 | 91.23 | -5.408 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4084 | 1.093 | 0.05842 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 0.7311 | 1.537 | 0.9699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.994 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.55178</span> | 91.23 | 0.004483 | 0.2882 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009668 | 0.6007 | 1.093 | 0.05842 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7898 | 0.7311 | 1.537 | 0.9699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.994 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.846 | 1.100 | -0.09130 | -0.04553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3638 | 0.5474 | -0.02936 | 1.430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4494 | 0.05105 | 0.6245 | 1.611 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2724 | -1.435 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 479.54790 | 1.003 | -1.208 | -0.9260 | -0.9355 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9948 | -0.2405 | -0.8765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7962 | -1.064 | -0.5690 | -0.8571 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2240 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.5479 | 91.30 | -5.408 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4083 | 1.093 | 0.05841 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7899 | 0.7311 | 1.536 | 0.9697 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.995 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.5479</span> | 91.30 | 0.004480 | 0.2883 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009667 | 0.6007 | 1.093 | 0.05841 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7899 | 0.7311 | 1.536 | 0.9697 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.995 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.570 | 1.104 | -0.01594 | -0.05674 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3607 | 0.5327 | -0.02577 | 1.253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4401 | 0.07544 | -0.5163 | 0.8741 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3456 | -1.445 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 479.54587 | 1.003 | -1.209 | -0.9260 | -0.9355 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9951 | -0.2405 | -0.8771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7960 | -1.064 | -0.5687 | -0.8576 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2233 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.54587 | 91.23 | -5.409 | -0.9039 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4081 | 1.093 | 0.05839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7901 | 0.7310 | 1.537 | 0.9693 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.995 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.54587</span> | 91.23 | 0.004478 | 0.2883 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009665 | 0.6006 | 1.093 | 0.05839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7901 | 0.7310 | 1.537 | 0.9693 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.995 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.902 | 1.097 | -0.08880 | -0.04568 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3633 | 0.5436 | -0.03820 | 1.421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4438 | 0.04451 | 0.5507 | 1.558 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2862 | -1.423 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 479.54157 | 1.003 | -1.209 | -0.9260 | -0.9354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9954 | -0.2399 | -0.8773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7958 | -1.064 | -0.5687 | -0.8577 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.54157 | 91.30 | -5.409 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.639 | 0.4080 | 1.093 | 0.05839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7902 | 0.7309 | 1.537 | 0.9691 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.996 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.54157</span> | 91.30 | 0.004475 | 0.2883 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009663 | 0.6006 | 1.093 | 0.05839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7902 | 0.7309 | 1.537 | 0.9691 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.996 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.063 | 1.100 | -0.01768 | -0.05631 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3603 | 0.5311 | -0.05904 | 1.468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4400 | 0.06384 | 0.5216 | 1.564 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2548 | -1.433 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 479.53906 | 1.003 | -1.210 | -0.9259 | -0.9354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9956 | -0.2399 | -0.8780 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7956 | -1.064 | -0.5689 | -0.8584 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2218 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.53906 | 91.25 | -5.410 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4079 | 1.093 | 0.05837 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7904 | 0.7309 | 1.536 | 0.9684 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.997 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53906</span> | 91.25 | 0.004472 | 0.2883 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009661 | 0.6006 | 1.093 | 0.05837 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7904 | 0.7309 | 1.536 | 0.9684 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 1.997 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.131 | 1.095 | -0.06506 | -0.04908 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3620 | 0.5356 | -0.007514 | 1.441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4274 | 0.08578 | -0.3543 | 0.8441 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2944 | -1.418 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 479.53616 | 1.004 | -1.210 | -0.9259 | -0.9354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.027 | -0.9959 | -0.2396 | -0.8785 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7954 | -1.064 | -0.5688 | -0.8586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2210 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.53616 | 91.33 | -5.410 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4077 | 1.094 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7905 | 0.7308 | 1.537 | 0.9682 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.998 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53616</span> | 91.33 | 0.004470 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009659 | 0.6005 | 1.094 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7905 | 0.7308 | 1.537 | 0.9682 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 1.998 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.979 | 1.099 | 0.01619 | -0.06233 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3580 | 0.5217 | -0.09749 | 1.245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4289 | 0.1115 | -0.5282 | 0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3266 | -1.417 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 479.53242 | 1.003 | -1.211 | -0.9259 | -0.9353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9962 | -0.2391 | -0.8787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7953 | -1.065 | -0.5685 | -0.8588 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2202 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.53242 | 91.27 | -5.411 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4076 | 1.094 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7906 | 0.7307 | 1.537 | 0.9681 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.999 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53242</span> | 91.27 | 0.004467 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009657 | 0.6005 | 1.094 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7906 | 0.7307 | 1.537 | 0.9681 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 1.999 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.679 | 1.093 | -0.04308 | -0.05224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3605 | 0.5318 | -0.002555 | 1.446 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4215 | 0.05786 | 0.6079 | 1.538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2997 | -1.401 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 479.52958 | 1.004 | -1.212 | -0.9259 | -0.9353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9965 | -0.2388 | -0.8793 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7951 | -1.065 | -0.5686 | -0.8593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2194 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.52958 | 91.33 | -5.412 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4075 | 1.094 | 0.05833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7908 | 0.7306 | 1.537 | 0.9676 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.000 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52958</span> | 91.33 | 0.004464 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009655 | 0.6005 | 1.094 | 0.05833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7908 | 0.7306 | 1.537 | 0.9676 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.000 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.139 | 1.094 | 0.01046 | -0.06226 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3570 | 0.5194 | -0.09592 | 1.421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4323 | 0.06052 | -0.5454 | 0.7071 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2962 | -1.410 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 479.52646 | 1.003 | -1.212 | -0.9259 | -0.9353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9968 | -0.2384 | -0.8797 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7949 | -1.065 | -0.5684 | -0.8594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2186 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.52646 | 91.26 | -5.412 | -0.9038 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.640 | 0.4073 | 1.094 | 0.05832 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7909 | 0.7304 | 1.537 | 0.9675 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.001 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52646</span> | 91.26 | 0.004461 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009653 | 0.6005 | 1.094 | 0.05832 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7909 | 0.7304 | 1.537 | 0.9675 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.001 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.758 | 1.088 | -0.05217 | -0.05158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3593 | 0.5291 | -0.05980 | 1.185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4227 | -2.218 | -0.3659 | 0.8223 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2423 | -1.392 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 479.52294 | 1.003 | -1.213 | -0.9258 | -0.9352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9971 | -0.2379 | -0.8800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7947 | -1.064 | -0.5681 | -0.8596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2178 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.52294 | 91.30 | -5.413 | -0.9037 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4072 | 1.094 | 0.05831 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7311 | 1.537 | 0.9673 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6967 | 2.002 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52294</span> | 91.30 | 0.004458 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009652 | 0.6004 | 1.094 | 0.05831 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7910 | 0.7311 | 1.537 | 0.9673 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6967 | 2.002 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.7571 | 1.091 | -0.01328 | -0.05733 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3573 | 0.5211 | 0.006105 | 1.423 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4119 | 0.1268 | 0.6771 | 1.465 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3146 | -1.386 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 479.52041 | 1.003 | -1.213 | -0.9258 | -0.9352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.028 | -0.9973 | -0.2380 | -0.8807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7945 | -1.064 | -0.5684 | -0.8604 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.52041 | 91.27 | -5.413 | -0.9037 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4071 | 1.094 | 0.05829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7912 | 0.7311 | 1.537 | 0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.003 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.52041</span> | 91.27 | 0.004456 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009650 | 0.6004 | 1.094 | 0.05829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7912 | 0.7311 | 1.537 | 0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6965 | 2.003 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.400 | 1.087 | -0.04852 | -0.05189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3585 | 0.5236 | -0.05100 | 1.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4319 | 0.01564 | 0.3566 | 1.324 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.3221 | -1.379 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 479.51911 | 1.004 | -1.214 | -0.9258 | -0.9352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9976 | -0.2379 | -0.8812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7944 | -1.064 | -0.5686 | -0.8609 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2166 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.51911 | 91.35 | -5.414 | -0.9037 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4070 | 1.094 | 0.05828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7913 | 0.7310 | 1.537 | 0.9661 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.004 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51911</span> | 91.35 | 0.004454 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009648 | 0.6004 | 1.094 | 0.05828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7913 | 0.7310 | 1.537 | 0.9661 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.004 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.458 | 1.092 | 0.04306 | -0.06507 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3552 | 0.5068 | -0.06807 | 1.418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4090 | 0.1358 | -0.5109 | 0.5676 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2804 | -1.390 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 479.51487 | 1.003 | -1.215 | -0.9258 | -0.9352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9978 | -0.2377 | -0.8817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7942 | -1.064 | -0.5685 | -0.8612 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2158 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.51487 | 91.27 | -5.415 | -0.9037 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4069 | 1.094 | 0.05826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7914 | 0.7307 | 1.537 | 0.9658 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.005 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51487</span> | 91.27 | 0.004451 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009647 | 0.6003 | 1.094 | 0.05826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7914 | 0.7307 | 1.537 | 0.9658 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.005 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.582 | 1.084 | -0.03533 | -0.05340 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3581 | 0.5175 | -0.06480 | 1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4224 | 0.03489 | -0.5536 | 0.6041 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2386 | -1.371 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 479.51208 | 1.004 | -1.215 | -0.9258 | -0.9351 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9981 | -0.2375 | -0.8823 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7939 | -1.065 | -0.5682 | -0.8615 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2150 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.51208 | 91.34 | -5.415 | -0.9037 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.641 | 0.4067 | 1.094 | 0.05824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7916 | 0.7306 | 1.537 | 0.9655 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.006 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.51208</span> | 91.34 | 0.004449 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009645 | 0.6003 | 1.094 | 0.05824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7916 | 0.7306 | 1.537 | 0.9655 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.006 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.943 | 1.087 | 0.02817 | -0.06279 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3555 | 0.5065 | -0.06060 | 1.305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4115 | 0.06912 | 0.4865 | 1.240 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2990 | -1.371 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 479.50842 | 1.003 | -1.216 | -0.9258 | -0.9351 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9984 | -0.2372 | -0.8827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7937 | -1.065 | -0.5683 | -0.8618 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2141 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.50842 | 91.29 | -5.416 | -0.9037 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4066 | 1.095 | 0.05823 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7918 | 0.7302 | 1.537 | 0.9652 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6962 | 2.007 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.50842</span> | 91.29 | 0.004446 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009643 | 0.6003 | 1.095 | 0.05823 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7918 | 0.7302 | 1.537 | 0.9652 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6962 | 2.007 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7463 | 1.081 | -0.02105 | -0.05532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3572 | 0.5118 | -0.07839 | 1.134 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4206 | 0.01709 | -0.5616 | 0.5218 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2429 | -1.361 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 479.50515 | 1.004 | -1.216 | -0.9258 | -0.9351 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.029 | -0.9987 | -0.2372 | -0.8834 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7935 | -1.065 | -0.5680 | -0.8621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2133 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.50515 | 91.33 | -5.416 | -0.9037 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4065 | 1.095 | 0.05821 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7919 | 0.7302 | 1.537 | 0.9649 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.008 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.50515</span> | 91.33 | 0.004443 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009641 | 0.6002 | 1.095 | 0.05821 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7919 | 0.7302 | 1.537 | 0.9649 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.008 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 479.49887 | 1.004 | -1.219 | -0.9257 | -0.9350 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.030 | -0.9997 | -0.2363 | -0.8851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7928 | -1.066 | -0.5675 | -0.8630 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2104 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.49887 | 91.39 | -5.419 | -0.9037 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.642 | 0.4060 | 1.095 | 0.05816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7925 | 0.7293 | 1.538 | 0.9641 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.011 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.49887</span> | 91.39 | 0.004434 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009634 | 0.6001 | 1.095 | 0.05816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7925 | 0.7293 | 1.538 | 0.9641 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.011 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.922 | 1.081 | 0.1004 | -0.07252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3520 | 0.4871 | 0.2543 | 1.578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3854 | 0.03465 | -0.5794 | 0.4083 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2550 | -1.344 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 479.48147 | 1.003 | -1.221 | -0.9257 | -0.9348 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.031 | -1.001 | -0.2344 | -0.8861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7921 | -1.067 | -0.5658 | -0.8636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2068 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.48147 | 91.29 | -5.421 | -0.9036 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.643 | 0.4054 | 1.096 | 0.05813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7930 | 0.7283 | 1.540 | 0.9635 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.016 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.48147</span> | 91.29 | 0.004421 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009626 | 0.6000 | 1.096 | 0.05813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7930 | 0.7283 | 1.540 | 0.9635 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6963 | 2.016 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 479.46291 | 1.003 | -1.226 | -0.9256 | -0.9345 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.032 | -1.003 | -0.2312 | -0.8874 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7910 | -1.069 | -0.5631 | -0.8644 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.2012 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.46291 | 91.29 | -5.426 | -0.9035 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.645 | 0.4045 | 1.097 | 0.05809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7937 | 0.7267 | 1.543 | 0.9627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.022 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.46291</span> | 91.29 | 0.004402 | 0.2883 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009612 | 0.5998 | 1.097 | 0.05809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7937 | 0.7267 | 1.543 | 0.9627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6964 | 2.022 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 479.38653 | 1.003 | -1.248 | -0.9250 | -0.9332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.039 | -1.013 | -0.2154 | -0.8940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7859 | -1.078 | -0.5497 | -0.8687 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.067 | -0.1734 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.38653 | 91.26 | -5.448 | -0.9030 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.652 | 0.4000 | 1.104 | 0.05790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7975 | 0.7188 | 1.559 | 0.9587 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.056 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.38653</span> | 91.26 | 0.004306 | 0.2884 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009547 | 0.5987 | 1.104 | 0.05790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7975 | 0.7188 | 1.559 | 0.9587 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6966 | 2.056 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 479.33405 | 1.002 | -1.333 | -0.9226 | -0.9281 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.066 | -1.051 | -0.1533 | -0.9198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7659 | -1.112 | -0.4971 | -0.8853 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.066 | -0.06439 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.33405 | 91.15 | -5.533 | -0.9008 | -2.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.678 | 0.3823 | 1.129 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8121 | 0.6876 | 1.621 | 0.9427 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 2.188 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.33405</span> | 91.15 | 0.003953 | 0.2889 | 0.1119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009294 | 0.5944 | 1.129 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8121 | 0.6876 | 1.621 | 0.9427 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6975 | 2.188 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.35 | 0.8049 | 0.3265 | -0.06456 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3038 | 0.2091 | 1.763 | 1.473 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5535 | -2.463 | 1.244 | -0.6274 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.702 | -0.2760 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 479.70817 | 1.005 | -1.492 | -0.9504 | -0.9122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.121 | -1.106 | -0.1774 | -0.9510 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7305 | -1.145 | -0.4385 | -0.8800 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.177 | -0.01012 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.70817 | 91.47 | -5.692 | -0.9256 | -2.175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.734 | 0.3572 | 1.119 | 0.05625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 0.6579 | 1.691 | 0.9478 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6020 | 2.254 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.70817</span> | 91.47 | 0.003371 | 0.2838 | 0.1137 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008794 | 0.5884 | 1.119 | 0.05625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8380 | 0.6579 | 1.691 | 0.9478 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6020 | 2.254 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 479.27063 | 1.005 | -1.375 | -0.9298 | -0.9240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.080 | -1.065 | -0.1597 | -0.9281 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7567 | -1.120 | -0.4820 | -0.8839 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.095 | -0.05030 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.27063 | 91.42 | -5.575 | -0.9073 | -2.186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.693 | 0.3758 | 1.127 | 0.05692 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8189 | 0.6801 | 1.639 | 0.9441 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6726 | 2.206 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.27063</span> | 91.42 | 0.003793 | 0.2876 | 0.1123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009162 | 0.5929 | 1.127 | 0.05692 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8189 | 0.6801 | 1.639 | 0.9441 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6726 | 2.206 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.862 | 0.7516 | 0.3576 | -0.07893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2806 | -0.4298 | 1.369 | 1.213 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5227 | -2.562 | 2.801 | -1.010 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.234 | -0.5388 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 479.18239 | 1.005 | -1.423 | -0.9401 | -0.9189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1729 | -0.9195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7414 | -1.117 | -0.4967 | -0.8806 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04375 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.18239 | 91.43 | -5.623 | -0.9165 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.710 | 0.3764 | 1.121 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.6834 | 1.622 | 0.9472 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.213 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.18239</span> | 91.43 | 0.003613 | 0.2857 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009001 | 0.5930 | 1.121 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.6834 | 1.622 | 0.9472 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.213 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.797 | 0.6564 | -0.1913 | -0.04289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2359 | -0.3012 | 1.209 | 1.124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4349 | -2.322 | 2.160 | -0.7215 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1578 | -0.4171 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 479.53483 | 0.9938 | -1.508 | -0.8927 | -0.9141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.127 | -1.054 | -0.1802 | -0.9016 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7110 | -1.089 | -0.5260 | -0.8567 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.093 | -0.01567 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.53483 | 90.44 | -5.708 | -0.8742 | -2.177 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.740 | 0.3812 | 1.118 | 0.05768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8523 | 0.7081 | 1.587 | 0.9700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6741 | 2.248 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.53483</span> | 90.44 | 0.003320 | 0.2944 | 0.1134 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008741 | 0.5942 | 1.118 | 0.05768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8523 | 0.7081 | 1.587 | 0.9700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6741 | 2.248 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 479.57437 | 0.9943 | -1.436 | -0.9336 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.102 | -1.062 | -0.1777 | -0.9209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7362 | -1.106 | -0.5073 | -0.8753 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03890 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.57437 | 90.49 | -5.636 | -0.9106 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.715 | 0.3775 | 1.119 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | 0.6933 | 1.609 | 0.9523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.57437</span> | 90.49 | 0.003567 | 0.2869 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008961 | 0.5933 | 1.119 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | 0.6933 | 1.609 | 0.9523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 479.18328 | 1.003 | -1.424 | -0.9400 | -0.9189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1736 | -0.9201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7412 | -1.115 | -0.4980 | -0.8802 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04351 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.18328 | 91.28 | -5.624 | -0.9164 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6847 | 1.620 | 0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.18328</span> | 91.28 | 0.003612 | 0.2857 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009000 | 0.5930 | 1.121 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6847 | 1.620 | 0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 479.17990 | 1.004 | -1.423 | -0.9401 | -0.9189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1732 | -0.9198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7413 | -1.116 | -0.4973 | -0.8805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04364 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.1799 | 91.36 | -5.623 | -0.9164 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.710 | 0.3764 | 1.121 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8301 | 0.6840 | 1.621 | 0.9474 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.1799</span> | 91.36 | 0.003612 | 0.2857 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009001 | 0.5930 | 1.121 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8301 | 0.6840 | 1.621 | 0.9474 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.933 | 0.6514 | -0.2757 | -0.03244 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2382 | -0.2823 | 1.183 | 1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4397 | -2.345 | 2.145 | -0.7620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1240 | -0.3947 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 479.17667 | 1.005 | -1.424 | -0.9399 | -0.9189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1735 | -0.9200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7411 | -1.116 | -0.4978 | -0.8802 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04350 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.17667 | 91.44 | -5.624 | -0.9162 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6845 | 1.621 | 0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17667</span> | 91.44 | 0.003611 | 0.2857 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009000 | 0.5930 | 1.121 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8302 | 0.6845 | 1.621 | 0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.521 | 0.6547 | -0.1751 | -0.04313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2353 | -0.2995 | 1.118 | 1.121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4506 | -2.323 | 2.084 | -0.7259 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1653 | -0.4503 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 479.17418 | 1.004 | -1.424 | -0.9398 | -0.9188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1738 | -0.9202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7410 | -1.115 | -0.4983 | -0.8800 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04335 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.17418 | 91.36 | -5.624 | -0.9161 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3765 | 1.121 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8303 | 0.6850 | 1.620 | 0.9478 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17418</span> | 91.36 | 0.003610 | 0.2857 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008999 | 0.5930 | 1.121 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8303 | 0.6850 | 1.620 | 0.9478 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.859 | 0.6491 | -0.2708 | -0.03145 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2380 | -0.2786 | 1.113 | 1.074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4387 | -2.285 | 2.045 | -0.7498 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1354 | -0.4011 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 479.17107 | 1.005 | -1.424 | -0.9396 | -0.9188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.098 | -1.064 | -0.1740 | -0.9204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7408 | -1.114 | -0.4988 | -0.8798 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04320 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.17107 | 91.44 | -5.624 | -0.9160 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3766 | 1.121 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8305 | 0.6855 | 1.619 | 0.9480 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.17107</span> | 91.44 | 0.003609 | 0.2858 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008997 | 0.5930 | 1.121 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8305 | 0.6855 | 1.619 | 0.9480 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6831 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.569 | 0.6522 | -0.1642 | -0.04243 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2349 | -0.2958 | 1.101 | 1.106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4222 | -2.201 | 1.058 | -0.2096 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2358 | -0.4015 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 479.16873 | 1.004 | -1.425 | -0.9393 | -0.9188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.064 | -0.1743 | -0.9206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7406 | -1.114 | -0.4991 | -0.8797 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04303 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.16873 | 91.36 | -5.625 | -0.9158 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3766 | 1.121 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8306 | 0.6860 | 1.619 | 0.9481 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16873</span> | 91.36 | 0.003607 | 0.2858 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008996 | 0.5931 | 1.121 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8306 | 0.6860 | 1.619 | 0.9481 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.214 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.833 | 0.6464 | -0.2551 | -0.03020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2388 | -0.2745 | 1.092 | 1.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4378 | -2.238 | 1.100 | -0.2036 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2823 | -0.3907 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 479.16547 | 1.005 | -1.426 | -0.9390 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1745 | -0.9206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7403 | -1.113 | -0.4993 | -0.8795 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04283 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.16547 | 91.42 | -5.626 | -0.9155 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3767 | 1.121 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8308 | 0.6865 | 1.619 | 0.9483 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16547</span> | 91.42 | 0.003605 | 0.2859 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008994 | 0.5931 | 1.121 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8308 | 0.6865 | 1.619 | 0.9483 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6830 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.367 | 0.6482 | -0.1602 | -0.03907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2347 | -0.2874 | 1.147 | 1.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4142 | -2.141 | 1.081 | -0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2414 | -0.4049 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 479.16316 | 1.004 | -1.426 | -0.9389 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1748 | -0.9208 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7401 | -1.113 | -0.4996 | -0.8794 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04264 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.16316 | 91.36 | -5.626 | -0.9154 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.711 | 0.3768 | 1.120 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8310 | 0.6872 | 1.618 | 0.9484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.16316</span> | 91.36 | 0.003603 | 0.2859 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008992 | 0.5931 | 1.120 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8310 | 0.6872 | 1.618 | 0.9484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.810 | 0.6431 | -0.2376 | -0.02872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2384 | -0.2689 | 1.073 | 1.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4195 | -2.179 | 2.025 | -0.6985 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1403 | -0.3873 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 479.15976 | 1.005 | -1.427 | -0.9385 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1751 | -0.9208 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7399 | -1.112 | -0.5000 | -0.8792 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04242 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.15976 | 91.41 | -5.627 | -0.9150 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3768 | 1.120 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8311 | 0.6876 | 1.618 | 0.9486 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15976</span> | 91.41 | 0.003601 | 0.2860 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008990 | 0.5931 | 1.120 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8311 | 0.6876 | 1.618 | 0.9486 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.385 | 0.6444 | -0.1513 | -0.03575 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2363 | -0.2788 | 1.057 | 1.037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4304 | -2.135 | 1.940 | -0.6607 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1552 | -0.4034 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 479.15697 | 1.004 | -1.427 | -0.9385 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1754 | -0.9212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7397 | -1.111 | -0.5007 | -0.8790 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.15697 | 91.37 | -5.627 | -0.9150 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3769 | 1.120 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8312 | 0.6883 | 1.617 | 0.9488 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15697</span> | 91.37 | 0.003600 | 0.2860 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008990 | 0.5931 | 1.120 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8312 | 0.6883 | 1.617 | 0.9488 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6829 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.828 | 0.6406 | -0.2090 | -0.02895 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2376 | -0.2659 | 1.059 | 0.9695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4112 | -2.078 | 1.041 | -0.1304 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2608 | -0.3859 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 479.15524 | 1.005 | -1.427 | -0.9384 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.099 | -1.063 | -0.1758 | -0.9215 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7396 | -1.111 | -0.5010 | -0.8789 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.15524 | 91.45 | -5.627 | -0.9149 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3769 | 1.120 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8313 | 0.6888 | 1.617 | 0.9489 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15524</span> | 91.45 | 0.003599 | 0.2860 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008989 | 0.5931 | 1.120 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8313 | 0.6888 | 1.617 | 0.9489 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.215 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.191 | 0.6447 | -0.1017 | -0.04048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2348 | -0.2858 | 1.095 | 1.009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3975 | -1.983 | 1.956 | -0.5702 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1591 | -0.3996 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 479.15192 | 1.004 | -1.428 | -0.9381 | -0.9186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.063 | -0.1760 | -0.9214 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7393 | -1.110 | -0.5013 | -0.8787 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04194 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.15192 | 91.38 | -5.628 | -0.9146 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3770 | 1.120 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8315 | 0.6892 | 1.616 | 0.9490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.15192</span> | 91.38 | 0.003597 | 0.2861 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008987 | 0.5932 | 1.120 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8315 | 0.6892 | 1.616 | 0.9490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6828 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.012 | 0.6390 | -0.1711 | -0.03027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2366 | -0.2653 | 1.098 | 0.9640 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4101 | -2.024 | 0.9749 | -0.1142 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2645 | -0.3871 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 479.14897 | 1.005 | -1.428 | -0.9380 | -0.9186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.063 | -0.1764 | -0.9218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7392 | -1.110 | -0.5017 | -0.8787 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04178 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.14897 | 91.42 | -5.628 | -0.9146 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3771 | 1.120 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8317 | 0.6900 | 1.616 | 0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14897</span> | 91.42 | 0.003596 | 0.2861 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008986 | 0.5932 | 1.120 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8317 | 0.6900 | 1.616 | 0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 479.14773 | 1.005 | -1.428 | -0.9379 | -0.9186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.062 | -0.1770 | -0.9223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7390 | -1.109 | -0.5022 | -0.8786 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04159 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.14773 | 91.47 | -5.628 | -0.9145 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.712 | 0.3771 | 1.120 | 0.05708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8318 | 0.6909 | 1.615 | 0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14773</span> | 91.47 | 0.003595 | 0.2861 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008985 | 0.5932 | 1.120 | 0.05708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8318 | 0.6909 | 1.615 | 0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.333 | 0.6414 | -0.06030 | -0.04156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2338 | -0.2836 | 1.014 | 1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3897 | -1.922 | 0.8816 | -0.1288 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1940 | -0.4011 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 479.14119 | 1.004 | -1.430 | -0.9374 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.100 | -1.062 | -0.1775 | -0.9218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7383 | -1.108 | -0.5019 | -0.8783 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04112 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.14119 | 91.39 | -5.630 | -0.9140 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.713 | 0.3774 | 1.119 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8323 | 0.6917 | 1.616 | 0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.14119</span> | 91.39 | 0.003588 | 0.2862 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008979 | 0.5933 | 1.119 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8323 | 0.6917 | 1.616 | 0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6826 | 2.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4299 | 0.6321 | -0.1435 | -0.02760 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2360 | -0.2479 | 1.019 | 0.9518 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3967 | -1.860 | 1.900 | -0.5922 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1599 | -0.3806 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 479.13501 | 1.005 | -1.431 | -0.9373 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.101 | -1.062 | -0.1783 | -0.9226 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7379 | -1.106 | -0.5035 | -0.8778 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04080 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.13501 | 91.42 | -5.631 | -0.9139 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.713 | 0.3775 | 1.119 | 0.05707 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8326 | 0.6932 | 1.614 | 0.9500 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.13501</span> | 91.42 | 0.003586 | 0.2862 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008977 | 0.5933 | 1.119 | 0.05707 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8326 | 0.6932 | 1.614 | 0.9500 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6827 | 2.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.960 | 0.6324 | -0.1010 | -0.03176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2344 | -0.2516 | 0.9454 | 0.8792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3822 | -1.742 | 0.9146 | -0.04263 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2425 | -0.3771 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 479.13244 | 1.004 | -1.432 | -0.9368 | -0.9184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.101 | -1.061 | -0.1790 | -0.9224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7372 | -1.105 | -0.5036 | -0.8775 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.04025 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.13244 | 91.33 | -5.632 | -0.9135 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.714 | 0.3778 | 1.119 | 0.05708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8331 | 0.6941 | 1.614 | 0.9502 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6825 | 2.218 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.13244</span> | 91.33 | 0.003580 | 0.2863 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008971 | 0.5933 | 1.119 | 0.05708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8331 | 0.6941 | 1.614 | 0.9502 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6825 | 2.218 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.808 | 0.6219 | -0.1958 | -0.01683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2369 | -0.2179 | 0.9347 | 0.8364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3987 | -1.797 | 0.8150 | -0.05765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2618 | -0.3704 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 479.12666 | 1.004 | -1.434 | -0.9365 | -0.9183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.102 | -1.060 | -0.1796 | -0.9220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7365 | -1.104 | -0.5033 | -0.8772 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.12666 | 91.40 | -5.634 | -0.9132 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.714 | 0.3782 | 1.118 | 0.05709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8336 | 0.6951 | 1.614 | 0.9505 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.218 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.12666</span> | 91.40 | 0.003574 | 0.2863 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008965 | 0.5934 | 1.118 | 0.05709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8336 | 0.6951 | 1.614 | 0.9505 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.218 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.9955 | 0.6218 | -0.09617 | -0.02448 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2342 | -0.2176 | 0.9924 | 0.8560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3772 | -1.645 | 1.883 | -0.4422 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1320 | -0.3750 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 479.12255 | 1.004 | -1.436 | -0.9361 | -0.9182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.103 | -1.060 | -0.1805 | -0.9221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7358 | -1.103 | -0.5043 | -0.8768 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03920 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.12255 | 91.34 | -5.636 | -0.9129 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.715 | 0.3784 | 1.118 | 0.05709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 0.6962 | 1.613 | 0.9509 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.12255</span> | 91.34 | 0.003569 | 0.2864 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008960 | 0.5935 | 1.118 | 0.05709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8341 | 0.6962 | 1.613 | 0.9509 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.219 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.522 | 0.6133 | -0.1571 | -0.01492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2353 | -0.1923 | 0.9045 | 0.7846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3572 | -1.629 | 0.8508 | 0.03564 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2811 | -0.3561 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 479.11855 | 1.005 | -1.437 | -0.9356 | -0.9182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.103 | -1.059 | -0.1812 | -0.9217 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7351 | -1.102 | -0.5043 | -0.8766 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03859 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.11855 | 91.41 | -5.637 | -0.9124 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.716 | 0.3787 | 1.118 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 0.6968 | 1.613 | 0.9510 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11855</span> | 91.41 | 0.003562 | 0.2865 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008953 | 0.5936 | 1.118 | 0.05710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8346 | 0.6968 | 1.613 | 0.9510 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.813 | 0.6131 | -0.03713 | -0.02450 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2319 | -0.1976 | 0.8863 | 0.8390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3589 | -1.516 | 0.8806 | -0.4426 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1647 | -0.3784 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 479.11487 | 1.004 | -1.439 | -0.9352 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.104 | -1.058 | -0.1819 | -0.9213 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7344 | -1.101 | -0.5040 | -0.8763 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03810 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.11487 | 91.37 | -5.639 | -0.9121 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.716 | 0.3790 | 1.117 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8352 | 0.6977 | 1.613 | 0.9514 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11487</span> | 91.37 | 0.003555 | 0.2866 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008947 | 0.5936 | 1.117 | 0.05711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8352 | 0.6977 | 1.613 | 0.9514 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.220 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.684 | 0.6054 | -0.08346 | -0.01559 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2328 | -0.1708 | 0.9518 | 0.8099 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3621 | -1.485 | 0.9267 | -0.3776 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1041 | -0.3537 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 479.11139 | 1.005 | -1.441 | -0.9347 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.105 | -1.058 | -0.1829 | -0.9211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7337 | -1.100 | -0.5039 | -0.8760 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.083 | -0.03771 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.11139 | 91.41 | -5.641 | -0.9117 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.717 | 0.3792 | 1.117 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8357 | 0.6988 | 1.613 | 0.9517 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.221 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.11139</span> | 91.41 | 0.003549 | 0.2867 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008941 | 0.5937 | 1.117 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8357 | 0.6988 | 1.613 | 0.9517 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6824 | 2.221 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.241 | 0.6036 | 0.0009951 | -0.02154 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2300 | -0.1727 | 0.8524 | 0.8311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3642 | -1.386 | 1.866 | -0.3472 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1024 | -0.3634 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 479.10851 | 1.004 | -1.443 | -0.9342 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.105 | -1.058 | -0.1837 | -0.9207 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7329 | -1.100 | -0.5043 | -0.8759 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03710 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.10851 | 91.37 | -5.643 | -0.9112 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.718 | 0.3794 | 1.117 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.6988 | 1.613 | 0.9517 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.222 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10851</span> | 91.37 | 0.003542 | 0.2868 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008933 | 0.5937 | 1.117 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.6988 | 1.613 | 0.9517 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6823 | 2.222 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.500 | 0.5956 | -0.03344 | -0.01385 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2306 | -0.1498 | 0.8910 | 0.8240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3570 | -1.405 | 0.8461 | -0.3572 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.08808 | -0.3487 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 479.10606 | 1.005 | -1.445 | -0.9338 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.106 | -1.057 | -0.1846 | -0.9207 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7320 | -1.099 | -0.5047 | -0.8757 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03650 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.10606 | 91.43 | -5.645 | -0.9108 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.719 | 0.3796 | 1.116 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8369 | 0.6994 | 1.612 | 0.9519 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6822 | 2.222 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10606</span> | 91.43 | 0.003535 | 0.2868 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008927 | 0.5938 | 1.116 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8369 | 0.6994 | 1.612 | 0.9519 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6822 | 2.222 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.260 | 0.5953 | 0.07226 | -0.02302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2275 | -0.1573 | 0.8150 | 0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3410 | -1.340 | 0.8208 | 0.1422 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2750 | -0.3500 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 479.10199 | 1.004 | -1.447 | -0.9337 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.107 | -1.057 | -0.1854 | -0.9204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7311 | -1.099 | -0.5045 | -0.8757 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03604 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.10199 | 91.37 | -5.647 | -0.9107 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.720 | 0.3799 | 1.116 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8375 | 0.6999 | 1.613 | 0.9520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6821 | 2.223 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.10199</span> | 91.37 | 0.003528 | 0.2869 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008919 | 0.5938 | 1.116 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8375 | 0.6999 | 1.613 | 0.9520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6821 | 2.223 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7698 | 0.5858 | -0.004343 | -0.01418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2278 | -0.1298 | 0.8244 | 0.7686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3575 | -1.372 | 0.8320 | -0.3359 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2977 | -0.3384 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 479.09844 | 1.005 | -1.448 | -0.9337 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.108 | -1.056 | -0.1863 | -0.9208 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7304 | -1.097 | -0.5051 | -0.8752 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.084 | -0.03534 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.09844 | 91.43 | -5.648 | -0.9108 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.720 | 0.3801 | 1.116 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8381 | 0.7011 | 1.612 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6817 | 2.224 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09844</span> | 91.43 | 0.003523 | 0.2868 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008914 | 0.5939 | 1.116 | 0.05713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8381 | 0.7011 | 1.612 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6817 | 2.224 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.894 | 0.5851 | 0.05981 | -0.02077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2261 | -0.1389 | 0.7622 | 0.7617 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3411 | -1.236 | 0.7863 | 0.1583 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2091 | -0.3951 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 479.09485 | 1.004 | -1.450 | -0.9338 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.108 | -1.056 | -0.1867 | -0.9202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7295 | -1.097 | -0.5051 | -0.8750 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03445 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.09485 | 91.37 | -5.650 | -0.9108 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.721 | 0.3803 | 1.116 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8388 | 0.7016 | 1.612 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6813 | 2.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09485</span> | 91.37 | 0.003517 | 0.2868 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008907 | 0.5939 | 1.116 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8388 | 0.7016 | 1.612 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6813 | 2.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.077 | 0.5762 | -0.02502 | -0.01122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2275 | -0.1137 | 0.7953 | 0.7347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3473 | -1.249 | 0.8683 | 0.1895 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2333 | -0.3625 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 479.09211 | 1.005 | -1.452 | -0.9337 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.109 | -1.055 | -0.1878 | -0.9202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7286 | -1.096 | -0.5055 | -0.8752 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03372 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.09211 | 91.41 | -5.652 | -0.9107 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.722 | 0.3805 | 1.115 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8394 | 0.7021 | 1.612 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.09211</span> | 91.41 | 0.003510 | 0.2868 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008900 | 0.5940 | 1.115 | 0.05714 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8394 | 0.7021 | 1.612 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.651 | 0.5754 | 0.04071 | -0.01634 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2261 | -0.1150 | 0.8084 | 0.7089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3268 | -1.156 | 0.8610 | 0.1793 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2137 | -0.3471 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 479.08947 | 1.004 | -1.454 | -0.9335 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.110 | -1.055 | -0.1890 | -0.9199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7277 | -1.096 | -0.5056 | -0.8754 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03307 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.08947 | 91.37 | -5.654 | -0.9105 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.722 | 0.3808 | 1.115 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8401 | 0.7021 | 1.611 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6809 | 2.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08947</span> | 91.37 | 0.003504 | 0.2869 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008893 | 0.5941 | 1.115 | 0.05715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8401 | 0.7021 | 1.611 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6809 | 2.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.8529 | 0.5679 | -0.006947 | -0.009666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2263 | -0.09399 | 0.7582 | 0.6848 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3382 | -1.232 | 0.7736 | -0.3452 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1950 | -0.3796 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 479.08673 | 1.005 | -1.456 | -0.9331 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.111 | -1.054 | -0.1901 | -0.9198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7269 | -1.095 | -0.5060 | -0.8751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03242 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.08673 | 91.42 | -5.656 | -0.9102 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.723 | 0.3808 | 1.114 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8406 | 0.7030 | 1.611 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.227 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08673</span> | 91.42 | 0.003498 | 0.2870 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008887 | 0.5941 | 1.114 | 0.05716 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8406 | 0.7030 | 1.611 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6810 | 2.227 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.055 | 0.5667 | 0.07240 | -0.01542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2241 | -0.1033 | 0.7160 | 0.6904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3260 | -1.123 | 0.7675 | 0.1856 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1986 | -0.4973 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 479.08385 | 1.004 | -1.457 | -0.9328 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.112 | -1.054 | -0.1908 | -0.9191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7261 | -1.095 | -0.5059 | -0.8749 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.085 | -0.03140 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.08385 | 91.37 | -5.657 | -0.9100 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.724 | 0.3808 | 1.114 | 0.05718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8412 | 0.7034 | 1.611 | 0.9527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6808 | 2.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08385</span> | 91.37 | 0.003491 | 0.2870 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008879 | 0.5941 | 1.114 | 0.05718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8412 | 0.7034 | 1.611 | 0.9527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6808 | 2.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7735 | 0.5583 | 0.01997 | -0.008335 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2243 | -0.08958 | 0.6952 | 0.6337 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3199 | -1.102 | 0.8222 | 0.2014 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2310 | -0.4538 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 479.08143 | 1.005 | -1.459 | -0.9328 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.112 | -1.054 | -0.1918 | -0.9191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7254 | -1.094 | -0.5066 | -0.8749 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.03018 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.08143 | 91.42 | -5.659 | -0.9100 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.725 | 0.3810 | 1.113 | 0.05718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8417 | 0.7042 | 1.610 | 0.9527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6804 | 2.230 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08143</span> | 91.42 | 0.003486 | 0.2870 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008874 | 0.5941 | 1.113 | 0.05718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8417 | 0.7042 | 1.610 | 0.9527 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6804 | 2.230 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.589 | 0.5568 | 0.08446 | -0.01637 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2217 | -0.09943 | 0.6530 | 0.6713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3160 | -1.044 | 0.6971 | -0.3035 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2323 | -0.3746 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 479.07858 | 1.004 | -1.461 | -0.9326 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.113 | -1.054 | -0.1923 | -0.9184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7246 | -1.093 | -0.5066 | -0.8747 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.02916 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.07858 | 91.36 | -5.661 | -0.9098 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.725 | 0.3811 | 1.113 | 0.05720 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8423 | 0.7045 | 1.610 | 0.9529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6802 | 2.231 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07858</span> | 91.36 | 0.003479 | 0.2870 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008866 | 0.5941 | 1.113 | 0.05720 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8423 | 0.7045 | 1.610 | 0.9529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6802 | 2.231 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.147 | 0.5485 | 0.01974 | -0.006990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2231 | -0.08394 | 0.6583 | 0.6424 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3232 | -1.114 | 0.8219 | 0.1886 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1911 | -0.3375 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 479.07618 | 1.004 | -1.463 | -0.9323 | -0.9182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.114 | -1.054 | -0.1929 | -0.9181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7237 | -1.093 | -0.5068 | -0.8746 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.086 | -0.02850 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.07618 | 91.40 | -5.663 | -0.9095 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.726 | 0.3811 | 1.113 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 0.7050 | 1.610 | 0.9530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6800 | 2.232 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07618</span> | 91.40 | 0.003472 | 0.2871 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008858 | 0.5941 | 1.113 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8430 | 0.7050 | 1.610 | 0.9530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6800 | 2.232 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.586 | 0.5458 | 0.07904 | -0.01251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2203 | -0.08960 | 0.6458 | 0.6586 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3031 | -0.9906 | 0.7687 | 0.2646 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1721 | -0.3284 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 479.07405 | 1.004 | -1.465 | -0.9322 | -0.9183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.115 | -1.053 | -0.1937 | -0.9179 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7228 | -1.093 | -0.5070 | -0.8747 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02798 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.07405 | 91.36 | -5.665 | -0.9094 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.727 | 0.3813 | 1.113 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8437 | 0.7050 | 1.610 | 0.9529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6797 | 2.233 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07405</span> | 91.36 | 0.003465 | 0.2871 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008850 | 0.5942 | 1.113 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8437 | 0.7050 | 1.610 | 0.9529 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6797 | 2.233 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.296 | 0.5389 | 0.03360 | -0.006173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2208 | -0.07255 | 0.6853 | 0.5995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2906 | -1.015 | 0.7685 | 0.2327 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1765 | -0.3245 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 479.07209 | 1.004 | -1.467 | -0.9321 | -0.9183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.116 | -1.053 | -0.1949 | -0.9178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7220 | -1.093 | -0.5073 | -0.8750 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02746 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.07209 | 91.39 | -5.667 | -0.9093 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.728 | 0.3814 | 1.112 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8442 | 0.7050 | 1.609 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6796 | 2.233 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07209</span> | 91.39 | 0.003458 | 0.2871 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008841 | 0.5942 | 1.112 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8442 | 0.7050 | 1.609 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6796 | 2.233 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.160 | 0.5372 | 0.08826 | -0.01153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2184 | -0.07756 | 0.6386 | 0.6404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2977 | -0.9812 | 0.7463 | 0.2047 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1647 | -0.3238 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 479.07029 | 1.004 | -1.469 | -0.9320 | -0.9184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.117 | -1.053 | -0.1960 | -0.9175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7213 | -1.093 | -0.5075 | -0.8752 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02689 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.07029 | 91.35 | -5.669 | -0.9092 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.729 | 0.3815 | 1.112 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8447 | 0.7049 | 1.609 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6795 | 2.234 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.07029</span> | 91.35 | 0.003451 | 0.2872 | 0.1130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008833 | 0.5942 | 1.112 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8447 | 0.7049 | 1.609 | 0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6795 | 2.234 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.487 | 0.5301 | 0.04502 | -0.006786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2180 | -0.06576 | 0.6433 | 0.5523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2822 | -1.039 | 1.637 | -0.2973 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2152 | -0.3175 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 479.06833 | 1.004 | -1.471 | -0.9316 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1965 | -0.9170 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7207 | -1.093 | -0.5082 | -0.8751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02616 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.06833 | 91.38 | -5.671 | -0.9088 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.730 | 0.3814 | 1.111 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8452 | 0.7048 | 1.608 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6792 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06833</span> | 91.38 | 0.003444 | 0.2872 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008825 | 0.5942 | 1.111 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8452 | 0.7048 | 1.608 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6792 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.6466 | 0.5255 | 0.09166 | -0.01288 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2142 | -0.07904 | 0.5622 | 0.5865 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2779 | -1.008 | 0.7011 | 0.1998 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.1404 | -0.3181 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 479.06868 | 1.003 | -1.472 | -0.9317 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1973 | -0.9180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7202 | -1.092 | -0.5093 | -0.8754 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02567 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.06868 | 91.29 | -5.672 | -0.9090 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.731 | 0.3814 | 1.111 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8455 | 0.7062 | 1.607 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06868</span> | 91.29 | 0.003441 | 0.2872 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008822 | 0.5942 | 1.111 | 0.05721 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8455 | 0.7062 | 1.607 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 479.06735 | 1.004 | -1.472 | -0.9316 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1969 | -0.9175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7205 | -1.092 | -0.5087 | -0.8753 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.087 | -0.02593 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.06735 | 91.33 | -5.672 | -0.9089 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.730 | 0.3814 | 1.111 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 0.7054 | 1.608 | 0.9523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6791 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06735</span> | 91.33 | 0.003443 | 0.2872 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008823 | 0.5942 | 1.111 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8453 | 0.7054 | 1.608 | 0.9523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6791 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.476 | 0.5223 | 0.03269 | -0.003763 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2173 | -0.06616 | 0.5281 | 0.5229 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3041 | -1.023 | 1.607 | -0.2773 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2325 | -0.3192 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 479.06543 | 1.004 | -1.472 | -0.9319 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.118 | -1.053 | -0.1968 | -0.9175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7201 | -1.092 | -0.5088 | -0.8751 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -0.02567 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.06543 | 91.36 | -5.672 | -0.9091 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.731 | 0.3815 | 1.111 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8456 | 0.7056 | 1.608 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.06543</span> | 91.36 | 0.003439 | 0.2872 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008820 | 0.5942 | 1.111 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8456 | 0.7056 | 1.608 | 0.9525 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6790 | 2.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 479.06390 | 1.004 | -1.474 | -0.9324 | -0.9185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.119 | -1.053 | -0.1965 | -0.9174 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7194 | -1.092 | -0.5089 | -0.8750 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.088 | -0.02528 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.0639 | 91.36 | -5.674 | -0.9095 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.732 | 0.3816 | 1.111 | 0.05723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8461 | 0.7059 | 1.607 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6786 | 2.236 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.0639</span> | 91.36 | 0.003434 | 0.2871 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008813 | 0.5943 | 1.111 | 0.05723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8461 | 0.7059 | 1.607 | 0.9526 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6786 | 2.236 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 479.05708 | 1.004 | -1.481 | -0.9346 | -0.9186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.123 | -1.051 | -0.1952 | -0.9171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7164 | -1.090 | -0.5089 | -0.8741 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.090 | -0.02338 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.05708 | 91.37 | -5.681 | -0.9115 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.735 | 0.3824 | 1.112 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8483 | 0.7072 | 1.607 | 0.9535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6769 | 2.238 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.05708</span> | 91.37 | 0.003409 | 0.2867 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008783 | 0.5944 | 1.112 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8483 | 0.7072 | 1.607 | 0.9535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6769 | 2.238 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 479.03987 | 1.004 | -1.510 | -0.9434 | -0.9188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.136 | -1.045 | -0.1899 | -0.9157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7043 | -1.085 | -0.5092 | -0.8705 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.098 | -0.01577 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.03987 | 91.37 | -5.710 | -0.9193 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.749 | 0.3852 | 1.114 | 0.05728 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8571 | 0.7123 | 1.607 | 0.9569 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6702 | 2.247 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.03987</span> | 91.37 | 0.003311 | 0.2851 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008662 | 0.5951 | 1.114 | 0.05728 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8571 | 0.7123 | 1.607 | 0.9569 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6702 | 2.247 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3651 | 0.4285 | -0.5283 | -0.001988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1991 | 0.06799 | 0.8278 | 0.7155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2362 | -0.3851 | 0.6274 | 0.1204 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.9270 | -0.3308 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 139</span>| 479.01407 | 1.005 | -1.553 | -0.9371 | -0.9187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.158 | -1.041 | -0.1978 | -0.9162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6881 | -1.086 | -0.5088 | -0.8721 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.097 | -0.01436 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.01407 | 91.44 | -5.753 | -0.9138 | -2.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.770 | 0.3869 | 1.111 | 0.05726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8690 | 0.7117 | 1.608 | 0.9554 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6704 | 2.249 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.01407</span> | 91.44 | 0.003172 | 0.2862 | 0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008479 | 0.5955 | 1.111 | 0.05726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8690 | 0.7117 | 1.608 | 0.9554 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6704 | 2.249 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.322 | 0.3385 | -0.09736 | -0.005783 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1607 | 0.1322 | 0.5556 | 0.5176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1562 | -0.2690 | 1.549 | -0.03161 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8578 | -0.3240 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 140</span>| 478.99946 | 1.003 | -1.595 | -0.9294 | -0.9194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.179 | -1.045 | -0.1992 | -0.9136 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6715 | -1.093 | -0.5132 | -0.8724 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.009543 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.99946 | 91.31 | -5.795 | -0.9069 | -2.182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.791 | 0.3851 | 1.110 | 0.05734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8811 | 0.7049 | 1.602 | 0.9551 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6678 | 2.255 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99946</span> | 91.31 | 0.003042 | 0.2876 | 0.1128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008303 | 0.5951 | 1.110 | 0.05734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8811 | 0.7049 | 1.602 | 0.9551 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6678 | 2.255 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.440 | 0.2525 | 0.1677 | 0.001517 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1272 | 0.05864 | 0.6253 | 0.4352 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1457 | -0.7321 | 1.353 | 0.0009973 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.018 | -0.3498 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 141</span>| 479.00064 | 1.004 | -1.626 | -0.9429 | -0.9240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.201 | -1.064 | -0.2165 | -0.9169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6612 | -1.100 | -0.5189 | -0.8809 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.001744 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.00064 | 91.38 | -5.826 | -0.9189 | -2.186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.814 | 0.3763 | 1.103 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8887 | 0.6986 | 1.596 | 0.9470 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6683 | 2.264 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.00064</span> | 91.38 | 0.002950 | 0.2852 | 0.1123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008117 | 0.5930 | 1.103 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8887 | 0.6986 | 1.596 | 0.9470 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6683 | 2.264 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 142</span>| 478.99385 | 1.004 | -1.610 | -0.9359 | -0.9216 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.190 | -1.054 | -0.2077 | -0.9152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6665 | -1.096 | -0.5161 | -0.8765 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.100 | -0.005738 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.99385 | 91.39 | -5.810 | -0.9127 | -2.184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.802 | 0.3808 | 1.107 | 0.05729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8848 | 0.7019 | 1.599 | 0.9512 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6681 | 2.260 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99385</span> | 91.39 | 0.002997 | 0.2864 | 0.1126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008212 | 0.5941 | 1.107 | 0.05729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8848 | 0.7019 | 1.599 | 0.9512 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6681 | 2.260 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.499 | 0.2382 | -0.03703 | -0.03958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09629 | -0.2111 | 0.3210 | 0.2393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1233 | -0.7892 | 1.126 | -0.4047 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.051 | -0.3984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 143</span>| 478.98455 | 1.004 | -1.625 | -0.9347 | -0.9200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.200 | -1.054 | -0.2131 | -0.9088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6653 | -1.094 | -0.5167 | -0.8757 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.099 | 0.008183 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.98455 | 91.36 | -5.825 | -0.9116 | -2.182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.813 | 0.3812 | 1.105 | 0.05748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8857 | 0.7042 | 1.598 | 0.9520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6689 | 2.277 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.98455</span> | 91.36 | 0.002951 | 0.2867 | 0.1128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008125 | 0.5942 | 1.105 | 0.05748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8857 | 0.7042 | 1.598 | 0.9520 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6689 | 2.277 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.2799 | 0.1926 | -0.02074 | -0.02333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08052 | -0.1468 | 0.2817 | 0.3348 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1470 | -0.6425 | 1.062 | -0.3208 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8181 | -0.3186 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 144</span>| 478.97736 | 1.005 | -1.639 | -0.9325 | -0.9174 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.210 | -1.043 | -0.2100 | -0.9166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6557 | -1.093 | -0.5206 | -0.8754 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.097 | 0.01446 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97736 | 91.42 | -5.839 | -0.9097 | -2.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.822 | 0.3861 | 1.106 | 0.05725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8927 | 0.7053 | 1.594 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6711 | 2.284 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97736</span> | 91.42 | 0.002912 | 0.2871 | 0.1131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008047 | 0.5953 | 1.106 | 0.05725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8927 | 0.7053 | 1.594 | 0.9522 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6711 | 2.284 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.719 | 0.1644 | 0.1764 | 0.0002018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06754 | 0.1935 | -0.08189 | -0.1310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08678 | -2.826 | 0.8338 | -0.2552 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4561 | -0.1956 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 145</span>| 478.97194 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.087 | -0.5238 | -0.8740 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01749 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97194 | 91.40 | -5.852 | -0.9078 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97194</span> | 91.40 | 0.002874 | 0.2875 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.925 | 0.1117 | 0.2312 | 0.02461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04286 | 0.3818 | 0.1548 | -0.1592 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04325 | -0.1382 | 0.7430 | -0.2262 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.01070 | -0.1316 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 146</span>| 479.08778 | 0.9990 | -1.662 | -0.9298 | -0.9158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.224 | -1.050 | -0.2095 | -0.9175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6325 | -1.087 | -0.5258 | -0.8715 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.094 | 0.02816 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.08778 | 90.91 | -5.862 | -0.9073 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.836 | 0.3828 | 1.106 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9096 | 0.7103 | 1.587 | 0.9559 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6733 | 2.301 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.08778</span> | 90.91 | 0.002845 | 0.2876 | 0.1132 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007936 | 0.5946 | 1.106 | 0.05722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9096 | 0.7103 | 1.587 | 0.9559 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6733 | 2.301 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 147</span>| 478.99303 | 1.002 | -1.652 | -0.9306 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2045 | -0.9253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.087 | -0.5244 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01760 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.99303 | 91.18 | -5.852 | -0.9080 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7107 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.99303</span> | 91.18 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7107 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 148</span>| 478.97158 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.087 | -0.5239 | -0.8740 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01751 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97158 | 91.37 | -5.852 | -0.9078 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97158</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7106 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.1518 | 0.1094 | 0.1916 | 0.02921 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04385 | 0.3896 | -0.2077 | -0.4379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03471 | -2.421 | 0.7262 | -0.1589 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01110 | -0.1305 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 149</span>| 478.97152 | 1.004 | -1.652 | -0.9304 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2044 | -0.9254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6443 | -1.086 | -0.5240 | -0.8739 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01753 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97152 | 91.37 | -5.852 | -0.9078 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3880 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7109 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97152</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9010 | 0.7109 | 1.590 | 0.9536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.2246 | 0.1050 | 0.1574 | 0.02036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04103 | 0.3470 | -0.3387 | -0.1919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1172 | -0.1870 | 0.6243 | -0.2341 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.06769 | -0.1265 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 150</span>| 478.97142 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2042 | -0.9253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5242 | -0.8739 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01757 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97142 | 91.38 | -5.852 | -0.9079 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97142</span> | 91.38 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.5593 | 0.1052 | 0.1640 | 0.01900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04052 | 0.3419 | -0.3227 | -0.1646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1158 | -0.1768 | 0.1839 | -0.2151 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04116 | -0.1006 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 151</span>| 478.97143 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5243 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01761 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97143 | 91.36 | -5.852 | -0.9079 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97143</span> | 91.36 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 152</span>| 478.97137 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2042 | -0.9253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6442 | -1.086 | -0.5242 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01759 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97137 | 91.37 | -5.852 | -0.9079 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97137</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9011 | 0.7110 | 1.589 | 0.9537 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.4660 | 0.1043 | 0.1497 | 0.02048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04080 | 0.3434 | -0.3050 | -0.1804 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2015 | -1.954 | 0.1460 | -0.2263 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03239 | -0.1147 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 153</span>| 478.97135 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -1.086 | -0.5242 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01760 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97135 | 91.36 | -5.852 | -0.9079 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7110 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97135</span> | 91.36 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7110 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.8144 | 0.1038 | 0.1446 | 0.02101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04083 | 0.3431 | -0.3133 | -0.1844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05440 | -1.096 | 0.1463 | -0.2004 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.2780 | -0.1269 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 154</span>| 478.97125 | 1.004 | -1.652 | -0.9305 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2041 | -0.9252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6441 | -1.086 | -0.5243 | -0.8738 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01762 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97125 | 91.37 | -5.852 | -0.9079 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3879 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7111 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97125</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7111 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | 0.03985 | 0.1039 | 0.1540 | 0.01970 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04056 | 0.3392 | -0.3415 | -0.1666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1386 | -0.1574 | 0.08901 | -0.2003 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04000 | -0.1187 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 155</span>| 478.97118 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2040 | -0.9252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6440 | -1.086 | -0.5243 | -0.8737 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01765 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97118 | 91.37 | -5.852 | -0.9080 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3878 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97118</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -0.05720 | 0.1036 | 0.1507 | 0.01972 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04048 | 0.3375 | -0.2940 | -0.1684 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1979 | -1.920 | 0.1339 | -0.2027 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.04399 | -0.1216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 156</span>| 478.97118 | 1.004 | -1.652 | -0.9306 | -0.9153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.221 | -1.039 | -0.2040 | -0.9252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6440 | -1.086 | -0.5243 | -0.8737 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.092 | 0.01765 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.97118 | 91.37 | -5.852 | -0.9080 | -2.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.833 | 0.3878 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.97118</span> | 91.37 | 0.002874 | 0.2874 | 0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.007961 | 0.5958 | 1.108 | 0.05700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9012 | 0.7112 | 1.589 | 0.9538 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.6749 | 2.288 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># Two-component error by variable is possible with both estimation methods</span></span> -<span class="r-in"><span class="co"># Variance by variable is supported by 'saem' and 'focei'</span></span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_saem_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> 1: 92.0624 -5.2854 0.1952 1.9494 -1.9431 2.8500 1.6150 0.7315 0.7220 0.4370 6.8425 0.4265 7.3797 0.5659</span> -<span class="r-out co"><span class="r-pr">#></span> 2: 92.7371 -5.3819 0.0345 2.0839 -2.0310 2.7075 1.5342 0.6949 0.8358 0.4151 7.2043 0.0003 8.1096 0.0003</span> -<span class="r-out co"><span class="r-pr">#></span> 3: 9.2941e+01 -5.7880e+00 1.0336e-01 2.5772e+00 -1.5152e+00 2.5721e+00 1.4575e+00 6.6018e-01 7.9403e-01 3.9439e-01 4.5749e+00 1.5986e-05 5.1354e+00 2.8796e-05</span> -<span class="r-out co"><span class="r-pr">#></span> 4: 92.6277 -5.8599 0.0858 2.5068 -1.3253 2.4435 1.3847 0.6272 0.7543 0.3747 3.4165 0.0001 3.9071 0.0016</span> -<span class="r-out co"><span class="r-pr">#></span> 5: 93.0289 -6.0258 0.0528 2.4932 -1.1961 2.3213 1.3154 0.5958 0.7166 0.3559 3.2552 0.0069 3.3744 0.0170</span> -<span class="r-out co"><span class="r-pr">#></span> 6: 93.2107 -6.2881 0.0143 2.4052 -1.1930 2.2053 2.2853 0.5660 0.6808 0.3381 2.8020 0.0086 3.1436 0.0256</span> -<span class="r-out co"><span class="r-pr">#></span> 7: 93.0563 -6.3624 -0.0104 2.3989 -1.1521 2.0950 2.4414 0.5377 0.6467 0.3212 2.6528 0.0209 2.8462 0.0289</span> -<span class="r-out co"><span class="r-pr">#></span> 8: 93.0567 -6.2699 -0.0303 2.3700 -1.0941 1.9903 2.5004 0.5204 0.6144 0.3052 2.3448 0.0314 2.5026 0.0349</span> -<span class="r-out co"><span class="r-pr">#></span> 9: 92.8366 -6.2013 -0.0507 2.3798 -1.0963 1.8907 2.6552 0.4943 0.5837 0.2899 2.2219 0.0368 2.2604 0.0448</span> -<span class="r-out co"><span class="r-pr">#></span> 10: 92.9069 -6.2499 -0.1116 2.3100 -1.0557 1.9625 3.9231 0.4696 0.5545 0.2754 2.0980 0.0359 2.1413 0.0325</span> -<span class="r-out co"><span class="r-pr">#></span> 11: 92.9942 -6.2134 -0.1037 2.3109 -1.0441 1.8643 3.7270 0.4755 0.5268 0.2616 1.9711 0.0372 1.9901 0.0355</span> -<span class="r-out co"><span class="r-pr">#></span> 12: 92.9262 -6.2511 -0.1133 2.2707 -1.0465 1.8430 4.3304 0.4697 0.5004 0.2486 1.8083 0.0346 1.9184 0.0356</span> -<span class="r-out co"><span class="r-pr">#></span> 13: 93.0761 -6.3559 -0.1106 2.2534 -1.0162 2.4826 5.2857 0.4685 0.4754 0.2361 1.7896 0.0331 1.9865 0.0342</span> -<span class="r-out co"><span class="r-pr">#></span> 14: 93.0929 -6.1852 -0.1058 2.2972 -1.0175 2.9964 5.0214 0.4451 0.4516 0.2243 1.8316 0.0309 1.9112 0.0348</span> -<span class="r-out co"><span class="r-pr">#></span> 15: 93.3343 -6.3408 -0.1025 2.2905 -0.9962 3.1132 4.9630 0.4594 0.4291 0.2131 1.8198 0.0338 1.9154 0.0372</span> -<span class="r-out co"><span class="r-pr">#></span> 16: 92.9959 -6.2227 -0.1016 2.2869 -1.0103 3.3338 4.7149 0.4598 0.4076 0.2025 1.8726 0.0327 1.9617 0.0361</span> -<span class="r-out co"><span class="r-pr">#></span> 17: 93.0394 -6.2586 -0.1027 2.2932 -0.9991 3.1671 4.8730 0.4591 0.3872 0.1923 1.8405 0.0336 2.0192 0.0242</span> -<span class="r-out co"><span class="r-pr">#></span> 18: 93.2374 -6.3410 -0.1110 2.2965 -0.9689 3.0087 5.4325 0.4632 0.3679 0.1827 1.9051 0.0351 1.9247 0.0277</span> -<span class="r-out co"><span class="r-pr">#></span> 19: 93.0557 -6.4503 -0.1011 2.2941 -0.9884 2.8583 6.2872 0.4742 0.3495 0.1736 1.8054 0.0345 1.9173 0.0260</span> -<span class="r-out co"><span class="r-pr">#></span> 20: 92.9280 -6.4945 -0.1018 2.2902 -0.9864 3.5934 6.8737 0.4751 0.3320 0.1649 1.7097 0.0372 1.9483 0.0225</span> -<span class="r-out co"><span class="r-pr">#></span> 21: 93.2023 -6.3418 -0.1033 2.2846 -0.9863 3.4138 6.5300 0.4710 0.3154 0.1567 1.7507 0.0318 1.9030 0.0249</span> -<span class="r-out co"><span class="r-pr">#></span> 22: 93.5494 -6.1985 -0.1078 2.2991 -1.0171 3.2431 6.2035 0.4475 0.2996 0.1488 1.7370 0.0342 1.8124 0.0282</span> -<span class="r-out co"><span class="r-pr">#></span> 23: 93.3588 -6.2577 -0.1084 2.2654 -0.9956 3.0809 5.8933 0.4393 0.2869 0.1481 1.6928 0.0380 1.8288 0.0254</span> -<span class="r-out co"><span class="r-pr">#></span> 24: 93.5705 -6.4876 -0.1083 2.2606 -1.0062 3.7095 6.7801 0.4459 0.2726 0.1684 1.7001 0.0377 1.9012 0.0249</span> -<span class="r-out co"><span class="r-pr">#></span> 25: 93.9726 -6.5638 -0.1239 2.2374 -1.0071 5.1357 6.6571 0.4608 0.2755 0.1600 1.6615 0.0382 1.8846 0.0213</span> -<span class="r-out co"><span class="r-pr">#></span> 26: 93.8894 -6.5073 -0.1120 2.2645 -1.0327 4.8789 6.3243 0.4473 0.3014 0.1520 1.7152 0.0340 1.8990 0.0254</span> -<span class="r-out co"><span class="r-pr">#></span> 27: 94.5348 -6.3868 -0.0891 2.3139 -1.0361 5.3856 6.0081 0.4250 0.3080 0.1453 1.7028 0.0385 1.7853 0.0304</span> -<span class="r-out co"><span class="r-pr">#></span> 28: 93.9221 -6.1747 -0.1039 2.3013 -1.0087 5.1163 5.7077 0.4214 0.3136 0.1634 1.6823 0.0340 1.7487 0.0353</span> -<span class="r-out co"><span class="r-pr">#></span> 29: 93.4946 -6.0264 -0.0940 2.3124 -1.0166 5.3744 5.4223 0.4404 0.3114 0.1813 1.6310 0.0370 1.7646 0.0367</span> -<span class="r-out co"><span class="r-pr">#></span> 30: 93.9287 -5.9114 -0.0967 2.3078 -1.0090 5.2017 5.1512 0.4381 0.3048 0.2091 1.5825 0.0393 1.7431 0.0312</span> -<span class="r-out co"><span class="r-pr">#></span> 31: 93.7065 -6.0174 -0.0928 2.2917 -0.9880 5.1935 4.8936 0.4352 0.3109 0.1986 1.5876 0.0392 1.8465 0.0280</span> -<span class="r-out co"><span class="r-pr">#></span> 32: 93.7675 -5.6444 -0.0918 2.3145 -0.9664 4.9338 4.6489 0.4332 0.3090 0.1918 1.6874 0.0332 1.7501 0.0331</span> -<span class="r-out co"><span class="r-pr">#></span> 33: 94.2589 -5.7637 -0.0865 2.3130 -0.9733 4.6871 4.4165 0.4235 0.2935 0.1865 1.7173 0.0355 1.7365 0.0334</span> -<span class="r-out co"><span class="r-pr">#></span> 34: 94.0788 -5.7432 -0.1022 2.3049 -0.9681 4.4528 4.1957 0.4319 0.2962 0.1772 1.6357 0.0361 1.4755 0.0574</span> -<span class="r-out co"><span class="r-pr">#></span> 35: 94.0798 -5.8549 -0.0929 2.2856 -0.9849 4.2301 3.9859 0.4391 0.2937 0.1734 1.6460 0.0275 1.7739 0.0379</span> -<span class="r-out co"><span class="r-pr">#></span> 36: 93.9997 -5.8708 -0.0890 2.2870 -1.0134 4.0186 3.7866 0.4268 0.2819 0.1840 1.5830 0.0258 1.8922 0.0320</span> -<span class="r-out co"><span class="r-pr">#></span> 37: 93.8186 -5.8979 -0.0973 2.2807 -1.0197 3.8177 3.5973 0.4280 0.2778 0.1799 1.5783 0.0282 1.7697 0.0404</span> -<span class="r-out co"><span class="r-pr">#></span> 38: 94.0728 -5.9601 -0.0936 2.3011 -1.0381 3.6268 3.4174 0.4186 0.2944 0.1864 1.5780 0.0294 1.5210 0.0558</span> -<span class="r-out co"><span class="r-pr">#></span> 39: 94.0504 -5.8302 -0.0995 2.2847 -1.0418 3.4455 3.2465 0.4240 0.2796 0.1771 1.6888 0.0242 1.7744 0.0366</span> -<span class="r-out co"><span class="r-pr">#></span> 40: 93.8918 -5.9418 -0.0988 2.2925 -1.0613 3.2732 3.0842 0.4144 0.2672 0.1837 1.7275 0.0232 1.7840 0.0357</span> -<span class="r-out co"><span class="r-pr">#></span> 41: 93.7961 -6.0741 -0.0896 2.2932 -1.0359 3.1095 3.2890 0.4236 0.2606 0.1782 1.7591 0.0212 1.8920 0.0273</span> -<span class="r-out co"><span class="r-pr">#></span> 42: 93.9458 -6.0319 -0.0909 2.3114 -1.0281 3.0544 3.1246 0.4196 0.2598 0.1839 1.6854 0.0310 1.7586 0.0308</span> -<span class="r-out co"><span class="r-pr">#></span> 43: 93.7623 -6.0165 -0.1056 2.2837 -1.0378 3.9092 3.2100 0.4298 0.2468 0.1747 1.7064 0.0286 1.6676 0.0397</span> -<span class="r-out co"><span class="r-pr">#></span> 44: 93.4300 -5.9019 -0.1114 2.2716 -1.0167 4.4100 3.0495 0.4476 0.2345 0.1687 1.7989 0.0253 1.7741 0.0299</span> -<span class="r-out co"><span class="r-pr">#></span> 45: 93.3475 -5.9962 -0.1231 2.2546 -1.0007 6.4879 3.3965 0.4528 0.2452 0.1602 1.7283 0.0276 1.7219 0.0379</span> -<span class="r-out co"><span class="r-pr">#></span> 46: 93.3100 -6.0073 -0.1255 2.2483 -0.9962 6.6009 3.5942 0.4520 0.2533 0.1568 1.6991 0.0258 1.1783 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 47: 93.4422 -5.8442 -0.1286 2.2578 -0.9819 6.2709 3.4145 0.4492 0.2637 0.1694 1.6754 0.0317 1.3442 0.0599</span> -<span class="r-out co"><span class="r-pr">#></span> 48: 93.0996 -5.5881 -0.1307 2.2541 -0.9882 5.9573 3.2438 0.4480 0.2665 0.1695 1.7040 0.0285 1.6825 0.0426</span> -<span class="r-out co"><span class="r-pr">#></span> 49: 93.3649 -5.8011 -0.1260 2.2595 -0.9704 5.7230 3.0816 0.4399 0.2646 0.1715 1.6544 0.0297 1.6414 0.0418</span> -<span class="r-out co"><span class="r-pr">#></span> 50: 93.9331 -5.8731 -0.1195 2.2615 -0.9837 5.4368 2.9275 0.4453 0.2735 0.1940 1.6316 0.0289 1.6885 0.0392</span> -<span class="r-out co"><span class="r-pr">#></span> 51: 93.6092 -5.8721 -0.1237 2.2599 -1.0015 5.1650 2.7811 0.4413 0.2865 0.1939 1.6492 0.0272 1.7686 0.0358</span> -<span class="r-out co"><span class="r-pr">#></span> 52: 93.3008 -5.9775 -0.1277 2.2628 -0.9962 4.9067 3.1139 0.4438 0.2946 0.1963 1.5642 0.0337 1.7391 0.0335</span> -<span class="r-out co"><span class="r-pr">#></span> 53: 93.6347 -6.0805 -0.1189 2.2663 -1.0177 4.6614 3.5169 0.4335 0.2962 0.2043 1.5275 0.0343 1.7417 0.0366</span> -<span class="r-out co"><span class="r-pr">#></span> 54: 93.5781 -6.0412 -0.1166 2.2573 -1.0015 4.4283 3.3411 0.4395 0.2912 0.2080 1.5464 0.0346 1.7584 0.0359</span> -<span class="r-out co"><span class="r-pr">#></span> 55: 93.9675 -6.0867 -0.0952 2.2970 -0.9987 4.2069 3.6762 0.4550 0.2780 0.1988 1.5138 0.0405 1.6251 0.0472</span> -<span class="r-out co"><span class="r-pr">#></span> 56: 94.4069 -6.1375 -0.0943 2.2975 -1.0190 3.9966 4.2280 0.4550 0.2806 0.1945 1.5294 0.0425 1.6443 0.0468</span> -<span class="r-out co"><span class="r-pr">#></span> 57: 93.8076 -6.1618 -0.0936 2.2687 -1.0237 3.7967 4.3085 0.4524 0.2666 0.1897 1.5227 0.0414 1.6955 0.0438</span> -<span class="r-out co"><span class="r-pr">#></span> 58: 93.9188 -6.2272 -0.0947 2.2767 -1.0408 3.6069 4.6707 0.4536 0.2676 0.1873 1.5201 0.0425 1.5336 0.0550</span> -<span class="r-out co"><span class="r-pr">#></span> 59: 93.9572 -6.3460 -0.1074 2.2746 -1.0069 3.4266 5.8058 0.4614 0.2718 0.1919 1.5533 0.0417 1.6227 0.0460</span> -<span class="r-out co"><span class="r-pr">#></span> 60: 93.5430 -6.1622 -0.1048 2.2861 -0.9959 3.2552 5.5155 0.4535 0.2848 0.1823 1.4745 0.0431 1.5242 0.0522</span> -<span class="r-out co"><span class="r-pr">#></span> 61: 93.8016 -6.4079 -0.1065 2.2897 -1.0325 3.0925 5.9252 0.4583 0.2901 0.1732 1.5364 0.0365 1.4623 0.0550</span> -<span class="r-out co"><span class="r-pr">#></span> 62: 93.4249 -6.2284 -0.0967 2.3126 -1.0208 2.9378 5.6289 0.4429 0.2756 0.1645 1.6111 0.0325 1.3996 0.0618</span> -<span class="r-out co"><span class="r-pr">#></span> 63: 93.2335 -6.0996 -0.1051 2.3047 -0.9976 2.7909 5.3475 0.4292 0.2719 0.1633 1.6010 0.0326 1.5115 0.0494</span> -<span class="r-out co"><span class="r-pr">#></span> 64: 92.7091 -6.1109 -0.1041 2.3032 -0.9746 3.2610 5.0801 0.4301 0.2793 0.1751 1.5979 0.0302 1.3867 0.0575</span> -<span class="r-out co"><span class="r-pr">#></span> 65: 92.6059 -6.0049 -0.1077 2.3062 -0.9853 3.0979 4.8261 0.4316 0.2826 0.1714 1.6357 0.0272 1.3931 0.0543</span> -<span class="r-out co"><span class="r-pr">#></span> 66: 92.7778 -6.0856 -0.1040 2.3057 -0.9828 2.9430 4.5848 0.4362 0.2888 0.1628 1.6126 0.0316 1.4340 0.0505</span> -<span class="r-out co"><span class="r-pr">#></span> 67: 93.0325 -6.1775 -0.1085 2.3122 -0.9714 2.7959 4.3790 0.4464 0.2843 0.1547 1.6090 0.0354 1.4966 0.0448</span> -<span class="r-out co"><span class="r-pr">#></span> 68: 92.8987 -5.8741 -0.1089 2.3184 -0.9567 2.6561 4.1601 0.4389 0.2866 0.1470 1.5888 0.0347 1.4492 0.0507</span> -<span class="r-out co"><span class="r-pr">#></span> 69: 92.7300 -6.0473 -0.1070 2.3082 -0.9739 2.5233 4.0183 0.4371 0.3158 0.1527 1.5904 0.0298 1.5387 0.0477</span> -<span class="r-out co"><span class="r-pr">#></span> 70: 92.5285 -6.0962 -0.1115 2.3179 -0.9785 2.4856 4.0612 0.4380 0.3059 0.1504 1.5237 0.0402 1.4541 0.0463</span> -<span class="r-out co"><span class="r-pr">#></span> 71: 92.3975 -6.2090 -0.1269 2.2819 -0.9713 2.3613 4.3811 0.4173 0.2906 0.1520 1.5388 0.0316 1.3713 0.0584</span> -<span class="r-out co"><span class="r-pr">#></span> 72: 92.1593 -6.2214 -0.1217 2.2950 -0.9481 2.2433 5.1205 0.4227 0.2760 0.1605 1.5431 0.0312 1.5797 0.0459</span> -<span class="r-out co"><span class="r-pr">#></span> 73: 92.1195 -6.6667 -0.1244 2.3076 -0.9642 2.1311 7.6538 0.4124 0.2622 0.1525 1.4505 0.0375 1.2810 0.0595</span> -<span class="r-out co"><span class="r-pr">#></span> 74: 92.2191 -6.6665 -0.1278 2.2989 -0.9703 2.0246 7.2711 0.4098 0.2491 0.1666 1.4309 0.0384 1.2717 0.0638</span> -<span class="r-out co"><span class="r-pr">#></span> 75: 92.4656 -6.8881 -0.1274 2.3011 -0.9595 1.9233 8.3835 0.4147 0.2367 0.1656 1.4181 0.0424 1.2498 0.0620</span> -<span class="r-out co"><span class="r-pr">#></span> 76: 92.4593 -6.2323 -0.1203 2.2912 -0.9799 1.8272 7.9643 0.3967 0.2301 0.1596 1.5448 0.0336 1.6758 0.0359</span> -<span class="r-out co"><span class="r-pr">#></span> 77: 92.4501 -6.1123 -0.1219 2.2889 -0.9426 1.7358 7.5661 0.4049 0.2299 0.1594 1.5380 0.0327 1.6947 0.0364</span> -<span class="r-out co"><span class="r-pr">#></span> 78: 92.5059 -6.0339 -0.1198 2.2985 -0.9544 1.6490 7.1878 0.4007 0.2422 0.1568 1.5722 0.0302 1.5665 0.0415</span> -<span class="r-out co"><span class="r-pr">#></span> 79: 92.4302 -6.6428 -0.1141 2.3119 -0.9421 1.5666 9.0889 0.3986 0.2340 0.1489 1.5029 0.0306 1.1894 0.0638</span> -<span class="r-out co"><span class="r-pr">#></span> 80: 92.5305 -6.3036 -0.1127 2.3099 -0.9406 1.9062 8.6344 0.4091 0.2327 0.1648 1.5558 0.0308 1.0136 0.0749</span> -<span class="r-out co"><span class="r-pr">#></span> 81: 92.6652 -6.0832 -0.1167 2.2994 -0.9552 2.3641 8.2027 0.4142 0.2348 0.1566 1.6232 0.0300 1.1320 0.0712</span> -<span class="r-out co"><span class="r-pr">#></span> 82: 92.5109 -6.1524 -0.1100 2.3037 -0.9686 2.2459 7.7926 0.4145 0.2381 0.1695 1.6128 0.0306 1.6145 0.0413</span> -<span class="r-out co"><span class="r-pr">#></span> 83: 92.6455 -6.3979 -0.1059 2.3245 -0.9573 2.1336 8.1077 0.4060 0.2348 0.1667 1.6039 0.0304 1.6251 0.0419</span> -<span class="r-out co"><span class="r-pr">#></span> 84: 92.5768 -6.3469 -0.0979 2.3177 -0.9346 2.0269 8.2125 0.4141 0.2439 0.1720 1.6334 0.0302 1.5803 0.0450</span> -<span class="r-out co"><span class="r-pr">#></span> 85: 92.7920 -6.3536 -0.0969 2.3363 -0.9389 1.9256 8.1820 0.4035 0.2512 0.1713 1.5815 0.0338 1.1193 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 86: 92.8571 -6.2567 -0.0911 2.3426 -0.9633 1.8293 8.1211 0.4008 0.2659 0.1627 1.5840 0.0356 1.2425 0.0639</span> -<span class="r-out co"><span class="r-pr">#></span> 87: 92.9101 -6.1557 -0.0937 2.3326 -0.9624 1.7378 7.7151 0.3950 0.2839 0.1546 1.6017 0.0354 1.0600 0.0766</span> -<span class="r-out co"><span class="r-pr">#></span> 88: 92.7649 -6.2151 -0.0881 2.3275 -0.9967 1.6509 7.3293 0.4046 0.2697 0.1469 1.6092 0.0302 1.1839 0.0693</span> -<span class="r-out co"><span class="r-pr">#></span> 89: 92.9350 -5.9222 -0.0903 2.3372 -0.9612 1.5684 6.9628 0.4058 0.2818 0.1395 1.5957 0.0335 1.5450 0.0444</span> -<span class="r-out co"><span class="r-pr">#></span> 90: 92.7895 -5.9348 -0.0890 2.3457 -0.9601 1.4900 6.6147 0.4070 0.2705 0.1430 1.5716 0.0378 1.4918 0.0439</span> -<span class="r-out co"><span class="r-pr">#></span> 91: 93.0113 -5.9302 -0.0997 2.3316 -0.9489 1.4155 6.2840 0.4424 0.2929 0.1410 1.5582 0.0377 1.2459 0.0582</span> -<span class="r-out co"><span class="r-pr">#></span> 92: 92.8603 -6.3366 -0.0918 2.3356 -0.9938 1.3447 5.9698 0.4287 0.2929 0.1531 1.4906 0.0398 1.2421 0.0605</span> -<span class="r-out co"><span class="r-pr">#></span> 93: 92.8094 -6.1097 -0.0953 2.3382 -0.9996 1.2775 5.6713 0.4309 0.2783 0.1597 1.4317 0.0468 1.2694 0.0584</span> -<span class="r-out co"><span class="r-pr">#></span> 94: 92.7100 -6.1043 -0.0909 2.3287 -0.9928 1.3828 5.3877 0.4337 0.2698 0.1517 1.4173 0.0489 1.4335 0.0476</span> -<span class="r-out co"><span class="r-pr">#></span> 95: 92.2055 -6.1792 -0.0889 2.3553 -0.9983 1.3137 5.1183 0.4209 0.3273 0.1566 1.4865 0.0417 1.2485 0.0681</span> -<span class="r-out co"><span class="r-pr">#></span> 96: 92.3225 -6.2710 -0.0811 2.3734 -1.0043 1.3428 4.8624 0.4121 0.3110 0.1532 1.5817 0.0374 1.5209 0.0532</span> -<span class="r-out co"><span class="r-pr">#></span> 97: 92.2983 -6.3023 -0.0776 2.3615 -0.9801 1.2757 4.6193 0.4221 0.3018 0.1455 1.5971 0.0337 1.2137 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 98: 92.1433 -6.3114 -0.0935 2.3269 -0.9866 1.2227 4.8121 0.4327 0.2907 0.1694 1.5524 0.0303 1.1779 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 99: 92.1631 -6.3090 -0.0908 2.3197 -0.9891 1.1615 4.9271 0.4169 0.2859 0.1736 1.5303 0.0334 1.6227 0.0511</span> -<span class="r-out co"><span class="r-pr">#></span> 100: 92.1185 -6.3603 -0.0950 2.3280 -1.0209 1.1035 5.0957 0.4213 0.2924 0.1817 1.5991 0.0330 1.7197 0.0445</span> -<span class="r-out co"><span class="r-pr">#></span> 101: 92.3964 -6.0447 -0.0898 2.3347 -1.0164 1.0483 4.8409 0.4251 0.2778 0.1727 1.5708 0.0422 1.6197 0.0461</span> -<span class="r-out co"><span class="r-pr">#></span> 102: 92.6597 -6.2545 -0.0954 2.3264 -1.0206 0.9959 4.5989 0.4218 0.2736 0.1640 1.5853 0.0408 1.5912 0.0455</span> -<span class="r-out co"><span class="r-pr">#></span> 103: 92.7866 -6.3292 -0.0933 2.3148 -1.0013 0.9461 4.8935 0.4234 0.2599 0.1688 1.6299 0.0399 1.5921 0.0445</span> -<span class="r-out co"><span class="r-pr">#></span> 104: 92.8098 -6.2608 -0.1009 2.3014 -0.9947 0.8988 4.7750 0.4306 0.2548 0.1813 1.6363 0.0378 1.6713 0.0427</span> -<span class="r-out co"><span class="r-pr">#></span> 105: 92.8300 -5.9827 -0.1028 2.3155 -0.9896 0.8538 4.5362 0.4339 0.2664 0.1722 1.6079 0.0397 1.3691 0.0573</span> -<span class="r-out co"><span class="r-pr">#></span> 106: 92.8218 -6.1138 -0.1024 2.3462 -0.9750 0.8299 4.3094 0.4494 0.2530 0.1636 1.5761 0.0389 1.2857 0.0595</span> -<span class="r-out co"><span class="r-pr">#></span> 107: 92.9304 -6.0063 -0.1002 2.3269 -0.9778 0.7884 4.0939 0.4600 0.2404 0.1620 1.6499 0.0373 1.2101 0.0675</span> -<span class="r-out co"><span class="r-pr">#></span> 108: 92.9072 -6.0928 -0.0991 2.3183 -0.9732 0.7489 4.4394 0.4584 0.2518 0.1539 1.6509 0.0332 1.2346 0.0670</span> -<span class="r-out co"><span class="r-pr">#></span> 109: 92.7504 -6.1545 -0.0862 2.3423 -0.9618 0.7115 4.7501 0.4371 0.2766 0.1465 1.5755 0.0349 1.1552 0.0701</span> -<span class="r-out co"><span class="r-pr">#></span> 110: 92.9277 -6.3786 -0.0904 2.3468 -0.9402 0.6759 5.8620 0.4328 0.2821 0.1703 1.4661 0.0439 1.3292 0.0609</span> -<span class="r-out co"><span class="r-pr">#></span> 111: 92.8023 -5.8686 -0.0886 2.3653 -0.9417 0.7635 5.5689 0.4288 0.2680 0.1618 1.4278 0.0502 1.4715 0.0468</span> -<span class="r-out co"><span class="r-pr">#></span> 112: 92.9411 -5.8095 -0.0883 2.3625 -0.9322 0.8592 5.2905 0.4562 0.2586 0.1537 1.3920 0.0513 1.1766 0.0648</span> -<span class="r-out co"><span class="r-pr">#></span> 113: 92.9845 -6.0499 -0.0761 2.3626 -0.9533 0.8163 5.0259 0.4403 0.2595 0.1532 1.4306 0.0450 1.1416 0.0645</span> -<span class="r-out co"><span class="r-pr">#></span> 114: 92.7735 -6.0605 -0.0694 2.3497 -0.9646 0.7754 4.7746 0.4394 0.2682 0.1576 1.4866 0.0344 1.1127 0.0745</span> -<span class="r-out co"><span class="r-pr">#></span> 115: 92.7048 -6.1327 -0.0702 2.3427 -0.9910 0.7367 4.5359 0.4257 0.2736 0.1497 1.5045 0.0413 1.2783 0.0677</span> -<span class="r-out co"><span class="r-pr">#></span> 116: 92.7131 -6.0115 -0.0751 2.3370 -0.9899 0.6998 4.3091 0.4187 0.2638 0.1422 1.6036 0.0325 1.1109 0.0748</span> -<span class="r-out co"><span class="r-pr">#></span> 117: 92.7720 -5.9163 -0.0709 2.3503 -0.9566 0.6648 4.0937 0.4185 0.2555 0.1417 1.6016 0.0297 1.0778 0.0774</span> -<span class="r-out co"><span class="r-pr">#></span> 118: 92.9182 -5.9312 -0.0812 2.3436 -0.9731 0.6316 3.8890 0.4084 0.2667 0.1400 1.5698 0.0320 1.2364 0.0665</span> -<span class="r-out co"><span class="r-pr">#></span> 119: 92.9546 -5.9622 -0.0870 2.3330 -0.9934 0.6000 3.6945 0.4035 0.2867 0.1486 1.5364 0.0343 1.5892 0.0489</span> -<span class="r-out co"><span class="r-pr">#></span> 120: 92.9168 -6.0966 -0.0905 2.3301 -1.0045 0.5700 3.6677 0.3988 0.2871 0.1567 1.5378 0.0349 1.0886 0.0796</span> -<span class="r-out co"><span class="r-pr">#></span> 121: 92.7767 -6.1038 -0.0802 2.3396 -0.9815 0.5981 4.3032 0.3803 0.2884 0.1684 1.4788 0.0335 1.0886 0.0796</span> -<span class="r-out co"><span class="r-pr">#></span> 122: 92.8439 -6.2425 -0.0799 2.3323 -0.9987 0.6537 4.5745 0.3884 0.2834 0.1600 1.4786 0.0346 1.2146 0.0682</span> -<span class="r-out co"><span class="r-pr">#></span> 123: 92.8219 -5.7869 -0.0872 2.3478 -0.9619 0.7886 4.3458 0.3951 0.2887 0.1658 1.4827 0.0341 1.3911 0.0559</span> -<span class="r-out co"><span class="r-pr">#></span> 124: 92.7930 -5.7551 -0.0819 2.3559 -0.9809 0.8922 4.1285 0.3907 0.2972 0.1575 1.5329 0.0330 1.3824 0.0594</span> -<span class="r-out co"><span class="r-pr">#></span> 125: 92.7488 -5.9406 -0.0819 2.3550 -0.9797 0.8476 3.9221 0.3907 0.2996 0.1733 1.5096 0.0333 1.3148 0.0667</span> -<span class="r-out co"><span class="r-pr">#></span> 126: 92.7926 -5.7106 -0.0824 2.3560 -0.9653 0.8052 3.7260 0.3918 0.3018 0.1854 1.4237 0.0381 1.2607 0.0639</span> -<span class="r-out co"><span class="r-pr">#></span> 127: 92.9153 -5.6682 -0.0717 2.3654 -0.9645 0.7649 3.5397 0.3722 0.2948 0.1784 1.4679 0.0415 1.2310 0.0695</span> -<span class="r-out co"><span class="r-pr">#></span> 128: 92.8827 -5.7984 -0.0783 2.3813 -1.0047 1.1012 3.3627 0.3802 0.2997 0.1694 1.5187 0.0442 1.2884 0.0649</span> -<span class="r-out co"><span class="r-pr">#></span> 129: 92.8727 -5.7191 -0.0785 2.3426 -0.9857 1.0461 3.1946 0.3784 0.2984 0.1610 1.4757 0.0398 1.1695 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 130: 92.8689 -5.8036 -0.0935 2.3123 -0.9783 0.9938 3.0348 0.4184 0.2980 0.1723 1.5143 0.0319 1.2298 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 131: 92.8733 -5.6707 -0.0988 2.3045 -0.9936 1.3313 2.8831 0.4277 0.2831 0.1816 1.5919 0.0329 1.5260 0.0533</span> -<span class="r-out co"><span class="r-pr">#></span> 132: 92.5761 -5.7773 -0.0925 2.3211 -0.9661 1.2647 2.7389 0.4216 0.2815 0.1995 1.5306 0.0321 1.5863 0.0520</span> -<span class="r-out co"><span class="r-pr">#></span> 133: 92.4512 -5.7800 -0.0920 2.3269 -0.9625 1.2015 2.6020 0.4242 0.2674 0.1955 1.5669 0.0288 1.4087 0.0606</span> -<span class="r-out co"><span class="r-pr">#></span> 134: 92.5625 -5.7968 -0.0965 2.3271 -0.9728 1.1414 2.4719 0.4201 0.2753 0.1945 1.5935 0.0311 1.5348 0.0534</span> -<span class="r-out co"><span class="r-pr">#></span> 135: 92.3448 -5.6624 -0.0961 2.3303 -0.9600 1.0843 2.3483 0.4193 0.2728 0.1983 1.6245 0.0305 1.6281 0.0506</span> -<span class="r-out co"><span class="r-pr">#></span> 136: 92.3407 -5.7523 -0.0932 2.3208 -0.9897 1.0301 2.3267 0.4107 0.2668 0.1884 1.5933 0.0358 1.2970 0.0657</span> -<span class="r-out co"><span class="r-pr">#></span> 137: 92.3940 -6.0148 -0.1046 2.2981 -0.9866 0.9786 3.1382 0.4166 0.3012 0.1790 1.5077 0.0385 1.1944 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 138: 92.3556 -5.9912 -0.1039 2.2969 -0.9920 0.9297 3.2144 0.4208 0.3039 0.1703 1.5042 0.0378 1.2588 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 139: 92.5548 -5.9253 -0.1177 2.2723 -1.0079 0.8832 3.2648 0.4049 0.3263 0.1618 1.5558 0.0382 1.2673 0.0698</span> -<span class="r-out co"><span class="r-pr">#></span> 140: 92.6546 -6.0596 -0.1368 2.2659 -0.9922 0.8390 3.3893 0.3846 0.3100 0.1537 1.5475 0.0355 1.3190 0.0629</span> -<span class="r-out co"><span class="r-pr">#></span> 141: 92.6661 -5.9744 -0.1379 2.2793 -0.9754 0.8287 3.2725 0.3800 0.3178 0.1528 1.5076 0.0361 1.4087 0.0540</span> -<span class="r-out co"><span class="r-pr">#></span> 142: 92.5681 -5.7650 -0.1033 2.3249 -0.9613 0.7872 3.1089 0.3610 0.3564 0.1701 1.4733 0.0332 1.2603 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 143: 92.4184 -5.6070 -0.1033 2.3520 -0.9764 0.7479 2.9534 0.3591 0.3758 0.1674 1.5420 0.0390 1.3280 0.0614</span> -<span class="r-out co"><span class="r-pr">#></span> 144: 92.5354 -5.6144 -0.0978 2.3801 -0.9425 0.7105 2.8058 0.3538 0.3606 0.1722 1.4884 0.0400 1.3455 0.0620</span> -<span class="r-out co"><span class="r-pr">#></span> 145: 92.4207 -5.6541 -0.0746 2.3873 -0.9633 0.6750 2.6655 0.3361 0.3426 0.1718 1.4981 0.0416 1.2440 0.0685</span> -<span class="r-out co"><span class="r-pr">#></span> 146: 92.3058 -5.6608 -0.0731 2.3755 -0.9732 0.6412 2.5322 0.3193 0.3304 0.1719 1.6391 0.0348 1.1788 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 147: 92.4067 -5.7615 -0.0746 2.3775 -0.9903 0.6091 2.4056 0.3148 0.3311 0.1709 1.6695 0.0314 1.2931 0.0676</span> -<span class="r-out co"><span class="r-pr">#></span> 148: 92.3739 -5.8812 -0.0820 2.3644 -0.9823 0.5787 2.7260 0.3332 0.3296 0.1794 1.6168 0.0303 1.3206 0.0670</span> -<span class="r-out co"><span class="r-pr">#></span> 149: 92.4456 -5.8277 -0.0921 2.3508 -0.9924 0.5498 2.8750 0.3368 0.3305 0.1917 1.5602 0.0302 1.3622 0.0608</span> -<span class="r-out co"><span class="r-pr">#></span> 150: 92.5049 -5.7964 -0.1003 2.3353 -0.9809 0.5223 2.7312 0.3291 0.3634 0.1874 1.5035 0.0301 1.4002 0.0615</span> -<span class="r-out co"><span class="r-pr">#></span> 151: 92.3292 -6.0377 -0.1039 2.3301 -0.9866 0.4962 3.3342 0.3348 0.3626 0.1780 1.4819 0.0298 1.3217 0.0672</span> -<span class="r-out co"><span class="r-pr">#></span> 152: 92.3747 -6.0460 -0.1023 2.3154 -1.0242 0.5079 3.4530 0.3371 0.3518 0.1674 1.6034 0.0296 1.2304 0.0749</span> -<span class="r-out co"><span class="r-pr">#></span> 153: 92.3909 -5.8707 -0.1008 2.3284 -0.9897 0.5623 2.8180 0.3480 0.3792 0.1749 1.4953 0.0291 1.3442 0.0677</span> -<span class="r-out co"><span class="r-pr">#></span> 154: 92.2532 -5.9313 -0.0991 2.3232 -0.9839 0.5340 3.3946 0.3502 0.3723 0.1729 1.4837 0.0280 1.1452 0.0776</span> -<span class="r-out co"><span class="r-pr">#></span> 155: 92.1782 -6.1012 -0.0988 2.3339 -0.9600 0.3900 3.9676 0.3593 0.3704 0.1531 1.4927 0.0286 1.1848 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 156: 92.2225 -5.8387 -0.0991 2.3393 -0.9459 0.3294 3.0685 0.3598 0.3808 0.1568 1.5540 0.0318 1.3419 0.0671</span> -<span class="r-out co"><span class="r-pr">#></span> 157: 92.2411 -5.7045 -0.1038 2.3578 -0.9252 0.2797 2.5238 0.3716 0.3579 0.1653 1.4704 0.0373 1.1959 0.0686</span> -<span class="r-out co"><span class="r-pr">#></span> 158: 92.2865 -5.6692 -0.1009 2.3771 -0.9532 0.2840 2.4144 0.3592 0.3610 0.1641 1.5065 0.0389 1.1780 0.0674</span> -<span class="r-out co"><span class="r-pr">#></span> 159: 92.2771 -5.7526 -0.0782 2.3632 -0.9771 0.2996 2.7295 0.3357 0.3779 0.1606 1.5818 0.0366 1.1512 0.0781</span> -<span class="r-out co"><span class="r-pr">#></span> 160: 92.3400 -5.8039 -0.0811 2.3615 -0.9453 0.2707 2.7305 0.3373 0.3834 0.1528 1.4765 0.0370 1.1427 0.0756</span> -<span class="r-out co"><span class="r-pr">#></span> 161: 92.4180 -5.7448 -0.0961 2.3653 -0.9508 0.2965 2.6051 0.3666 0.3833 0.1647 1.4581 0.0364 0.9817 0.0827</span> -<span class="r-out co"><span class="r-pr">#></span> 162: 92.4487 -5.8952 -0.0889 2.3460 -0.9646 0.2370 3.1413 0.3460 0.3801 0.1571 1.4528 0.0346 1.0006 0.0798</span> -<span class="r-out co"><span class="r-pr">#></span> 163: 92.5251 -5.8567 -0.0987 2.3342 -0.9615 0.1453 2.9917 0.3535 0.3735 0.1452 1.4521 0.0330 1.0498 0.0766</span> -<span class="r-out co"><span class="r-pr">#></span> 164: 92.5949 -6.1580 -0.1008 2.3332 -0.9749 0.1095 4.1797 0.3586 0.3767 0.1355 1.4659 0.0310 1.0218 0.0797</span> -<span class="r-out co"><span class="r-pr">#></span> 165: 92.5794 -6.0542 -0.1001 2.3321 -0.9795 0.1332 4.2924 0.3588 0.3752 0.1386 1.4858 0.0313 0.9836 0.0812</span> -<span class="r-out co"><span class="r-pr">#></span> 166: 92.6686 -6.0065 -0.0960 2.3623 -0.9532 0.1465 4.0810 0.3439 0.3683 0.1647 1.3929 0.0372 0.9354 0.0837</span> -<span class="r-out co"><span class="r-pr">#></span> 167: 92.7086 -6.2096 -0.0895 2.3656 -0.9552 0.1938 4.6857 0.3325 0.3519 0.1681 1.4281 0.0362 1.0329 0.0784</span> -<span class="r-out co"><span class="r-pr">#></span> 168: 92.6096 -6.0709 -0.0880 2.3595 -0.9474 0.2141 4.1277 0.3379 0.3527 0.1620 1.4264 0.0347 0.9627 0.0836</span> -<span class="r-out co"><span class="r-pr">#></span> 169: 92.5365 -5.9418 -0.0919 2.3546 -0.9575 0.3620 3.7767 0.3489 0.3589 0.1609 1.4761 0.0360 1.1348 0.0745</span> -<span class="r-out co"><span class="r-pr">#></span> 170: 92.6270 -5.8404 -0.0935 2.3562 -0.9517 0.3312 3.2506 0.3552 0.3607 0.1560 1.4506 0.0383 1.0731 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 171: 92.5606 -5.9213 -0.0899 2.3513 -0.9554 0.4399 3.5587 0.3599 0.3646 0.1385 1.4779 0.0349 0.9844 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 172: 92.3630 -5.7066 -0.0765 2.3798 -0.9314 0.5208 2.5578 0.3458 0.3657 0.1547 1.4900 0.0348 1.0485 0.0765</span> -<span class="r-out co"><span class="r-pr">#></span> 173: 92.2527 -5.5811 -0.0713 2.4173 -0.9221 0.8674 2.2100 0.3448 0.3370 0.1513 1.5403 0.0445 1.4403 0.0518</span> -<span class="r-out co"><span class="r-pr">#></span> 174: 92.3852 -5.5348 -0.0712 2.4066 -0.9033 0.7543 2.1568 0.3457 0.3324 0.1482 1.5322 0.0407 1.2744 0.0623</span> -<span class="r-out co"><span class="r-pr">#></span> 175: 92.4798 -5.5494 -0.0712 2.4004 -0.9100 0.5675 2.0147 0.3457 0.3333 0.1629 1.5229 0.0383 1.2917 0.0655</span> -<span class="r-out co"><span class="r-pr">#></span> 176: 92.5881 -5.5613 -0.0675 2.4180 -0.9188 0.4011 2.0736 0.3413 0.3487 0.1781 1.5149 0.0389 1.1499 0.0669</span> -<span class="r-out co"><span class="r-pr">#></span> 177: 92.6015 -5.4951 -0.0494 2.4324 -0.9525 0.4992 1.9009 0.3629 0.3353 0.1919 1.4881 0.0393 1.2289 0.0650</span> -<span class="r-out co"><span class="r-pr">#></span> 178: 92.6317 -5.4943 -0.0505 2.4373 -0.9298 0.5087 1.6116 0.3631 0.3324 0.1906 1.4475 0.0454 1.0764 0.0701</span> -<span class="r-out co"><span class="r-pr">#></span> 179: 92.7043 -5.5326 -0.0419 2.4386 -0.9376 0.4350 1.8241 0.3577 0.3757 0.1991 1.4445 0.0424 0.9626 0.0833</span> -<span class="r-out co"><span class="r-pr">#></span> 180: 92.7457 -5.5591 -0.0371 2.4684 -0.9450 0.3973 1.7797 0.3507 0.3707 0.1944 1.4392 0.0415 1.0784 0.0764</span> -<span class="r-out co"><span class="r-pr">#></span> 181: 92.6287 -5.5741 -0.0368 2.4489 -0.9459 0.4744 1.8016 0.3502 0.3544 0.1970 1.4317 0.0392 0.9225 0.0848</span> -<span class="r-out co"><span class="r-pr">#></span> 182: 92.6121 -5.5593 -0.0316 2.4610 -0.9345 0.6054 1.9206 0.3492 0.3538 0.1855 1.4410 0.0367 0.8977 0.0878</span> -<span class="r-out co"><span class="r-pr">#></span> 183: 92.4258 -5.4737 -0.0393 2.4592 -0.9319 0.8062 1.7845 0.3528 0.3544 0.1649 1.4545 0.0409 1.0723 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 184: 92.3939 -5.5961 -0.0479 2.4268 -0.9435 1.0246 2.2534 0.3497 0.3289 0.1363 1.5022 0.0370 1.1058 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 185: 92.4673 -5.5415 -0.0525 2.4157 -0.9058 0.8296 2.2848 0.3406 0.3314 0.1706 1.4935 0.0367 1.1362 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 186: 92.4122 -5.6594 -0.0574 2.4466 -0.9430 0.9133 2.3350 0.3327 0.3596 0.1506 1.4450 0.0404 1.2273 0.0629</span> -<span class="r-out co"><span class="r-pr">#></span> 187: 92.5416 -5.5472 -0.0521 2.4393 -0.9261 0.9731 1.9228 0.3208 0.3673 0.1421 1.4890 0.0409 1.2553 0.0626</span> -<span class="r-out co"><span class="r-pr">#></span> 188: 92.5502 -5.6425 -0.0591 2.4345 -0.9246 0.9315 2.2041 0.3184 0.3639 0.1319 1.4896 0.0392 1.0986 0.0684</span> -<span class="r-out co"><span class="r-pr">#></span> 189: 92.4180 -5.6737 -0.0504 2.4448 -0.9191 0.9006 2.4647 0.3102 0.3743 0.1648 1.4649 0.0397 1.1320 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 190: 92.5821 -5.5823 -0.0363 2.4588 -0.9205 0.9862 2.2692 0.2820 0.4087 0.1459 1.3938 0.0412 0.9562 0.0815</span> -<span class="r-out co"><span class="r-pr">#></span> 191: 92.3708 -5.5825 -0.0418 2.4621 -0.9231 0.9867 2.4743 0.2890 0.4196 0.1445 1.4619 0.0403 0.9630 0.0811</span> -<span class="r-out co"><span class="r-pr">#></span> 192: 92.2628 -5.5337 -0.0366 2.4392 -0.9194 0.6944 2.2771 0.2909 0.4169 0.1279 1.4745 0.0363 0.8601 0.0892</span> -<span class="r-out co"><span class="r-pr">#></span> 193: 92.4854 -5.6303 -0.0352 2.4484 -0.9316 0.4403 2.3253 0.2928 0.4109 0.1282 1.4768 0.0399 0.8886 0.0871</span> -<span class="r-out co"><span class="r-pr">#></span> 194: 92.4900 -5.5824 -0.0372 2.4648 -0.9451 0.4891 2.6428 0.2899 0.4160 0.1331 1.5124 0.0412 0.9340 0.0853</span> -<span class="r-out co"><span class="r-pr">#></span> 195: 92.4685 -5.7658 -0.0357 2.4659 -0.9217 0.4549 3.3767 0.2921 0.4171 0.1552 1.5062 0.0396 1.0336 0.0817</span> -<span class="r-out co"><span class="r-pr">#></span> 196: 92.4125 -5.7544 -0.0255 2.4834 -0.9230 0.4146 3.1963 0.3000 0.4369 0.1501 1.4560 0.0430 0.9942 0.0813</span> -<span class="r-out co"><span class="r-pr">#></span> 197: 92.3284 -5.9347 -0.0305 2.4860 -0.9448 0.4115 3.5642 0.3129 0.4314 0.1740 1.3441 0.0473 1.0954 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 198: 92.3428 -5.9255 -0.0266 2.4822 -0.9463 0.3258 3.4818 0.3185 0.4163 0.1716 1.3868 0.0447 0.9452 0.0788</span> -<span class="r-out co"><span class="r-pr">#></span> 199: 92.1692 -6.0683 -0.0227 2.4860 -0.9495 0.2685 4.4044 0.3149 0.4064 0.1824 1.3558 0.0478 1.0294 0.0749</span> -<span class="r-out co"><span class="r-pr">#></span> 200: 92.0965 -6.1541 -0.0261 2.4793 -0.9288 0.2210 4.4026 0.3265 0.4200 0.1772 1.3348 0.0441 1.0018 0.0761</span> -<span class="r-out co"><span class="r-pr">#></span> 201: 92.1362 -6.1170 -0.0244 2.4776 -0.9237 0.1801 4.4160 0.3276 0.4303 0.1732 1.3479 0.0418 0.9419 0.0809</span> -<span class="r-out co"><span class="r-pr">#></span> 202: 92.1114 -6.0898 -0.0233 2.4862 -0.9253 0.1506 4.4494 0.3286 0.4305 0.1656 1.3473 0.0440 0.9394 0.0802</span> -<span class="r-out co"><span class="r-pr">#></span> 203: 92.0893 -6.1307 -0.0233 2.4894 -0.9258 0.1510 4.7958 0.3310 0.4233 0.1673 1.3396 0.0457 0.9617 0.0788</span> -<span class="r-out co"><span class="r-pr">#></span> 204: 92.0870 -6.0914 -0.0230 2.4867 -0.9234 0.1589 4.6265 0.3316 0.4237 0.1643 1.3478 0.0456 0.9509 0.0793</span> -<span class="r-out co"><span class="r-pr">#></span> 205: 92.0800 -6.0960 -0.0228 2.4867 -0.9256 0.1613 4.6319 0.3321 0.4226 0.1623 1.3399 0.0463 0.9547 0.0789</span> -<span class="r-out co"><span class="r-pr">#></span> 206: 92.1037 -6.0869 -0.0238 2.4833 -0.9264 0.1648 4.5547 0.3341 0.4186 0.1606 1.3351 0.0466 0.9453 0.0797</span> -<span class="r-out co"><span class="r-pr">#></span> 207: 92.1212 -6.0561 -0.0247 2.4821 -0.9299 0.1677 4.3736 0.3363 0.4150 0.1602 1.3394 0.0467 0.9552 0.0790</span> -<span class="r-out co"><span class="r-pr">#></span> 208: 92.1203 -6.0351 -0.0260 2.4804 -0.9309 0.1616 4.2520 0.3369 0.4120 0.1613 1.3366 0.0466 0.9667 0.0785</span> -<span class="r-out co"><span class="r-pr">#></span> 209: 92.1169 -6.0133 -0.0277 2.4792 -0.9300 0.1596 4.1237 0.3352 0.4111 0.1616 1.3344 0.0464 0.9741 0.0778</span> -<span class="r-out co"><span class="r-pr">#></span> 210: 92.1195 -5.9866 -0.0289 2.4752 -0.9287 0.1586 3.9853 0.3352 0.4091 0.1602 1.3410 0.0461 0.9708 0.0778</span> -<span class="r-out co"><span class="r-pr">#></span> 211: 92.1243 -5.9458 -0.0316 2.4687 -0.9287 0.1606 3.8383 0.3366 0.4094 0.1607 1.3525 0.0455 0.9759 0.0778</span> -<span class="r-out co"><span class="r-pr">#></span> 212: 92.1384 -5.9338 -0.0345 2.4640 -0.9280 0.1635 3.7875 0.3375 0.4105 0.1594 1.3589 0.0454 0.9800 0.0776</span> -<span class="r-out co"><span class="r-pr">#></span> 213: 92.1481 -5.9191 -0.0379 2.4587 -0.9269 0.1629 3.7150 0.3375 0.4100 0.1586 1.3673 0.0449 0.9839 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 214: 92.1523 -5.9189 -0.0408 2.4542 -0.9270 0.1593 3.7061 0.3375 0.4092 0.1579 1.3731 0.0446 0.9847 0.0773</span> -<span class="r-out co"><span class="r-pr">#></span> 215: 92.1548 -5.9183 -0.0429 2.4499 -0.9269 0.1604 3.7075 0.3369 0.4095 0.1574 1.3765 0.0442 0.9821 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 216: 92.1547 -5.9171 -0.0450 2.4455 -0.9270 0.1600 3.6967 0.3368 0.4100 0.1571 1.3811 0.0438 0.9830 0.0776</span> -<span class="r-out co"><span class="r-pr">#></span> 217: 92.1556 -5.9141 -0.0468 2.4422 -0.9281 0.1580 3.6732 0.3361 0.4102 0.1578 1.3864 0.0435 0.9995 0.0770</span> -<span class="r-out co"><span class="r-pr">#></span> 218: 92.1587 -5.9173 -0.0477 2.4395 -0.9287 0.1545 3.6822 0.3351 0.4112 0.1580 1.3882 0.0432 1.0001 0.0772</span> -<span class="r-out co"><span class="r-pr">#></span> 219: 92.1590 -5.9188 -0.0483 2.4374 -0.9303 0.1540 3.6595 0.3341 0.4132 0.1578 1.3889 0.0430 0.9983 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 220: 92.1614 -5.9303 -0.0493 2.4353 -0.9321 0.1559 3.6914 0.3336 0.4141 0.1581 1.3914 0.0427 1.0003 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 221: 92.1657 -5.9455 -0.0504 2.4328 -0.9344 0.1585 3.7569 0.3329 0.4140 0.1591 1.3938 0.0424 1.0064 0.0773</span> -<span class="r-out co"><span class="r-pr">#></span> 222: 92.1697 -5.9320 -0.0515 2.4306 -0.9358 0.1617 3.6783 0.3321 0.4145 0.1600 1.3992 0.0421 1.0107 0.0772</span> -<span class="r-out co"><span class="r-pr">#></span> 223: 92.1754 -5.9205 -0.0525 2.4280 -0.9375 0.1630 3.6233 0.3313 0.4158 0.1604 1.4072 0.0416 1.0216 0.0770</span> -<span class="r-out co"><span class="r-pr">#></span> 224: 92.1809 -5.9149 -0.0534 2.4264 -0.9386 0.1623 3.5812 0.3306 0.4167 0.1607 1.4130 0.0413 1.0349 0.0764</span> -<span class="r-out co"><span class="r-pr">#></span> 225: 92.1872 -5.9099 -0.0543 2.4243 -0.9390 0.1619 3.5446 0.3299 0.4174 0.1607 1.4152 0.0411 1.0348 0.0766</span> -<span class="r-out co"><span class="r-pr">#></span> 226: 92.1935 -5.9046 -0.0554 2.4224 -0.9396 0.1631 3.5046 0.3299 0.4183 0.1608 1.4157 0.0409 1.0375 0.0766</span> -<span class="r-out co"><span class="r-pr">#></span> 227: 92.2026 -5.8964 -0.0567 2.4198 -0.9400 0.1637 3.4591 0.3303 0.4183 0.1614 1.4144 0.0408 1.0444 0.0763</span> -<span class="r-out co"><span class="r-pr">#></span> 228: 92.2069 -5.8852 -0.0578 2.4175 -0.9407 0.1633 3.4091 0.3308 0.4185 0.1621 1.4144 0.0407 1.0485 0.0763</span> -<span class="r-out co"><span class="r-pr">#></span> 229: 92.2122 -5.8844 -0.0591 2.4145 -0.9418 0.1631 3.3899 0.3314 0.4194 0.1622 1.4173 0.0404 1.0514 0.0763</span> -<span class="r-out co"><span class="r-pr">#></span> 230: 92.2183 -5.8907 -0.0604 2.4116 -0.9416 0.1640 3.4053 0.3319 0.4202 0.1616 1.4200 0.0401 1.0527 0.0764</span> -<span class="r-out co"><span class="r-pr">#></span> 231: 92.2246 -5.8895 -0.0619 2.4087 -0.9422 0.1651 3.3985 0.3323 0.4208 0.1609 1.4234 0.0400 1.0560 0.0762</span> -<span class="r-out co"><span class="r-pr">#></span> 232: 92.2282 -5.8840 -0.0632 2.4058 -0.9423 0.1641 3.3771 0.3327 0.4215 0.1609 1.4266 0.0398 1.0585 0.0762</span> -<span class="r-out co"><span class="r-pr">#></span> 233: 92.2294 -5.8775 -0.0645 2.4032 -0.9424 0.1620 3.3481 0.3335 0.4216 0.1607 1.4311 0.0395 1.0600 0.0763</span> -<span class="r-out co"><span class="r-pr">#></span> 234: 92.2311 -5.8709 -0.0658 2.4006 -0.9421 0.1626 3.3242 0.3343 0.4220 0.1602 1.4340 0.0393 1.0604 0.0764</span> -<span class="r-out co"><span class="r-pr">#></span> 235: 92.2312 -5.8656 -0.0668 2.3985 -0.9420 0.1608 3.3023 0.3350 0.4225 0.1596 1.4381 0.0391 1.0600 0.0765</span> -<span class="r-out co"><span class="r-pr">#></span> 236: 92.2289 -5.8633 -0.0675 2.3974 -0.9423 0.1599 3.2811 0.3352 0.4227 0.1589 1.4392 0.0390 1.0594 0.0765</span> -<span class="r-out co"><span class="r-pr">#></span> 237: 92.2251 -5.8641 -0.0683 2.3960 -0.9435 0.1586 3.2734 0.3351 0.4226 0.1588 1.4403 0.0389 1.0623 0.0765</span> -<span class="r-out co"><span class="r-pr">#></span> 238: 92.2242 -5.8633 -0.0690 2.3949 -0.9443 0.1579 3.2547 0.3349 0.4230 0.1590 1.4409 0.0389 1.0659 0.0765</span> -<span class="r-out co"><span class="r-pr">#></span> 239: 92.2250 -5.8612 -0.0693 2.3951 -0.9449 0.1558 3.2309 0.3346 0.4234 0.1599 1.4396 0.0389 1.0740 0.0762</span> -<span class="r-out co"><span class="r-pr">#></span> 240: 92.2264 -5.8597 -0.0696 2.3949 -0.9446 0.1550 3.2124 0.3342 0.4234 0.1603 1.4401 0.0388 1.0791 0.0760</span> -<span class="r-out co"><span class="r-pr">#></span> 241: 92.2281 -5.8562 -0.0699 2.3948 -0.9449 0.1544 3.1933 0.3339 0.4236 0.1604 1.4411 0.0388 1.0825 0.0760</span> -<span class="r-out co"><span class="r-pr">#></span> 242: 92.2289 -5.8512 -0.0703 2.3942 -0.9450 0.1534 3.1709 0.3338 0.4235 0.1606 1.4421 0.0388 1.0870 0.0760</span> -<span class="r-out co"><span class="r-pr">#></span> 243: 92.2296 -5.8489 -0.0708 2.3934 -0.9446 0.1531 3.1689 0.3342 0.4230 0.1605 1.4423 0.0387 1.0876 0.0760</span> -<span class="r-out co"><span class="r-pr">#></span> 244: 92.2311 -5.8446 -0.0715 2.3929 -0.9443 0.1528 3.1630 0.3349 0.4228 0.1604 1.4429 0.0387 1.0916 0.0759</span> -<span class="r-out co"><span class="r-pr">#></span> 245: 92.2338 -5.8421 -0.0718 2.3924 -0.9443 0.1528 3.1616 0.3352 0.4224 0.1610 1.4438 0.0387 1.0980 0.0755</span> -<span class="r-out co"><span class="r-pr">#></span> 246: 92.2361 -5.8389 -0.0721 2.3918 -0.9439 0.1525 3.1525 0.3354 0.4216 0.1620 1.4438 0.0388 1.1018 0.0753</span> -<span class="r-out co"><span class="r-pr">#></span> 247: 92.2374 -5.8388 -0.0724 2.3917 -0.9434 0.1510 3.1605 0.3356 0.4212 0.1629 1.4438 0.0389 1.1050 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 248: 92.2360 -5.8367 -0.0728 2.3918 -0.9432 0.1505 3.1559 0.3360 0.4207 0.1638 1.4437 0.0389 1.1090 0.0748</span> -<span class="r-out co"><span class="r-pr">#></span> 249: 92.2361 -5.8351 -0.0732 2.3914 -0.9435 0.1499 3.1521 0.3363 0.4204 0.1646 1.4433 0.0389 1.1117 0.0748</span> -<span class="r-out co"><span class="r-pr">#></span> 250: 92.2353 -5.8349 -0.0733 2.3906 -0.9436 0.1502 3.1607 0.3365 0.4202 0.1646 1.4457 0.0388 1.1107 0.0749</span> -<span class="r-out co"><span class="r-pr">#></span> 251: 92.2343 -5.8318 -0.0736 2.3903 -0.9430 0.1494 3.1513 0.3367 0.4201 0.1648 1.4453 0.0387 1.1093 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 252: 92.2356 -5.8244 -0.0739 2.3895 -0.9424 0.1477 3.1240 0.3369 0.4200 0.1651 1.4460 0.0386 1.1083 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 253: 92.2367 -5.8188 -0.0742 2.3890 -0.9423 0.1465 3.1025 0.3369 0.4200 0.1649 1.4477 0.0385 1.1092 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 254: 92.2392 -5.8154 -0.0747 2.3880 -0.9421 0.1458 3.0888 0.3372 0.4195 0.1644 1.4494 0.0384 1.1080 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 255: 92.2404 -5.8131 -0.0751 2.3870 -0.9417 0.1451 3.0778 0.3375 0.4191 0.1639 1.4501 0.0383 1.1070 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 256: 92.2408 -5.8109 -0.0753 2.3867 -0.9413 0.1445 3.0740 0.3376 0.4192 0.1633 1.4510 0.0382 1.1064 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 257: 92.2413 -5.8066 -0.0754 2.3866 -0.9409 0.1446 3.0636 0.3376 0.4191 0.1628 1.4522 0.0382 1.1080 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 258: 92.2412 -5.8035 -0.0754 2.3869 -0.9404 0.1436 3.0502 0.3372 0.4191 0.1623 1.4534 0.0381 1.1057 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 259: 92.2399 -5.7996 -0.0753 2.3871 -0.9399 0.1427 3.0357 0.3370 0.4195 0.1621 1.4540 0.0380 1.1037 0.0752</span> -<span class="r-out co"><span class="r-pr">#></span> 260: 92.2389 -5.7955 -0.0755 2.3872 -0.9391 0.1420 3.0251 0.3366 0.4199 0.1619 1.4555 0.0380 1.1041 0.0752</span> -<span class="r-out co"><span class="r-pr">#></span> 261: 92.2378 -5.7941 -0.0755 2.3875 -0.9385 0.1412 3.0240 0.3362 0.4201 0.1613 1.4575 0.0380 1.1048 0.0751</span> -<span class="r-out co"><span class="r-pr">#></span> 262: 92.2361 -5.7920 -0.0756 2.3879 -0.9379 0.1407 3.0182 0.3358 0.4205 0.1607 1.4581 0.0381 1.1047 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 263: 92.2338 -5.7891 -0.0754 2.3883 -0.9375 0.1407 3.0072 0.3356 0.4211 0.1603 1.4585 0.0381 1.1041 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 264: 92.2313 -5.7882 -0.0752 2.3886 -0.9371 0.1407 3.0009 0.3355 0.4217 0.1601 1.4574 0.0381 1.1036 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 265: 92.2312 -5.7843 -0.0752 2.3883 -0.9372 0.1402 2.9872 0.3358 0.4220 0.1599 1.4577 0.0381 1.1026 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 266: 92.2312 -5.7800 -0.0753 2.3880 -0.9370 0.1396 2.9708 0.3363 0.4223 0.1597 1.4584 0.0381 1.1019 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 267: 92.2306 -5.7785 -0.0755 2.3878 -0.9372 0.1397 2.9619 0.3368 0.4227 0.1595 1.4578 0.0381 1.1021 0.0750</span> -<span class="r-out co"><span class="r-pr">#></span> 268: 92.2287 -5.7803 -0.0758 2.3870 -0.9372 0.1394 2.9777 0.3375 0.4226 0.1594 1.4578 0.0380 1.1032 0.0749</span> -<span class="r-out co"><span class="r-pr">#></span> 269: 92.2265 -5.7804 -0.0761 2.3865 -0.9371 0.1399 2.9816 0.3382 0.4226 0.1592 1.4589 0.0380 1.1058 0.0747</span> -<span class="r-out co"><span class="r-pr">#></span> 270: 92.2236 -5.7811 -0.0765 2.3860 -0.9369 0.1411 2.9893 0.3386 0.4227 0.1591 1.4597 0.0380 1.1081 0.0745</span> -<span class="r-out co"><span class="r-pr">#></span> 271: 92.2211 -5.7793 -0.0769 2.3852 -0.9365 0.1421 2.9888 0.3390 0.4228 0.1591 1.4606 0.0379 1.1083 0.0745</span> -<span class="r-out co"><span class="r-pr">#></span> 272: 92.2187 -5.7773 -0.0773 2.3845 -0.9361 0.1423 2.9810 0.3396 0.4232 0.1589 1.4617 0.0378 1.1076 0.0746</span> -<span class="r-out co"><span class="r-pr">#></span> 273: 92.2164 -5.7769 -0.0776 2.3838 -0.9356 0.1427 2.9809 0.3402 0.4240 0.1589 1.4615 0.0378 1.1073 0.0746</span> -<span class="r-out co"><span class="r-pr">#></span> 274: 92.2145 -5.7763 -0.0778 2.3836 -0.9355 0.1434 2.9795 0.3407 0.4248 0.1589 1.4615 0.0378 1.1069 0.0746</span> -<span class="r-out co"><span class="r-pr">#></span> 275: 92.2133 -5.7762 -0.0779 2.3836 -0.9352 0.1436 2.9837 0.3410 0.4253 0.1589 1.4621 0.0378 1.1064 0.0746</span> -<span class="r-out co"><span class="r-pr">#></span> 276: 92.2123 -5.7764 -0.0781 2.3835 -0.9348 0.1431 2.9889 0.3414 0.4255 0.1589 1.4632 0.0378 1.1073 0.0746</span> -<span class="r-out co"><span class="r-pr">#></span> 277: 92.2113 -5.7771 -0.0781 2.3839 -0.9347 0.1423 2.9925 0.3423 0.4264 0.1589 1.4630 0.0378 1.1104 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 278: 92.2099 -5.7774 -0.0780 2.3841 -0.9349 0.1418 2.9927 0.3429 0.4270 0.1590 1.4634 0.0378 1.1127 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 279: 92.2087 -5.7798 -0.0779 2.3844 -0.9352 0.1413 2.9997 0.3437 0.4276 0.1590 1.4630 0.0378 1.1133 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 280: 92.2077 -5.7802 -0.0778 2.3841 -0.9358 0.1407 2.9971 0.3445 0.4284 0.1586 1.4634 0.0378 1.1136 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 281: 92.2061 -5.7814 -0.0777 2.3837 -0.9362 0.1401 3.0004 0.3452 0.4291 0.1582 1.4629 0.0378 1.1133 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 282: 92.2058 -5.7802 -0.0777 2.3834 -0.9363 0.1386 2.9994 0.3459 0.4297 0.1579 1.4634 0.0378 1.1126 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 283: 92.2057 -5.7780 -0.0778 2.3828 -0.9361 0.1376 2.9917 0.3469 0.4298 0.1576 1.4645 0.0378 1.1147 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 284: 92.2051 -5.7788 -0.0780 2.3824 -0.9360 0.1367 2.9968 0.3479 0.4300 0.1573 1.4647 0.0378 1.1149 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 285: 92.2041 -5.7793 -0.0782 2.3821 -0.9362 0.1359 2.9941 0.3487 0.4302 0.1573 1.4653 0.0378 1.1164 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 286: 92.2040 -5.7803 -0.0783 2.3819 -0.9364 0.1352 2.9957 0.3495 0.4304 0.1573 1.4655 0.0378 1.1180 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 287: 92.2044 -5.7809 -0.0784 2.3817 -0.9365 0.1348 2.9961 0.3502 0.4304 0.1572 1.4657 0.0379 1.1178 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 288: 92.2043 -5.7835 -0.0785 2.3814 -0.9366 0.1350 3.0073 0.3509 0.4304 0.1572 1.4658 0.0379 1.1184 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 289: 92.2041 -5.7845 -0.0787 2.3809 -0.9364 0.1347 3.0126 0.3516 0.4304 0.1571 1.4653 0.0379 1.1190 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 290: 92.2032 -5.7852 -0.0788 2.3807 -0.9363 0.1349 3.0161 0.3521 0.4304 0.1568 1.4656 0.0379 1.1191 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 291: 92.2019 -5.7848 -0.0790 2.3802 -0.9363 0.1356 3.0155 0.3528 0.4300 0.1565 1.4664 0.0380 1.1210 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 292: 92.2012 -5.7846 -0.0792 2.3799 -0.9363 0.1361 3.0167 0.3535 0.4296 0.1563 1.4670 0.0380 1.1223 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 293: 92.2007 -5.7845 -0.0793 2.3795 -0.9363 0.1365 3.0175 0.3542 0.4291 0.1561 1.4681 0.0380 1.1236 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 294: 92.2009 -5.7850 -0.0795 2.3791 -0.9360 0.1365 3.0189 0.3550 0.4287 0.1560 1.4682 0.0380 1.1243 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 295: 92.2009 -5.7865 -0.0797 2.3786 -0.9360 0.1360 3.0279 0.3556 0.4286 0.1558 1.4689 0.0380 1.1243 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 296: 92.2007 -5.7878 -0.0798 2.3781 -0.9362 0.1358 3.0345 0.3562 0.4283 0.1555 1.4694 0.0379 1.1247 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 297: 92.1992 -5.7891 -0.0801 2.3774 -0.9364 0.1358 3.0403 0.3568 0.4278 0.1554 1.4699 0.0379 1.1267 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 298: 92.1978 -5.7892 -0.0803 2.3768 -0.9366 0.1357 3.0383 0.3573 0.4274 0.1553 1.4706 0.0378 1.1276 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 299: 92.1968 -5.7906 -0.0805 2.3763 -0.9369 0.1353 3.0408 0.3579 0.4269 0.1553 1.4712 0.0378 1.1282 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 300: 92.1954 -5.7929 -0.0807 2.3760 -0.9369 0.1352 3.0477 0.3583 0.4265 0.1551 1.4716 0.0379 1.1286 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 301: 92.1941 -5.7934 -0.0809 2.3757 -0.9369 0.1352 3.0483 0.3588 0.4261 0.1548 1.4727 0.0378 1.1288 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 302: 92.1929 -5.7949 -0.0811 2.3754 -0.9370 0.1354 3.0560 0.3592 0.4256 0.1548 1.4728 0.0379 1.1296 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 303: 92.1919 -5.7972 -0.0813 2.3751 -0.9368 0.1352 3.0671 0.3597 0.4250 0.1550 1.4730 0.0379 1.1302 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 304: 92.1906 -5.8018 -0.0814 2.3750 -0.9368 0.1349 3.0935 0.3602 0.4245 0.1552 1.4731 0.0379 1.1314 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 305: 92.1897 -5.8063 -0.0817 2.3744 -0.9370 0.1350 3.1211 0.3606 0.4238 0.1554 1.4727 0.0379 1.1323 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 306: 92.1896 -5.8116 -0.0820 2.3740 -0.9373 0.1347 3.1571 0.3610 0.4233 0.1555 1.4727 0.0379 1.1351 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 307: 92.1895 -5.8156 -0.0822 2.3735 -0.9373 0.1341 3.1826 0.3613 0.4226 0.1552 1.4741 0.0379 1.1374 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 308: 92.1899 -5.8202 -0.0824 2.3732 -0.9376 0.1338 3.2124 0.3617 0.4220 0.1554 1.4745 0.0379 1.1408 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 309: 92.1903 -5.8232 -0.0827 2.3728 -0.9377 0.1337 3.2330 0.3620 0.4213 0.1554 1.4749 0.0379 1.1419 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 310: 92.1902 -5.8249 -0.0828 2.3727 -0.9378 0.1335 3.2463 0.3621 0.4207 0.1554 1.4752 0.0379 1.1435 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 311: 92.1910 -5.8267 -0.0828 2.3726 -0.9378 0.1335 3.2581 0.3623 0.4200 0.1554 1.4754 0.0379 1.1441 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 312: 92.1918 -5.8271 -0.0829 2.3726 -0.9378 0.1333 3.2567 0.3624 0.4195 0.1552 1.4751 0.0380 1.1432 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 313: 92.1926 -5.8260 -0.0829 2.3725 -0.9380 0.1334 3.2497 0.3626 0.4190 0.1552 1.4751 0.0380 1.1434 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 314: 92.1934 -5.8256 -0.0829 2.3724 -0.9381 0.1330 3.2426 0.3628 0.4185 0.1553 1.4746 0.0380 1.1441 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 315: 92.1938 -5.8237 -0.0829 2.3724 -0.9384 0.1326 3.2327 0.3630 0.4179 0.1555 1.4746 0.0380 1.1468 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 316: 92.1950 -5.8235 -0.0829 2.3722 -0.9385 0.1324 3.2283 0.3631 0.4172 0.1557 1.4745 0.0380 1.1476 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 317: 92.1963 -5.8239 -0.0829 2.3722 -0.9385 0.1322 3.2260 0.3633 0.4167 0.1560 1.4741 0.0380 1.1481 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 318: 92.1975 -5.8242 -0.0829 2.3722 -0.9387 0.1321 3.2240 0.3634 0.4163 0.1559 1.4740 0.0380 1.1477 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 319: 92.1990 -5.8250 -0.0829 2.3721 -0.9387 0.1320 3.2215 0.3634 0.4159 0.1560 1.4736 0.0381 1.1496 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 320: 92.2003 -5.8256 -0.0829 2.3722 -0.9386 0.1322 3.2199 0.3635 0.4155 0.1561 1.4730 0.0381 1.1508 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 321: 92.2018 -5.8249 -0.0829 2.3723 -0.9386 0.1326 3.2150 0.3635 0.4151 0.1562 1.4727 0.0381 1.1514 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 322: 92.2031 -5.8239 -0.0829 2.3724 -0.9386 0.1333 3.2081 0.3635 0.4147 0.1561 1.4729 0.0381 1.1527 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 323: 92.2045 -5.8244 -0.0829 2.3725 -0.9384 0.1336 3.2065 0.3635 0.4143 0.1562 1.4729 0.0381 1.1541 0.0716</span> -<span class="r-out co"><span class="r-pr">#></span> 324: 92.2060 -5.8228 -0.0828 2.3726 -0.9383 0.1339 3.1996 0.3635 0.4139 0.1562 1.4729 0.0382 1.1562 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 325: 92.2071 -5.8212 -0.0828 2.3727 -0.9383 0.1339 3.1921 0.3636 0.4135 0.1563 1.4733 0.0382 1.1580 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 326: 92.2083 -5.8201 -0.0826 2.3728 -0.9382 0.1340 3.1888 0.3639 0.4134 0.1562 1.4734 0.0382 1.1587 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 327: 92.2095 -5.8185 -0.0825 2.3729 -0.9379 0.1340 3.1831 0.3641 0.4134 0.1562 1.4737 0.0382 1.1592 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 328: 92.2105 -5.8188 -0.0823 2.3731 -0.9379 0.1338 3.1836 0.3643 0.4132 0.1561 1.4736 0.0383 1.1589 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 329: 92.2115 -5.8182 -0.0821 2.3732 -0.9381 0.1339 3.1807 0.3646 0.4129 0.1561 1.4737 0.0383 1.1585 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 330: 92.2127 -5.8181 -0.0819 2.3734 -0.9381 0.1338 3.1827 0.3648 0.4127 0.1563 1.4735 0.0383 1.1578 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 331: 92.2134 -5.8180 -0.0815 2.3739 -0.9381 0.1340 3.1837 0.3647 0.4128 0.1566 1.4735 0.0383 1.1575 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 332: 92.2136 -5.8184 -0.0811 2.3746 -0.9379 0.1340 3.1847 0.3647 0.4130 0.1570 1.4728 0.0384 1.1577 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 333: 92.2133 -5.8180 -0.0807 2.3753 -0.9376 0.1340 3.1853 0.3646 0.4132 0.1572 1.4725 0.0384 1.1573 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 334: 92.2136 -5.8173 -0.0803 2.3760 -0.9374 0.1342 3.1838 0.3645 0.4133 0.1576 1.4720 0.0385 1.1570 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 335: 92.2139 -5.8187 -0.0800 2.3769 -0.9372 0.1344 3.1947 0.3643 0.4135 0.1576 1.4714 0.0386 1.1567 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 336: 92.2134 -5.8198 -0.0796 2.3777 -0.9370 0.1348 3.2008 0.3641 0.4135 0.1577 1.4706 0.0387 1.1557 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 337: 92.2130 -5.8201 -0.0792 2.3784 -0.9370 0.1357 3.2050 0.3640 0.4137 0.1579 1.4703 0.0388 1.1558 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 338: 92.2130 -5.8190 -0.0787 2.3791 -0.9368 0.1362 3.2036 0.3638 0.4139 0.1580 1.4708 0.0388 1.1558 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 339: 92.2132 -5.8177 -0.0783 2.3798 -0.9368 0.1369 3.2006 0.3637 0.4142 0.1581 1.4712 0.0388 1.1551 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 340: 92.2137 -5.8167 -0.0778 2.3806 -0.9366 0.1376 3.1984 0.3636 0.4143 0.1581 1.4712 0.0388 1.1540 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 341: 92.2141 -5.8145 -0.0773 2.3814 -0.9364 0.1378 3.1916 0.3635 0.4142 0.1581 1.4712 0.0389 1.1529 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 342: 92.2142 -5.8123 -0.0769 2.3821 -0.9364 0.1383 3.1840 0.3634 0.4142 0.1581 1.4718 0.0389 1.1513 0.0716</span> -<span class="r-out co"><span class="r-pr">#></span> 343: 92.2139 -5.8109 -0.0764 2.3830 -0.9364 0.1389 3.1806 0.3632 0.4142 0.1581 1.4721 0.0389 1.1501 0.0716</span> -<span class="r-out co"><span class="r-pr">#></span> 344: 92.2137 -5.8117 -0.0759 2.3839 -0.9366 0.1390 3.1830 0.3631 0.4144 0.1582 1.4711 0.0390 1.1492 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 345: 92.2133 -5.8118 -0.0754 2.3849 -0.9368 0.1391 3.1827 0.3630 0.4146 0.1582 1.4703 0.0391 1.1488 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 346: 92.2127 -5.8113 -0.0748 2.3858 -0.9369 0.1389 3.1793 0.3629 0.4147 0.1581 1.4700 0.0391 1.1475 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 347: 92.2121 -5.8107 -0.0743 2.3867 -0.9371 0.1386 3.1748 0.3628 0.4149 0.1579 1.4701 0.0392 1.1463 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 348: 92.2106 -5.8109 -0.0738 2.3876 -0.9374 0.1385 3.1726 0.3626 0.4151 0.1577 1.4704 0.0392 1.1453 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 349: 92.2096 -5.8111 -0.0732 2.3883 -0.9377 0.1382 3.1703 0.3626 0.4151 0.1575 1.4705 0.0392 1.1448 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 350: 92.2088 -5.8108 -0.0727 2.3890 -0.9378 0.1380 3.1674 0.3625 0.4152 0.1574 1.4704 0.0392 1.1439 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 351: 92.2077 -5.8103 -0.0722 2.3899 -0.9379 0.1379 3.1634 0.3623 0.4154 0.1572 1.4701 0.0393 1.1432 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 352: 92.2069 -5.8103 -0.0718 2.3906 -0.9381 0.1380 3.1626 0.3623 0.4154 0.1570 1.4701 0.0393 1.1425 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 353: 92.2058 -5.8107 -0.0714 2.3913 -0.9381 0.1382 3.1629 0.3624 0.4154 0.1570 1.4695 0.0394 1.1426 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 354: 92.2046 -5.8102 -0.0710 2.3921 -0.9381 0.1384 3.1576 0.3624 0.4154 0.1571 1.4691 0.0394 1.1424 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 355: 92.2034 -5.8084 -0.0707 2.3928 -0.9381 0.1388 3.1501 0.3624 0.4154 0.1570 1.4686 0.0395 1.1414 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 356: 92.2027 -5.8079 -0.0703 2.3935 -0.9382 0.1392 3.1463 0.3626 0.4155 0.1569 1.4682 0.0396 1.1405 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 357: 92.2019 -5.8084 -0.0698 2.3943 -0.9382 0.1390 3.1444 0.3628 0.4156 0.1569 1.4665 0.0397 1.1403 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 358: 92.2014 -5.8085 -0.0694 2.3950 -0.9381 0.1389 3.1413 0.3630 0.4158 0.1569 1.4662 0.0398 1.1398 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 359: 92.2005 -5.8091 -0.0689 2.3956 -0.9383 0.1387 3.1393 0.3633 0.4159 0.1570 1.4664 0.0398 1.1401 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 360: 92.1994 -5.8091 -0.0685 2.3962 -0.9385 0.1385 3.1362 0.3635 0.4159 0.1572 1.4664 0.0398 1.1413 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 361: 92.1983 -5.8094 -0.0682 2.3966 -0.9386 0.1384 3.1340 0.3638 0.4159 0.1573 1.4669 0.0398 1.1420 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 362: 92.1976 -5.8086 -0.0678 2.3971 -0.9389 0.1380 3.1277 0.3639 0.4160 0.1573 1.4671 0.0398 1.1414 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 363: 92.1967 -5.8081 -0.0675 2.3976 -0.9389 0.1377 3.1239 0.3641 0.4161 0.1573 1.4669 0.0399 1.1412 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 364: 92.1960 -5.8073 -0.0671 2.3982 -0.9390 0.1373 3.1208 0.3643 0.4161 0.1572 1.4668 0.0399 1.1411 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 365: 92.1958 -5.8066 -0.0667 2.3988 -0.9389 0.1369 3.1164 0.3645 0.4160 0.1572 1.4672 0.0399 1.1416 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 366: 92.1956 -5.8063 -0.0664 2.3992 -0.9390 0.1364 3.1127 0.3650 0.4156 0.1573 1.4674 0.0399 1.1425 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 367: 92.1952 -5.8056 -0.0661 2.3996 -0.9389 0.1361 3.1082 0.3652 0.4155 0.1574 1.4675 0.0399 1.1416 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 368: 92.1948 -5.8059 -0.0658 2.4001 -0.9389 0.1359 3.1068 0.3655 0.4154 0.1575 1.4671 0.0399 1.1406 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 369: 92.1948 -5.8064 -0.0655 2.4005 -0.9388 0.1360 3.1055 0.3658 0.4152 0.1576 1.4669 0.0399 1.1408 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 370: 92.1951 -5.8072 -0.0652 2.4010 -0.9389 0.1361 3.1060 0.3660 0.4151 0.1576 1.4669 0.0399 1.1406 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 371: 92.1956 -5.8080 -0.0649 2.4015 -0.9390 0.1362 3.1095 0.3662 0.4150 0.1576 1.4669 0.0400 1.1411 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 372: 92.1962 -5.8096 -0.0645 2.4020 -0.9390 0.1363 3.1168 0.3665 0.4149 0.1576 1.4667 0.0400 1.1411 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 373: 92.1968 -5.8098 -0.0642 2.4025 -0.9392 0.1363 3.1154 0.3666 0.4147 0.1576 1.4664 0.0400 1.1418 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 374: 92.1972 -5.8098 -0.0640 2.4029 -0.9395 0.1363 3.1117 0.3667 0.4146 0.1576 1.4661 0.0401 1.1421 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 375: 92.1979 -5.8101 -0.0637 2.4032 -0.9397 0.1364 3.1090 0.3668 0.4143 0.1577 1.4654 0.0401 1.1425 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 376: 92.1981 -5.8106 -0.0635 2.4035 -0.9399 0.1363 3.1084 0.3669 0.4142 0.1576 1.4650 0.0401 1.1423 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 377: 92.1986 -5.8104 -0.0633 2.4039 -0.9399 0.1360 3.1053 0.3670 0.4142 0.1576 1.4645 0.0402 1.1424 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 378: 92.1989 -5.8104 -0.0631 2.4043 -0.9399 0.1358 3.1026 0.3671 0.4142 0.1577 1.4638 0.0402 1.1421 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 379: 92.1990 -5.8114 -0.0628 2.4047 -0.9399 0.1355 3.1068 0.3671 0.4141 0.1577 1.4636 0.0402 1.1413 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 380: 92.1989 -5.8119 -0.0627 2.4048 -0.9400 0.1351 3.1095 0.3673 0.4136 0.1577 1.4634 0.0402 1.1413 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 381: 92.1989 -5.8127 -0.0627 2.4048 -0.9400 0.1349 3.1152 0.3676 0.4131 0.1577 1.4631 0.0403 1.1408 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 382: 92.1994 -5.8126 -0.0627 2.4049 -0.9399 0.1348 3.1188 0.3678 0.4126 0.1576 1.4635 0.0403 1.1403 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 383: 92.2000 -5.8129 -0.0626 2.4049 -0.9397 0.1346 3.1256 0.3681 0.4120 0.1576 1.4637 0.0403 1.1396 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 384: 92.2006 -5.8133 -0.0626 2.4050 -0.9396 0.1347 3.1290 0.3683 0.4115 0.1575 1.4641 0.0402 1.1389 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 385: 92.2015 -5.8131 -0.0626 2.4050 -0.9394 0.1350 3.1287 0.3686 0.4110 0.1575 1.4642 0.0402 1.1382 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 386: 92.2023 -5.8140 -0.0625 2.4049 -0.9391 0.1349 3.1324 0.3690 0.4104 0.1574 1.4647 0.0402 1.1374 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 387: 92.2030 -5.8147 -0.0625 2.4050 -0.9390 0.1349 3.1345 0.3693 0.4099 0.1572 1.4652 0.0402 1.1366 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 388: 92.2040 -5.8157 -0.0625 2.4050 -0.9389 0.1349 3.1381 0.3696 0.4094 0.1570 1.4652 0.0402 1.1362 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 389: 92.2051 -5.8156 -0.0625 2.4051 -0.9387 0.1349 3.1373 0.3699 0.4090 0.1570 1.4653 0.0402 1.1354 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 390: 92.2063 -5.8152 -0.0625 2.4051 -0.9386 0.1349 3.1350 0.3702 0.4087 0.1570 1.4655 0.0402 1.1345 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 391: 92.2076 -5.8160 -0.0625 2.4051 -0.9384 0.1350 3.1380 0.3705 0.4083 0.1571 1.4656 0.0402 1.1341 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 392: 92.2086 -5.8166 -0.0626 2.4049 -0.9384 0.1349 3.1397 0.3707 0.4081 0.1572 1.4658 0.0402 1.1345 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 393: 92.2095 -5.8168 -0.0626 2.4047 -0.9383 0.1348 3.1405 0.3708 0.4080 0.1573 1.4659 0.0402 1.1344 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 394: 92.2107 -5.8174 -0.0627 2.4045 -0.9382 0.1347 3.1433 0.3710 0.4079 0.1575 1.4660 0.0401 1.1342 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 395: 92.2118 -5.8174 -0.0628 2.4043 -0.9380 0.1346 3.1437 0.3711 0.4078 0.1575 1.4661 0.0401 1.1343 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 396: 92.2127 -5.8170 -0.0629 2.4041 -0.9379 0.1344 3.1424 0.3712 0.4077 0.1575 1.4664 0.0401 1.1342 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 397: 92.2137 -5.8161 -0.0630 2.4040 -0.9376 0.1342 3.1386 0.3713 0.4076 0.1577 1.4667 0.0401 1.1341 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 398: 92.2146 -5.8152 -0.0633 2.4036 -0.9374 0.1341 3.1344 0.3713 0.4075 0.1578 1.4671 0.0401 1.1334 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 399: 92.2157 -5.8138 -0.0635 2.4032 -0.9373 0.1340 3.1296 0.3714 0.4074 0.1578 1.4678 0.0401 1.1336 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 400: 92.2165 -5.8131 -0.0638 2.4027 -0.9372 0.1340 3.1262 0.3715 0.4072 0.1579 1.4681 0.0400 1.1332 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 401: 92.2173 -5.8118 -0.0641 2.4022 -0.9372 0.1341 3.1220 0.3716 0.4069 0.1579 1.4686 0.0400 1.1339 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 402: 92.2181 -5.8107 -0.0643 2.4018 -0.9370 0.1344 3.1192 0.3718 0.4065 0.1580 1.4694 0.0400 1.1338 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 403: 92.2190 -5.8099 -0.0646 2.4013 -0.9371 0.1348 3.1166 0.3720 0.4061 0.1581 1.4700 0.0400 1.1344 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 404: 92.2198 -5.8104 -0.0649 2.4008 -0.9372 0.1348 3.1161 0.3723 0.4058 0.1582 1.4704 0.0399 1.1357 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 405: 92.2203 -5.8107 -0.0652 2.4004 -0.9372 0.1348 3.1177 0.3725 0.4055 0.1582 1.4705 0.0400 1.1358 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 406: 92.2204 -5.8103 -0.0653 2.4002 -0.9371 0.1348 3.1157 0.3724 0.4051 0.1582 1.4709 0.0400 1.1361 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 407: 92.2201 -5.8094 -0.0655 2.4001 -0.9369 0.1348 3.1121 0.3724 0.4048 0.1583 1.4713 0.0400 1.1360 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 408: 92.2201 -5.8087 -0.0657 2.3999 -0.9368 0.1350 3.1085 0.3724 0.4044 0.1582 1.4714 0.0400 1.1360 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 409: 92.2201 -5.8083 -0.0658 2.3998 -0.9365 0.1355 3.1073 0.3724 0.4043 0.1582 1.4713 0.0401 1.1358 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 410: 92.2196 -5.8094 -0.0659 2.3996 -0.9365 0.1361 3.1123 0.3724 0.4041 0.1582 1.4712 0.0401 1.1357 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 411: 92.2192 -5.8099 -0.0661 2.3994 -0.9366 0.1363 3.1168 0.3724 0.4038 0.1582 1.4715 0.0401 1.1354 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 412: 92.2187 -5.8105 -0.0662 2.3993 -0.9365 0.1365 3.1215 0.3725 0.4035 0.1582 1.4716 0.0401 1.1359 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 413: 92.2185 -5.8109 -0.0663 2.3992 -0.9365 0.1367 3.1268 0.3725 0.4031 0.1583 1.4719 0.0401 1.1357 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 414: 92.2183 -5.8111 -0.0665 2.3987 -0.9365 0.1370 3.1286 0.3727 0.4026 0.1582 1.4724 0.0400 1.1349 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 415: 92.2181 -5.8122 -0.0667 2.3983 -0.9366 0.1370 3.1351 0.3729 0.4021 0.1581 1.4726 0.0400 1.1341 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 416: 92.2180 -5.8133 -0.0669 2.3979 -0.9367 0.1372 3.1409 0.3731 0.4015 0.1578 1.4734 0.0400 1.1333 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 417: 92.2176 -5.8138 -0.0671 2.3976 -0.9368 0.1374 3.1426 0.3733 0.4009 0.1576 1.4739 0.0400 1.1325 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 418: 92.2173 -5.8150 -0.0673 2.3973 -0.9369 0.1376 3.1479 0.3735 0.4003 0.1575 1.4740 0.0400 1.1316 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 419: 92.2174 -5.8154 -0.0674 2.3970 -0.9369 0.1375 3.1497 0.3736 0.3998 0.1574 1.4741 0.0400 1.1314 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 420: 92.2175 -5.8154 -0.0676 2.3968 -0.9369 0.1375 3.1489 0.3737 0.3993 0.1574 1.4742 0.0400 1.1315 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 421: 92.2176 -5.8154 -0.0678 2.3964 -0.9369 0.1374 3.1485 0.3739 0.3989 0.1573 1.4743 0.0400 1.1312 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 422: 92.2174 -5.8155 -0.0680 2.3961 -0.9370 0.1375 3.1483 0.3741 0.3985 0.1572 1.4744 0.0400 1.1309 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 423: 92.2170 -5.8156 -0.0681 2.3958 -0.9371 0.1375 3.1481 0.3742 0.3980 0.1571 1.4741 0.0400 1.1308 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 424: 92.2169 -5.8168 -0.0683 2.3956 -0.9372 0.1374 3.1524 0.3744 0.3976 0.1571 1.4740 0.0400 1.1316 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 425: 92.2167 -5.8171 -0.0685 2.3954 -0.9372 0.1373 3.1520 0.3744 0.3972 0.1571 1.4736 0.0401 1.1317 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 426: 92.2164 -5.8170 -0.0687 2.3951 -0.9372 0.1373 3.1502 0.3745 0.3968 0.1570 1.4734 0.0401 1.1320 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 427: 92.2166 -5.8169 -0.0688 2.3949 -0.9372 0.1372 3.1480 0.3745 0.3964 0.1570 1.4734 0.0401 1.1317 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 428: 92.2166 -5.8170 -0.0689 2.3948 -0.9374 0.1371 3.1460 0.3745 0.3959 0.1570 1.4735 0.0401 1.1315 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 429: 92.2162 -5.8171 -0.0691 2.3946 -0.9374 0.1369 3.1446 0.3745 0.3954 0.1570 1.4736 0.0401 1.1316 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 430: 92.2158 -5.8178 -0.0692 2.3944 -0.9375 0.1370 3.1464 0.3745 0.3950 0.1570 1.4736 0.0401 1.1314 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 431: 92.2153 -5.8180 -0.0693 2.3942 -0.9375 0.1371 3.1470 0.3745 0.3946 0.1570 1.4735 0.0401 1.1314 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 432: 92.2150 -5.8182 -0.0695 2.3940 -0.9375 0.1372 3.1477 0.3746 0.3942 0.1570 1.4735 0.0401 1.1315 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 433: 92.2145 -5.8189 -0.0696 2.3938 -0.9375 0.1374 3.1512 0.3746 0.3938 0.1571 1.4736 0.0400 1.1323 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 434: 92.2141 -5.8186 -0.0697 2.3936 -0.9373 0.1376 3.1530 0.3746 0.3933 0.1571 1.4736 0.0400 1.1330 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 435: 92.2133 -5.8187 -0.0699 2.3934 -0.9373 0.1381 3.1571 0.3747 0.3929 0.1570 1.4738 0.0400 1.1325 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 436: 92.2129 -5.8180 -0.0700 2.3932 -0.9374 0.1380 3.1544 0.3746 0.3925 0.1570 1.4740 0.0400 1.1332 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 437: 92.2122 -5.8186 -0.0702 2.3930 -0.9375 0.1380 3.1574 0.3746 0.3921 0.1570 1.4739 0.0400 1.1342 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 438: 92.2114 -5.8187 -0.0703 2.3928 -0.9376 0.1380 3.1583 0.3745 0.3918 0.1569 1.4740 0.0400 1.1346 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 439: 92.2104 -5.8181 -0.0705 2.3925 -0.9377 0.1381 3.1568 0.3744 0.3914 0.1568 1.4743 0.0400 1.1352 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 440: 92.2095 -5.8178 -0.0706 2.3923 -0.9377 0.1381 3.1555 0.3743 0.3910 0.1566 1.4745 0.0400 1.1349 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 441: 92.2088 -5.8176 -0.0707 2.3923 -0.9378 0.1381 3.1559 0.3742 0.3907 0.1565 1.4748 0.0400 1.1349 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 442: 92.2081 -5.8172 -0.0708 2.3921 -0.9379 0.1383 3.1539 0.3741 0.3903 0.1564 1.4754 0.0400 1.1350 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 443: 92.2074 -5.8171 -0.0709 2.3920 -0.9380 0.1387 3.1526 0.3740 0.3901 0.1563 1.4756 0.0400 1.1349 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 444: 92.2068 -5.8175 -0.0711 2.3918 -0.9380 0.1390 3.1533 0.3739 0.3898 0.1562 1.4758 0.0400 1.1353 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 445: 92.2061 -5.8180 -0.0712 2.3915 -0.9382 0.1394 3.1529 0.3737 0.3896 0.1562 1.4758 0.0400 1.1355 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 446: 92.2054 -5.8177 -0.0714 2.3912 -0.9384 0.1398 3.1496 0.3735 0.3894 0.1562 1.4760 0.0399 1.1367 0.0716</span> -<span class="r-out co"><span class="r-pr">#></span> 447: 92.2051 -5.8180 -0.0716 2.3910 -0.9385 0.1400 3.1484 0.3734 0.3891 0.1563 1.4762 0.0399 1.1370 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 448: 92.2053 -5.8189 -0.0717 2.3909 -0.9387 0.1405 3.1499 0.3732 0.3889 0.1563 1.4764 0.0399 1.1377 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 449: 92.2054 -5.8195 -0.0718 2.3908 -0.9388 0.1411 3.1497 0.3730 0.3887 0.1562 1.4768 0.0399 1.1382 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 450: 92.2054 -5.8205 -0.0719 2.3906 -0.9390 0.1417 3.1528 0.3728 0.3885 0.1562 1.4769 0.0399 1.1378 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 451: 92.2053 -5.8213 -0.0720 2.3905 -0.9391 0.1423 3.1544 0.3725 0.3883 0.1561 1.4774 0.0399 1.1379 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 452: 92.2054 -5.8218 -0.0720 2.3905 -0.9393 0.1426 3.1541 0.3722 0.3882 0.1560 1.4779 0.0398 1.1378 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 453: 92.2054 -5.8217 -0.0721 2.3903 -0.9395 0.1428 3.1530 0.3721 0.3880 0.1559 1.4785 0.0398 1.1378 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 454: 92.2053 -5.8214 -0.0722 2.3901 -0.9395 0.1431 3.1508 0.3720 0.3878 0.1559 1.4786 0.0398 1.1375 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 455: 92.2052 -5.8220 -0.0724 2.3898 -0.9396 0.1433 3.1519 0.3720 0.3875 0.1559 1.4791 0.0398 1.1379 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 456: 92.2053 -5.8230 -0.0727 2.3894 -0.9397 0.1434 3.1544 0.3720 0.3873 0.1560 1.4793 0.0398 1.1384 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 457: 92.2053 -5.8240 -0.0729 2.3889 -0.9398 0.1437 3.1568 0.3720 0.3869 0.1559 1.4793 0.0398 1.1393 0.0714</span> -<span class="r-out co"><span class="r-pr">#></span> 458: 92.2051 -5.8245 -0.0731 2.3885 -0.9399 0.1440 3.1571 0.3721 0.3865 0.1558 1.4797 0.0397 1.1404 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 459: 92.2045 -5.8246 -0.0732 2.3882 -0.9402 0.1442 3.1562 0.3721 0.3862 0.1558 1.4801 0.0397 1.1407 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 460: 92.2040 -5.8244 -0.0734 2.3878 -0.9403 0.1442 3.1536 0.3722 0.3859 0.1558 1.4806 0.0397 1.1406 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 461: 92.2030 -5.8245 -0.0736 2.3874 -0.9404 0.1444 3.1517 0.3722 0.3856 0.1557 1.4811 0.0397 1.1412 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 462: 92.2022 -5.8253 -0.0738 2.3870 -0.9405 0.1445 3.1531 0.3723 0.3853 0.1556 1.4817 0.0396 1.1425 0.0712</span> -<span class="r-out co"><span class="r-pr">#></span> 463: 92.2014 -5.8260 -0.0740 2.3866 -0.9405 0.1449 3.1545 0.3724 0.3849 0.1556 1.4823 0.0396 1.1441 0.0711</span> -<span class="r-out co"><span class="r-pr">#></span> 464: 92.2008 -5.8257 -0.0742 2.3862 -0.9405 0.1453 3.1522 0.3726 0.3845 0.1555 1.4828 0.0396 1.1451 0.0711</span> -<span class="r-out co"><span class="r-pr">#></span> 465: 92.2002 -5.8256 -0.0744 2.3859 -0.9404 0.1458 3.1511 0.3727 0.3842 0.1555 1.4830 0.0396 1.1459 0.0710</span> -<span class="r-out co"><span class="r-pr">#></span> 466: 92.1997 -5.8256 -0.0747 2.3855 -0.9403 0.1463 3.1516 0.3728 0.3839 0.1555 1.4834 0.0396 1.1476 0.0709</span> -<span class="r-out co"><span class="r-pr">#></span> 467: 92.1993 -5.8258 -0.0749 2.3850 -0.9404 0.1468 3.1521 0.3730 0.3836 0.1555 1.4835 0.0395 1.1490 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 468: 92.1990 -5.8259 -0.0752 2.3846 -0.9404 0.1473 3.1546 0.3731 0.3834 0.1555 1.4837 0.0395 1.1500 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 469: 92.1987 -5.8263 -0.0753 2.3844 -0.9403 0.1479 3.1598 0.3731 0.3831 0.1555 1.4839 0.0395 1.1504 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 470: 92.1987 -5.8267 -0.0755 2.3841 -0.9403 0.1482 3.1611 0.3730 0.3829 0.1555 1.4839 0.0395 1.1496 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 471: 92.1987 -5.8269 -0.0756 2.3839 -0.9404 0.1482 3.1627 0.3730 0.3826 0.1555 1.4839 0.0395 1.1492 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 472: 92.1983 -5.8269 -0.0758 2.3838 -0.9403 0.1480 3.1618 0.3729 0.3823 0.1555 1.4839 0.0395 1.1493 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 473: 92.1980 -5.8264 -0.0760 2.3836 -0.9402 0.1478 3.1602 0.3728 0.3820 0.1554 1.4839 0.0395 1.1489 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 474: 92.1976 -5.8256 -0.0762 2.3834 -0.9402 0.1475 3.1565 0.3727 0.3818 0.1554 1.4842 0.0395 1.1487 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 475: 92.1971 -5.8252 -0.0763 2.3832 -0.9402 0.1473 3.1543 0.3726 0.3816 0.1553 1.4845 0.0395 1.1487 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 476: 92.1965 -5.8250 -0.0765 2.3830 -0.9402 0.1469 3.1523 0.3725 0.3814 0.1552 1.4846 0.0395 1.1484 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 477: 92.1960 -5.8242 -0.0766 2.3827 -0.9402 0.1465 3.1483 0.3724 0.3811 0.1552 1.4849 0.0395 1.1483 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 478: 92.1955 -5.8236 -0.0767 2.3826 -0.9402 0.1463 3.1447 0.3722 0.3808 0.1553 1.4854 0.0395 1.1481 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 479: 92.1952 -5.8232 -0.0769 2.3824 -0.9401 0.1462 3.1421 0.3722 0.3805 0.1554 1.4857 0.0395 1.1478 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 480: 92.1948 -5.8235 -0.0770 2.3822 -0.9400 0.1461 3.1426 0.3721 0.3803 0.1554 1.4862 0.0395 1.1478 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 481: 92.1947 -5.8240 -0.0772 2.3820 -0.9399 0.1459 3.1455 0.3721 0.3801 0.1554 1.4868 0.0395 1.1483 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 482: 92.1948 -5.8244 -0.0774 2.3817 -0.9399 0.1456 3.1476 0.3720 0.3799 0.1553 1.4873 0.0395 1.1488 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 483: 92.1944 -5.8247 -0.0776 2.3815 -0.9397 0.1455 3.1487 0.3719 0.3797 0.1553 1.4876 0.0394 1.1494 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 484: 92.1941 -5.8249 -0.0778 2.3811 -0.9396 0.1454 3.1493 0.3719 0.3795 0.1554 1.4879 0.0394 1.1501 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 485: 92.1940 -5.8252 -0.0780 2.3809 -0.9396 0.1453 3.1501 0.3718 0.3793 0.1554 1.4881 0.0394 1.1503 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 486: 92.1936 -5.8249 -0.0781 2.3807 -0.9395 0.1453 3.1486 0.3717 0.3792 0.1554 1.4884 0.0394 1.1508 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 487: 92.1935 -5.8248 -0.0783 2.3804 -0.9394 0.1453 3.1485 0.3716 0.3791 0.1553 1.4887 0.0393 1.1507 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 488: 92.1932 -5.8246 -0.0785 2.3800 -0.9394 0.1454 3.1478 0.3715 0.3788 0.1552 1.4892 0.0393 1.1510 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 489: 92.1931 -5.8241 -0.0787 2.3796 -0.9394 0.1455 3.1468 0.3715 0.3787 0.1551 1.4895 0.0393 1.1514 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 490: 92.1934 -5.8242 -0.0790 2.3793 -0.9393 0.1456 3.1478 0.3715 0.3786 0.1551 1.4898 0.0393 1.1528 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 491: 92.1936 -5.8241 -0.0792 2.3788 -0.9392 0.1455 3.1472 0.3715 0.3785 0.1551 1.4900 0.0393 1.1533 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 492: 92.1940 -5.8234 -0.0794 2.3783 -0.9391 0.1455 3.1449 0.3714 0.3783 0.1551 1.4903 0.0392 1.1538 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 493: 92.1943 -5.8230 -0.0797 2.3779 -0.9390 0.1455 3.1426 0.3714 0.3783 0.1552 1.4907 0.0392 1.1541 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 494: 92.1946 -5.8226 -0.0799 2.3774 -0.9390 0.1458 3.1405 0.3713 0.3782 0.1551 1.4911 0.0392 1.1541 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 495: 92.1948 -5.8219 -0.0802 2.3770 -0.9391 0.1459 3.1366 0.3712 0.3782 0.1551 1.4916 0.0392 1.1543 0.0706</span> -<span class="r-out co"><span class="r-pr">#></span> 496: 92.1948 -5.8213 -0.0804 2.3766 -0.9392 0.1460 3.1331 0.3711 0.3781 0.1552 1.4920 0.0392 1.1556 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 497: 92.1949 -5.8213 -0.0806 2.3762 -0.9393 0.1462 3.1326 0.3711 0.3780 0.1553 1.4923 0.0391 1.1564 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 498: 92.1950 -5.8215 -0.0808 2.3758 -0.9394 0.1462 3.1331 0.3710 0.3779 0.1553 1.4926 0.0391 1.1568 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 499: 92.1953 -5.8219 -0.0810 2.3754 -0.9395 0.1461 3.1343 0.3709 0.3778 0.1554 1.4929 0.0391 1.1567 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 500: 92.1957 -5.8232 -0.0812 2.3751 -0.9395 0.1459 3.1411 0.3709 0.3776 0.1554 1.4931 0.0391 1.1575 0.0705</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"FOMC-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_alpha |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_beta |sigma_low_parent |rsd_high_parent |sigma_low_A1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................|rsd_high_A1 | o1 | o2 | o3 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o4 | o5 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 500.20030 | 1.000 | -1.000 | -0.9113 | -0.8944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8678 | -0.8916 | -0.8678 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8916 | -0.8767 | -0.8743 | -0.8675 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8704 | -0.8704 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 500.2003 | 93.00 | -5.300 | -0.9400 | -0.1100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.200 | 0.03000 | 1.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03000 | 0.7598 | 0.8758 | 1.214 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 | 1.071 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 500.2003</span> | 93.00 | 0.004992 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.200 | 0.03000 | 1.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03000 | 0.7598 | 0.8758 | 1.214 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.068 | 1.071 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | 48.88 | 2.383 | 0.1231 | 0.1986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1571 | -68.85 | -20.11 | 3.616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.292 | 0.6250 | 11.41 | -12.48 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.903 | -10.91 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 2737.7532 | 0.4556 | -1.027 | -0.9127 | -0.8966 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8471 | -0.1009 | -0.6676 | -0.9080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8660 | -0.8837 | -1.001 | -0.7285 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7601 | -0.7489 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 2737.7532 | 42.37 | -5.327 | -0.9413 | -0.1122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.298 | 1.660 | 0.03336 | 1.176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03038 | 0.7545 | 0.7645 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.185 | 1.201 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 2737.7532</span> | 42.37 | 0.004861 | 0.2806 | 0.8939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.957 | 1.660 | 0.03336 | 1.176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03038 | 0.7545 | 0.7645 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.185 | 1.201 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 513.07755 | 0.9456 | -1.003 | -0.9114 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7911 | -0.8692 | -0.8718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8890 | -0.8774 | -0.8871 | -0.8536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8594 | -0.8582 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 513.07755 | 87.94 | -5.303 | -0.9401 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.246 | 0.03034 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7593 | 0.8646 | 1.231 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.079 | 1.084 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 513.07755</span> | 87.94 | 0.004978 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.972 | 1.246 | 0.03034 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7593 | 0.8646 | 1.231 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.079 | 1.084 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 499.28604 | 0.9888 | -1.001 | -0.9113 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8520 | -0.8870 | -0.8686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8910 | -0.8769 | -0.8770 | -0.8646 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8682 | -0.8679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 499.28604 | 91.96 | -5.301 | -0.9400 | -0.1100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.209 | 0.03007 | 1.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7597 | 0.8735 | 1.218 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.070 | 1.074 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 499.28604</span> | 91.96 | 0.004989 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.209 | 0.03007 | 1.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7597 | 0.8735 | 1.218 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.070 | 1.074 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -111.5 | 2.236 | -0.2057 | 0.1035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1971 | -66.17 | -21.17 | 4.107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.586 | 1.583 | 8.991 | -11.70 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.625 | -10.49 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 497.76004 | 1.001 | -1.001 | -0.9113 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8366 | -0.8822 | -0.8695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8906 | -0.8771 | -0.8792 | -0.8619 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8660 | -0.8654 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 497.76004 | 93.05 | -5.301 | -0.9400 | -0.1101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.219 | 0.03014 | 1.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7595 | 0.8715 | 1.221 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.072 | 1.076 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 497.76004</span> | 93.05 | 0.004986 | 0.2809 | 0.8958 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.219 | 0.03014 | 1.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03001 | 0.7595 | 0.8715 | 1.221 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.072 | 1.076 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 56.91 | 2.356 | 0.1468 | 0.2109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1761 | -64.61 | -18.67 | 3.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.680 | 1.108 | 8.338 | -11.70 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.518 | -10.47 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 496.73820 | 0.9899 | -1.002 | -0.9113 | -0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8205 | -0.8775 | -0.8703 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8902 | -0.8774 | -0.8813 | -0.8590 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8636 | -0.8628 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 496.7382 | 92.06 | -5.302 | -0.9400 | -0.1101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.228 | 0.03021 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03002 | 0.7593 | 0.8696 | 1.225 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.075 | 1.079 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.7382</span> | 92.06 | 0.004983 | 0.2809 | 0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.228 | 0.03021 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03002 | 0.7593 | 0.8696 | 1.225 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.075 | 1.079 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -94.52 | 2.222 | -0.1721 | 0.1131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1712 | -62.76 | -19.55 | 3.974 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.718 | 1.304 | 7.360 | -11.47 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.402 | -10.21 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 495.33979 | 1.001 | -1.002 | -0.9113 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.8044 | -0.8726 | -0.8713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8897 | -0.8777 | -0.8834 | -0.8560 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8612 | -0.8602 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.33979 | 93.05 | -5.302 | -0.9400 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.238 | 0.03028 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7591 | 0.8679 | 1.228 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.077 | 1.082 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.33979</span> | 93.05 | 0.004981 | 0.2809 | 0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.238 | 0.03028 | 1.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7591 | 0.8679 | 1.228 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.077 | 1.082 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 56.11 | 2.327 | 0.1520 | 0.2091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1742 | -61.13 | -17.23 | 3.435 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.620 | 1.132 | 9.399 | -11.44 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.328 | -10.19 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 494.31617 | 0.9904 | -1.003 | -0.9113 | -0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7881 | -0.8680 | -0.8722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | -0.8780 | -0.8859 | -0.8530 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8587 | -0.8575 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.31617 | 92.11 | -5.303 | -0.9400 | -0.1102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.248 | 0.03035 | 1.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7589 | 0.8657 | 1.232 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.085 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.31617</span> | 92.11 | 0.004977 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.248 | 0.03035 | 1.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03003 | 0.7589 | 0.8657 | 1.232 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.080 | 1.085 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -86.81 | 2.198 | -0.1566 | 0.1238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1638 | -59.37 | -18.02 | 4.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.591 | 1.325 | 8.479 | -11.19 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.201 | -9.937 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 493.00423 | 1.001 | -1.003 | -0.9113 | -0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.7718 | -0.8631 | -0.8732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8888 | -0.8783 | -0.8883 | -0.8499 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8562 | -0.8548 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 493.00423 | 93.05 | -5.303 | -0.9400 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.258 | 0.03043 | 1.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7586 | 0.8635 | 1.236 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.083 | 1.088 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.00423</span> | 93.05 | 0.004974 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.258 | 0.03043 | 1.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03004 | 0.7586 | 0.8635 | 1.236 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.083 | 1.088 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.84 | 2.286 | 0.1404 | 0.2142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1628 | -57.96 | -15.94 | 3.372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.642 | 1.184 | 9.036 | -11.17 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.110 | -9.901 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 491.99601 | 0.9908 | -1.004 | -0.9114 | -0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7552 | -0.8585 | -0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8884 | -0.8786 | -0.8910 | -0.8467 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8536 | -0.8520 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.99601 | 92.15 | -5.304 | -0.9401 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.268 | 0.03050 | 1.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03005 | 0.7584 | 0.8612 | 1.239 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.085 | 1.091 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.99601</span> | 92.15 | 0.004971 | 0.2809 | 0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.268 | 0.03050 | 1.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03005 | 0.7584 | 0.8612 | 1.239 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.085 | 1.091 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -80.67 | 2.171 | -0.1367 | 0.1256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1610 | -56.13 | -16.61 | 4.047 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.607 | 1.226 | 8.142 | -10.92 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.982 | -9.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 490.76421 | 1.000 | -1.005 | -0.9113 | -0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7388 | -0.8538 | -0.8754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8879 | -0.8790 | -0.8935 | -0.8435 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8510 | -0.8492 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.76421 | 93.04 | -5.305 | -0.9401 | -0.1104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.277 | 0.03057 | 1.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7581 | 0.8590 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.094 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.76421</span> | 93.04 | 0.004968 | 0.2809 | 0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.277 | 0.03057 | 1.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7581 | 0.8590 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.088 | 1.094 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.34 | 2.256 | 0.1715 | 0.2224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1653 | -54.87 | -14.72 | 3.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.777 | 1.023 | 8.651 | -10.90 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.887 | -9.594 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 489.76286 | 0.9913 | -1.005 | -0.9114 | -0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7220 | -0.8492 | -0.8764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8873 | -0.8793 | -0.8962 | -0.8402 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8483 | -0.8462 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 489.76286 | 92.19 | -5.305 | -0.9401 | -0.1104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.287 | 0.03063 | 1.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7579 | 0.8566 | 1.247 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 | 1.097 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.76286</span> | 92.19 | 0.004965 | 0.2809 | 0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.287 | 0.03063 | 1.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03006 | 0.7579 | 0.8566 | 1.247 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.091 | 1.097 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -73.18 | 2.145 | -0.1190 | 0.1261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1580 | -53.08 | -15.27 | 4.015 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.639 | 1.110 | 7.813 | -10.65 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.743 | -9.338 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 488.61493 | 1.000 | -1.006 | -0.9114 | -0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.7053 | -0.8446 | -0.8776 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8867 | -0.8796 | -0.8989 | -0.8368 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8455 | -0.8433 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.61493 | 93.04 | -5.306 | -0.9401 | -0.1105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.297 | 0.03070 | 1.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03007 | 0.7577 | 0.8543 | 1.252 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.094 | 1.100 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.61493</span> | 93.04 | 0.004961 | 0.2809 | 0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.297 | 0.03070 | 1.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03007 | 0.7577 | 0.8543 | 1.252 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.094 | 1.100 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 54.41 | 2.230 | 0.1889 | 0.2376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1637 | -52.01 | -13.54 | 3.223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.937 | 0.8847 | 10.07 | -10.59 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.650 | -9.282 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 487.61806 | 0.9919 | -1.007 | -0.9114 | -0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6884 | -0.8402 | -0.8788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8861 | -0.8798 | -0.9022 | -0.8333 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8427 | -0.8402 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.61806 | 92.24 | -5.307 | -0.9401 | -0.1105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.308 | 0.03077 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03008 | 0.7575 | 0.8514 | 1.256 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.097 | 1.103 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.61806</span> | 92.24 | 0.004958 | 0.2809 | 0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.308 | 0.03077 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03008 | 0.7575 | 0.8514 | 1.256 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.097 | 1.103 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -64.97 | 2.116 | -0.09941 | 0.1372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1475 | -50.35 | -14.02 | 3.916 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.790 | 0.8979 | 9.163 | -10.32 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.505 | -9.022 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 486.55968 | 1.001 | -1.008 | -0.9114 | -0.8950 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6717 | -0.8358 | -0.8800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8854 | -0.8801 | -0.9058 | -0.8297 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8398 | -0.8372 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 486.55968 | 93.05 | -5.308 | -0.9401 | -0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.318 | 0.03084 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03009 | 0.7573 | 0.8482 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.100 | 1.107 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.55968</span> | 93.05 | 0.004954 | 0.2809 | 0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.318 | 0.03084 | 1.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03009 | 0.7573 | 0.8482 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.100 | 1.107 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 55.08 | 2.188 | 0.1916 | 0.2341 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1660 | -48.95 | -12.27 | 3.347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.726 | 0.9589 | 6.446 | -10.30 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.390 | -8.950 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 485.60262 | 0.9920 | -1.008 | -0.9115 | -0.8951 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6547 | -0.8316 | -0.8813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8847 | -0.8804 | -0.9083 | -0.8260 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8367 | -0.8340 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.60262 | 92.26 | -5.308 | -0.9402 | -0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.328 | 0.03090 | 1.192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03010 | 0.7571 | 0.8460 | 1.265 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.104 | 1.110 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.60262</span> | 92.26 | 0.004950 | 0.2809 | 0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.328 | 0.03090 | 1.192 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03010 | 0.7571 | 0.8460 | 1.265 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.104 | 1.110 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -62.47 | 2.078 | -0.09882 | 0.1294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1587 | -47.42 | -12.81 | 3.926 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.683 | 0.9415 | 5.611 | -10.02 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.237 | -8.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 484.58535 | 1.000 | -1.009 | -0.9115 | -0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6375 | -0.8274 | -0.8829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8840 | -0.8807 | -0.9099 | -0.8222 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8336 | -0.8307 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.58535 | 93.02 | -5.309 | -0.9402 | -0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.338 | 0.03096 | 1.191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03011 | 0.7568 | 0.8446 | 1.269 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.114 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.58535</span> | 93.02 | 0.004946 | 0.2809 | 0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.338 | 0.03096 | 1.191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03011 | 0.7568 | 0.8446 | 1.269 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.107 | 1.114 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 50.15 | 2.155 | 0.1960 | 0.2225 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1509 | -46.14 | -11.19 | 3.405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.652 | 1.035 | 7.536 | -9.951 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.121 | -8.609 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 483.66860 | 0.9923 | -1.010 | -0.9115 | -0.8952 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6203 | -0.8235 | -0.8844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8833 | -0.8810 | -0.9123 | -0.8182 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8303 | -0.8273 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.6686 | 92.29 | -5.310 | -0.9402 | -0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.348 | 0.03102 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03012 | 0.7565 | 0.8425 | 1.274 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.117 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.6686</span> | 92.29 | 0.004942 | 0.2809 | 0.8951 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.348 | 0.03102 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03012 | 0.7565 | 0.8425 | 1.274 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.110 | 1.117 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -57.62 | 2.059 | -0.07549 | 0.1395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1501 | -44.74 | -11.66 | 3.913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.664 | 0.8845 | 6.781 | -9.703 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.961 | -8.325 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 482.71012 | 1.000 | -1.011 | -0.9115 | -0.8953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.6032 | -0.8198 | -0.8861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8825 | -0.8814 | -0.9153 | -0.8141 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8270 | -0.8239 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.71012 | 93.02 | -5.311 | -0.9402 | -0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.359 | 0.03108 | 1.189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03014 | 0.7563 | 0.8399 | 1.279 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.114 | 1.121 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.71012</span> | 93.02 | 0.004937 | 0.2809 | 0.8950 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.359 | 0.03108 | 1.189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03014 | 0.7563 | 0.8399 | 1.279 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.114 | 1.121 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.98 | 2.122 | 0.2043 | 0.2315 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1449 | -43.47 | -10.15 | 3.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.703 | 0.9582 | 7.160 | -9.600 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.838 | -8.245 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 481.83107 | 0.9926 | -1.012 | -0.9116 | -0.8954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5860 | -0.8164 | -0.8879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8817 | -0.8818 | -0.9184 | -0.8098 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8235 | -0.8203 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.83107 | 92.31 | -5.312 | -0.9403 | -0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.369 | 0.03113 | 1.188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03015 | 0.7560 | 0.8372 | 1.284 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.118 | 1.125 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.83107</span> | 92.31 | 0.004932 | 0.2808 | 0.8949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.369 | 0.03113 | 1.188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03015 | 0.7560 | 0.8372 | 1.284 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.118 | 1.125 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -54.27 | 2.027 | -0.06740 | 0.1414 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1465 | -41.84 | -10.48 | 3.798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.730 | 0.8044 | 6.401 | -9.335 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.662 | -7.960 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 480.92878 | 1.000 | -1.013 | -0.9117 | -0.8955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5689 | -0.8133 | -0.8899 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8807 | -0.8821 | -0.9215 | -0.8053 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8199 | -0.8166 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.92878 | 93.01 | -5.313 | -0.9403 | -0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.379 | 0.03117 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03016 | 0.7557 | 0.8345 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.122 | 1.129 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.92878</span> | 93.01 | 0.004927 | 0.2808 | 0.8948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.379 | 0.03117 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03016 | 0.7557 | 0.8345 | 1.290 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.122 | 1.129 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 47.18 | 2.077 | 0.1996 | 0.2200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1318 | -41.07 | -9.197 | 3.259 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.748 | 0.9101 | 6.743 | -9.229 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.511 | -7.855 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 480.07574 | 0.9930 | -1.014 | -0.9117 | -0.8956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8455 | -0.5517 | -0.8106 | -0.8919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8795 | -0.8825 | -0.9247 | -0.8007 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8161 | -0.8129 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.07574 | 92.35 | -5.314 | -0.9404 | -0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.390 | 0.03121 | 1.186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03018 | 0.7555 | 0.8317 | 1.295 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.126 | 1.133 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.07574</span> | 92.35 | 0.004921 | 0.2808 | 0.8947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.973 | 1.390 | 0.03121 | 1.186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03018 | 0.7555 | 0.8317 | 1.295 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.126 | 1.133 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.22 | 1.995 | -0.04658 | 0.1415 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1316 | -39.56 | -9.522 | 3.639 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.878 | 0.6154 | 4.556 | -8.937 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.320 | -7.563 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 479.25211 | 1.000 | -1.015 | -0.9118 | -0.8957 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.5343 | -0.8082 | -0.8940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8781 | -0.8826 | -0.9261 | -0.7958 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8122 | -0.8090 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.25211 | 93.02 | -5.315 | -0.9405 | -0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.400 | 0.03125 | 1.184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03020 | 0.7553 | 0.8305 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.130 | 1.137 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.25211</span> | 93.02 | 0.004915 | 0.2808 | 0.8946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.400 | 0.03125 | 1.184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03020 | 0.7553 | 0.8305 | 1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.130 | 1.137 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.39 | 2.048 | 0.2189 | 0.2175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1393 | -38.80 | -8.286 | 3.169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.757 | 0.9021 | 6.456 | -8.802 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.165 | -7.452 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 478.42395 | 0.9935 | -1.017 | -0.9119 | -0.8959 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.5169 | -0.8064 | -0.8963 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8766 | -0.8829 | -0.9277 | -0.7908 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8081 | -0.8051 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.42395 | 92.40 | -5.317 | -0.9406 | -0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.411 | 0.03128 | 1.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03022 | 0.7552 | 0.8290 | 1.307 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.134 | 1.141 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.42395</span> | 92.40 | 0.004909 | 0.2808 | 0.8945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.411 | 0.03128 | 1.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03022 | 0.7552 | 0.8290 | 1.307 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.134 | 1.141 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -41.65 | 1.977 | -0.02866 | 0.1453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1180 | -37.67 | -8.677 | 3.579 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.774 | 0.6894 | 5.855 | -8.506 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.962 | -7.153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 477.65816 | 1.000 | -1.018 | -0.9120 | -0.8960 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4997 | -0.8051 | -0.8988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8750 | -0.8832 | -0.9313 | -0.7859 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8042 | -0.8013 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.65816 | 93.02 | -5.318 | -0.9406 | -0.1116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.421 | 0.03130 | 1.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03025 | 0.7549 | 0.8259 | 1.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.138 | 1.145 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.65816</span> | 93.02 | 0.004901 | 0.2808 | 0.8944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.421 | 0.03130 | 1.181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03025 | 0.7549 | 0.8259 | 1.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.138 | 1.145 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 47.50 | 2.013 | 0.2278 | 0.2145 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1415 | -36.68 | -7.460 | 3.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.807 | 0.8669 | 6.124 | -8.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.814 | -7.074 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 476.87668 | 0.9936 | -1.020 | -0.9121 | -0.8962 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4825 | -0.8047 | -0.9014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8732 | -0.8836 | -0.9351 | -0.7808 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8001 | -0.7975 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.87668 | 92.41 | -5.320 | -0.9408 | -0.1117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.431 | 0.03130 | 1.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03028 | 0.7546 | 0.8226 | 1.319 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.143 | 1.149 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.87668</span> | 92.41 | 0.004893 | 0.2807 | 0.8943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.431 | 0.03130 | 1.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03028 | 0.7546 | 0.8226 | 1.319 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.143 | 1.149 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -40.64 | 1.935 | -0.02164 | 0.1511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1127 | -35.59 | -7.858 | 3.450 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.805 | 0.6731 | 3.945 | -8.048 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.589 | -6.756 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 476.16299 | 1.000 | -1.022 | -0.9123 | -0.8963 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4651 | -0.8047 | -0.9041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8711 | -0.8840 | -0.9355 | -0.7757 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7959 | -0.7936 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.16299 | 93.01 | -5.322 | -0.9409 | -0.1119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.442 | 0.03130 | 1.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03031 | 0.7543 | 0.8222 | 1.326 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.147 | 1.153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.16299</span> | 93.01 | 0.004885 | 0.2807 | 0.8941 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.442 | 0.03130 | 1.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03031 | 0.7543 | 0.8222 | 1.326 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.147 | 1.153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 44.38 | 1.982 | 0.2331 | 0.2213 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1467 | -34.64 | -6.709 | 2.894 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.888 | 0.7760 | 4.358 | -7.901 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.419 | -6.620 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 475.47434 | 0.9938 | -1.024 | -0.9125 | -0.8966 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4477 | -0.8058 | -0.9069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8685 | -0.8844 | -0.9328 | -0.7706 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7919 | -0.7898 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.47434 | 92.43 | -5.324 | -0.9411 | -0.1122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.452 | 0.03129 | 1.177 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03035 | 0.7540 | 0.8246 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.151 | 1.157 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.47434</span> | 92.43 | 0.004875 | 0.2807 | 0.8939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.452 | 0.03129 | 1.177 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03035 | 0.7540 | 0.8246 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.151 | 1.157 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -38.01 | 1.932 | -0.02542 | 0.1483 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1147 | -33.71 | -7.114 | 3.216 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.879 | 0.6267 | 4.067 | -7.573 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.213 | -6.338 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 474.82575 | 0.9998 | -1.026 | -0.9126 | -0.8968 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4303 | -0.8075 | -0.9096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8656 | -0.8846 | -0.9310 | -0.7657 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7878 | -0.7862 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.82575 | 92.98 | -5.326 | -0.9413 | -0.1124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.462 | 0.03126 | 1.175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03039 | 0.7538 | 0.8261 | 1.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.156 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.82575</span> | 92.98 | 0.004864 | 0.2806 | 0.8937 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.462 | 0.03126 | 1.175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03039 | 0.7538 | 0.8261 | 1.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.156 | 1.161 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.83 | 1.980 | 0.2123 | 0.2125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1324 | -32.65 | -6.032 | 2.979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.922 | 0.7692 | 4.596 | -7.426 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.058 | -6.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 474.18202 | 0.9939 | -1.028 | -0.9128 | -0.8971 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.4131 | -0.8106 | -0.9130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8620 | -0.8851 | -0.9307 | -0.7608 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7838 | -0.7828 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.18202 | 92.44 | -5.328 | -0.9414 | -0.1127 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.473 | 0.03121 | 1.173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03044 | 0.7535 | 0.8264 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.160 | 1.165 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.18202</span> | 92.44 | 0.004852 | 0.2806 | 0.8935 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.473 | 0.03121 | 1.173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03044 | 0.7535 | 0.8264 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.160 | 1.165 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -37.33 | 1.920 | -0.03157 | 0.1462 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1145 | -31.92 | -6.433 | 3.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.919 | 0.6114 | 5.640 | -7.155 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -5.876 | -5.958 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 473.55376 | 0.9995 | -1.031 | -0.9130 | -0.8973 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8454 | -0.3971 | -0.8148 | -0.9162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8581 | -0.8855 | -0.9368 | -0.7563 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7800 | -0.7797 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.55376 | 92.95 | -5.331 | -0.9416 | -0.1129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.482 | 0.03115 | 1.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03050 | 0.7531 | 0.8211 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.164 | 1.168 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.55376</span> | 92.95 | 0.004838 | 0.2806 | 0.8932 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.974 | 1.482 | 0.03115 | 1.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03050 | 0.7531 | 0.8211 | 1.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.164 | 1.168 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 472.90182 | 0.9995 | -1.035 | -0.9132 | -0.8977 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8453 | -0.3799 | -0.8225 | -0.9204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8527 | -0.8861 | -0.9447 | -0.7510 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7757 | -0.7763 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.90182 | 92.96 | -5.335 | -0.9418 | -0.1133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.493 | 0.03104 | 1.168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03058 | 0.7527 | 0.8141 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.169 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.90182</span> | 92.96 | 0.004819 | 0.2805 | 0.8929 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.975 | 1.493 | 0.03104 | 1.168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03058 | 0.7527 | 0.8141 | 1.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.169 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 469.90339 | 0.9997 | -1.054 | -0.9142 | -0.8996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8452 | -0.2944 | -0.8611 | -0.9412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8255 | -0.8889 | -0.9843 | -0.7249 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7539 | -0.7597 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.90339 | 92.98 | -5.354 | -0.9427 | -0.1152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.300 | 1.544 | 0.03046 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03099 | 0.7505 | 0.7794 | 1.387 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.192 | 1.190 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.90339</span> | 92.98 | 0.004727 | 0.2803 | 0.8912 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.976 | 1.544 | 0.03046 | 1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03099 | 0.7505 | 0.7794 | 1.387 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.192 | 1.190 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 461.71523 | 1.001 | -1.134 | -0.9184 | -0.9072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8447 | 0.05742 | -1.020 | -1.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7136 | -0.9005 | -1.147 | -0.6175 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6642 | -0.6913 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 461.71523 | 93.05 | -5.434 | -0.9467 | -0.1228 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.301 | 1.755 | 0.02808 | 1.105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03267 | 0.7417 | 0.6368 | 1.518 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.288 | 1.263 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 461.71523</span> | 93.05 | 0.004366 | 0.2795 | 0.8844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.981 | 1.755 | 0.02808 | 1.105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03267 | 0.7417 | 0.6368 | 1.518 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.288 | 1.263 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.20 | 1.045 | 1.020 | 0.3495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7923 | -15.00 | -0.3969 | -1.315 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -3.031 | 0.2676 | -6.780 | -1.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.09081 | -1.463 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 459.94653 | 1.009 | -1.206 | -0.9768 | -0.9283 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8884 | 0.4547 | -1.238 | -0.9419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5030 | -0.9080 | -0.7892 | -0.6450 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7313 | -0.6959 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 459.94653 | 93.85 | -5.506 | -1.002 | -0.1439 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.257 | 1.993 | 0.02480 | 1.155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03583 | 0.7361 | 0.9504 | 1.484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.216 | 1.258 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 459.94653</span> | 93.85 | 0.004064 | 0.2686 | 0.8660 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.554 | 1.993 | 0.02480 | 1.155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03583 | 0.7361 | 0.9504 | 1.484 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.216 | 1.258 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 117.0 | 1.389 | -1.721 | -0.1200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.004314 | -5.763 | 2.093 | 3.426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.378 | 2.600 | 15.14 | -1.236 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -4.018 | -1.529 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 458.11528 | 1.003 | -1.307 | -0.9477 | -0.9422 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9430 | 0.6906 | -1.630 | -0.8850 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1864 | -1.043 | -0.8947 | -0.8359 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7822 | -0.7759 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 458.11528 | 93.30 | -5.607 | -0.9742 | -0.1578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.202 | 2.135 | 0.01893 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04058 | 0.6334 | 0.8579 | 1.253 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.162 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 458.11528</span> | 93.30 | 0.003671 | 0.2740 | 0.8540 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.046 | 2.135 | 0.01893 | 1.190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04058 | 0.6334 | 0.8579 | 1.253 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.162 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.502 | 0.8367 | -0.1865 | -0.1361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6555 | -2.945 | 1.425 | 8.523 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6882 | -2.700 | 7.982 | -9.961 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.514 | -5.474 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 454.42202 | 1.008 | -1.411 | -0.9501 | -0.9563 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9900 | 0.8215 | -2.099 | -1.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1520 | -1.049 | -0.9274 | -0.7533 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7158 | -0.7241 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 454.42202 | 93.74 | -5.711 | -0.9765 | -0.1719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.155 | 2.214 | 0.01188 | 1.102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04565 | 0.6287 | 0.8293 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.233 | 1.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.42202</span> | 93.74 | 0.003311 | 0.2736 | 0.8421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.631 | 2.214 | 0.01188 | 1.102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.04565 | 0.6287 | 0.8293 | 1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.233 | 1.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 451.48622 | 1.000 | -1.659 | -0.9551 | -0.9914 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.111 | 1.029 | -2.892 | -1.353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9897 | -1.076 | -0.9627 | -0.6147 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5957 | -0.6379 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 451.48622 | 93.01 | -5.959 | -0.9812 | -0.2070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.035 | 2.338 | 5.960e-07 | 0.9088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05822 | 0.6083 | 0.7984 | 1.521 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.361 | 1.320 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 451.48622</span> | 93.01 | 0.002583 | 0.2727 | 0.8130 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 7.651 | 2.338 | 5.960e-07 | 0.9088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05822 | 0.6083 | 0.7984 | 1.521 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.361 | 1.320 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -68.34 | 0.03355 | 0.09905 | -1.306 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.058 | -1.204 | -0.09883 | -1.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.726 | -4.145 | 7.646 | -0.5743 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.003 | 2.613 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 453.25472 | 1.003 | -2.027 | -1.069 | -0.8933 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6960 | 1.084 | -2.892 | -1.695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.689 | -0.4882 | -1.206 | -0.2814 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7545 | -0.8496 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 453.25472 | 93.31 | -6.327 | -1.089 | -0.1089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.449 | 2.371 | 5.960e-07 | 0.7037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08370 | 1.055 | 0.5857 | 1.926 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.191 | 1.093 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 453.25472</span> | 93.31 | 0.001787 | 0.2519 | 0.8968 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 11.58 | 2.371 | 5.960e-07 | 0.7037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08370 | 1.055 | 0.5857 | 1.926 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.191 | 1.093 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 449.59369 | 1.000 | -1.818 | -1.010 | -0.9508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.052 | -2.892 | -1.498 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8175 | -1.073 | -0.4671 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6691 | -0.7270 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 449.59369 | 93.04 | -6.118 | -1.033 | -0.1664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.960e-07 | 0.8216 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8048 | 0.7021 | 1.700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.282 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.59369</span> | 93.04 | 0.002202 | 0.2625 | 0.8467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.960e-07 | 0.8216 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8048 | 0.7021 | 1.700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.282 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -128.1 | 0.1096 | -3.510 | -0.1773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1823 | -1.358 | -0.002263 | 1.313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.294 | 5.530 | 5.100 | 4.831 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.292 | -3.851 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 472.13387 | 1.020 | -1.985 | -0.7592 | -0.7822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2976 | 1.062 | -2.892 | -1.866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.141 | -0.7519 | -1.136 | -0.6405 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7706 | -0.2153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.13387 | 94.83 | -6.285 | -0.7970 | 0.002176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.848 | 2.358 | 5.960e-07 | 0.6009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09049 | 0.8547 | 0.6467 | 1.490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.174 | 1.773 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.13387</span> | 94.83 | 0.001864 | 0.3107 | 1.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 17.25 | 2.358 | 5.960e-07 | 0.6009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09049 | 0.8547 | 0.6467 | 1.490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.174 | 1.773 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 454.13083 | 1.030 | -1.841 | -0.9756 | -0.9280 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8501 | 1.054 | -2.892 | -1.548 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.921 | -0.8098 | -1.082 | -0.4916 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6825 | -0.6571 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 454.13083 | 95.82 | -6.141 | -1.000 | -0.1436 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.295 | 2.353 | 5.960e-07 | 0.7917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07219 | 0.8106 | 0.6936 | 1.671 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.299 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.13083</span> | 95.82 | 0.002153 | 0.2688 | 0.8663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.927 | 2.353 | 5.960e-07 | 0.7917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07219 | 0.8106 | 0.6936 | 1.671 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.299 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 454.81886 | 1.032 | -1.823 | -1.002 | -0.9459 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9179 | 1.053 | -2.892 | -1.509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.771 | -0.8169 | -1.076 | -0.4733 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6717 | -0.7113 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 454.81886 | 95.94 | -6.123 | -1.025 | -0.1614 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.227 | 2.352 | 5.960e-07 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06994 | 0.8052 | 0.6994 | 1.693 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.280 | 1.241 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 454.81886</span> | 95.94 | 0.002192 | 0.2640 | 0.8509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.277 | 2.352 | 5.960e-07 | 0.8150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06994 | 0.8052 | 0.6994 | 1.693 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.280 | 1.241 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 449.57011 | 1.014 | -1.818 | -1.010 | -0.9508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.053 | -2.892 | -1.499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8181 | -1.073 | -0.4676 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6690 | -0.7267 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 449.57011 | 94.27 | -6.118 | -1.033 | -0.1664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.995e-07 | 0.8215 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8044 | 0.7016 | 1.700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.57011</span> | 94.27 | 0.002202 | 0.2626 | 0.8467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.995e-07 | 0.8215 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8044 | 0.7016 | 1.700 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 126.9 | 0.1582 | -2.201 | 0.05331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4695 | -0.6265 | 0.01503 | 0.4241 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.337 | 5.854 | 6.688 | 4.536 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.410 | -4.016 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 449.14922 | 1.007 | -1.818 | -1.010 | -0.9508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | 1.053 | -2.892 | -1.499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | -0.8183 | -1.074 | -0.4678 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6689 | -0.7265 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 449.14922 | 93.66 | -6.118 | -1.033 | -0.1664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.352 | 5.960e-07 | 0.8215 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8042 | 0.7014 | 1.699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.14922</span> | 93.66 | 0.002202 | 0.2626 | 0.8467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.106 | 2.352 | 5.960e-07 | 0.8215 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06933 | 0.8042 | 0.7014 | 1.699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.283 | 1.225 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.4066 | 0.1367 | -2.828 | -0.06013 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1445 | -0.8286 | 0.01677 | 0.9213 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.224 | 4.943 | 4.017 | 5.223 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.311 | -3.922 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 449.08136 | 1.007 | -1.818 | -1.008 | -0.9507 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9365 | 1.053 | -2.892 | -1.499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.731 | -0.8217 | -1.076 | -0.4714 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6680 | -0.7238 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 449.08136 | 93.68 | -6.118 | -1.031 | -0.1663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.353 | 5.960e-07 | 0.8212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06934 | 0.8016 | 0.6990 | 1.695 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.284 | 1.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 449.08136</span> | 93.68 | 0.002202 | 0.2629 | 0.8468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.353 | 5.960e-07 | 0.8212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06934 | 0.8016 | 0.6990 | 1.695 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.284 | 1.228 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 448.89872 | 1.008 | -1.819 | -1.002 | -0.9506 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9368 | 1.055 | -2.892 | -1.501 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.734 | -0.8317 | -1.084 | -0.4820 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6654 | -0.7159 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 448.89872 | 93.76 | -6.119 | -1.025 | -0.1662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.354 | 5.960e-07 | 0.8200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06938 | 0.7940 | 0.6918 | 1.682 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.286 | 1.237 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.89872</span> | 93.76 | 0.002202 | 0.2640 | 0.8469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.102 | 2.354 | 5.960e-07 | 0.8200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06938 | 0.7940 | 0.6918 | 1.682 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.286 | 1.237 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 448.46351 | 1.011 | -1.820 | -0.9792 | -0.9501 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9380 | 1.062 | -2.892 | -1.509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.744 | -0.8718 | -1.117 | -0.5244 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6547 | -0.6840 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 448.46351 | 94.07 | -6.120 | -1.004 | -0.1657 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.207 | 2.358 | 5.960e-07 | 0.8155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06953 | 0.7635 | 0.6633 | 1.631 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 | 1.271 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.46351</span> | 94.07 | 0.002199 | 0.2682 | 0.8473 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.092 | 2.358 | 5.960e-07 | 0.8155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06953 | 0.7635 | 0.6633 | 1.631 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.298 | 1.271 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 75.37 | 0.2597 | -0.1569 | 0.03608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3501 | -0.3601 | -0.01324 | 0.5025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.327 | 4.308 | 0.9122 | 2.456 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5631 | -1.887 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 448.12149 | 1.008 | -1.833 | -0.9950 | -0.9378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8937 | 1.062 | -2.892 | -1.543 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.827 | -0.8899 | -1.115 | -0.5324 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6574 | -0.6703 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 448.12149 | 93.73 | -6.133 | -1.019 | -0.1534 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.252 | 2.358 | 5.960e-07 | 0.7948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07077 | 0.7498 | 0.6653 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.295 | 1.285 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 448.12149</span> | 93.73 | 0.002169 | 0.2653 | 0.8578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.504 | 2.358 | 5.960e-07 | 0.7948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07077 | 0.7498 | 0.6653 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.295 | 1.285 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.78 | 0.2222 | -1.381 | 0.2569 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.259 | -0.5740 | -0.02850 | 0.1620 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.241 | 3.503 | 0.9893 | 2.205 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7124 | -1.054 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 447.94443 | 1.007 | -1.844 | -0.9902 | -0.9390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9059 | 1.062 | -2.881 | -1.561 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.911 | -0.9357 | -1.119 | -0.5167 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6474 | -0.7008 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.94443 | 93.62 | -6.144 | -1.014 | -0.1546 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.239 | 2.358 | 0.0001615 | 0.7838 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07204 | 0.7150 | 0.6617 | 1.640 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.306 | 1.253 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.94443</span> | 93.62 | 0.002146 | 0.2662 | 0.8567 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.388 | 2.358 | 0.0001615 | 0.7838 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07204 | 0.7150 | 0.6617 | 1.640 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.306 | 1.253 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.879 | 0.2071 | -1.215 | 0.2527 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8228 | -0.5096 | -0.06036 | 0.4983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.183 | 1.766 | 2.266 | 2.617 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3179 | -2.389 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 447.77390 | 1.007 | -1.858 | -1.003 | -0.9470 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9285 | 1.056 | -2.855 | -1.583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.006 | -0.9406 | -1.128 | -0.5198 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6539 | -0.6964 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.7739 | 93.69 | -6.158 | -1.026 | -0.1626 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 2.354 | 0.0005494 | 0.7710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07347 | 0.7113 | 0.6533 | 1.636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.299 | 1.257 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.7739</span> | 93.69 | 0.002117 | 0.2639 | 0.8500 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.179 | 2.354 | 0.0005494 | 0.7710 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07347 | 0.7113 | 0.6533 | 1.636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.299 | 1.257 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 447.56301 | 1.006 | -1.897 | -1.041 | -0.9708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9958 | 1.039 | -2.777 | -1.647 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.291 | -0.9540 | -1.156 | -0.5273 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6737 | -0.6848 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.56301 | 93.51 | -6.197 | -1.061 | -0.1864 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.150 | 2.344 | 0.001717 | 0.7326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07774 | 0.7011 | 0.6293 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.278 | 1.270 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.56301</span> | 93.51 | 0.002035 | 0.2570 | 0.8300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.581 | 2.344 | 0.001717 | 0.7326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07774 | 0.7011 | 0.6293 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.278 | 1.270 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.60 | 0.2182 | -4.075 | -0.4855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.237 | -0.6626 | -0.1062 | 0.6612 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | 1.074 | 1.318 | 2.279 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -1.614 | -1.745 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 447.16930 | 1.007 | -1.971 | -0.9627 | -0.9652 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9709 | 1.044 | -2.781 | -1.732 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.691 | -0.9472 | -1.156 | -0.5162 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6828 | -0.6632 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.1693 | 93.67 | -6.271 | -0.9883 | -0.1807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.174 | 2.347 | 0.001652 | 0.6812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08374 | 0.7063 | 0.6288 | 1.641 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.1693</span> | 93.67 | 0.001890 | 0.2713 | 0.8346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.798 | 2.347 | 0.001652 | 0.6812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08374 | 0.7063 | 0.6288 | 1.641 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.268 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.693 | 0.1048 | 0.8560 | -0.3278 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6115 | -0.5188 | -0.09596 | 0.9789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.02585 | 1.094 | 1.548 | 2.318 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -2.079 | -0.9259 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 447.68852 | 1.013 | -2.042 | -1.008 | -0.9421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9288 | 1.034 | -2.709 | -1.852 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.037 | -0.9368 | -1.153 | -0.6162 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5399 | -0.6984 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.68852 | 94.21 | -6.342 | -1.031 | -0.1577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.217 | 2.341 | 0.002735 | 0.6094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08893 | 0.7142 | 0.6313 | 1.519 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.420 | 1.255 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.68852</span> | 94.21 | 0.001761 | 0.2629 | 0.8541 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.176 | 2.341 | 0.002735 | 0.6094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08893 | 0.7142 | 0.6313 | 1.519 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.420 | 1.255 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 447.15405 | 1.011 | -1.991 | -0.9760 | -0.9584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9586 | 1.042 | -2.761 | -1.767 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.789 | -0.9450 | -1.157 | -0.5460 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6410 | -0.6726 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.15405 | 94.04 | -6.291 | -1.001 | -0.1740 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.187 | 2.346 | 0.001959 | 0.6605 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08521 | 0.7080 | 0.6287 | 1.605 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.312 | 1.283 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.15405</span> | 94.04 | 0.001852 | 0.2688 | 0.8403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.906 | 2.346 | 0.001959 | 0.6605 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08521 | 0.7080 | 0.6287 | 1.605 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.312 | 1.283 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 53.59 | 0.07914 | 0.2662 | -0.1234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1097 | -0.6518 | -0.06086 | 0.6193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05679 | 1.445 | 0.6511 | 1.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1794 | -1.326 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 447.09915 | 1.005 | -2.002 | -0.9768 | -0.9545 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9567 | 1.042 | -2.752 | -1.789 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.838 | -0.9392 | -1.155 | -0.5617 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6261 | -0.6787 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.09915 | 93.47 | -6.302 | -1.002 | -0.1701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.189 | 2.346 | 0.002096 | 0.6471 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08594 | 0.7123 | 0.6298 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.328 | 1.276 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.09915</span> | 93.47 | 0.001833 | 0.2686 | 0.8436 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 8.923 | 2.346 | 0.002096 | 0.6471 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08594 | 0.7123 | 0.6298 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.328 | 1.276 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.97 | 0.05091 | -0.1219 | -0.09607 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3249 | -0.8735 | -0.1278 | 0.5888 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06635 | 1.636 | -1.923 | 0.5172 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.5270 | -1.419 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 447.01951 | 1.007 | -2.009 | -0.9874 | -0.9450 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9329 | 1.053 | -2.780 | -1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.841 | -0.9693 | -1.155 | -0.5556 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6514 | -0.6721 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.01951 | 93.64 | -6.309 | -1.012 | -0.1606 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.212 | 2.352 | 0.001680 | 0.6361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08598 | 0.6895 | 0.6300 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.301 | 1.283 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.01951</span> | 93.64 | 0.001820 | 0.2667 | 0.8517 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.138 | 2.352 | 0.001680 | 0.6361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08598 | 0.6895 | 0.6300 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.301 | 1.283 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.500 | 0.04518 | -0.6412 | 0.1616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3106 | -0.6054 | -0.07873 | -0.1077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1002 | 0.2460 | 1.553 | 0.4490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8245 | -1.132 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 447.04861 | 1.009 | -2.019 | -0.9927 | -0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9252 | 1.054 | -2.796 | -1.779 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.878 | -0.9737 | -1.157 | -0.5487 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6291 | -0.6521 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.04861 | 93.85 | -6.319 | -1.017 | -0.1632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.220 | 2.353 | 0.001429 | 0.6532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08654 | 0.6862 | 0.6280 | 1.601 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.325 | 1.305 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.04861</span> | 93.85 | 0.001802 | 0.2657 | 0.8494 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.209 | 2.353 | 0.001429 | 0.6532 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08654 | 0.6862 | 0.6280 | 1.601 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.325 | 1.305 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 447.01937 | 1.009 | -2.012 | -0.9891 | -0.9459 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9304 | 1.053 | -2.785 | -1.798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.853 | -0.9708 | -1.156 | -0.5534 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6439 | -0.6653 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.01937 | 93.80 | -6.312 | -1.013 | -0.1615 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.215 | 2.353 | 0.001597 | 0.6418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08617 | 0.6884 | 0.6292 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.309 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.01937</span> | 93.80 | 0.001814 | 0.2664 | 0.8509 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.161 | 2.353 | 0.001597 | 0.6418 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08617 | 0.6884 | 0.6292 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.309 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.62 | 0.04451 | -0.6370 | 0.1658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4720 | -0.4967 | -0.06076 | 0.2478 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.07878 | 0.2929 | 0.7908 | 0.7364 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2169 | -0.8458 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 447.00331 | 1.007 | -2.016 | -0.9874 | -0.9487 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9321 | 1.057 | -2.790 | -1.800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.856 | -0.9696 | -1.156 | -0.5575 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6423 | -0.6633 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 447.00331 | 93.68 | -6.316 | -1.012 | -0.1643 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.213 | 2.355 | 0.001526 | 0.6406 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08622 | 0.6893 | 0.6295 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 447.00331</span> | 93.68 | 0.001807 | 0.2667 | 0.8485 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.146 | 2.355 | 0.001526 | 0.6406 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08622 | 0.6893 | 0.6295 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.749 | 0.03581 | -0.6032 | 0.06997 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3775 | -0.4012 | -0.08782 | 0.2553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.001918 | 0.1783 | 1.513 | 0.3567 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3333 | -0.7379 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 446.99944 | 1.008 | -2.018 | -0.9851 | -0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9359 | 1.058 | -2.787 | -1.806 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.859 | -0.9671 | -1.156 | -0.5614 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6427 | -0.6650 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 446.99944 | 93.70 | -6.318 | -1.009 | -0.1632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.355 | 0.001564 | 0.6369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08626 | 0.6911 | 0.6291 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99944</span> | 93.70 | 0.001804 | 0.2671 | 0.8494 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.111 | 2.355 | 0.001564 | 0.6369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08626 | 0.6911 | 0.6291 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.474 | 0.03546 | -0.4554 | 0.1057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2777 | -0.4692 | -0.06549 | 0.06429 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09650 | 0.2331 | 0.6150 | 0.1626 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3753 | -0.8072 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 446.99641 | 1.007 | -2.020 | -0.9846 | -0.9460 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9366 | 1.059 | -2.790 | -1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.868 | -0.9676 | -1.156 | -0.5621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6420 | -0.6633 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 446.99641 | 93.67 | -6.320 | -1.009 | -0.1616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.356 | 0.001530 | 0.6356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99641</span> | 93.67 | 0.001800 | 0.2672 | 0.8508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.356 | 0.001530 | 0.6356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.070 | 0.03317 | -0.4443 | 0.1488 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2478 | -0.4968 | -0.07674 | 0.09423 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05318 | 0.2365 | 0.6058 | 0.5619 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3013 | -0.7224 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 446.99641 | 1.007 | -2.020 | -0.9846 | -0.9460 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9366 | 1.059 | -2.790 | -1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.868 | -0.9676 | -1.156 | -0.5621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6420 | -0.6633 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 446.99641 | 93.67 | -6.320 | -1.009 | -0.1616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.209 | 2.356 | 0.001530 | 0.6356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 446.99641</span> | 93.67 | 0.001800 | 0.2672 | 0.8508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 9.105 | 2.356 | 0.001530 | 0.6356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.08639 | 0.6908 | 0.6287 | 1.585 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.311 | 1.293 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"saem"</span>,</span> -<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> 1: 90.7519 -4.8586 -1.7674 -3.5599 -2.0059 0.5800 4.8899 1.4250 1.1400 2.6923 0.4845 0.4370 10.2815 0.0004 9.0437 0.4047</span> -<span class="r-out co"><span class="r-pr">#></span> 2: 9.0763e+01 -5.2004e+00 -1.9605e+00 -4.2009e+00 -1.8767e+00 2.0341e-01 4.6454e+00 1.3537e+00 1.0830e+00 2.7771e+00 4.6027e-01 5.1181e-01 6.3469e+00 4.0033e-04 6.8216e+00 9.0448e-05</span> -<span class="r-out co"><span class="r-pr">#></span> 3: 9.0656e+01 -5.4820e+00 -2.0937e+00 -4.0962e+00 -1.5381e+00 -1.7136e-02 4.4131e+00 1.2861e+00 1.0288e+00 3.5620e+00 4.3726e-01 6.1217e-01 4.8763e+00 4.1436e-05 5.4967e+00 1.0148e-05</span> -<span class="r-out co"><span class="r-pr">#></span> 4: 9.0543e+01 -5.7744e+00 -2.1074e+00 -4.0393e+00 -1.3603e+00 -2.3531e-01 5.0162e+00 1.2218e+00 1.0041e+00 3.3839e+00 4.1540e-01 5.8157e-01 4.1029e+00 2.1466e-04 4.2869e+00 1.9419e-06</span> -<span class="r-out co"><span class="r-pr">#></span> 5: 91.1621 -6.0534 -2.0430 -4.0508 -1.2523 -0.2043 6.1015 1.1715 1.1998 3.2147 0.3946 0.5525 3.5979 0.0187 3.8221 0.0271</span> -<span class="r-out co"><span class="r-pr">#></span> 6: 91.1179 -5.9892 -2.0082 -4.1363 -1.1428 -0.1930 5.7964 1.1960 1.2360 3.4525 0.3749 0.5293 3.3091 0.0209 3.6230 0.0284</span> -<span class="r-out co"><span class="r-pr">#></span> 7: 91.6680 -5.9609 -2.0492 -4.1163 -1.0919 -0.1505 5.6134 1.6750 1.3055 3.2799 0.3631 0.5028 3.2412 0.0254 3.5108 0.0371</span> -<span class="r-out co"><span class="r-pr">#></span> 8: 91.6903 -5.9346 -2.0630 -4.0790 -1.1130 -0.0963 5.3327 2.2525 1.3524 3.1159 0.3449 0.4777 2.6165 0.0445 2.8556 0.0576</span> -<span class="r-out co"><span class="r-pr">#></span> 9: 92.2564 -5.7600 -2.0460 -4.1144 -1.0635 -0.0594 5.9616 2.1399 1.2848 2.9601 0.3277 0.4538 2.3593 0.0295 2.5704 0.0491</span> -<span class="r-out co"><span class="r-pr">#></span> 10: 92.2425 -5.7990 -2.0052 -4.0409 -1.0387 -0.1141 6.9547 2.1239 1.2205 2.8121 0.3113 0.4311 2.3237 0.0323 2.4227 0.0421</span> -<span class="r-out co"><span class="r-pr">#></span> 11: 92.4404 -5.6829 -2.0866 -4.0010 -1.0214 -0.0587 6.6790 2.0177 1.1595 2.6715 0.2957 0.4096 1.9963 0.0407 2.2478 0.0501</span> -<span class="r-out co"><span class="r-pr">#></span> 12: 92.0713 -5.8051 -2.1699 -4.0539 -0.9807 0.0174 6.7885 2.1380 1.1811 2.6017 0.2810 0.3891 1.8480 0.0502 2.0516 0.0522</span> -<span class="r-out co"><span class="r-pr">#></span> 13: 91.7214 -5.6954 -2.1579 -4.0944 -0.9935 -0.0195 6.4491 2.0311 1.1221 2.4716 0.2669 0.3696 1.8299 0.0531 1.9271 0.0520</span> -<span class="r-out co"><span class="r-pr">#></span> 14: 91.1978 -5.6733 -2.1988 -4.0794 -0.9387 0.0091 6.1267 1.9295 1.1589 2.3480 0.2536 0.3511 1.6357 0.0470 1.8899 0.0639</span> -<span class="r-out co"><span class="r-pr">#></span> 15: 91.3746 -5.5864 -2.1484 -4.1356 -0.9126 0.0045 5.8203 1.8330 1.2078 2.3265 0.2409 0.3336 1.6218 0.0428 1.6558 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 16: 91.5646 -5.4931 -2.1474 -4.1242 -0.9148 0.0179 5.5293 1.7414 1.1474 2.2733 0.2288 0.3169 1.6467 0.0377 1.6977 0.0600</span> -<span class="r-out co"><span class="r-pr">#></span> 17: 91.4767 -5.5885 -2.1424 -4.1386 -0.9308 0.0602 5.2528 1.9428 1.2141 2.1762 0.2174 0.3343 1.4916 0.0424 1.4326 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 18: 90.9989 -5.6364 -2.1601 -4.1606 -0.9676 0.0694 4.9902 1.8457 1.2521 2.2899 0.2065 0.3279 1.4504 0.0471 1.4267 0.0700</span> -<span class="r-out co"><span class="r-pr">#></span> 19: 91.4050 -5.7347 -2.0985 -4.1476 -0.9656 0.0668 4.7407 2.3263 1.4064 2.2061 0.1962 0.3296 1.3679 0.0485 1.2735 0.0844</span> -<span class="r-out co"><span class="r-pr">#></span> 20: 91.2707 -5.7623 -2.1155 -4.1538 -0.9601 0.0425 4.5037 2.6509 1.3408 2.1958 0.1864 0.3576 1.3736 0.0452 1.3454 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 21: 91.6878 -5.8143 -2.1261 -4.1649 -0.9325 0.0333 4.7695 2.8996 1.3244 2.1300 0.1771 0.3509 1.4793 0.0508 1.0333 0.0839</span> -<span class="r-out co"><span class="r-pr">#></span> 22: 91.5363 -5.9047 -2.1358 -4.1655 -0.9207 0.0339 4.5310 3.4408 1.3022 2.1829 0.1682 0.3378 1.4260 0.0488 0.9436 0.0877</span> -<span class="r-out co"><span class="r-pr">#></span> 23: 91.9969 -5.9565 -2.1378 -4.1609 -0.9243 0.0701 4.3045 3.7239 1.3446 2.2424 0.1598 0.3209 1.4182 0.0412 0.9205 0.0873</span> -<span class="r-out co"><span class="r-pr">#></span> 24: 92.2835 -5.9272 -2.0883 -4.1651 -0.9248 0.0834 4.0892 3.7780 1.2773 2.2187 0.1518 0.3049 1.4749 0.0427 0.9837 0.0802</span> -<span class="r-out co"><span class="r-pr">#></span> 25: 92.3389 -6.1292 -2.1033 -4.2473 -0.9069 0.0593 3.8848 4.7059 1.2740 2.4323 0.1442 0.2896 1.3656 0.0493 0.9299 0.0798</span> -<span class="r-out co"><span class="r-pr">#></span> 26: 91.9840 -5.9821 -2.1124 -4.2150 -0.9100 0.1076 3.6905 4.4706 1.2103 2.4699 0.1458 0.2751 1.3200 0.0504 0.8256 0.0912</span> -<span class="r-out co"><span class="r-pr">#></span> 27: 92.4671 -5.8765 -2.0910 -4.2169 -0.9356 0.0483 3.5060 4.2471 1.2302 2.4791 0.1385 0.2614 1.4252 0.0520 0.8191 0.0836</span> -<span class="r-out co"><span class="r-pr">#></span> 28: 92.4130 -5.9480 -2.0870 -4.2191 -0.9338 0.0866 3.3859 4.1337 1.2210 2.4685 0.1412 0.2557 1.3860 0.0484 0.9189 0.0770</span> -<span class="r-out co"><span class="r-pr">#></span> 29: 92.3064 -5.7845 -2.0759 -4.2321 -0.9270 0.0855 4.2691 3.9271 1.3369 2.5457 0.1341 0.2922 1.3848 0.0513 0.9658 0.0785</span> -<span class="r-out co"><span class="r-pr">#></span> 30: 92.2109 -5.9347 -2.0725 -4.2042 -0.9074 0.0481 5.5659 3.9234 1.2701 2.4184 0.1370 0.2776 1.2925 0.0560 0.9058 0.0806</span> -<span class="r-out co"><span class="r-pr">#></span> 31: 91.8912 -5.7466 -2.0912 -4.1504 -0.9087 0.0443 5.2876 3.7272 1.2690 2.2975 0.1301 0.2637 1.3348 0.0517 0.8672 0.0840</span> -<span class="r-out co"><span class="r-pr">#></span> 32: 92.3866 -5.8560 -2.0979 -4.1547 -0.9044 0.0335 5.0232 3.5408 1.2761 2.3185 0.1307 0.2505 1.3558 0.0487 0.9422 0.0791</span> -<span class="r-out co"><span class="r-pr">#></span> 33: 92.4555 -5.6989 -2.0956 -4.1479 -0.9038 0.0447 4.7720 3.3638 1.3253 2.2962 0.1242 0.2380 1.4321 0.0432 0.8961 0.0799</span> -<span class="r-out co"><span class="r-pr">#></span> 34: 92.6307 -5.8831 -2.0769 -4.1319 -0.8946 0.0430 4.5334 3.7151 1.2785 2.2638 0.1201 0.2261 1.4076 0.0457 0.8269 0.0813</span> -<span class="r-out co"><span class="r-pr">#></span> 35: 92.5659 -5.9100 -2.0748 -4.1482 -0.9079 0.0563 4.6634 3.7452 1.3141 2.3378 0.1168 0.2148 1.3571 0.0451 0.8317 0.0831</span> -<span class="r-out co"><span class="r-pr">#></span> 36: 92.5738 -5.8574 -2.0981 -4.1214 -0.8963 0.0302 5.3272 3.7371 1.3359 2.2776 0.1331 0.2041 1.3308 0.0480 0.8953 0.0791</span> -<span class="r-out co"><span class="r-pr">#></span> 37: 92.1615 -5.7137 -2.0922 -4.1178 -0.9035 0.0455 5.4894 3.5503 1.2691 2.2508 0.1473 0.1939 1.3692 0.0495 0.9358 0.0800</span> -<span class="r-out co"><span class="r-pr">#></span> 38: 92.4421 -5.6978 -2.0905 -4.1275 -0.9052 0.0108 5.4295 3.3728 1.2057 2.2119 0.1432 0.1842 1.3421 0.0549 0.8932 0.0781</span> -<span class="r-out co"><span class="r-pr">#></span> 39: 92.3995 -5.6121 -2.0804 -4.1275 -0.8903 0.0270 5.1580 3.2041 1.1454 2.2119 0.1360 0.1978 1.3353 0.0524 0.9062 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 40: 92.5616 -5.7907 -2.1099 -4.1127 -0.9074 0.0501 4.9001 3.0439 1.1582 2.1723 0.1387 0.1879 1.2981 0.0510 0.9517 0.0797</span> -<span class="r-out co"><span class="r-pr">#></span> 41: 92.2655 -5.6532 -2.0631 -4.1437 -0.9128 0.0346 4.6551 2.8917 1.1202 2.1498 0.1403 0.1785 1.4500 0.0461 0.7394 0.0903</span> -<span class="r-out co"><span class="r-pr">#></span> 42: 92.3218 -5.4916 -2.1072 -4.1312 -0.9310 0.0360 4.4224 2.7471 1.1648 2.1428 0.1332 0.1695 1.4034 0.0508 0.8131 0.0854</span> -<span class="r-out co"><span class="r-pr">#></span> 43: 92.6165 -5.5145 -2.0838 -4.1239 -0.9215 0.0347 4.2012 2.6098 1.1892 2.1202 0.1463 0.1611 1.3416 0.0507 0.8213 0.0847</span> -<span class="r-out co"><span class="r-pr">#></span> 44: 92.5385 -5.5590 -2.0872 -4.1376 -0.9210 0.0672 3.9912 2.4793 1.1416 2.2253 0.1450 0.1530 1.4008 0.0352 0.8639 0.0847</span> -<span class="r-out co"><span class="r-pr">#></span> 45: 92.2152 -5.6170 -2.1014 -4.1657 -0.9331 0.0781 3.7916 2.4382 1.1250 2.2378 0.1516 0.1556 1.4612 0.0329 1.0091 0.0820</span> -<span class="r-out co"><span class="r-pr">#></span> 46: 91.8943 -5.6650 -2.1329 -4.1649 -0.9241 0.1060 3.6020 2.6448 1.0705 2.3112 0.1441 0.1549 1.5047 0.0384 1.0179 0.0805</span> -<span class="r-out co"><span class="r-pr">#></span> 47: 91.8153 -5.5910 -2.1514 -4.1919 -0.9169 0.0885 3.4219 2.5125 1.0386 2.3140 0.1506 0.1620 1.4759 0.0375 1.1021 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 48: 91.6295 -5.5438 -2.1516 -4.1570 -0.8742 0.0851 3.2508 2.3869 1.0816 2.1983 0.1630 0.1786 1.4024 0.0405 1.1135 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 49: 91.4363 -5.5847 -2.1732 -4.1794 -0.8634 0.0948 3.0883 2.4829 1.0865 2.2378 0.1549 0.1697 1.4314 0.0434 1.0529 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 50: 91.3634 -5.5794 -2.1613 -4.1507 -0.8849 0.0862 2.9339 2.6404 1.0829 2.2519 0.1493 0.1612 1.3704 0.0446 1.0081 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 51: 91.2150 -5.5503 -2.1675 -4.1432 -0.8749 0.1178 2.7872 2.7368 1.0605 2.2261 0.1418 0.1532 1.4312 0.0418 1.0380 0.0781</span> -<span class="r-out co"><span class="r-pr">#></span> 52: 91.4343 -5.6336 -2.2138 -4.1552 -0.8867 0.1391 2.6677 2.7022 1.0857 2.2588 0.1493 0.1455 1.3220 0.0469 0.9272 0.0761</span> -<span class="r-out co"><span class="r-pr">#></span> 53: 91.3310 -5.5185 -2.2340 -4.1430 -0.8855 0.1545 2.9130 2.5670 1.0720 2.3074 0.1532 0.1385 1.3224 0.0503 0.9688 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 54: 91.4342 -5.5008 -2.2086 -4.1777 -0.8720 0.1688 2.8202 2.4387 1.0624 2.4253 0.1631 0.1315 1.3186 0.0429 0.9425 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 55: 91.4983 -5.5944 -2.1709 -4.1211 -0.8638 0.1168 3.4789 2.5154 1.0549 2.3041 0.1557 0.1279 1.3800 0.0423 0.9620 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 56: 91.5954 -5.5317 -2.1881 -4.1263 -0.8627 0.1366 4.1396 2.3896 1.0732 2.2684 0.1562 0.1221 1.3285 0.0431 1.0156 0.0708</span> -<span class="r-out co"><span class="r-pr">#></span> 57: 91.6591 -5.3839 -2.2082 -4.1122 -0.8929 0.1457 4.5073 2.2701 1.0672 2.3639 0.1539 0.1160 1.4074 0.0478 0.9796 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 58: 91.7434 -5.3597 -2.2068 -4.1214 -0.8912 0.1437 4.2819 2.1566 1.0605 2.4496 0.1667 0.1109 1.4274 0.0450 1.0782 0.0676</span> -<span class="r-out co"><span class="r-pr">#></span> 59: 91.6597 -5.4672 -2.1918 -4.1412 -0.9021 0.1657 4.0678 2.0488 1.1306 2.5245 0.1888 0.1054 1.4745 0.0391 1.1492 0.0670</span> -<span class="r-out co"><span class="r-pr">#></span> 60: 91.7565 -5.4513 -2.2051 -4.1618 -0.9013 0.1554 3.8644 1.9464 1.1728 2.6191 0.1793 0.1001 1.4135 0.0402 1.1572 0.0665</span> -<span class="r-out co"><span class="r-pr">#></span> 61: 91.9484 -5.5390 -2.1973 -4.1611 -0.9011 0.1318 3.6712 1.8963 1.1460 2.6242 0.1704 0.0951 1.3855 0.0481 1.1109 0.0634</span> -<span class="r-out co"><span class="r-pr">#></span> 62: 92.1661 -5.4985 -2.1729 -4.1352 -0.8887 0.1327 4.3155 1.8588 1.1087 2.5551 0.1633 0.0995 1.3847 0.0444 1.0736 0.0656</span> -<span class="r-out co"><span class="r-pr">#></span> 63: 92.1727 -5.4086 -2.1610 -4.1488 -0.8998 0.1451 4.6019 1.7659 1.1413 2.6020 0.1718 0.1152 1.4299 0.0404 1.2202 0.0603</span> -<span class="r-out co"><span class="r-pr">#></span> 64: 92.4331 -5.5220 -2.1121 -4.1300 -0.9428 0.1211 5.0354 1.8121 1.0982 2.6157 0.1775 0.1209 1.4168 0.0348 1.2148 0.0625</span> -<span class="r-out co"><span class="r-pr">#></span> 65: 92.1871 -5.6089 -2.1258 -4.1412 -0.9127 0.1399 4.7836 2.1060 1.1568 2.5971 0.1757 0.1148 1.4000 0.0336 1.0305 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 66: 92.1419 -5.7752 -2.1344 -4.1493 -0.9237 0.1494 4.5444 2.7076 1.1563 2.6439 0.1740 0.1091 1.4238 0.0341 1.0285 0.0688</span> -<span class="r-out co"><span class="r-pr">#></span> 67: 92.1187 -5.5967 -2.1430 -4.1460 -0.9074 0.1245 4.3172 2.5722 1.2052 2.6139 0.1868 0.1104 1.4100 0.0381 1.0508 0.0703</span> -<span class="r-out co"><span class="r-pr">#></span> 68: 92.1123 -5.6882 -2.1481 -4.1269 -0.9083 0.1206 4.1014 2.5548 1.2021 2.4832 0.1781 0.1462 1.3099 0.0417 1.0099 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 69: 92.2511 -5.6923 -2.1456 -4.1315 -0.9077 0.1421 4.3551 2.6261 1.1850 2.3591 0.1692 0.1389 1.3546 0.0416 0.9516 0.0762</span> -<span class="r-out co"><span class="r-pr">#></span> 70: 92.0291 -5.7376 -2.1689 -4.1364 -0.8908 0.1407 4.1373 3.0520 1.1595 2.2495 0.1608 0.1465 1.3226 0.0436 0.9904 0.0711</span> -<span class="r-out co"><span class="r-pr">#></span> 71: 91.7690 -5.7223 -2.1773 -4.1986 -0.9036 0.1831 3.9304 2.8994 1.1015 2.4335 0.1527 0.1602 1.3135 0.0450 0.9564 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 72: 91.4802 -5.7302 -2.2079 -4.2000 -0.8990 0.2112 3.7339 3.2965 1.1222 2.4612 0.1451 0.1622 1.3222 0.0426 1.0215 0.0717</span> -<span class="r-out co"><span class="r-pr">#></span> 73: 91.1247 -5.7803 -2.1827 -4.2214 -0.8876 0.1385 3.5472 3.2786 1.1612 2.5216 0.1650 0.1541 1.2811 0.0493 1.0076 0.0696</span> -<span class="r-out co"><span class="r-pr">#></span> 74: 90.9765 -5.6534 -2.1808 -4.2511 -0.8824 0.1308 3.8553 3.1146 1.1389 2.8140 0.1725 0.1464 1.2895 0.0518 1.0100 0.0707</span> -<span class="r-out co"><span class="r-pr">#></span> 75: 90.4805 -5.7293 -2.1481 -4.2613 -0.8704 0.1395 4.1255 2.9589 1.1623 2.7523 0.1713 0.1391 1.3112 0.0483 0.9439 0.0788</span> -<span class="r-out co"><span class="r-pr">#></span> 76: 90.3958 -5.7635 -2.1508 -4.2426 -0.8841 0.1402 4.7427 3.0223 1.2187 2.7243 0.1789 0.1321 1.3065 0.0468 0.9303 0.0758</span> -<span class="r-out co"><span class="r-pr">#></span> 77: 90.7518 -5.6517 -2.1498 -4.2773 -0.8730 0.1688 5.9340 2.8712 1.1840 2.8530 0.1828 0.1255 1.3553 0.0422 0.9755 0.0696</span> -<span class="r-out co"><span class="r-pr">#></span> 78: 91.0443 -5.7462 -2.1351 -4.2601 -0.8848 0.1746 5.6373 2.9912 1.1312 2.7659 0.1887 0.1192 1.3303 0.0410 0.8578 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 79: 90.9631 -5.7307 -2.1618 -4.2593 -0.8965 0.1944 5.7520 3.1324 1.1206 2.8212 0.1875 0.1340 1.3519 0.0449 0.9006 0.0799</span> -<span class="r-out co"><span class="r-pr">#></span> 80: 90.8703 -5.7665 -2.1989 -4.2476 -0.9122 0.1933 5.4644 3.4527 1.1063 2.7920 0.1781 0.1273 1.3014 0.0497 0.9305 0.0792</span> -<span class="r-out co"><span class="r-pr">#></span> 81: 90.7781 -5.8702 -2.1789 -4.2821 -0.8828 0.1793 5.1912 3.7553 1.0662 3.0568 0.1807 0.1209 1.3120 0.0472 0.9808 0.0772</span> -<span class="r-out co"><span class="r-pr">#></span> 82: 90.8137 -6.1164 -2.2001 -4.3046 -0.8912 0.1916 4.9316 4.9023 1.0714 3.1363 0.1716 0.1149 1.2724 0.0539 1.0644 0.0693</span> -<span class="r-out co"><span class="r-pr">#></span> 83: 90.9900 -6.2077 -2.1695 -4.3121 -0.8924 0.1722 6.7123 5.3290 1.1120 3.2733 0.1741 0.1091 1.2822 0.0510 1.0142 0.0715</span> -<span class="r-out co"><span class="r-pr">#></span> 84: 90.8158 -6.3282 -2.1595 -4.2907 -0.9096 0.1818 6.3767 5.9725 1.1342 3.2384 0.1763 0.1037 1.2704 0.0420 0.8891 0.0834</span> -<span class="r-out co"><span class="r-pr">#></span> 85: 90.5926 -6.2052 -2.1643 -4.2780 -0.9000 0.1579 6.0579 5.6739 1.1472 3.0765 0.1751 0.0985 1.3263 0.0433 0.9484 0.0814</span> -<span class="r-out co"><span class="r-pr">#></span> 86: 90.3804 -6.2707 -2.1470 -4.2627 -0.9260 0.1650 5.7550 5.5542 1.1135 2.9227 0.1956 0.0936 1.2747 0.0447 0.9731 0.0780</span> -<span class="r-out co"><span class="r-pr">#></span> 87: 90.8425 -6.4455 -2.1135 -4.2273 -0.9294 0.1491 5.4672 6.8599 1.0716 2.7765 0.1858 0.0928 1.3204 0.0427 1.0005 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 88: 91.2019 -6.2302 -2.1362 -4.1982 -0.9333 0.1615 5.1939 6.5169 1.1221 2.7203 0.1841 0.0928 1.2689 0.0466 0.9914 0.0771</span> -<span class="r-out co"><span class="r-pr">#></span> 89: 90.9907 -6.4173 -2.1174 -4.2493 -0.9182 0.1628 4.9342 6.2408 1.1719 2.9614 0.1749 0.1021 1.3580 0.0403 1.0171 0.0775</span> -<span class="r-out co"><span class="r-pr">#></span> 90: 91.1666 -6.5154 -2.1219 -4.2011 -0.9210 0.1594 4.6875 7.4895 1.1930 2.8133 0.1745 0.0970 1.2500 0.0432 0.9467 0.0799</span> -<span class="r-out co"><span class="r-pr">#></span> 91: 91.0165 -6.5918 -2.1465 -4.2231 -0.9079 0.1382 4.9772 7.3172 1.1706 2.6789 0.1810 0.1032 1.2958 0.0458 1.1223 0.0639</span> -<span class="r-out co"><span class="r-pr">#></span> 92: 91.5386 -6.6567 -2.1376 -4.2247 -0.9358 0.1696 5.5955 7.4188 1.1543 2.6339 0.1754 0.0980 1.2894 0.0463 0.9927 0.0764</span> -<span class="r-out co"><span class="r-pr">#></span> 93: 92.2552 -6.5096 -2.1645 -4.2340 -0.9393 0.1798 5.3157 7.0479 1.1612 2.6312 0.1718 0.0931 1.3698 0.0431 1.2649 0.0579</span> -<span class="r-out co"><span class="r-pr">#></span> 94: 91.7588 -6.4124 -2.1795 -4.2305 -0.9265 0.1842 5.8275 6.6955 1.1988 2.6403 0.1891 0.0884 1.3022 0.0481 1.0741 0.0713</span> -<span class="r-out co"><span class="r-pr">#></span> 95: 91.6694 -6.2975 -2.1946 -4.2442 -0.9392 0.2004 5.5361 6.3607 1.1399 2.7164 0.1796 0.1027 1.2519 0.0513 1.0982 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 96: 91.2252 -6.0124 -2.2316 -4.2701 -0.8946 0.2375 5.2593 6.0427 1.0829 2.7921 0.2024 0.1147 1.3343 0.0426 1.3064 0.0560</span> -<span class="r-out co"><span class="r-pr">#></span> 97: 91.0388 -5.9178 -2.2563 -4.2703 -0.9093 0.2304 5.6825 5.7405 1.0890 2.7678 0.2113 0.1090 1.3517 0.0484 1.4160 0.0493</span> -<span class="r-out co"><span class="r-pr">#></span> 98: 90.9013 -6.1325 -2.2597 -4.2776 -0.9133 0.2447 5.7546 5.4535 1.1028 2.6806 0.2130 0.1182 1.2983 0.0451 1.2436 0.0584</span> -<span class="r-out co"><span class="r-pr">#></span> 99: 91.2086 -6.0047 -2.2719 -4.2972 -0.9136 0.2738 5.4668 5.1808 1.1776 2.7160 0.2132 0.1123 1.3301 0.0431 1.1850 0.0628</span> -<span class="r-out co"><span class="r-pr">#></span> 100: 91.3181 -5.9175 -2.2311 -4.3202 -0.8947 0.2844 5.1935 4.9218 1.1187 2.8660 0.2289 0.1471 1.3409 0.0371 0.9566 0.0806</span> -<span class="r-out co"><span class="r-pr">#></span> 101: 91.5112 -5.7721 -2.2292 -4.3060 -0.8842 0.3006 6.3617 4.6757 1.0628 2.7227 0.2174 0.1500 1.3269 0.0407 1.2002 0.0592</span> -<span class="r-out co"><span class="r-pr">#></span> 102: 91.5205 -5.9982 -2.2162 -4.3041 -0.8813 0.3065 7.7957 4.4419 1.0320 2.7176 0.2290 0.1474 1.3218 0.0392 0.9685 0.0783</span> -<span class="r-out co"><span class="r-pr">#></span> 103: 91.2416 -5.7012 -2.2204 -4.3198 -0.8610 0.3180 7.4059 4.2198 1.0242 2.5817 0.2175 0.1714 1.3003 0.0395 0.9472 0.0825</span> -<span class="r-out co"><span class="r-pr">#></span> 104: 91.2662 -5.8136 -2.2357 -4.3063 -0.8700 0.3110 7.0356 4.0088 1.0024 2.4701 0.2067 0.1939 1.2806 0.0407 1.0387 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 105: 91.4688 -5.7922 -2.2204 -4.3319 -0.8703 0.2767 6.6838 3.8084 0.9751 2.6368 0.1963 0.1967 1.3320 0.0470 1.2043 0.0580</span> -<span class="r-out co"><span class="r-pr">#></span> 106: 91.3665 -5.8505 -2.2225 -4.3614 -0.8757 0.2922 7.1982 3.6180 1.0018 2.6378 0.1865 0.2132 1.2613 0.0464 1.0683 0.0693</span> -<span class="r-out co"><span class="r-pr">#></span> 107: 91.4934 -5.8933 -2.1993 -4.3433 -0.9112 0.3267 6.8383 3.7379 0.9616 2.5329 0.1772 0.2169 1.2911 0.0449 1.0688 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 108: 92.1268 -5.7807 -2.1863 -4.4348 -0.9273 0.3235 6.4964 3.5510 1.0093 2.9025 0.1718 0.2061 1.3153 0.0414 0.8982 0.0796</span> -<span class="r-out co"><span class="r-pr">#></span> 109: 91.6585 -5.9778 -2.2083 -4.3550 -0.9061 0.3339 6.1715 4.5778 1.0600 2.7574 0.1755 0.2163 1.2754 0.0382 0.8100 0.0868</span> -<span class="r-out co"><span class="r-pr">#></span> 110: 92.0456 -5.6784 -2.2236 -4.3483 -0.8911 0.3022 5.8630 4.3489 1.0427 2.6195 0.1667 0.2472 1.3782 0.0336 0.7819 0.0931</span> -<span class="r-out co"><span class="r-pr">#></span> 111: 92.2862 -5.6624 -2.1985 -4.3680 -0.9178 0.3156 5.5698 4.1315 1.0149 2.5443 0.1622 0.2348 1.3541 0.0415 0.7848 0.0868</span> -<span class="r-out co"><span class="r-pr">#></span> 112: 92.5436 -5.6572 -2.2134 -4.3290 -0.9267 0.3025 5.2913 3.9249 1.0720 2.5118 0.1541 0.2231 1.3798 0.0385 0.9087 0.0799</span> -<span class="r-out co"><span class="r-pr">#></span> 113: 92.5970 -5.6263 -2.2030 -4.3044 -0.9123 0.2856 5.0268 3.7287 1.1371 2.4674 0.1764 0.2119 1.3007 0.0455 0.8651 0.0850</span> -<span class="r-out co"><span class="r-pr">#></span> 114: 92.9227 -5.6379 -2.2032 -4.2926 -0.9187 0.3282 4.7754 3.5422 1.1022 2.4105 0.1676 0.2013 1.3103 0.0439 0.9003 0.0815</span> -<span class="r-out co"><span class="r-pr">#></span> 115: 92.7678 -5.8033 -2.1888 -4.2988 -0.9406 0.3026 4.5367 3.3651 1.1127 2.5043 0.1592 0.1913 1.3643 0.0420 0.9649 0.0800</span> -<span class="r-out co"><span class="r-pr">#></span> 116: 92.0655 -5.8531 -2.2033 -4.2989 -0.9487 0.3013 4.3098 3.6792 1.1260 2.4981 0.1513 0.1817 1.2783 0.0445 0.9812 0.0818</span> -<span class="r-out co"><span class="r-pr">#></span> 117: 92.2258 -5.7861 -2.2095 -4.3393 -0.9399 0.2998 4.0943 3.4952 1.0697 2.7102 0.1437 0.1752 1.3037 0.0426 0.9067 0.0786</span> -<span class="r-out co"><span class="r-pr">#></span> 118: 92.3560 -5.8080 -2.2058 -4.3166 -0.9480 0.2743 4.6025 3.3205 1.0709 2.6198 0.1432 0.1747 1.2850 0.0481 0.9236 0.0769</span> -<span class="r-out co"><span class="r-pr">#></span> 119: 92.0489 -5.7726 -2.1972 -4.2740 -0.9087 0.2627 4.3723 3.1544 1.0892 2.4888 0.1620 0.1660 1.2659 0.0435 0.8389 0.0832</span> -<span class="r-out co"><span class="r-pr">#></span> 120: 91.9163 -5.8211 -2.2101 -4.2770 -0.9142 0.2674 4.1537 3.1700 1.0985 2.5003 0.1795 0.1577 1.2289 0.0454 0.9280 0.0826</span> -<span class="r-out co"><span class="r-pr">#></span> 121: 92.0274 -5.7601 -2.1916 -4.2686 -0.9055 0.2571 3.9460 3.1181 1.1026 2.3985 0.1908 0.1498 1.3015 0.0432 0.9363 0.0807</span> -<span class="r-out co"><span class="r-pr">#></span> 122: 92.2933 -5.7972 -2.2019 -4.2888 -0.8932 0.2679 3.7487 3.1755 1.0809 2.3976 0.1843 0.1636 1.2918 0.0433 0.8760 0.0803</span> -<span class="r-out co"><span class="r-pr">#></span> 123: 92.3361 -5.8903 -2.1745 -4.3386 -0.9157 0.2665 3.5613 3.8794 1.1308 2.5838 0.1751 0.1555 1.3219 0.0421 0.8987 0.0806</span> -<span class="r-out co"><span class="r-pr">#></span> 124: 92.5677 -6.0471 -2.1638 -4.2764 -0.9325 0.2645 3.3832 4.6152 1.1336 2.4546 0.1664 0.1526 1.2938 0.0375 0.9412 0.0798</span> -<span class="r-out co"><span class="r-pr">#></span> 125: 92.7852 -5.9841 -2.1661 -4.2825 -0.9373 0.2866 3.2141 4.3844 1.0770 2.3788 0.1581 0.1727 1.3137 0.0417 0.9228 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 126: 92.7867 -5.9126 -2.1636 -4.2413 -0.9141 0.2756 3.0534 4.1652 1.0857 2.2921 0.1502 0.1994 1.2428 0.0450 0.8206 0.0795</span> -<span class="r-out co"><span class="r-pr">#></span> 127: 92.8733 -5.9110 -2.1546 -4.2269 -0.9258 0.2531 2.9007 3.9569 1.0914 2.3822 0.1426 0.2029 1.3043 0.0369 0.8206 0.0795</span> -<span class="r-out co"><span class="r-pr">#></span> 128: 93.0457 -5.9202 -2.1505 -4.2076 -0.9466 0.2463 3.3353 3.7591 1.0647 2.3012 0.1355 0.2180 1.3420 0.0385 0.8503 0.0803</span> -<span class="r-out co"><span class="r-pr">#></span> 129: 92.9207 -5.9882 -2.1704 -4.2204 -0.9319 0.2464 4.3160 4.4368 1.1187 2.3415 0.1386 0.2316 1.2546 0.0435 0.8777 0.0830</span> -<span class="r-out co"><span class="r-pr">#></span> 130: 92.2660 -6.2043 -2.1712 -4.2251 -0.9276 0.2186 4.4370 5.1440 1.0817 2.3426 0.1338 0.2200 1.2733 0.0476 0.9132 0.0753</span> -<span class="r-out co"><span class="r-pr">#></span> 131: 92.1286 -6.4163 -2.1634 -4.2642 -0.9223 0.2300 4.2151 6.2253 1.0614 2.5012 0.1333 0.2090 1.2690 0.0430 0.8201 0.0814</span> -<span class="r-out co"><span class="r-pr">#></span> 132: 92.0287 -6.4297 -2.1522 -4.2717 -0.9259 0.2250 4.0044 6.1979 1.0791 2.5146 0.1314 0.1985 1.2736 0.0449 0.8671 0.0784</span> -<span class="r-out co"><span class="r-pr">#></span> 133: 91.6843 -6.1415 -2.1685 -4.2553 -0.9349 0.2209 3.8041 5.8880 1.1445 2.4277 0.1248 0.2026 1.3381 0.0426 0.9129 0.0858</span> -<span class="r-out co"><span class="r-pr">#></span> 134: 91.6928 -6.1408 -2.1467 -4.2709 -0.9270 0.2648 3.6139 5.5936 1.0873 2.5602 0.1305 0.1925 1.3202 0.0416 0.7626 0.0936</span> -<span class="r-out co"><span class="r-pr">#></span> 135: 91.7984 -6.0371 -2.1673 -4.2572 -0.9497 0.2480 3.4332 5.3139 1.0649 2.4322 0.1389 0.1829 1.2592 0.0544 0.9459 0.0831</span> -<span class="r-out co"><span class="r-pr">#></span> 136: 91.9754 -6.1770 -2.1769 -4.2311 -0.9401 0.2435 3.2616 5.0482 1.0717 2.3106 0.1691 0.1737 1.3170 0.0436 1.0497 0.0816</span> -<span class="r-out co"><span class="r-pr">#></span> 137: 92.1546 -6.1216 -2.1731 -4.2278 -0.9401 0.2492 3.0985 4.9378 1.0200 2.1950 0.1606 0.1988 1.4019 0.0421 1.0200 0.0766</span> -<span class="r-out co"><span class="r-pr">#></span> 138: 92.2370 -5.9463 -2.1794 -4.1949 -0.9321 0.2460 2.9436 4.6909 1.0203 2.1200 0.1535 0.1947 1.3378 0.0425 0.9448 0.0804</span> -<span class="r-out co"><span class="r-pr">#></span> 139: 92.2025 -5.8849 -2.1820 -4.1868 -0.9200 0.2294 2.9458 4.4564 0.9875 2.1260 0.1759 0.2080 1.3244 0.0428 1.0110 0.0778</span> -<span class="r-out co"><span class="r-pr">#></span> 140: 91.8182 -5.7494 -2.1569 -4.1998 -0.9095 0.2318 2.7985 4.2336 1.0015 2.1507 0.1830 0.2113 1.3502 0.0432 0.7716 0.0922</span> -<span class="r-out co"><span class="r-pr">#></span> 141: 91.8292 -5.9568 -2.1640 -4.2109 -0.9122 0.2130 4.4608 4.0219 1.0180 2.1032 0.1739 0.2057 1.3594 0.0419 0.8088 0.0883</span> -<span class="r-out co"><span class="r-pr">#></span> 142: 91.9995 -6.0927 -2.1471 -4.2313 -0.9091 0.1875 4.5415 4.7705 1.0571 2.1286 0.1810 0.1954 1.4145 0.0406 0.8943 0.0847</span> -<span class="r-out co"><span class="r-pr">#></span> 143: 91.9160 -5.9892 -2.1546 -4.2043 -0.9355 0.1819 4.3145 4.5320 1.1337 2.1453 0.1888 0.2208 1.3449 0.0394 1.0910 0.0797</span> -<span class="r-out co"><span class="r-pr">#></span> 144: 92.0136 -5.9765 -2.1643 -4.2346 -0.9448 0.2455 4.3041 4.3054 1.1130 2.1300 0.1817 0.3253 1.3828 0.0340 1.0535 0.0873</span> -<span class="r-out co"><span class="r-pr">#></span> 145: 92.3893 -6.2224 -2.1211 -4.2316 -0.9405 0.2285 5.2279 4.9099 1.0573 2.1037 0.1727 0.3091 1.3797 0.0340 1.0160 0.0832</span> -<span class="r-out co"><span class="r-pr">#></span> 146: 92.6097 -6.2204 -2.1406 -4.2210 -0.9217 0.1762 4.9665 5.4466 1.0724 2.1658 0.1640 0.2936 1.4421 0.0408 1.2412 0.0674</span> -<span class="r-out co"><span class="r-pr">#></span> 147: 92.8499 -6.0091 -2.1165 -4.2234 -0.9682 0.1783 4.7182 5.1743 1.0188 2.1714 0.1722 0.2789 1.4545 0.0397 1.4472 0.0556</span> -<span class="r-out co"><span class="r-pr">#></span> 148: 92.6602 -5.8003 -2.1059 -4.2132 -0.9282 0.2102 4.4823 4.9156 1.0106 2.1075 0.1880 0.2684 1.4013 0.0413 1.0748 0.0758</span> -<span class="r-out co"><span class="r-pr">#></span> 149: 92.7388 -5.8727 -2.1569 -4.2185 -0.9266 0.1868 4.2581 4.6698 1.1447 2.0851 0.1786 0.2550 1.3137 0.0413 0.9963 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 150: 92.7348 -5.7926 -2.1184 -4.2257 -0.9324 0.1966 4.0452 4.4363 1.1760 2.1508 0.1697 0.2704 1.3792 0.0363 0.8204 0.0889</span> -<span class="r-out co"><span class="r-pr">#></span> 151: 92.7968 -5.7301 -2.1179 -4.1959 -0.9275 0.1927 3.8430 4.2145 1.1707 2.1702 0.1842 0.2569 1.3789 0.0387 0.7890 0.0873</span> -<span class="r-out co"><span class="r-pr">#></span> 152: 92.9011 -5.7417 -2.1622 -4.2086 -0.9215 0.1784 2.0089 3.0670 1.1984 2.2253 0.1814 0.2507 1.3431 0.0395 0.9622 0.0780</span> -<span class="r-out co"><span class="r-pr">#></span> 153: 92.8020 -5.7707 -2.1494 -4.2128 -0.9228 0.1818 2.2261 2.9648 1.1192 2.3058 0.1749 0.2548 1.3671 0.0369 0.9507 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 154: 92.5217 -5.8043 -2.1447 -4.2074 -0.9303 0.1766 2.7638 3.1314 1.1141 2.2814 0.1811 0.2389 1.3250 0.0408 1.0538 0.0689</span> -<span class="r-out co"><span class="r-pr">#></span> 155: 92.8765 -5.5586 -2.1275 -4.1639 -0.9320 0.1434 2.4217 2.4658 1.1231 2.1314 0.1746 0.2426 1.3785 0.0407 0.9682 0.0796</span> -<span class="r-out co"><span class="r-pr">#></span> 156: 93.0074 -5.6819 -2.1343 -4.1819 -0.9382 0.1587 1.4756 2.7496 1.1200 2.1700 0.1849 0.2320 1.3643 0.0395 1.0875 0.0653</span> -<span class="r-out co"><span class="r-pr">#></span> 157: 92.7950 -5.6827 -2.1178 -4.1808 -0.9553 0.1585 1.1607 2.5156 1.1129 2.2109 0.1724 0.2366 1.4045 0.0374 1.1322 0.0676</span> -<span class="r-out co"><span class="r-pr">#></span> 158: 92.7684 -5.7106 -2.0933 -4.2149 -0.9717 0.1602 1.4884 2.6532 1.1269 2.1388 0.1838 0.2666 1.4009 0.0348 0.8728 0.0832</span> -<span class="r-out co"><span class="r-pr">#></span> 159: 93.0980 -5.8911 -2.1297 -4.2160 -0.9660 0.1407 1.6034 3.3765 1.1182 2.1661 0.1705 0.2804 1.3557 0.0430 1.0076 0.0776</span> -<span class="r-out co"><span class="r-pr">#></span> 160: 93.1849 -5.9433 -2.1177 -4.1735 -0.9436 0.1324 1.8692 4.0887 1.1252 2.0213 0.1642 0.2922 1.3251 0.0386 0.8586 0.0820</span> -<span class="r-out co"><span class="r-pr">#></span> 161: 93.4771 -5.7768 -2.0899 -4.1697 -0.9670 0.1043 2.0938 2.9110 1.1069 1.9538 0.1820 0.3046 1.3270 0.0413 0.8220 0.0855</span> -<span class="r-out co"><span class="r-pr">#></span> 162: 93.4961 -5.6516 -2.0965 -4.1633 -0.9708 0.1263 2.2053 2.3022 1.1179 1.9555 0.1758 0.2891 1.3158 0.0417 0.9943 0.0768</span> -<span class="r-out co"><span class="r-pr">#></span> 163: 93.1627 -5.5944 -2.1527 -4.1633 -0.9488 0.1452 2.9600 2.3291 1.1027 1.9555 0.1766 0.3000 1.3626 0.0376 0.9790 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 164: 92.7951 -5.6646 -2.1539 -4.1699 -0.9447 0.1863 2.9195 2.7599 1.0794 1.9511 0.1651 0.2918 1.4091 0.0357 1.1005 0.0709</span> -<span class="r-out co"><span class="r-pr">#></span> 165: 92.6045 -5.5927 -2.1842 -4.1770 -0.9436 0.1939 2.2014 2.3213 1.0622 1.9775 0.1671 0.2899 1.3945 0.0372 1.0533 0.0694</span> -<span class="r-out co"><span class="r-pr">#></span> 166: 92.6660 -5.5922 -2.1438 -4.1611 -0.9441 0.1767 1.8951 2.3445 1.1025 2.0399 0.1802 0.2802 1.4229 0.0354 1.1552 0.0682</span> -<span class="r-out co"><span class="r-pr">#></span> 167: 92.4353 -5.5118 -2.1415 -4.1730 -0.9124 0.1827 1.5029 1.8145 1.0701 2.0090 0.1727 0.2642 1.4525 0.0362 1.0577 0.0754</span> -<span class="r-out co"><span class="r-pr">#></span> 168: 92.3761 -5.5522 -2.1625 -4.1911 -0.9114 0.1782 1.2703 2.0808 1.0814 2.0588 0.1810 0.2658 1.3973 0.0364 0.9874 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 169: 92.5240 -5.6102 -2.1396 -4.1793 -0.8972 0.1722 1.3115 2.2750 1.0759 2.0910 0.2147 0.2549 1.3553 0.0392 0.9770 0.0759</span> -<span class="r-out co"><span class="r-pr">#></span> 170: 92.3827 -5.5942 -2.1231 -4.1847 -0.9338 0.1525 1.5707 2.3778 1.0542 2.0824 0.2042 0.2519 1.4424 0.0363 1.1270 0.0687</span> -<span class="r-out co"><span class="r-pr">#></span> 171: 92.1706 -5.6171 -2.1619 -4.1926 -0.9056 0.1390 1.0935 2.2869 1.1239 2.1697 0.1946 0.2624 1.2980 0.0411 0.9988 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 172: 92.1491 -5.5704 -2.1447 -4.1913 -0.9285 0.1649 1.0292 2.2160 1.1231 2.1905 0.1860 0.2518 1.3154 0.0375 1.0152 0.0772</span> -<span class="r-out co"><span class="r-pr">#></span> 173: 91.9987 -5.5411 -2.1434 -4.1803 -0.9056 0.1585 0.6511 1.9989 1.0892 2.2283 0.1899 0.2413 1.3814 0.0380 1.1733 0.0693</span> -<span class="r-out co"><span class="r-pr">#></span> 174: 92.0377 -5.5419 -2.1081 -4.1928 -0.9057 0.1418 0.9013 2.0933 1.1813 2.2773 0.1756 0.2559 1.4419 0.0343 0.9942 0.0801</span> -<span class="r-out co"><span class="r-pr">#></span> 175: 92.0266 -5.5125 -2.1014 -4.1775 -0.9119 0.1371 0.7194 2.0624 1.1848 2.2328 0.1754 0.2504 1.3987 0.0353 1.0838 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 176: 92.0365 -5.5658 -2.0914 -4.1646 -0.8956 0.1096 0.7557 2.0588 1.1642 2.1610 0.1617 0.2722 1.3658 0.0347 0.9405 0.0757</span> -<span class="r-out co"><span class="r-pr">#></span> 177: 91.8661 -5.6799 -2.0950 -4.1695 -0.9010 0.1193 0.8835 2.8899 1.1394 2.1886 0.1809 0.2777 1.3841 0.0351 0.9178 0.0794</span> -<span class="r-out co"><span class="r-pr">#></span> 178: 91.9392 -5.7853 -2.1139 -4.1711 -0.9190 0.1222 0.6673 3.0461 1.1712 2.1948 0.1576 0.2237 1.3623 0.0383 0.9060 0.0795</span> -<span class="r-out co"><span class="r-pr">#></span> 179: 92.0116 -5.7560 -2.1418 -4.1711 -0.9153 0.1034 0.4356 2.9139 1.1653 2.1948 0.1497 0.2364 1.3387 0.0392 0.9327 0.0793</span> -<span class="r-out co"><span class="r-pr">#></span> 180: 92.1013 -5.7920 -2.1368 -4.1654 -0.9059 0.0912 0.3859 3.2592 1.1357 2.1744 0.1570 0.2337 1.3622 0.0408 1.0299 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 181: 92.1032 -5.8125 -2.1260 -4.1791 -0.9404 0.1731 0.4091 3.0817 1.1113 2.2356 0.1572 0.2742 1.4509 0.0340 0.9180 0.0865</span> -<span class="r-out co"><span class="r-pr">#></span> 182: 92.1315 -5.7991 -2.1327 -4.1737 -0.9319 0.1519 0.3145 3.0292 1.1520 2.1360 0.1661 0.2482 1.4105 0.0361 1.1338 0.0748</span> -<span class="r-out co"><span class="r-pr">#></span> 183: 92.1350 -6.0470 -2.1264 -4.1707 -0.9525 0.1787 0.2045 3.8296 1.1229 2.1369 0.1735 0.2453 1.3132 0.0350 1.0507 0.0759</span> -<span class="r-out co"><span class="r-pr">#></span> 184: 92.0539 -5.9856 -2.1289 -4.1968 -0.9281 0.1789 0.1166 3.9425 1.0558 2.2320 0.1658 0.2253 1.3390 0.0355 1.1271 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 185: 92.0755 -6.0524 -2.1385 -4.2076 -0.9313 0.1794 0.1193 4.2430 1.0465 2.3571 0.1566 0.2152 1.3777 0.0368 1.2013 0.0631</span> -<span class="r-out co"><span class="r-pr">#></span> 186: 92.1639 -6.0663 -2.1399 -4.1869 -0.9311 0.1817 0.1392 4.4053 1.0495 2.4857 0.1532 0.2331 1.3751 0.0365 1.0497 0.0697</span> -<span class="r-out co"><span class="r-pr">#></span> 187: 92.1759 -6.3052 -2.1469 -4.2221 -0.9428 0.1970 0.1356 5.5622 0.9953 2.3367 0.1451 0.2359 1.3754 0.0367 1.0969 0.0656</span> -<span class="r-out co"><span class="r-pr">#></span> 188: 92.1744 -6.0494 -2.1406 -4.2445 -0.9595 0.2089 0.1364 4.3818 0.9882 2.4074 0.1480 0.2364 1.3709 0.0396 1.1259 0.0642</span> -<span class="r-out co"><span class="r-pr">#></span> 189: 92.1989 -6.1255 -2.1138 -4.2037 -0.9368 0.1796 0.1444 4.6756 0.9840 2.3786 0.1502 0.2303 1.3979 0.0393 1.2011 0.0630</span> -<span class="r-out co"><span class="r-pr">#></span> 190: 92.0944 -6.1343 -2.1536 -4.2106 -0.9267 0.2105 0.1288 4.4977 1.0475 2.3593 0.1443 0.2396 1.3247 0.0384 1.1304 0.0711</span> -<span class="r-out co"><span class="r-pr">#></span> 191: 92.1238 -6.0639 -2.1462 -4.2883 -0.9311 0.2155 0.1246 4.1066 1.0428 2.6836 0.1442 0.2344 1.4041 0.0344 1.1631 0.0684</span> -<span class="r-out co"><span class="r-pr">#></span> 192: 92.1328 -6.0743 -2.1232 -4.3119 -0.9586 0.2319 0.1192 4.1348 1.0020 2.7067 0.1466 0.2515 1.4039 0.0355 1.0021 0.0772</span> -<span class="r-out co"><span class="r-pr">#></span> 193: 92.0881 -5.8697 -2.1298 -4.2691 -0.9309 0.2295 0.1050 3.4476 0.9879 2.5496 0.1344 0.2348 1.4677 0.0351 1.0332 0.0705</span> -<span class="r-out co"><span class="r-pr">#></span> 194: 92.1086 -5.7557 -2.1176 -4.3249 -0.9029 0.2183 0.0702 2.7793 1.0043 2.8853 0.1460 0.2213 1.4733 0.0325 1.0929 0.0681</span> -<span class="r-out co"><span class="r-pr">#></span> 195: 92.1265 -5.8976 -2.1506 -4.2932 -0.9267 0.2511 0.0593 3.4959 0.9881 2.6806 0.1278 0.2505 1.6138 0.0350 1.1327 0.0703</span> -<span class="r-out co"><span class="r-pr">#></span> 196: 92.1316 -5.7018 -2.1627 -4.2889 -0.9278 0.2392 0.0717 2.9210 1.0160 2.7067 0.1470 0.2350 1.5063 0.0418 1.0525 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 197: 92.1756 -5.7899 -2.1604 -4.2819 -0.9248 0.2765 0.0754 2.9991 1.0167 2.6170 0.1465 0.2314 1.4982 0.0387 1.0504 0.0774</span> -<span class="r-out co"><span class="r-pr">#></span> 198: 92.2153 -5.8248 -2.1571 -4.2245 -0.9350 0.2195 0.0651 3.0128 0.9196 2.3123 0.1451 0.2363 1.3965 0.0453 1.1561 0.0650</span> -<span class="r-out co"><span class="r-pr">#></span> 199: 92.1935 -5.8187 -2.1505 -4.2123 -0.9452 0.2406 0.0535 3.0017 0.9553 2.2771 0.1338 0.2415 1.4485 0.0407 1.0647 0.0699</span> -<span class="r-out co"><span class="r-pr">#></span> 200: 92.2308 -5.6732 -2.1578 -4.2182 -0.9324 0.2330 0.0618 2.4070 1.0687 2.2978 0.1513 0.2199 1.4101 0.0385 1.0283 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 201: 92.2305 -5.6796 -2.1604 -4.2064 -0.9320 0.2262 0.0530 2.4360 1.0551 2.2994 0.1529 0.2219 1.3653 0.0407 1.0115 0.0757</span> -<span class="r-out co"><span class="r-pr">#></span> 202: 92.2259 -5.7201 -2.1550 -4.2058 -0.9263 0.2208 0.0461 2.6422 1.0351 2.2888 0.1520 0.2100 1.3739 0.0418 1.0474 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 203: 92.2212 -5.7539 -2.1457 -4.2037 -0.9303 0.2163 0.0422 2.8480 1.0403 2.2723 0.1465 0.2070 1.3973 0.0404 1.0518 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 204: 92.2164 -5.8068 -2.1371 -4.2093 -0.9300 0.2163 0.0383 3.1313 1.0426 2.2984 0.1423 0.2091 1.4025 0.0391 1.0284 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 205: 92.2120 -5.8371 -2.1369 -4.2142 -0.9308 0.2156 0.0347 3.2786 1.0392 2.3249 0.1390 0.2048 1.4115 0.0385 1.0161 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 206: 92.2071 -5.8681 -2.1391 -4.2176 -0.9287 0.2158 0.0336 3.4917 1.0442 2.3461 0.1388 0.2041 1.4017 0.0394 0.9977 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 207: 92.2078 -5.8966 -2.1424 -4.2230 -0.9286 0.2181 0.0337 3.6741 1.0456 2.3743 0.1369 0.2009 1.3988 0.0397 0.9792 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 208: 92.2077 -5.8972 -2.1459 -4.2249 -0.9300 0.2208 0.0340 3.6775 1.0460 2.3889 0.1362 0.1985 1.3969 0.0394 0.9729 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 209: 92.2091 -5.8831 -2.1488 -4.2271 -0.9326 0.2227 0.0337 3.6019 1.0465 2.4005 0.1380 0.1967 1.3949 0.0395 0.9745 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 210: 92.2115 -5.8806 -2.1490 -4.2282 -0.9349 0.2238 0.0324 3.5652 1.0516 2.4211 0.1386 0.1979 1.3941 0.0391 0.9820 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 211: 92.2151 -5.8791 -2.1516 -4.2291 -0.9363 0.2258 0.0318 3.5315 1.0458 2.4465 0.1390 0.1989 1.3918 0.0394 0.9901 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 212: 92.2189 -5.8789 -2.1532 -4.2297 -0.9380 0.2269 0.0312 3.4989 1.0434 2.4718 0.1409 0.1993 1.3884 0.0394 1.0007 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 213: 92.2226 -5.8714 -2.1556 -4.2287 -0.9395 0.2255 0.0313 3.4460 1.0440 2.4800 0.1413 0.1993 1.3859 0.0397 1.0157 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 214: 92.2233 -5.8706 -2.1553 -4.2279 -0.9394 0.2237 0.0309 3.4283 1.0431 2.4809 0.1414 0.2003 1.3849 0.0399 1.0186 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 215: 92.2242 -5.8750 -2.1536 -4.2285 -0.9390 0.2212 0.0312 3.4442 1.0455 2.4800 0.1417 0.2015 1.3830 0.0401 1.0126 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 216: 92.2252 -5.8788 -2.1521 -4.2277 -0.9393 0.2192 0.0316 3.4718 1.0459 2.4791 0.1410 0.2028 1.3817 0.0402 1.0046 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 217: 92.2255 -5.8869 -2.1516 -4.2268 -0.9400 0.2177 0.0322 3.5295 1.0456 2.4751 0.1407 0.2042 1.3814 0.0401 1.0011 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 218: 92.2230 -5.8819 -2.1511 -4.2259 -0.9400 0.2164 0.0327 3.5004 1.0473 2.4693 0.1399 0.2051 1.3784 0.0401 0.9962 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 219: 92.2206 -5.8761 -2.1499 -4.2269 -0.9393 0.2156 0.0325 3.4736 1.0494 2.4667 0.1399 0.2066 1.3794 0.0399 0.9925 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 220: 92.2185 -5.8775 -2.1494 -4.2267 -0.9380 0.2150 0.0331 3.4894 1.0511 2.4596 0.1396 0.2090 1.3788 0.0398 0.9881 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 221: 92.2180 -5.8774 -2.1499 -4.2271 -0.9369 0.2142 0.0328 3.4873 1.0518 2.4559 0.1399 0.2109 1.3776 0.0399 0.9842 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 222: 92.2191 -5.8833 -2.1503 -4.2280 -0.9359 0.2127 0.0328 3.5384 1.0518 2.4533 0.1400 0.2114 1.3778 0.0400 0.9825 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 223: 92.2199 -5.8831 -2.1486 -4.2288 -0.9343 0.2112 0.0326 3.5474 1.0539 2.4515 0.1396 0.2127 1.3795 0.0398 0.9806 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 224: 92.2206 -5.8870 -2.1467 -4.2283 -0.9331 0.2093 0.0324 3.5619 1.0550 2.4482 0.1395 0.2133 1.3805 0.0395 0.9792 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 225: 92.2218 -5.8929 -2.1459 -4.2289 -0.9328 0.2086 0.0322 3.6001 1.0548 2.4492 0.1388 0.2142 1.3804 0.0393 0.9809 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 226: 92.2228 -5.8909 -2.1440 -4.2293 -0.9322 0.2082 0.0320 3.6007 1.0566 2.4513 0.1383 0.2143 1.3826 0.0390 0.9815 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 227: 92.2234 -5.8838 -2.1444 -4.2304 -0.9319 0.2088 0.0319 3.5748 1.0551 2.4562 0.1381 0.2140 1.3814 0.0390 0.9836 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 228: 92.2243 -5.8835 -2.1444 -4.2314 -0.9326 0.2093 0.0317 3.5756 1.0526 2.4607 0.1377 0.2143 1.3824 0.0389 0.9901 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 229: 92.2251 -5.8916 -2.1442 -4.2307 -0.9330 0.2095 0.0318 3.6344 1.0501 2.4580 0.1371 0.2148 1.3850 0.0388 0.9930 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 230: 92.2250 -5.8951 -2.1442 -4.2303 -0.9334 0.2107 0.0318 3.6533 1.0475 2.4550 0.1369 0.2150 1.3872 0.0387 0.9953 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 231: 92.2247 -5.8964 -2.1444 -4.2300 -0.9345 0.2119 0.0322 3.6564 1.0446 2.4549 0.1368 0.2151 1.3899 0.0388 0.9991 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 232: 92.2230 -5.8982 -2.1451 -4.2306 -0.9352 0.2132 0.0326 3.6643 1.0422 2.4591 0.1365 0.2155 1.3934 0.0388 1.0052 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 233: 92.2223 -5.9022 -2.1455 -4.2327 -0.9354 0.2141 0.0329 3.6824 1.0396 2.4697 0.1362 0.2165 1.3970 0.0388 1.0107 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 234: 92.2200 -5.9075 -2.1457 -4.2324 -0.9348 0.2140 0.0335 3.7056 1.0364 2.4735 0.1366 0.2174 1.3977 0.0388 1.0163 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 235: 92.2171 -5.9094 -2.1457 -4.2338 -0.9342 0.2142 0.0342 3.7222 1.0339 2.4854 0.1372 0.2189 1.3999 0.0389 1.0228 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 236: 92.2161 -5.9195 -2.1464 -4.2368 -0.9340 0.2140 0.0346 3.7789 1.0329 2.4986 0.1376 0.2200 1.4007 0.0389 1.0281 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 237: 92.2163 -5.9214 -2.1469 -4.2390 -0.9330 0.2143 0.0347 3.7862 1.0329 2.5074 0.1378 0.2195 1.4030 0.0389 1.0320 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 238: 92.2165 -5.9203 -2.1473 -4.2399 -0.9326 0.2143 0.0347 3.7781 1.0336 2.5100 0.1381 0.2186 1.4031 0.0388 1.0347 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 239: 92.2173 -5.9212 -2.1471 -4.2403 -0.9325 0.2136 0.0344 3.7908 1.0350 2.5128 0.1384 0.2175 1.4021 0.0389 1.0352 0.0718</span> -<span class="r-out co"><span class="r-pr">#></span> 240: 92.2178 -5.9217 -2.1470 -4.2394 -0.9322 0.2133 0.0342 3.8082 1.0363 2.5118 0.1384 0.2169 1.4025 0.0387 1.0345 0.0719</span> -<span class="r-out co"><span class="r-pr">#></span> 241: 92.2177 -5.9200 -2.1470 -4.2383 -0.9318 0.2136 0.0340 3.8123 1.0381 2.5110 0.1385 0.2161 1.4028 0.0387 1.0336 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 242: 92.2170 -5.9109 -2.1478 -4.2371 -0.9308 0.2136 0.0340 3.7766 1.0387 2.5090 0.1385 0.2157 1.4027 0.0386 1.0322 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 243: 92.2165 -5.9029 -2.1484 -4.2371 -0.9300 0.2140 0.0340 3.7433 1.0389 2.5128 0.1386 0.2150 1.4032 0.0385 1.0342 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 244: 92.2161 -5.8998 -2.1489 -4.2374 -0.9294 0.2143 0.0340 3.7242 1.0392 2.5173 0.1386 0.2148 1.4030 0.0384 1.0343 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 245: 92.2153 -5.9048 -2.1494 -4.2370 -0.9291 0.2149 0.0339 3.7491 1.0399 2.5182 0.1386 0.2146 1.4019 0.0383 1.0317 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 246: 92.2147 -5.9093 -2.1498 -4.2371 -0.9289 0.2156 0.0339 3.7727 1.0409 2.5218 0.1384 0.2145 1.4016 0.0382 1.0309 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 247: 92.2143 -5.9124 -2.1503 -4.2368 -0.9286 0.2159 0.0338 3.7972 1.0408 2.5232 0.1383 0.2144 1.4012 0.0382 1.0297 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 248: 92.2137 -5.9122 -2.1500 -4.2367 -0.9286 0.2160 0.0336 3.8036 1.0409 2.5245 0.1382 0.2141 1.4022 0.0381 1.0272 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 249: 92.2133 -5.9101 -2.1501 -4.2364 -0.9288 0.2160 0.0334 3.7984 1.0406 2.5268 0.1383 0.2136 1.4031 0.0381 1.0273 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 250: 92.2139 -5.9115 -2.1502 -4.2368 -0.9289 0.2167 0.0335 3.8015 1.0412 2.5326 0.1380 0.2132 1.4035 0.0381 1.0261 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 251: 92.2132 -5.9123 -2.1502 -4.2373 -0.9297 0.2170 0.0338 3.8015 1.0421 2.5362 0.1376 0.2126 1.4053 0.0379 1.0274 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 252: 92.2128 -5.9106 -2.1502 -4.2366 -0.9299 0.2174 0.0338 3.7931 1.0427 2.5345 0.1371 0.2120 1.4062 0.0379 1.0262 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 253: 92.2118 -5.9098 -2.1492 -4.2364 -0.9297 0.2173 0.0340 3.8011 1.0420 2.5338 0.1369 0.2121 1.4074 0.0378 1.0232 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 254: 92.2107 -5.9104 -2.1479 -4.2362 -0.9296 0.2171 0.0341 3.8085 1.0398 2.5330 0.1366 0.2123 1.4093 0.0377 1.0230 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 255: 92.2103 -5.9133 -2.1466 -4.2359 -0.9299 0.2166 0.0341 3.8219 1.0381 2.5346 0.1363 0.2122 1.4105 0.0377 1.0230 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 256: 92.2094 -5.9171 -2.1453 -4.2356 -0.9299 0.2161 0.0341 3.8498 1.0366 2.5366 0.1362 0.2123 1.4114 0.0375 1.0239 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 257: 92.2091 -5.9169 -2.1441 -4.2353 -0.9302 0.2153 0.0341 3.8529 1.0347 2.5385 0.1360 0.2118 1.4126 0.0375 1.0265 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 258: 92.2089 -5.9191 -2.1431 -4.2349 -0.9301 0.2145 0.0340 3.8608 1.0331 2.5392 0.1359 0.2119 1.4126 0.0375 1.0282 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 259: 92.2093 -5.9249 -2.1426 -4.2337 -0.9301 0.2145 0.0341 3.8853 1.0321 2.5385 0.1361 0.2120 1.4114 0.0374 1.0280 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 260: 92.2095 -5.9297 -2.1415 -4.2328 -0.9303 0.2146 0.0339 3.9108 1.0302 2.5367 0.1358 0.2125 1.4112 0.0373 1.0265 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 261: 92.2096 -5.9341 -2.1407 -4.2321 -0.9307 0.2147 0.0338 3.9343 1.0278 2.5343 0.1356 0.2131 1.4121 0.0373 1.0272 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 262: 92.2094 -5.9342 -2.1398 -4.2312 -0.9310 0.2149 0.0336 3.9314 1.0254 2.5313 0.1356 0.2139 1.4115 0.0372 1.0249 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 263: 92.2088 -5.9376 -2.1388 -4.2304 -0.9313 0.2153 0.0334 3.9452 1.0232 2.5289 0.1357 0.2143 1.4109 0.0371 1.0228 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 264: 92.2077 -5.9410 -2.1379 -4.2301 -0.9317 0.2153 0.0333 3.9571 1.0204 2.5265 0.1356 0.2147 1.4105 0.0371 1.0224 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 265: 92.2069 -5.9454 -2.1374 -4.2296 -0.9322 0.2154 0.0332 3.9800 1.0182 2.5230 0.1356 0.2147 1.4115 0.0371 1.0232 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 266: 92.2067 -5.9463 -2.1370 -4.2291 -0.9324 0.2155 0.0330 3.9809 1.0165 2.5217 0.1354 0.2148 1.4121 0.0371 1.0220 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 267: 92.2064 -5.9492 -2.1368 -4.2282 -0.9329 0.2154 0.0328 3.9874 1.0150 2.5199 0.1357 0.2150 1.4124 0.0370 1.0233 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 268: 92.2065 -5.9468 -2.1360 -4.2276 -0.9333 0.2155 0.0328 3.9722 1.0133 2.5171 0.1362 0.2155 1.4133 0.0369 1.0243 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 269: 92.2066 -5.9438 -2.1352 -4.2267 -0.9335 0.2151 0.0328 3.9526 1.0122 2.5142 0.1367 0.2154 1.4140 0.0369 1.0244 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 270: 92.2067 -5.9388 -2.1351 -4.2259 -0.9339 0.2151 0.0326 3.9283 1.0112 2.5114 0.1370 0.2157 1.4137 0.0368 1.0240 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 271: 92.2069 -5.9350 -2.1344 -4.2252 -0.9342 0.2152 0.0324 3.9072 1.0107 2.5094 0.1370 0.2158 1.4136 0.0367 1.0222 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 272: 92.2069 -5.9317 -2.1341 -4.2246 -0.9348 0.2153 0.0321 3.8870 1.0104 2.5082 0.1372 0.2157 1.4139 0.0366 1.0219 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 273: 92.2068 -5.9289 -2.1340 -4.2240 -0.9348 0.2152 0.0320 3.8711 1.0101 2.5075 0.1373 0.2159 1.4146 0.0366 1.0232 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 274: 92.2067 -5.9271 -2.1337 -4.2239 -0.9350 0.2153 0.0318 3.8569 1.0101 2.5085 0.1377 0.2157 1.4144 0.0366 1.0239 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 275: 92.2063 -5.9264 -2.1339 -4.2235 -0.9353 0.2156 0.0317 3.8476 1.0097 2.5078 0.1382 0.2157 1.4143 0.0365 1.0256 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 276: 92.2059 -5.9271 -2.1339 -4.2231 -0.9354 0.2160 0.0316 3.8417 1.0097 2.5074 0.1387 0.2156 1.4132 0.0365 1.0260 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 277: 92.2059 -5.9283 -2.1342 -4.2225 -0.9356 0.2163 0.0316 3.8412 1.0094 2.5073 0.1393 0.2155 1.4122 0.0364 1.0283 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 278: 92.2062 -5.9278 -2.1341 -4.2220 -0.9361 0.2166 0.0318 3.8331 1.0081 2.5069 0.1397 0.2154 1.4117 0.0364 1.0321 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 279: 92.2061 -5.9264 -2.1341 -4.2214 -0.9363 0.2168 0.0319 3.8188 1.0072 2.5051 0.1402 0.2155 1.4111 0.0364 1.0342 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 280: 92.2057 -5.9263 -2.1344 -4.2211 -0.9365 0.2167 0.0321 3.8114 1.0072 2.5061 0.1406 0.2148 1.4108 0.0365 1.0361 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 281: 92.2048 -5.9269 -2.1344 -4.2208 -0.9365 0.2166 0.0324 3.8082 1.0076 2.5077 0.1410 0.2142 1.4098 0.0365 1.0363 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 282: 92.2045 -5.9257 -2.1347 -4.2205 -0.9366 0.2165 0.0328 3.8040 1.0082 2.5092 0.1413 0.2138 1.4090 0.0365 1.0364 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 283: 92.2038 -5.9235 -2.1348 -4.2201 -0.9363 0.2163 0.0331 3.7955 1.0089 2.5108 0.1415 0.2134 1.4086 0.0365 1.0362 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 284: 92.2032 -5.9234 -2.1348 -4.2198 -0.9359 0.2162 0.0335 3.7945 1.0100 2.5118 0.1420 0.2129 1.4083 0.0365 1.0362 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 285: 92.2028 -5.9236 -2.1347 -4.2193 -0.9360 0.2161 0.0339 3.7930 1.0104 2.5124 0.1422 0.2125 1.4080 0.0365 1.0373 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 286: 92.2020 -5.9221 -2.1344 -4.2187 -0.9355 0.2156 0.0341 3.7872 1.0104 2.5134 0.1425 0.2121 1.4074 0.0364 1.0377 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 287: 92.2013 -5.9213 -2.1341 -4.2183 -0.9354 0.2154 0.0343 3.7888 1.0098 2.5151 0.1428 0.2119 1.4075 0.0364 1.0390 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 288: 92.2003 -5.9195 -2.1339 -4.2182 -0.9355 0.2152 0.0343 3.7831 1.0090 2.5180 0.1430 0.2116 1.4082 0.0364 1.0408 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 289: 92.1995 -5.9186 -2.1339 -4.2182 -0.9355 0.2154 0.0343 3.7805 1.0083 2.5217 0.1429 0.2115 1.4085 0.0364 1.0426 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 290: 92.1984 -5.9180 -2.1339 -4.2177 -0.9354 0.2153 0.0343 3.7767 1.0080 2.5219 0.1427 0.2113 1.4083 0.0365 1.0429 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 291: 92.1975 -5.9167 -2.1334 -4.2175 -0.9355 0.2151 0.0343 3.7701 1.0080 2.5230 0.1427 0.2108 1.4083 0.0364 1.0439 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 292: 92.1971 -5.9175 -2.1330 -4.2166 -0.9356 0.2144 0.0342 3.7722 1.0081 2.5227 0.1426 0.2107 1.4079 0.0364 1.0443 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 293: 92.1963 -5.9188 -2.1330 -4.2157 -0.9357 0.2141 0.0342 3.7768 1.0083 2.5242 0.1425 0.2103 1.4073 0.0364 1.0439 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 294: 92.1953 -5.9189 -2.1328 -4.2157 -0.9357 0.2136 0.0344 3.7727 1.0078 2.5294 0.1427 0.2095 1.4079 0.0364 1.0456 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 295: 92.1946 -5.9171 -2.1329 -4.2153 -0.9355 0.2135 0.0345 3.7623 1.0081 2.5331 0.1426 0.2090 1.4080 0.0364 1.0462 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 296: 92.1940 -5.9154 -2.1329 -4.2150 -0.9354 0.2130 0.0346 3.7523 1.0082 2.5354 0.1425 0.2084 1.4075 0.0365 1.0463 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 297: 92.1934 -5.9128 -2.1330 -4.2145 -0.9351 0.2127 0.0349 3.7395 1.0084 2.5373 0.1423 0.2079 1.4072 0.0365 1.0453 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 298: 92.1932 -5.9128 -2.1332 -4.2138 -0.9347 0.2120 0.0350 3.7372 1.0085 2.5368 0.1423 0.2075 1.4068 0.0365 1.0449 0.0720</span> -<span class="r-out co"><span class="r-pr">#></span> 299: 92.1927 -5.9120 -2.1333 -4.2131 -0.9344 0.2112 0.0352 3.7324 1.0088 2.5366 0.1422 0.2070 1.4059 0.0366 1.0441 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 300: 92.1921 -5.9097 -2.1335 -4.2122 -0.9343 0.2105 0.0353 3.7211 1.0096 2.5357 0.1425 0.2066 1.4050 0.0367 1.0443 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 301: 92.1915 -5.9081 -2.1337 -4.2116 -0.9343 0.2098 0.0355 3.7110 1.0104 2.5355 0.1427 0.2061 1.4041 0.0368 1.0448 0.0721</span> -<span class="r-out co"><span class="r-pr">#></span> 302: 92.1912 -5.9067 -2.1340 -4.2108 -0.9342 0.2092 0.0355 3.7052 1.0114 2.5348 0.1428 0.2055 1.4036 0.0369 1.0442 0.0722</span> -<span class="r-out co"><span class="r-pr">#></span> 303: 92.1913 -5.9039 -2.1342 -4.2113 -0.9342 0.2087 0.0355 3.6925 1.0123 2.5408 0.1430 0.2049 1.4028 0.0369 1.0436 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 304: 92.1920 -5.9012 -2.1342 -4.2119 -0.9342 0.2081 0.0356 3.6781 1.0129 2.5476 0.1432 0.2044 1.4026 0.0369 1.0436 0.0723</span> -<span class="r-out co"><span class="r-pr">#></span> 305: 92.1923 -5.8984 -2.1343 -4.2123 -0.9341 0.2076 0.0354 3.6633 1.0134 2.5525 0.1434 0.2038 1.4022 0.0370 1.0434 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 306: 92.1926 -5.8977 -2.1343 -4.2121 -0.9343 0.2072 0.0354 3.6603 1.0144 2.5567 0.1436 0.2030 1.4022 0.0369 1.0431 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 307: 92.1931 -5.8970 -2.1346 -4.2124 -0.9344 0.2068 0.0353 3.6555 1.0154 2.5617 0.1438 0.2021 1.4017 0.0370 1.0431 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 308: 92.1935 -5.8963 -2.1347 -4.2127 -0.9343 0.2062 0.0351 3.6486 1.0166 2.5665 0.1439 0.2012 1.4017 0.0370 1.0431 0.0724</span> -<span class="r-out co"><span class="r-pr">#></span> 309: 92.1934 -5.8965 -2.1349 -4.2130 -0.9344 0.2058 0.0350 3.6454 1.0180 2.5711 0.1439 0.2003 1.4013 0.0370 1.0427 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 310: 92.1935 -5.8965 -2.1349 -4.2133 -0.9345 0.2055 0.0350 3.6401 1.0193 2.5761 0.1439 0.1993 1.4013 0.0371 1.0418 0.0725</span> -<span class="r-out co"><span class="r-pr">#></span> 311: 92.1931 -5.8976 -2.1349 -4.2139 -0.9346 0.2052 0.0349 3.6416 1.0207 2.5820 0.1437 0.1982 1.4015 0.0370 1.0411 0.0726</span> -<span class="r-out co"><span class="r-pr">#></span> 312: 92.1928 -5.8995 -2.1350 -4.2149 -0.9349 0.2053 0.0350 3.6472 1.0222 2.5902 0.1437 0.1972 1.4018 0.0370 1.0412 0.0727</span> -<span class="r-out co"><span class="r-pr">#></span> 313: 92.1922 -5.8999 -2.1350 -4.2159 -0.9352 0.2055 0.0350 3.6450 1.0236 2.5989 0.1436 0.1962 1.4017 0.0369 1.0407 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 314: 92.1913 -5.9021 -2.1353 -4.2171 -0.9353 0.2055 0.0350 3.6532 1.0244 2.6086 0.1437 0.1951 1.4019 0.0369 1.0409 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 315: 92.1905 -5.9033 -2.1358 -4.2178 -0.9354 0.2055 0.0351 3.6591 1.0252 2.6142 0.1438 0.1941 1.4018 0.0369 1.0420 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 316: 92.1895 -5.9043 -2.1358 -4.2186 -0.9352 0.2053 0.0352 3.6648 1.0266 2.6207 0.1441 0.1934 1.4016 0.0369 1.0420 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 317: 92.1888 -5.9041 -2.1359 -4.2200 -0.9352 0.2052 0.0352 3.6673 1.0278 2.6312 0.1444 0.1926 1.4014 0.0369 1.0416 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 318: 92.1879 -5.9039 -2.1360 -4.2212 -0.9352 0.2052 0.0354 3.6670 1.0292 2.6380 0.1446 0.1919 1.4010 0.0369 1.0403 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 319: 92.1871 -5.9046 -2.1361 -4.2222 -0.9353 0.2052 0.0354 3.6709 1.0306 2.6432 0.1448 0.1912 1.4008 0.0369 1.0394 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 320: 92.1863 -5.9023 -2.1365 -4.2229 -0.9355 0.2052 0.0355 3.6602 1.0318 2.6466 0.1448 0.1903 1.4011 0.0369 1.0398 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 321: 92.1855 -5.8996 -2.1368 -4.2236 -0.9354 0.2053 0.0355 3.6491 1.0329 2.6505 0.1448 0.1895 1.4017 0.0369 1.0402 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 322: 92.1850 -5.8979 -2.1370 -4.2243 -0.9353 0.2057 0.0356 3.6399 1.0341 2.6534 0.1447 0.1888 1.4020 0.0368 1.0394 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 323: 92.1844 -5.8984 -2.1371 -4.2251 -0.9352 0.2059 0.0356 3.6431 1.0346 2.6566 0.1447 0.1882 1.4026 0.0368 1.0389 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 324: 92.1838 -5.8967 -2.1372 -4.2257 -0.9353 0.2062 0.0356 3.6392 1.0351 2.6598 0.1445 0.1875 1.4031 0.0368 1.0382 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 325: 92.1835 -5.8936 -2.1374 -4.2264 -0.9351 0.2066 0.0355 3.6288 1.0352 2.6633 0.1444 0.1869 1.4043 0.0367 1.0391 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 326: 92.1837 -5.8936 -2.1376 -4.2276 -0.9350 0.2071 0.0354 3.6296 1.0354 2.6684 0.1444 0.1865 1.4043 0.0367 1.0380 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 327: 92.1837 -5.8943 -2.1378 -4.2289 -0.9347 0.2076 0.0354 3.6348 1.0357 2.6746 0.1444 0.1860 1.4043 0.0366 1.0380 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 328: 92.1838 -5.8953 -2.1380 -4.2297 -0.9345 0.2081 0.0354 3.6456 1.0360 2.6776 0.1444 0.1856 1.4043 0.0366 1.0379 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 329: 92.1836 -5.8974 -2.1383 -4.2305 -0.9342 0.2085 0.0356 3.6591 1.0361 2.6802 0.1444 0.1852 1.4043 0.0366 1.0385 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 330: 92.1832 -5.8994 -2.1387 -4.2305 -0.9342 0.2088 0.0358 3.6715 1.0364 2.6798 0.1443 0.1849 1.4037 0.0367 1.0378 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 331: 92.1826 -5.8983 -2.1391 -4.2302 -0.9342 0.2091 0.0357 3.6670 1.0368 2.6800 0.1442 0.1845 1.4038 0.0367 1.0379 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 332: 92.1824 -5.8959 -2.1396 -4.2301 -0.9341 0.2097 0.0357 3.6576 1.0375 2.6792 0.1442 0.1842 1.4034 0.0367 1.0372 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 333: 92.1826 -5.8937 -2.1401 -4.2304 -0.9340 0.2104 0.0356 3.6487 1.0383 2.6798 0.1442 0.1838 1.4029 0.0367 1.0360 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 334: 92.1825 -5.8911 -2.1407 -4.2311 -0.9339 0.2112 0.0355 3.6378 1.0390 2.6825 0.1444 0.1834 1.4025 0.0367 1.0349 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 335: 92.1830 -5.8887 -2.1411 -4.2317 -0.9336 0.2118 0.0355 3.6294 1.0396 2.6850 0.1444 0.1830 1.4022 0.0367 1.0338 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 336: 92.1834 -5.8872 -2.1413 -4.2324 -0.9334 0.2124 0.0356 3.6249 1.0402 2.6880 0.1444 0.1825 1.4024 0.0367 1.0339 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 337: 92.1835 -5.8869 -2.1416 -4.2334 -0.9332 0.2131 0.0356 3.6252 1.0411 2.6926 0.1443 0.1821 1.4029 0.0366 1.0330 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 338: 92.1839 -5.8882 -2.1418 -4.2346 -0.9333 0.2137 0.0357 3.6332 1.0421 2.6972 0.1441 0.1815 1.4036 0.0366 1.0324 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 339: 92.1845 -5.8869 -2.1420 -4.2358 -0.9332 0.2143 0.0357 3.6261 1.0428 2.7021 0.1439 0.1810 1.4043 0.0366 1.0322 0.0742</span> -<span class="r-out co"><span class="r-pr">#></span> 340: 92.1846 -5.8863 -2.1421 -4.2367 -0.9331 0.2147 0.0357 3.6242 1.0436 2.7060 0.1439 0.1804 1.4049 0.0365 1.0328 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 341: 92.1848 -5.8847 -2.1421 -4.2378 -0.9330 0.2150 0.0356 3.6177 1.0442 2.7099 0.1439 0.1798 1.4056 0.0366 1.0334 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 342: 92.1848 -5.8838 -2.1421 -4.2390 -0.9330 0.2154 0.0355 3.6114 1.0449 2.7151 0.1438 0.1792 1.4064 0.0365 1.0332 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 343: 92.1849 -5.8840 -2.1423 -4.2398 -0.9330 0.2157 0.0353 3.6109 1.0459 2.7191 0.1438 0.1785 1.4060 0.0366 1.0334 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 344: 92.1851 -5.8839 -2.1423 -4.2406 -0.9330 0.2159 0.0352 3.6092 1.0467 2.7229 0.1440 0.1779 1.4060 0.0365 1.0338 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 345: 92.1850 -5.8841 -2.1424 -4.2414 -0.9331 0.2162 0.0352 3.6070 1.0472 2.7263 0.1441 0.1774 1.4056 0.0365 1.0341 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 346: 92.1848 -5.8839 -2.1424 -4.2420 -0.9333 0.2164 0.0352 3.6048 1.0479 2.7292 0.1443 0.1769 1.4058 0.0365 1.0344 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 347: 92.1846 -5.8835 -2.1425 -4.2427 -0.9334 0.2166 0.0353 3.6017 1.0495 2.7330 0.1444 0.1763 1.4053 0.0365 1.0343 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 348: 92.1846 -5.8825 -2.1427 -4.2434 -0.9336 0.2168 0.0353 3.5968 1.0508 2.7362 0.1445 0.1757 1.4051 0.0365 1.0343 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 349: 92.1846 -5.8820 -2.1432 -4.2444 -0.9337 0.2172 0.0352 3.5937 1.0519 2.7412 0.1446 0.1752 1.4047 0.0365 1.0343 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 350: 92.1845 -5.8817 -2.1435 -4.2454 -0.9338 0.2179 0.0351 3.5899 1.0526 2.7460 0.1448 0.1747 1.4042 0.0365 1.0339 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 351: 92.1844 -5.8824 -2.1439 -4.2468 -0.9338 0.2184 0.0350 3.5917 1.0535 2.7531 0.1448 0.1740 1.4041 0.0365 1.0336 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 352: 92.1840 -5.8840 -2.1442 -4.2482 -0.9338 0.2189 0.0350 3.6013 1.0543 2.7603 0.1450 0.1734 1.4044 0.0364 1.0342 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 353: 92.1838 -5.8848 -2.1445 -4.2492 -0.9336 0.2194 0.0349 3.6030 1.0552 2.7652 0.1451 0.1730 1.4043 0.0364 1.0338 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 354: 92.1838 -5.8835 -2.1449 -4.2501 -0.9336 0.2197 0.0349 3.5961 1.0563 2.7697 0.1452 0.1723 1.4044 0.0364 1.0342 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 355: 92.1837 -5.8826 -2.1453 -4.2511 -0.9335 0.2199 0.0348 3.5910 1.0569 2.7757 0.1451 0.1718 1.4053 0.0364 1.0348 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 356: 92.1835 -5.8826 -2.1456 -4.2520 -0.9334 0.2198 0.0348 3.5922 1.0577 2.7815 0.1451 0.1712 1.4054 0.0364 1.0352 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 357: 92.1834 -5.8818 -2.1457 -4.2525 -0.9334 0.2198 0.0349 3.5894 1.0588 2.7852 0.1449 0.1706 1.4058 0.0364 1.0354 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 358: 92.1834 -5.8808 -2.1459 -4.2531 -0.9334 0.2197 0.0348 3.5861 1.0600 2.7891 0.1449 0.1701 1.4062 0.0364 1.0361 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 359: 92.1833 -5.8799 -2.1459 -4.2533 -0.9333 0.2197 0.0350 3.5822 1.0607 2.7903 0.1448 0.1696 1.4063 0.0364 1.0360 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 360: 92.1831 -5.8792 -2.1460 -4.2534 -0.9332 0.2196 0.0351 3.5787 1.0613 2.7914 0.1446 0.1691 1.4065 0.0364 1.0361 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 361: 92.1831 -5.8785 -2.1460 -4.2542 -0.9331 0.2196 0.0351 3.5771 1.0620 2.7969 0.1445 0.1688 1.4072 0.0364 1.0366 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 362: 92.1832 -5.8780 -2.1462 -4.2547 -0.9331 0.2195 0.0351 3.5750 1.0625 2.8017 0.1443 0.1683 1.4079 0.0363 1.0369 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 363: 92.1830 -5.8788 -2.1464 -4.2551 -0.9331 0.2192 0.0351 3.5785 1.0630 2.8057 0.1443 0.1677 1.4081 0.0363 1.0377 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 364: 92.1829 -5.8778 -2.1466 -4.2554 -0.9332 0.2193 0.0350 3.5747 1.0634 2.8092 0.1443 0.1672 1.4084 0.0363 1.0386 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 365: 92.1830 -5.8782 -2.1466 -4.2558 -0.9332 0.2192 0.0350 3.5771 1.0638 2.8135 0.1443 0.1667 1.4086 0.0363 1.0385 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 366: 92.1830 -5.8795 -2.1465 -4.2564 -0.9332 0.2190 0.0350 3.5838 1.0645 2.8190 0.1444 0.1661 1.4086 0.0363 1.0390 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 367: 92.1826 -5.8801 -2.1465 -4.2569 -0.9333 0.2191 0.0349 3.5867 1.0652 2.8232 0.1445 0.1657 1.4086 0.0362 1.0388 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 368: 92.1824 -5.8799 -2.1465 -4.2571 -0.9333 0.2193 0.0348 3.5859 1.0654 2.8252 0.1445 0.1653 1.4088 0.0362 1.0385 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 369: 92.1822 -5.8803 -2.1467 -4.2572 -0.9333 0.2193 0.0348 3.5846 1.0653 2.8261 0.1444 0.1648 1.4086 0.0362 1.0393 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 370: 92.1820 -5.8802 -2.1469 -4.2575 -0.9333 0.2195 0.0348 3.5822 1.0653 2.8273 0.1444 0.1645 1.4088 0.0362 1.0396 0.0744</span> -<span class="r-out co"><span class="r-pr">#></span> 371: 92.1818 -5.8806 -2.1470 -4.2575 -0.9333 0.2198 0.0348 3.5819 1.0649 2.8277 0.1443 0.1642 1.4091 0.0362 1.0403 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 372: 92.1818 -5.8804 -2.1473 -4.2580 -0.9332 0.2202 0.0348 3.5795 1.0645 2.8300 0.1441 0.1640 1.4096 0.0362 1.0418 0.0743</span> -<span class="r-out co"><span class="r-pr">#></span> 373: 92.1816 -5.8812 -2.1475 -4.2580 -0.9332 0.2203 0.0348 3.5816 1.0644 2.8298 0.1441 0.1639 1.4100 0.0362 1.0439 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 374: 92.1815 -5.8817 -2.1477 -4.2578 -0.9333 0.2203 0.0349 3.5819 1.0641 2.8282 0.1440 0.1641 1.4099 0.0362 1.0443 0.0741</span> -<span class="r-out co"><span class="r-pr">#></span> 375: 92.1817 -5.8828 -2.1479 -4.2574 -0.9335 0.2204 0.0351 3.5853 1.0636 2.8267 0.1440 0.1642 1.4100 0.0362 1.0457 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 376: 92.1819 -5.8826 -2.1479 -4.2573 -0.9338 0.2206 0.0353 3.5843 1.0634 2.8246 0.1440 0.1643 1.4100 0.0362 1.0464 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 377: 92.1819 -5.8826 -2.1480 -4.2572 -0.9339 0.2206 0.0354 3.5819 1.0633 2.8225 0.1440 0.1644 1.4097 0.0363 1.0470 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 378: 92.1819 -5.8821 -2.1481 -4.2571 -0.9340 0.2205 0.0355 3.5777 1.0633 2.8206 0.1440 0.1644 1.4093 0.0363 1.0468 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 379: 92.1819 -5.8823 -2.1481 -4.2573 -0.9340 0.2205 0.0356 3.5746 1.0633 2.8201 0.1439 0.1645 1.4092 0.0363 1.0468 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 380: 92.1820 -5.8809 -2.1481 -4.2570 -0.9340 0.2205 0.0356 3.5665 1.0634 2.8178 0.1439 0.1647 1.4093 0.0363 1.0463 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 381: 92.1823 -5.8795 -2.1481 -4.2568 -0.9338 0.2204 0.0357 3.5586 1.0635 2.8170 0.1439 0.1648 1.4095 0.0363 1.0456 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 382: 92.1828 -5.8783 -2.1481 -4.2571 -0.9339 0.2203 0.0357 3.5514 1.0636 2.8183 0.1441 0.1649 1.4093 0.0363 1.0462 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 383: 92.1827 -5.8773 -2.1480 -4.2569 -0.9340 0.2202 0.0357 3.5459 1.0633 2.8173 0.1441 0.1650 1.4094 0.0363 1.0465 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 384: 92.1825 -5.8763 -2.1482 -4.2568 -0.9341 0.2202 0.0357 3.5397 1.0636 2.8165 0.1441 0.1650 1.4094 0.0363 1.0467 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 385: 92.1822 -5.8761 -2.1483 -4.2567 -0.9341 0.2201 0.0357 3.5363 1.0641 2.8160 0.1440 0.1650 1.4094 0.0363 1.0469 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 386: 92.1820 -5.8763 -2.1485 -4.2567 -0.9342 0.2200 0.0356 3.5365 1.0645 2.8157 0.1441 0.1648 1.4092 0.0364 1.0478 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 387: 92.1819 -5.8767 -2.1486 -4.2567 -0.9343 0.2201 0.0358 3.5383 1.0652 2.8156 0.1442 0.1646 1.4090 0.0364 1.0480 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 388: 92.1818 -5.8772 -2.1488 -4.2569 -0.9344 0.2202 0.0359 3.5400 1.0656 2.8153 0.1443 0.1645 1.4086 0.0364 1.0480 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 389: 92.1816 -5.8765 -2.1489 -4.2569 -0.9344 0.2203 0.0359 3.5369 1.0660 2.8145 0.1443 0.1644 1.4083 0.0364 1.0476 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 390: 92.1815 -5.8761 -2.1490 -4.2569 -0.9343 0.2205 0.0359 3.5349 1.0664 2.8136 0.1444 0.1644 1.4080 0.0364 1.0472 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 391: 92.1814 -5.8749 -2.1492 -4.2572 -0.9343 0.2207 0.0359 3.5313 1.0668 2.8153 0.1445 0.1643 1.4077 0.0364 1.0465 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 392: 92.1812 -5.8733 -2.1494 -4.2571 -0.9344 0.2210 0.0359 3.5248 1.0674 2.8141 0.1445 0.1642 1.4073 0.0364 1.0457 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 393: 92.1811 -5.8727 -2.1497 -4.2570 -0.9345 0.2212 0.0359 3.5226 1.0679 2.8127 0.1445 0.1642 1.4071 0.0364 1.0457 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 394: 92.1811 -5.8712 -2.1500 -4.2572 -0.9346 0.2214 0.0360 3.5174 1.0684 2.8132 0.1446 0.1641 1.4067 0.0364 1.0456 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 395: 92.1810 -5.8714 -2.1501 -4.2579 -0.9348 0.2217 0.0361 3.5182 1.0685 2.8171 0.1445 0.1641 1.4065 0.0364 1.0452 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 396: 92.1809 -5.8711 -2.1501 -4.2582 -0.9350 0.2220 0.0363 3.5161 1.0681 2.8184 0.1446 0.1639 1.4063 0.0364 1.0447 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 397: 92.1809 -5.8707 -2.1503 -4.2585 -0.9352 0.2222 0.0363 3.5119 1.0684 2.8197 0.1446 0.1637 1.4065 0.0364 1.0442 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 398: 92.1808 -5.8703 -2.1503 -4.2591 -0.9354 0.2224 0.0363 3.5084 1.0689 2.8218 0.1447 0.1634 1.4064 0.0364 1.0445 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 399: 92.1806 -5.8711 -2.1503 -4.2596 -0.9355 0.2226 0.0364 3.5114 1.0691 2.8234 0.1447 0.1629 1.4061 0.0364 1.0447 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 400: 92.1806 -5.8713 -2.1503 -4.2601 -0.9356 0.2229 0.0366 3.5113 1.0695 2.8253 0.1448 0.1626 1.4059 0.0364 1.0440 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 401: 92.1804 -5.8709 -2.1503 -4.2604 -0.9357 0.2231 0.0367 3.5089 1.0696 2.8266 0.1448 0.1624 1.4058 0.0364 1.0440 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 402: 92.1801 -5.8705 -2.1502 -4.2606 -0.9358 0.2232 0.0368 3.5071 1.0695 2.8268 0.1447 0.1621 1.4060 0.0364 1.0447 0.0740</span> -<span class="r-out co"><span class="r-pr">#></span> 403: 92.1800 -5.8708 -2.1503 -4.2610 -0.9359 0.2234 0.0369 3.5083 1.0697 2.8271 0.1447 0.1618 1.4056 0.0365 1.0448 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 404: 92.1798 -5.8709 -2.1505 -4.2612 -0.9360 0.2237 0.0369 3.5085 1.0699 2.8262 0.1447 0.1616 1.4055 0.0365 1.0449 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 405: 92.1795 -5.8705 -2.1503 -4.2613 -0.9360 0.2239 0.0370 3.5059 1.0698 2.8254 0.1448 0.1615 1.4052 0.0364 1.0449 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 406: 92.1792 -5.8710 -2.1504 -4.2613 -0.9359 0.2243 0.0371 3.5069 1.0696 2.8244 0.1449 0.1614 1.4049 0.0364 1.0447 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 407: 92.1788 -5.8718 -2.1505 -4.2614 -0.9359 0.2243 0.0372 3.5092 1.0697 2.8234 0.1449 0.1614 1.4046 0.0364 1.0448 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 408: 92.1786 -5.8729 -2.1505 -4.2615 -0.9360 0.2245 0.0373 3.5140 1.0699 2.8223 0.1449 0.1612 1.4045 0.0365 1.0455 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 409: 92.1784 -5.8740 -2.1506 -4.2615 -0.9360 0.2246 0.0373 3.5192 1.0700 2.8213 0.1450 0.1610 1.4042 0.0365 1.0462 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 410: 92.1782 -5.8753 -2.1505 -4.2616 -0.9361 0.2246 0.0373 3.5248 1.0705 2.8205 0.1450 0.1607 1.4040 0.0365 1.0465 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 411: 92.1780 -5.8758 -2.1503 -4.2619 -0.9362 0.2247 0.0374 3.5249 1.0707 2.8204 0.1449 0.1605 1.4043 0.0364 1.0467 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 412: 92.1778 -5.8759 -2.1502 -4.2621 -0.9363 0.2248 0.0374 3.5238 1.0707 2.8209 0.1448 0.1602 1.4045 0.0364 1.0466 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 413: 92.1779 -5.8759 -2.1501 -4.2623 -0.9364 0.2249 0.0374 3.5225 1.0711 2.8213 0.1448 0.1600 1.4043 0.0364 1.0460 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 414: 92.1781 -5.8754 -2.1500 -4.2622 -0.9364 0.2250 0.0374 3.5205 1.0710 2.8203 0.1448 0.1599 1.4047 0.0364 1.0456 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 415: 92.1781 -5.8750 -2.1499 -4.2623 -0.9363 0.2251 0.0374 3.5187 1.0709 2.8190 0.1448 0.1598 1.4050 0.0364 1.0448 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 416: 92.1783 -5.8747 -2.1500 -4.2624 -0.9363 0.2252 0.0375 3.5216 1.0708 2.8187 0.1448 0.1598 1.4052 0.0364 1.0440 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 417: 92.1783 -5.8738 -2.1500 -4.2625 -0.9362 0.2252 0.0375 3.5219 1.0712 2.8188 0.1447 0.1597 1.4055 0.0364 1.0438 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 418: 92.1784 -5.8735 -2.1501 -4.2627 -0.9360 0.2254 0.0375 3.5222 1.0715 2.8193 0.1448 0.1596 1.4057 0.0364 1.0438 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 419: 92.1784 -5.8725 -2.1501 -4.2629 -0.9358 0.2255 0.0376 3.5190 1.0719 2.8202 0.1447 0.1594 1.4060 0.0364 1.0436 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 420: 92.1785 -5.8713 -2.1500 -4.2633 -0.9357 0.2256 0.0377 3.5152 1.0723 2.8213 0.1447 0.1592 1.4065 0.0364 1.0439 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 421: 92.1786 -5.8697 -2.1500 -4.2639 -0.9355 0.2257 0.0377 3.5100 1.0728 2.8232 0.1448 0.1592 1.4068 0.0364 1.0436 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 422: 92.1787 -5.8683 -2.1502 -4.2645 -0.9352 0.2260 0.0377 3.5051 1.0732 2.8258 0.1448 0.1592 1.4069 0.0364 1.0432 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 423: 92.1788 -5.8667 -2.1504 -4.2653 -0.9350 0.2262 0.0377 3.4992 1.0736 2.8292 0.1448 0.1592 1.4071 0.0364 1.0435 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 424: 92.1789 -5.8659 -2.1505 -4.2661 -0.9349 0.2263 0.0378 3.4972 1.0739 2.8324 0.1448 0.1591 1.4069 0.0364 1.0439 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 425: 92.1788 -5.8649 -2.1505 -4.2669 -0.9349 0.2263 0.0378 3.4947 1.0740 2.8358 0.1448 0.1590 1.4071 0.0364 1.0438 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 426: 92.1788 -5.8643 -2.1506 -4.2677 -0.9348 0.2265 0.0377 3.4922 1.0743 2.8389 0.1448 0.1589 1.4070 0.0365 1.0437 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 427: 92.1785 -5.8637 -2.1506 -4.2683 -0.9347 0.2266 0.0378 3.4895 1.0747 2.8425 0.1448 0.1588 1.4068 0.0365 1.0434 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 428: 92.1783 -5.8627 -2.1507 -4.2689 -0.9347 0.2268 0.0378 3.4870 1.0749 2.8464 0.1447 0.1586 1.4070 0.0365 1.0434 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 429: 92.1782 -5.8617 -2.1509 -4.2696 -0.9347 0.2271 0.0379 3.4845 1.0752 2.8500 0.1446 0.1584 1.4072 0.0365 1.0439 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 430: 92.1783 -5.8608 -2.1510 -4.2701 -0.9347 0.2274 0.0379 3.4830 1.0755 2.8526 0.1446 0.1582 1.4075 0.0365 1.0443 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 431: 92.1784 -5.8606 -2.1511 -4.2704 -0.9348 0.2275 0.0379 3.4825 1.0757 2.8532 0.1446 0.1580 1.4076 0.0365 1.0439 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 432: 92.1784 -5.8610 -2.1512 -4.2707 -0.9350 0.2275 0.0378 3.4833 1.0761 2.8539 0.1447 0.1578 1.4079 0.0365 1.0443 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 433: 92.1783 -5.8618 -2.1512 -4.2711 -0.9351 0.2276 0.0378 3.4867 1.0768 2.8554 0.1447 0.1577 1.4078 0.0366 1.0440 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 434: 92.1784 -5.8612 -2.1513 -4.2714 -0.9350 0.2278 0.0378 3.4858 1.0774 2.8564 0.1448 0.1577 1.4074 0.0365 1.0430 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 435: 92.1783 -5.8610 -2.1513 -4.2718 -0.9348 0.2279 0.0377 3.4874 1.0779 2.8581 0.1448 0.1576 1.4072 0.0366 1.0423 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 436: 92.1781 -5.8610 -2.1513 -4.2721 -0.9346 0.2280 0.0376 3.4879 1.0789 2.8598 0.1448 0.1575 1.4070 0.0365 1.0417 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 437: 92.1781 -5.8610 -2.1511 -4.2726 -0.9345 0.2279 0.0376 3.4886 1.0794 2.8618 0.1449 0.1574 1.4071 0.0365 1.0417 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 438: 92.1781 -5.8609 -2.1510 -4.2730 -0.9345 0.2280 0.0375 3.4893 1.0797 2.8641 0.1449 0.1573 1.4075 0.0365 1.0420 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 439: 92.1781 -5.8608 -2.1509 -4.2734 -0.9343 0.2280 0.0374 3.4894 1.0803 2.8659 0.1449 0.1573 1.4076 0.0365 1.0421 0.0739</span> -<span class="r-out co"><span class="r-pr">#></span> 440: 92.1780 -5.8603 -2.1510 -4.2737 -0.9343 0.2279 0.0374 3.4885 1.0808 2.8674 0.1448 0.1573 1.4079 0.0365 1.0430 0.0738</span> -<span class="r-out co"><span class="r-pr">#></span> 441: 92.1779 -5.8600 -2.1510 -4.2738 -0.9342 0.2279 0.0373 3.4899 1.0811 2.8686 0.1447 0.1574 1.4086 0.0365 1.0445 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 442: 92.1779 -5.8600 -2.1509 -4.2737 -0.9343 0.2278 0.0372 3.4925 1.0814 2.8691 0.1447 0.1575 1.4088 0.0365 1.0451 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 443: 92.1780 -5.8598 -2.1509 -4.2739 -0.9341 0.2278 0.0372 3.4949 1.0819 2.8705 0.1447 0.1576 1.4092 0.0365 1.0453 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 444: 92.1779 -5.8593 -2.1510 -4.2742 -0.9340 0.2277 0.0371 3.4951 1.0824 2.8717 0.1447 0.1576 1.4096 0.0365 1.0455 0.0737</span> -<span class="r-out co"><span class="r-pr">#></span> 445: 92.1777 -5.8593 -2.1511 -4.2744 -0.9338 0.2275 0.0371 3.4999 1.0828 2.8729 0.1448 0.1576 1.4100 0.0365 1.0461 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 446: 92.1774 -5.8600 -2.1511 -4.2748 -0.9338 0.2274 0.0372 3.5051 1.0837 2.8747 0.1449 0.1576 1.4099 0.0365 1.0464 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 447: 92.1771 -5.8604 -2.1512 -4.2751 -0.9338 0.2273 0.0373 3.5087 1.0844 2.8758 0.1449 0.1575 1.4097 0.0365 1.0467 0.0736</span> -<span class="r-out co"><span class="r-pr">#></span> 448: 92.1769 -5.8607 -2.1513 -4.2756 -0.9336 0.2272 0.0374 3.5124 1.0849 2.8778 0.1449 0.1575 1.4098 0.0365 1.0470 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 449: 92.1768 -5.8611 -2.1515 -4.2759 -0.9337 0.2270 0.0374 3.5165 1.0853 2.8789 0.1449 0.1575 1.4101 0.0365 1.0473 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 450: 92.1766 -5.8611 -2.1515 -4.2762 -0.9337 0.2269 0.0374 3.5158 1.0859 2.8800 0.1448 0.1576 1.4102 0.0365 1.0474 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 451: 92.1762 -5.8615 -2.1514 -4.2765 -0.9337 0.2267 0.0374 3.5202 1.0866 2.8812 0.1447 0.1576 1.4104 0.0365 1.0477 0.0735</span> -<span class="r-out co"><span class="r-pr">#></span> 452: 92.1761 -5.8622 -2.1514 -4.2767 -0.9337 0.2264 0.0374 3.5232 1.0871 2.8824 0.1447 0.1576 1.4103 0.0365 1.0479 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 453: 92.1760 -5.8621 -2.1514 -4.2776 -0.9336 0.2261 0.0373 3.5247 1.0878 2.8901 0.1447 0.1576 1.4103 0.0365 1.0480 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 454: 92.1759 -5.8611 -2.1513 -4.2781 -0.9335 0.2259 0.0373 3.5206 1.0882 2.8939 0.1448 0.1575 1.4104 0.0365 1.0483 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 455: 92.1758 -5.8599 -2.1513 -4.2788 -0.9336 0.2258 0.0372 3.5151 1.0887 2.9010 0.1448 0.1575 1.4104 0.0365 1.0485 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 456: 92.1760 -5.8583 -2.1512 -4.2797 -0.9335 0.2258 0.0372 3.5086 1.0892 2.9081 0.1448 0.1574 1.4105 0.0365 1.0483 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 457: 92.1761 -5.8575 -2.1513 -4.2804 -0.9334 0.2257 0.0371 3.5041 1.0896 2.9144 0.1449 0.1574 1.4103 0.0365 1.0480 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 458: 92.1763 -5.8569 -2.1512 -4.2813 -0.9334 0.2257 0.0370 3.5014 1.0901 2.9227 0.1449 0.1574 1.4102 0.0365 1.0476 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 459: 92.1763 -5.8565 -2.1512 -4.2816 -0.9334 0.2256 0.0370 3.4991 1.0908 2.9248 0.1449 0.1573 1.4100 0.0365 1.0471 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 460: 92.1764 -5.8557 -2.1513 -4.2818 -0.9333 0.2256 0.0370 3.4957 1.0915 2.9258 0.1449 0.1572 1.4097 0.0365 1.0466 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 461: 92.1765 -5.8550 -2.1515 -4.2822 -0.9333 0.2255 0.0370 3.4923 1.0921 2.9296 0.1449 0.1571 1.4097 0.0365 1.0464 0.0734</span> -<span class="r-out co"><span class="r-pr">#></span> 462: 92.1764 -5.8546 -2.1517 -4.2824 -0.9333 0.2256 0.0370 3.4897 1.0925 2.9319 0.1448 0.1569 1.4093 0.0365 1.0463 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 463: 92.1763 -5.8539 -2.1519 -4.2830 -0.9333 0.2256 0.0369 3.4863 1.0928 2.9373 0.1449 0.1568 1.4093 0.0366 1.0463 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 464: 92.1763 -5.8532 -2.1520 -4.2833 -0.9333 0.2257 0.0370 3.4825 1.0933 2.9405 0.1448 0.1567 1.4093 0.0366 1.0462 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 465: 92.1762 -5.8528 -2.1521 -4.2837 -0.9335 0.2257 0.0370 3.4795 1.0938 2.9433 0.1448 0.1567 1.4093 0.0366 1.0464 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 466: 92.1762 -5.8530 -2.1523 -4.2840 -0.9336 0.2256 0.0370 3.4780 1.0943 2.9462 0.1448 0.1566 1.4089 0.0366 1.0466 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 467: 92.1764 -5.8529 -2.1524 -4.2846 -0.9337 0.2256 0.0371 3.4751 1.0948 2.9506 0.1447 0.1565 1.4087 0.0366 1.0465 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 468: 92.1765 -5.8531 -2.1525 -4.2849 -0.9337 0.2255 0.0371 3.4734 1.0952 2.9523 0.1447 0.1563 1.4087 0.0366 1.0465 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 469: 92.1767 -5.8533 -2.1525 -4.2853 -0.9337 0.2254 0.0372 3.4754 1.0958 2.9540 0.1447 0.1561 1.4090 0.0366 1.0472 0.0733</span> -<span class="r-out co"><span class="r-pr">#></span> 470: 92.1767 -5.8536 -2.1525 -4.2858 -0.9338 0.2254 0.0373 3.4780 1.0965 2.9571 0.1448 0.1559 1.4094 0.0366 1.0478 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 471: 92.1767 -5.8540 -2.1525 -4.2864 -0.9338 0.2254 0.0373 3.4812 1.0970 2.9606 0.1447 0.1558 1.4099 0.0366 1.0482 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 472: 92.1766 -5.8547 -2.1526 -4.2871 -0.9339 0.2255 0.0373 3.4844 1.0975 2.9645 0.1446 0.1556 1.4101 0.0366 1.0482 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 473: 92.1764 -5.8549 -2.1527 -4.2875 -0.9339 0.2255 0.0373 3.4848 1.0977 2.9672 0.1446 0.1554 1.4100 0.0366 1.0482 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 474: 92.1762 -5.8553 -2.1528 -4.2880 -0.9338 0.2256 0.0373 3.4855 1.0979 2.9700 0.1445 0.1552 1.4104 0.0366 1.0484 0.0732</span> -<span class="r-out co"><span class="r-pr">#></span> 475: 92.1763 -5.8561 -2.1530 -4.2884 -0.9338 0.2256 0.0374 3.4885 1.0981 2.9726 0.1445 0.1549 1.4103 0.0366 1.0484 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 476: 92.1763 -5.8564 -2.1530 -4.2885 -0.9339 0.2258 0.0374 3.4914 1.0983 2.9734 0.1444 0.1548 1.4106 0.0366 1.0484 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 477: 92.1763 -5.8565 -2.1531 -4.2888 -0.9340 0.2259 0.0373 3.4941 1.0985 2.9755 0.1443 0.1546 1.4108 0.0366 1.0487 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 478: 92.1763 -5.8576 -2.1532 -4.2889 -0.9340 0.2258 0.0373 3.4995 1.0987 2.9772 0.1442 0.1544 1.4111 0.0366 1.0490 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 479: 92.1765 -5.8593 -2.1533 -4.2890 -0.9342 0.2259 0.0372 3.5086 1.0990 2.9787 0.1442 0.1544 1.4113 0.0366 1.0495 0.0731</span> -<span class="r-out co"><span class="r-pr">#></span> 480: 92.1766 -5.8613 -2.1535 -4.2892 -0.9342 0.2260 0.0372 3.5233 1.0991 2.9800 0.1442 0.1543 1.4116 0.0367 1.0496 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 481: 92.1768 -5.8624 -2.1536 -4.2894 -0.9341 0.2260 0.0371 3.5309 1.0993 2.9820 0.1442 0.1542 1.4117 0.0367 1.0497 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 482: 92.1766 -5.8634 -2.1537 -4.2896 -0.9341 0.2260 0.0371 3.5393 1.0995 2.9833 0.1443 0.1542 1.4116 0.0367 1.0496 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 483: 92.1762 -5.8645 -2.1538 -4.2896 -0.9340 0.2260 0.0372 3.5472 1.0997 2.9840 0.1443 0.1542 1.4115 0.0367 1.0498 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 484: 92.1757 -5.8648 -2.1538 -4.2896 -0.9340 0.2261 0.0373 3.5508 1.0998 2.9843 0.1445 0.1542 1.4115 0.0366 1.0498 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 485: 92.1752 -5.8648 -2.1539 -4.2896 -0.9340 0.2262 0.0374 3.5516 1.1000 2.9846 0.1445 0.1542 1.4115 0.0366 1.0497 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 486: 92.1747 -5.8649 -2.1539 -4.2897 -0.9340 0.2262 0.0375 3.5517 1.1003 2.9856 0.1446 0.1541 1.4113 0.0366 1.0498 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 487: 92.1743 -5.8649 -2.1539 -4.2896 -0.9340 0.2262 0.0376 3.5502 1.1006 2.9856 0.1447 0.1539 1.4110 0.0367 1.0498 0.0730</span> -<span class="r-out co"><span class="r-pr">#></span> 488: 92.1739 -5.8645 -2.1540 -4.2893 -0.9340 0.2261 0.0377 3.5475 1.1008 2.9848 0.1447 0.1537 1.4106 0.0367 1.0497 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 489: 92.1736 -5.8640 -2.1539 -4.2892 -0.9340 0.2260 0.0376 3.5445 1.1011 2.9844 0.1448 0.1536 1.4105 0.0367 1.0496 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 490: 92.1736 -5.8631 -2.1539 -4.2889 -0.9340 0.2260 0.0376 3.5402 1.1014 2.9835 0.1448 0.1534 1.4103 0.0366 1.0496 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 491: 92.1735 -5.8617 -2.1539 -4.2887 -0.9339 0.2260 0.0375 3.5343 1.1016 2.9825 0.1449 0.1532 1.4103 0.0366 1.0497 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 492: 92.1736 -5.8609 -2.1539 -4.2884 -0.9339 0.2259 0.0375 3.5298 1.1017 2.9816 0.1449 0.1530 1.4101 0.0367 1.0499 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 493: 92.1737 -5.8605 -2.1539 -4.2882 -0.9339 0.2260 0.0375 3.5266 1.1018 2.9807 0.1450 0.1529 1.4098 0.0367 1.0496 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 494: 92.1739 -5.8609 -2.1539 -4.2881 -0.9340 0.2261 0.0375 3.5273 1.1018 2.9802 0.1450 0.1528 1.4097 0.0367 1.0495 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 495: 92.1741 -5.8614 -2.1540 -4.2880 -0.9340 0.2262 0.0376 3.5290 1.1019 2.9797 0.1450 0.1526 1.4096 0.0367 1.0492 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 496: 92.1742 -5.8623 -2.1540 -4.2879 -0.9341 0.2262 0.0376 3.5348 1.1020 2.9791 0.1449 0.1525 1.4096 0.0367 1.0491 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 497: 92.1742 -5.8634 -2.1541 -4.2879 -0.9341 0.2264 0.0377 3.5402 1.1020 2.9789 0.1449 0.1524 1.4097 0.0367 1.0493 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 498: 92.1744 -5.8637 -2.1543 -4.2879 -0.9341 0.2266 0.0377 3.5406 1.1019 2.9787 0.1449 0.1524 1.4096 0.0367 1.0496 0.0729</span> -<span class="r-out co"><span class="r-pr">#></span> 499: 92.1744 -5.8635 -2.1544 -4.2880 -0.9341 0.2268 0.0376 3.5400 1.1019 2.9789 0.1450 0.1523 1.4095 0.0367 1.0500 0.0728</span> -<span class="r-out co"><span class="r-pr">#></span> 500: 92.1744 -5.8628 -2.1545 -4.2882 -0.9341 0.2270 0.0377 3.5381 1.1020 2.9795 0.1450 0.1522 1.4096 0.0367 1.0503 0.0728</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei_obs_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_tc</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, est <span class="op">=</span> <span class="st">"focei"</span>,</span> -<span class="r-in"> error_model <span class="op">=</span> <span class="st">"obs_tc"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_A1 |f_parent_qlogis | log_k1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis |sigma_low_parent |rsd_high_parent |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................|sigma_low_A1 |rsd_high_A1 | o1 | o2 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o3 | o4 | o5 | o6 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 495.48573 | 1.000 | -1.000 | -0.9104 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9875 | -0.8823 | -0.8746 | -0.8907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8746 | -0.8907 | -0.8767 | -0.8731 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8673 | -0.8720 | -0.8739 | -0.8666 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.48573 | 91.00 | -5.200 | -0.8900 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.600 | 0.4600 | 0.8300 | 0.05800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.05800 | 0.7311 | 0.9036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.183 | 0.9554 | 0.8633 | 1.214 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.48573</span> | 91.00 | 0.005517 | 0.2911 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01005 | 0.6130 | 0.8300 | 0.05800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8300 | 0.05800 | 0.7311 | 0.9036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.183 | 0.9554 | 0.8633 | 1.214 |</span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -0.9648 | 2.223 | -0.3153 | -0.01817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3350 | 0.6789 | -23.42 | -17.64 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -5.440 | -1.950 | 0.9642 | 9.851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -11.94 | -1.319 | 8.578 | -12.45 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 481.75012 | 1.026 | -1.060 | -0.9019 | -0.9371 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9785 | -0.9007 | -0.2420 | -0.4142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7277 | -0.8380 | -0.9027 | -1.139 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8364 | -1.106 | -0.5303 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.75012 | 93.37 | -5.260 | -0.8824 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4516 | 1.093 | 0.07182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8910 | 0.05953 | 0.7121 | 0.6631 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9895 | 0.6633 | 1.623 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.75012</span> | 93.37 | 0.005195 | 0.2927 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.093 | 0.07182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8910 | 0.05953 | 0.7121 | 0.6631 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9895 | 0.6633 | 1.623 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 152.5 | 1.317 | 3.315 | -0.1772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3391 | 0.1426 | -4.513 | 6.696 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.211 | 0.7988 | 0.6299 | -5.324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009964 | 3.044 | -5.727 | -6.694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 3004.9713 | 0.2745 | -1.093 | -0.9147 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9762 | -0.9095 | 0.05941 | -0.2377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6690 | -0.8188 | -0.9174 | -1.204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4027 | -0.8359 | -1.205 | -0.3486 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 3004.9713 | 24.98 | -5.293 | -0.8938 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.589 | 0.4475 | 1.218 | 0.07694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9154 | 0.06008 | 0.7014 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.733 | 0.9899 | 0.5774 | 1.843 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 3004.9713</span> | 24.98 | 0.005026 | 0.2903 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01017 | 0.6100 | 1.218 | 0.07694 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9154 | 0.06008 | 0.7014 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.733 | 0.9899 | 0.5774 | 1.843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 491.68825 | 0.9393 | -1.061 | -0.9038 | -0.9370 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9787 | -0.9008 | -0.2394 | -0.4180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7284 | -0.8385 | -0.9031 | -1.136 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8381 | -1.102 | -0.5265 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.68825 | 85.47 | -5.261 | -0.8841 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4515 | 1.094 | 0.07171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05951 | 0.7118 | 0.6659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9878 | 0.6661 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.68825</span> | 85.47 | 0.005191 | 0.2923 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.094 | 0.07171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05951 | 0.7118 | 0.6659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9878 | 0.6661 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 479.72282 | 1.001 | -1.060 | -0.9024 | -0.9371 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9785 | -0.9007 | -0.2413 | -0.4153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7279 | -0.8381 | -0.9028 | -1.138 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5448 | -0.8369 | -1.105 | -0.5292 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.72282 | 91.11 | -5.260 | -0.8829 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.4516 | 1.093 | 0.07179 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8909 | 0.05952 | 0.7120 | 0.6639 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9890 | 0.6641 | 1.624 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.72282</span> | 91.11 | 0.005194 | 0.2926 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.093 | 0.07179 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8909 | 0.05952 | 0.7120 | 0.6639 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9890 | 0.6641 | 1.624 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.589 | 1.222 | 0.9137 | 0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3993 | 0.5206 | -3.904 | 6.654 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9090 | 1.134 | -1.839 | -6.108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 4.007 | -4.921 | -6.374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 479.56384 | 0.9950 | -1.061 | -0.9037 | -0.9373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9792 | -0.9012 | -0.2438 | -0.4298 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7309 | -0.8403 | -0.9001 | -1.126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5509 | -0.8426 | -1.095 | -0.5241 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.56384 | 90.55 | -5.261 | -0.8840 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4513 | 1.092 | 0.07137 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8897 | 0.05946 | 0.7140 | 0.6748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9836 | 0.6729 | 1.630 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.56384</span> | 90.55 | 0.005189 | 0.2923 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.6110 | 1.092 | 0.07137 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8897 | 0.05946 | 0.7140 | 0.6748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9836 | 0.6729 | 1.630 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -31.71 | 1.225 | 0.1963 | 0.1681 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4113 | 0.6853 | -4.208 | 6.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7033 | 1.163 | -2.029 | -4.071 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.106 | 3.494 | -3.921 | -6.098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 479.23599 | 1.003 | -1.063 | -0.9048 | -0.9375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9799 | -0.9023 | -0.2352 | -0.4403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7320 | -0.8422 | -0.8974 | -1.117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5472 | -0.8484 | -1.086 | -0.5115 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.23599 | 91.29 | -5.263 | -0.8850 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.4508 | 1.095 | 0.07106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8892 | 0.05941 | 0.7160 | 0.6828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9781 | 0.6800 | 1.645 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.23599</span> | 91.29 | 0.005177 | 0.2921 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.6108 | 1.095 | 0.07106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8892 | 0.05941 | 0.7160 | 0.6828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9781 | 0.6800 | 1.645 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 18.36 | 1.286 | 0.8956 | 0.06941 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3942 | 0.6495 | -3.460 | 6.349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7828 | 0.9998 | -1.947 | -2.931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1591 | 2.144 | -3.375 | -5.909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 479.05200 | 0.9982 | -1.066 | -0.9056 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9803 | -0.9037 | -0.2181 | -0.4407 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7304 | -0.8427 | -0.8951 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5384 | -0.8504 | -1.087 | -0.4972 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.052 | 90.84 | -5.266 | -0.8857 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4502 | 1.102 | 0.07105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8899 | 0.05939 | 0.7177 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9761 | 0.6797 | 1.663 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.052</span> | 90.84 | 0.005162 | 0.2920 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6107 | 1.102 | 0.07105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8899 | 0.05939 | 0.7177 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9761 | 0.6797 | 1.663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 478.91507 | 0.9977 | -1.070 | -0.9061 | -0.9377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9807 | -0.9051 | -0.2002 | -0.4395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7284 | -0.8431 | -0.8930 | -1.121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5287 | -0.8520 | -1.088 | -0.4828 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.91507 | 90.79 | -5.270 | -0.8862 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.593 | 0.4495 | 1.110 | 0.07109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05938 | 0.7192 | 0.6799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9745 | 0.6785 | 1.680 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.91507</span> | 90.79 | 0.005146 | 0.2919 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01012 | 0.6105 | 1.110 | 0.07109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8907 | 0.05938 | 0.7192 | 0.6799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9745 | 0.6785 | 1.680 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 478.54700 | 0.9959 | -1.080 | -0.9081 | -0.9381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9820 | -0.9099 | -0.1391 | -0.4353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7215 | -0.8442 | -0.8862 | -1.128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4957 | -0.8577 | -1.093 | -0.4342 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.547 | 90.63 | -5.280 | -0.8880 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.594 | 0.4473 | 1.135 | 0.07121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8936 | 0.05935 | 0.7242 | 0.6734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9691 | 0.6746 | 1.739 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.547</span> | 90.63 | 0.005094 | 0.2915 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01011 | 0.6100 | 1.135 | 0.07121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8936 | 0.05935 | 0.7242 | 0.6734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9691 | 0.6746 | 1.739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 478.24707 | 0.9926 | -1.098 | -0.9118 | -0.9388 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9843 | -0.9186 | -0.02735 | -0.4276 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7088 | -0.8464 | -0.8736 | -1.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4354 | -0.8680 | -1.101 | -0.3451 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.24707 | 90.33 | -5.298 | -0.8913 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.597 | 0.4433 | 1.182 | 0.07143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8988 | 0.05929 | 0.7334 | 0.6616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.694 | 0.9593 | 0.6674 | 1.848 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.24707</span> | 90.33 | 0.004999 | 0.2909 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01008 | 0.6090 | 1.182 | 0.07143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8988 | 0.05929 | 0.7334 | 0.6616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.694 | 0.9593 | 0.6674 | 1.848 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -54.86 | 1.159 | -0.2545 | 0.1198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4779 | 1.320 | -1.627 | 7.719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 1.194 | -2.008 | -4.434 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.563 | 0.8010 | -2.393 | -3.495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 475.90466 | 1.002 | -1.127 | -0.9233 | -0.9398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9978 | -0.9482 | -0.05448 | -0.6822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7579 | -0.8801 | -0.8190 | -1.095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4550 | -0.8498 | -1.031 | -0.2699 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.90466 | 91.18 | -5.327 | -0.9014 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.610 | 0.4297 | 1.170 | 0.06405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05831 | 0.7733 | 0.7032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.671 | 0.9767 | 0.7277 | 1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.90466</span> | 91.18 | 0.004860 | 0.2888 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009950 | 0.6058 | 1.170 | 0.06405 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05831 | 0.7733 | 0.7032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.671 | 0.9767 | 0.7277 | 1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.773 | 1.281 | 0.05418 | -0.06269 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4104 | 1.812 | -4.981 | 3.640 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08126 | 0.09477 | -1.092 | -2.966 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.262 | 2.712 | 3.245 | -2.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 477.06760 | 1.030 | -1.176 | -0.9281 | -0.9377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.011 | 0.09564 | -0.8420 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7668 | -0.8907 | -0.7738 | -1.073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5619 | -0.8693 | -1.126 | -0.1773 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.0676 | 93.71 | -5.376 | -0.9057 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4008 | 1.233 | 0.05941 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8748 | 0.05800 | 0.8064 | 0.7234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.545 | 0.9581 | 0.6461 | 2.051 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.0676</span> | 93.71 | 0.004627 | 0.2879 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009799 | 0.5989 | 1.233 | 0.05941 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8748 | 0.05800 | 0.8064 | 0.7234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.545 | 0.9581 | 0.6461 | 2.051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 477.20174 | 1.026 | -1.143 | -0.9246 | -0.9391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9695 | -0.001726 | -0.7335 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8831 | -0.8043 | -1.080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4976 | -0.8627 | -1.065 | -0.2404 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.20174 | 93.37 | -5.343 | -0.9027 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4199 | 1.192 | 0.06256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05822 | 0.7840 | 0.7162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.621 | 0.9644 | 0.6988 | 1.975 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.20174</span> | 93.37 | 0.004782 | 0.2885 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009899 | 0.6035 | 1.192 | 0.06256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05822 | 0.7840 | 0.7162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.621 | 0.9644 | 0.6988 | 1.975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 476.22973 | 1.014 | -1.129 | -0.9234 | -0.9397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9986 | -0.9521 | -0.04396 | -0.6899 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7577 | -0.8803 | -0.8167 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4661 | -0.8555 | -1.038 | -0.2656 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.22973 | 92.29 | -5.329 | -0.9015 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4279 | 1.175 | 0.06382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7750 | 0.7089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9712 | 0.7218 | 1.944 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.22973</span> | 92.29 | 0.004847 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009941 | 0.6054 | 1.175 | 0.06382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7750 | 0.7089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9712 | 0.7218 | 1.944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 475.87776 | 1.005 | -1.127 | -0.9233 | -0.9398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9980 | -0.9491 | -0.05201 | -0.6840 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7578 | -0.8802 | -0.8184 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4576 | -0.8511 | -1.033 | -0.2689 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.87776 | 91.44 | -5.327 | -0.9015 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.610 | 0.4293 | 1.171 | 0.06399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7737 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.668 | 0.9754 | 0.7263 | 1.940 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.87776</span> | 91.44 | 0.004857 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009948 | 0.6057 | 1.171 | 0.06399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8785 | 0.05830 | 0.7737 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.668 | 0.9754 | 0.7263 | 1.940 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.12 | 1.298 | 0.4116 | -0.09723 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4002 | 1.728 | -4.991 | 3.781 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06392 | 0.04117 | -1.251 | -0.6787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.079 | 2.620 | 3.013 | -2.074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 475.82399 | 1.002 | -1.128 | -0.9234 | -0.9397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9982 | -0.9501 | -0.04950 | -0.6866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7580 | -0.8803 | -0.8177 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4596 | -0.8518 | -1.034 | -0.2675 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.82399 | 91.17 | -5.328 | -0.9016 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4288 | 1.172 | 0.06392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7743 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.666 | 0.9748 | 0.7251 | 1.942 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.82399</span> | 91.17 | 0.004853 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009945 | 0.6056 | 1.172 | 0.06392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7743 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.666 | 0.9748 | 0.7251 | 1.942 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.267 | 1.279 | 0.007095 | -0.05940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4115 | 1.783 | -5.114 | 3.652 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1068 | 0.1083 | -1.295 | -0.9578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.682 | 2.514 | 3.014 | -2.035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 475.78862 | 1.005 | -1.129 | -0.9235 | -0.9397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9985 | -0.9512 | -0.04657 | -0.6892 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7580 | -0.8804 | -0.8168 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4611 | -0.8527 | -1.036 | -0.2661 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.78862 | 91.41 | -5.329 | -0.9016 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4283 | 1.174 | 0.06384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7749 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.664 | 0.9739 | 0.7236 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.78862</span> | 91.41 | 0.004849 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009942 | 0.6055 | 1.174 | 0.06384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8784 | 0.05830 | 0.7749 | 0.7045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.664 | 0.9739 | 0.7236 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.19 | 1.292 | 0.3498 | -0.09321 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4023 | 1.703 | -5.372 | 3.699 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1234 | 0.05429 | -1.241 | -0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.815 | 2.436 | 2.783 | -2.083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 475.73531 | 1.002 | -1.130 | -0.9236 | -0.9397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9987 | -0.9524 | -0.04361 | -0.6921 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7582 | -0.8806 | -0.8159 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4630 | -0.8531 | -1.037 | -0.2646 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.73531 | 91.21 | -5.330 | -0.9018 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4278 | 1.175 | 0.06376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7756 | 0.7041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.662 | 0.9735 | 0.7222 | 1.945 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.73531</span> | 91.21 | 0.004845 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009940 | 0.6053 | 1.175 | 0.06376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7756 | 0.7041 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.662 | 0.9735 | 0.7222 | 1.945 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.312 | 1.277 | 0.06663 | -0.06695 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4102 | 1.736 | -5.095 | 3.555 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08175 | 0.08515 | -1.253 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.836 | 2.452 | 2.739 | -2.058 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 475.69941 | 1.004 | -1.131 | -0.9237 | -0.9396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9990 | -0.9534 | -0.04063 | -0.6942 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7581 | -0.8807 | -0.8151 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4658 | -0.8545 | -1.039 | -0.2634 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.69941 | 91.39 | -5.331 | -0.9018 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.611 | 0.4273 | 1.176 | 0.06370 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7761 | 0.7046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9722 | 0.7208 | 1.947 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.69941</span> | 91.39 | 0.004841 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009937 | 0.6052 | 1.176 | 0.06370 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7761 | 0.7046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.658 | 0.9722 | 0.7208 | 1.947 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.57 | 1.287 | 0.3079 | -0.08979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4039 | 1.674 | -5.153 | 3.653 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06063 | 0.04440 | -1.200 | -0.7646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.452 | 2.339 | 2.552 | -2.095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 475.66307 | 1.001 | -1.131 | -0.9238 | -0.9396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9992 | -0.9545 | -0.03780 | -0.6969 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7583 | -0.8808 | -0.8143 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4671 | -0.8550 | -1.041 | -0.2620 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.66307 | 91.11 | -5.331 | -0.9019 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4268 | 1.177 | 0.06362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7767 | 0.7044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.657 | 0.9717 | 0.7195 | 1.948 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.66307</span> | 91.11 | 0.004837 | 0.2887 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009935 | 0.6051 | 1.177 | 0.06362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8783 | 0.05829 | 0.7767 | 0.7044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.657 | 0.9717 | 0.7195 | 1.948 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.57 | 1.267 | -0.09715 | -0.05310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4138 | 1.728 | -5.558 | 3.438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1081 | 0.1203 | -1.232 | -1.053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.344 | 2.291 | 2.543 | -2.059 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 475.61346 | 1.003 | -1.132 | -0.9238 | -0.9395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9995 | -0.9557 | -0.03467 | -0.6999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7585 | -0.8810 | -0.8134 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4680 | -0.8550 | -1.042 | -0.2607 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.61346 | 91.32 | -5.332 | -0.9020 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4262 | 1.179 | 0.06353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7774 | 0.7040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.656 | 0.9717 | 0.7181 | 1.950 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.61346</span> | 91.32 | 0.004833 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009932 | 0.6050 | 1.179 | 0.06353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7774 | 0.7040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.656 | 0.9717 | 0.7181 | 1.950 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.192 | 1.277 | 0.1967 | -0.08157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4060 | 1.656 | -5.231 | 3.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1038 | 0.05786 | -1.199 | -0.8859 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.283 | 2.293 | 2.331 | -2.101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 475.58436 | 1.001 | -1.133 | -0.9239 | -0.9395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9998 | -0.9568 | -0.03140 | -0.7025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7585 | -0.8810 | -0.8126 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4692 | -0.8560 | -1.044 | -0.2594 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.58436 | 91.09 | -5.333 | -0.9021 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.612 | 0.4257 | 1.180 | 0.06346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7780 | 0.7043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.654 | 0.9707 | 0.7167 | 1.952 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.58436</span> | 91.09 | 0.004829 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009929 | 0.6049 | 1.180 | 0.06346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8782 | 0.05828 | 0.7780 | 0.7043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.654 | 0.9707 | 0.7167 | 1.952 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.46 | 1.261 | -0.1306 | -0.05131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4140 | 1.696 | -5.518 | 3.404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1407 | 0.1181 | -1.199 | -1.071 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.272 | 2.212 | 2.296 | -2.075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 475.53229 | 1.003 | -1.134 | -0.9240 | -0.9394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9581 | -0.02828 | -0.7055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7587 | -0.8812 | -0.8117 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4701 | -0.8560 | -1.045 | -0.2580 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.53229 | 91.31 | -5.334 | -0.9021 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4251 | 1.181 | 0.06337 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7786 | 0.7039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.653 | 0.9708 | 0.7153 | 1.953 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.53229</span> | 91.31 | 0.004824 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009926 | 0.6047 | 1.181 | 0.06337 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7786 | 0.7039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.653 | 0.9708 | 0.7153 | 1.953 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.355 | 1.271 | 0.1786 | -0.08149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4055 | 1.621 | -5.117 | 3.557 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1060 | 0.04285 | -0.9518 | -2.902 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.469 | 2.204 | 2.093 | -2.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 475.50379 | 1.001 | -1.135 | -0.9241 | -0.9394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9591 | -0.02533 | -0.7076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7587 | -0.8812 | -0.8111 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4726 | -0.8571 | -1.047 | -0.2568 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.50379 | 91.10 | -5.335 | -0.9022 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4247 | 1.182 | 0.06331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7790 | 0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | 0.9697 | 0.7143 | 1.955 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.50379</span> | 91.10 | 0.004820 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009924 | 0.6046 | 1.182 | 0.06331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05828 | 0.7790 | 0.7053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | 0.9697 | 0.7143 | 1.955 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.73 | 1.259 | -0.1294 | -0.05234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4131 | 1.659 | -5.626 | 3.356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1179 | 0.1182 | -1.163 | -0.9759 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.282 | 2.162 | 2.085 | -2.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 475.45890 | 1.004 | -1.136 | -0.9240 | -0.9393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9602 | -0.02221 | -0.7103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7588 | -0.8813 | -0.8104 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4738 | -0.8571 | -1.048 | -0.2555 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.4589 | 91.37 | -5.336 | -0.9021 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4242 | 1.184 | 0.06323 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05827 | 0.7796 | 0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.649 | 0.9697 | 0.7132 | 1.956 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.4589</span> | 91.37 | 0.004816 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009921 | 0.6045 | 1.184 | 0.06323 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8781 | 0.05827 | 0.7796 | 0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.649 | 0.9697 | 0.7132 | 1.956 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.388 | 1.275 | 0.2447 | -0.08891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4027 | 1.576 | -4.598 | 3.539 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08390 | 0.04261 | -0.9004 | -2.725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.305 | 2.111 | 1.882 | -2.135 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 475.41657 | 1.002 | -1.137 | -0.9241 | -0.9392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9615 | -0.01910 | -0.7133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7590 | -0.8814 | -0.8097 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4754 | -0.8571 | -1.049 | -0.2540 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.41657 | 91.17 | -5.337 | -0.9022 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.613 | 0.4236 | 1.185 | 0.06314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7801 | 0.7060 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.647 | 0.9697 | 0.7121 | 1.958 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.41657</span> | 91.17 | 0.004811 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009918 | 0.6043 | 1.185 | 0.06314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7801 | 0.7060 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.647 | 0.9697 | 0.7121 | 1.958 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.291 | 1.263 | -0.02799 | -0.06240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4098 | 1.607 | -5.561 | 3.409 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1363 | 0.09124 | -1.126 | -0.9025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.264 | 2.123 | 1.858 | -2.103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 475.37603 | 1.004 | -1.138 | -0.9241 | -0.9392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.001 | -0.9626 | -0.01569 | -0.7160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7590 | -0.8815 | -0.8090 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4775 | -0.8574 | -1.050 | -0.2525 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.37603 | 91.35 | -5.338 | -0.9022 | -2.202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4231 | 1.186 | 0.06307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7806 | 0.7060 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.645 | 0.9695 | 0.7112 | 1.960 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.37603</span> | 91.35 | 0.004807 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009915 | 0.6042 | 1.186 | 0.06307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8780 | 0.05827 | 0.7806 | 0.7060 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.645 | 0.9695 | 0.7112 | 1.960 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.976 | 1.271 | 0.2167 | -0.08766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4024 | 1.550 | -5.132 | 3.516 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09627 | 0.04106 | -1.088 | -0.7404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.103 | 2.126 | 1.707 | -2.133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 475.34297 | 1.001 | -1.139 | -0.9242 | -0.9391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9636 | -0.01242 | -0.7185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7591 | -0.8816 | -0.8082 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4796 | -0.8578 | -1.051 | -0.2511 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.34297 | 91.13 | -5.339 | -0.9023 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4226 | 1.188 | 0.06299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7812 | 0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.642 | 0.9691 | 0.7103 | 1.962 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.34297</span> | 91.13 | 0.004803 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009912 | 0.6041 | 1.188 | 0.06299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7812 | 0.7056 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.642 | 0.9691 | 0.7103 | 1.962 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.69 | 1.251 | -0.09758 | -0.05188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4100 | 1.596 | -5.544 | 3.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1288 | 0.09302 | -1.103 | -0.9943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.044 | 2.113 | 1.726 | -2.096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 475.29763 | 1.004 | -1.140 | -0.9242 | -0.9391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9647 | -0.009016 | -0.7212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7592 | -0.8817 | -0.8074 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4815 | -0.8578 | -1.052 | -0.2496 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.29763 | 91.33 | -5.340 | -0.9023 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.614 | 0.4221 | 1.189 | 0.06292 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7818 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.640 | 0.9691 | 0.7096 | 1.964 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.29763</span> | 91.33 | 0.004798 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009909 | 0.6040 | 1.189 | 0.06292 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7818 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.640 | 0.9691 | 0.7096 | 1.964 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.626 | 1.261 | 0.1834 | -0.08674 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4019 | 1.535 | -5.612 | 3.466 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1091 | 0.03444 | -1.082 | -0.8814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.882 | 2.084 | 1.576 | -2.128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 475.26968 | 1.001 | -1.140 | -0.9243 | -0.9390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9656 | -0.005554 | -0.7235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7592 | -0.8818 | -0.8067 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4837 | -0.8585 | -1.053 | -0.2482 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.26968 | 91.11 | -5.340 | -0.9024 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4217 | 1.191 | 0.06285 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7823 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.637 | 0.9684 | 0.7088 | 1.965 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.26968</span> | 91.11 | 0.004794 | 0.2886 | 0.1106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009907 | 0.6039 | 1.191 | 0.06285 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8779 | 0.05826 | 0.7823 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.637 | 0.9684 | 0.7088 | 1.965 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.71 | 1.246 | -0.1255 | -0.05322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4099 | 1.581 | -5.546 | 3.317 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1509 | 0.1096 | -0.8594 | -3.000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.990 | 2.056 | 1.604 | -2.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 475.22190 | 1.004 | -1.141 | -0.9243 | -0.9390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.002 | -0.9667 | -0.002058 | -0.7261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7593 | -0.8819 | -0.8061 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4854 | -0.8583 | -1.054 | -0.2469 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.2219 | 91.33 | -5.341 | -0.9024 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4212 | 1.192 | 0.06277 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05826 | 0.7828 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.635 | 0.9686 | 0.7081 | 1.967 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.2219</span> | 91.33 | 0.004790 | 0.2886 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009904 | 0.6038 | 1.192 | 0.06277 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05826 | 0.7828 | 0.7049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.635 | 0.9686 | 0.7081 | 1.967 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.841 | 1.258 | 0.1840 | -0.08823 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4011 | 1.514 | -4.992 | 3.441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1080 | 0.03852 | -1.043 | -0.8514 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.826 | 2.019 | 1.451 | -2.125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 475.19540 | 1.001 | -1.142 | -0.9244 | -0.9389 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9677 | 0.001228 | -0.7286 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7593 | -0.8819 | -0.8054 | -1.093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4876 | -0.8589 | -1.055 | -0.2455 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.1954 | 91.10 | -5.342 | -0.9025 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4207 | 1.193 | 0.06270 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7833 | 0.7050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.633 | 0.9680 | 0.7073 | 1.969 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.1954</span> | 91.10 | 0.004786 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009901 | 0.6037 | 1.193 | 0.06270 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7833 | 0.7050 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.633 | 0.9680 | 0.7073 | 1.969 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.17 | 1.239 | -0.1323 | -0.05443 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4093 | 1.561 | -5.475 | 3.262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1301 | 0.09817 | -1.038 | -1.045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.818 | 2.054 | 1.474 | -2.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 475.14668 | 1.003 | -1.143 | -0.9244 | -0.9388 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9688 | 0.004635 | -0.7312 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8820 | -0.8046 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4894 | -0.8588 | -1.055 | -0.2440 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.14668 | 91.31 | -5.343 | -0.9025 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.615 | 0.4202 | 1.195 | 0.06262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7838 | 0.7043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.631 | 0.9681 | 0.7066 | 1.970 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.14668</span> | 91.31 | 0.004781 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009898 | 0.6035 | 1.195 | 0.06262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7838 | 0.7043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.631 | 0.9681 | 0.7066 | 1.970 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.838 | 1.251 | 0.1547 | -0.08725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4006 | 1.498 | -4.927 | 3.416 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1219 | 0.06473 | -1.010 | -2.917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.712 | 2.020 | 1.337 | -2.117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 475.12366 | 1.001 | -1.144 | -0.9245 | -0.9388 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9698 | 0.007665 | -0.7333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7594 | -0.8821 | -0.8040 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4916 | -0.8600 | -1.056 | -0.2427 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.12366 | 91.10 | -5.344 | -0.9025 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4198 | 1.196 | 0.06256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7843 | 0.7059 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.628 | 0.9669 | 0.7059 | 1.972 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.12366</span> | 91.10 | 0.004777 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009896 | 0.6034 | 1.196 | 0.06256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7843 | 0.7059 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.628 | 0.9669 | 0.7059 | 1.972 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.75 | 1.239 | -0.1466 | -0.05465 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4082 | 1.541 | -5.471 | 3.270 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1342 | 0.09829 | -1.014 | -1.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.624 | 1.932 | 1.359 | -2.081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 475.07465 | 1.004 | -1.145 | -0.9245 | -0.9387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.003 | -0.9709 | 0.01108 | -0.7360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8821 | -0.8033 | -1.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4933 | -0.8597 | -1.057 | -0.2414 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.07465 | 91.33 | -5.345 | -0.9025 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4193 | 1.198 | 0.06248 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7848 | 0.7058 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.626 | 0.9672 | 0.7053 | 1.974 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.07465</span> | 91.33 | 0.004773 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009893 | 0.6033 | 1.198 | 0.06248 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7848 | 0.7058 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.626 | 0.9672 | 0.7053 | 1.974 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.021 | 1.249 | 0.1599 | -0.08992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3985 | 1.471 | -4.995 | 3.410 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1196 | 0.03779 | -0.9990 | -2.873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.497 | 1.906 | 1.211 | -2.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 475.04940 | 1.001 | -1.146 | -0.9245 | -0.9386 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9719 | 0.01438 | -0.7384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7594 | -0.8822 | -0.8026 | -1.091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4953 | -0.8604 | -1.058 | -0.2400 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.0494 | 91.11 | -5.346 | -0.9026 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.616 | 0.4188 | 1.199 | 0.06242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7853 | 0.7070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9666 | 0.7046 | 1.975 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.0494</span> | 91.11 | 0.004769 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009890 | 0.6032 | 1.199 | 0.06242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7853 | 0.7070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.623 | 0.9666 | 0.7046 | 1.975 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.15 | 1.235 | -0.1370 | -0.05688 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4085 | 1.517 | -5.494 | 3.160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1583 | 0.1112 | -0.7821 | -2.927 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.432 | 1.909 | 1.245 | -2.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 475.00092 | 1.004 | -1.147 | -0.9245 | -0.9386 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9731 | 0.01792 | -0.7411 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8822 | -0.8020 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4968 | -0.8598 | -1.059 | -0.2387 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.00092 | 91.32 | -5.347 | -0.9025 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4182 | 1.200 | 0.06234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7857 | 0.7077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 0.9671 | 0.7039 | 1.977 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.00092</span> | 91.32 | 0.004764 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009887 | 0.6031 | 1.200 | 0.06234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7857 | 0.7077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.622 | 0.9671 | 0.7039 | 1.977 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.379 | 1.249 | 0.1419 | -0.08698 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3989 | 1.449 | -4.966 | 3.395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1055 | 0.03295 | -0.9696 | -0.7580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.283 | 1.918 | 1.096 | -2.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 474.98492 | 1.001 | -1.147 | -0.9246 | -0.9385 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.004 | -0.9740 | 0.02115 | -0.7433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7595 | -0.8822 | -0.8014 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4989 | -0.8610 | -1.059 | -0.2373 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.98492 | 91.07 | -5.347 | -0.9026 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4178 | 1.202 | 0.06227 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7862 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 0.9660 | 0.7033 | 1.978 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.98492</span> | 91.07 | 0.004760 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009884 | 0.6030 | 1.202 | 0.06227 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05825 | 0.7862 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 0.9660 | 0.7033 | 1.978 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.65 | 1.231 | -0.1920 | -0.05242 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4084 | 1.504 | -5.397 | 3.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1354 | 0.1061 | -0.9468 | -0.9144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.271 | 1.859 | 1.156 | -2.067 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 474.93249 | 1.004 | -1.148 | -0.9245 | -0.9384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9752 | 0.02452 | -0.7460 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.8007 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5000 | -0.8607 | -1.060 | -0.2361 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.93249 | 91.32 | -5.348 | -0.9026 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4173 | 1.203 | 0.06220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05824 | 0.7867 | 0.7073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.618 | 0.9663 | 0.7027 | 1.980 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.93249</span> | 91.32 | 0.004755 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009881 | 0.6028 | 1.203 | 0.06220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8778 | 0.05824 | 0.7867 | 0.7073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.618 | 0.9663 | 0.7027 | 1.980 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.492 | 1.243 | 0.1448 | -0.09052 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3963 | 1.427 | -4.973 | 3.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06414 | 0.02300 | -0.7344 | -2.787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.083 | 1.834 | 0.9813 | -2.110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 474.90355 | 1.001 | -1.149 | -0.9246 | -0.9383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9763 | 0.02806 | -0.7486 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.8002 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5018 | -0.8611 | -1.061 | -0.2347 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.90355 | 91.13 | -5.349 | -0.9026 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.617 | 0.4168 | 1.205 | 0.06212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7870 | 0.7084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.616 | 0.9659 | 0.7020 | 1.982 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.90355</span> | 91.13 | 0.004751 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009878 | 0.6027 | 1.205 | 0.06212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7870 | 0.7084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.616 | 0.9659 | 0.7020 | 1.982 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.15 | 1.229 | -0.1075 | -0.06320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4033 | 1.463 | -5.606 | 3.135 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1416 | 0.07801 | -0.9461 | -2.867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.063 | 1.817 | 1.008 | -2.075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 474.85832 | 1.003 | -1.150 | -0.9245 | -0.9383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.005 | -0.9775 | 0.03184 | -0.7513 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8823 | -0.7996 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5032 | -0.8605 | -1.061 | -0.2334 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.85832 | 91.32 | -5.350 | -0.9026 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4162 | 1.206 | 0.06204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7875 | 0.7089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.614 | 0.9665 | 0.7015 | 1.983 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.85832</span> | 91.32 | 0.004746 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009875 | 0.6026 | 1.206 | 0.06204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7875 | 0.7089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.614 | 0.9665 | 0.7015 | 1.983 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.689 | 1.242 | 0.1265 | -0.09001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3949 | 1.405 | -5.495 | 3.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1166 | 0.02645 | -0.9105 | -0.7126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.952 | 1.861 | 0.8779 | -2.102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 474.83791 | 1.001 | -1.151 | -0.9246 | -0.9382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9784 | 0.03545 | -0.7535 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7596 | -0.8823 | -0.7990 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5052 | -0.8617 | -1.062 | -0.2320 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.83791 | 91.10 | -5.351 | -0.9027 | -2.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4158 | 1.208 | 0.06198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7879 | 0.7094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.612 | 0.9653 | 0.7010 | 1.985 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.83791</span> | 91.10 | 0.004742 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009872 | 0.6025 | 1.208 | 0.06198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7879 | 0.7094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.612 | 0.9653 | 0.7010 | 1.985 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.77 | 1.225 | -0.1616 | -0.05944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4032 | 1.455 | -5.461 | 3.071 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1419 | 0.08593 | -0.9091 | -0.8855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.951 | 1.791 | 0.9091 | -2.062 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 474.78971 | 1.004 | -1.152 | -0.9246 | -0.9381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9794 | 0.03911 | -0.7559 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7984 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5068 | -0.8614 | -1.062 | -0.2307 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.78971 | 91.33 | -5.352 | -0.9026 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.618 | 0.4153 | 1.209 | 0.06191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7883 | 0.7086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.610 | 0.9656 | 0.7006 | 1.986 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.78971</span> | 91.33 | 0.004738 | 0.2885 | 0.1107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009869 | 0.6024 | 1.209 | 0.06191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7883 | 0.7086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.610 | 0.9656 | 0.7006 | 1.986 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.398 | 1.237 | 0.1402 | -0.09195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3940 | 1.388 | -4.885 | 3.322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1374 | 0.01792 | -0.6865 | -2.709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.810 | 1.778 | 0.8100 | -2.095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 474.76763 | 1.001 | -1.153 | -0.9247 | -0.9380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9804 | 0.04256 | -0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7979 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5086 | -0.8621 | -1.063 | -0.2293 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.76763 | 91.11 | -5.353 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4149 | 1.211 | 0.06184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7887 | 0.7097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.608 | 0.9650 | 0.7001 | 1.988 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.76763</span> | 91.11 | 0.004734 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009867 | 0.6023 | 1.211 | 0.06184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7887 | 0.7097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.608 | 0.9650 | 0.7001 | 1.988 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.92 | 1.222 | -0.1466 | -0.06186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4014 | 1.433 | -4.989 | 3.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1326 | 0.08284 | -0.6789 | -2.803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.814 | 1.775 | 0.8327 | -2.053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 474.71973 | 1.004 | -1.154 | -0.9246 | -0.9379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | -0.9816 | 0.04617 | -0.7611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8824 | -0.7975 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5100 | -0.8614 | -1.064 | -0.2281 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.71973 | 91.32 | -5.354 | -0.9026 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4143 | 1.212 | 0.06176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7890 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.606 | 0.9656 | 0.6996 | 1.990 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.71973</span> | 91.32 | 0.004729 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009863 | 0.6021 | 1.212 | 0.06176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7890 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.606 | 0.9656 | 0.6996 | 1.990 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.021 | 1.236 | 0.1299 | -0.09158 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3929 | 1.368 | -4.925 | 3.331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07142 | 0.08893 | -0.6522 | -2.634 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.639 | 1.780 | 0.7273 | -2.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 474.70040 | 1.001 | -1.155 | -0.9247 | -0.9379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9826 | 0.04954 | -0.7634 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8825 | -0.7971 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5117 | -0.8624 | -1.064 | -0.2267 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.7004 | 91.10 | -5.355 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.619 | 0.4139 | 1.214 | 0.06169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7893 | 0.7114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.604 | 0.9647 | 0.6992 | 1.991 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.7004</span> | 91.10 | 0.004724 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009861 | 0.6020 | 1.214 | 0.06169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7893 | 0.7114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.604 | 0.9647 | 0.6992 | 1.991 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.76 | 1.220 | -0.1617 | -0.06091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4007 | 1.415 | -5.116 | 3.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1298 | 0.07714 | -0.6701 | -2.700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.670 | 1.748 | 0.7590 | -2.043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 474.65116 | 1.003 | -1.156 | -0.9246 | -0.9378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9837 | 0.05321 | -0.7662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8825 | -0.7967 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5130 | -0.8617 | -1.065 | -0.2255 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.65116 | 91.32 | -5.356 | -0.9026 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4134 | 1.215 | 0.06161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7896 | 0.7116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.603 | 0.9653 | 0.6987 | 1.993 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.65116</span> | 91.32 | 0.004720 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009857 | 0.6019 | 1.215 | 0.06161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7896 | 0.7116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.603 | 0.9653 | 0.6987 | 1.993 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.462 | 1.239 | 0.1107 | -0.09136 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3915 | 1.348 | -5.441 | 3.268 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1113 | 0.02510 | -0.6252 | -2.485 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.647 | 1.796 | 0.6587 | -2.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 474.63065 | 1.001 | -1.157 | -0.9247 | -0.9377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.007 | -0.9846 | 0.05678 | -0.7683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7597 | -0.8825 | -0.7963 | -1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5148 | -0.8629 | -1.065 | -0.2241 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.63065 | 91.11 | -5.357 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4129 | 1.217 | 0.06155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7899 | 0.7131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.600 | 0.9642 | 0.6984 | 1.994 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.63065</span> | 91.11 | 0.004716 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009855 | 0.6018 | 1.217 | 0.06155 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7899 | 0.7131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.600 | 0.9642 | 0.6984 | 1.994 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -14.93 | 1.220 | -0.1531 | -0.06288 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3983 | 1.394 | -5.436 | 3.113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1458 | 0.07621 | -0.8397 | -0.6848 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.501 | 1.690 | 0.6891 | -2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 474.58497 | 1.004 | -1.158 | -0.9246 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9857 | 0.06060 | -0.7708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8826 | -0.7958 | -1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5162 | -0.8624 | -1.065 | -0.2230 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.58497 | 91.34 | -5.358 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4125 | 1.218 | 0.06148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7902 | 0.7126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.599 | 0.9647 | 0.6980 | 1.996 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.58497</span> | 91.34 | 0.004711 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009852 | 0.6017 | 1.218 | 0.06148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7902 | 0.7126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.599 | 0.9647 | 0.6980 | 1.996 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.248 | 1.234 | 0.1371 | -0.09456 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3896 | 1.328 | -5.011 | 3.180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1110 | 0.004022 | -0.8103 | -0.4964 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.349 | 1.713 | 0.5705 | -2.061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 474.55760 | 1.002 | -1.159 | -0.9247 | -0.9376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9867 | 0.06444 | -0.7734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7598 | -0.8826 | -0.7952 | -1.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5178 | -0.8626 | -1.066 | -0.2215 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.5576 | 91.15 | -5.359 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.620 | 0.4120 | 1.220 | 0.06140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7907 | 0.7122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.597 | 0.9645 | 0.6977 | 1.998 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.5576</span> | 91.15 | 0.004706 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009849 | 0.6016 | 1.220 | 0.06140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8777 | 0.05824 | 0.7907 | 0.7122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.597 | 0.9645 | 0.6977 | 1.998 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.86 | 1.219 | -0.1003 | -0.07615 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3954 | 1.369 | -4.929 | 3.171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1229 | 0.06540 | -0.8183 | -0.7141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.360 | 1.696 | 0.6359 | -2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 474.51619 | 1.004 | -1.160 | -0.9246 | -0.9375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.008 | -0.9878 | 0.06816 | -0.7761 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8826 | -0.7946 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5193 | -0.8622 | -1.066 | -0.2202 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.51619 | 91.33 | -5.360 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4115 | 1.221 | 0.06132 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7911 | 0.7113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.595 | 0.9648 | 0.6972 | 1.999 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.51619</span> | 91.33 | 0.004702 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009846 | 0.6014 | 1.221 | 0.06132 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7911 | 0.7113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.595 | 0.9648 | 0.6972 | 1.999 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.413 | 1.225 | 0.1371 | -0.09620 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3880 | 1.314 | -5.554 | 3.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07604 | 0.008867 | -0.7931 | -0.6282 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.148 | 1.715 | 0.5273 | -2.052 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 474.48673 | 1.002 | -1.161 | -0.9247 | -0.9374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9889 | 0.07224 | -0.7786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7599 | -0.8826 | -0.7941 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5208 | -0.8625 | -1.067 | -0.2188 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.48673 | 91.17 | -5.361 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4110 | 1.223 | 0.06125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7915 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.593 | 0.9645 | 0.6969 | 2.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.48673</span> | 91.17 | 0.004697 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009843 | 0.6013 | 1.223 | 0.06125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7915 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.593 | 0.9645 | 0.6969 | 2.001 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.51 | 1.211 | -0.06554 | -0.07429 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3932 | 1.350 | -4.456 | 3.182 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08901 | 0.05354 | -0.5957 | -2.739 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.160 | 1.696 | 0.5687 | -2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 474.45218 | 1.004 | -1.162 | -0.9246 | -0.9373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9900 | 0.07590 | -0.7814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8826 | -0.7937 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5220 | -0.8620 | -1.067 | -0.2177 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.45218 | 91.40 | -5.362 | -0.9027 | -2.200 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.621 | 0.4105 | 1.224 | 0.06117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7918 | 0.7111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.592 | 0.9650 | 0.6965 | 2.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.45218</span> | 91.40 | 0.004692 | 0.2885 | 0.1108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009840 | 0.6012 | 1.224 | 0.06117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05823 | 0.7918 | 0.7111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.592 | 0.9650 | 0.6965 | 2.002 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.724 | 1.224 | 0.2009 | -0.1069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3834 | 1.279 | -5.556 | 3.324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1101 | -0.01912 | -0.5638 | -2.553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.043 | 1.731 | 0.4140 | -2.044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 474.41257 | 1.003 | -1.163 | -0.9246 | -0.9371 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.009 | -0.9913 | 0.07979 | -0.7844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7935 | -1.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5231 | -0.8612 | -1.068 | -0.2167 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.41257 | 91.25 | -5.363 | -0.9026 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4099 | 1.226 | 0.06108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7919 | 0.7118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.591 | 0.9658 | 0.6961 | 2.004 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.41257</span> | 91.25 | 0.004687 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009836 | 0.6011 | 1.226 | 0.06108 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7919 | 0.7118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.591 | 0.9658 | 0.6961 | 2.004 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.208 | 1.213 | 0.03978 | -0.08693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3876 | 1.303 | -5.023 | 3.218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1347 | 0.02311 | -0.7771 | -0.6556 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.056 | 1.822 | 0.4520 | -2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 474.39271 | 1.005 | -1.164 | -0.9246 | -0.9371 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9922 | 0.08348 | -0.7867 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7600 | -0.8825 | -0.7930 | -1.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5246 | -0.8625 | -1.068 | -0.2152 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.39271 | 91.47 | -5.364 | -0.9027 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4094 | 1.228 | 0.06101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7923 | 0.7123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.589 | 0.9645 | 0.6958 | 2.005 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.39271</span> | 91.47 | 0.004683 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009833 | 0.6010 | 1.228 | 0.06101 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7923 | 0.7123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.589 | 0.9645 | 0.6958 | 2.005 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.86 | 1.227 | 0.2807 | -0.1163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3793 | 1.243 | -5.494 | 3.329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09368 | 0.01293 | -0.5149 | -2.407 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.979 | 1.686 | 0.3308 | -2.044 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 474.34538 | 1.003 | -1.165 | -0.9247 | -0.9369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9934 | 0.08718 | -0.7897 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7926 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5258 | -0.8620 | -1.068 | -0.2141 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.34538 | 91.27 | -5.365 | -0.9027 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.622 | 0.4089 | 1.229 | 0.06093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7926 | 0.7117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.587 | 0.9650 | 0.6954 | 2.007 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.34538</span> | 91.27 | 0.004677 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009830 | 0.6008 | 1.229 | 0.06093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7926 | 0.7117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.587 | 0.9650 | 0.6954 | 2.007 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.345 | 1.210 | 0.04189 | -0.08986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3855 | 1.284 | -5.145 | 3.218 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1284 | 0.01309 | -0.7466 | -0.6536 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.964 | 1.743 | 0.3816 | -2.008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 474.31834 | 1.005 | -1.166 | -0.9247 | -0.9369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9944 | 0.09109 | -0.7921 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7600 | -0.8825 | -0.7920 | -1.085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5273 | -0.8633 | -1.069 | -0.2126 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.31834 | 91.43 | -5.366 | -0.9027 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4085 | 1.231 | 0.06086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7930 | 0.7121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.586 | 0.9638 | 0.6952 | 2.008 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.31834</span> | 91.43 | 0.004673 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009827 | 0.6007 | 1.231 | 0.06086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8776 | 0.05824 | 0.7930 | 0.7121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.586 | 0.9638 | 0.6952 | 2.008 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.13 | 1.219 | 0.2312 | -0.1125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3787 | 1.238 | -5.317 | 3.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08361 | -0.02599 | -0.7000 | -0.4940 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.837 | 1.637 | 0.3211 | -2.028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 474.27833 | 1.003 | -1.167 | -0.9247 | -0.9368 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.010 | -0.9955 | 0.09487 | -0.7949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7915 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5286 | -0.8630 | -1.069 | -0.2114 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.27833 | 91.25 | -5.367 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4080 | 1.232 | 0.06078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7934 | 0.7111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9640 | 0.6948 | 2.010 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.27833</span> | 91.25 | 0.004668 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009824 | 0.6006 | 1.232 | 0.06078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7934 | 0.7111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.584 | 0.9640 | 0.6948 | 2.010 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.145 | 1.202 | 0.02355 | -0.08919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3842 | 1.275 | -5.102 | 3.189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1071 | 0.01700 | -0.7283 | -0.7209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.776 | 1.686 | 0.3249 | -1.982 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 474.25305 | 1.005 | -1.168 | -0.9247 | -0.9367 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9965 | 0.09878 | -0.7975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7601 | -0.8825 | -0.7909 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5300 | -0.8636 | -1.069 | -0.2100 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.25305 | 91.44 | -5.368 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.623 | 0.4075 | 1.234 | 0.06070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7938 | 0.7109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.583 | 0.9635 | 0.6946 | 2.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.25305</span> | 91.44 | 0.004663 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009821 | 0.6005 | 1.234 | 0.06070 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7938 | 0.7109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.583 | 0.9635 | 0.6946 | 2.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.11 | 1.213 | 0.2527 | -0.1161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3767 | 1.219 | -5.003 | 3.213 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09270 | -0.04298 | -0.4814 | -2.533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.730 | 1.613 | 0.2495 | -2.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 474.21254 | 1.003 | -1.169 | -0.9248 | -0.9365 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9977 | 0.1025 | -0.8005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8824 | -0.7906 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5311 | -0.8630 | -1.070 | -0.2089 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.21254 | 91.24 | -5.369 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4069 | 1.236 | 0.06062 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7941 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.581 | 0.9641 | 0.6942 | 2.013 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.21254</span> | 91.24 | 0.004658 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009817 | 0.6003 | 1.236 | 0.06062 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7941 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.581 | 0.9641 | 0.6942 | 2.013 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.267 | 1.195 | 0.01760 | -0.08987 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3825 | 1.260 | -5.272 | 3.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1336 | 0.009843 | -0.5186 | -2.706 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.727 | 1.652 | 0.2904 | -1.976 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 474.18171 | 1.004 | -1.170 | -0.9247 | -0.9364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.011 | -0.9989 | 0.1065 | -0.8033 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8823 | -0.7904 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5322 | -0.8627 | -1.070 | -0.2078 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.18171 | 91.41 | -5.370 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4064 | 1.237 | 0.06054 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7942 | 0.7112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.580 | 0.9644 | 0.6939 | 2.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.18171</span> | 91.41 | 0.004653 | 0.2885 | 0.1109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009814 | 0.6002 | 1.237 | 0.06054 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05824 | 0.7942 | 0.7112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.580 | 0.9644 | 0.6939 | 2.014 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.716 | 1.206 | 0.2113 | -0.1128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3755 | 1.207 | -5.399 | 3.226 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09670 | -0.03459 | -0.6713 | -0.5638 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | 1.687 | 0.2005 | -1.998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 474.14509 | 1.003 | -1.171 | -0.9248 | -0.9363 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.000 | 0.1105 | -0.8061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7602 | -0.8822 | -0.7900 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5333 | -0.8621 | -1.071 | -0.2068 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.14509 | 91.25 | -5.371 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.624 | 0.4059 | 1.239 | 0.06045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05825 | 0.7945 | 0.7106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.579 | 0.9649 | 0.6936 | 2.015 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.14509</span> | 91.25 | 0.004648 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009811 | 0.6001 | 1.239 | 0.06045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8775 | 0.05825 | 0.7945 | 0.7106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.579 | 0.9649 | 0.6936 | 2.015 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.280 | 1.192 | 0.02321 | -0.09129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3799 | 1.239 | -5.339 | 3.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1074 | 0.06181 | -0.4875 | -2.680 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.648 | 1.743 | 0.2195 | -1.955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 474.11542 | 1.005 | -1.172 | -0.9248 | -0.9361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.001 | 0.1146 | -0.8089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7603 | -0.8821 | -0.7897 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5344 | -0.8621 | -1.071 | -0.2057 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.11542 | 91.42 | -5.372 | -0.9028 | -2.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4054 | 1.241 | 0.06037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7947 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.577 | 0.9649 | 0.6934 | 2.017 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.11542</span> | 91.42 | 0.004643 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009807 | 0.6000 | 1.241 | 0.06037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7947 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.577 | 0.9649 | 0.6934 | 2.017 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.52 | 1.202 | 0.2258 | -0.1162 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3725 | 1.186 | -5.381 | 3.222 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1104 | -0.04157 | -0.6550 | -0.5841 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.505 | 1.701 | 0.1753 | -1.993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 474.07794 | 1.003 | -1.173 | -0.9248 | -0.9360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.012 | -1.002 | 0.1187 | -0.8117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7604 | -0.8821 | -0.7895 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5355 | -0.8615 | -1.071 | -0.2048 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.07794 | 91.25 | -5.373 | -0.9028 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4048 | 1.242 | 0.06029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7949 | 0.7104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.576 | 0.9655 | 0.6932 | 2.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.07794</span> | 91.25 | 0.004638 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009804 | 0.5999 | 1.242 | 0.06029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7949 | 0.7104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.576 | 0.9655 | 0.6932 | 2.018 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.801 | 1.188 | 0.03689 | -0.09236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3785 | 1.221 | -5.368 | 3.104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1066 | 0.003449 | -0.6711 | -0.7398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 1.803 | 0.1884 | -1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 474.04951 | 1.005 | -1.175 | -0.9248 | -0.9359 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.003 | 0.1228 | -0.8144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7604 | -0.8820 | -0.7890 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5367 | -0.8618 | -1.071 | -0.2036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.04951 | 91.43 | -5.375 | -0.9028 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.625 | 0.4044 | 1.244 | 0.06021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7952 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.575 | 0.9652 | 0.6930 | 2.019 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.04951</span> | 91.43 | 0.004633 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009801 | 0.5997 | 1.244 | 0.06021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8774 | 0.05825 | 0.7952 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.575 | 0.9652 | 0.6930 | 2.019 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.86 | 1.196 | 0.2377 | -0.1190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3700 | 1.169 | -5.399 | 3.259 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09645 | -0.03914 | -0.4400 | -2.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.421 | 1.705 | 0.1351 | -1.978 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 474.01246 | 1.003 | -1.176 | -0.9249 | -0.9357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.004 | 0.1268 | -0.8173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7606 | -0.8819 | -0.7888 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5377 | -0.8613 | -1.072 | -0.2028 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.01246 | 91.25 | -5.376 | -0.9029 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4039 | 1.246 | 0.06013 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05825 | 0.7954 | 0.7098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.573 | 0.9657 | 0.6927 | 2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.01246</span> | 91.25 | 0.004628 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009798 | 0.5996 | 1.246 | 0.06013 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05825 | 0.7954 | 0.7098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.573 | 0.9657 | 0.6927 | 2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.724 | 1.179 | 0.03043 | -0.09493 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3750 | 1.206 | -5.283 | 3.092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09863 | -0.01543 | -0.6573 | -0.7980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.377 | 1.778 | 0.1578 | -1.944 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 473.98155 | 1.005 | -1.177 | -0.9249 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.013 | -1.005 | 0.1310 | -0.8202 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7607 | -0.8818 | -0.7885 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5387 | -0.8611 | -1.072 | -0.2018 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.98155 | 91.42 | -5.377 | -0.9029 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4034 | 1.247 | 0.06004 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05826 | 0.7956 | 0.7095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9659 | 0.6925 | 2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.98155</span> | 91.42 | 0.004623 | 0.2885 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009794 | 0.5995 | 1.247 | 0.06004 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8773 | 0.05826 | 0.7956 | 0.7095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.572 | 0.9659 | 0.6925 | 2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.125 | 1.189 | 0.2215 | -0.1183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3680 | 1.157 | -5.346 | 3.214 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06695 | -0.05805 | -0.6245 | -0.6678 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.365 | 1.770 | 0.07348 | -1.960 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 473.94647 | 1.003 | -1.178 | -0.9250 | -0.9354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.007 | 0.1350 | -0.8231 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7608 | -0.8817 | -0.7881 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5397 | -0.8608 | -1.072 | -0.2009 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.94647 | 91.26 | -5.378 | -0.9030 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.626 | 0.4029 | 1.249 | 0.05996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7959 | 0.7086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.571 | 0.9661 | 0.6923 | 2.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.94647</span> | 91.26 | 0.004618 | 0.2884 | 0.1110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009791 | 0.5994 | 1.249 | 0.05996 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7959 | 0.7086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.571 | 0.9661 | 0.6923 | 2.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.271 | 1.174 | 0.04603 | -0.09766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3725 | 1.188 | -5.320 | 3.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09768 | -0.01918 | -0.6378 | -0.8469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.360 | 1.825 | 0.08453 | -1.920 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 473.91708 | 1.005 | -1.179 | -0.9250 | -0.9353 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.008 | 0.1391 | -0.8259 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7609 | -0.8816 | -0.7877 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5408 | -0.8610 | -1.072 | -0.1999 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.91708 | 91.43 | -5.379 | -0.9030 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4024 | 1.251 | 0.05988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7962 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.570 | 0.9660 | 0.6921 | 2.024 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.91708</span> | 91.43 | 0.004613 | 0.2884 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009788 | 0.5993 | 1.251 | 0.05988 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8772 | 0.05826 | 0.7962 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.570 | 0.9660 | 0.6921 | 2.024 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.919 | 1.183 | 0.2388 | -0.1221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3649 | 1.138 | -5.295 | 3.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05759 | -0.06746 | -0.6018 | -0.7458 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.218 | 1.797 | 0.02666 | -1.950 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 473.88166 | 1.003 | -1.180 | -0.9251 | -0.9351 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.014 | -1.009 | 0.1432 | -0.8289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7611 | -0.8814 | -0.7874 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5418 | -0.8607 | -1.072 | -0.1991 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.88166 | 91.26 | -5.380 | -0.9031 | -2.198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4019 | 1.252 | 0.05979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7964 | 0.7073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 0.9662 | 0.6919 | 2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.88166</span> | 91.26 | 0.004608 | 0.2884 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009785 | 0.5991 | 1.252 | 0.05979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7964 | 0.7073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.568 | 0.9662 | 0.6919 | 2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.370 | 1.167 | 0.05346 | -0.09978 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3701 | 1.174 | -5.172 | 3.105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07011 | -0.02516 | -0.4239 | -2.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.187 | 1.854 | 0.07395 | -1.907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 473.85215 | 1.005 | -1.181 | -0.9251 | -0.9350 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.010 | 0.1472 | -0.8318 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7612 | -0.8813 | -0.7872 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5427 | -0.8608 | -1.073 | -0.1983 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.85215 | 91.44 | -5.381 | -0.9031 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.627 | 0.4014 | 1.254 | 0.05971 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7965 | 0.7078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9662 | 0.6918 | 2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.85215</span> | 91.44 | 0.004603 | 0.2884 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009781 | 0.5990 | 1.254 | 0.05971 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8771 | 0.05827 | 0.7965 | 0.7078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9662 | 0.6918 | 2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.42 | 1.179 | 0.2474 | -0.1240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3627 | 1.120 | -5.345 | 3.221 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07960 | -0.04998 | -0.3836 | -2.755 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.094 | 1.797 | -0.01014 | -1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 473.81514 | 1.003 | -1.182 | -0.9251 | -0.9348 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.011 | 0.1513 | -0.8349 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7614 | -0.8810 | -0.7873 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5432 | -0.8601 | -1.073 | -0.1979 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.81514 | 91.27 | -5.382 | -0.9031 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.4008 | 1.256 | 0.05962 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05828 | 0.7964 | 0.7084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9669 | 0.6916 | 2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.81514</span> | 91.27 | 0.004598 | 0.2884 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009778 | 0.5989 | 1.256 | 0.05962 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05828 | 0.7964 | 0.7084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.567 | 0.9669 | 0.6916 | 2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.811 | 1.166 | 0.05684 | -0.1019 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3663 | 1.150 | -5.276 | 3.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06818 | -0.03474 | -0.4125 | -2.836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.158 | 1.851 | 0.03258 | -1.914 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 473.78884 | 1.005 | -1.183 | -0.9252 | -0.9346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.015 | -1.012 | 0.1554 | -0.8377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7615 | -0.8808 | -0.7873 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | -0.8602 | -1.073 | -0.1971 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.78884 | 91.46 | -5.383 | -0.9031 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.4003 | 1.257 | 0.05954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05829 | 0.7965 | 0.7095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.566 | 0.9667 | 0.6915 | 2.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.78884</span> | 91.46 | 0.004593 | 0.2884 | 0.1111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009775 | 0.5988 | 1.257 | 0.05954 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8770 | 0.05829 | 0.7965 | 0.7095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.566 | 0.9667 | 0.6915 | 2.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.26 | 1.178 | 0.2628 | -0.1282 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3579 | 1.094 | -5.180 | 3.234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08932 | -0.09780 | -0.5652 | -0.6340 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.031 | 1.841 | -0.06209 | -1.938 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 473.75065 | 1.003 | -1.184 | -0.9252 | -0.9344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.013 | 0.1594 | -0.8407 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7617 | -0.8806 | -0.7872 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5446 | -0.8597 | -1.073 | -0.1966 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.75065 | 91.27 | -5.384 | -0.9032 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.628 | 0.3998 | 1.259 | 0.05945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8769 | 0.05829 | 0.7965 | 0.7092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9672 | 0.6914 | 2.028 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.75065</span> | 91.27 | 0.004588 | 0.2884 | 0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009772 | 0.5986 | 1.259 | 0.05945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8769 | 0.05829 | 0.7965 | 0.7092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.565 | 0.9672 | 0.6914 | 2.028 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.250 | 1.164 | 0.05078 | -0.1019 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3635 | 1.132 | -5.308 | 3.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09569 | -0.05602 | -0.5891 | -0.8121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.074 | 1.883 | 0.002586 | -1.906 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 473.72028 | 1.005 | -1.185 | -0.9252 | -0.9343 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.014 | 0.1635 | -0.8437 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7618 | -0.8804 | -0.7870 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5455 | -0.8599 | -1.073 | -0.1958 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.72028 | 91.43 | -5.385 | -0.9032 | -2.197 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3993 | 1.261 | 0.05936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05830 | 0.7967 | 0.7088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.564 | 0.9671 | 0.6912 | 2.029 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.72028</span> | 91.43 | 0.004583 | 0.2884 | 0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009768 | 0.5985 | 1.261 | 0.05936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05830 | 0.7967 | 0.7088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.564 | 0.9671 | 0.6912 | 2.029 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.975 | 1.171 | 0.2290 | -0.1246 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3563 | 1.085 | -5.320 | 3.173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08707 | -0.1016 | -0.5561 | -0.7117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9536 | 1.850 | -0.07963 | -1.922 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 473.68600 | 1.003 | -1.186 | -0.9253 | -0.9341 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.016 | -1.015 | 0.1676 | -0.8467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7620 | -0.8801 | -0.7868 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5463 | -0.8596 | -1.073 | -0.1952 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.686 | 91.28 | -5.386 | -0.9033 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3989 | 1.263 | 0.05928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05831 | 0.7968 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 0.9673 | 0.6911 | 2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.686</span> | 91.28 | 0.004578 | 0.2884 | 0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009765 | 0.5984 | 1.263 | 0.05928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8768 | 0.05831 | 0.7968 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.563 | 0.9673 | 0.6911 | 2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.608 | 1.155 | 0.05506 | -0.1036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3607 | 1.118 | -5.212 | 3.031 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08611 | -0.04336 | -0.3798 | -2.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.093 | 1.880 | -0.02731 | -1.896 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 473.65599 | 1.005 | -1.188 | -0.9253 | -0.9339 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -1.016 | 0.1718 | -0.8497 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7621 | -0.8799 | -0.7868 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5471 | -0.8595 | -1.074 | -0.1946 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.65599 | 91.44 | -5.388 | -0.9033 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.629 | 0.3984 | 1.264 | 0.05919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8767 | 0.05831 | 0.7968 | 0.7087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9674 | 0.6910 | 2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.65599</span> | 91.44 | 0.004573 | 0.2884 | 0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009762 | 0.5983 | 1.264 | 0.05919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8767 | 0.05831 | 0.7968 | 0.7087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9674 | 0.6910 | 2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.720 | 1.170 | 0.2444 | -0.1229 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3557 | 1.067 | -5.275 | 3.173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07850 | -0.1042 | -0.5348 | -0.6844 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9479 | 1.915 | -0.1018 | -1.917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 473.62083 | 1.003 | -1.189 | -0.9254 | -0.9337 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.017 | -1.017 | 0.1759 | -0.8528 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7623 | -0.8795 | -0.7869 | -1.089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5477 | -0.8591 | -1.074 | -0.1942 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.62083 | 91.28 | -5.389 | -0.9033 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3979 | 1.266 | 0.05910 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05832 | 0.7968 | 0.7085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9678 | 0.6909 | 2.031 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.62083</span> | 91.28 | 0.004568 | 0.2884 | 0.1112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009758 | 0.5982 | 1.266 | 0.05910 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05832 | 0.7968 | 0.7085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.562 | 0.9678 | 0.6909 | 2.031 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.323 | 1.153 | 0.05982 | -0.1053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3572 | 1.098 | -4.702 | 3.058 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1117 | -0.04281 | -0.5573 | -0.7999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.039 | 1.912 | -0.05974 | -1.890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 473.59326 | 1.005 | -1.190 | -0.9254 | -0.9335 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.019 | 0.1798 | -0.8560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7624 | -0.8793 | -0.7867 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5486 | -0.8595 | -1.074 | -0.1934 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.59326 | 91.46 | -5.390 | -0.9034 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3974 | 1.268 | 0.05901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05833 | 0.7969 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9674 | 0.6908 | 2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.59326</span> | 91.46 | 0.004562 | 0.2884 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009755 | 0.5981 | 1.268 | 0.05901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8766 | 0.05833 | 0.7969 | 0.7081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9674 | 0.6908 | 2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.25 | 1.162 | 0.2586 | -0.1299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3499 | 1.048 | -5.229 | 3.126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05642 | -0.09930 | -0.3252 | -2.718 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8202 | 1.876 | -0.1477 | -1.910 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 473.55541 | 1.003 | -1.191 | -0.9255 | -0.9333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.020 | 0.1836 | -0.8595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8789 | -0.7868 | -1.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5492 | -0.8592 | -1.074 | -0.1932 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.55541 | 91.31 | -5.391 | -0.9034 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.630 | 0.3968 | 1.269 | 0.05891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7968 | 0.7080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9677 | 0.6906 | 2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.55541</span> | 91.31 | 0.004557 | 0.2883 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009751 | 0.5979 | 1.269 | 0.05891 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7968 | 0.7080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.560 | 0.9677 | 0.6906 | 2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.062 | 1.149 | 0.09224 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3525 | 1.070 | -5.098 | 2.994 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1095 | -0.04877 | -0.3504 | -2.828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8255 | 1.898 | -0.1147 | -1.889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 473.53708 | 1.006 | -1.192 | -0.9256 | -0.9332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.021 | 0.1873 | -0.8616 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7625 | -0.8789 | -0.7866 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5498 | -0.8606 | -1.074 | -0.1918 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.53708 | 91.52 | -5.392 | -0.9035 | -2.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3964 | 1.271 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7970 | 0.7099 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9664 | 0.6907 | 2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.53708</span> | 91.52 | 0.004553 | 0.2883 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009749 | 0.5978 | 1.271 | 0.05884 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05834 | 0.7970 | 0.7099 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9664 | 0.6907 | 2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.25 | 1.165 | 0.3077 | -0.1378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3448 | 1.019 | -5.264 | 3.150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.09278 | -0.1366 | -0.2969 | -2.557 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7485 | 1.781 | -0.1828 | -1.909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 473.49312 | 1.003 | -1.193 | -0.9256 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.018 | -1.022 | 0.1912 | -0.8647 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8785 | -0.7869 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5501 | -0.8598 | -1.074 | -0.1918 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.49312 | 91.32 | -5.393 | -0.9035 | -2.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3959 | 1.272 | 0.05875 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7967 | 0.7106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9671 | 0.6906 | 2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.49312</span> | 91.32 | 0.004547 | 0.2883 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009745 | 0.5977 | 1.272 | 0.05875 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7967 | 0.7106 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.559 | 0.9671 | 0.6906 | 2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.793 | 1.150 | 0.08391 | -0.1095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3500 | 1.057 | -5.154 | 2.847 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07414 | -0.06025 | -0.5244 | -0.6779 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8291 | 1.867 | -0.1201 | -1.880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 473.47390 | 1.006 | -1.194 | -0.9256 | -0.9329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.022 | 0.1953 | -0.8670 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7626 | -0.8785 | -0.7865 | -1.086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5507 | -0.8613 | -1.074 | -0.1903 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.4739 | 91.52 | -5.394 | -0.9036 | -2.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.631 | 0.3955 | 1.274 | 0.05869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7970 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9657 | 0.6907 | 2.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4739</span> | 91.52 | 0.004543 | 0.2883 | 0.1113 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009743 | 0.5976 | 1.274 | 0.05869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8765 | 0.05835 | 0.7970 | 0.7110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.558 | 0.9657 | 0.6907 | 2.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.82 | 1.163 | 0.3026 | -0.1376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3423 | 1.007 | -4.821 | 3.176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06207 | -0.1161 | -0.4712 | -0.4774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7015 | 1.725 | -0.1877 | -1.896 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 473.43080 | 1.003 | -1.195 | -0.9257 | -0.9326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.024 | 0.1991 | -0.8700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7628 | -0.8781 | -0.7866 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5513 | -0.8608 | -1.074 | -0.1899 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.4308 | 91.31 | -5.395 | -0.9036 | -2.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3950 | 1.276 | 0.05860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05836 | 0.7970 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.557 | 0.9662 | 0.6906 | 2.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4308</span> | 91.31 | 0.004538 | 0.2883 | 0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009739 | 0.5975 | 1.276 | 0.05860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05836 | 0.7970 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.557 | 0.9662 | 0.6906 | 2.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.611 | 1.145 | 0.07564 | -0.1091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3478 | 1.048 | -5.196 | 2.853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07176 | -0.06153 | -0.5100 | -0.6862 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7701 | 1.783 | -0.1204 | -1.866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 473.40390 | 1.005 | -1.196 | -0.9258 | -0.9324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.019 | -1.025 | 0.2034 | -0.8728 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7629 | -0.8779 | -0.7864 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5520 | -0.8612 | -1.074 | -0.1890 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.4039 | 91.48 | -5.396 | -0.9037 | -2.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3946 | 1.277 | 0.05852 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05837 | 0.7971 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9658 | 0.6906 | 2.037 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.4039</span> | 91.48 | 0.004533 | 0.2883 | 0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009736 | 0.5974 | 1.277 | 0.05852 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8764 | 0.05837 | 0.7971 | 0.7105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9658 | 0.6906 | 2.037 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.82 | 1.154 | 0.2542 | -0.1321 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3410 | 1.002 | -5.150 | 3.097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04820 | -0.1059 | -0.4698 | -0.5387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 1.733 | -0.1906 | -1.879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 473.36686 | 1.003 | -1.198 | -0.9258 | -0.9322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.026 | 0.2076 | -0.8758 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7631 | -0.8776 | -0.7865 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5525 | -0.8606 | -1.074 | -0.1886 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.36686 | 91.32 | -5.398 | -0.9037 | -2.195 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.632 | 0.3941 | 1.279 | 0.05843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7970 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9664 | 0.6905 | 2.038 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.36686</span> | 91.32 | 0.004527 | 0.2883 | 0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009733 | 0.5973 | 1.279 | 0.05843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7970 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.556 | 0.9664 | 0.6905 | 2.038 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.686 | 1.139 | 0.08028 | -0.1103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3450 | 1.034 | -5.059 | 2.983 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07022 | -0.06541 | -0.4954 | -0.7148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6839 | 1.782 | -0.1353 | -1.853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 473.34117 | 1.005 | -1.199 | -0.9259 | -0.9321 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.027 | 0.2118 | -0.8787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7632 | -0.8774 | -0.7864 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5531 | -0.8611 | -1.074 | -0.1877 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.34117 | 91.49 | -5.399 | -0.9038 | -2.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3936 | 1.281 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7971 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9659 | 0.6904 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.34117</span> | 91.49 | 0.004522 | 0.2883 | 0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009730 | 0.5972 | 1.281 | 0.05835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8763 | 0.05838 | 0.7971 | 0.7100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9659 | 0.6904 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.62 | 1.149 | 0.2679 | -0.1346 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3379 | 0.9875 | -5.147 | 2.965 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07400 | -0.1145 | -0.4542 | -0.5455 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6283 | 1.734 | -0.2097 | -1.869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 473.30326 | 1.004 | -1.200 | -0.9259 | -0.9318 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.020 | -1.028 | 0.2159 | -0.8818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7634 | -0.8771 | -0.7865 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5535 | -0.8604 | -1.074 | -0.1874 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.30326 | 91.32 | -5.400 | -0.9038 | -2.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3932 | 1.283 | 0.05826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05839 | 0.7970 | 0.7096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9665 | 0.6903 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.30326</span> | 91.32 | 0.004517 | 0.2883 | 0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009726 | 0.5970 | 1.283 | 0.05826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05839 | 0.7970 | 0.7096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.555 | 0.9665 | 0.6903 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.609 | 1.134 | 0.08636 | -0.1114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3423 | 1.018 | -5.228 | 2.880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1079 | -0.06580 | -0.2896 | -2.686 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6917 | 1.801 | -0.1599 | -1.842 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 473.27616 | 1.005 | -1.201 | -0.9260 | -0.9316 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.029 | 0.2202 | -0.8845 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7634 | -0.8768 | -0.7866 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5540 | -0.8607 | -1.074 | -0.1867 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.27616 | 91.48 | -5.401 | -0.9039 | -2.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.633 | 0.3927 | 1.284 | 0.05818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05840 | 0.7970 | 0.7107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9663 | 0.6904 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.27616</span> | 91.48 | 0.004512 | 0.2883 | 0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009723 | 0.5969 | 1.284 | 0.05818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8762 | 0.05840 | 0.7970 | 0.7107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9663 | 0.6904 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.44 | 1.145 | 0.2516 | -0.1333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3351 | 0.9744 | -4.753 | 3.090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05028 | -0.1148 | -0.4450 | -0.5198 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5573 | 1.743 | -0.2240 | -1.858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 473.24283 | 1.003 | -1.202 | -0.9260 | -0.9314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.030 | 0.2240 | -0.8877 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7636 | -0.8764 | -0.7870 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5543 | -0.8601 | -1.074 | -0.1866 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.24283 | 91.29 | -5.402 | -0.9039 | -2.194 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3922 | 1.286 | 0.05809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8761 | 0.05841 | 0.7967 | 0.7107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9668 | 0.6903 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.24283</span> | 91.29 | 0.004506 | 0.2882 | 0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009720 | 0.5968 | 1.286 | 0.05809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8761 | 0.05841 | 0.7967 | 0.7107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.554 | 0.9668 | 0.6903 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.383 | 1.129 | 0.03939 | -0.1057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3410 | 1.013 | -4.733 | 2.907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.07460 | -0.06623 | -0.4732 | -0.6761 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6495 | 1.823 | -0.1637 | -1.832 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 473.20973 | 1.005 | -1.204 | -0.9260 | -0.9311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.021 | -1.031 | 0.2279 | -0.8912 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7638 | -0.8760 | -0.7872 | -1.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5548 | -0.8600 | -1.075 | -0.1862 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.20973 | 91.43 | -5.404 | -0.9039 | -2.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3917 | 1.288 | 0.05799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8760 | 0.05843 | 0.7966 | 0.7102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.553 | 0.9669 | 0.6900 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.20973</span> | 91.43 | 0.004500 | 0.2882 | 0.1115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009716 | 0.5967 | 1.288 | 0.05799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8760 | 0.05843 | 0.7966 | 0.7102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.553 | 0.9669 | 0.6900 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 473.17178 | 1.005 | -1.205 | -0.9261 | -0.9307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.022 | -1.032 | 0.2326 | -0.8959 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7641 | -0.8754 | -0.7876 | -1.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5554 | -0.8593 | -1.075 | -0.1863 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.17178 | 91.43 | -5.405 | -0.9040 | -2.193 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.634 | 0.3910 | 1.289 | 0.05785 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8759 | 0.05844 | 0.7963 | 0.7092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.552 | 0.9676 | 0.6896 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.17178</span> | 91.43 | 0.004492 | 0.2882 | 0.1116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009711 | 0.5965 | 1.289 | 0.05785 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8759 | 0.05844 | 0.7963 | 0.7092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.552 | 0.9676 | 0.6896 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 472.97479 | 1.005 | -1.215 | -0.9262 | -0.9287 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.025 | -1.041 | 0.2575 | -0.9212 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7657 | -0.8720 | -0.7899 | -1.094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5585 | -0.8552 | -1.078 | -0.1866 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.97479 | 91.45 | -5.415 | -0.9041 | -2.191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.637 | 0.3872 | 1.300 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8752 | 0.05854 | 0.7946 | 0.7037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.549 | 0.9715 | 0.6874 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.97479</span> | 91.45 | 0.004449 | 0.2882 | 0.1118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009685 | 0.5956 | 1.300 | 0.05712 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8752 | 0.05854 | 0.7946 | 0.7037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.549 | 0.9715 | 0.6874 | 2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 472.26932 | 1.006 | -1.253 | -0.9268 | -0.9205 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.035 | -1.074 | 0.3572 | -1.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7723 | -0.8583 | -0.7991 | -1.118 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5709 | -0.8392 | -1.088 | -0.1877 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.26932 | 91.55 | -5.453 | -0.9046 | -2.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.648 | 0.3719 | 1.341 | 0.05419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8725 | 0.05894 | 0.7878 | 0.6819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.534 | 0.9868 | 0.6787 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.26932</span> | 91.55 | 0.004282 | 0.2881 | 0.1127 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009582 | 0.5919 | 1.341 | 0.05419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8725 | 0.05894 | 0.7878 | 0.6819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.534 | 0.9868 | 0.6787 | 2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 470.90347 | 1.012 | -1.408 | -0.9286 | -0.8872 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.078 | -1.207 | 0.7550 | -1.427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7985 | -0.8024 | -0.8343 | -1.204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6170 | -0.7722 | -1.128 | -0.1957 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 470.90347 | 92.06 | -5.608 | -0.9062 | -2.150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.691 | 0.3105 | 1.506 | 0.04245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8616 | 0.06056 | 0.7621 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.051 | 0.6438 | 2.029 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.90347</span> | 92.06 | 0.003670 | 0.2878 | 0.1165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009180 | 0.5770 | 1.506 | 0.04245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8616 | 0.06056 | 0.7621 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 1.051 | 0.6438 | 2.029 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 16.46 | 0.7178 | 1.137 | -0.2842 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06515 | -1.058 | -6.810 | -2.325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1903 | -0.6630 | 1.424 | -9.046 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.659 | 8.235 | -7.307 | -1.506 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 469.55066 | 1.016 | -1.623 | -0.9529 | -0.8214 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.136 | -1.353 | 1.295 | -1.874 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8595 | -0.6716 | -0.9513 | -1.204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7087 | -0.8316 | -0.9499 | -0.4083 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.55066 | 92.47 | -5.823 | -0.9279 | -2.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.749 | 0.2437 | 1.731 | 0.02949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.06435 | 0.6766 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.371 | 0.9940 | 0.7978 | 1.771 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.55066</span> | 92.47 | 0.002960 | 0.2834 | 0.1245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008661 | 0.5606 | 1.731 | 0.02949 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8363 | 0.06435 | 0.6766 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.371 | 0.9940 | 0.7978 | 1.771 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.003 | 0.4823 | 0.6025 | -0.2481 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.135 | 0.1015 | -5.875 | -8.309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8363 | -0.7839 | 1.711 | -6.097 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.755 | 1.794 | 4.040 | -0.5408 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 471.32255 | 1.022 | -1.880 | -1.043 | -0.7426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.107 | -1.512 | 1.956 | -1.964 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9773 | -0.5429 | -1.097 | -1.122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6469 | -0.5662 | -0.9027 | -0.4752 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 471.32255 | 93.00 | -6.080 | -1.008 | -2.005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.719 | 0.1705 | 2.005 | 0.02687 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7874 | 0.06809 | 0.5704 | 0.6787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.444 | 1.248 | 0.8385 | 1.690 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 471.32255</span> | 93.00 | 0.002289 | 0.2674 | 0.1347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008922 | 0.5425 | 2.005 | 0.02687 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7874 | 0.06809 | 0.5704 | 0.6787 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.444 | 1.248 | 0.8385 | 1.690 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 468.82475 | 1.022 | -1.709 | -0.9836 | -0.7948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.126 | -1.406 | 1.521 | -1.898 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8984 | -0.6279 | -1.001 | -1.172 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6845 | -0.7440 | -0.9371 | -0.4303 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.82475 | 92.98 | -5.909 | -0.9551 | -2.057 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.738 | 0.2191 | 1.824 | 0.02879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8201 | 0.06562 | 0.6400 | 0.6333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.400 | 1.078 | 0.8088 | 1.744 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.82475</span> | 92.98 | 0.002714 | 0.2779 | 0.1278 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008755 | 0.5546 | 1.824 | 0.02879 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8201 | 0.06562 | 0.6400 | 0.6333 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.400 | 1.078 | 0.8088 | 1.744 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.86 | 0.3767 | -0.09575 | -0.1893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.313 | -0.2132 | -3.864 | -4.927 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.292 | -1.079 | -0.1017 | -3.329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.248 | 8.116 | 3.916 | -0.3530 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 467.75171 | 1.017 | -1.816 | -0.9824 | -0.7623 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.067 | -1.470 | 1.678 | -1.962 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9501 | -0.5667 | -0.9995 | -1.140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5909 | -0.8204 | -1.012 | -0.4878 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.75171 | 92.51 | -6.016 | -0.9541 | -2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.679 | 0.1896 | 1.889 | 0.02693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7987 | 0.06740 | 0.6413 | 0.6622 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | 1.005 | 0.7438 | 1.674 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.75171</span> | 92.51 | 0.002440 | 0.2781 | 0.1320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.009285 | 0.5473 | 1.889 | 0.02693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7987 | 0.06740 | 0.6413 | 0.6622 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | 1.005 | 0.7438 | 1.674 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.72 | 0.1617 | -0.2966 | 0.1391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7722 | -0.6625 | -3.136 | -6.222 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.617 | -0.9189 | -0.2811 | -3.105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.05355 | 2.320 | -3.473 | -2.160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 467.28745 | 1.018 | -1.902 | -0.9107 | -0.7577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -1.517 | 1.777 | -1.860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8874 | -0.4787 | -0.8826 | -1.170 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6199 | -0.8544 | -0.9952 | -0.3962 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.28745 | 92.66 | -6.102 | -0.8902 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1682 | 1.931 | 0.02990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8247 | 0.06995 | 0.7268 | 0.6357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7587 | 1.785 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.28745</span> | 92.66 | 0.002239 | 0.2911 | 0.1327 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8247 | 0.06995 | 0.7268 | 0.6357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7587 | 1.785 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.75 | 0.1003 | 2.571 | 0.1450 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5415 | -1.471 | -1.062 | -1.774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.363 | 0.7539 | 2.182 | -3.357 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.337 | 0.2346 | -1.234 | -0.8531 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 469.68385 | 0.9954 | -1.950 | -1.032 | -0.7900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8810 | -1.433 | 1.783 | -1.785 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9418 | -0.5114 | -0.9107 | -1.204 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6798 | -0.8966 | -1.014 | -0.2565 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.68385 | 90.58 | -6.150 | -0.9984 | -2.052 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.493 | 0.2066 | 1.933 | 0.03207 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8021 | 0.06900 | 0.7062 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.405 | 0.9320 | 0.7422 | 1.955 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.68385</span> | 90.58 | 0.002133 | 0.2693 | 0.1284 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01118 | 0.5515 | 1.933 | 0.03207 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8021 | 0.06900 | 0.7062 | 0.6043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.405 | 0.9320 | 0.7422 | 1.955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 467.87907 | 1.005 | -1.909 | -0.9308 | -0.7628 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9639 | -1.503 | 1.779 | -1.847 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8965 | -0.4841 | -0.8880 | -1.173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6287 | -0.8610 | -0.9975 | -0.3740 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.87907 | 91.48 | -6.109 | -0.9081 | -2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.576 | 0.1745 | 1.931 | 0.03026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8209 | 0.06979 | 0.7229 | 0.6325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.466 | 0.9660 | 0.7566 | 1.812 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.87907</span> | 91.48 | 0.002222 | 0.2874 | 0.1320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01029 | 0.5435 | 1.931 | 0.03026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8209 | 0.06979 | 0.7229 | 0.6325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.466 | 0.9660 | 0.7566 | 1.812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 467.53566 | 1.009 | -1.902 | -0.9117 | -0.7577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9793 | -1.516 | 1.778 | -1.859 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8880 | -0.4790 | -0.8835 | -1.168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8545 | -0.9947 | -0.3959 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.53566 | 91.86 | -6.102 | -0.8912 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1685 | 1.931 | 0.02992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7261 | 0.6369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7591 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.53566</span> | 91.86 | 0.002239 | 0.2909 | 0.1326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7261 | 0.6369 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7591 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 467.26444 | 1.016 | -1.902 | -0.9109 | -0.7577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9795 | -1.516 | 1.777 | -1.860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8875 | -0.4788 | -0.8828 | -1.169 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6198 | -0.8544 | -0.9951 | -0.3961 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.26444 | 92.48 | -6.102 | -0.8905 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1683 | 1.931 | 0.02990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8246 | 0.06995 | 0.7266 | 0.6360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7588 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.26444</span> | 92.48 | 0.002239 | 0.2910 | 0.1326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02990 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8246 | 0.06995 | 0.7266 | 0.6360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.476 | 0.9723 | 0.7588 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.458 | 0.09189 | 2.450 | 0.1713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5320 | -1.492 | -1.346 | -2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.374 | 0.8089 | 1.804 | -5.854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.303 | 0.2787 | -1.170 | -0.8602 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 467.25360 | 1.017 | -1.902 | -0.9116 | -0.7577 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9793 | -1.516 | 1.778 | -1.859 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8879 | -0.4790 | -0.8833 | -1.168 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.8545 | -0.9948 | -0.3959 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.2536 | 92.51 | -6.102 | -0.8910 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1685 | 1.931 | 0.02992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7263 | 0.6374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7590 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.2536</span> | 92.51 | 0.002239 | 0.2909 | 0.1326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01013 | 0.5420 | 1.931 | 0.02992 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8245 | 0.06994 | 0.7263 | 0.6374 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9722 | 0.7590 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.196 | 0.08873 | 2.446 | 0.1672 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5342 | -1.484 | -1.056 | -1.956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.373 | 0.7965 | 2.077 | -5.722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.292 | 0.2471 | -1.040 | -0.8496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 467.24389 | 1.015 | -1.902 | -0.9128 | -0.7578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9790 | -1.515 | 1.778 | -1.858 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8886 | -0.4794 | -0.8844 | -1.165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6188 | -0.8546 | -0.9942 | -0.3955 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.24389 | 92.37 | -6.102 | -0.8922 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.592 | 0.1688 | 1.931 | 0.02995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8242 | 0.06993 | 0.7255 | 0.6400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9721 | 0.7595 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.24389</span> | 92.37 | 0.002239 | 0.2907 | 0.1326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01014 | 0.5421 | 1.931 | 0.02995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8242 | 0.06993 | 0.7255 | 0.6400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9721 | 0.7595 | 1.786 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -15.43 | 0.07336 | 2.305 | 0.1893 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5256 | -1.495 | -1.329 | -2.142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.357 | 0.9382 | 1.940 | -3.165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.157 | 0.2760 | -0.9277 | -0.8566 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 467.22397 | 1.017 | -1.902 | -0.9138 | -0.7581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9782 | -1.514 | 1.778 | -1.857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | -0.4797 | -0.8863 | -1.164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6190 | -0.8552 | -0.9945 | -0.3935 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.22397 | 92.56 | -6.102 | -0.8930 | -2.020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.591 | 0.1692 | 1.931 | 0.02998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8241 | 0.06992 | 0.7241 | 0.6409 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9715 | 0.7593 | 1.789 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.22397</span> | 92.56 | 0.002238 | 0.2905 | 0.1326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01015 | 0.5422 | 1.931 | 0.02998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8241 | 0.06992 | 0.7241 | 0.6409 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9715 | 0.7593 | 1.789 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.612 | 0.07601 | 2.377 | 0.1597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5308 | -1.476 | -1.038 | -1.834 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.332 | 0.7679 | 2.039 | -3.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.288 | 0.2037 | -1.093 | -0.8313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 467.20858 | 1.016 | -1.903 | -0.9153 | -0.7584 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9772 | -1.513 | 1.777 | -1.856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8896 | -0.4802 | -0.8882 | -1.164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8560 | -0.9946 | -0.3915 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.20858 | 92.46 | -6.103 | -0.8944 | -2.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.590 | 0.1698 | 1.931 | 0.03001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8238 | 0.06990 | 0.7227 | 0.6411 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9707 | 0.7591 | 1.791 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.20858</span> | 92.46 | 0.002236 | 0.2902 | 0.1325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01016 | 0.5423 | 1.931 | 0.03001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8238 | 0.06990 | 0.7227 | 0.6411 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9707 | 0.7591 | 1.791 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.651 | 0.07137 | 2.259 | 0.1744 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5171 | -1.486 | -1.304 | -1.934 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.324 | 0.7910 | 1.690 | -3.053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.233 | 0.1999 | -1.046 | -0.8164 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 467.19548 | 1.017 | -1.903 | -0.9170 | -0.7588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9762 | -1.512 | 1.778 | -1.855 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8906 | -0.4808 | -0.8898 | -1.163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6195 | -0.8567 | -0.9946 | -0.3897 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.19548 | 92.56 | -6.103 | -0.8959 | -2.021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.589 | 0.1705 | 1.931 | 0.03005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06989 | 0.7215 | 0.6417 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9701 | 0.7592 | 1.793 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.19548</span> | 92.56 | 0.002235 | 0.2899 | 0.1325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01017 | 0.5425 | 1.931 | 0.03005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06989 | 0.7215 | 0.6417 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9701 | 0.7592 | 1.793 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.695 | 0.07360 | 2.256 | 0.1610 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5147 | -1.467 | -1.275 | -1.734 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.307 | 0.8740 | 2.039 | -5.568 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.898 | -0.2550 | -1.273 | -0.7762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 467.17845 | 1.016 | -1.904 | -0.9175 | -0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9751 | -1.510 | 1.777 | -1.854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8907 | -0.4813 | -0.8918 | -1.161 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6194 | -0.8571 | -0.9949 | -0.3876 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.17845 | 92.50 | -6.104 | -0.8963 | -2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.588 | 0.1711 | 1.930 | 0.03007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06987 | 0.7201 | 0.6433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9697 | 0.7589 | 1.796 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.17845</span> | 92.50 | 0.002234 | 0.2898 | 0.1324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01018 | 0.5427 | 1.930 | 0.03007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8234 | 0.06987 | 0.7201 | 0.6433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9697 | 0.7589 | 1.796 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.021 | 0.06308 | 2.194 | 0.1658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5050 | -1.471 | -1.283 | -1.811 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.304 | 0.7659 | 1.629 | -2.860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.234 | 0.1434 | -1.025 | -0.7796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 467.16518 | 1.015 | -1.904 | -0.9192 | -0.7596 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9742 | -1.509 | 1.777 | -1.853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8917 | -0.4819 | -0.8931 | -1.160 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6190 | -0.8574 | -0.9946 | -0.3864 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.16518 | 92.39 | -6.104 | -0.8978 | -2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.587 | 0.1719 | 1.931 | 0.03011 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8229 | 0.06985 | 0.7191 | 0.6447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9694 | 0.7592 | 1.797 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.16518</span> | 92.39 | 0.002234 | 0.2895 | 0.1324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01019 | 0.5429 | 1.931 | 0.03011 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8229 | 0.06985 | 0.7191 | 0.6447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.477 | 0.9694 | 0.7592 | 1.797 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.15 | 0.05292 | 2.063 | 0.1800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4962 | -1.473 | -0.9311 | -1.912 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.287 | 0.8965 | 1.659 | -5.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.766 | -0.2649 | -1.228 | -0.7899 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 467.14275 | 1.016 | -1.904 | -0.9201 | -0.7599 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9736 | -1.507 | 1.777 | -1.851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8922 | -0.4826 | -0.8948 | -1.157 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6182 | -0.8576 | -0.9943 | -0.3850 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.14275 | 92.43 | -6.104 | -0.8986 | -2.022 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.586 | 0.1725 | 1.931 | 0.03014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8227 | 0.06984 | 0.7179 | 0.6470 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 0.9693 | 0.7594 | 1.799 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.14275</span> | 92.43 | 0.002233 | 0.2893 | 0.1324 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01019 | 0.5430 | 1.931 | 0.03014 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8227 | 0.06984 | 0.7179 | 0.6470 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.478 | 0.9693 | 0.7594 | 1.799 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -6.177 | 0.04590 | 2.051 | 0.1758 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4936 | -1.461 | -0.9893 | -1.828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.266 | 0.7615 | 1.545 | -5.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.792 | -0.2512 | -1.220 | -0.7551 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 467.10820 | 1.017 | -1.905 | -0.9220 | -0.7605 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9724 | -1.505 | 1.777 | -1.849 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8932 | -0.4835 | -0.8976 | -1.151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6164 | -0.8576 | -0.9935 | -0.3828 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.1082 | 92.55 | -6.105 | -0.9003 | -2.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.585 | 0.1737 | 1.930 | 0.03020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8223 | 0.06981 | 0.7158 | 0.6522 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 0.9692 | 0.7601 | 1.802 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.1082</span> | 92.55 | 0.002232 | 0.2890 | 0.1323 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01020 | 0.5433 | 1.930 | 0.03020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8223 | 0.06981 | 0.7158 | 0.6522 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.480 | 0.9692 | 0.7601 | 1.802 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.449 | 0.03092 | 2.044 | 0.1611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4934 | -1.430 | -1.221 | -1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.229 | 0.8691 | 1.875 | -2.123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.605 | -0.2558 | -1.009 | -0.7122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 467.10106 | 1.014 | -1.905 | -0.9236 | -0.7611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9712 | -1.502 | 1.777 | -1.847 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8940 | -0.4849 | -0.9012 | -1.147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6148 | -0.8578 | -0.9928 | -0.3803 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.10106 | 92.28 | -6.105 | -0.9017 | -2.023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.584 | 0.1749 | 1.930 | 0.03026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8220 | 0.06977 | 0.7132 | 0.6562 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 0.9690 | 0.7607 | 1.805 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.10106</span> | 92.28 | 0.002232 | 0.2887 | 0.1322 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01022 | 0.5436 | 1.930 | 0.03026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8220 | 0.06977 | 0.7132 | 0.6562 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.482 | 0.9690 | 0.7607 | 1.805 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -24.17 | 0.001665 | 1.814 | 0.1960 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4738 | -1.444 | -0.8955 | -1.908 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.221 | 0.7910 | 1.755 | -3.560 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -2.244 | -0.2675 | -0.8607 | -0.7175 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 467.04630 | 1.016 | -1.905 | -0.9246 | -0.7619 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9696 | -1.499 | 1.777 | -1.845 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8944 | -0.4866 | -0.9055 | -1.143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6133 | -0.8582 | -0.9923 | -0.3775 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.0463 | 92.45 | -6.105 | -0.9026 | -2.024 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.582 | 0.1762 | 1.930 | 0.03032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8218 | 0.06972 | 0.7101 | 0.6601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 0.9686 | 0.7611 | 1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.0463</span> | 92.45 | 0.002231 | 0.2885 | 0.1321 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01023 | 0.5439 | 1.930 | 0.03032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8218 | 0.06972 | 0.7101 | 0.6601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.484 | 0.9686 | 0.7611 | 1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.647 | -0.007887 | 1.876 | 0.1719 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4730 | -1.410 | -0.8701 | -1.589 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.184 | 0.7244 | 1.544 | -4.110 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.544 | -0.3120 | -0.9430 | -0.6527 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 467.02543 | 1.017 | -1.906 | -0.9263 | -0.7625 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9684 | -1.497 | 1.777 | -1.843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8954 | -0.4879 | -0.9089 | -1.137 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6116 | -0.8583 | -0.9915 | -0.3753 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 467.02543 | 92.58 | -6.106 | -0.9041 | -2.025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.581 | 0.1775 | 1.930 | 0.03038 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8214 | 0.06968 | 0.7076 | 0.6649 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 0.9686 | 0.7618 | 1.811 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 467.02543</span> | 92.58 | 0.002230 | 0.2882 | 0.1320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01025 | 0.5443 | 1.930 | 0.03038 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8214 | 0.06968 | 0.7076 | 0.6649 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.486 | 0.9686 | 0.7618 | 1.811 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 12.94 | -0.02385 | 1.879 | 0.1542 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4735 | -1.378 | -0.8918 | -1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.131 | 0.6590 | 1.631 | -3.618 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.430 | -0.2321 | -0.8462 | -0.6495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 466.99646 | 1.016 | -1.906 | -0.9273 | -0.7632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9670 | -1.494 | 1.776 | -1.841 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8958 | -0.4892 | -0.9132 | -1.133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6101 | -0.8587 | -0.9911 | -0.3725 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.99646 | 92.42 | -6.106 | -0.9050 | -2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.579 | 0.1788 | 1.930 | 0.03043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8212 | 0.06964 | 0.7044 | 0.6690 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 0.9682 | 0.7622 | 1.814 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.99646</span> | 92.42 | 0.002230 | 0.2880 | 0.1319 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01026 | 0.5446 | 1.930 | 0.03043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8212 | 0.06964 | 0.7044 | 0.6690 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.488 | 0.9682 | 0.7622 | 1.814 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.590 | -0.05004 | 1.738 | 0.1737 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4573 | -1.378 | -0.8791 | -1.534 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.117 | 0.8064 | 1.528 | -3.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8220 | 0.1296 | -0.3838 | -0.6246 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 466.97639 | 1.017 | -1.906 | -0.9282 | -0.7640 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9655 | -1.490 | 1.776 | -1.839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8964 | -0.4910 | -0.9175 | -1.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6092 | -0.8593 | -0.9910 | -0.3693 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.97639 | 92.52 | -6.106 | -0.9059 | -2.026 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.578 | 0.1803 | 1.930 | 0.03049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8210 | 0.06959 | 0.7013 | 0.6726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9676 | 0.7623 | 1.818 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.97639</span> | 92.52 | 0.002230 | 0.2878 | 0.1318 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01028 | 0.5450 | 1.930 | 0.03049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8210 | 0.06959 | 0.7013 | 0.6726 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9676 | 0.7623 | 1.818 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.027 | -0.06281 | 1.755 | 0.1604 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4507 | -1.349 | -0.8053 | -1.299 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.095 | 0.6623 | 1.032 | -2.794 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8171 | 0.07286 | -0.3538 | -0.5889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 466.96001 | 1.015 | -1.906 | -0.9299 | -0.7649 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9637 | -1.486 | 1.775 | -1.837 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8976 | -0.4931 | -0.9192 | -1.125 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6091 | -0.8600 | -0.9916 | -0.3657 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.96001 | 92.40 | -6.106 | -0.9074 | -2.027 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.576 | 0.1824 | 1.930 | 0.03055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8205 | 0.06953 | 0.7000 | 0.6758 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9669 | 0.7618 | 1.823 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.96001</span> | 92.40 | 0.002230 | 0.2875 | 0.1317 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01029 | 0.5455 | 1.930 | 0.03055 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8205 | 0.06953 | 0.7000 | 0.6758 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.489 | 0.9669 | 0.7618 | 1.823 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.315 | -0.08361 | 1.595 | 0.1755 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4289 | -1.331 | -0.8104 | -1.428 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.055 | 0.7710 | 1.242 | -2.826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.346 | -0.3282 | -0.6399 | -0.5709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 466.94053 | 1.016 | -1.905 | -0.9315 | -0.7662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9617 | -1.480 | 1.774 | -1.835 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8987 | -0.4954 | -0.9193 | -1.121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6079 | -0.8601 | -0.9919 | -0.3632 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.94053 | 92.48 | -6.105 | -0.9088 | -2.029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.574 | 0.1849 | 1.929 | 0.03061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06946 | 0.6999 | 0.6792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 0.9668 | 0.7615 | 1.826 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.94053</span> | 92.48 | 0.002231 | 0.2873 | 0.1315 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01031 | 0.5461 | 1.929 | 0.03061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06946 | 0.6999 | 0.6792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.490 | 0.9668 | 0.7615 | 1.826 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.448 | -0.09452 | 1.578 | 0.1631 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4178 | -1.275 | -0.7880 | -1.291 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.013 | 0.7275 | 1.336 | -0.1176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.297 | -0.2757 | -0.6338 | -0.5586 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 466.92529 | 1.015 | -1.905 | -0.9321 | -0.7676 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9593 | -1.476 | 1.775 | -1.833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8992 | -0.4984 | -0.9232 | -1.122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6063 | -0.8604 | -0.9916 | -0.3612 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.92529 | 92.34 | -6.105 | -0.9093 | -2.030 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.572 | 0.1871 | 1.930 | 0.03066 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8198 | 0.06938 | 0.6971 | 0.6791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 0.9666 | 0.7618 | 1.828 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.92529</span> | 92.34 | 0.002233 | 0.2871 | 0.1313 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01034 | 0.5466 | 1.930 | 0.03066 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8198 | 0.06938 | 0.6971 | 0.6791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.492 | 0.9666 | 0.7618 | 1.828 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -12.72 | -0.09950 | 1.479 | 0.1754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4012 | -1.242 | -0.7866 | -1.413 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9668 | 0.6187 | 0.9349 | -2.630 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.260 | -0.3489 | -0.4063 | -0.5476 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 466.89942 | 1.016 | -1.904 | -0.9326 | -0.7693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -1.470 | 1.775 | -1.832 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8995 | -0.5006 | -0.9260 | -1.122 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6055 | -0.8609 | -0.9921 | -0.3587 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.89942 | 92.48 | -6.104 | -0.9097 | -2.032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.569 | 0.1897 | 1.929 | 0.03069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8197 | 0.06931 | 0.6950 | 0.6788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9661 | 0.7614 | 1.831 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.89942</span> | 92.48 | 0.002235 | 0.2871 | 0.1311 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01037 | 0.5473 | 1.929 | 0.03069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8197 | 0.06931 | 0.6950 | 0.6788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9661 | 0.7614 | 1.831 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.439 | -0.09008 | 1.544 | 0.1555 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3845 | -1.174 | -0.7709 | -1.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9305 | 0.6799 | 1.153 | -2.871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.766 | -0.2963 | -0.5389 | -0.5305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 466.87885 | 1.016 | -1.902 | -0.9335 | -0.7713 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9544 | -1.465 | 1.775 | -1.831 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8988 | -0.5028 | -0.9291 | -1.120 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6025 | -0.8609 | -0.9918 | -0.3573 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.87885 | 92.42 | -6.102 | -0.9106 | -2.034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.567 | 0.1922 | 1.930 | 0.03072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06925 | 0.6928 | 0.6803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 0.9661 | 0.7616 | 1.833 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.87885</span> | 92.42 | 0.002239 | 0.2869 | 0.1309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01039 | 0.5479 | 1.930 | 0.03072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8200 | 0.06925 | 0.6928 | 0.6803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.497 | 0.9661 | 0.7616 | 1.833 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.274 | -0.09794 | 1.477 | 0.1445 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3711 | -1.126 | -0.7697 | -1.253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9213 | 0.5797 | 0.6929 | -2.254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4364 | 0.05549 | -0.07007 | -0.5105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 466.87374 | 1.017 | -1.901 | -0.9363 | -0.7725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9523 | -1.459 | 1.775 | -1.829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9004 | -0.5050 | -0.9284 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6029 | -0.8616 | -0.9930 | -0.3542 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.87374 | 92.57 | -6.101 | -0.9131 | -2.035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.565 | 0.1945 | 1.929 | 0.03078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8193 | 0.06919 | 0.6933 | 0.6817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9655 | 0.7605 | 1.836 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.87374</span> | 92.57 | 0.002241 | 0.2864 | 0.1307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01041 | 0.5485 | 1.929 | 0.03078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8193 | 0.06919 | 0.6933 | 0.6817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9655 | 0.7605 | 1.836 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 13.60 | -0.09484 | 1.445 | 0.1251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3584 | -1.070 | -0.7354 | -1.048 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8551 | 0.6144 | 0.8824 | -0.009520 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4410 | 0.04024 | -0.2274 | -0.5153 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 466.85547 | 1.016 | -1.900 | -0.9388 | -0.7737 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9500 | -1.454 | 1.774 | -1.828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9020 | -0.5070 | -0.9271 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6040 | -0.8622 | -0.9946 | -0.3509 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.85547 | 92.42 | -6.100 | -0.9152 | -2.036 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.562 | 0.1970 | 1.929 | 0.03083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8186 | 0.06913 | 0.6942 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 0.9648 | 0.7592 | 1.841 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.85547</span> | 92.42 | 0.002243 | 0.2859 | 0.1305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01044 | 0.5491 | 1.929 | 0.03083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8186 | 0.06913 | 0.6942 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.495 | 0.9648 | 0.7592 | 1.841 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.539 | -0.09755 | 1.262 | 0.1433 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3291 | -1.038 | -0.7482 | -1.225 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8087 | 0.5023 | 0.8171 | -0.005344 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4685 | 0.01356 | -0.1499 | -0.5112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 466.84409 | 1.016 | -1.899 | -0.9408 | -0.7751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9477 | -1.449 | 1.774 | -1.826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | -0.5088 | -0.9269 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6048 | -0.8630 | -0.9960 | -0.3473 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.84409 | 92.47 | -6.099 | -0.9171 | -2.037 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.560 | 0.1996 | 1.929 | 0.03088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8179 | 0.06907 | 0.6944 | 0.6816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9641 | 0.7580 | 1.845 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.84409</span> | 92.47 | 0.002245 | 0.2856 | 0.1304 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01046 | 0.5497 | 1.929 | 0.03088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8179 | 0.06907 | 0.6944 | 0.6816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9641 | 0.7580 | 1.845 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.205 | -0.09489 | 1.201 | 0.1289 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3142 | -0.9889 | -0.7667 | -1.156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7401 | 0.5570 | 1.301 | -1.479 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.860 | -0.4540 | -0.5722 | -0.5005 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 466.83069 | 1.016 | -1.897 | -0.9405 | -0.7762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9462 | -1.443 | 1.775 | -1.825 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9047 | -0.5101 | -0.9307 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6046 | -0.8636 | -0.9969 | -0.3435 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.83069 | 92.41 | -6.097 | -0.9168 | -2.039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.559 | 0.2019 | 1.929 | 0.03091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8175 | 0.06904 | 0.6917 | 0.6819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9635 | 0.7572 | 1.850 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.83069</span> | 92.41 | 0.002250 | 0.2856 | 0.1302 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01048 | 0.5503 | 1.929 | 0.03091 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8175 | 0.06904 | 0.6917 | 0.6819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9635 | 0.7572 | 1.850 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 466.81923 | 1.016 | -1.894 | -0.9398 | -0.7773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9447 | -1.438 | 1.775 | -1.824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9056 | -0.5113 | -0.9343 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6049 | -0.8643 | -0.9979 | -0.3395 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.81923 | 92.43 | -6.094 | -0.9162 | -2.040 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.557 | 0.2043 | 1.930 | 0.03094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8171 | 0.06900 | 0.6890 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9628 | 0.7563 | 1.854 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.81923</span> | 92.43 | 0.002255 | 0.2857 | 0.1301 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01049 | 0.5509 | 1.930 | 0.03094 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8171 | 0.06900 | 0.6890 | 0.6818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.494 | 0.9628 | 0.7563 | 1.854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 466.78977 | 1.016 | -1.887 | -0.9376 | -0.7810 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9400 | -1.422 | 1.776 | -1.820 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9086 | -0.5153 | -0.9461 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6057 | -0.8666 | -1.001 | -0.3266 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.78977 | 92.47 | -6.087 | -0.9142 | -2.043 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.552 | 0.2120 | 1.930 | 0.03105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8159 | 0.06889 | 0.6804 | 0.6815 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9606 | 0.7533 | 1.870 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.78977</span> | 92.47 | 0.002272 | 0.2861 | 0.1296 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01054 | 0.5528 | 1.930 | 0.03105 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8159 | 0.06889 | 0.6804 | 0.6815 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.493 | 0.9606 | 0.7533 | 1.870 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 466.76586 | 1.017 | -1.875 | -0.9340 | -0.7871 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9321 | -1.394 | 1.779 | -1.814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9134 | -0.5218 | -0.9656 | -1.119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6071 | -0.8705 | -1.007 | -0.3052 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.76586 | 92.53 | -6.075 | -0.9110 | -2.049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.545 | 0.2247 | 1.931 | 0.03121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8139 | 0.06870 | 0.6661 | 0.6811 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 0.9569 | 0.7485 | 1.896 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.76586</span> | 92.53 | 0.002300 | 0.2868 | 0.1288 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01062 | 0.5559 | 1.931 | 0.03121 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8139 | 0.06870 | 0.6661 | 0.6811 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.491 | 0.9569 | 0.7485 | 1.896 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 10.71 | -0.05605 | 1.440 | 0.09508 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1459 | -0.5070 | -0.9907 | -0.8007 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4069 | 0.2923 | 0.01818 | -1.553 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.109 | -0.3306 | -0.3991 | -0.2309 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 466.72646 | 1.014 | -1.848 | -0.9815 | -0.8092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9160 | -1.342 | 1.783 | -1.808 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | -0.5322 | -0.9570 | -1.117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6032 | -0.8748 | -1.022 | -0.2748 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.72646 | 92.30 | -6.048 | -0.9533 | -2.072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2483 | 1.933 | 0.03140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8182 | 0.06840 | 0.6724 | 0.6828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9528 | 0.7357 | 1.933 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.72646</span> | 92.30 | 0.002362 | 0.2782 | 0.1260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01080 | 0.5618 | 1.933 | 0.03140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8182 | 0.06840 | 0.6724 | 0.6828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9528 | 0.7357 | 1.933 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -13.11 | -0.01237 | -0.5306 | 0.001870 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01074 | -0.001553 | -0.5011 | -1.124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5240 | 0.3999 | 0.1337 | 0.6209 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3667 | -0.5464 | -0.9326 | -0.1861 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 466.72714 | 1.014 | -1.830 | -0.9704 | -0.8250 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9153 | -1.342 | 1.791 | -1.785 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9449 | -0.5943 | -0.9266 | -1.116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5962 | -0.8737 | -1.020 | -0.2698 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.72714 | 92.32 | -6.030 | -0.9434 | -2.087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2486 | 1.936 | 0.03205 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8009 | 0.06660 | 0.6946 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.504 | 0.9539 | 0.7372 | 1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.72714</span> | 92.32 | 0.002405 | 0.2802 | 0.1240 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01081 | 0.5618 | 1.936 | 0.03205 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8009 | 0.06660 | 0.6946 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.504 | 0.9539 | 0.7372 | 1.939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 466.69721 | 1.015 | -1.839 | -0.9760 | -0.8170 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9156 | -1.342 | 1.787 | -1.797 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9238 | -0.5630 | -0.9420 | -1.117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5997 | -0.8742 | -1.021 | -0.2723 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.69721 | 92.41 | -6.039 | -0.9484 | -2.079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.528 | 0.2485 | 1.935 | 0.03173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8096 | 0.06750 | 0.6834 | 0.6836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9534 | 0.7365 | 1.936 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69721</span> | 92.41 | 0.002383 | 0.2792 | 0.1250 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01080 | 0.5618 | 1.935 | 0.03173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8096 | 0.06750 | 0.6834 | 0.6836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9534 | 0.7365 | 1.936 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.5723 | 0.006769 | -0.2879 | -0.06332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01114 | -0.03155 | -0.3915 | -0.7923 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3201 | -0.2330 | 0.8086 | -1.424 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3663 | -0.4815 | -0.7933 | -0.2384 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 466.73286 | 1.017 | -1.834 | -0.9731 | -0.8131 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9227 | -1.351 | 1.796 | -1.779 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9201 | -0.5595 | -0.9572 | -1.109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6142 | -0.8686 | -1.016 | -0.2440 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.73286 | 92.54 | -6.034 | -0.9458 | -2.075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.535 | 0.2444 | 1.938 | 0.03223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8111 | 0.06760 | 0.6723 | 0.6901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 0.9587 | 0.7409 | 1.970 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.73286</span> | 92.54 | 0.002396 | 0.2797 | 0.1255 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01072 | 0.5608 | 1.938 | 0.03223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8111 | 0.06760 | 0.6723 | 0.6901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.483 | 0.9587 | 0.7409 | 1.970 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 466.69733 | 1.015 | -1.838 | -0.9750 | -0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9176 | -1.345 | 1.790 | -1.791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9226 | -0.5619 | -0.9467 | -1.114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6033 | -0.8723 | -1.019 | -0.2644 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.69733 | 92.40 | -6.038 | -0.9475 | -2.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.530 | 0.2474 | 1.936 | 0.03188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8101 | 0.06754 | 0.6799 | 0.6863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9552 | 0.7382 | 1.945 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69733</span> | 92.40 | 0.002386 | 0.2794 | 0.1251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5615 | 1.936 | 0.03188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8101 | 0.06754 | 0.6799 | 0.6863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.496 | 0.9552 | 0.7382 | 1.945 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 466.69584 | 1.015 | -1.839 | -0.9754 | -0.8165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9164 | -1.343 | 1.788 | -1.794 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9231 | -0.5623 | -0.9445 | -1.114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6009 | -0.8731 | -1.020 | -0.2689 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.69584 | 92.37 | -6.039 | -0.9478 | -2.079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2480 | 1.935 | 0.03180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8099 | 0.06752 | 0.6815 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9544 | 0.7377 | 1.940 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.69584</span> | 92.37 | 0.002384 | 0.2793 | 0.1251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5617 | 1.935 | 0.03180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8099 | 0.06752 | 0.6815 | 0.6857 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9544 | 0.7377 | 1.940 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.069 | -0.001275 | -0.2861 | -0.04975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01387 | -0.05203 | -0.3437 | -0.7173 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2694 | -0.1778 | 0.5026 | 0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9213 | -0.7376 | -0.9765 | -0.1682 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 466.68962 | 1.016 | -1.839 | -0.9764 | -0.8159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9167 | -1.342 | 1.790 | -1.793 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9191 | -0.5597 | -0.9461 | -1.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8712 | -1.018 | -0.2680 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.68962 | 92.46 | -6.039 | -0.9488 | -2.078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2485 | 1.936 | 0.03184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8115 | 0.06760 | 0.6803 | 0.6854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9562 | 0.7392 | 1.941 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.68962</span> | 92.46 | 0.002385 | 0.2791 | 0.1251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5618 | 1.936 | 0.03184 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8115 | 0.06760 | 0.6803 | 0.6854 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9562 | 0.7392 | 1.941 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.342 | 0.001592 | -0.2787 | -0.05882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.004933 | -0.02534 | -0.4440 | -0.5467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1484 | -0.03146 | 0.4648 | -1.264 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3607 | -0.2274 | -0.5157 | -0.1312 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 139</span>| 466.68314 | 1.015 | -1.839 | -0.9751 | -0.8151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9166 | -1.339 | 1.792 | -1.792 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9160 | -0.5585 | -0.9470 | -1.115 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5998 | -0.8691 | -1.016 | -0.2676 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.68314 | 92.36 | -6.039 | -0.9476 | -2.077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.529 | 0.2501 | 1.937 | 0.03187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8128 | 0.06763 | 0.6797 | 0.6853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9582 | 0.7404 | 1.942 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.68314</span> | 92.36 | 0.002385 | 0.2794 | 0.1252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01079 | 0.5622 | 1.937 | 0.03187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8128 | 0.06763 | 0.6797 | 0.6853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.500 | 0.9582 | 0.7404 | 1.942 |</span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.258 |-0.0003497 | -0.2788 | -0.03383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01408 | 0.02647 | -0.2857 | -0.5956 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05089 | 0.05050 | 0.4395 | 0.8187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2669 | -0.06868 | -0.3694 | -0.1159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 140</span>| 466.67997 | 1.015 | -1.839 | -0.9739 | -0.8142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9180 | -1.339 | 1.794 | -1.790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | -0.5623 | -0.9494 | -1.116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8690 | -1.016 | -0.2664 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.67997 | 92.38 | -6.039 | -0.9465 | -2.077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.531 | 0.2499 | 1.938 | 0.03191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.67997</span> | 92.38 | 0.002385 | 0.2796 | 0.1254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5622 | 1.938 | 0.03191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> | M| Mixed Diff. | -1.882 |-7.391e+04 | -0.2259 | -0.03295 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.005718 | 0.01130 | -0.3842 | -0.4930 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04972 | -0.05953 | 0.5251 | -1.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3564 | -0.08212 | -0.3242 | -0.1008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 141</span>| 466.67997 | 1.015 | -1.839 | -0.9739 | -0.8142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9180 | -1.339 | 1.794 | -1.790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | -0.5623 | -0.9494 | -1.116 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6002 | -0.8690 | -1.016 | -0.2664 |</span> -<span class="r-out co"><span class="r-pr">#></span> | U| 466.67997 | 92.38 | -6.039 | -0.9465 | -2.077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.531 | 0.2499 | 1.938 | 0.03191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 466.67997</span> | 92.38 | 0.002385 | 0.2796 | 0.1254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01078 | 0.5622 | 1.938 | 0.03191 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8138 | 0.06752 | 0.6779 | 0.6846 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.499 | 0.9583 | 0.7410 | 1.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="va">f_nlmixr_sfo_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_const</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_saem_obs</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_obs</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_saem_obs</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_obs</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_tc</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_tc</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_saem_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_saem_obs_tc</span><span class="op">$</span><span class="va">nm</span>,</span> -<span class="r-in"> <span class="va">f_nlmixr_dfop_sfo_focei_obs_tc</span><span class="op">$</span><span class="va">nm</span></span> -<span class="r-in"><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_sfo_sfo_focei_const$nm 9 1082.4605</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_const$nm 11 814.4261</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_const$nm 13 870.2659</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_saem_obs$nm 12 788.8373</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_obs$nm 12 794.5194</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem_obs$nm 14 815.0797</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_obs$nm 14 834.8474</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_tc$nm 12 812.3296</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_tc$nm 14 819.4103</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_saem_obs_tc$nm 14 814.4248</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_fomc_sfo_focei_obs_tc$nm 14 787.4355</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem_obs_tc$nm 16 828.5143</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei_obs_tc$nm 16 811.1191</span> -<span class="r-in"><span class="co"># Currently, FOMC-SFO with two-component error by variable fitted by focei gives the</span></span> -<span class="r-in"><span class="co"># lowest AIC</span></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">)</span></span> -<span class="r-plt img"><img src="nlmixr.mmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/summary.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlmixr_fomc_sfo_focei_obs_tc</span><span class="op">)</span></span> -<span class="r-out co"><span class="r-pr">#></span> nlmixr version used for fitting: 2.0.6 </span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.1.0 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.1.2 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Mon Feb 28 14:50:18 2022 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Mon Feb 28 14:51:57 2022 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - (alpha/beta) * 1/((time/beta) + 1) * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + f_parent_to_A1 * (alpha/beta) * 1/((time/beta) + 1) *</span> -<span class="r-out co"><span class="r-pr">#></span> parent - k_A1 * A1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Degradation model predictions using RxODE</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 18.08 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance unique to each observed variable </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_A1 f_parent_qlogis log_alpha log_beta </span> -<span class="r-out co"><span class="r-pr">#></span> 93.1168 -5.3034 -0.9442 -0.1065 2.2909 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for error model parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low_parent rsd_high_parent sigma_low_A1 rsd_high_A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 1.15958 0.03005 1.15958 0.03005 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood calculated by focei </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 787.4 831.3 -379.7</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 93.6717 91.2552 96.0882</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 -6.3199 -8.4468 -4.1930</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -1.0089 -1.3823 -0.6356</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha -0.1616 -0.6624 0.3392</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 2.2088 1.6800 2.7376</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> prnt_0 lg__A1 f_prn_ lg_lph</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 0.372 </span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.786 -0.409 </span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.336 0.942 -0.306 </span> -<span class="r-out co"><span class="r-pr">#></span> log_beta -0.399 -0.759 0.248 -0.555</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects (omega):</span> -<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 eta.log_k_A1 eta.f_parent_qlogis eta.log_alpha</span> -<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 4.391 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 0.000 6.402 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis 0.000 0.000 0.1584 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_alpha 0.000 0.000 0.0000 0.3381</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_beta 0.000 0.000 0.0000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_beta</span> -<span class="r-out co"><span class="r-pr">#></span> eta.parent_0 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_k_A1 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.f_parent_qlogis 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_alpha 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> eta.log_beta 0.358</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> -<span class="r-out co"><span class="r-pr">#></span> sigma_low_parent rsd_high_parent sigma_low_A1 rsd_high_A1 </span> -<span class="r-out co"><span class="r-pr">#></span> 2.35616 0.00153 0.63564 0.08639 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 93.6717 9.126e+01 96.0882</span> -<span class="r-out co"><span class="r-pr">#></span> k_A1 0.0018 2.146e-04 0.0151</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_A1 0.2672 2.006e-01 0.3462</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 0.8508 5.156e-01 1.4038</span> -<span class="r-out co"><span class="r-pr">#></span> beta 9.1049 5.366e+00 15.4499</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_A1 0.2672</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.7328</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back</span> -<span class="r-out co"><span class="r-pr">#></span> parent 11.46 127.3 38.31</span> -<span class="r-out co"><span class="r-pr">#></span> A1 385.05 1279.1 NA</span> -<span class="r-in"><span class="co"># }</span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/nobs.mkinfit.html b/docs/dev/reference/nobs.mkinfit.html deleted file mode 100644 index 10f6550b..00000000 --- a/docs/dev/reference/nobs.mkinfit.html +++ /dev/null @@ -1,157 +0,0 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href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Number of observations on which an mkinfit object was fitted</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nobs.mkinfit.R" class="external-link"><code>R/nobs.mkinfit.R</code></a></small> - <div class="hidden name"><code>nobs.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Number of observations on which an mkinfit object was fitted</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/nobs.html" class="external-link">nobs</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An mkinfit object</p></dd> - - -<dt>...</dt> -<dd><p>For compatibility with the generic method</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The number of rows in the data included in the mkinfit object</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/parhist.html b/docs/dev/reference/parhist.html deleted file mode 100644 index 27fc116f..00000000 --- a/docs/dev/reference/parhist.html +++ /dev/null @@ -1,169 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" 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property="og:title" content="Plot parameter distributions from multistart objects — parhist"><meta property="og:description" content="Produces a boxplot with all parameters from the multiple runs, scaled -either by the parameters of the run with the highest likelihood, -or by their medians as proposed in the paper by Duchesne et al. (2021)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.1.2</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Functions and data</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Example evaluations of dimethenamid data from 2018 with nonlinear mixed-effects models</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot parameter distributions from multistart objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parhist.R" class="external-link"><code>R/parhist.R</code></a></small> - <div class="hidden name"><code>parhist.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Produces a boxplot with all parameters from the multiple runs, scaled -either by the parameters of the run with the highest likelihood, -or by their medians as proposed in the paper by Duchesne et al. (2021).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">parhist</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> llmin <span class="op">=</span> <span class="op">-</span><span class="cn">Inf</span>,</span> -<span> scale <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"best"</span>, <span class="st">"median"</span><span class="op">)</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomleft"</span>,</span> -<span> main <span class="op">=</span> <span class="st">""</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The <a href="multistart.html">multistart</a> object</p></dd> - - -<dt>llmin</dt> -<dd><p>The minimum likelihood of objects to be shown</p></dd> - - -<dt>scale</dt> -<dd><p>By default, scale parameters using the best available fit. -If 'median', parameters are scaled using the median parameters from all fits.</p></dd> - - -<dt>lpos</dt> -<dd><p>Positioning of the legend.</p></dd> - - -<dt>main</dt> -<dd><p>Title of the plot</p></dd> - - -<dt>...</dt> -<dd><p>Passed to <a href="https://rdrr.io/r/graphics/boxplot.html" class="external-link">boxplot</a></p></dd> - -</dl></div> - <div id="references"> - <h2>References</h2> - <p>Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="multistart.html">multistart</a></p></div> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/parms.html b/docs/dev/reference/parms.html deleted file mode 100644 index d4175d41..00000000 --- a/docs/dev/reference/parms.html +++ /dev/null @@ -1,296 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Extract model parameters — parms • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Extract model parameters — parms"><meta property="og:description" content="This function returns degradation model parameters as well as error -model parameters per default, in order to avoid working with a fitted model -without considering the error structure that was assumed for the fit."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Extract model parameters</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parms.R" class="external-link"><code>R/parms.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/saem.R" class="external-link"><code>R/saem.R</code></a></small> - <div class="hidden name"><code>parms.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function returns degradation model parameters as well as error -model parameters per default, in order to avoid working with a fitted model -without considering the error structure that was assumed for the fit.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span>, errparms <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, transformed <span class="op">=</span> <span class="cn">FALSE</span>, errparms <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for multistart</span></span> -<span><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, exclude_failed <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu">parms</span><span class="op">(</span><span class="va">object</span>, ci <span class="op">=</span> <span class="cn">FALSE</span>, covariates <span class="op">=</span> <span class="cn">NULL</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A fitted model object.</p></dd> - - -<dt>...</dt> -<dd><p>Not used</p></dd> - - -<dt>transformed</dt> -<dd><p>Should the parameters be returned as used internally -during the optimisation?</p></dd> - - -<dt>errparms</dt> -<dd><p>Should the error model parameters be returned -in addition to the degradation parameters?</p></dd> - - -<dt>exclude_failed</dt> -<dd><p>For <a href="multistart.html">multistart</a> objects, should rows for failed fits -be removed from the returned parameter matrix?</p></dd> - - -<dt>ci</dt> -<dd><p>Should a matrix with estimates and confidence interval boundaries -be returned? If FALSE (default), a vector of estimates is returned if no -covariates are given, otherwise a matrix of estimates is returned, with -each column corresponding to a row of the data frame holding the covariates</p></dd> - - -<dt>covariates</dt> -<dd><p>A data frame holding covariate values for which to -return parameter values. Only has an effect if 'ci' is FALSE.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>Depending on the object, a numeric vector of fitted model parameters, -a matrix (e.g. for mmkin row objects), or a list of matrices (e.g. for -mmkin objects with more than one row).</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="saem.html">saem</a>, <a href="multistart.html">multistart</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># mkinfit objects</span></span></span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma </span> -<span class="r-out co"><span class="r-pr">#></span> 82.4921598 0.3060633 4.6730124 </span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fit</span>, transformed <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent sigma </span> -<span class="r-out co"><span class="r-pr">#></span> 82.492160 -1.183963 4.673012 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># mmkin objects</span></span></span> -<span class="r-in"><span><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673</span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">[</span>, <span class="fl">2</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 82.666781678</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.009647805</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 7.040168584</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 92.6837649</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 0.4967832</span> -<span class="r-out co"><span class="r-pr">#></span> beta 14.1451255</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.9167519</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 91.058971589</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.044946770</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.002868336</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.526942415</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.221302196</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 88.52275400 82.666781678 86.8547308 91.7779306 82.14809450</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.05794659 0.009647805 0.2102974 0.1232258 0.00720421</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.15274487 7.040168584 3.6769645 6.4669234 6.50457673</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 95.558575 92.6837649 90.719787 98.383939 94.8481459</span> -<span class="r-out co"><span class="r-pr">#></span> alpha 1.338667 0.4967832 1.639099 1.074460 0.2805272</span> -<span class="r-out co"><span class="r-pr">#></span> beta 13.033315 14.1451255 5.007077 4.397126 6.9052224</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.847671 1.9167519 1.066063 3.146056 1.6222778</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.55213663 91.058971589 90.34509493 98.14858820 94.311323734</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.21954588 0.044946770 0.41232288 0.31697588 0.080663857</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.02957934 0.002868336 0.07581766 0.03260384 0.003425417</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.44845068 0.526942415 0.66091967 0.65322767 0.342652880</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.35690468 2.221302196 1.34169076 2.87159846 1.942067831</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span><span class="fu">parms</span><span class="op">(</span><span class="va">fits</span>, transformed <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $SFO</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 88.522754 82.666782 86.854731 91.777931 82.148094</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.848234 -4.641025 -1.559232 -2.093737 -4.933090</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.152745 7.040169 3.676964 6.466923 6.504577</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $FOMC</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 95.5585751 92.6837649 90.7197870 98.38393897 94.848146</span> -<span class="r-out co"><span class="r-pr">#></span> log_alpha 0.2916741 -0.6996015 0.4941466 0.07181816 -1.271085</span> -<span class="r-out co"><span class="r-pr">#></span> log_beta 2.5675088 2.6493701 1.6108523 1.48095106 1.932278</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.8476712 1.9167519 1.0660627 3.14605557 1.622278</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $DFOP</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 Dataset 7 Dataset 8 Dataset 9 Dataset 10</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 96.5521366 91.0589716 90.3450949 98.1485882 94.3113237</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 -1.5161940 -3.1022764 -0.8859486 -1.1489296 -2.5174647</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 -3.5206791 -5.8540232 -2.5794240 -3.4233253 -5.6765322</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.2069326 0.1078741 0.6673953 0.6332573 -0.6514943</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.3569047 2.2213022 1.3416908 2.8715985 1.9420678</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/parplot.html b/docs/dev/reference/parplot.html deleted file mode 100644 index ee2ec7b2..00000000 --- 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(2021)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot parameter variability of multistart objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/parplot.R" class="external-link"><code>R/parplot.R</code></a></small> - <div class="hidden name"><code>parplot.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Produces a boxplot with all parameters from the multiple runs, scaled -either by the parameters of the run with the highest likelihood, -or by their medians as proposed in the paper by Duchesne et al. (2021).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">parplot</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for multistart.saem.mmkin</span></span> -<span><span class="fu">parplot</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> llmin <span class="op">=</span> <span class="op">-</span><span class="cn">Inf</span>,</span> -<span> llquant <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> scale <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"best"</span>, <span class="st">"median"</span><span class="op">)</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"bottomleft"</span>,</span> -<span> main <span class="op">=</span> <span class="st">""</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The <a href="multistart.html">multistart</a> object</p></dd> - - -<dt>...</dt> -<dd><p>Passed to <a href="https://rdrr.io/r/graphics/boxplot.html" class="external-link">boxplot</a></p></dd> - - -<dt>llmin</dt> -<dd><p>The minimum likelihood of objects to be shown</p></dd> - - -<dt>llquant</dt> -<dd><p>Fractional value for selecting only the fits with higher -likelihoods. Overrides 'llmin'.</p></dd> - - -<dt>scale</dt> -<dd><p>By default, scale parameters using the best -available fit. -If 'median', parameters are scaled using the median parameters from all fits.</p></dd> - - -<dt>lpos</dt> -<dd><p>Positioning of the legend.</p></dd> - - -<dt>main</dt> -<dd><p>Title of the plot</p></dd> - -</dl></div> - <div id="details"> - <h2>Details</h2> - <p>Starting values of degradation model parameters and error model parameters -are shown as green circles. The results obtained in the original run -are shown as red circles.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Duchesne R, Guillemin A, Gandrillon O, Crauste F. Practical -identifiability in the frame of nonlinear mixed effects models: the example -of the in vitro erythropoiesis. BMC Bioinformatics. 2021 Oct 4;22(1):478. -doi: 10.1186/s12859-021-04373-4.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="multistart.html">multistart</a></p></div> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/plot.mixed.mmkin-1.png b/docs/dev/reference/plot.mixed.mmkin-1.png Binary files differdeleted file mode 100644 index 2e145bb7..00000000 --- a/docs/dev/reference/plot.mixed.mmkin-1.png +++ /dev/null diff --git a/docs/dev/reference/plot.mixed.mmkin-2.png 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href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mixed.mmkin.R" class="external-link"><code>R/plot.mixed.mmkin.R</code></a></small> - <div class="hidden name"><code>plot.mixed.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Plot predictions from a fitted nonlinear mixed model obtained via an mmkin row object</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mixed.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span></span> -<span> <span class="va">x</span>,</span> -<span> i <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/nrow.html" class="external-link">ncol</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">mmkin</span><span class="op">)</span>,</span> -<span> obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>,</span> -<span> standardized <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> covariates <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> covariate_quantiles <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.5</span>, <span class="fl">0.05</span>, <span class="fl">0.95</span><span class="op">)</span>,</span> -<span> xlab <span class="op">=</span> <span class="st">"Time"</span>,</span> -<span> xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/range.html" class="external-link">range</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span>,</span> -<span> resplot <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"predicted"</span>, <span class="st">"time"</span><span class="op">)</span>,</span> -<span> pop_curves <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> pred_over <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span> -<span> default_log_parms <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> ymax <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> maxabs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> ncol.legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op"><=</span> <span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">+</span> <span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op"><=</span> <span class="fl">8</span>, <span class="fl">3</span>, <span class="fl">4</span><span class="op">)</span><span class="op">)</span>,</span> -<span> nrow.legend <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Round.html" class="external-link">ceiling</a></span><span class="op">(</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">+</span> <span class="fl">1</span><span class="op">)</span><span class="op">/</span><span class="va">ncol.legend</span><span class="op">)</span>,</span> -<span> rel.height.legend <span class="op">=</span> <span class="fl">0.02</span> <span class="op">+</span> <span class="fl">0.07</span> <span class="op">*</span> <span class="va">nrow.legend</span>,</span> -<span> rel.height.bottom <span class="op">=</span> <span class="fl">1.1</span>,</span> -<span> pch_ds <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">i</span><span class="op">)</span>,</span> -<span> col_ds <span class="op">=</span> <span class="va">pch_ds</span> <span class="op">+</span> <span class="fl">1</span>,</span> -<span> lty_ds <span class="op">=</span> <span class="va">col_ds</span>,</span> -<span> frame <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An object of class <a href="mixed.html">mixed.mmkin</a>, <a href="saem.html">saem.mmkin</a> or <a href="nlme.mmkin.html">nlme.mmkin</a></p></dd> - - -<dt>i</dt> -<dd><p>A numeric index to select datasets for which to plot the individual predictions, -in case plots get too large</p></dd> - - -<dt>obs_vars</dt> -<dd><p>A character vector of names of the observed variables for -which the data and the model should be plotted. Defauls to all observed -variables in the model.</p></dd> - - -<dt>standardized</dt> -<dd><p>Should the residuals be standardized? Only takes effect if -<code>resplot = "time"</code>.</p></dd> - - -<dt>covariates</dt> -<dd><p>Data frame with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantiles'. -Each line in the data frame will result in a line drawn for the population. -Rownames are used in the legend to label the lines.</p></dd> - - -<dt>covariate_quantiles</dt> -<dd><p>This argument only has an effect if the fitted -object has covariate models. If so, the default is to show three population -curves, for the 5th percentile, the 50th percentile and the 95th percentile -of the covariate values used for fitting the model.</p></dd> - - -<dt>xlab</dt> -<dd><p>Label for the x axis.</p></dd> - - -<dt>xlim</dt> -<dd><p>Plot range in x direction.</p></dd> - - -<dt>resplot</dt> -<dd><p>Should the residuals plotted against time or against -predicted values?</p></dd> - - -<dt>pop_curves</dt> -<dd><p>Per default, one population curve is drawn in case -population parameters are fitted by the model, e.g. for saem objects. -In case there is a covariate model, the behaviour depends on the value -of 'covariates'</p></dd> - - -<dt>pred_over</dt> -<dd><p>Named list of alternative predictions as obtained -from <a href="mkinpredict.html">mkinpredict</a> with a compatible <a href="mkinmod.html">mkinmod</a>.</p></dd> - - -<dt>test_log_parms</dt> -<dd><p>Passed to <a href="mean_degparms.html">mean_degparms</a> in the case of an -<a href="mixed.html">mixed.mmkin</a> object</p></dd> - - -<dt>conf.level</dt> -<dd><p>Passed to <a href="mean_degparms.html">mean_degparms</a> in the case of an -<a href="mixed.html">mixed.mmkin</a> object</p></dd> - - -<dt>default_log_parms</dt> -<dd><p>Passed to <a href="mean_degparms.html">mean_degparms</a> in the case of an -<a href="mixed.html">mixed.mmkin</a> object</p></dd> - - -<dt>ymax</dt> -<dd><p>Vector of maximum y axis values</p></dd> - - -<dt>maxabs</dt> -<dd><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></dd> - - -<dt>ncol.legend</dt> -<dd><p>Number of columns to use in the legend</p></dd> - - -<dt>nrow.legend</dt> -<dd><p>Number of rows to use in the legend</p></dd> - - -<dt>rel.height.legend</dt> -<dd><p>The relative height of the legend shown on top</p></dd> - - -<dt>rel.height.bottom</dt> -<dd><p>The relative height of the bottom plot row</p></dd> - - -<dt>pch_ds</dt> -<dd><p>Symbols to be used for plotting the data.</p></dd> - - -<dt>col_ds</dt> -<dd><p>Colors used for plotting the observed data and the -corresponding model prediction lines for the different datasets.</p></dd> - - -<dt>lty_ds</dt> -<dd><p>Line types to be used for the model predictions.</p></dd> - - -<dt>frame</dt> -<dd><p>Should a frame be drawn around the plots?</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="note"> - <h2>Note</h2> - <p>Covariate models are currently only supported for saem.mmkin objects.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"ds "</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f</span><span class="op">[</span>, <span class="fl">3</span><span class="op">:</span><span class="fl">4</span><span class="op">]</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mixed.mmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># For this fit we need to increase pnlsMaxiter, and we increase the</span></span></span> -<span class="r-in"><span><span class="co"># tolerance in order to speed up the fit for this example evaluation</span></span></span> -<span class="r-in"><span><span class="co"># It still takes 20 seconds to run</span></span></span> -<span class="r-in"><span><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f</span>, control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>pnlsMaxIter <span class="op">=</span> <span class="fl">120</span>, tolerance <span class="op">=</span> <span class="fl">1e-3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlme</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mixed.mmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_saem</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f</span>, transformations <span class="op">=</span> <span class="st">"saemix"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mixed.mmkin-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_obs</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"obs"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_nlmix</span> <span class="op"><-</span> <span class="fu">nlmix</span><span class="op">(</span><span class="va">f_obs</span><span class="op">)</span></span></span> -<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in nlmix(f_obs):</span> could not find function "nlmix"</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_nlmix</span><span class="op">)</span></span></span> -<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in plot(f_nlmix):</span> object 'f_nlmix' not found</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># We can overlay the two variants if we generate predictions</span></span></span> -<span class="r-in"><span><span class="va">pred_nlme</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span></span> -<span class="r-in"><span> <span class="va">f_nlme</span><span class="op">$</span><span class="va">bparms.optim</span><span class="op">[</span><span class="op">-</span><span class="fl">1</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="va">f_nlme</span><span class="op">$</span><span class="va">bparms.optim</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>, A1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/seq.html" class="external-link">seq</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">180</span>, by <span class="op">=</span> <span class="fl">0.2</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem</span>, pred_over <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>nlme <span class="op">=</span> <span class="va">pred_nlme</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mixed.mmkin-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/plot.mkinfit-1.png b/docs/dev/reference/plot.mkinfit-1.png Binary files differdeleted file mode 100644 index a48ea72b..00000000 --- a/docs/dev/reference/plot.mkinfit-1.png +++ /dev/null diff --git a/docs/dev/reference/plot.mkinfit-2.png 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residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot the observed data and the fitted model of an mkinfit object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mkinfit.R" class="external-link"><code>R/plot.mkinfit.R</code></a></small> - <div class="hidden name"><code>plot.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Solves the differential equations with the optimised and fixed parameters -from a previous successful call to <code><a href="mkinfit.html">mkinfit</a></code> and plots the -observed data together with the solution of the fitted model.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span></span> -<span> <span class="va">x</span>,</span> -<span> fit <span class="op">=</span> <span class="va">x</span>,</span> -<span> obs_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">mkinmod</span><span class="op">$</span><span class="va">map</span><span class="op">)</span>,</span> -<span> xlab <span class="op">=</span> <span class="st">"Time"</span>,</span> -<span> ylab <span class="op">=</span> <span class="st">"Residue"</span>,</span> -<span> xlim <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/range.html" class="external-link">range</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">data</span><span class="op">$</span><span class="va">time</span><span class="op">)</span>,</span> -<span> ylim <span class="op">=</span> <span class="st">"default"</span>,</span> -<span> col_obs <span class="op">=</span> <span class="fl">1</span><span class="op">:</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">obs_vars</span><span class="op">)</span>,</span> -<span> pch_obs <span class="op">=</span> <span class="va">col_obs</span>,</span> -<span> lty_obs <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="va">obs_vars</span><span class="op">)</span><span class="op">)</span>,</span> -<span> add <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> legend <span class="op">=</span> <span class="op">!</span><span class="va">add</span>,</span> -<span> show_residuals <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> show_errplot <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> maxabs <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> sep_obs <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> rel.height.middle <span class="op">=</span> <span class="fl">0.9</span>,</span> -<span> row_layout <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> lpos <span class="op">=</span> <span class="st">"topright"</span>,</span> -<span> inset <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0.05</span>, <span class="fl">0.05</span><span class="op">)</span>,</span> -<span> show_errmin <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> errmin_digits <span class="op">=</span> <span class="fl">3</span>,</span> -<span> frame <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="fu">plot_sep</span><span class="op">(</span></span> -<span> <span class="va">fit</span>,</span> -<span> show_errmin <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> show_residuals <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">err_mod</span>, <span class="st">"const"</span><span class="op">)</span>, <span class="cn">TRUE</span>, <span class="st">"standardized"</span><span class="op">)</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="fu">plot_res</span><span class="op">(</span></span> -<span> <span class="va">fit</span>,</span> -<span> sep_obs <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> show_errmin <span class="op">=</span> <span class="va">sep_obs</span>,</span> -<span> standardized <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/ifelse.html" class="external-link">ifelse</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/identical.html" class="external-link">identical</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">err_mod</span>, <span class="st">"const"</span><span class="op">)</span>, <span class="cn">FALSE</span>, <span class="cn">TRUE</span><span class="op">)</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="fu">plot_err</span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">FALSE</span>, show_errmin <span class="op">=</span> <span class="va">sep_obs</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>Alias for fit introduced for compatibility with the generic S3 -method.</p></dd> - - -<dt>fit</dt> -<dd><p>An object of class <code><a href="mkinfit.html">mkinfit</a></code>.</p></dd> - - -<dt>obs_vars</dt> -<dd><p>A character vector of names of the observed variables for -which the data and the model should be plotted. Defauls to all observed -variables in the model.</p></dd> - - -<dt>xlab</dt> -<dd><p>Label for the x axis.</p></dd> - - -<dt>ylab</dt> -<dd><p>Label for the y axis.</p></dd> - - -<dt>xlim</dt> -<dd><p>Plot range in x direction.</p></dd> - - -<dt>ylim</dt> -<dd><p>Plot range in y direction. If given as a list, plot ranges -for the different plot rows can be given for row layout.</p></dd> - - -<dt>col_obs</dt> -<dd><p>Colors used for plotting the observed data and the -corresponding model prediction lines.</p></dd> - - -<dt>pch_obs</dt> -<dd><p>Symbols to be used for plotting the data.</p></dd> - - -<dt>lty_obs</dt> -<dd><p>Line types to be used for the model predictions.</p></dd> - - -<dt>add</dt> -<dd><p>Should the plot be added to an existing plot?</p></dd> - - -<dt>legend</dt> -<dd><p>Should a legend be added to the plot?</p></dd> - - -<dt>show_residuals</dt> -<dd><p>Should residuals be shown? If only one plot of the -fits is shown, the residual plot is in the lower third of the plot. -Otherwise, i.e. if "sep_obs" is given, the residual plots will be located -to the right of the plots of the fitted curves. If this is set to -'standardized', a plot of the residuals divided by the standard deviation -given by the fitted error model will be shown.</p></dd> - - -<dt>show_errplot</dt> -<dd><p>Should squared residuals and the error model be shown? -If only one plot of the fits is shown, this plot is in the lower third of -the plot. Otherwise, i.e. if "sep_obs" is given, the residual plots will -be located to the right of the plots of the fitted curves.</p></dd> - - -<dt>maxabs</dt> -<dd><p>Maximum absolute value of the residuals. This is used for the -scaling of the y axis and defaults to "auto".</p></dd> - - -<dt>sep_obs</dt> -<dd><p>Should the observed variables be shown in separate subplots? -If yes, residual plots requested by "show_residuals" will be shown next -to, not below the plot of the fits.</p></dd> - - -<dt>rel.height.middle</dt> -<dd><p>The relative height of the middle plot, if more -than two rows of plots are shown.</p></dd> - - -<dt>row_layout</dt> -<dd><p>Should we use a row layout where the residual plot or the -error model plot is shown to the right?</p></dd> - - -<dt>lpos</dt> -<dd><p>Position(s) of the legend(s). Passed to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code> as -the first argument. If not length one, this should be of the same length -as the obs_var argument.</p></dd> - - -<dt>inset</dt> -<dd><p>Passed to <code><a href="https://rdrr.io/r/graphics/legend.html" class="external-link">legend</a></code> if applicable.</p></dd> - - -<dt>show_errmin</dt> -<dd><p>Should the FOCUS chi2 error value be shown in the upper -margin of the plot?</p></dd> - - -<dt>errmin_digits</dt> -<dd><p>The number of significant digits for rounding the FOCUS -chi2 error percentage.</p></dd> - - -<dt>frame</dt> -<dd><p>Should a frame be drawn around the plots?</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to <code><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></code>.</p></dd> - - -<dt>standardized</dt> -<dd><p>When calling 'plot_res', should the residuals be -standardized in the residual plot?</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>If the current plot device is a <code><a href="https://rdrr.io/pkg/tikzDevice/man/tikz.html" class="external-link">tikz</a></code> device, then -latex is being used for the formatting of the chi2 error level, if -<code>show_errmin = TRUE</code>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># One parent compound, one metabolite, both single first order, path from</span></span></span> -<span class="r-in"><span><span class="co"># parent to sink included</span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"m1"</span>, full <span class="op">=</span> <span class="st">"Parent"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, full <span class="op">=</span> <span class="st">"Metabolite M1"</span> <span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_2006_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">plot_res</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">plot_res</span><span class="op">(</span><span class="va">fit</span>, standardized <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu">plot_err</span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Show the observed variables separately, with residuals</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_residuals <span class="op">=</span> <span class="cn">TRUE</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-5.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The same can be obtained with less typing, using the convenience function plot_sep</span></span></span> -<span class="r-in"><span><span class="fu">plot_sep</span><span class="op">(</span><span class="va">fit</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-6.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Show the observed variables separately, with the error model</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span>, sep_obs <span class="op">=</span> <span class="cn">TRUE</span>, show_errplot <span class="op">=</span> <span class="cn">TRUE</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> show_errmin <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mkinfit-7.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/plot.mmkin-1.png b/docs/dev/reference/plot.mmkin-1.png Binary files differdeleted file mode 100644 index c4fcb9ac..00000000 --- a/docs/dev/reference/plot.mmkin-1.png +++ /dev/null diff --git a/docs/dev/reference/plot.mmkin-2.png b/docs/dev/reference/plot.mmkin-2.png Binary files differdeleted file mode 100644 index 8cc727c3..00000000 --- a/docs/dev/reference/plot.mmkin-2.png +++ /dev/null diff --git a/docs/dev/reference/plot.mmkin-3.png b/docs/dev/reference/plot.mmkin-3.png Binary files differdeleted file mode 100644 index 066958c9..00000000 --- a/docs/dev/reference/plot.mmkin-3.png +++ /dev/null diff --git a/docs/dev/reference/plot.mmkin-4.png b/docs/dev/reference/plot.mmkin-4.png Binary files differdeleted file mode 100644 index c91410fa..00000000 --- a/docs/dev/reference/plot.mmkin-4.png +++ /dev/null diff 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an mmkin object ([.mmkin), the -same model fitted for at least one dataset is shown. When it is a column, -the fit of at least one model to the same dataset is shown."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot model fits (observed and fitted) and the residuals for a row or column -of an mmkin object</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/plot.mmkin.R" class="external-link"><code>R/plot.mmkin.R</code></a></small> - <div class="hidden name"><code>plot.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>When x is a row selected from an mmkin object (<code><a href="Extract.mmkin.html">[.mmkin</a></code>), the -same model fitted for at least one dataset is shown. When it is a column, -the fit of at least one model to the same dataset is shown.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span></span> -<span> <span class="va">x</span>,</span> -<span> main <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> legends <span class="op">=</span> <span class="fl">1</span>,</span> -<span> resplot <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"time"</span>, <span class="st">"errmod"</span><span class="op">)</span>,</span> -<span> ylab <span class="op">=</span> <span class="st">"Residue"</span>,</span> -<span> standardized <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> show_errmin <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> errmin_var <span class="op">=</span> <span class="st">"All data"</span>,</span> -<span> errmin_digits <span class="op">=</span> <span class="fl">3</span>,</span> -<span> cex <span class="op">=</span> <span class="fl">0.7</span>,</span> -<span> rel.height.middle <span class="op">=</span> <span class="fl">0.9</span>,</span> -<span> ymax <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An object of class <code><a href="mmkin.html">mmkin</a></code>, with either one row or one -column.</p></dd> - - -<dt>main</dt> -<dd><p>The main title placed on the outer margin of the plot.</p></dd> - - -<dt>legends</dt> -<dd><p>An index for the fits for which legends should be shown.</p></dd> - - -<dt>resplot</dt> -<dd><p>Should the residuals plotted against time, using -<code><a href="mkinresplot.html">mkinresplot</a></code>, or as squared residuals against predicted -values, with the error model, using <code><a href="mkinerrplot.html">mkinerrplot</a></code>.</p></dd> - - -<dt>ylab</dt> -<dd><p>Label for the y axis.</p></dd> - - -<dt>standardized</dt> -<dd><p>Should the residuals be standardized? This option -is passed to <code><a href="mkinresplot.html">mkinresplot</a></code>, it only takes effect if -<code>resplot = "time"</code>.</p></dd> - - -<dt>show_errmin</dt> -<dd><p>Should the chi2 error level be shown on top of the plots -to the left?</p></dd> - - -<dt>errmin_var</dt> -<dd><p>The variable for which the FOCUS chi2 error value should -be shown.</p></dd> - - -<dt>errmin_digits</dt> -<dd><p>The number of significant digits for rounding the FOCUS -chi2 error percentage.</p></dd> - - -<dt>cex</dt> -<dd><p>Passed to the plot functions and <code><a href="https://rdrr.io/r/graphics/mtext.html" class="external-link">mtext</a></code>.</p></dd> - - -<dt>rel.height.middle</dt> -<dd><p>The relative height of the middle plot, if more -than two rows of plots are shown.</p></dd> - - -<dt>ymax</dt> -<dd><p>Maximum y axis value for <code><a href="plot.mkinfit.html">plot.mkinfit</a></code>.</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to <code><a href="plot.mkinfit.html">plot.mkinfit</a></code> and -<code><a href="mkinresplot.html">mkinresplot</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>If the current plot device is a <code><a href="https://rdrr.io/pkg/tikzDevice/man/tikz.html" class="external-link">tikz</a></code> device, then -latex is being used for the formatting of the chi2 error level.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="co"># Only use one core not to offend CRAN checks</span></span></span> -<span class="r-in"><span> <span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"HS"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS B"</span> <span class="op">=</span> <span class="va">FOCUS_2006_B</span>, <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>, <span class="co"># named list for titles</span></span></span> -<span class="r-in"><span> cores <span class="op">=</span> <span class="fl">1</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Optimisation did not converge:</span> -<span class="r-wrn co"><span class="r-pr">#></span> iteration limit reached without convergence (10)</span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mmkin-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mmkin-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, show_errmin <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mmkin-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># We can also plot a single fit, if we like the way plot.mmkin works, but then the plot</span></span></span> -<span class="r-in"><span> <span class="co"># height should be smaller than the plot width (this is not possible for the html pages</span></span></span> -<span class="r-in"><span> <span class="co"># generated by pkgdown, as far as I know).</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="st">"FOCUS C"</span><span class="op">]</span><span class="op">)</span> <span class="co"># same as plot(fits[1, 2])</span></span></span> -<span class="r-plt img"><img src="plot.mmkin-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># Show the error models</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fits</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span>, resplot <span class="op">=</span> <span class="st">"errmod"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="plot.mmkin-5.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/plot.nafta.html b/docs/dev/reference/plot.nafta.html deleted file mode 100644 index 8acaa8b3..00000000 --- a/docs/dev/reference/plot.nafta.html +++ /dev/null @@ -1,175 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" 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residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Plot the results of the three models used in the NAFTA scheme.</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/nafta.R" class="external-link"><code>R/nafta.R</code></a></small> - <div class="hidden name"><code>plot.nafta.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The plots are ordered with increasing complexity of the model in this -function (SFO, then IORE, then DFOP).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for nafta</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">x</span>, legend <span class="op">=</span> <span class="cn">FALSE</span>, main <span class="op">=</span> <span class="st">"auto"</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>x</dt> -<dd><p>An object of class <code><a href="nafta.html">nafta</a></code>.</p></dd> - - -<dt>legend</dt> -<dd><p>Should a legend be added?</p></dd> - - -<dt>main</dt> -<dd><p>Possibility to override the main title of the plot.</p></dd> - - -<dt>...</dt> -<dd><p>Further arguments passed to <code><a href="plot.mmkin.html">plot.mmkin</a></code>.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The function is called for its side effect.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>Calls <code><a href="plot.mmkin.html">plot.mmkin</a></code>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/print.mmkin.html b/docs/dev/reference/print.mmkin.html deleted file mode 100644 index 12c67d86..00000000 --- a/docs/dev/reference/print.mmkin.html +++ /dev/null @@ -1,194 +0,0 @@ -<!-- Generated by pkgdown: do not edit by hand --> -<!DOCTYPE html> -<html lang="en"> - <head> - <meta charset="utf-8"> -<meta http-equiv="X-UA-Compatible" content="IE=edge"> -<meta name="viewport" content="width=device-width, initial-scale=1.0"> - -<title>Print method for mmkin objects — print.mmkin • mkin</title> - - -<!-- jquery --> -<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script> -<!-- Bootstrap --> - -<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" 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href='https://github.com/jranke/mkin/blob/master/R/mmkin.R'><code>R/mmkin.R</code></a></small> - <div class="hidden name"><code>print.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Print method for mmkin objects</p> - </div> - - <pre class="usage"><span class='co'># S3 method for mmkin</span> -<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>x</span>, <span class='va'>...</span><span class='op'>)</span></pre> - - <h2 class="hasAnchor" id="arguments"><a class="anchor" href="#arguments"></a>Arguments</h2> - <table class="ref-arguments"> - <colgroup><col class="name" /><col class="desc" /></colgroup> - <tr> - <th>x</th> - <td><p>An <a href='mmkin.html'>mmkin</a> object.</p></td> - </tr> - <tr> - <th>...</th> - <td><p>Not used.</p></td> - </tr> - </table> - - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"> - <h2 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property="og:description" content="This function imports one dataset from each sheet of a spreadsheet file. -These sheets are selected based on the contents of a sheet 'Datasets', with -a column called 'Dataset Number', containing numbers identifying the dataset -sheets to be read in. 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</li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Read datasets and relevant meta information from a spreadsheet file</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/read_spreadsheet.R" class="external-link"><code>R/read_spreadsheet.R</code></a></small> - <div class="hidden name"><code>read_spreadsheet.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function imports one dataset from each sheet of a spreadsheet file. -These sheets are selected based on the contents of a sheet 'Datasets', with -a column called 'Dataset Number', containing numbers identifying the dataset -sheets to be read in. In the second column there must be a grouping -variable, which will often be named 'Soil'. Optionally, time normalization -factors can be given in columns named 'Temperature' and 'Moisture'.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">read_spreadsheet</span><span class="op">(</span></span> -<span> <span class="va">path</span>,</span> -<span> valid_datasets <span class="op">=</span> <span class="st">"all"</span>,</span> -<span> parent_only <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> normalize <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>path</dt> -<dd><p>Absolute or relative path to the spreadsheet file</p></dd> - - -<dt>valid_datasets</dt> -<dd><p>Optional numeric index of the valid datasets, default is -to use all datasets</p></dd> - - -<dt>parent_only</dt> -<dd><p>Should only the parent data be used?</p></dd> - - -<dt>normalize</dt> -<dd><p>Should the time scale be normalized using temperature -and moisture normalisation factors in the sheet 'Datasets'?</p></dd> - -</dl></div> - <div id="details"> - <h2>Details</h2> - <p>There must be a sheet 'Compounds', with columns 'Name' and 'Acronym'. -The first row read after the header read in from this sheet is assumed -to contain name and acronym of the parent compound.</p> -<p>The dataset sheets should be named using the dataset numbers read in from -the 'Datasets' sheet, i.e. '1', '2', ... . In each dataset sheet, name -of the observed variable (e.g. the acronym of the parent compound or -one of its transformation products) should be in the first column, -the time values should be in the second colum, and the observed value -in the third column.</p> -<p>In case relevant covariate data are available, they should be given -in a sheet 'Covariates', containing one line for each value of the grouping -variable specified in 'Datasets'. These values should be in the first -column and the column must have the same name as the second column in -'Datasets'. Covariates will be read in from columns four and higher. -Their names should preferably not contain special characters like spaces, -so they can be easily used for specifying covariate models.</p> -<p>An similar data structure is defined as the R6 class <a href="mkindsg.html">mkindsg</a>, but -is probably more complicated to use.</p> - </div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/reexports.html b/docs/dev/reference/reexports.html deleted file mode 100644 index ee1148da..00000000 --- a/docs/dev/reference/reexports.html +++ /dev/null @@ -1,157 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Objects exported from other packages — reexports • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Objects exported from other packages — reexports"><meta property="og:description" content="These objects are imported from other packages. Follow the links -below to see their documentation. - - lmtest -lrtest - - - nlme -intervals, nlme - - -"><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - 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</li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Objects exported from other packages</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/intervals.R" class="external-link"><code>R/intervals.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/lrtest.mkinfit.R" class="external-link"><code>R/lrtest.mkinfit.R</code></a>, <a href="https://github.com/jranke/mkin/blob/HEAD/R/nlme.mmkin.R" class="external-link"><code>R/nlme.mmkin.R</code></a></small> - <div class="hidden name"><code>reexports.Rd</code></div> - </div> - - <div class="ref-description"> - <p>These objects are imported from other packages. Follow the links -below to see their documentation.</p> -<dl><dt>lmtest</dt> -<dd><p><code><a href="https://rdrr.io/pkg/lmtest/man/lrtest.html" class="external-link">lrtest</a></code></p></dd> - - - <dt>nlme</dt> -<dd><p><code><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></code>, <code><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></code></p></dd> - - -</dl></div> - - - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/residuals.mkinfit.html 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title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Extract residuals from an mkinfit model</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/residuals.mkinfit.R" class="external-link"><code>R/residuals.mkinfit.R</code></a></small> - <div class="hidden name"><code>residuals.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Extract residuals from an mkinfit model</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">object</span>, standardized <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>A <code><a href="mkinfit.html">mkinfit</a></code> object</p></dd> - - -<dt>standardized</dt> -<dd><p>Should the residuals be standardized by dividing by the -standard deviation obtained from the fitted error model?</p></dd> - - -<dt>...</dt> -<dd><p>Not used</p></dd> - -</dl></div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">f</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="va">FOCUS_2006_C</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">f</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.09726374 -0.13912142 -0.15351210 0.73388322 -0.08657004 -0.93204702</span> -<span class="r-out co"><span class="r-pr">#></span> [7] -0.03269080 1.45347823 -0.88423697</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/residuals.html" class="external-link">residuals</a></span><span class="op">(</span><span class="va">f</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.13969917 -0.19981904 -0.22048826 1.05407091 -0.12433989 -1.33869208</span> -<span class="r-out co"><span class="r-pr">#></span> [7] -0.04695355 2.08761977 -1.27002287</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - 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nonlinear mixed -effects models created from <a href="mmkin.html">mmkin</a> row objects using the Stochastic Approximation -Expectation Maximisation algorithm (SAEM).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">saem</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">saem</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> transformations <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"mkin"</span>, <span class="st">"saemix"</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> degparms_start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> test_log_parms <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> covariance.model <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> omega.init <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> covariates <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> covariate_models <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> error.init <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fl">1</span><span class="op">)</span>,</span> -<span> nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">300</span>, <span class="fl">100</span><span class="op">)</span>,</span> -<span> control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>displayProgress <span class="op">=</span> <span class="cn">FALSE</span>, print <span class="op">=</span> <span class="cn">FALSE</span>, nbiter.saemix <span class="op">=</span> <span class="va">nbiter.saemix</span>,</span> -<span> save <span class="op">=</span> <span class="cn">FALSE</span>, save.graphs <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> quiet <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">saemix_model</span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> solution_type <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> transformations <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"mkin"</span>, <span class="st">"saemix"</span><span class="op">)</span>,</span> -<span> error_model <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> degparms_start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> covariance.model <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> no_random_effect <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> omega.init <span class="op">=</span> <span class="st">"auto"</span>,</span> -<span> covariates <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> covariate_models <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> error.init <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">numeric</a></span><span class="op">(</span><span class="op">)</span>,</span> -<span> test_log_parms <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> conf.level <span class="op">=</span> <span class="fl">0.6</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="fu">saemix_data</span><span class="op">(</span><span class="va">object</span>, covariates <span class="op">=</span> <span class="cn">NULL</span>, verbose <span class="op">=</span> <span class="cn">FALSE</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An <a href="mmkin.html">mmkin</a> row object containing several fits of the same -<a href="mkinmod.html">mkinmod</a> model to different datasets</p></dd> - - -<dt>...</dt> -<dd><p>Further parameters passed to <a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel</a>.</p></dd> - - -<dt>transformations</dt> -<dd><p>Per default, all parameter transformations are done -in mkin. If this argument is set to 'saemix', parameter transformations -are done in 'saemix' for the supported cases, i.e. (as of version 1.1.2) -SFO, FOMC, DFOP and HS without fixing <code>parent_0</code>, and SFO or DFOP with -one SFO metabolite.</p></dd> - - -<dt>error_model</dt> -<dd><p>Possibility to override the error model used in the mmkin object</p></dd> - - -<dt>degparms_start</dt> -<dd><p>Parameter values given as a named numeric vector will -be used to override the starting values obtained from the 'mmkin' object.</p></dd> - - -<dt>test_log_parms</dt> -<dd><p>If TRUE, an attempt is made to use more robust starting -values for population parameters fitted as log parameters in mkin (like -rate constants) by only considering rate constants that pass the t-test -when calculating mean degradation parameters using <a href="mean_degparms.html">mean_degparms</a>.</p></dd> - - -<dt>conf.level</dt> -<dd><p>Possibility to adjust the required confidence level -for parameter that are tested if requested by 'test_log_parms'.</p></dd> - - -<dt>solution_type</dt> -<dd><p>Possibility to specify the solution type in case the -automatic choice is not desired</p></dd> - - -<dt>covariance.model</dt> -<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>. Per -default, uncorrelated random effects are specified for all degradation -parameters.</p></dd> - - -<dt>omega.init</dt> -<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>. If using -mkin transformations and the default covariance model with optionally -excluded random effects, the variances of the degradation parameters -are estimated using <a href="mean_degparms.html">mean_degparms</a>, with testing of untransformed -log parameters for significant difference from zero. If not using -mkin transformations or a custom covariance model, the default -initialisation of <a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel</a> is used for omega.init.</p></dd> - - -<dt>covariates</dt> -<dd><p>A data frame with covariate data for use in -'covariate_models', with dataset names as row names.</p></dd> - - -<dt>covariate_models</dt> -<dd><p>A list containing linear model formulas with one explanatory -variable, i.e. of the type 'parameter ~ covariate'. Covariates must be available -in the 'covariates' data frame.</p></dd> - - -<dt>no_random_effect</dt> -<dd><p>Character vector of degradation parameters for -which there should be no variability over the groups. Only used -if the covariance model is not explicitly specified.</p></dd> - - -<dt>error.init</dt> -<dd><p>Will be passed to <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code>.</p></dd> - - -<dt>nbiter.saemix</dt> -<dd><p>Convenience option to increase the number of -iterations</p></dd> - - -<dt>control</dt> -<dd><p>Passed to <a href="https://rdrr.io/pkg/saemix/man/saemix.html" class="external-link">saemix::saemix</a>.</p></dd> - - -<dt>verbose</dt> -<dd><p>Should we print information about created objects of -type <a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel</a> and <a href="https://rdrr.io/pkg/saemix/man/SaemixData-class.html" class="external-link">saemix::SaemixData</a>?</p></dd> - - -<dt>quiet</dt> -<dd><p>Should we suppress the messages saemix prints at the beginning -and the end of the optimisation process?</p></dd> - - -<dt>x</dt> -<dd><p>An saem.mmkin object to print</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An S3 object of class 'saem.mmkin', containing the fitted -<a href="https://rdrr.io/pkg/saemix/man/SaemixObject-class.html" class="external-link">saemix::SaemixObject</a> as a list component named 'so'. The -object also inherits from 'mixed.mmkin'.</p> - - -<p>An <a href="https://rdrr.io/pkg/saemix/man/SaemixModel-class.html" class="external-link">saemix::SaemixModel</a> object.</p> - - -<p>An <a href="https://rdrr.io/pkg/saemix/man/SaemixData-class.html" class="external-link">saemix::SaemixData</a> object.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>An mmkin row object is essentially a list of mkinfit objects that have been -obtained by fitting the same model to a list of datasets using <a href="mkinfit.html">mkinfit</a>.</p> -<p>Starting values for the fixed effects (population mean parameters, argument -psi0 of <code><a href="https://rdrr.io/pkg/saemix/man/saemixModel.html" class="external-link">saemix::saemixModel()</a></code> are the mean values of the parameters found -using <a href="mmkin.html">mmkin</a>.</p> - </div> - <div id="see-also"> - <h2>See also</h2> - <div class="dont-index"><p><a href="summary.saem.mmkin.html">summary.saem.mmkin</a> <a href="plot.mixed.mmkin.html">plot.mixed.mmkin</a></p></div> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">ds</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">experimental_data_for_UBA_2019</span><span class="op">[</span><span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">x</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">x</span><span class="op">$</span><span class="va">data</span><span class="op">[</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"name"</span>, <span class="st">"time"</span>, <span class="st">"value"</span><span class="op">)</span><span class="op">]</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"Dataset"</span>, <span class="fl">6</span><span class="op">:</span><span class="fl">10</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_mmkin_parent_p0_fixed</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="va">ds</span>,</span></span> -<span class="r-in"><span> state.ini <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>, fixed_initials <span class="op">=</span> <span class="st">"parent"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_p0_fixed</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent_p0_fixed</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_mmkin_parent</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span>, <span class="st">"DFOP"</span><span class="op">)</span>, <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_fomc</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_dfop</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent</span><span class="op">[</span><span class="st">"DFOP"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_sfo</span>, <span class="va">f_saem_fomc</span>, <span class="va">f_saem_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_sfo 5 624.33 622.38 -307.17</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_fomc 7 467.85 465.11 -226.92</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop 9 493.76 490.24 -237.88</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_sfo</span>, <span class="va">f_saem_dfop</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik Chisq Df Pr(>Chisq) </span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_sfo 5 624.33 622.38 -307.17 </span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop 9 493.76 490.24 -237.88 138.57 4 < 2.2e-16 ***</span> -<span class="r-out co"><span class="r-pr">#></span> ---</span> -<span class="r-out co"><span class="r-pr">#></span> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1</span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] "sd(g_qlogis)"</span> -<span class="r-in"><span><span class="va">f_saem_dfop_red</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_dfop</span>, no_random_effect <span class="op">=</span> <span class="st">"g_qlogis"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_dfop</span>, <span class="va">f_saem_dfop_red</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik Chisq Df Pr(>Chisq)</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop_red 8 488.68 485.55 -236.34 </span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop 9 493.76 490.24 -237.88 0 1 1</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_sfo</span>, <span class="va">f_saem_fomc</span>, <span class="va">f_saem_dfop</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_sfo 5 624.33 622.38 -307.17</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_fomc 7 467.85 465.11 -226.92</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop 9 493.76 490.24 -237.88</span> -<span class="r-in"><span><span class="co"># The returned saem.mmkin object contains an SaemixObject, therefore we can use</span></span></span> -<span class="r-in"><span><span class="co"># functions from saemix</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">saemix</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Loading required package: npde</span> -<span class="r-msg co"><span class="r-pr">#></span> Package saemix, version 3.2</span> -<span class="r-msg co"><span class="r-pr">#></span> please direct bugs, questions and feedback to emmanuelle.comets@inserm.fr</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> Attaching package: ‘saemix’</span> -<span class="r-msg co"><span class="r-pr">#></span> The following objects are masked from ‘package:npde’:</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> kurtosis, skewness</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/compare.saemix.html" class="external-link">compare.saemix</a></span><span class="op">(</span><span class="va">f_saem_sfo</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, <span class="va">f_saem_dfop</span><span class="op">$</span><span class="va">so</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Likelihoods calculated by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC</span> -<span class="r-out co"><span class="r-pr">#></span> 1 624.3316 622.3788</span> -<span class="r-out co"><span class="r-pr">#></span> 2 467.8472 465.1132</span> -<span class="r-out co"><span class="r-pr">#></span> 3 493.7592 490.2441</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"convergence"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="saem-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"individual.fit"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="saem-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"npde"</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Simulating data using nsim = 1000 simulated datasets</span> -<span class="r-out co"><span class="r-pr">#></span> Computing WRES and npde .</span> -<span class="r-msg co"><span class="r-pr">#></span> Please use npdeSaemix to obtain VPC and npde</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_fomc</span><span class="op">$</span><span class="va">so</span>, plot.type <span class="op">=</span> <span class="st">"vpc"</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="saem-3.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">f_mmkin_parent_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_mmkin_parent</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_fomc_tc</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin_parent_tc</span><span class="op">[</span><span class="st">"FOMC"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_fomc</span>, <span class="va">f_saem_fomc_tc</span>, test <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik Chisq Df Pr(>Chisq)</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_fomc 7 467.85 465.11 -226.92 </span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_fomc_tc 8 469.83 466.71 -226.92 0.015 1 0.9027</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">sfo_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">fomc_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"FOMC"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"A1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span><span class="co"># The following fit uses analytical solutions for SFO-SFO and DFOP-SFO,</span></span></span> -<span class="r-in"><span><span class="co"># and compiled ODEs for FOMC that are much slower</span></span></span> -<span class="r-in"><span><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="st">"SFO-SFO"</span> <span class="op">=</span> <span class="va">sfo_sfo</span>, <span class="st">"FOMC-SFO"</span> <span class="op">=</span> <span class="va">fomc_sfo</span>, <span class="st">"DFOP-SFO"</span> <span class="op">=</span> <span class="va">dfop_sfo</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">ds</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># saem fits of SFO-SFO and DFOP-SFO to these data take about five seconds</span></span></span> -<span class="r-in"><span><span class="co"># each on this system, as we use analytical solutions written for saemix.</span></span></span> -<span class="r-in"><span><span class="co"># When using the analytical solutions written for mkin this took around</span></span></span> -<span class="r-in"><span><span class="co"># four minutes</span></span></span> -<span class="r-in"><span><span class="va">f_saem_sfo_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">[</span><span class="st">"SFO-SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_dfop_sfo</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># We can use print, plot and summary methods to check the results</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by SAEM</span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + f_parent_to_A1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> -<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_A1 * A1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood computed by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 839.2 834.1 -406.6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> estimate lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 93.70402 91.04104 96.3670</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 -5.83760 -7.66452 -4.0107</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.95718 -1.35955 -0.5548</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.35514 -3.39402 -1.3163</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 -3.79634 -5.64009 -1.9526</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.02108 -0.66463 0.6225</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 1.88191 1.66491 2.0989</span> -<span class="r-out co"><span class="r-pr">#></span> SD.parent_0 2.81628 0.78922 4.8433</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_A1 1.78751 0.42105 3.1540</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.45016 0.16116 0.7391</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 1.06923 0.31676 1.8217</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 2.03768 0.70938 3.3660</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.44024 -0.09262 0.9731</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="saem-4.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> saemix version used for fitting: 3.2 </span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:32:32 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:32:32 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_A1/dt = + f_parent_to_A1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> -<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_A1 * A1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 170 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 4.145 s</span> -<span class="r-out co"><span class="r-pr">#></span> Using 300, 100 iterations and 10 chains</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model: Constant variance </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for degradation parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_A1 f_parent_qlogis log_k1 log_k2 </span> -<span class="r-out co"><span class="r-pr">#></span> 93.8102 -5.3734 -0.9711 -1.8799 -4.2708 </span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> -<span class="r-out co"><span class="r-pr">#></span> 0.1356 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for random effects (square root of initial entries in omega):</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_A1 f_parent_qlogis log_k1 log_k2 g_qlogis</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 4.941 0.000 0.0000 0.000 0.000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 0.000 2.551 0.0000 0.000 0.000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000 0.000 0.7251 0.000 0.000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 0.000 0.000 0.0000 1.449 0.000 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 0.000 0.000 0.0000 0.000 2.228 0.0000</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis 0.000 0.000 0.0000 0.000 0.000 0.7814</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for error model parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 </span> -<span class="r-out co"><span class="r-pr">#></span> 1 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood computed by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 839.2 834.1 -406.6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 93.70402 91.04104 96.3670</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 -5.83760 -7.66452 -4.0107</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.95718 -1.35955 -0.5548</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.35514 -3.39402 -1.3163</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 -3.79634 -5.64009 -1.9526</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.02108 -0.66463 0.6225</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 1.88191 1.66491 2.0989</span> -<span class="r-out co"><span class="r-pr">#></span> SD.parent_0 2.81628 0.78922 4.8433</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_A1 1.78751 0.42105 3.1540</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.45016 0.16116 0.7391</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 1.06923 0.31676 1.8217</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 2.03768 0.70938 3.3660</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.44024 -0.09262 0.9731</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> parnt_0 lg_k_A1 f_prnt_ log_k1 log_k2 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k_A1 -0.0147 </span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.0269 0.0573 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 0.0263 -0.0011 -0.0040 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 0.0020 0.0065 -0.0002 -0.0776 </span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.0248 -0.0180 -0.0004 -0.0903 -0.0603</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> SD.parent_0 2.8163 0.78922 4.8433</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_A1 1.7875 0.42105 3.1540</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.4502 0.16116 0.7391</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 1.0692 0.31676 1.8217</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 2.0377 0.70938 3.3660</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.4402 -0.09262 0.9731</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 1.882 1.665 2.099</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 93.704015 9.104e+01 96.36699</span> -<span class="r-out co"><span class="r-pr">#></span> k_A1 0.002916 4.692e-04 0.01812</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_A1 0.277443 2.043e-01 0.36475</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.094880 3.357e-02 0.26813</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.022453 3.553e-03 0.14191</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.494731 3.397e-01 0.65078</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_A1 0.2774</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.7226</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 14.0 72.38 21.79 7.306 30.87</span> -<span class="r-out co"><span class="r-pr">#></span> A1 237.7 789.68 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> ds name time observed predicted residual std standardized</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 0 97.2 95.70025 1.49975 1.882 0.79693</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 0 96.4 95.70025 0.69975 1.882 0.37183</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 3 71.1 71.44670 -0.34670 1.882 -0.18423</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 3 69.2 71.44670 -2.24670 1.882 -1.19384</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 6 58.1 56.59283 1.50717 1.882 0.80087</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 6 56.6 56.59283 0.00717 1.882 0.00381</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 10 44.4 44.56648 -0.16648 1.882 -0.08847</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 10 43.4 44.56648 -1.16648 1.882 -0.61984</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 20 33.3 29.76020 3.53980 1.882 1.88096</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 20 29.2 29.76020 -0.56020 1.882 -0.29767</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 34 17.6 19.39208 -1.79208 1.882 -0.95226</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 34 18.0 19.39208 -1.39208 1.882 -0.73971</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 55 10.5 10.55761 -0.05761 1.882 -0.03061</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 55 9.3 10.55761 -1.25761 1.882 -0.66826</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 90 4.5 3.84742 0.65258 1.882 0.34676</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 90 4.7 3.84742 0.85258 1.882 0.45304</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 112 3.0 2.03997 0.96003 1.882 0.51013</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 112 3.4 2.03997 1.36003 1.882 0.72268</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 132 2.3 1.14585 1.15415 1.882 0.61328</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 parent 132 2.7 1.14585 1.55415 1.882 0.82583</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 3 4.3 4.86054 -0.56054 1.882 -0.29786</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 3 4.6 4.86054 -0.26054 1.882 -0.13844</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 6 7.0 7.74179 -0.74179 1.882 -0.39417</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 6 7.2 7.74179 -0.54179 1.882 -0.28789</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 10 8.2 9.94048 -1.74048 1.882 -0.92485</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 10 8.0 9.94048 -1.94048 1.882 -1.03112</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 20 11.0 12.19109 -1.19109 1.882 -0.63291</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 20 13.7 12.19109 1.50891 1.882 0.80180</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 34 11.5 13.10706 -1.60706 1.882 -0.85395</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 34 12.7 13.10706 -0.40706 1.882 -0.21630</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 55 14.9 13.06131 1.83869 1.882 0.97703</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 55 14.5 13.06131 1.43869 1.882 0.76448</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 90 12.1 11.54495 0.55505 1.882 0.29494</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 90 12.3 11.54495 0.75505 1.882 0.40122</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 112 9.9 10.31533 -0.41533 1.882 -0.22070</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 112 10.2 10.31533 -0.11533 1.882 -0.06128</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 132 8.8 9.20222 -0.40222 1.882 -0.21373</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 6 A1 132 7.8 9.20222 -1.40222 1.882 -0.74510</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 0 93.6 90.82357 2.77643 1.882 1.47532</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 0 92.3 90.82357 1.47643 1.882 0.78453</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 3 87.0 84.73448 2.26552 1.882 1.20384</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 3 82.2 84.73448 -2.53448 1.882 -1.34675</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 7 74.0 77.65013 -3.65013 1.882 -1.93958</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 7 73.9 77.65013 -3.75013 1.882 -1.99272</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 14 64.2 67.60639 -3.40639 1.882 -1.81007</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 14 69.5 67.60639 1.89361 1.882 1.00621</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 30 54.0 52.53663 1.46337 1.882 0.77760</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 30 54.6 52.53663 2.06337 1.882 1.09642</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 60 41.1 39.42728 1.67272 1.882 0.88884</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 60 38.4 39.42728 -1.02728 1.882 -0.54587</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 90 32.5 33.76360 -1.26360 1.882 -0.67144</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 90 35.5 33.76360 1.73640 1.882 0.92268</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 120 28.1 30.39975 -2.29975 1.882 -1.22203</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 120 29.0 30.39975 -1.39975 1.882 -0.74379</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 180 26.5 25.62379 0.87621 1.882 0.46559</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 parent 180 27.6 25.62379 1.97621 1.882 1.05010</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 3 3.9 2.70005 1.19995 1.882 0.63762</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 3 3.1 2.70005 0.39995 1.882 0.21252</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 7 6.9 5.83475 1.06525 1.882 0.56605</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 7 6.6 5.83475 0.76525 1.882 0.40663</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 14 10.4 10.26142 0.13858 1.882 0.07364</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 14 8.3 10.26142 -1.96142 1.882 -1.04225</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 30 14.4 16.82999 -2.42999 1.882 -1.29123</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 30 13.7 16.82999 -3.12999 1.882 -1.66319</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 60 22.1 22.32486 -0.22486 1.882 -0.11949</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 60 22.3 22.32486 -0.02486 1.882 -0.01321</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 90 27.5 24.45927 3.04073 1.882 1.61576</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 90 25.4 24.45927 0.94073 1.882 0.49988</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 120 28.0 25.54862 2.45138 1.882 1.30260</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 120 26.6 25.54862 1.05138 1.882 0.55868</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 180 25.8 26.82277 -1.02277 1.882 -0.54347</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 7 A1 180 25.3 26.82277 -1.52277 1.882 -0.80916</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 0 91.9 91.16791 0.73209 1.882 0.38901</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 0 90.8 91.16791 -0.36791 1.882 -0.19550</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 1 64.9 67.58358 -2.68358 1.882 -1.42598</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 1 66.2 67.58358 -1.38358 1.882 -0.73520</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 3 43.5 41.62086 1.87914 1.882 0.99853</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 3 44.1 41.62086 2.47914 1.882 1.31735</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 8 18.3 19.60116 -1.30116 1.882 -0.69140</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 8 18.1 19.60116 -1.50116 1.882 -0.79768</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 14 10.2 10.63101 -0.43101 1.882 -0.22903</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 14 10.8 10.63101 0.16899 1.882 0.08980</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 27 4.9 3.12435 1.77565 1.882 0.94354</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 27 3.3 3.12435 0.17565 1.882 0.09334</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 48 1.6 0.43578 1.16422 1.882 0.61864</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 48 1.5 0.43578 1.06422 1.882 0.56550</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 70 1.1 0.05534 1.04466 1.882 0.55510</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 parent 70 0.9 0.05534 0.84466 1.882 0.44883</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 1 9.6 7.63450 1.96550 1.882 1.04442</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 1 7.7 7.63450 0.06550 1.882 0.03481</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 3 15.0 15.52593 -0.52593 1.882 -0.27947</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 3 15.1 15.52593 -0.42593 1.882 -0.22633</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 8 21.2 20.32192 0.87808 1.882 0.46659</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 8 21.1 20.32192 0.77808 1.882 0.41345</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 14 19.7 20.09721 -0.39721 1.882 -0.21107</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 14 18.9 20.09721 -1.19721 1.882 -0.63617</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 27 17.5 16.37477 1.12523 1.882 0.59792</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 27 15.9 16.37477 -0.47477 1.882 -0.25228</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 48 9.5 10.13141 -0.63141 1.882 -0.33551</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 48 9.8 10.13141 -0.33141 1.882 -0.17610</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 70 6.2 5.81827 0.38173 1.882 0.20284</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 8 A1 70 6.1 5.81827 0.28173 1.882 0.14970</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 0 99.8 97.48728 2.31272 1.882 1.22892</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 0 98.3 97.48728 0.81272 1.882 0.43186</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 1 77.1 79.29476 -2.19476 1.882 -1.16624</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 1 77.2 79.29476 -2.09476 1.882 -1.11310</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 3 59.0 55.67060 3.32940 1.882 1.76915</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 3 58.1 55.67060 2.42940 1.882 1.29092</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 8 27.4 31.57871 -4.17871 1.882 -2.22046</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 8 29.2 31.57871 -2.37871 1.882 -1.26398</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 14 19.1 22.51546 -3.41546 1.882 -1.81489</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 14 29.6 22.51546 7.08454 1.882 3.76454</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 27 10.1 14.09074 -3.99074 1.882 -2.12057</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 27 18.2 14.09074 4.10926 1.882 2.18355</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 48 4.5 6.95747 -2.45747 1.882 -1.30584</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 48 9.1 6.95747 2.14253 1.882 1.13848</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 70 2.3 3.32472 -1.02472 1.882 -0.54451</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 70 2.9 3.32472 -0.42472 1.882 -0.22569</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 91 2.0 1.64300 0.35700 1.882 0.18970</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 91 1.8 1.64300 0.15700 1.882 0.08343</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 120 2.0 0.62073 1.37927 1.882 0.73291</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 parent 120 2.2 0.62073 1.57927 1.882 0.83918</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 1 4.2 3.64568 0.55432 1.882 0.29455</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 1 3.9 3.64568 0.25432 1.882 0.13514</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 3 7.4 8.30173 -0.90173 1.882 -0.47916</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 3 7.9 8.30173 -0.40173 1.882 -0.21347</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 8 14.5 12.71589 1.78411 1.882 0.94803</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 8 13.7 12.71589 0.98411 1.882 0.52293</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 14 14.2 13.90452 0.29548 1.882 0.15701</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 14 12.2 13.90452 -1.70452 1.882 -0.90574</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 27 13.7 14.15523 -0.45523 1.882 -0.24190</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 27 13.2 14.15523 -0.95523 1.882 -0.50759</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 48 13.6 13.31038 0.28962 1.882 0.15389</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 48 15.4 13.31038 2.08962 1.882 1.11037</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 70 10.4 11.85965 -1.45965 1.882 -0.77562</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 70 11.6 11.85965 -0.25965 1.882 -0.13797</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 91 10.0 10.36294 -0.36294 1.882 -0.19286</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 91 9.5 10.36294 -0.86294 1.882 -0.45855</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 120 9.1 8.43003 0.66997 1.882 0.35601</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 9 A1 120 9.0 8.43003 0.56997 1.882 0.30287</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 0 96.1 93.95603 2.14397 1.882 1.13925</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 0 94.3 93.95603 0.34397 1.882 0.18278</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 8 73.9 77.70592 -3.80592 1.882 -2.02237</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 8 73.9 77.70592 -3.80592 1.882 -2.02237</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 14 69.4 70.04570 -0.64570 1.882 -0.34311</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 14 73.1 70.04570 3.05430 1.882 1.62298</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 21 65.6 64.01710 1.58290 1.882 0.84111</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 21 65.3 64.01710 1.28290 1.882 0.68170</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 41 55.9 54.98434 0.91566 1.882 0.48656</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 41 54.4 54.98434 -0.58434 1.882 -0.31050</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 63 47.0 49.87137 -2.87137 1.882 -1.52577</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 63 49.3 49.87137 -0.57137 1.882 -0.30361</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 91 44.7 45.06727 -0.36727 1.882 -0.19516</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 91 46.7 45.06727 1.63273 1.882 0.86759</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 120 42.1 40.76402 1.33598 1.882 0.70991</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 parent 120 41.3 40.76402 0.53598 1.882 0.28481</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 8 3.3 4.14599 -0.84599 1.882 -0.44954</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 8 3.4 4.14599 -0.74599 1.882 -0.39640</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 14 3.9 6.08478 -2.18478 1.882 -1.16093</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 14 2.9 6.08478 -3.18478 1.882 -1.69231</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 21 6.4 7.59411 -1.19411 1.882 -0.63452</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 21 7.2 7.59411 -0.39411 1.882 -0.20942</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 41 9.1 9.78292 -0.68292 1.882 -0.36289</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 41 8.5 9.78292 -1.28292 1.882 -0.68171</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 63 11.7 10.93274 0.76726 1.882 0.40770</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 63 12.0 10.93274 1.06726 1.882 0.56711</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 91 13.3 11.93986 1.36014 1.882 0.72274</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 91 13.2 11.93986 1.26014 1.882 0.66961</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 120 14.3 12.79238 1.50762 1.882 0.80111</span> -<span class="r-out co"><span class="r-pr">#></span> Dataset 10 A1 120 12.1 12.79238 -0.69238 1.882 -0.36791</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The following takes about 6 minutes</span></span></span> -<span class="r-in"><span><span class="va">f_saem_dfop_sfo_deSolve</span> <span class="op"><-</span> <span class="fu">saem</span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">[</span><span class="st">"DFOP-SFO"</span>, <span class="op">]</span>, solution_type <span class="op">=</span> <span class="st">"deSolve"</span>,</span></span> -<span class="r-in"><span> nbiter.saemix <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">200</span>, <span class="fl">80</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> DINTDY- T (=R1) illegal </span> -<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 70</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> T not in interval TCUR - HU (= R1) to TCUR (=R2) </span> -<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 53.1122, R2 = 56.6407</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> DINTDY- T (=R1) illegal </span> -<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 91</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> T not in interval TCUR - HU (= R1) to TCUR (=R2) </span> -<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 53.1122, R2 = 56.6407</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> DLSODA- Trouble in DINTDY. ITASK = I1, TOUT = R1</span> -<span class="r-out co"><span class="r-pr">#></span> In above message, I1 = 1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> In above message, R1 = 91</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error in deSolve::lsoda(y = odeini, times = outtimes, func = lsoda_func, : </span> -<span class="r-out co"><span class="r-pr">#></span> illegal input detected before taking any integration steps - see written message</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co">#anova(</span></span></span> -<span class="r-in"><span><span class="co"># f_saem_dfop_sfo,</span></span></span> -<span class="r-in"><span><span class="co"># f_saem_dfop_sfo_deSolve))</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># If the model supports it, we can also use eigenvalue based solutions, which</span></span></span> -<span class="r-in"><span><span class="co"># take a similar amount of time</span></span></span> -<span class="r-in"><span><span class="co">#f_saem_sfo_sfo_eigen <- saem(f_mmkin["SFO-SFO", ], solution_type = "eigen",</span></span></span> -<span class="r-in"><span><span class="co"># control = list(nbiter.saemix = c(200, 80), nbdisplay = 10))</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/schaefer07_complex_case-1.png b/docs/dev/reference/schaefer07_complex_case-1.png Binary files differdeleted file mode 100644 index 7622ae7f..00000000 --- a/docs/dev/reference/schaefer07_complex_case-1.png +++ /dev/null diff --git a/docs/dev/reference/schaefer07_complex_case.html b/docs/dev/reference/schaefer07_complex_case.html deleted file mode 100644 index 880e5ac0..00000000 --- a/docs/dev/reference/schaefer07_complex_case.html +++ /dev/null @@ -1,221 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Metabolism data set used for checking the software quality of KinGUI — schaefer07_complex_case • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Metabolism data set used for checking the software quality of KinGUI — schaefer07_complex_case"><meta property="og:description" content="This dataset was used for a comparison of KinGUI and ModelMaker to check the - 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<span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Metabolism data set used for checking the software quality of KinGUI</h1> - - <div class="hidden name"><code>schaefer07_complex_case.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This dataset was used for a comparison of KinGUI and ModelMaker to check the - software quality of KinGUI in the original publication (Schäfer et al., 2007). - The results from the fitting are also included.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">schaefer07_complex_case</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>The data set is a data frame with 8 observations on the following 6 variables.</p><dl><dt><code>time</code></dt> -<dd><p>a numeric vector</p></dd> - - <dt><code>parent</code></dt> -<dd><p>a numeric vector</p></dd> - - <dt><code>A1</code></dt> -<dd><p>a numeric vector</p></dd> - - <dt><code>B1</code></dt> -<dd><p>a numeric vector</p></dd> - - <dt><code>C1</code></dt> -<dd><p>a numeric vector</p></dd> - - <dt><code>A2</code></dt> -<dd><p>a numeric vector</p></dd> - - -</dl><p>The results are a data frame with 14 results for different parameter values</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Schäfer D, Mikolasch B, Rainbird P and Harvey B (2007). KinGUI: a new kinetic - software tool for evaluations according to FOCUS degradation kinetics. In: Del - Re AAM, Capri E, Fragoulis G and Trevisan M (Eds.). Proceedings of the XIII - Symposium Pesticide Chemistry, Piacenza, 2007, p. 916-923.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">data</span> <span class="op"><-</span> <span class="fu"><a href="mkin_wide_to_long.html">mkin_wide_to_long</a></span><span class="op">(</span><span class="va">schaefer07_complex_case</span>, time <span class="op">=</span> <span class="st">"time"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">model</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"A1"</span>, <span class="st">"B1"</span>, <span class="st">"C1"</span><span class="op">)</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"A2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> B1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> C1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> A2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">model</span>, <span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="schaefer07_complex_case-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="endpoints.html">endpoints</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> $ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_A1 parent_B1 parent_C1 parent_sink A1_A2 A1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 0.3809620 0.1954667 0.4235713 0.0000000 0.4479619 0.5520381 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> $distimes</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 13.95078 46.34350</span> -<span class="r-out co"><span class="r-pr">#></span> A1 49.75342 165.27728</span> -<span class="r-out co"><span class="r-pr">#></span> B1 37.26908 123.80520</span> -<span class="r-out co"><span class="r-pr">#></span> C1 11.23131 37.30961</span> -<span class="r-out co"><span class="r-pr">#></span> A2 28.50624 94.69567</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -<span class="r-in"><span> <span class="co"># Compare with the results obtained in the original publication</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">schaefer07_complex_results</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> compound parameter KinGUI ModelMaker deviation</span> -<span class="r-out co"><span class="r-pr">#></span> 1 parent degradation rate 0.0496 0.0506 2.0</span> -<span class="r-out co"><span class="r-pr">#></span> 2 parent DT50 13.9900 13.6900 2.2</span> -<span class="r-out co"><span class="r-pr">#></span> 3 metabolite A1 formation fraction 0.3803 0.3696 2.9</span> -<span class="r-out co"><span class="r-pr">#></span> 4 metabolite A1 degradation rate 0.0139 0.0136 2.2</span> -<span class="r-out co"><span class="r-pr">#></span> 5 metabolite A1 DT50 49.9600 50.8900 1.8</span> -<span class="r-out co"><span class="r-pr">#></span> 6 metabolite B1 formation fraction 0.1866 0.1818 2.6</span> -<span class="r-out co"><span class="r-pr">#></span> 7 metabolite B1 degradation rate 0.0175 0.0172 1.7</span> -<span class="r-out co"><span class="r-pr">#></span> 8 metabolite B1 DT50 39.6100 40.2400 1.6</span> -<span class="r-out co"><span class="r-pr">#></span> 9 metabolite C1 formation fraction 0.4331 0.4486 3.5</span> -<span class="r-out co"><span class="r-pr">#></span> 10 metabolite C1 degradation rate 0.0638 0.0700 8.9</span> -<span class="r-out co"><span class="r-pr">#></span> 11 metabolite C1 DT50 10.8700 9.9000 9.8</span> -<span class="r-out co"><span class="r-pr">#></span> 12 metabolite A2 formation fraction 0.4529 0.4559 0.7</span> -<span class="r-out co"><span class="r-pr">#></span> 13 metabolite A2 degradation rate 0.0245 0.0244 0.4</span> -<span class="r-out co"><span class="r-pr">#></span> 14 metabolite A2 DT50 28.2400 28.4500 0.7</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/set_nd_nq.html b/docs/dev/reference/set_nd_nq.html deleted file mode 100644 index 6f4ae169..00000000 --- a/docs/dev/reference/set_nd_nq.html +++ /dev/null @@ -1,278 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Set non-detects and unquantified values in residue series without replicates — set_nd_nq • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" 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--><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Set non-detects and unquantified values in residue series without replicates — set_nd_nq"><meta property="og:description" content="This function automates replacing unquantified values in residue time and -depth series. For time series, the function performs part of the residue -processing proposed in the FOCUS kinetics guidance for parent compounds -and metabolites. For two-dimensional residue series over time and depth, -it automates the proposal of Boesten et al (2015)."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Set non-detects and unquantified values in residue series without replicates</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/set_nd_nq.R" class="external-link"><code>R/set_nd_nq.R</code></a></small> - <div class="hidden name"><code>set_nd_nq.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function automates replacing unquantified values in residue time and -depth series. For time series, the function performs part of the residue -processing proposed in the FOCUS kinetics guidance for parent compounds -and metabolites. For two-dimensional residue series over time and depth, -it automates the proposal of Boesten et al (2015).</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">res_raw</span>, <span class="va">lod</span>, loq <span class="op">=</span> <span class="cn">NA</span>, time_zero_presence <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">set_nd_nq_focus</span><span class="op">(</span></span> -<span> <span class="va">res_raw</span>,</span> -<span> <span class="va">lod</span>,</span> -<span> loq <span class="op">=</span> <span class="cn">NA</span>,</span> -<span> set_first_sample_nd <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> first_sample_nd_value <span class="op">=</span> <span class="fl">0</span>,</span> -<span> ignore_below_loq_after_first_nd <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>res_raw</dt> -<dd><p>Character vector of a residue time series, or matrix of -residue values with rows representing depth profiles for a specific sampling -time, and columns representing time series of residues at the same depth. -Values below the limit of detection (lod) have to be coded as "nd", values -between the limit of detection and the limit of quantification, if any, have -to be coded as "nq". Samples not analysed have to be coded as "na". All -values that are not "na", "nd" or "nq" have to be coercible to numeric</p></dd> - - -<dt>lod</dt> -<dd><p>Limit of detection (numeric)</p></dd> - - -<dt>loq</dt> -<dd><p>Limit of quantification(numeric). Must be specified if the FOCUS rule to -stop after the first non-detection is to be applied</p></dd> - - -<dt>time_zero_presence</dt> -<dd><p>Do we assume that residues occur at time zero? -This only affects samples from the first sampling time that have been -reported as "nd" (not detected).</p></dd> - - -<dt>set_first_sample_nd</dt> -<dd><p>Should the first sample be set to "first_sample_nd_value" -in case it is a non-detection?</p></dd> - - -<dt>first_sample_nd_value</dt> -<dd><p>Value to be used for the first sample if it is a non-detection</p></dd> - - -<dt>ignore_below_loq_after_first_nd</dt> -<dd><p>Should we ignore values below the LOQ after the first -non-detection that occurs after the quantified values?</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A numeric vector, if a vector was supplied, or a numeric matrix otherwise</p> - </div> - <div id="functions"> - <h2>Functions</h2> - -<ul><li><p><code>set_nd_nq_focus()</code>: Set non-detects in residue time series according to FOCUS rules</p></li> -</ul></div> - <div id="references"> - <h2>References</h2> - <p>Boesten, J. J. T. I., van der Linden, A. M. A., Beltman, W. H. -J. and Pol, J. W. (2015). Leaching of plant protection products and their -transformation products; Proposals for improving the assessment of leaching -to groundwater in the Netherlands — Version 2. Alterra report 2630, Alterra -Wageningen UR (University & Research centre)</p> -<p>FOCUS (2014) Generic Guidance for Estimating Persistence and Degradation -Kinetics from Environmental Fate Studies on Pesticides in EU Registration, Version 1.1, -18 December 2014, p. 251</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># FOCUS (2014) p. 75/76 and 131/132</span></span></span> -<span class="r-in"><span><span class="va">parent_1</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">.12</span>, <span class="fl">.09</span>, <span class="fl">.05</span>, <span class="fl">.03</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">parent_1</span>, <span class="fl">0.02</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.12 0.09 0.05 0.03 0.01 NA NA NA NA NA</span> -<span class="r-in"><span><span class="va">parent_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">.12</span>, <span class="fl">.09</span>, <span class="fl">.05</span>, <span class="fl">.03</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="fl">.03</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">parent_2</span>, <span class="fl">0.02</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.03 0.01 NA NA</span> -<span class="r-in"><span><span class="fu">set_nd_nq_focus</span><span class="op">(</span><span class="va">parent_2</span>, <span class="fl">0.02</span>, loq <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.12 0.09 0.05 0.03 0.01 NA NA NA NA NA</span> -<span class="r-in"><span><span class="va">parent_3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">.12</span>, <span class="fl">.09</span>, <span class="fl">.05</span>, <span class="fl">.03</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="fl">.06</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">parent_3</span>, <span class="fl">0.02</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.06 0.01 NA NA</span> -<span class="r-in"><span><span class="fu">set_nd_nq_focus</span><span class="op">(</span><span class="va">parent_3</span>, <span class="fl">0.02</span>, loq <span class="op">=</span> <span class="fl">0.05</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.12 0.09 0.05 0.03 0.01 0.01 0.06 0.01 NA NA</span> -<span class="r-in"><span><span class="va">metabolite</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>, <span class="fl">0.03</span>, <span class="fl">0.06</span>, <span class="fl">0.10</span>, <span class="fl">0.11</span>, <span class="fl">0.10</span>, <span class="fl">0.09</span>, <span class="fl">0.05</span>, <span class="fl">0.03</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">metabolite</span>, <span class="fl">0.02</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] NA NA 0.01 0.03 0.06 0.10 0.11 0.10 0.09 0.05 0.03 0.01 NA</span> -<span class="r-in"><span><span class="fu">set_nd_nq_focus</span><span class="op">(</span><span class="va">metabolite</span>, <span class="fl">0.02</span>, <span class="fl">0.05</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.00 NA 0.01 0.03 0.06 0.10 0.11 0.10 0.09 0.05 0.03 0.01 NA</span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># Boesten et al. (2015), p. 57/58</span></span></span> -<span class="r-in"><span><span class="va">table_8</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">matrix</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">4</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fl">10</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nq"</span>, <span class="fl">2</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fl">10</span>, <span class="fl">10</span>, <span class="fl">10</span>, <span class="st">"nq"</span>, <span class="st">"nd"</span>, <span class="st">"nd"</span>,</span></span> -<span class="r-in"><span> <span class="st">"nq"</span>, <span class="fl">10</span>, <span class="st">"nq"</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">3</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="st">"nd"</span>, <span class="st">"nq"</span>, <span class="st">"nq"</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">3</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">6</span><span class="op">)</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">6</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> ncol <span class="op">=</span> <span class="fl">6</span>, byrow <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">table_8</span>, <span class="fl">0.5</span>, <span class="fl">1.5</span>, time_zero_presence <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [,1] [,2] [,3] [,4] [,5] [,6]</span> -<span class="r-out co"><span class="r-pr">#></span> [1,] 10.00 10.00 0.25 0.25 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [2,] 10.00 10.00 1.00 1.00 0.25 NA</span> -<span class="r-out co"><span class="r-pr">#></span> [3,] 10.00 10.00 10.00 1.00 0.25 NA</span> -<span class="r-out co"><span class="r-pr">#></span> [4,] 1.00 10.00 1.00 0.25 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [5,] 0.25 1.00 1.00 0.25 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [6,] NA 0.25 0.25 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [7,] NA NA NA NA NA NA</span> -<span class="r-in"><span><span class="va">table_10</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/matrix.html" class="external-link">matrix</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">10</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">4</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fl">10</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">4</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fl">10</span>, <span class="fl">10</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">3</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="st">"nd"</span>, <span class="fl">10</span>, <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">4</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="st">"nd"</span>, <span class="fl">18</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> ncol <span class="op">=</span> <span class="fl">6</span>, byrow <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">set_nd_nq</span><span class="op">(</span><span class="va">table_10</span>, <span class="fl">0.5</span>, time_zero_presence <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [,1] [,2] [,3] [,4] [,5] [,6]</span> -<span class="r-out co"><span class="r-pr">#></span> [1,] 10.00 10.00 0.25 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [2,] 10.00 10.00 0.25 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [3,] 10.00 10.00 10.00 0.25 NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [4,] 0.25 10.00 0.25 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [5,] NA 0.25 NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [6,] NA NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> [7,] NA NA NA NA NA NA</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/sigma_twocomp-1.png b/docs/dev/reference/sigma_twocomp-1.png Binary files differdeleted file mode 100644 index 3671c658..00000000 --- a/docs/dev/reference/sigma_twocomp-1.png +++ /dev/null diff --git a/docs/dev/reference/sigma_twocomp.html b/docs/dev/reference/sigma_twocomp.html deleted file mode 100644 index 0ead0184..00000000 --- a/docs/dev/reference/sigma_twocomp.html +++ /dev/null @@ -1,216 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, 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evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Two-component error model</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/sigma_twocomp.R" class="external-link"><code>R/sigma_twocomp.R</code></a></small> - <div class="hidden name"><code>sigma_twocomp.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Function describing the standard deviation of the measurement error in -dependence of the measured value \(y\):</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">sigma_twocomp</span><span class="op">(</span><span class="va">y</span>, <span class="va">sigma_low</span>, <span class="va">rsd_high</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>y</dt> -<dd><p>The magnitude of the observed value</p></dd> - - -<dt>sigma_low</dt> -<dd><p>The asymptotic minimum of the standard deviation for low -observed values</p></dd> - - -<dt>rsd_high</dt> -<dd><p>The coefficient describing the increase of the standard -deviation with the magnitude of the observed value</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The standard deviation of the response variable.</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>$$\sigma = \sqrt{ \sigma_{low}^2 + y^2 * {rsd}_{high}^2}$$ sigma = -sqrt(sigma_low^2 + y^2 * rsd_high^2)</p> -<p>This is the error model used for example by Werner et al. (1978). The model -proposed by Rocke and Lorenzato (1995) can be written in this form as well, -but assumes approximate lognormal distribution of errors for high values of -y.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>Werner, Mario, Brooks, Samuel H., and Knott, Lancaster B. (1978) -Additive, Multiplicative, and Mixed Analytical Errors. Clinical Chemistry -24(11), 1895-1898.</p> -<p>Rocke, David M. and Lorenzato, Stefan (1995) A two-component model for -measurement error in analytical chemistry. Technometrics 37(2), 176-184.</p> -<p>Ranke J and Meinecke S (2019) Error Models for the Kinetic Evaluation of Chemical -Degradation Data. <em>Environments</em> 6(12) 124 -<a href="https://doi.org/10.3390/environments6120124" class="external-link">doi:10.3390/environments6120124</a> -.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="va">times</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_pred</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>time <span class="op">=</span> <span class="va">times</span>, parent <span class="op">=</span> <span class="fl">100</span> <span class="op">*</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">exp</a></span><span class="op">(</span><span class="op">-</span> <span class="fl">0.03</span> <span class="op">*</span> <span class="va">times</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">123456</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">d_syn</span> <span class="op"><-</span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_pred</span>, <span class="kw">function</span><span class="op">(</span><span class="va">y</span><span class="op">)</span> <span class="fu">sigma_twocomp</span><span class="op">(</span><span class="va">y</span>, <span class="fl">1</span>, <span class="fl">0.07</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> reps <span class="op">=</span> <span class="fl">2</span>, n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span><span class="va">f_nls</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/nls.html" class="external-link">nls</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu"><a href="https://rdrr.io/r/stats/SSasymp.html" class="external-link">SSasymp</a></span><span class="op">(</span><span class="va">time</span>, <span class="fl">0</span>, <span class="va">parent_0</span>, <span class="va">lrc</span><span class="op">)</span>, data <span class="op">=</span> <span class="va">d_syn</span>,</span></span> -<span class="r-in"><span> start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>parent_0 <span class="op">=</span> <span class="fl">100</span>, lrc <span class="op">=</span> <span class="op">-</span><span class="fl">3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_gnls</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/gnls.html" class="external-link">gnls</a></span><span class="op">(</span><span class="va">value</span> <span class="op">~</span> <span class="fu"><a href="https://rdrr.io/r/stats/SSasymp.html" class="external-link">SSasymp</a></span><span class="op">(</span><span class="va">time</span>, <span class="fl">0</span>, <span class="va">parent_0</span>, <span class="va">lrc</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> data <span class="op">=</span> <span class="va">d_syn</span>, na.action <span class="op">=</span> <span class="va">na.omit</span>,</span></span> -<span class="r-in"><span> start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>parent_0 <span class="op">=</span> <span class="fl">100</span>, lrc <span class="op">=</span> <span class="op">-</span><span class="fl">3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/length.html" class="external-link">length</a></span><span class="op">(</span><span class="fu">findFunction</span><span class="op">(</span><span class="st">"varConstProp"</span><span class="op">)</span><span class="op">)</span> <span class="op">></span> <span class="fl">0</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">f_gnls_tc</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_gnls</span>, weights <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/varConstProp.html" class="external-link">varConstProp</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="va">f_gnls_tc_sf</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_gnls_tc</span>, control <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>sigma <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span><span class="va">f_mkin</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">d_syn</span>, error_model <span class="op">=</span> <span class="st">"const"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_mkin_tc</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">d_syn</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_res</a></span><span class="op">(</span><span class="va">f_mkin_tc</span>, standardized <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="sigma_twocomp-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nls</span>, <span class="va">f_gnls</span>, <span class="va">f_gnls_tc</span>, <span class="va">f_gnls_tc_sf</span>, <span class="va">f_mkin</span>, <span class="va">f_mkin_tc</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> f_nls 3 114.4817</span> -<span class="r-out co"><span class="r-pr">#></span> f_gnls 3 114.4817</span> -<span class="r-out co"><span class="r-pr">#></span> f_gnls_tc 5 103.6447</span> -<span class="r-out co"><span class="r-pr">#></span> f_gnls_tc_sf 4 101.6447</span> -<span class="r-out co"><span class="r-pr">#></span> f_mkin 3 114.4817</span> -<span class="r-out co"><span class="r-pr">#></span> f_mkin_tc 4 101.6446</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/status.html b/docs/dev/reference/status.html deleted file mode 100644 index df3e3a44..00000000 --- a/docs/dev/reference/status.html +++ /dev/null @@ -1,191 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Method to get status information for fit array objects — status • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link 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</button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Method to get status information for fit array objects</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/status.R" class="external-link"><code>R/status.R</code></a></small> - <div class="hidden name"><code>status.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Method to get status information for fit array objects</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">status</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu">status</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for status.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for mhmkin</span></span> -<span><span class="fu">status</span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for status.mhmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The object to investigate</p></dd> - - -<dt>...</dt> -<dd><p>For potential future extensions</p></dd> - - -<dt>x</dt> -<dd><p>The object to be printed</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>An object with the same dimensions as the fit array -suitable printing method.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span></span> -<span class="r-in"><span> <span class="st">"FOCUS B"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">status</span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model FOCUS A FOCUS B</span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary.mkinfit.html b/docs/dev/reference/summary.mkinfit.html deleted file mode 100644 index f627c2f6..00000000 --- a/docs/dev/reference/summary.mkinfit.html +++ /dev/null @@ -1,334 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "mkinfit" — summary.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" 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href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " mkinfit summary.mkinfit><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters with -some uncertainty statistics, the chi2 error levels calculated according to -FOCUS guidance (2006) as defined therein, formation fractions, DT50 values -and optionally the data, consisting of observed, predicted and residual -values."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script 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navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Summary method for class "mkinfit"</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.mkinfit.R" class="external-link"><code>R/summary.mkinfit.R</code></a></small> - <div class="hidden name"><code>summary.mkinfit.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Lists model equations, initial parameter values, optimised parameters with -some uncertainty statistics, the chi2 error levels calculated according to -FOCUS guidance (2006) as defined therein, formation fractions, DT50 values -and optionally the data, consisting of observed, predicted and residual -values.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, data <span class="op">=</span> <span class="cn">TRUE</span>, distimes <span class="op">=</span> <span class="cn">TRUE</span>, alpha <span class="op">=</span> <span class="fl">0.05</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for summary.mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>an object of class <a href="mkinfit.html">mkinfit</a>.</p></dd> - - -<dt>data</dt> -<dd><p>logical, indicating whether the data should be included in the -summary.</p></dd> - - -<dt>distimes</dt> -<dd><p>logical, indicating whether DT50 and DT90 values should be -included.</p></dd> - - -<dt>alpha</dt> -<dd><p>error level for confidence interval estimation from t -distribution</p></dd> - - -<dt>...</dt> -<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> - - -<dt>x</dt> -<dd><p>an object of class <code>summary.mkinfit</code>.</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The summary function returns a list with components, among others</p> -<dl><dt>version, Rversion</dt> -<dd><p>The mkin and R versions used</p></dd> - -<dt>date.fit, date.summary</dt> -<dd><p>The dates where the fit and the summary were -produced</p></dd> - -<dt>diffs</dt> -<dd><p>The differential equations used in the model</p></dd> - -<dt>use_of_ff</dt> -<dd><p>Was maximum or minimum use made of formation fractions</p></dd> - -<dt>bpar</dt> -<dd><p>Optimised and backtransformed -parameters</p></dd> - -<dt>data</dt> -<dd><p>The data (see Description above).</p></dd> - -<dt>start</dt> -<dd><p>The starting values and bounds, if applicable, for optimised -parameters.</p></dd> - -<dt>fixed</dt> -<dd><p>The values of fixed parameters.</p></dd> - -<dt>errmin </dt> -<dd><p>The chi2 error levels for -each observed variable.</p></dd> - -<dt>bparms.ode</dt> -<dd><p>All backtransformed ODE -parameters, for use as starting parameters for related models.</p></dd> - -<dt>errparms</dt> -<dd><p>Error model parameters.</p></dd> - -<dt>ff</dt> -<dd><p>The estimated formation fractions derived from the fitted -model.</p></dd> - -<dt>distimes</dt> -<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> - -<dt>SFORB</dt> -<dd><p>If applicable, eigenvalues and fractional eigenvector component -g of SFORB systems in the model.</p></dd> - -</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> - </div> - <div id="references"> - <h2>References</h2> - <p>FOCUS (2006) “Guidance Document on Estimating Persistence -and Degradation Kinetics from Environmental Fate Studies on Pesticides in -EU Registration” Report of the FOCUS Work Group on Degradation Kinetics, -EC Document Reference Sanco/10058/2005 version 2.0, 434 pp, -<a href="http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics" class="external-link">http://esdac.jrc.ec.europa.eu/projects/degradation-kinetics</a></p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">FOCUS_2006_A</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:34:39 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:34:39 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted using 131 model solutions performed in 0.009 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.24 state</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.10 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.240000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.302585 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 55.28197 55.5203 -24.64099</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 109.200 3.70400 99.630 118.700</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -3.291 0.09176 -3.527 -3.055</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.266 1.31600 1.882 8.649</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent sigma</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 5.428e-01 1.642e-07</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent 5.428e-01 1.000e+00 2.507e-07</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.642e-07 2.507e-07 1.000e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> -<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> -<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 109.20000 29.47 4.218e-07 99.6300 118.70000</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.03722 10.90 5.650e-05 0.0294 0.04712</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 5.26600 4.00 5.162e-03 1.8820 8.64900</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 8.385 2 6</span> -<span class="r-out co"><span class="r-pr">#></span> parent 8.385 2 6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 18.62 61.87</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> -<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.24 109.153 -7.9132</span> -<span class="r-out co"><span class="r-pr">#></span> 3 parent 99.27 97.622 1.6484</span> -<span class="r-out co"><span class="r-pr">#></span> 7 parent 90.11 84.119 5.9913</span> -<span class="r-out co"><span class="r-pr">#></span> 14 parent 72.19 64.826 7.3641</span> -<span class="r-out co"><span class="r-pr">#></span> 30 parent 29.71 35.738 -6.0283</span> -<span class="r-out co"><span class="r-pr">#></span> 62 parent 5.98 10.862 -4.8818</span> -<span class="r-out co"><span class="r-pr">#></span> 90 parent 1.54 3.831 -2.2911</span> -<span class="r-out co"><span class="r-pr">#></span> 118 parent 0.39 1.351 -0.9613</span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary.mmkin.html b/docs/dev/reference/summary.mmkin.html deleted file mode 100644 index c27f1634..00000000 --- a/docs/dev/reference/summary.mmkin.html +++ /dev/null @@ -1,196 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "mmkin" — summary.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " mmkin summary.mmkin><meta property="og:description" content="Shows status information on the mkinfit objects contained in the object -and gives an overview of ill-defined parameters calculated by illparms."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - 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Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Summary method for class "mmkin"</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.mmkin.R" class="external-link"><code>R/summary.mmkin.R</code></a></small> - <div class="hidden name"><code>summary.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Shows status information on the <a href="mkinfit.html">mkinfit</a> objects contained in the object -and gives an overview of ill-defined parameters calculated by <a href="illparms.html">illparms</a>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, conf.level <span class="op">=</span> <span class="fl">0.95</span>, <span class="va">...</span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for summary.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>an object of class <a href="mmkin.html">mmkin</a></p></dd> - - -<dt>conf.level</dt> -<dd><p>confidence level for testing parameters</p></dd> - - -<dt>...</dt> -<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> - - -<dt>x</dt> -<dd><p>an object of class <code>summary.mmkin</code>.</p></dd> - - -<dt>digits</dt> -<dd><p>number of digits to use for printing</p></dd> - -</dl></div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">fits</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"FOMC"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="st">"FOCUS A"</span> <span class="op">=</span> <span class="va">FOCUS_2006_A</span>,</span></span> -<span class="r-in"><span> <span class="st">"FOCUS C"</span> <span class="op">=</span> <span class="va">FOCUS_2006_C</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fits</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 0.509 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Status:</span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model FOCUS A FOCUS C</span> -<span class="r-out co"><span class="r-pr">#></span> SFO OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC OK OK </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> OK: No warnings</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Ill-defined parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> dataset</span> -<span class="r-out co"><span class="r-pr">#></span> model FOCUS A FOCUS C</span> -<span class="r-out co"><span class="r-pr">#></span> SFO </span> -<span class="r-out co"><span class="r-pr">#></span> FOMC parent_0, alpha, beta, sigma </span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary.nlme.mmkin.html b/docs/dev/reference/summary.nlme.mmkin.html deleted file mode 100644 index cb2c20bd..00000000 --- a/docs/dev/reference/summary.nlme.mmkin.html +++ /dev/null @@ -1,435 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "nlme.mmkin" — summary.nlme.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " nlme.mmkin summary.nlme.mmkin><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Summary method for class "nlme.mmkin"</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.nlme.mmkin.R" class="external-link"><code>R/summary.nlme.mmkin.R</code></a></small> - <div class="hidden name"><code>summary.nlme.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for nlme.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> data <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> distimes <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> alpha <span class="op">=</span> <span class="fl">0.05</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for summary.nlme.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>an object of class <a href="nlme.mmkin.html">nlme.mmkin</a></p></dd> - - -<dt>data</dt> -<dd><p>logical, indicating whether the full data should be included in -the summary.</p></dd> - - -<dt>verbose</dt> -<dd><p>Should the summary be verbose?</p></dd> - - -<dt>distimes</dt> -<dd><p>logical, indicating whether DT50 and DT90 values should be -included.</p></dd> - - -<dt>alpha</dt> -<dd><p>error level for confidence interval estimation from the t -distribution</p></dd> - - -<dt>...</dt> -<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> - - -<dt>x</dt> -<dd><p>an object of class summary.nlme.mmkin</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The summary function returns a list based on the <a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a> object -obtained in the fit, with at least the following additional components</p> -<dl><dt>nlmeversion, mkinversion, Rversion</dt> -<dd><p>The nlme, mkin and R versions used</p></dd> - -<dt>date.fit, date.summary</dt> -<dd><p>The dates where the fit and the summary were -produced</p></dd> - -<dt>diffs</dt> -<dd><p>The differential equations used in the degradation model</p></dd> - -<dt>use_of_ff</dt> -<dd><p>Was maximum or minimum use made of formation fractions</p></dd> - -<dt>data</dt> -<dd><p>The data</p></dd> - -<dt>confint_trans</dt> -<dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> - -<dt>confint_back</dt> -<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> - -<dt>ff</dt> -<dd><p>The estimated formation fractions derived from the fitted -model.</p></dd> - -<dt>distimes</dt> -<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> - -<dt>SFORB</dt> -<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> - -</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke for the mkin specific parts -José Pinheiro and Douglas Bates for the components inherited from nlme</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Generate five datasets following SFO kinetics</span></span></span> -<span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dt50_sfo_in_pop</span> <span class="op"><-</span> <span class="fl">50</span></span></span> -<span class="r-in"><span><span class="va">k_in_pop</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">2</span><span class="op">)</span> <span class="op">/</span> <span class="va">dt50_sfo_in_pop</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">k_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="va">k_in_pop</span><span class="op">)</span>, <span class="fl">0.5</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">pred_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">SFO</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="va">k</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">ds_sfo_mean</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">k_in</span>, <span class="va">pred_sfo</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_sfo_mean</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">12345</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">ds_sfo_syn</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_sfo_mean</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span></span> -<span class="r-in"><span> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># Evaluate using mmkin and nlme</span></span></span> -<span class="r-in"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://svn.r-project.org/R-packages/trunk/nlme/" class="external-link">nlme</a></span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_mmkin</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="va">ds_sfo_syn</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">1</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Optimisation did not converge:</span> -<span class="r-wrn co"><span class="r-pr">#></span> iteration limit reached without convergence (10)</span> -<span class="r-in"><span><span class="va">f_nlme</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlme</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> nlme version used for fitting: 3.1.162 </span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:34:41 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:34:41 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 90 observations of 1 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 0.194 s using 4 iterations</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Mean of starting values for individual parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent </span> -<span class="r-out co"><span class="r-pr">#></span> 101.569 -4.454 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 584.5 599.5 -286.2</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.371 101.592 103.814</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -4.973 -4.449 -3.926</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> parnt_0</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent 0.0507 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: list(parent_0 ~ 1, log_k_parent ~ 1)</span> -<span class="r-out co"><span class="r-pr">#></span> Level: ds</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Diagonal</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent Residual</span> -<span class="r-out co"><span class="r-pr">#></span> StdDev: 6.92e-05 0.5863 1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance function:</span> -<span class="r-out co"><span class="r-pr">#></span> Structure: Constant plus proportion of variance covariate</span> -<span class="r-out co"><span class="r-pr">#></span> Formula: ~fitted(.) </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter estimates:</span> -<span class="r-out co"><span class="r-pr">#></span> const prop </span> -<span class="r-out co"><span class="r-pr">#></span> 0.0001208154 0.0789968021 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters with asymmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.370882 101.59243 103.81398</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.006923 0.01168 0.01972</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 59.32 197.1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> ds name time observed predicted residual std standardized</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 104.1 101.592 2.50757 8.0255 0.312451</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 105.0 101.592 3.40757 8.0255 0.424594</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 98.5 100.796 -2.29571 7.9625 -0.288313</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 96.1 100.796 -4.69571 7.9625 -0.589725</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 101.9 99.221 2.67904 7.8381 0.341796</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 85.2 99.221 -14.02096 7.8381 -1.788812</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 99.1 96.145 2.95512 7.5951 0.389081</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 93.0 96.145 -3.14488 7.5951 -0.414065</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 88.1 90.989 -2.88944 7.1879 -0.401987</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 84.1 90.989 -6.88944 7.1879 -0.958480</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 80.2 81.493 -1.29305 6.4377 -0.200857</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 91.3 81.493 9.80695 6.4377 1.523364</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 65.1 63.344 1.75642 5.0039 0.351008</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 65.8 63.344 2.45642 5.0039 0.490898</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 47.8 50.018 -2.21764 3.9512 -0.561252</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 53.5 50.018 3.48236 3.9512 0.881335</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 37.6 39.495 -1.89515 3.1200 -0.607423</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 39.3 39.495 -0.19515 3.1200 -0.062549</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 107.9 101.592 6.30757 8.0255 0.785943</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 102.1 101.592 0.50757 8.0255 0.063245</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 103.8 100.058 3.74159 7.9043 0.473361</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 108.6 100.058 8.54159 7.9043 1.080626</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 91.0 97.060 -6.05952 7.6674 -0.790297</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 84.9 97.060 -12.15952 7.6674 -1.585874</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 79.3 91.329 -12.02867 7.2147 -1.667251</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 100.9 91.329 9.57133 7.2147 1.326647</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 77.3 82.102 -4.80185 6.4858 -0.740366</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 83.5 82.102 1.39815 6.4858 0.215571</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 66.8 66.351 0.44945 5.2415 0.085748</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 63.3 66.351 -3.05055 5.2415 -0.582002</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 40.8 40.775 0.02474 3.2211 0.007679</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 44.8 40.775 4.02474 3.2211 1.249485</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 27.8 25.832 1.96762 2.0407 0.964198</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 27.0 25.832 1.16762 2.0407 0.572171</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 15.2 16.366 -1.16561 1.2928 -0.901595</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 15.5 16.366 -0.86561 1.2928 -0.669547</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 97.7 101.592 -3.89243 8.0255 -0.485009</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 88.2 101.592 -13.39243 8.0255 -1.668739</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 109.9 99.218 10.68196 7.8379 1.362858</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 97.8 99.218 -1.41804 7.8379 -0.180921</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 100.5 94.634 5.86555 7.4758 0.784603</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 77.4 94.634 -17.23445 7.4758 -2.305360</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 78.3 86.093 -7.79273 6.8011 -1.145813</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 90.3 86.093 4.20727 6.8011 0.618620</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 76.0 72.958 3.04222 5.7634 0.527848</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 79.1 72.958 6.14222 5.7634 1.065722</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 46.0 52.394 -6.39404 4.1390 -1.544842</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 53.4 52.394 1.00596 4.1390 0.243046</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 25.1 24.582 0.51786 1.9419 0.266676</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 21.4 24.582 -3.18214 1.9419 -1.638664</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 11.0 12.092 -1.09202 0.9552 -1.143199</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 14.2 12.092 2.10798 0.9552 2.206776</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 5.8 5.948 -0.14810 0.4699 -0.315178</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 6.1 5.948 0.15190 0.4699 0.323282</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 95.3 101.592 -6.29243 8.0255 -0.784057</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 102.0 101.592 0.40757 8.0255 0.050784</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 104.4 101.125 3.27549 7.9885 0.410025</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 105.4 101.125 4.27549 7.9885 0.535205</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 113.7 100.195 13.50487 7.9151 1.706218</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 82.3 100.195 -17.89513 7.9151 -2.260886</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 98.1 98.362 -0.26190 7.7703 -0.033706</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 87.8 98.362 -10.56190 7.7703 -1.359270</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 97.9 95.234 2.66590 7.5232 0.354357</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 104.8 95.234 9.56590 7.5232 1.271521</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 85.0 89.274 -4.27372 7.0523 -0.606001</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 77.2 89.274 -12.07372 7.0523 -1.712017</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 82.2 77.013 5.18660 6.0838 0.852526</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 86.1 77.013 9.08660 6.0838 1.493571</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 70.5 67.053 3.44692 5.2970 0.650733</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 61.7 67.053 -5.35308 5.2970 -1.010591</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 60.0 58.381 1.61905 4.6119 0.351058</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 56.4 58.381 -1.98095 4.6119 -0.429530</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 92.6 101.592 -8.99243 8.0255 -1.120485</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 116.5 101.592 14.90757 8.0255 1.857531</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 108.0 99.914 8.08560 7.8929 1.024413</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 104.9 99.914 4.98560 7.8929 0.631655</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 100.5 96.641 3.85898 7.6343 0.505477</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 89.5 96.641 -7.14102 7.6343 -0.935383</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 91.7 90.412 1.28752 7.1423 0.180267</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 95.1 90.412 4.68752 7.1423 0.656304</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 82.2 80.463 1.73715 6.3563 0.273295</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 84.5 80.463 4.03715 6.3563 0.635141</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 60.5 63.728 -3.22788 5.0343 -0.641178</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 72.8 63.728 9.07212 5.0343 1.802062</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 38.3 37.399 0.90061 2.9544 0.304835</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 40.7 37.399 3.30061 2.9544 1.117174</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 22.5 22.692 -0.19165 1.7926 -0.106913</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 20.8 22.692 -1.89165 1.7926 -1.055273</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 13.4 13.768 -0.36790 1.0876 -0.338259</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 13.8 13.768 0.03210 1.0876 0.029517</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary.nlmixr.mmkin.html b/docs/dev/reference/summary.nlmixr.mmkin.html deleted file mode 100644 index 31f68f3f..00000000 --- a/docs/dev/reference/summary.nlmixr.mmkin.html +++ /dev/null @@ -1,2914 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Summary method for class "nlmixr.mmkin" — summary.nlmixr.mmkin • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script 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src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Summary method for class " nlmixr.mmkin summary.nlmixr.mmkin><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.1.0</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Functions and data</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Some benchmark timings</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Summary method for class "nlmixr.mmkin"</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.nlmixr.mmkin.R" class="external-link"><code>R/summary.nlmixr.mmkin.R</code></a></small> - <div class="hidden name"><code>summary.nlmixr.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="co"># S3 method for nlmixr.mmkin</span> -<span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">object</span>, data <span class="op">=</span> <span class="cn">FALSE</span>, verbose <span class="op">=</span> <span class="cn">FALSE</span>, distimes <span class="op">=</span> <span class="cn">TRUE</span>, <span class="va">...</span><span class="op">)</span> - -<span class="co"># S3 method for summary.nlmixr.mmkin</span> -<span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>an object of class <a href="nlmixr.mmkin.html">nlmixr.mmkin</a></p></dd> -<dt>data</dt> -<dd><p>logical, indicating whether the full data should be included in -the summary.</p></dd> -<dt>verbose</dt> -<dd><p>Should the summary be verbose?</p></dd> -<dt>distimes</dt> -<dd><p>logical, indicating whether DT50 and DT90 values should be -included.</p></dd> -<dt>...</dt> -<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> -<dt>x</dt> -<dd><p>an object of class summary.nlmixr.mmkin</p></dd> -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> -</dl></div> - <div id="value"> - <h2>Value</h2> - <p>The summary function returns a list obtained in the fit, with at -least the following additional components</p> -<dl><dt>nlmixrversion, mkinversion, Rversion</dt> -<dd><p>The nlmixr, mkin and R versions used</p></dd> -<dt>date.fit, date.summary</dt> -<dd><p>The dates where the fit and the summary were -produced</p></dd> -<dt>diffs</dt> -<dd><p>The differential equations used in the degradation model</p></dd> -<dt>use_of_ff</dt> -<dd><p>Was maximum or minimum use made of formation fractions</p></dd> -<dt>data</dt> -<dd><p>The data</p></dd> -<dt>confint_back</dt> -<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> -<dt>ff</dt> -<dd><p>The estimated formation fractions derived from the fitted -model.</p></dd> -<dt>distimes</dt> -<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> -<dt>SFORB</dt> -<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> -</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke for the mkin specific parts -nlmixr authors for the parts inherited from nlmixr.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="co"># Generate five datasets following DFOP-SFO kinetics</span></span> -<span class="r-in"><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span> -<span class="r-in"><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span> -<span class="r-in"> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span> -<span class="r-in"><span class="va">k1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.1</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> -<span class="r-in"><span class="va">k2_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> -<span class="r-in"><span class="va">g_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_parent_to_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span> -<span class="r-in"><span class="va">k_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">pred_dfop_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">f_parent_to_m1</span>, <span class="va">k_m1</span><span class="op">)</span> <span class="op">{</span></span> -<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> -<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1</span>, k2 <span class="op">=</span> <span class="va">k2</span>, g <span class="op">=</span> <span class="va">g</span>, f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1</span>, k_m1 <span class="op">=</span> <span class="va">k_m1</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> -<span class="r-in"><span class="op">}</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">ds_mean_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span> -<span class="r-in"> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span> -<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k2 <span class="op">=</span> <span class="va">k2_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, g <span class="op">=</span> <span class="va">g_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>,</span> -<span class="r-in"> f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k_m1 <span class="op">=</span> <span class="va">k_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span> -<span class="r-in"> <span class="va">sampling_times</span><span class="op">)</span></span> -<span class="r-in"><span class="op">}</span><span class="op">)</span></span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="va">ds_syn_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span> -<span class="r-in"> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span> -<span class="r-in"> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span> -<span class="r-in"> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span> -<span class="r-in"><span class="op">}</span><span class="op">)</span></span> -<span class="r-in"></span> -<span class="r-in"><span class="co"># \dontrun{</span></span> -<span class="r-in"><span class="co"># Evaluate using mmkin and nlmixr</span></span> -<span class="r-in"><span class="va">f_mmkin_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds_syn_dfop_sfo</span>,</span> -<span class="r-in"> quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_saemix_dfop_sfo</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_nlme_dfop_sfo</span> <span class="op"><-</span> <span class="fu">mkin</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/nlme.html" class="external-link">nlme</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_saem</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span>, est <span class="op">=</span> <span class="st">"saem"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> With est = 'saem', a different error model is required for each observed variableChanging the error model to 'obs_tc' (Two-component error for each observed variable)</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → generate SAEM model</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-out co"><span class="r-pr">#></span> 1: 99.5921 -3.9040 -2.1350 -3.7103 -2.0097 0.3217 6.6502 0.1520 0.5415 0.1995 0.3705 0.5588 7.9084 0.0824 7.5666 0.1777</span> -<span class="r-out co"><span class="r-pr">#></span> 2: 99.9835 -3.8650 -2.3586 -4.0306 -1.6536 0.0696 6.3177 0.1590 0.5144 0.1895 0.3520 0.5308 4.7746 0.0649 4.5667 0.0865</span> -<span class="r-out co"><span class="r-pr">#></span> 3: 1.0014e+02 -4.0173e+00 -2.3869e+00 -4.0840e+00 -1.2338e+00 3.4899e-02 6.0018e+00 1.5109e-01 4.8870e-01 1.8005e-01 3.3438e-01 5.0428e-01 2.8890e+00 7.0377e-02 2.9045e+00 9.5437e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 4: 1.0024e+02 -4.1414e+00 -2.4972e+00 -4.1082e+00 -1.0291e+00 -1.0684e-02 5.7017e+00 1.4354e-01 4.6427e-01 1.7105e-01 3.1766e-01 4.7907e-01 2.1715e+00 8.9921e-02 1.8765e+00 1.0403e-01</span> -<span class="r-out co"><span class="r-pr">#></span> 5: 1.0068e+02 -4.1132e+00 -2.4776e+00 -4.0576e+00 -1.0391e+00 -8.8738e-02 5.8192e+00 1.3636e-01 4.4106e-01 1.6249e-01 3.0177e-01 4.5512e-01 1.6349e+00 8.3197e-02 1.4947e+00 1.0221e-01</span> -<span class="r-out co"><span class="r-pr">#></span> 6: 1.0044e+02 -4.0883e+00 -2.3931e+00 -4.1068e+00 -9.5058e-01 -1.2696e-01 5.5283e+00 1.2954e-01 4.1900e-01 1.5437e-01 2.8669e-01 4.5581e-01 1.4126e+00 8.1219e-02 1.2286e+00 1.0043e-01</span> -<span class="r-out co"><span class="r-pr">#></span> 7: 1.0103e+02 -4.0833e+00 -2.4194e+00 -4.0894e+00 -9.8547e-01 5.2360e-03 9.8755e+00 1.2306e-01 3.9805e-01 1.4665e-01 2.7235e-01 5.3394e-01 1.3620e+00 7.9842e-02 1.0649e+00 1.0298e-01</span> -<span class="r-out co"><span class="r-pr">#></span> 8: 1.0106e+02 -4.0535e+00 -2.3489e+00 -4.0682e+00 -9.4455e-01 -9.4310e-02 9.3818e+00 1.1691e-01 3.7815e-01 1.3932e-01 2.5873e-01 5.0724e-01 1.2163e+00 7.0820e-02 1.0147e+00 9.2362e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 9: 1.0150e+02 -4.0498e+00 -2.4037e+00 -4.0719e+00 -9.3384e-01 -1.2384e-01 8.9127e+00 1.1107e-01 3.5924e-01 1.3235e-01 2.4580e-01 5.3463e-01 1.0849e+00 7.7513e-02 9.8295e-01 8.5927e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 10: 1.0089e+02 -4.0313e+00 -2.3670e+00 -4.0573e+00 -9.0269e-01 -1.6427e-01 8.4670e+00 1.0551e-01 3.4128e-01 1.2573e-01 2.3351e-01 5.4980e-01 1.1274e+00 7.6000e-02 9.8582e-01 8.9740e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 11: 1.0089e+02 -4.0664e+00 -2.3547e+00 -4.0554e+00 -9.3659e-01 -1.6900e-01 8.0437e+00 1.0024e-01 3.2422e-01 1.1945e-01 2.2183e-01 5.2231e-01 1.1513e+00 7.5801e-02 9.7638e-01 8.5324e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 12: 1.0067e+02 -4.0427e+00 -2.3729e+00 -4.0413e+00 -9.2169e-01 -2.0927e-01 8.6156e+00 9.5225e-02 3.0801e-01 1.1348e-01 2.1074e-01 6.0288e-01 1.1918e+00 7.4830e-02 9.1899e-01 8.7983e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 13: 1.0042e+02 -4.0387e+00 -2.3650e+00 -4.0623e+00 -9.3973e-01 -2.2277e-01 8.1848e+00 9.0463e-02 2.9260e-01 1.0780e-01 2.0020e-01 5.7274e-01 1.1022e+00 7.3652e-02 9.1657e-01 8.7973e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 14: 1.0020e+02 -4.0227e+00 -2.3586e+00 -4.0333e+00 -9.4451e-01 -1.8020e-01 7.7756e+00 8.5940e-02 2.7797e-01 1.0241e-01 1.9019e-01 5.4410e-01 1.0728e+00 8.0169e-02 7.8974e-01 9.0162e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 15: 1.0045e+02 -4.0209e+00 -2.3544e+00 -4.0187e+00 -8.9758e-01 -2.4348e-01 7.3868e+00 8.1643e-02 2.6408e-01 9.7291e-02 1.8068e-01 6.4534e-01 1.0287e+00 7.9387e-02 7.3357e-01 9.0858e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 16: 1.0061e+02 -4.0195e+00 -2.3678e+00 -4.0419e+00 -8.9130e-01 -2.4248e-01 7.0175e+00 7.7561e-02 2.5087e-01 9.2427e-02 1.7165e-01 6.7145e-01 1.0440e+00 7.9292e-02 8.4681e-01 8.5285e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 17: 1.0034e+02 -4.0298e+00 -2.3685e+00 -4.0637e+00 -8.9550e-01 -1.0712e-01 6.6666e+00 7.3683e-02 2.3833e-01 8.7805e-02 1.6307e-01 6.3788e-01 1.0827e+00 7.1441e-02 8.5278e-01 8.8090e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 18: 99.8774 -4.0600 -2.3805 -4.0726 -0.9545 -0.1196 6.3333 0.0700 0.2264 0.0834 0.1549 0.6060 1.0056 0.0751 0.8017 0.0877</span> -<span class="r-out co"><span class="r-pr">#></span> 19: 1.0055e+02 -4.0731e+00 -2.2711e+00 -4.0824e+00 -9.5827e-01 -5.9764e-02 6.0166e+00 6.6499e-02 2.1509e-01 7.9244e-02 1.4717e-01 5.7835e-01 9.3185e-01 7.9396e-02 8.2332e-01 9.1277e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 20: 1.0060e+02 -4.1023e+00 -2.2841e+00 -4.0757e+00 -9.7931e-01 -1.0440e-01 5.7158e+00 6.3174e-02 2.0434e-01 7.5282e-02 1.3981e-01 6.4675e-01 1.0006e+00 7.7840e-02 8.7958e-01 9.1512e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 21: 1.0095e+02 -4.0955e+00 -2.3274e+00 -4.1038e+00 -9.5611e-01 -5.2481e-02 5.8063e+00 6.0015e-02 1.9412e-01 7.1518e-02 1.3282e-01 6.4943e-01 1.0926e+00 7.2665e-02 9.0450e-01 8.6278e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 22: 1.0083e+02 -4.0789e+00 -2.3108e+00 -4.1074e+00 -9.6548e-01 -4.9665e-02 5.5160e+00 5.7014e-02 1.8441e-01 6.7942e-02 1.2618e-01 6.7304e-01 9.3297e-01 8.1042e-02 8.9206e-01 9.2336e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 23: 1.0114e+02 -4.0924e+00 -2.4027e+00 -4.0947e+00 -9.7291e-01 -5.0773e-02 5.2567e+00 5.4164e-02 1.7519e-01 6.5747e-02 1.1987e-01 7.3402e-01 9.7858e-01 8.2133e-02 8.4928e-01 8.8254e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 24: 1.0151e+02 -4.0787e+00 -2.3696e+00 -4.0712e+00 -9.5647e-01 -5.4136e-02 4.9938e+00 5.1456e-02 1.6643e-01 6.2460e-02 1.1388e-01 7.1847e-01 9.7548e-01 7.7691e-02 9.0418e-01 8.9115e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 25: 1.0158e+02 -4.0830e+00 -2.3384e+00 -4.0705e+00 -9.5727e-01 -8.4974e-02 4.7442e+00 4.8883e-02 1.5811e-01 5.9337e-02 1.0818e-01 6.8255e-01 1.0340e+00 7.4497e-02 9.0691e-01 9.0886e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 26: 1.0156e+02 -4.0784e+00 -2.3030e+00 -4.1027e+00 -9.5638e-01 -4.9456e-03 4.5069e+00 4.6439e-02 1.5021e-01 5.6370e-02 1.1189e-01 6.4842e-01 1.0537e+00 7.7612e-02 9.6725e-01 8.7824e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 27: 1.0198e+02 -4.0828e+00 -2.3006e+00 -4.0803e+00 -9.9402e-01 -8.3280e-02 4.2816e+00 4.4117e-02 1.4270e-01 5.3552e-02 1.3300e-01 6.1600e-01 9.1051e-01 7.7677e-02 9.5949e-01 8.6552e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 28: 1.0183e+02 -4.0871e+00 -2.2822e+00 -4.0596e+00 -9.9920e-01 -1.1469e-01 4.0675e+00 4.1911e-02 1.3556e-01 5.0874e-02 1.4021e-01 5.8520e-01 1.0294e+00 7.0917e-02 8.6440e-01 9.0301e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 29: 1.0171e+02 -4.0838e+00 -2.2606e+00 -4.0885e+00 -9.8937e-01 -6.6488e-02 4.3393e+00 3.9815e-02 1.2878e-01 4.8330e-02 1.3320e-01 5.5594e-01 1.0042e+00 8.1585e-02 8.5434e-01 8.6032e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 30: 1.0177e+02 -4.0861e+00 -2.2615e+00 -4.0670e+00 -9.9119e-01 -1.1322e-01 6.3058e+00 3.7825e-02 1.2942e-01 4.5914e-02 1.4223e-01 5.2814e-01 9.6301e-01 7.3336e-02 9.2366e-01 8.9276e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 31: 1.0160e+02 -4.0900e+00 -2.2455e+00 -4.0514e+00 -9.8754e-01 -2.2617e-01 5.9905e+00 3.5933e-02 1.2295e-01 4.3618e-02 1.3512e-01 5.2898e-01 1.0441e+00 7.6262e-02 1.0227e+00 8.3759e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 32: 1.0193e+02 -4.0967e+00 -2.2599e+00 -4.0295e+00 -9.8917e-01 -1.6626e-01 5.6910e+00 3.4137e-02 1.2620e-01 4.1437e-02 1.4303e-01 5.0253e-01 9.8083e-01 7.4136e-02 1.0031e+00 8.5124e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 33: 1.0215e+02 -4.0713e+00 -2.2563e+00 -4.0313e+00 -9.7361e-01 -1.8246e-01 5.4065e+00 3.2430e-02 1.1989e-01 3.9365e-02 1.5371e-01 4.7741e-01 9.6935e-01 8.0491e-02 9.7610e-01 8.0590e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 34: 1.0251e+02 -4.0707e+00 -2.2635e+00 -4.0387e+00 -9.2149e-01 -1.3452e-01 6.3940e+00 3.0808e-02 1.1389e-01 3.7397e-02 1.6720e-01 4.5354e-01 9.2449e-01 7.4355e-02 1.0505e+00 8.3049e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 35: 1.0278e+02 -4.0579e+00 -2.2877e+00 -4.0289e+00 -9.6632e-01 -1.2910e-01 6.0743e+00 2.9268e-02 1.0820e-01 3.5527e-02 1.7242e-01 4.3086e-01 1.0129e+00 7.3224e-02 1.0035e+00 7.9411e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 36: 1.0283e+02 -4.0771e+00 -2.2977e+00 -4.0108e+00 -9.5228e-01 -2.1781e-01 5.7706e+00 2.7805e-02 1.0279e-01 3.3751e-02 1.7034e-01 4.0932e-01 9.0249e-01 7.9917e-02 9.4562e-01 8.2391e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 37: 1.0228e+02 -4.0442e+00 -2.3061e+00 -4.0150e+00 -9.5376e-01 -1.4873e-01 5.4821e+00 2.6414e-02 9.7651e-02 3.2063e-02 1.7772e-01 3.8885e-01 9.0446e-01 8.1418e-02 9.7276e-01 8.3331e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 38: 1.0220e+02 -4.0454e+00 -2.3204e+00 -4.0207e+00 -9.3198e-01 -1.9324e-01 5.2080e+00 2.5094e-02 1.0946e-01 3.0460e-02 1.6883e-01 3.6941e-01 8.9159e-01 7.8645e-02 9.5848e-01 8.2734e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 39: 1.0193e+02 -4.0306e+00 -2.2926e+00 -4.0131e+00 -9.3448e-01 -2.1869e-01 6.7005e+00 2.3839e-02 1.0399e-01 2.8937e-02 1.6039e-01 3.5571e-01 9.0078e-01 7.8982e-02 9.3495e-01 8.3462e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 40: 1.0217e+02 -4.0463e+00 -2.2823e+00 -4.0209e+00 -9.2912e-01 -2.3580e-01 8.7857e+00 2.2647e-02 9.8789e-02 2.7490e-02 1.5418e-01 3.3792e-01 8.5126e-01 7.8849e-02 9.5510e-01 8.3011e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 41: 1.0210e+02 -4.0564e+00 -2.2213e+00 -4.0041e+00 -9.4137e-01 -2.4103e-01 9.2761e+00 2.1515e-02 9.5179e-02 2.6116e-02 1.4795e-01 3.9870e-01 9.8312e-01 7.1947e-02 1.0015e+00 8.1407e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 42: 1.0201e+02 -4.0204e+00 -2.2598e+00 -3.9984e+00 -9.4412e-01 -2.6838e-01 8.8123e+00 2.0439e-02 9.0420e-02 2.4810e-02 1.5013e-01 4.0334e-01 9.5583e-01 7.5617e-02 9.5131e-01 8.2343e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 43: 1.0244e+02 -4.0107e+00 -2.2178e+00 -3.9923e+00 -9.4481e-01 -3.1831e-01 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7.6769e-02 9.7255e-01 8.8653e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 89: 1.0031e+02 -4.0155e+00 -2.3418e+00 -4.0080e+00 -8.8958e-01 -1.4006e-01 3.3754e+00 7.4891e-03 2.4274e-01 1.2919e-02 1.3411e-01 2.3783e-01 8.9921e-01 8.3685e-02 9.2657e-01 8.1804e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 90: 1.0044e+02 -4.0279e+00 -2.3328e+00 -4.0081e+00 -9.1868e-01 -1.3077e-01 3.6776e+00 1.1221e-02 2.3380e-01 1.2419e-02 1.4247e-01 2.2594e-01 8.8620e-01 8.0520e-02 9.0269e-01 8.2413e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 91: 1.0007e+02 -4.0329e+00 -2.3865e+00 -4.0145e+00 -8.9566e-01 -1.2400e-01 3.7450e+00 1.0660e-02 2.2211e-01 1.3667e-02 1.3534e-01 2.1539e-01 9.5638e-01 8.0235e-02 9.4346e-01 8.5828e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 92: 1.0025e+02 -4.0506e+00 -2.3252e+00 -4.0445e+00 -9.2023e-01 -5.6654e-02 3.9282e+00 1.0127e-02 2.4912e-01 1.2984e-02 1.4349e-01 2.6955e-01 9.6021e-01 7.7975e-02 9.1878e-01 8.6695e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 93: 1.0091e+02 -4.0566e+00 -2.2760e+00 -4.0422e+00 -9.2960e-01 -5.8179e-02 3.7318e+00 9.6210e-03 2.6385e-01 1.3422e-02 1.5136e-01 2.5607e-01 9.7012e-01 7.7323e-02 1.0157e+00 8.6123e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 94: 1.0045e+02 -4.0682e+00 -2.3163e+00 -4.0391e+00 -9.3398e-01 -1.0367e-01 4.0009e+00 9.1399e-03 2.5066e-01 1.2751e-02 1.6029e-01 2.9867e-01 9.1442e-01 8.0048e-02 9.7607e-01 8.5436e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 95: 1.0029e+02 -4.0790e+00 -2.2791e+00 -4.0470e+00 -9.4031e-01 -7.2610e-02 3.8008e+00 8.6829e-03 2.3813e-01 1.2114e-02 1.5227e-01 2.8373e-01 8.9105e-01 8.2168e-02 9.5542e-01 8.5308e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 96: 1.0017e+02 -4.0818e+00 -2.3204e+00 -4.0507e+00 -9.2181e-01 -7.5195e-02 3.6108e+00 8.2488e-03 2.2622e-01 1.1508e-02 1.5273e-01 2.6955e-01 9.3179e-01 7.7026e-02 1.0092e+00 8.4966e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 97: 1.0007e+02 -4.0721e+00 -2.3606e+00 -4.0453e+00 -9.4375e-01 -7.2811e-02 3.4303e+00 1.0904e-02 2.1585e-01 1.2641e-02 1.8282e-01 2.5788e-01 9.3750e-01 8.0427e-02 9.3193e-01 8.3262e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 98: 1.0024e+02 -4.1025e+00 -2.3916e+00 -4.0401e+00 -9.6711e-01 -6.7764e-02 3.2587e+00 1.0359e-02 2.0506e-01 1.8712e-02 1.9260e-01 2.4499e-01 1.0086e+00 7.7282e-02 9.6010e-01 8.1760e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 99: 1.0024e+02 -4.0755e+00 -2.3237e+00 -4.0581e+00 -9.5543e-01 -8.1716e-02 3.0958e+00 9.8408e-03 1.9481e-01 1.7973e-02 1.8297e-01 2.5653e-01 8.6589e-01 7.7940e-02 9.2919e-01 8.4396e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 100: 1.0039e+02 -4.0828e+00 -2.2976e+00 -4.0616e+00 -9.8223e-01 -8.5593e-02 3.9873e+00 9.3488e-03 1.8507e-01 1.8837e-02 1.7382e-01 2.4370e-01 8.6471e-01 8.4021e-02 9.4587e-01 8.1697e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 101: 1.0089e+02 -4.0738e+00 -2.3406e+00 -4.0465e+00 -9.4824e-01 -4.4055e-02 5.2624e+00 8.8814e-03 1.8051e-01 1.7896e-02 1.6513e-01 2.3288e-01 8.4179e-01 8.2487e-02 8.8097e-01 8.1625e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 102: 1.0090e+02 -4.0777e+00 -2.3244e+00 -4.0500e+00 -9.4069e-01 -5.2554e-02 5.5339e+00 8.4373e-03 1.7148e-01 1.7001e-02 1.5688e-01 2.2124e-01 9.0419e-01 7.8446e-02 9.4721e-01 8.0896e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 103: 1.0067e+02 -4.0658e+00 -2.3188e+00 -4.0312e+00 -9.5981e-01 -7.3735e-02 7.0281e+00 8.0154e-03 1.6291e-01 1.6151e-02 1.7019e-01 2.1018e-01 9.3631e-01 8.1516e-02 9.8773e-01 8.0587e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 104: 1.0015e+02 -4.0729e+00 -2.3830e+00 -4.0458e+00 -9.4446e-01 -5.0075e-02 6.6767e+00 7.6147e-03 1.5476e-01 1.5343e-02 1.6822e-01 1.9967e-01 8.2373e-01 8.3029e-02 9.6909e-01 7.9505e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 105: 1.0022e+02 -4.0888e+00 -2.3301e+00 -4.0411e+00 -9.5279e-01 -1.1412e-01 6.3429e+00 7.2339e-03 1.4702e-01 1.4576e-02 1.8886e-01 2.2088e-01 9.2925e-01 7.3020e-02 1.0450e+00 8.6511e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 106: 1.0013e+02 -4.0846e+00 -2.3428e+00 -4.0530e+00 -9.1649e-01 -8.1899e-02 6.0257e+00 6.8722e-03 1.3967e-01 1.8939e-02 1.8350e-01 2.1970e-01 9.4571e-01 8.6259e-02 8.8509e-01 8.1023e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 107: 1.0026e+02 -4.0954e+00 -2.3362e+00 -4.0586e+00 -9.6302e-01 -8.0898e-03 5.7244e+00 6.5286e-03 1.3269e-01 2.2595e-02 2.0043e-01 2.4151e-01 8.8882e-01 8.8155e-02 8.2466e-01 8.5467e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 108: 1.0109e+02 -4.0796e+00 -2.3980e+00 -4.0841e+00 -9.5525e-01 2.0583e-02 5.4382e+00 6.2022e-03 1.2606e-01 3.4423e-02 2.2509e-01 2.3732e-01 9.0211e-01 8.1331e-02 9.2728e-01 8.4409e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 109: 1.0091e+02 -4.0872e+00 -2.3614e+00 -4.0620e+00 -9.5950e-01 -1.8283e-02 5.1663e+00 6.1750e-03 1.1975e-01 3.2702e-02 2.1384e-01 2.2546e-01 9.7296e-01 7.7298e-02 9.7366e-01 8.3784e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 110: 1.0137e+02 -4.0637e+00 -2.3734e+00 -4.0781e+00 -9.3874e-01 -6.0140e-03 4.9080e+00 6.5148e-03 1.1376e-01 3.1066e-02 2.0314e-01 2.3943e-01 9.2451e-01 8.4473e-02 9.7311e-01 8.4958e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 111: 1.0181e+02 -4.0588e+00 -2.3200e+00 -4.0792e+00 -9.9395e-01 -3.1776e-02 4.6626e+00 9.9112e-03 1.0808e-01 4.1755e-02 1.9299e-01 2.9896e-01 1.0697e+00 7.1561e-02 1.0062e+00 8.8034e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 112: 1.0222e+02 -4.0566e+00 -2.3525e+00 -4.0607e+00 -9.6055e-01 -6.3691e-02 4.4850e+00 9.4157e-03 1.0267e-01 4.0540e-02 1.8334e-01 3.5699e-01 1.0213e+00 7.5944e-02 1.0070e+00 8.3434e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 113: 1.0189e+02 -4.0478e+00 -2.3774e+00 -4.0434e+00 -9.6638e-01 -6.7729e-02 5.1753e+00 8.9449e-03 9.7539e-02 3.8513e-02 2.0339e-01 3.4044e-01 9.5484e-01 7.7854e-02 9.8545e-01 8.1852e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 114: 1.0225e+02 -4.0334e+00 -2.3728e+00 -4.0502e+00 -9.4795e-01 -7.3569e-02 4.9165e+00 8.8152e-03 9.2662e-02 3.7310e-02 2.0002e-01 3.2342e-01 9.3586e-01 8.1063e-02 9.5652e-01 8.3067e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 115: 1.0196e+02 -4.0302e+00 -2.3599e+00 -4.0812e+00 -9.6783e-01 7.1536e-03 4.8473e+00 9.4780e-03 1.0791e-01 3.7184e-02 1.9002e-01 3.0725e-01 9.1488e-01 7.6079e-02 1.0104e+00 8.7136e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 116: 1.0150e+02 -4.0420e+00 -2.3637e+00 -4.0535e+00 -9.4545e-01 -7.6387e-02 4.6049e+00 9.6408e-03 1.0251e-01 3.8115e-02 1.8052e-01 2.9189e-01 9.0583e-01 8.2597e-02 9.5680e-01 8.1246e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 117: 1.0161e+02 -4.0606e+00 -2.3853e+00 -4.0750e+00 -9.7273e-01 -2.7338e-03 4.3747e+00 9.1587e-03 9.7386e-02 3.7863e-02 1.8701e-01 2.7729e-01 8.4511e-01 8.4164e-02 9.4149e-01 8.0525e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 118: 1.0174e+02 -4.0727e+00 -2.3776e+00 -4.0850e+00 -9.6982e-01 -1.2188e-03 4.1560e+00 8.7008e-03 9.2516e-02 4.9300e-02 2.1364e-01 2.6343e-01 9.5447e-01 8.6627e-02 9.1835e-01 8.1284e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 119: 1.0141e+02 -4.0887e+00 -2.3138e+00 -4.0772e+00 -9.9409e-01 -5.0120e-02 3.9482e+00 8.2658e-03 8.7891e-02 4.6835e-02 2.5364e-01 2.5026e-01 9.4576e-01 8.4355e-02 9.5762e-01 8.5430e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 120: 1.0116e+02 -4.1014e+00 -2.3328e+00 -4.0418e+00 -9.7139e-01 -8.9664e-02 3.7508e+00 7.8525e-03 8.3496e-02 4.4493e-02 2.4096e-01 2.3774e-01 9.2816e-01 8.5558e-02 9.7817e-01 8.5169e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 121: 1.0099e+02 -4.0876e+00 -2.3277e+00 -4.0746e+00 -9.5453e-01 -2.6752e-02 3.5632e+00 7.4598e-03 7.9321e-02 4.2269e-02 2.2891e-01 2.2586e-01 8.9613e-01 8.0488e-02 9.7590e-01 8.4798e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 122: 1.0171e+02 -4.0620e+00 -2.3349e+00 -4.0659e+00 -9.4420e-01 -1.6907e-02 3.3851e+00 7.0869e-03 8.8424e-02 4.0155e-02 2.1747e-01 2.1456e-01 9.0159e-01 7.8017e-02 9.8579e-01 8.4585e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 123: 1.0191e+02 -4.0708e+00 -2.3487e+00 -4.0827e+00 -9.5025e-01 -5.7459e-03 3.2158e+00 6.7325e-03 1.0499e-01 3.8147e-02 2.0659e-01 2.0384e-01 9.6378e-01 7.4758e-02 9.6268e-01 8.4712e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 124: 1.0224e+02 -4.0798e+00 -2.2989e+00 -4.0724e+00 -9.8452e-01 -3.1802e-02 3.0550e+00 6.3959e-03 9.9739e-02 3.6240e-02 1.9626e-01 1.9364e-01 9.4424e-01 7.4219e-02 9.9842e-01 8.4793e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 125: 1.0242e+02 -4.0710e+00 -2.3242e+00 -4.0661e+00 -1.0094e+00 -2.9970e-02 2.9023e+00 6.0761e-03 9.4752e-02 3.6130e-02 1.8645e-01 1.8396e-01 9.2576e-01 8.0533e-02 9.9407e-01 8.1660e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 126: 1.0254e+02 -4.0685e+00 -2.3356e+00 -4.0599e+00 -1.0031e+00 4.0250e-03 2.7571e+00 5.7723e-03 1.0658e-01 3.4324e-02 1.7971e-01 1.7476e-01 9.4870e-01 7.4027e-02 9.2757e-01 8.3091e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 127: 1.0270e+02 -4.0492e+00 -2.3174e+00 -4.0476e+00 -9.9898e-01 -6.3197e-02 2.6193e+00 5.4837e-03 1.0746e-01 3.2607e-02 1.7072e-01 1.6603e-01 9.0721e-01 7.7941e-02 9.4624e-01 8.1077e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 128: 1.0284e+02 -4.0582e+00 -2.2991e+00 -4.0331e+00 -9.9114e-01 -5.6800e-02 2.4883e+00 5.2095e-03 1.2321e-01 3.1304e-02 1.6219e-01 1.5772e-01 8.7403e-01 8.4147e-02 8.9187e-01 8.5089e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 129: 1.0275e+02 -4.0773e+00 -2.2935e+00 -4.0389e+00 -9.9661e-01 -7.4747e-02 2.3639e+00 4.9922e-03 1.1705e-01 2.9738e-02 1.9667e-01 1.4984e-01 9.1481e-01 8.4947e-02 9.3224e-01 8.5270e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 130: 1.0222e+02 -4.0835e+00 -2.3177e+00 -4.0343e+00 -1.0044e+00 -7.6530e-02 2.2457e+00 4.7426e-03 1.1120e-01 3.1348e-02 2.0663e-01 1.4235e-01 1.0173e+00 7.4769e-02 9.9905e-01 8.6058e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 131: 1.0202e+02 -4.0767e+00 -2.2497e+00 -4.0270e+00 -1.0015e+00 -1.4868e-01 2.1334e+00 5.5790e-03 1.0564e-01 2.9781e-02 2.1254e-01 1.3523e-01 1.0223e+00 7.7587e-02 9.4151e-01 8.4206e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 132: 1.0191e+02 -4.0756e+00 -2.2363e+00 -4.0081e+00 -9.7264e-01 -2.0991e-01 2.0268e+00 5.3000e-03 1.0184e-01 2.8291e-02 2.0191e-01 1.7667e-01 9.2404e-01 7.9813e-02 9.2266e-01 8.6307e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 133: 1.0187e+02 -4.0743e+00 -2.1951e+00 -4.0196e+00 -9.7534e-01 -1.8742e-01 1.9254e+00 5.0350e-03 9.6744e-02 2.6877e-02 1.9181e-01 1.6784e-01 1.0007e+00 8.2043e-02 1.0028e+00 8.3921e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 134: 1.0182e+02 -4.0731e+00 -2.2321e+00 -4.0041e+00 -9.2800e-01 -1.4985e-01 1.8291e+00 4.7833e-03 9.1906e-02 2.7751e-02 1.8222e-01 1.6415e-01 9.7093e-01 7.5558e-02 9.8455e-01 8.4921e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 135: 1.0188e+02 -4.0724e+00 -2.2774e+00 -4.0213e+00 -9.3930e-01 -1.7385e-01 1.7377e+00 4.5441e-03 8.7311e-02 2.6363e-02 1.7311e-01 1.5594e-01 9.4053e-01 8.3922e-02 9.8689e-01 8.1203e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 136: 1.0202e+02 -4.0712e+00 -2.2711e+00 -4.0128e+00 -9.8747e-01 -1.3610e-01 1.6508e+00 4.3169e-03 1.0383e-01 2.5045e-02 1.8004e-01 1.4814e-01 9.6497e-01 8.1397e-02 1.0782e+00 8.2539e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 137: 1.0228e+02 -4.0676e+00 -2.2403e+00 -4.0069e+00 -9.7761e-01 -1.5314e-01 1.5683e+00 4.1011e-03 1.0931e-01 2.4722e-02 1.8328e-01 1.4074e-01 9.8300e-01 7.5906e-02 1.0221e+00 8.2306e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 138: 1.0229e+02 -4.0654e+00 -2.2510e+00 -3.9908e+00 -1.0400e+00 -1.4173e-01 1.4899e+00 4.2166e-03 1.3448e-01 2.3486e-02 1.8272e-01 1.3370e-01 1.0305e+00 8.0580e-02 1.0988e+00 8.3512e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 139: 1.0258e+02 -4.0599e+00 -2.2207e+00 -3.9622e+00 -1.0058e+00 -2.6676e-01 1.4154e+00 4.0057e-03 1.5190e-01 2.2312e-02 1.7359e-01 1.2702e-01 9.6425e-01 8.6887e-02 1.0373e+00 8.3853e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 140: 1.0224e+02 -4.0665e+00 -2.2479e+00 -4.0063e+00 -1.0054e+00 -1.6109e-01 1.3446e+00 3.8054e-03 1.4430e-01 2.4389e-02 1.6697e-01 1.2066e-01 9.9245e-01 8.3900e-02 1.1218e+00 8.2527e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 141: 1.0245e+02 -4.0843e+00 -2.2024e+00 -3.9657e+00 -1.0057e+00 -2.4900e-01 1.2774e+00 3.6152e-03 1.3709e-01 2.3170e-02 1.8559e-01 1.1463e-01 9.4091e-01 8.7616e-02 1.0760e+00 8.1871e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 142: 1.0253e+02 -4.0972e+00 -2.1943e+00 -3.9649e+00 -1.0160e+00 -2.9535e-01 1.2135e+00 3.4344e-03 1.6892e-01 2.2011e-02 1.7631e-01 1.0890e-01 9.2146e-01 9.0207e-02 1.0645e+00 8.5078e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 143: 1.0252e+02 -4.1005e+00 -2.1652e+00 -3.9687e+00 -1.0445e+00 -2.4274e-01 2.0559e+00 3.9136e-03 1.6047e-01 2.0911e-02 1.6750e-01 1.0345e-01 9.0785e-01 8.5522e-02 1.1734e+00 8.5544e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 144: 1.0257e+02 -4.1199e+00 -2.1994e+00 -3.9618e+00 -1.0480e+00 -2.0099e-01 1.9531e+00 4.2739e-03 1.5745e-01 1.9865e-02 1.6053e-01 9.8282e-02 9.3710e-01 8.5496e-02 1.0597e+00 8.4335e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 145: 1.0282e+02 -4.1356e+00 -2.1489e+00 -3.9708e+00 -1.0268e+00 -2.2250e-01 1.8554e+00 4.0602e-03 1.7177e-01 1.8872e-02 1.5251e-01 9.3368e-02 9.5312e-01 8.3609e-02 1.0695e+00 8.3492e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 146: 1.0282e+02 -4.1443e+00 -2.2103e+00 -3.9821e+00 -1.0080e+00 -2.2414e-01 1.7627e+00 4.0693e-03 1.6460e-01 1.7928e-02 1.5576e-01 8.8699e-02 9.8656e-01 8.4549e-02 1.0251e+00 7.9572e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 147: 1.0295e+02 -4.1363e+00 -2.1920e+00 -3.9828e+00 -1.0567e+00 -1.9047e-01 1.6745e+00 3.8659e-03 1.6104e-01 1.7032e-02 1.6551e-01 8.4264e-02 9.4144e-01 8.7085e-02 1.0623e+00 8.1949e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 148: 1.0299e+02 -4.1336e+00 -2.1967e+00 -3.9921e+00 -1.0425e+00 -1.7466e-01 1.7992e+00 3.6726e-03 1.5298e-01 1.9937e-02 1.9453e-01 8.0051e-02 9.9498e-01 8.3001e-02 1.0884e+00 8.1599e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 149: 1.0292e+02 -4.1282e+00 -2.2741e+00 -4.0028e+00 -1.0650e+00 -1.4879e-01 2.1425e+00 3.4890e-03 1.4534e-01 1.8941e-02 2.0240e-01 7.6049e-02 1.0080e+00 7.9550e-02 1.1679e+00 7.9115e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 150: 1.0302e+02 -4.1402e+00 -2.2769e+00 -4.0056e+00 -1.0488e+00 -1.2845e-01 2.7814e+00 3.3145e-03 1.3807e-01 2.0220e-02 1.9228e-01 7.2246e-02 9.9253e-01 8.0215e-02 1.0075e+00 8.2295e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 151: 1.0304e+02 -4.1281e+00 -2.2250e+00 -4.0169e+00 -1.0448e+00 -1.4468e-01 2.6423e+00 3.1488e-03 1.3117e-01 2.1298e-02 1.8267e-01 6.8634e-02 1.0207e+00 8.0317e-02 1.0813e+00 8.5492e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 152: 1.0321e+02 -4.1291e+00 -2.2281e+00 -4.0180e+00 -1.0232e+00 -1.4990e-01 1.6327e+00 2.8585e-03 1.0498e-01 1.8944e-02 1.6146e-01 5.0784e-02 9.5663e-01 7.9113e-02 1.1344e+00 8.2687e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 153: 1.0309e+02 -4.1280e+00 -2.2030e+00 -4.0149e+00 -1.0198e+00 -1.3442e-01 1.6757e+00 3.4142e-03 9.0693e-02 2.2471e-02 1.6167e-01 3.6279e-02 9.6659e-01 8.1655e-02 1.0345e+00 8.6113e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 154: 1.0298e+02 -4.1506e+00 -2.2176e+00 -3.9851e+00 -1.0417e+00 -1.6429e-01 1.9656e+00 3.3408e-03 9.5697e-02 2.1721e-02 1.6754e-01 2.9142e-02 1.0379e+00 7.9957e-02 1.0132e+00 8.5327e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 155: 1.0328e+02 -4.1204e+00 -2.2287e+00 -3.9772e+00 -1.0135e+00 -2.0459e-01 1.9195e+00 3.3987e-03 1.0293e-01 1.6897e-02 1.9470e-01 2.0826e-02 9.4310e-01 8.0528e-02 1.0639e+00 8.1926e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 156: 1.0338e+02 -4.1272e+00 -2.1962e+00 -3.9743e+00 -1.0491e+00 -1.8971e-01 1.7194e+00 3.2287e-03 7.8468e-02 1.8220e-02 1.8015e-01 2.0956e-02 9.2992e-01 8.6295e-02 9.5939e-01 8.1945e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 157: 1.0331e+02 -4.1188e+00 -2.1783e+00 -3.9779e+00 -1.0506e+00 -1.9810e-01 1.1127e+00 2.7176e-03 6.1234e-02 1.3748e-02 2.0147e-01 3.4800e-02 9.3006e-01 8.4794e-02 1.0579e+00 8.1604e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 158: 1.0326e+02 -4.1162e+00 -2.1734e+00 -3.9827e+00 -1.0632e+00 -2.0171e-01 1.3289e+00 2.7407e-03 7.1465e-02 1.2306e-02 2.1511e-01 3.4923e-02 8.9200e-01 8.4554e-02 1.1179e+00 8.2301e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 159: 1.0358e+02 -4.1075e+00 -2.2069e+00 -3.9725e+00 -1.0445e+00 -1.8044e-01 1.6656e+00 2.5282e-03 6.4340e-02 1.3587e-02 2.0355e-01 2.7629e-02 8.9557e-01 8.3727e-02 1.0560e+00 8.0934e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 160: 1.0364e+02 -4.1182e+00 -2.1514e+00 -3.9750e+00 -1.0378e+00 -2.2449e-01 1.8413e+00 3.5609e-03 7.2072e-02 1.5648e-02 2.0999e-01 3.1283e-02 9.1468e-01 8.2340e-02 1.0016e+00 8.0955e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 161: 1.0387e+02 -4.0964e+00 -2.1926e+00 -3.9808e+00 -1.0397e+00 -2.5178e-01 2.3706e+00 2.4158e-03 7.4658e-02 1.7789e-02 1.8587e-01 3.1647e-02 8.8257e-01 8.4503e-02 9.5909e-01 8.2216e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 162: 1.0399e+02 -4.0992e+00 -2.2056e+00 -3.9647e+00 -1.0388e+00 -2.4824e-01 1.9736e+00 2.2302e-03 1.0445e-01 1.9729e-02 1.9531e-01 2.9879e-02 8.3560e-01 8.6622e-02 9.5407e-01 7.9625e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 163: 1.0366e+02 -4.0956e+00 -2.1684e+00 -3.9612e+00 -1.0058e+00 -2.6882e-01 2.5872e+00 1.6246e-03 8.1892e-02 2.2777e-02 2.2429e-01 2.8371e-02 8.4799e-01 9.0947e-02 9.5842e-01 8.2649e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 164: 1.0325e+02 -4.0878e+00 -2.1946e+00 -3.9781e+00 -9.8890e-01 -2.6917e-01 2.0805e+00 1.3401e-03 8.2477e-02 2.6550e-02 1.8386e-01 2.4255e-02 8.5728e-01 8.9778e-02 9.1439e-01 7.9784e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 165: 1.0282e+02 -4.0801e+00 -2.1928e+00 -3.9664e+00 -9.9558e-01 -2.6059e-01 1.4087e+00 1.2155e-03 5.8081e-02 2.3833e-02 2.1871e-01 2.0911e-02 8.6998e-01 8.9895e-02 9.9363e-01 8.0284e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 166: 1.0285e+02 -4.0942e+00 -2.1855e+00 -3.9889e+00 -1.0234e+00 -2.4125e-01 8.5034e-01 6.8919e-04 6.5725e-02 2.3045e-02 2.1221e-01 2.6083e-02 8.7024e-01 9.4598e-02 9.5824e-01 8.3361e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 167: 1.0267e+02 -4.0904e+00 -2.2131e+00 -3.9917e+00 -9.9055e-01 -2.1449e-01 9.1382e-01 4.6145e-04 8.1337e-02 2.2154e-02 2.1431e-01 2.7524e-02 8.4730e-01 8.3563e-02 9.9458e-01 8.0138e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 168: 1.0249e+02 -4.0954e+00 -2.2174e+00 -3.9868e+00 -9.9799e-01 -1.8848e-01 6.5737e-01 4.2757e-04 6.9428e-02 2.8833e-02 2.0256e-01 4.1573e-02 9.8269e-01 7.6264e-02 1.0011e+00 8.1357e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 169: 1.0252e+02 -4.0995e+00 -2.2132e+00 -3.9792e+00 -9.8661e-01 -2.2724e-01 5.4553e-01 3.9691e-04 4.2460e-02 2.7545e-02 2.2594e-01 4.9079e-02 9.6027e-01 8.1006e-02 1.0261e+00 8.5194e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 170: 1.0246e+02 -4.1056e+00 -2.2389e+00 -3.9785e+00 -1.0354e+00 -2.4212e-01 4.5653e-01 2.8583e-04 2.8936e-02 2.5026e-02 1.8496e-01 4.3514e-02 9.2689e-01 9.6050e-02 9.9096e-01 8.3466e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 171: 1.0238e+02 -4.1027e+00 -2.2592e+00 -3.9859e+00 -1.0106e+00 -2.3962e-01 5.1080e-01 2.6715e-04 3.2138e-02 2.7859e-02 1.6505e-01 6.2560e-02 9.1886e-01 9.0993e-02 9.4634e-01 8.3542e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 172: 1.0242e+02 -4.0998e+00 -2.2415e+00 -3.9999e+00 -1.0234e+00 -2.2610e-01 5.1154e-01 1.8668e-04 2.2768e-02 2.9930e-02 2.0056e-01 7.5570e-02 9.4948e-01 8.4742e-02 9.1357e-01 8.3596e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 173: 1.0232e+02 -4.1005e+00 -2.2382e+00 -4.0022e+00 -1.0017e+00 -1.8406e-01 3.2169e-01 2.0484e-04 2.4102e-02 2.9249e-02 2.0445e-01 1.1517e-01 9.5169e-01 8.3951e-02 9.0402e-01 8.3130e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 174: 1.0233e+02 -4.0990e+00 -2.2337e+00 -3.9975e+00 -1.0298e+00 -1.8028e-01 4.2668e-01 2.1409e-04 2.4350e-02 2.4159e-02 2.0114e-01 1.4344e-01 9.3446e-01 8.6704e-02 9.6511e-01 8.3994e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 175: 1.0236e+02 -4.0991e+00 -2.2315e+00 -3.9883e+00 -1.0110e+00 -2.2190e-01 4.1564e-01 2.5844e-04 3.5664e-02 2.1844e-02 2.0315e-01 1.2876e-01 8.9006e-01 8.3016e-02 9.2369e-01 8.0410e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 176: 1.0222e+02 -4.0983e+00 -2.1991e+00 -3.9924e+00 -1.0148e+00 -2.3133e-01 1.7684e-01 2.5312e-04 5.3516e-02 2.2568e-02 2.0010e-01 1.0721e-01 8.9884e-01 7.6042e-02 1.0110e+00 7.9890e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 177: 1.0219e+02 -4.1022e+00 -2.2129e+00 -3.9804e+00 -1.0286e+00 -1.9916e-01 1.9962e-01 3.0338e-04 6.9476e-02 2.0133e-02 1.8707e-01 1.0631e-01 8.7419e-01 8.3199e-02 9.5450e-01 8.2626e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 178: 1.0225e+02 -4.1022e+00 -2.2135e+00 -4.0057e+00 -1.0264e+00 -2.2859e-01 2.1742e-01 2.9489e-04 5.1238e-02 2.2227e-02 1.7924e-01 1.4496e-01 8.5487e-01 8.3885e-02 9.7315e-01 8.1406e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 179: 1.0234e+02 -4.1015e+00 -2.2170e+00 -3.9999e+00 -1.0177e+00 -2.0895e-01 2.1196e-01 3.0802e-04 5.7417e-02 2.6776e-02 1.7214e-01 1.5197e-01 8.8641e-01 7.7789e-02 9.2725e-01 8.1277e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 180: 1.0243e+02 -4.1034e+00 -2.2337e+00 -4.0000e+00 -1.0018e+00 -2.3492e-01 2.0521e-01 3.1261e-04 6.0162e-02 2.7277e-02 1.7524e-01 1.6673e-01 8.8472e-01 7.8939e-02 9.1311e-01 8.3794e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 181: 1.0244e+02 -4.1031e+00 -2.2415e+00 -3.9951e+00 -9.9356e-01 -1.9938e-01 1.4850e-01 2.7894e-04 5.5244e-02 3.2404e-02 2.0701e-01 2.1022e-01 8.7495e-01 8.1883e-02 9.7574e-01 8.4575e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 182: 1.0245e+02 -4.1066e+00 -2.2849e+00 -4.0083e+00 -1.0260e+00 -1.9418e-01 1.0783e-01 1.7359e-04 2.9632e-02 3.2098e-02 2.0294e-01 1.7919e-01 9.0795e-01 9.1179e-02 9.8651e-01 8.3561e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 183: 1.0248e+02 -4.1066e+00 -2.2844e+00 -4.0201e+00 -1.0102e+00 -1.5510e-01 9.2727e-02 1.4337e-04 2.8436e-02 4.3941e-02 1.9683e-01 2.1943e-01 9.0334e-01 8.2113e-02 8.9037e-01 8.4506e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 184: 1.0239e+02 -4.1032e+00 -2.2726e+00 -4.0270e+00 -1.0162e+00 -1.4921e-01 9.0062e-02 1.0820e-04 3.5099e-02 4.7338e-02 1.8488e-01 2.2174e-01 9.1525e-01 7.9986e-02 8.6762e-01 8.4376e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 185: 1.0240e+02 -4.1028e+00 -2.3201e+00 -4.0248e+00 -9.8758e-01 -1.7235e-01 9.2455e-02 8.9653e-05 4.7097e-02 4.5964e-02 1.9093e-01 1.9093e-01 9.5192e-01 7.6980e-02 9.4058e-01 8.2740e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 186: 1.0250e+02 -4.1020e+00 -2.3095e+00 -4.0326e+00 -9.9767e-01 -1.2041e-01 1.0792e-01 7.3472e-05 3.6352e-02 4.6680e-02 1.7527e-01 1.7411e-01 9.6831e-01 8.3088e-02 9.7978e-01 8.1096e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 187: 1.0254e+02 -4.1022e+00 -2.3078e+00 -4.0329e+00 -1.0166e+00 -1.1644e-01 8.2987e-02 7.9222e-05 3.8388e-02 6.0452e-02 2.3498e-01 1.7389e-01 1.0450e+00 8.0354e-02 9.7366e-01 8.2504e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 188: 1.0253e+02 -4.1022e+00 -2.3172e+00 -4.0401e+00 -1.0276e+00 -8.2442e-02 8.3913e-02 7.1884e-05 4.3025e-02 4.8383e-02 1.9392e-01 1.6073e-01 9.7466e-01 7.5977e-02 9.0319e-01 8.4648e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 189: 1.0256e+02 -4.1013e+00 -2.3037e+00 -4.0402e+00 -1.0004e+00 -1.5946e-01 9.6273e-02 8.0773e-05 4.6130e-02 5.2356e-02 2.1044e-01 2.0403e-01 9.2931e-01 8.2686e-02 9.0103e-01 8.5442e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 190: 1.0245e+02 -4.1021e+00 -2.3143e+00 -4.0314e+00 -9.9314e-01 -8.5545e-02 8.0660e-02 7.3369e-05 4.1713e-02 4.4940e-02 1.7715e-01 1.6886e-01 9.7982e-01 8.1720e-02 8.9868e-01 8.4964e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 191: 1.0251e+02 -4.1021e+00 -2.2849e+00 -4.0229e+00 -1.0346e+00 -9.0261e-02 6.1956e-02 9.4824e-05 5.8037e-02 4.0685e-02 1.8455e-01 2.2838e-01 9.9679e-01 7.7457e-02 9.4591e-01 8.5446e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 192: 1.0249e+02 -4.1012e+00 -2.2915e+00 -4.0452e+00 -1.0323e+00 -1.1123e-01 5.1409e-02 1.1452e-04 7.2457e-02 3.6376e-02 1.6706e-01 2.1050e-01 8.7970e-01 8.6881e-02 9.2230e-01 8.6563e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 193: 1.0249e+02 -4.1011e+00 -2.3104e+00 -4.0569e+00 -1.0032e+00 -2.9383e-02 4.2462e-02 9.6872e-05 4.9405e-02 4.6840e-02 1.7348e-01 1.4473e-01 9.1758e-01 8.1380e-02 1.0057e+00 8.4481e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 194: 1.0250e+02 -4.1009e+00 -2.2960e+00 -4.0567e+00 -9.9145e-01 -1.0640e-01 2.6698e-02 5.3298e-05 4.3880e-02 5.1866e-02 2.0619e-01 1.4008e-01 9.8306e-01 8.0320e-02 9.8405e-01 8.0106e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 195: 1.0252e+02 -4.1001e+00 -2.2779e+00 -4.0677e+00 -9.9960e-01 -5.5605e-02 1.9114e-02 5.6472e-05 4.5810e-02 5.1552e-02 1.8363e-01 1.2037e-01 9.9334e-01 8.2093e-02 9.9128e-01 8.3930e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 196: 1.0251e+02 -4.0988e+00 -2.2515e+00 -4.0555e+00 -9.9701e-01 -1.0235e-01 1.3362e-02 3.2648e-05 4.0337e-02 4.4117e-02 1.9469e-01 1.2907e-01 9.1150e-01 8.5071e-02 9.7929e-01 8.2761e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 197: 1.0253e+02 -4.0985e+00 -2.2589e+00 -4.0427e+00 -1.0251e+00 -9.4695e-02 1.7104e-02 2.3125e-05 4.1773e-02 3.3831e-02 2.1013e-01 1.3727e-01 9.1462e-01 8.1836e-02 9.7695e-01 8.1326e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 198: 1.0253e+02 -4.0992e+00 -2.2745e+00 -4.0327e+00 -9.8743e-01 -1.4108e-01 9.3331e-03 2.3064e-05 3.7271e-02 2.7379e-02 2.1190e-01 9.3733e-02 9.0916e-01 8.4247e-02 9.8720e-01 7.7405e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 199: 1.0251e+02 -4.0981e+00 -2.2770e+00 -4.0275e+00 -1.0216e+00 -1.3364e-01 8.3776e-03 2.3195e-05 4.6827e-02 3.2861e-02 1.9817e-01 8.7748e-02 9.1184e-01 8.3773e-02 9.5209e-01 7.9056e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 200: 1.0252e+02 -4.0992e+00 -2.2757e+00 -4.0277e+00 -9.9266e-01 -8.4583e-02 6.8073e-03 2.9414e-05 5.3404e-02 2.5942e-02 1.9915e-01 7.4937e-02 8.7168e-01 8.5197e-02 9.3606e-01 8.0739e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 201: 1.0252e+02 -4.0989e+00 -2.2706e+00 -4.0333e+00 -9.8978e-01 -8.7996e-02 5.9272e-03 2.4268e-05 5.4295e-02 2.9276e-02 2.0543e-01 7.1533e-02 9.0557e-01 8.3204e-02 9.4913e-01 8.0398e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 202: 1.0251e+02 -4.0990e+00 -2.2661e+00 -4.0324e+00 -9.8785e-01 -9.8008e-02 5.7831e-03 2.1967e-05 5.7627e-02 3.0606e-02 2.1414e-01 6.9475e-02 9.2255e-01 8.2143e-02 9.5633e-01 8.1333e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 203: 1.0251e+02 -4.0992e+00 -2.2586e+00 -4.0297e+00 -9.9017e-01 -1.1012e-01 6.4046e-03 2.2234e-05 5.7955e-02 3.0102e-02 2.0473e-01 6.8225e-02 9.2900e-01 8.3228e-02 9.5862e-01 8.1460e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 204: 1.0251e+02 -4.0995e+00 -2.2570e+00 -4.0280e+00 -9.9135e-01 -1.0718e-01 6.5386e-03 2.2043e-05 5.6949e-02 2.9096e-02 2.0562e-01 6.8687e-02 9.3306e-01 8.2703e-02 9.6581e-01 8.1671e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 205: 1.0250e+02 -4.0997e+00 -2.2569e+00 -4.0256e+00 -9.9350e-01 -1.1491e-01 6.1521e-03 2.2570e-05 5.5450e-02 2.8152e-02 2.0423e-01 7.2820e-02 9.2469e-01 8.3272e-02 9.7372e-01 8.0814e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 206: 1.0250e+02 -4.0997e+00 -2.2567e+00 -4.0269e+00 -9.9869e-01 -1.1438e-01 5.9720e-03 2.3307e-05 5.5103e-02 2.8506e-02 2.0414e-01 7.8225e-02 9.2768e-01 8.3328e-02 9.8294e-01 8.0918e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 207: 1.0250e+02 -4.0998e+00 -2.2657e+00 -4.0311e+00 -1.0000e+00 -1.0595e-01 6.0030e-03 2.4031e-05 5.4378e-02 2.9468e-02 2.0222e-01 8.1455e-02 9.3397e-01 8.3285e-02 9.8989e-01 8.0967e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 208: 1.0250e+02 -4.0999e+00 -2.2759e+00 -4.0330e+00 -1.0001e+00 -9.6916e-02 5.9586e-03 2.3690e-05 5.3811e-02 2.9674e-02 1.9979e-01 8.1206e-02 9.3593e-01 8.4094e-02 9.8891e-01 8.1107e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 209: 1.0250e+02 -4.0998e+00 -2.2836e+00 -4.0344e+00 -1.0016e+00 -8.9119e-02 5.6137e-03 2.3512e-05 5.4159e-02 2.9780e-02 1.9778e-01 8.2635e-02 9.4080e-01 8.3757e-02 9.9062e-01 8.0979e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 210: 1.0251e+02 -4.0998e+00 -2.2898e+00 -4.0334e+00 -1.0017e+00 -8.3861e-02 5.2428e-03 2.3117e-05 5.4271e-02 2.9112e-02 1.9539e-01 8.3602e-02 9.4410e-01 8.4262e-02 9.8944e-01 8.1260e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 211: 1.0251e+02 -4.0998e+00 -2.2968e+00 -4.0329e+00 -9.9953e-01 -8.2036e-02 4.9312e-03 2.2863e-05 5.5392e-02 2.8432e-02 1.9466e-01 8.3724e-02 9.5395e-01 8.4317e-02 9.9876e-01 8.1402e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 212: 1.0251e+02 -4.0997e+00 -2.2982e+00 -4.0327e+00 -1.0018e+00 -8.2942e-02 4.6622e-03 2.3364e-05 5.5864e-02 2.7552e-02 1.9313e-01 8.3815e-02 9.5374e-01 8.4223e-02 1.0049e+00 8.1479e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 213: 1.0251e+02 -4.0995e+00 -2.2996e+00 -4.0322e+00 -1.0027e+00 -8.4931e-02 4.4988e-03 2.4085e-05 5.6000e-02 2.6729e-02 1.9184e-01 8.3522e-02 9.5091e-01 8.4321e-02 1.0026e+00 8.1310e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 214: 1.0251e+02 -4.0994e+00 -2.2997e+00 -4.0326e+00 -1.0033e+00 -8.7810e-02 4.3582e-03 2.5253e-05 5.6470e-02 2.6179e-02 1.9110e-01 8.5338e-02 9.5311e-01 8.4118e-02 1.0062e+00 8.1320e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 215: 1.0251e+02 -4.0993e+00 -2.3013e+00 -4.0331e+00 -1.0042e+00 -8.5053e-02 4.3765e-03 2.6370e-05 5.6978e-02 2.5984e-02 1.8960e-01 8.6633e-02 9.5505e-01 8.3787e-02 1.0092e+00 8.1298e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 216: 1.0251e+02 -4.0993e+00 -2.3032e+00 -4.0320e+00 -1.0033e+00 -8.5521e-02 4.4127e-03 2.7607e-05 5.7092e-02 2.5514e-02 1.8916e-01 8.8986e-02 9.5571e-01 8.3655e-02 1.0106e+00 8.1177e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 217: 1.0251e+02 -4.0993e+00 -2.3050e+00 -4.0309e+00 -1.0039e+00 -8.5267e-02 4.4663e-03 2.8101e-05 5.7536e-02 2.5186e-02 1.8803e-01 9.0776e-02 9.5624e-01 8.3792e-02 1.0100e+00 8.1214e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 218: 1.0251e+02 -4.0993e+00 -2.3068e+00 -4.0309e+00 -1.0052e+00 -8.3353e-02 4.4833e-03 2.7541e-05 5.7391e-02 2.4589e-02 1.8691e-01 9.4302e-02 9.5168e-01 8.4114e-02 1.0124e+00 8.1211e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 219: 1.0251e+02 -4.0993e+00 -2.3077e+00 -4.0316e+00 -1.0049e+00 -8.0885e-02 4.4529e-03 2.6825e-05 5.7273e-02 2.3909e-02 1.8700e-01 9.6040e-02 9.4675e-01 8.4115e-02 1.0115e+00 8.1075e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 220: 1.0251e+02 -4.0993e+00 -2.3095e+00 -4.0327e+00 -1.0051e+00 -7.6386e-02 4.5217e-03 2.6724e-05 5.7342e-02 2.3648e-02 1.8752e-01 9.7466e-02 9.4316e-01 8.4134e-02 1.0099e+00 8.1206e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 221: 1.0251e+02 -4.0993e+00 -2.3120e+00 -4.0339e+00 -1.0050e+00 -7.3314e-02 4.5361e-03 2.6133e-05 5.7387e-02 2.3612e-02 1.8744e-01 9.9108e-02 9.4164e-01 8.4073e-02 1.0096e+00 8.1143e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 222: 1.0251e+02 -4.0993e+00 -2.3136e+00 -4.0355e+00 -1.0049e+00 -6.8041e-02 4.5806e-03 2.5728e-05 5.7827e-02 2.3466e-02 1.8681e-01 9.9150e-02 9.4237e-01 8.3991e-02 1.0116e+00 8.1192e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 223: 1.0251e+02 -4.0993e+00 -2.3144e+00 -4.0364e+00 -1.0047e+00 -6.6770e-02 4.5349e-03 2.5412e-05 5.8823e-02 2.3232e-02 1.8728e-01 9.9882e-02 9.4051e-01 8.3808e-02 1.0097e+00 8.1028e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 224: 1.0251e+02 -4.0992e+00 -2.3155e+00 -4.0373e+00 -1.0040e+00 -6.4487e-02 4.4985e-03 2.5094e-05 6.0294e-02 2.3022e-02 1.8652e-01 1.0114e-01 9.3800e-01 8.3696e-02 1.0099e+00 8.0990e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 225: 1.0251e+02 -4.0992e+00 -2.3167e+00 -4.0384e+00 -1.0041e+00 -6.2966e-02 4.4783e-03 2.4741e-05 6.0569e-02 2.2900e-02 1.8622e-01 1.0072e-01 9.3574e-01 8.3833e-02 1.0075e+00 8.0893e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 226: 1.0251e+02 -4.0993e+00 -2.3173e+00 -4.0395e+00 -1.0036e+00 -6.0541e-02 4.4466e-03 2.4601e-05 6.0661e-02 2.2897e-02 1.8544e-01 1.0160e-01 9.3842e-01 8.3565e-02 1.0064e+00 8.1006e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 227: 1.0251e+02 -4.0993e+00 -2.3183e+00 -4.0403e+00 -1.0028e+00 -5.9061e-02 4.4290e-03 2.4610e-05 6.1093e-02 2.2836e-02 1.8582e-01 1.0184e-01 9.3983e-01 8.3421e-02 1.0066e+00 8.1225e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 228: 1.0251e+02 -4.0993e+00 -2.3190e+00 -4.0405e+00 -1.0027e+00 -5.8994e-02 4.4377e-03 2.4228e-05 6.0957e-02 2.2540e-02 1.8424e-01 1.0104e-01 9.4056e-01 8.3559e-02 1.0085e+00 8.1266e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 229: 1.0251e+02 -4.0993e+00 -2.3206e+00 -4.0398e+00 -1.0026e+00 -5.9258e-02 4.5021e-03 2.3801e-05 6.0331e-02 2.2380e-02 1.8409e-01 9.9681e-02 9.4320e-01 8.3678e-02 1.0111e+00 8.1236e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 230: 1.0251e+02 -4.0994e+00 -2.3217e+00 -4.0401e+00 -1.0028e+00 -5.7766e-02 4.5320e-03 2.3519e-05 5.9913e-02 2.2317e-02 1.8484e-01 9.9325e-02 9.4418e-01 8.3884e-02 1.0144e+00 8.1294e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 231: 1.0251e+02 -4.0994e+00 -2.3223e+00 -4.0400e+00 -1.0036e+00 -5.7213e-02 4.6519e-03 2.3658e-05 5.9386e-02 2.2185e-02 1.8526e-01 9.8374e-02 9.4356e-01 8.4167e-02 1.0171e+00 8.1315e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 232: 1.0251e+02 -4.0994e+00 -2.3231e+00 -4.0400e+00 -1.0045e+00 -5.5248e-02 4.7067e-03 2.3117e-05 5.9583e-02 2.2248e-02 1.8574e-01 9.7396e-02 9.4340e-01 8.4212e-02 1.0179e+00 8.1401e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 233: 1.0251e+02 -4.0994e+00 -2.3237e+00 -4.0401e+00 -1.0046e+00 -5.4085e-02 4.7534e-03 2.2858e-05 5.8985e-02 2.2248e-02 1.8649e-01 9.7364e-02 9.4271e-01 8.4248e-02 1.0189e+00 8.1456e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 234: 1.0251e+02 -4.0995e+00 -2.3238e+00 -4.0400e+00 -1.0042e+00 -5.2957e-02 4.8433e-03 2.2715e-05 5.8868e-02 2.2174e-02 1.8630e-01 9.7975e-02 9.4382e-01 8.4160e-02 1.0210e+00 8.1665e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 235: 1.0251e+02 -4.0995e+00 -2.3248e+00 -4.0396e+00 -1.0044e+00 -5.3132e-02 4.8769e-03 2.2540e-05 5.9052e-02 2.2120e-02 1.8627e-01 9.8772e-02 9.4330e-01 8.4170e-02 1.0196e+00 8.1627e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 236: 1.0251e+02 -4.0995e+00 -2.3244e+00 -4.0392e+00 -1.0052e+00 -5.3786e-02 4.8860e-03 2.2664e-05 5.8981e-02 2.2095e-02 1.8771e-01 9.8852e-02 9.4172e-01 8.4214e-02 1.0191e+00 8.1698e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 237: 1.0251e+02 -4.0996e+00 -2.3231e+00 -4.0386e+00 -1.0056e+00 -5.5158e-02 4.8731e-03 2.2576e-05 5.8788e-02 2.2037e-02 1.8860e-01 9.9599e-02 9.4242e-01 8.4097e-02 1.0198e+00 8.1684e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 238: 1.0251e+02 -4.0996e+00 -2.3222e+00 -4.0384e+00 -1.0054e+00 -5.6412e-02 4.8673e-03 2.2575e-05 5.8733e-02 2.1962e-02 1.8874e-01 9.9196e-02 9.4097e-01 8.4103e-02 1.0208e+00 8.1649e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 239: 1.0251e+02 -4.0996e+00 -2.3212e+00 -4.0382e+00 -1.0068e+00 -5.7131e-02 4.8223e-03 2.2398e-05 5.8674e-02 2.1817e-02 1.8926e-01 9.9323e-02 9.4261e-01 8.4059e-02 1.0229e+00 8.1670e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 240: 1.0251e+02 -4.0996e+00 -2.3216e+00 -4.0376e+00 -1.0073e+00 -5.6962e-02 4.7984e-03 2.2260e-05 5.8558e-02 2.1632e-02 1.8892e-01 9.9232e-02 9.4434e-01 8.4130e-02 1.0237e+00 8.1679e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 241: 1.0251e+02 -4.0996e+00 -2.3216e+00 -4.0371e+00 -1.0078e+00 -5.6984e-02 4.7767e-03 2.2074e-05 5.9552e-02 2.1436e-02 1.8860e-01 9.9285e-02 9.4491e-01 8.4026e-02 1.0247e+00 8.1680e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 242: 1.0251e+02 -4.0996e+00 -2.3222e+00 -4.0372e+00 -1.0079e+00 -5.6422e-02 4.7880e-03 2.2014e-05 6.0033e-02 2.1277e-02 1.8860e-01 9.8674e-02 9.4359e-01 8.3991e-02 1.0255e+00 8.1634e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 243: 1.0251e+02 -4.0995e+00 -2.3227e+00 -4.0376e+00 -1.0079e+00 -5.4330e-02 4.7944e-03 2.1687e-05 6.0189e-02 2.1088e-02 1.8830e-01 9.7952e-02 9.4207e-01 8.4036e-02 1.0257e+00 8.1666e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 244: 1.0251e+02 -4.0995e+00 -2.3237e+00 -4.0385e+00 -1.0076e+00 -5.2834e-02 4.7916e-03 2.1467e-05 6.0432e-02 2.1062e-02 1.8810e-01 9.7065e-02 9.4039e-01 8.4075e-02 1.0248e+00 8.1599e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 245: 1.0251e+02 -4.0995e+00 -2.3249e+00 -4.0390e+00 -1.0073e+00 -5.0542e-02 4.7926e-03 2.1549e-05 6.1095e-02 2.0981e-02 1.8814e-01 9.6715e-02 9.3900e-01 8.4049e-02 1.0226e+00 8.1505e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 246: 1.0251e+02 -4.0995e+00 -2.3261e+00 -4.0398e+00 -1.0066e+00 -4.7686e-02 4.8114e-03 2.1557e-05 6.1692e-02 2.0969e-02 1.8783e-01 9.6477e-02 9.3880e-01 8.4024e-02 1.0211e+00 8.1456e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 247: 1.0251e+02 -4.0996e+00 -2.3270e+00 -4.0406e+00 -1.0063e+00 -4.5794e-02 4.7864e-03 2.1709e-05 6.1819e-02 2.0928e-02 1.8765e-01 9.5549e-02 9.3939e-01 8.4076e-02 1.0201e+00 8.1427e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 248: 1.0251e+02 -4.0995e+00 -2.3282e+00 -4.0412e+00 -1.0064e+00 -4.3009e-02 4.7307e-03 2.1707e-05 6.2309e-02 2.0970e-02 1.8795e-01 9.5221e-02 9.3898e-01 8.4080e-02 1.0197e+00 8.1501e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 249: 1.0251e+02 -4.0996e+00 -2.3298e+00 -4.0417e+00 -1.0070e+00 -4.1062e-02 4.7070e-03 2.1737e-05 6.2607e-02 2.1094e-02 1.8796e-01 9.5103e-02 9.3917e-01 8.4069e-02 1.0194e+00 8.1525e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 250: 1.0251e+02 -4.0996e+00 -2.3313e+00 -4.0420e+00 -1.0073e+00 -3.9250e-02 4.7191e-03 2.1947e-05 6.2963e-02 2.1053e-02 1.8834e-01 9.4954e-02 9.3851e-01 8.4115e-02 1.0190e+00 8.1496e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 251: 1.0251e+02 -4.0997e+00 -2.3317e+00 -4.0424e+00 -1.0078e+00 -3.7549e-02 4.7501e-03 2.2063e-05 6.3160e-02 2.0958e-02 1.8840e-01 9.4783e-02 9.3749e-01 8.4137e-02 1.0185e+00 8.1476e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 252: 1.0251e+02 -4.0997e+00 -2.3319e+00 -4.0424e+00 -1.0083e+00 -3.6657e-02 4.7441e-03 2.2081e-05 6.3250e-02 2.0891e-02 1.8911e-01 9.4954e-02 9.3708e-01 8.4108e-02 1.0180e+00 8.1479e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 253: 1.0251e+02 -4.0997e+00 -2.3323e+00 -4.0425e+00 -1.0085e+00 -3.5826e-02 4.7409e-03 2.2021e-05 6.3513e-02 2.0810e-02 1.8920e-01 9.5196e-02 9.3509e-01 8.4179e-02 1.0184e+00 8.1440e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 254: 1.0251e+02 -4.0997e+00 -2.3324e+00 -4.0426e+00 -1.0086e+00 -3.6456e-02 4.7046e-03 2.1929e-05 6.3535e-02 2.0859e-02 1.9010e-01 9.5077e-02 9.3362e-01 8.4279e-02 1.0185e+00 8.1371e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 255: 1.0251e+02 -4.0997e+00 -2.3313e+00 -4.0424e+00 -1.0088e+00 -3.7358e-02 4.6636e-03 2.1827e-05 6.3864e-02 2.0820e-02 1.9126e-01 9.4979e-02 9.3183e-01 8.4380e-02 1.0185e+00 8.1434e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 256: 1.0251e+02 -4.0997e+00 -2.3306e+00 -4.0423e+00 -1.0086e+00 -3.8558e-02 4.6418e-03 2.1776e-05 6.4176e-02 2.0845e-02 1.9175e-01 9.4890e-02 9.3144e-01 8.4436e-02 1.0188e+00 8.1420e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 257: 1.0251e+02 -4.0997e+00 -2.3297e+00 -4.0419e+00 -1.0092e+00 -3.9580e-02 4.6134e-03 2.1742e-05 6.4408e-02 2.0751e-02 1.9188e-01 9.4692e-02 9.3113e-01 8.4507e-02 1.0187e+00 8.1412e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 258: 1.0251e+02 -4.0997e+00 -2.3287e+00 -4.0415e+00 -1.0090e+00 -4.0619e-02 4.5918e-03 2.1710e-05 6.4634e-02 2.0663e-02 1.9172e-01 9.4422e-02 9.3104e-01 8.4479e-02 1.0189e+00 8.1395e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 259: 1.0251e+02 -4.0997e+00 -2.3284e+00 -4.0412e+00 -1.0086e+00 -4.1245e-02 4.5889e-03 2.1741e-05 6.5035e-02 2.0678e-02 1.9132e-01 9.3998e-02 9.2986e-01 8.4448e-02 1.0177e+00 8.1368e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 260: 1.0251e+02 -4.0997e+00 -2.3283e+00 -4.0410e+00 -1.0084e+00 -4.1907e-02 4.5818e-03 2.1877e-05 6.5755e-02 2.0691e-02 1.9113e-01 9.3631e-02 9.2955e-01 8.4378e-02 1.0172e+00 8.1346e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 261: 1.0251e+02 -4.0998e+00 -2.3282e+00 -4.0409e+00 -1.0087e+00 -4.2022e-02 4.5724e-03 2.1946e-05 6.6396e-02 2.0714e-02 1.9084e-01 9.3140e-02 9.2882e-01 8.4426e-02 1.0166e+00 8.1329e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 262: 1.0251e+02 -4.0997e+00 -2.3275e+00 -4.0408e+00 -1.0092e+00 -4.2439e-02 4.5357e-03 2.1842e-05 6.6895e-02 2.0692e-02 1.9082e-01 9.2527e-02 9.2811e-01 8.4447e-02 1.0168e+00 8.1339e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 263: 1.0251e+02 -4.0998e+00 -2.3269e+00 -4.0407e+00 -1.0097e+00 -4.2867e-02 4.5244e-03 2.1830e-05 6.7068e-02 2.0721e-02 1.9077e-01 9.2003e-02 9.2800e-01 8.4366e-02 1.0171e+00 8.1343e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 264: 1.0251e+02 -4.0998e+00 -2.3262e+00 -4.0403e+00 -1.0102e+00 -4.3066e-02 4.4987e-03 2.1812e-05 6.7458e-02 2.0718e-02 1.9065e-01 9.1528e-02 9.2710e-01 8.4389e-02 1.0163e+00 8.1355e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 265: 1.0251e+02 -4.0998e+00 -2.3264e+00 -4.0401e+00 -1.0105e+00 -4.3042e-02 4.4865e-03 2.1721e-05 6.7680e-02 2.0722e-02 1.9057e-01 9.1243e-02 9.2631e-01 8.4430e-02 1.0154e+00 8.1321e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 266: 1.0251e+02 -4.0998e+00 -2.3264e+00 -4.0397e+00 -1.0107e+00 -4.3247e-02 4.4552e-03 2.1609e-05 6.8246e-02 2.0757e-02 1.9054e-01 9.1222e-02 9.2659e-01 8.4381e-02 1.0154e+00 8.1290e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 267: 1.0251e+02 -4.0999e+00 -2.3261e+00 -4.0396e+00 -1.0107e+00 -4.4145e-02 4.4367e-03 2.1505e-05 6.8834e-02 2.0735e-02 1.9038e-01 9.1594e-02 9.2661e-01 8.4338e-02 1.0153e+00 8.1308e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 268: 1.0251e+02 -4.0999e+00 -2.3249e+00 -4.0395e+00 -1.0112e+00 -4.5394e-02 4.4239e-03 2.1411e-05 6.9776e-02 2.0749e-02 1.9017e-01 9.1916e-02 9.2711e-01 8.4286e-02 1.0158e+00 8.1400e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 269: 1.0251e+02 -4.0999e+00 -2.3236e+00 -4.0391e+00 -1.0112e+00 -4.6744e-02 4.4119e-03 2.1310e-05 7.0528e-02 2.0709e-02 1.9026e-01 9.2008e-02 9.2638e-01 8.4248e-02 1.0160e+00 8.1389e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 270: 1.0251e+02 -4.0999e+00 -2.3231e+00 -4.0388e+00 -1.0116e+00 -4.7514e-02 4.3782e-03 2.1160e-05 7.1513e-02 2.0724e-02 1.9006e-01 9.1551e-02 9.2668e-01 8.4246e-02 1.0149e+00 8.1419e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 271: 1.0251e+02 -4.0999e+00 -2.3228e+00 -4.0387e+00 -1.0117e+00 -4.7755e-02 4.3389e-03 2.1121e-05 7.1868e-02 2.0670e-02 1.8969e-01 9.1369e-02 9.2678e-01 8.4228e-02 1.0145e+00 8.1437e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 272: 1.0251e+02 -4.0999e+00 -2.3222e+00 -4.0387e+00 -1.0121e+00 -4.8163e-02 4.3080e-03 2.1146e-05 7.2226e-02 2.0710e-02 1.8983e-01 9.0962e-02 9.2639e-01 8.4261e-02 1.0132e+00 8.1523e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 273: 1.0251e+02 -4.0999e+00 -2.3216e+00 -4.0389e+00 -1.0122e+00 -4.8336e-02 4.2916e-03 2.1202e-05 7.2734e-02 2.0689e-02 1.8982e-01 9.0422e-02 9.2618e-01 8.4177e-02 1.0134e+00 8.1561e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 274: 1.0251e+02 -4.0999e+00 -2.3211e+00 -4.0388e+00 -1.0124e+00 -4.8286e-02 4.2592e-03 2.1201e-05 7.3324e-02 2.0658e-02 1.9015e-01 8.9938e-02 9.2530e-01 8.4133e-02 1.0133e+00 8.1562e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 275: 1.0251e+02 -4.0999e+00 -2.3211e+00 -4.0387e+00 -1.0128e+00 -4.8312e-02 4.2368e-03 2.1092e-05 7.3673e-02 2.0639e-02 1.9018e-01 8.9708e-02 9.2404e-01 8.4155e-02 1.0130e+00 8.1535e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 276: 1.0251e+02 -4.0999e+00 -2.3212e+00 -4.0386e+00 -1.0126e+00 -4.8249e-02 4.2070e-03 2.0985e-05 7.4089e-02 2.0674e-02 1.8992e-01 8.9341e-02 9.2339e-01 8.4163e-02 1.0121e+00 8.1515e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 277: 1.0251e+02 -4.0999e+00 -2.3212e+00 -4.0387e+00 -1.0123e+00 -4.8743e-02 4.1781e-03 2.0914e-05 7.4488e-02 2.0779e-02 1.8959e-01 8.9106e-02 9.2352e-01 8.4100e-02 1.0112e+00 8.1477e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 278: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0385e+00 -1.0118e+00 -4.9468e-02 4.1782e-03 2.0802e-05 7.4843e-02 2.0859e-02 1.8970e-01 8.8995e-02 9.2374e-01 8.4037e-02 1.0103e+00 8.1458e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 279: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0384e+00 -1.0115e+00 -4.9612e-02 4.1736e-03 2.0737e-05 7.5385e-02 2.0899e-02 1.8969e-01 8.8806e-02 9.2347e-01 8.3989e-02 1.0095e+00 8.1440e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 280: 1.0251e+02 -4.0999e+00 -2.3213e+00 -4.0382e+00 -1.0114e+00 -5.0460e-02 4.1900e-03 2.0708e-05 7.6051e-02 2.0933e-02 1.8968e-01 8.9243e-02 9.2293e-01 8.3972e-02 1.0085e+00 8.1467e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 281: 1.0251e+02 -4.0999e+00 -2.3215e+00 -4.0378e+00 -1.0113e+00 -5.0583e-02 4.2096e-03 2.0638e-05 7.6759e-02 2.1003e-02 1.8941e-01 8.9450e-02 9.2294e-01 8.4027e-02 1.0080e+00 8.1467e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 282: 1.0251e+02 -4.0999e+00 -2.3218e+00 -4.0380e+00 -1.0114e+00 -5.0276e-02 4.2061e-03 2.0669e-05 7.7323e-02 2.1016e-02 1.8946e-01 8.9456e-02 9.2386e-01 8.3996e-02 1.0095e+00 8.1446e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 283: 1.0251e+02 -4.0999e+00 -2.3224e+00 -4.0383e+00 -1.0115e+00 -4.9357e-02 4.2005e-03 2.0601e-05 7.7856e-02 2.1072e-02 1.8968e-01 8.9327e-02 9.2480e-01 8.3964e-02 1.0101e+00 8.1418e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 284: 1.0251e+02 -4.0999e+00 -2.3226e+00 -4.0386e+00 -1.0110e+00 -4.8703e-02 4.1977e-03 2.0549e-05 7.8183e-02 2.1122e-02 1.8956e-01 8.9430e-02 9.2470e-01 8.3898e-02 1.0098e+00 8.1428e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 285: 1.0251e+02 -4.0999e+00 -2.3232e+00 -4.0389e+00 -1.0110e+00 -4.7526e-02 4.2063e-03 2.0546e-05 7.8449e-02 2.1151e-02 1.8967e-01 8.9133e-02 9.2438e-01 8.3889e-02 1.0089e+00 8.1428e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 286: 1.0251e+02 -4.0999e+00 -2.3242e+00 -4.0389e+00 -1.0103e+00 -4.6191e-02 4.2076e-03 2.0486e-05 7.8629e-02 2.1133e-02 1.8970e-01 8.8773e-02 9.2471e-01 8.3861e-02 1.0087e+00 8.1427e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 287: 1.0251e+02 -4.0999e+00 -2.3243e+00 -4.0391e+00 -1.0105e+00 -4.5159e-02 4.1980e-03 2.0488e-05 7.8916e-02 2.1071e-02 1.8955e-01 8.8297e-02 9.2415e-01 8.3957e-02 1.0084e+00 8.1464e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 288: 1.0251e+02 -4.0999e+00 -2.3237e+00 -4.0392e+00 -1.0109e+00 -4.4970e-02 4.1921e-03 2.0495e-05 7.8764e-02 2.0953e-02 1.8988e-01 8.8160e-02 9.2539e-01 8.3963e-02 1.0103e+00 8.1466e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 289: 1.0251e+02 -4.0999e+00 -2.3232e+00 -4.0392e+00 -1.0114e+00 -4.4592e-02 4.1763e-03 2.0584e-05 7.8632e-02 2.0841e-02 1.8982e-01 8.8037e-02 9.2559e-01 8.4031e-02 1.0111e+00 8.1469e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 290: 1.0251e+02 -4.0999e+00 -2.3228e+00 -4.0393e+00 -1.0118e+00 -4.4506e-02 4.1574e-03 2.0479e-05 7.8482e-02 2.0726e-02 1.8968e-01 8.7644e-02 9.2519e-01 8.4079e-02 1.0117e+00 8.1474e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 291: 1.0251e+02 -4.0999e+00 -2.3223e+00 -4.0392e+00 -1.0120e+00 -4.4578e-02 4.1365e-03 2.0488e-05 7.8220e-02 2.0662e-02 1.8952e-01 8.7558e-02 9.2534e-01 8.4128e-02 1.0119e+00 8.1459e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 292: 1.0251e+02 -4.0999e+00 -2.3219e+00 -4.0392e+00 -1.0120e+00 -4.4486e-02 4.1205e-03 2.0514e-05 7.8288e-02 2.0601e-02 1.8947e-01 8.7669e-02 9.2591e-01 8.4106e-02 1.0124e+00 8.1443e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 293: 1.0251e+02 -4.0999e+00 -2.3217e+00 -4.0395e+00 -1.0120e+00 -4.3914e-02 4.1076e-03 2.0606e-05 7.8474e-02 2.0557e-02 1.8960e-01 8.7970e-02 9.2580e-01 8.4052e-02 1.0124e+00 8.1443e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 294: 1.0251e+02 -4.0998e+00 -2.3218e+00 -4.0399e+00 -1.0123e+00 -4.3173e-02 4.1124e-03 2.0598e-05 7.8561e-02 2.0485e-02 1.8979e-01 8.7954e-02 9.2624e-01 8.4027e-02 1.0132e+00 8.1419e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 295: 1.0251e+02 -4.0998e+00 -2.3220e+00 -4.0399e+00 -1.0123e+00 -4.2805e-02 4.1150e-03 2.0599e-05 7.8804e-02 2.0397e-02 1.8985e-01 8.8079e-02 9.2637e-01 8.3980e-02 1.0139e+00 8.1382e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 296: 1.0251e+02 -4.0998e+00 -2.3224e+00 -4.0401e+00 -1.0121e+00 -4.2813e-02 4.1342e-03 2.0618e-05 7.9093e-02 2.0359e-02 1.8980e-01 8.8328e-02 9.2555e-01 8.3955e-02 1.0137e+00 8.1344e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 297: 1.0251e+02 -4.0998e+00 -2.3225e+00 -4.0403e+00 -1.0118e+00 -4.2861e-02 4.1653e-03 2.0599e-05 7.9236e-02 2.0318e-02 1.8969e-01 8.8659e-02 9.2477e-01 8.3916e-02 1.0135e+00 8.1323e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 298: 1.0251e+02 -4.0997e+00 -2.3228e+00 -4.0404e+00 -1.0116e+00 -4.2874e-02 4.2066e-03 2.0567e-05 7.9391e-02 2.0249e-02 1.8973e-01 8.8706e-02 9.2359e-01 8.3939e-02 1.0134e+00 8.1277e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 299: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0404e+00 -1.0113e+00 -4.3190e-02 4.2168e-03 2.0532e-05 7.9379e-02 2.0187e-02 1.8973e-01 8.8757e-02 9.2294e-01 8.3916e-02 1.0137e+00 8.1243e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 300: 1.0251e+02 -4.0997e+00 -2.3221e+00 -4.0405e+00 -1.0111e+00 -4.3480e-02 4.2289e-03 2.0490e-05 7.9314e-02 2.0140e-02 1.8983e-01 8.8620e-02 9.2242e-01 8.3900e-02 1.0137e+00 8.1210e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 301: 1.0251e+02 -4.0997e+00 -2.3213e+00 -4.0404e+00 -1.0109e+00 -4.4169e-02 4.2524e-03 2.0546e-05 7.9499e-02 2.0117e-02 1.8991e-01 8.8503e-02 9.2226e-01 8.3843e-02 1.0136e+00 8.1235e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 302: 1.0251e+02 -4.0997e+00 -2.3205e+00 -4.0403e+00 -1.0108e+00 -4.5199e-02 4.2709e-03 2.0511e-05 7.9674e-02 2.0085e-02 1.8969e-01 8.8687e-02 9.2207e-01 8.3852e-02 1.0134e+00 8.1262e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 303: 1.0251e+02 -4.0997e+00 -2.3199e+00 -4.0401e+00 -1.0106e+00 -4.6193e-02 4.2807e-03 2.0440e-05 7.9845e-02 2.0104e-02 1.8985e-01 8.8661e-02 9.2135e-01 8.3843e-02 1.0128e+00 8.1274e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 304: 1.0251e+02 -4.0997e+00 -2.3189e+00 -4.0398e+00 -1.0105e+00 -4.7180e-02 4.3058e-03 2.0450e-05 7.9808e-02 2.0159e-02 1.8987e-01 8.8660e-02 9.2076e-01 8.3856e-02 1.0120e+00 8.1277e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 305: 1.0251e+02 -4.0997e+00 -2.3180e+00 -4.0396e+00 -1.0102e+00 -4.8474e-02 4.3050e-03 2.0527e-05 7.9932e-02 2.0184e-02 1.8970e-01 8.8567e-02 9.1986e-01 8.3867e-02 1.0111e+00 8.1290e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 306: 1.0251e+02 -4.0997e+00 -2.3175e+00 -4.0393e+00 -1.0101e+00 -4.9308e-02 4.3055e-03 2.0586e-05 8.0113e-02 2.0178e-02 1.8971e-01 8.8307e-02 9.1930e-01 8.3865e-02 1.0112e+00 8.1290e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 307: 1.0251e+02 -4.0997e+00 -2.3175e+00 -4.0393e+00 -1.0103e+00 -4.9278e-02 4.3027e-03 2.0441e-05 8.0168e-02 2.0211e-02 1.8973e-01 8.7993e-02 9.1919e-01 8.3837e-02 1.0109e+00 8.1287e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 308: 1.0251e+02 -4.0998e+00 -2.3175e+00 -4.0394e+00 -1.0103e+00 -4.9430e-02 4.2899e-03 2.0384e-05 8.0417e-02 2.0187e-02 1.8983e-01 8.7757e-02 9.1937e-01 8.3778e-02 1.0106e+00 8.1289e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 309: 1.0251e+02 -4.0998e+00 -2.3175e+00 -4.0393e+00 -1.0103e+00 -4.9319e-02 4.2773e-03 2.0349e-05 8.0807e-02 2.0161e-02 1.8959e-01 8.7493e-02 9.1950e-01 8.3734e-02 1.0108e+00 8.1279e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 310: 1.0251e+02 -4.0998e+00 -2.3174e+00 -4.0393e+00 -1.0101e+00 -4.8880e-02 4.2710e-03 2.0327e-05 8.1202e-02 2.0116e-02 1.8983e-01 8.7251e-02 9.1864e-01 8.3730e-02 1.0108e+00 8.1294e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 311: 1.0251e+02 -4.0998e+00 -2.3174e+00 -4.0394e+00 -1.0100e+00 -4.8080e-02 4.2611e-03 2.0272e-05 8.1332e-02 2.0078e-02 1.9003e-01 8.6995e-02 9.1844e-01 8.3699e-02 1.0105e+00 8.1319e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 312: 1.0251e+02 -4.0998e+00 -2.3173e+00 -4.0394e+00 -1.0100e+00 -4.7724e-02 4.2663e-03 2.0239e-05 8.1553e-02 2.0021e-02 1.8982e-01 8.6721e-02 9.1838e-01 8.3721e-02 1.0100e+00 8.1312e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 313: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0395e+00 -1.0100e+00 -4.7216e-02 4.2775e-03 2.0213e-05 8.2001e-02 1.9971e-02 1.8980e-01 8.6651e-02 9.1837e-01 8.3697e-02 1.0100e+00 8.1318e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 314: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0398e+00 -1.0100e+00 -4.6902e-02 4.2949e-03 2.0265e-05 8.2392e-02 1.9922e-02 1.8988e-01 8.6426e-02 9.1845e-01 8.3722e-02 1.0103e+00 8.1309e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 315: 1.0251e+02 -4.0998e+00 -2.3168e+00 -4.0399e+00 -1.0102e+00 -4.6480e-02 4.3206e-03 2.0314e-05 8.2534e-02 1.9912e-02 1.8972e-01 8.6211e-02 9.1792e-01 8.3758e-02 1.0103e+00 8.1337e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 316: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0400e+00 -1.0100e+00 -4.6238e-02 4.3456e-03 2.0323e-05 8.2729e-02 1.9936e-02 1.8975e-01 8.5856e-02 9.1759e-01 8.3814e-02 1.0095e+00 8.1353e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 317: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0402e+00 -1.0103e+00 -4.5470e-02 4.3521e-03 2.0275e-05 8.2864e-02 1.9965e-02 1.8980e-01 8.5438e-02 9.1755e-01 8.3894e-02 1.0088e+00 8.1373e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 318: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0402e+00 -1.0106e+00 -4.5001e-02 4.3661e-03 2.0191e-05 8.2949e-02 1.9983e-02 1.9001e-01 8.5203e-02 9.1746e-01 8.3944e-02 1.0078e+00 8.1401e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 319: 1.0251e+02 -4.0998e+00 -2.3169e+00 -4.0403e+00 -1.0108e+00 -4.4545e-02 4.3665e-03 2.0114e-05 8.2694e-02 2.0003e-02 1.9041e-01 8.4997e-02 9.1774e-01 8.3940e-02 1.0073e+00 8.1417e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 320: 1.0251e+02 -4.0998e+00 -2.3171e+00 -4.0402e+00 -1.0109e+00 -4.4419e-02 4.3600e-03 2.0043e-05 8.2516e-02 1.9999e-02 1.9044e-01 8.4873e-02 9.1798e-01 8.3932e-02 1.0070e+00 8.1420e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 321: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0401e+00 -1.0107e+00 -4.4267e-02 4.3539e-03 1.9995e-05 8.2307e-02 1.9967e-02 1.9050e-01 8.4982e-02 9.1814e-01 8.3919e-02 1.0067e+00 8.1429e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 322: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0400e+00 -1.0106e+00 -4.4240e-02 4.3331e-03 1.9984e-05 8.2305e-02 1.9961e-02 1.9054e-01 8.5443e-02 9.1821e-01 8.3910e-02 1.0065e+00 8.1424e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 323: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0397e+00 -1.0105e+00 -4.4793e-02 4.3199e-03 1.9921e-05 8.2300e-02 1.9935e-02 1.9078e-01 8.6081e-02 9.1836e-01 8.3854e-02 1.0062e+00 8.1448e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 324: 1.0251e+02 -4.0998e+00 -2.3167e+00 -4.0395e+00 -1.0104e+00 -4.4862e-02 4.3167e-03 1.9926e-05 8.2063e-02 1.9919e-02 1.9086e-01 8.6736e-02 9.1865e-01 8.3834e-02 1.0060e+00 8.1439e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 325: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0394e+00 -1.0103e+00 -4.5123e-02 4.3012e-03 1.9902e-05 8.1871e-02 1.9888e-02 1.9103e-01 8.7030e-02 9.1829e-01 8.3865e-02 1.0059e+00 8.1436e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 326: 1.0251e+02 -4.0998e+00 -2.3166e+00 -4.0393e+00 -1.0100e+00 -4.5111e-02 4.2839e-03 1.9869e-05 8.2016e-02 1.9843e-02 1.9083e-01 8.7106e-02 9.1802e-01 8.3847e-02 1.0058e+00 8.1427e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 327: 1.0251e+02 -4.0998e+00 -2.3165e+00 -4.0393e+00 -1.0101e+00 -4.5297e-02 4.2847e-03 1.9858e-05 8.2297e-02 1.9823e-02 1.9075e-01 8.7398e-02 9.1826e-01 8.3771e-02 1.0054e+00 8.1451e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 328: 1.0251e+02 -4.0998e+00 -2.3162e+00 -4.0393e+00 -1.0100e+00 -4.5633e-02 4.2864e-03 1.9877e-05 8.2486e-02 1.9809e-02 1.9060e-01 8.7863e-02 9.1822e-01 8.3706e-02 1.0049e+00 8.1482e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 329: 1.0251e+02 -4.0998e+00 -2.3163e+00 -4.0392e+00 -1.0098e+00 -4.5698e-02 4.3097e-03 1.9869e-05 8.2469e-02 1.9795e-02 1.9047e-01 8.8220e-02 9.1805e-01 8.3704e-02 1.0045e+00 8.1502e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 330: 1.0251e+02 -4.0998e+00 -2.3168e+00 -4.0390e+00 -1.0099e+00 -4.5752e-02 4.3120e-03 1.9810e-05 8.2684e-02 1.9770e-02 1.9049e-01 8.8495e-02 9.1779e-01 8.3731e-02 1.0046e+00 8.1500e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 331: 1.0251e+02 -4.0998e+00 -2.3170e+00 -4.0390e+00 -1.0099e+00 -4.5957e-02 4.3052e-03 1.9736e-05 8.2748e-02 1.9734e-02 1.9034e-01 8.8651e-02 9.1818e-01 8.3707e-02 1.0050e+00 8.1489e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 332: 1.0251e+02 -4.0998e+00 -2.3171e+00 -4.0391e+00 -1.0098e+00 -4.5788e-02 4.2994e-03 1.9733e-05 8.2906e-02 1.9711e-02 1.9035e-01 8.8647e-02 9.1835e-01 8.3660e-02 1.0052e+00 8.1490e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 333: 1.0251e+02 -4.0998e+00 -2.3173e+00 -4.0392e+00 -1.0099e+00 -4.5316e-02 4.2822e-03 1.9667e-05 8.2967e-02 1.9695e-02 1.9041e-01 8.8729e-02 9.1832e-01 8.3666e-02 1.0056e+00 8.1484e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 334: 1.0251e+02 -4.0998e+00 -2.3179e+00 -4.0394e+00 -1.0097e+00 -4.4740e-02 4.2668e-03 1.9593e-05 8.3055e-02 1.9702e-02 1.9058e-01 8.8853e-02 9.1799e-01 8.3687e-02 1.0056e+00 8.1457e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 335: 1.0251e+02 -4.0998e+00 -2.3181e+00 -4.0395e+00 -1.0095e+00 -4.4451e-02 4.2558e-03 1.9535e-05 8.3023e-02 1.9762e-02 1.9027e-01 8.9035e-02 9.1828e-01 8.3673e-02 1.0052e+00 8.1469e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 336: 1.0251e+02 -4.0998e+00 -2.3178e+00 -4.0395e+00 -1.0098e+00 -4.4500e-02 4.2571e-03 1.9546e-05 8.3051e-02 1.9779e-02 1.9024e-01 8.9486e-02 9.1868e-01 8.3611e-02 1.0053e+00 8.1515e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 337: 1.0251e+02 -4.0998e+00 -2.3179e+00 -4.0396e+00 -1.0099e+00 -4.4018e-02 4.2494e-03 1.9584e-05 8.3206e-02 1.9764e-02 1.9011e-01 8.9643e-02 9.1871e-01 8.3659e-02 1.0056e+00 8.1531e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 338: 1.0251e+02 -4.0998e+00 -2.3180e+00 -4.0396e+00 -1.0101e+00 -4.3768e-02 4.2332e-03 1.9635e-05 8.3235e-02 1.9751e-02 1.9011e-01 8.9877e-02 9.1939e-01 8.3622e-02 1.0060e+00 8.1528e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 339: 1.0251e+02 -4.0998e+00 -2.3186e+00 -4.0397e+00 -1.0098e+00 -4.3605e-02 4.2237e-03 1.9638e-05 8.3611e-02 1.9725e-02 1.9014e-01 8.9946e-02 9.2025e-01 8.3580e-02 1.0064e+00 8.1528e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 340: 1.0251e+02 -4.0998e+00 -2.3190e+00 -4.0396e+00 -1.0097e+00 -4.3585e-02 4.2095e-03 1.9630e-05 8.3986e-02 1.9677e-02 1.9019e-01 8.9920e-02 9.2124e-01 8.3559e-02 1.0073e+00 8.1516e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 341: 1.0251e+02 -4.0998e+00 -2.3191e+00 -4.0398e+00 -1.0097e+00 -4.3238e-02 4.1994e-03 1.9636e-05 8.4311e-02 1.9683e-02 1.9023e-01 8.9809e-02 9.2179e-01 8.3517e-02 1.0079e+00 8.1498e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 342: 1.0251e+02 -4.0998e+00 -2.3194e+00 -4.0400e+00 -1.0097e+00 -4.2748e-02 4.1886e-03 1.9661e-05 8.4345e-02 1.9684e-02 1.9018e-01 8.9600e-02 9.2207e-01 8.3517e-02 1.0081e+00 8.1517e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 343: 1.0251e+02 -4.0998e+00 -2.3196e+00 -4.0402e+00 -1.0096e+00 -4.2336e-02 4.1813e-03 1.9615e-05 8.4331e-02 1.9666e-02 1.9016e-01 8.9379e-02 9.2231e-01 8.3534e-02 1.0083e+00 8.1548e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 344: 1.0251e+02 -4.0998e+00 -2.3197e+00 -4.0403e+00 -1.0097e+00 -4.2462e-02 4.1751e-03 1.9621e-05 8.4176e-02 1.9673e-02 1.8996e-01 8.9217e-02 9.2236e-01 8.3540e-02 1.0083e+00 8.1557e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 345: 1.0251e+02 -4.0998e+00 -2.3200e+00 -4.0403e+00 -1.0098e+00 -4.2327e-02 4.1705e-03 1.9552e-05 8.4159e-02 1.9684e-02 1.9017e-01 8.8957e-02 9.2232e-01 8.3511e-02 1.0085e+00 8.1566e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 346: 1.0251e+02 -4.0998e+00 -2.3200e+00 -4.0403e+00 -1.0097e+00 -4.2261e-02 4.1750e-03 1.9564e-05 8.4080e-02 1.9731e-02 1.9047e-01 8.8630e-02 9.2248e-01 8.3516e-02 1.0081e+00 8.1578e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 347: 1.0251e+02 -4.0999e+00 -2.3200e+00 -4.0403e+00 -1.0096e+00 -4.2296e-02 4.1883e-03 1.9634e-05 8.4231e-02 1.9747e-02 1.9061e-01 8.8399e-02 9.2250e-01 8.3557e-02 1.0075e+00 8.1580e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 348: 1.0251e+02 -4.0999e+00 -2.3199e+00 -4.0404e+00 -1.0096e+00 -4.2345e-02 4.2129e-03 1.9692e-05 8.4295e-02 1.9719e-02 1.9068e-01 8.8210e-02 9.2212e-01 8.3568e-02 1.0075e+00 8.1586e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 349: 1.0251e+02 -4.0999e+00 -2.3198e+00 -4.0404e+00 -1.0095e+00 -4.2617e-02 4.2066e-03 1.9720e-05 8.4289e-02 1.9731e-02 1.9054e-01 8.8147e-02 9.2185e-01 8.3565e-02 1.0070e+00 8.1590e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 350: 1.0251e+02 -4.0999e+00 -2.3196e+00 -4.0405e+00 -1.0093e+00 -4.2582e-02 4.2011e-03 1.9760e-05 8.4302e-02 1.9703e-02 1.9044e-01 8.8068e-02 9.2182e-01 8.3537e-02 1.0070e+00 8.1590e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 351: 1.0251e+02 -4.0998e+00 -2.3198e+00 -4.0405e+00 -1.0093e+00 -4.2377e-02 4.1970e-03 1.9750e-05 8.4587e-02 1.9708e-02 1.9045e-01 8.8008e-02 9.2169e-01 8.3507e-02 1.0067e+00 8.1584e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 352: 1.0251e+02 -4.0998e+00 -2.3201e+00 -4.0405e+00 -1.0091e+00 -4.2159e-02 4.1973e-03 1.9819e-05 8.4804e-02 1.9678e-02 1.9040e-01 8.7894e-02 9.2113e-01 8.3528e-02 1.0061e+00 8.1554e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 353: 1.0251e+02 -4.0998e+00 -2.3202e+00 -4.0405e+00 -1.0088e+00 -4.2123e-02 4.1968e-03 1.9855e-05 8.4945e-02 1.9634e-02 1.9049e-01 8.7941e-02 9.2108e-01 8.3500e-02 1.0058e+00 8.1548e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 354: 1.0251e+02 -4.0998e+00 -2.3204e+00 -4.0404e+00 -1.0087e+00 -4.2217e-02 4.1918e-03 1.9909e-05 8.5122e-02 1.9565e-02 1.9055e-01 8.7948e-02 9.2088e-01 8.3523e-02 1.0059e+00 8.1530e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 355: 1.0251e+02 -4.0998e+00 -2.3206e+00 -4.0404e+00 -1.0086e+00 -4.2057e-02 4.1853e-03 1.9973e-05 8.5389e-02 1.9505e-02 1.9057e-01 8.8109e-02 9.2100e-01 8.3496e-02 1.0058e+00 8.1520e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 356: 1.0251e+02 -4.0998e+00 -2.3209e+00 -4.0403e+00 -1.0084e+00 -4.1880e-02 4.1796e-03 2.0058e-05 8.5446e-02 1.9451e-02 1.9063e-01 8.7944e-02 9.2086e-01 8.3483e-02 1.0061e+00 8.1488e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 357: 1.0251e+02 -4.0998e+00 -2.3210e+00 -4.0404e+00 -1.0084e+00 -4.1565e-02 4.1858e-03 2.0131e-05 8.5481e-02 1.9391e-02 1.9072e-01 8.7879e-02 9.2119e-01 8.3465e-02 1.0066e+00 8.1468e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 358: 1.0251e+02 -4.0998e+00 -2.3213e+00 -4.0404e+00 -1.0084e+00 -4.1497e-02 4.1826e-03 2.0168e-05 8.5661e-02 1.9361e-02 1.9086e-01 8.7635e-02 9.2095e-01 8.3475e-02 1.0069e+00 8.1445e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 359: 1.0251e+02 -4.0997e+00 -2.3212e+00 -4.0405e+00 -1.0083e+00 -4.1127e-02 4.1993e-03 2.0188e-05 8.5904e-02 1.9347e-02 1.9078e-01 8.7558e-02 9.2087e-01 8.3451e-02 1.0068e+00 8.1461e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 360: 1.0251e+02 -4.0997e+00 -2.3215e+00 -4.0405e+00 -1.0082e+00 -4.0919e-02 4.2006e-03 2.0173e-05 8.6133e-02 1.9333e-02 1.9071e-01 8.7479e-02 9.2061e-01 8.3439e-02 1.0067e+00 8.1453e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 361: 1.0251e+02 -4.0997e+00 -2.3218e+00 -4.0406e+00 -1.0084e+00 -4.0317e-02 4.2013e-03 2.0253e-05 8.6558e-02 1.9351e-02 1.9075e-01 8.7309e-02 9.2060e-01 8.3425e-02 1.0069e+00 8.1464e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 362: 1.0251e+02 -4.0997e+00 -2.3221e+00 -4.0407e+00 -1.0086e+00 -3.9991e-02 4.2004e-03 2.0305e-05 8.6952e-02 1.9369e-02 1.9077e-01 8.7106e-02 9.2037e-01 8.3462e-02 1.0072e+00 8.1464e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 363: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0407e+00 -1.0086e+00 -3.9745e-02 4.1920e-03 2.0350e-05 8.7210e-02 1.9373e-02 1.9095e-01 8.6967e-02 9.2025e-01 8.3462e-02 1.0070e+00 8.1489e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 364: 1.0251e+02 -4.0997e+00 -2.3225e+00 -4.0407e+00 -1.0088e+00 -3.9585e-02 4.1826e-03 2.0355e-05 8.7449e-02 1.9353e-02 1.9099e-01 8.7119e-02 9.2081e-01 8.3468e-02 1.0070e+00 8.1514e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 365: 1.0251e+02 -4.0997e+00 -2.3224e+00 -4.0407e+00 -1.0088e+00 -3.9531e-02 4.1781e-03 2.0298e-05 8.7646e-02 1.9346e-02 1.9083e-01 8.6997e-02 9.2106e-01 8.3455e-02 1.0068e+00 8.1546e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 366: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0407e+00 -1.0088e+00 -3.9436e-02 4.1805e-03 2.0301e-05 8.7772e-02 1.9354e-02 1.9074e-01 8.7057e-02 9.2118e-01 8.3426e-02 1.0064e+00 8.1555e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 367: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0408e+00 -1.0088e+00 -3.9172e-02 4.1791e-03 2.0368e-05 8.7914e-02 1.9333e-02 1.9063e-01 8.6948e-02 9.2106e-01 8.3409e-02 1.0060e+00 8.1558e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 368: 1.0251e+02 -4.0997e+00 -2.3222e+00 -4.0410e+00 -1.0088e+00 -3.8640e-02 4.1857e-03 2.0343e-05 8.7937e-02 1.9334e-02 1.9051e-01 8.6857e-02 9.2143e-01 8.3379e-02 1.0058e+00 8.1564e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 369: 1.0251e+02 -4.0997e+00 -2.3223e+00 -4.0411e+00 -1.0088e+00 -3.8331e-02 4.1862e-03 2.0309e-05 8.7933e-02 1.9319e-02 1.9046e-01 8.6689e-02 9.2126e-01 8.3410e-02 1.0053e+00 8.1559e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 370: 1.0251e+02 -4.0997e+00 -2.3222e+00 -4.0413e+00 -1.0088e+00 -3.7984e-02 4.1921e-03 2.0301e-05 8.8082e-02 1.9313e-02 1.9050e-01 8.6622e-02 9.2101e-01 8.3424e-02 1.0049e+00 8.1559e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 371: 1.0251e+02 -4.0998e+00 -2.3222e+00 -4.0415e+00 -1.0087e+00 -3.7729e-02 4.1972e-03 2.0277e-05 8.8271e-02 1.9308e-02 1.9035e-01 8.6655e-02 9.2092e-01 8.3426e-02 1.0046e+00 8.1575e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 372: 1.0251e+02 -4.0998e+00 -2.3222e+00 -4.0414e+00 -1.0087e+00 -3.7571e-02 4.1922e-03 2.0292e-05 8.8651e-02 1.9317e-02 1.9025e-01 8.6528e-02 9.2126e-01 8.3440e-02 1.0046e+00 8.1576e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 373: 1.0251e+02 -4.0998e+00 -2.3223e+00 -4.0415e+00 -1.0087e+00 -3.7327e-02 4.1971e-03 2.0343e-05 8.8865e-02 1.9290e-02 1.9002e-01 8.6437e-02 9.2122e-01 8.3475e-02 1.0044e+00 8.1571e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 374: 1.0251e+02 -4.0998e+00 -2.3224e+00 -4.0415e+00 -1.0089e+00 -3.7275e-02 4.2072e-03 2.0450e-05 8.9078e-02 1.9306e-02 1.9002e-01 8.6224e-02 9.2111e-01 8.3480e-02 1.0047e+00 8.1569e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 375: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0415e+00 -1.0089e+00 -3.7080e-02 4.2062e-03 2.0489e-05 8.9178e-02 1.9320e-02 1.9016e-01 8.6141e-02 9.2116e-01 8.3483e-02 1.0047e+00 8.1586e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 376: 1.0251e+02 -4.0998e+00 -2.3230e+00 -4.0415e+00 -1.0089e+00 -3.7043e-02 4.2105e-03 2.0517e-05 8.9291e-02 1.9325e-02 1.9018e-01 8.6033e-02 9.2114e-01 8.3474e-02 1.0046e+00 8.1572e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 377: 1.0251e+02 -4.0998e+00 -2.3234e+00 -4.0414e+00 -1.0090e+00 -3.7302e-02 4.2097e-03 2.0524e-05 8.9438e-02 1.9333e-02 1.9012e-01 8.6018e-02 9.2123e-01 8.3476e-02 1.0046e+00 8.1545e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 378: 1.0251e+02 -4.0998e+00 -2.3234e+00 -4.0413e+00 -1.0089e+00 -3.7617e-02 4.2161e-03 2.0520e-05 8.9567e-02 1.9305e-02 1.9012e-01 8.6106e-02 9.2115e-01 8.3444e-02 1.0049e+00 8.1534e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 379: 1.0251e+02 -4.0998e+00 -2.3232e+00 -4.0412e+00 -1.0088e+00 -3.8039e-02 4.2231e-03 2.0484e-05 8.9704e-02 1.9276e-02 1.9015e-01 8.5914e-02 9.2060e-01 8.3438e-02 1.0048e+00 8.1532e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 380: 1.0251e+02 -4.0998e+00 -2.3229e+00 -4.0409e+00 -1.0088e+00 -3.8613e-02 4.2221e-03 2.0452e-05 8.9751e-02 1.9293e-02 1.9018e-01 8.5907e-02 9.2032e-01 8.3428e-02 1.0045e+00 8.1545e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 381: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.8992e-02 4.2177e-03 2.0475e-05 8.9641e-02 1.9314e-02 1.9014e-01 8.5978e-02 9.2015e-01 8.3429e-02 1.0040e+00 8.1535e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 382: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.9393e-02 4.2092e-03 2.0508e-05 8.9624e-02 1.9352e-02 1.9010e-01 8.5929e-02 9.2037e-01 8.3422e-02 1.0037e+00 8.1535e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 383: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0407e+00 -1.0089e+00 -3.9650e-02 4.2080e-03 2.0503e-05 8.9621e-02 1.9349e-02 1.9000e-01 8.5735e-02 9.2021e-01 8.3436e-02 1.0038e+00 8.1544e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 384: 1.0251e+02 -4.0998e+00 -2.3223e+00 -4.0407e+00 -1.0089e+00 -3.9709e-02 4.2111e-03 2.0489e-05 8.9690e-02 1.9347e-02 1.8985e-01 8.5516e-02 9.2025e-01 8.3420e-02 1.0037e+00 8.1541e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 385: 1.0251e+02 -4.0998e+00 -2.3225e+00 -4.0406e+00 -1.0087e+00 -3.9762e-02 4.2130e-03 2.0458e-05 8.9795e-02 1.9380e-02 1.8978e-01 8.5306e-02 9.2055e-01 8.3405e-02 1.0034e+00 8.1518e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 386: 1.0251e+02 -4.0998e+00 -2.3226e+00 -4.0407e+00 -1.0087e+00 -3.9801e-02 4.2117e-03 2.0473e-05 8.9838e-02 1.9386e-02 1.8986e-01 8.5045e-02 9.2034e-01 8.3388e-02 1.0036e+00 8.1512e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 387: 1.0251e+02 -4.0998e+00 -2.3228e+00 -4.0408e+00 -1.0088e+00 -3.9548e-02 4.2221e-03 2.0474e-05 8.9914e-02 1.9399e-02 1.9001e-01 8.4840e-02 9.2080e-01 8.3373e-02 1.0037e+00 8.1503e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 388: 1.0251e+02 -4.0998e+00 -2.3230e+00 -4.0408e+00 -1.0088e+00 -3.9408e-02 4.2272e-03 2.0464e-05 8.9977e-02 1.9383e-02 1.9000e-01 8.4644e-02 9.2070e-01 8.3377e-02 1.0034e+00 8.1494e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 389: 1.0250e+02 -4.0998e+00 -2.3229e+00 -4.0408e+00 -1.0087e+00 -3.9326e-02 4.2285e-03 2.0459e-05 8.9927e-02 1.9366e-02 1.9001e-01 8.4485e-02 9.2063e-01 8.3367e-02 1.0032e+00 8.1487e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 390: 1.0250e+02 -4.0998e+00 -2.3231e+00 -4.0409e+00 -1.0086e+00 -3.9130e-02 4.2286e-03 2.0423e-05 8.9894e-02 1.9331e-02 1.8996e-01 8.4434e-02 9.2054e-01 8.3339e-02 1.0032e+00 8.1481e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 391: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0410e+00 -1.0086e+00 -3.8976e-02 4.2242e-03 2.0419e-05 8.9782e-02 1.9299e-02 1.8992e-01 8.4344e-02 9.2089e-01 8.3320e-02 1.0032e+00 8.1480e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 392: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0409e+00 -1.0086e+00 -3.8856e-02 4.2179e-03 2.0396e-05 8.9773e-02 1.9263e-02 1.8984e-01 8.4469e-02 9.2084e-01 8.3309e-02 1.0034e+00 8.1489e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 393: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0409e+00 -1.0089e+00 -3.8820e-02 4.2135e-03 2.0375e-05 8.9746e-02 1.9259e-02 1.8972e-01 8.4731e-02 9.2088e-01 8.3310e-02 1.0031e+00 8.1481e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 394: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0410e+00 -1.0089e+00 -3.8759e-02 4.2123e-03 2.0382e-05 8.9791e-02 1.9271e-02 1.8958e-01 8.5075e-02 9.2064e-01 8.3316e-02 1.0028e+00 8.1483e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 395: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0410e+00 -1.0090e+00 -3.8565e-02 4.2179e-03 2.0420e-05 8.9844e-02 1.9279e-02 1.8948e-01 8.5286e-02 9.2070e-01 8.3311e-02 1.0027e+00 8.1499e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 396: 1.0250e+02 -4.0998e+00 -2.3233e+00 -4.0411e+00 -1.0092e+00 -3.8505e-02 4.2207e-03 2.0445e-05 8.9863e-02 1.9281e-02 1.8944e-01 8.5452e-02 9.2053e-01 8.3326e-02 1.0028e+00 8.1524e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 397: 1.0250e+02 -4.0998e+00 -2.3232e+00 -4.0411e+00 -1.0093e+00 -3.8366e-02 4.2115e-03 2.0410e-05 8.9792e-02 1.9287e-02 1.8938e-01 8.5649e-02 9.2063e-01 8.3351e-02 1.0034e+00 8.1519e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 398: 1.0250e+02 -4.0998e+00 -2.3234e+00 -4.0411e+00 -1.0093e+00 -3.8179e-02 4.2049e-03 2.0362e-05 8.9718e-02 1.9281e-02 1.8943e-01 8.5813e-02 9.2065e-01 8.3391e-02 1.0040e+00 8.1513e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 399: 1.0250e+02 -4.0998e+00 -2.3236e+00 -4.0411e+00 -1.0093e+00 -3.8020e-02 4.2015e-03 2.0320e-05 8.9743e-02 1.9283e-02 1.8934e-01 8.5899e-02 9.2056e-01 8.3426e-02 1.0045e+00 8.1500e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 400: 1.0250e+02 -4.0998e+00 -2.3237e+00 -4.0412e+00 -1.0093e+00 -3.7796e-02 4.2017e-03 2.0296e-05 8.9684e-02 1.9297e-02 1.8932e-01 8.5849e-02 9.2107e-01 8.3413e-02 1.0051e+00 8.1502e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 401: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0413e+00 -1.0093e+00 -3.7697e-02 4.1959e-03 2.0275e-05 8.9618e-02 1.9291e-02 1.8914e-01 8.5796e-02 9.2086e-01 8.3480e-02 1.0051e+00 8.1510e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 402: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0414e+00 -1.0093e+00 -3.7639e-02 4.1863e-03 2.0273e-05 8.9522e-02 1.9285e-02 1.8898e-01 8.5723e-02 9.2041e-01 8.3534e-02 1.0053e+00 8.1520e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 403: 1.0250e+02 -4.0998e+00 -2.3238e+00 -4.0415e+00 -1.0093e+00 -3.7634e-02 4.1878e-03 2.0250e-05 8.9456e-02 1.9288e-02 1.8895e-01 8.5791e-02 9.1990e-01 8.3549e-02 1.0055e+00 8.1545e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 404: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0416e+00 -1.0094e+00 -3.7581e-02 4.1854e-03 2.0292e-05 8.9326e-02 1.9326e-02 1.8902e-01 8.5928e-02 9.2016e-01 8.3542e-02 1.0053e+00 8.1565e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 405: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0094e+00 -3.7740e-02 4.1804e-03 2.0333e-05 8.9304e-02 1.9334e-02 1.8892e-01 8.6225e-02 9.1978e-01 8.3559e-02 1.0052e+00 8.1588e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 406: 1.0250e+02 -4.0999e+00 -2.3241e+00 -4.0415e+00 -1.0093e+00 -3.7837e-02 4.1866e-03 2.0375e-05 8.9281e-02 1.9322e-02 1.8906e-01 8.6421e-02 9.1972e-01 8.3556e-02 1.0051e+00 8.1596e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 407: 1.0250e+02 -4.0999e+00 -2.3240e+00 -4.0415e+00 -1.0092e+00 -3.8211e-02 4.1948e-03 2.0335e-05 8.9117e-02 1.9303e-02 1.8913e-01 8.6644e-02 9.1975e-01 8.3592e-02 1.0052e+00 8.1594e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 408: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0091e+00 -3.8144e-02 4.2081e-03 2.0320e-05 8.9057e-02 1.9287e-02 1.8912e-01 8.6825e-02 9.1992e-01 8.3572e-02 1.0054e+00 8.1577e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 409: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0415e+00 -1.0092e+00 -3.8261e-02 4.2186e-03 2.0295e-05 8.9007e-02 1.9339e-02 1.8923e-01 8.6869e-02 9.1991e-01 8.3568e-02 1.0053e+00 8.1578e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 410: 1.0250e+02 -4.0999e+00 -2.3239e+00 -4.0414e+00 -1.0093e+00 -3.8478e-02 4.2150e-03 2.0311e-05 8.9089e-02 1.9427e-02 1.8939e-01 8.7036e-02 9.2050e-01 8.3537e-02 1.0051e+00 8.1581e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 411: 1.0250e+02 -4.0999e+00 -2.3238e+00 -4.0413e+00 -1.0092e+00 -3.8732e-02 4.2116e-03 2.0289e-05 8.9015e-02 1.9467e-02 1.8939e-01 8.7005e-02 9.2025e-01 8.3538e-02 1.0049e+00 8.1581e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 412: 1.0250e+02 -4.0999e+00 -2.3238e+00 -4.0413e+00 -1.0092e+00 -3.8793e-02 4.2085e-03 2.0295e-05 8.9020e-02 1.9477e-02 1.8946e-01 8.7080e-02 9.2047e-01 8.3532e-02 1.0049e+00 8.1575e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 413: 1.0250e+02 -4.0999e+00 -2.3236e+00 -4.0412e+00 -1.0093e+00 -3.8937e-02 4.2069e-03 2.0288e-05 8.9121e-02 1.9495e-02 1.8939e-01 8.7203e-02 9.2043e-01 8.3528e-02 1.0046e+00 8.1581e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 414: 1.0250e+02 -4.0999e+00 -2.3233e+00 -4.0412e+00 -1.0093e+00 -3.9068e-02 4.2065e-03 2.0272e-05 8.9126e-02 1.9508e-02 1.8939e-01 8.7485e-02 9.2038e-01 8.3517e-02 1.0046e+00 8.1589e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 415: 1.0250e+02 -4.0999e+00 -2.3234e+00 -4.0412e+00 -1.0092e+00 -3.9299e-02 4.2117e-03 2.0277e-05 8.8971e-02 1.9564e-02 1.8955e-01 8.7734e-02 9.2051e-01 8.3502e-02 1.0048e+00 8.1575e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 416: 1.0250e+02 -4.0999e+00 -2.3232e+00 -4.0413e+00 -1.0092e+00 -3.9575e-02 4.2122e-03 2.0269e-05 8.8909e-02 1.9609e-02 1.8954e-01 8.7910e-02 9.2061e-01 8.3488e-02 1.0045e+00 8.1561e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 417: 1.0250e+02 -4.0999e+00 -2.3228e+00 -4.0412e+00 -1.0092e+00 -3.9794e-02 4.2133e-03 2.0289e-05 8.8845e-02 1.9606e-02 1.8949e-01 8.8036e-02 9.2065e-01 8.3481e-02 1.0047e+00 8.1558e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 418: 1.0250e+02 -4.0999e+00 -2.3226e+00 -4.0412e+00 -1.0092e+00 -4.0019e-02 4.2209e-03 2.0279e-05 8.8864e-02 1.9618e-02 1.8939e-01 8.8094e-02 9.2062e-01 8.3490e-02 1.0044e+00 8.1566e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 419: 1.0250e+02 -4.0999e+00 -2.3225e+00 -4.0411e+00 -1.0092e+00 -4.0090e-02 4.2242e-03 2.0258e-05 8.9089e-02 1.9644e-02 1.8924e-01 8.8285e-02 9.2082e-01 8.3484e-02 1.0040e+00 8.1567e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 420: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0410e+00 -1.0091e+00 -4.0260e-02 4.2298e-03 2.0249e-05 8.9215e-02 1.9640e-02 1.8919e-01 8.8683e-02 9.2127e-01 8.3454e-02 1.0041e+00 8.1564e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 421: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0410e+00 -1.0090e+00 -4.0359e-02 4.2292e-03 2.0289e-05 8.9366e-02 1.9642e-02 1.8928e-01 8.8905e-02 9.2154e-01 8.3452e-02 1.0038e+00 8.1572e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 422: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0410e+00 -1.0088e+00 -4.0380e-02 4.2311e-03 2.0289e-05 8.9318e-02 1.9636e-02 1.8934e-01 8.9025e-02 9.2137e-01 8.3486e-02 1.0039e+00 8.1562e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 423: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0411e+00 -1.0088e+00 -4.0256e-02 4.2283e-03 2.0277e-05 8.9324e-02 1.9645e-02 1.8923e-01 8.9305e-02 9.2129e-01 8.3484e-02 1.0038e+00 8.1565e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 424: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0412e+00 -1.0088e+00 -4.0075e-02 4.2333e-03 2.0245e-05 8.9193e-02 1.9657e-02 1.8914e-01 8.9480e-02 9.2122e-01 8.3487e-02 1.0039e+00 8.1587e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 425: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0413e+00 -1.0088e+00 -3.9950e-02 4.2360e-03 2.0257e-05 8.9170e-02 1.9644e-02 1.8924e-01 8.9622e-02 9.2104e-01 8.3492e-02 1.0042e+00 8.1599e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 426: 1.0250e+02 -4.0998e+00 -2.3226e+00 -4.0413e+00 -1.0088e+00 -3.9789e-02 4.2376e-03 2.0245e-05 8.9143e-02 1.9654e-02 1.8917e-01 8.9791e-02 9.2100e-01 8.3514e-02 1.0039e+00 8.1607e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 427: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0414e+00 -1.0087e+00 -3.9766e-02 4.2469e-03 2.0228e-05 8.9102e-02 1.9656e-02 1.8913e-01 9.0076e-02 9.2110e-01 8.3499e-02 1.0037e+00 8.1607e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 428: 1.0250e+02 -4.0998e+00 -2.3225e+00 -4.0414e+00 -1.0088e+00 -3.9662e-02 4.2522e-03 2.0205e-05 8.9151e-02 1.9669e-02 1.8912e-01 9.0312e-02 9.2102e-01 8.3483e-02 1.0036e+00 8.1599e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 429: 1.0250e+02 -4.0998e+00 -2.3225e+00 -4.0414e+00 -1.0089e+00 -3.9547e-02 4.2615e-03 2.0187e-05 8.9103e-02 1.9681e-02 1.8907e-01 9.0576e-02 9.2082e-01 8.3488e-02 1.0035e+00 8.1592e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 430: 1.0250e+02 -4.0998e+00 -2.3224e+00 -4.0414e+00 -1.0088e+00 -3.9593e-02 4.2613e-03 2.0159e-05 8.9075e-02 1.9692e-02 1.8894e-01 9.0762e-02 9.2073e-01 8.3487e-02 1.0035e+00 8.1603e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 431: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0413e+00 -1.0088e+00 -3.9929e-02 4.2668e-03 2.0112e-05 8.8982e-02 1.9682e-02 1.8901e-01 9.0997e-02 9.2043e-01 8.3487e-02 1.0036e+00 8.1604e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 432: 1.0250e+02 -4.0998e+00 -2.3223e+00 -4.0413e+00 -1.0088e+00 -4.0182e-02 4.2693e-03 2.0089e-05 8.8860e-02 1.9659e-02 1.8898e-01 9.1110e-02 9.2024e-01 8.3490e-02 1.0036e+00 8.1585e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 433: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0412e+00 -1.0088e+00 -4.0415e-02 4.2706e-03 2.0081e-05 8.8670e-02 1.9650e-02 1.8899e-01 9.1199e-02 9.1999e-01 8.3485e-02 1.0036e+00 8.1587e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 434: 1.0250e+02 -4.0998e+00 -2.3220e+00 -4.0412e+00 -1.0087e+00 -4.0405e-02 4.2661e-03 2.0060e-05 8.8576e-02 1.9667e-02 1.8897e-01 9.1180e-02 9.1998e-01 8.3468e-02 1.0034e+00 8.1594e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 435: 1.0250e+02 -4.0998e+00 -2.3218e+00 -4.0413e+00 -1.0087e+00 -4.0471e-02 4.2639e-03 2.0050e-05 8.8450e-02 1.9671e-02 1.8891e-01 9.1156e-02 9.1970e-01 8.3469e-02 1.0033e+00 8.1602e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 436: 1.0250e+02 -4.0998e+00 -2.3216e+00 -4.0413e+00 -1.0086e+00 -4.0478e-02 4.2614e-03 2.0025e-05 8.8470e-02 1.9677e-02 1.8892e-01 9.1234e-02 9.1948e-01 8.3484e-02 1.0033e+00 8.1608e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 437: 1.0250e+02 -4.0998e+00 -2.3214e+00 -4.0413e+00 -1.0086e+00 -4.0648e-02 4.2569e-03 2.0021e-05 8.8378e-02 1.9694e-02 1.8896e-01 9.1289e-02 9.1946e-01 8.3486e-02 1.0034e+00 8.1608e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 438: 1.0250e+02 -4.0998e+00 -2.3214e+00 -4.0413e+00 -1.0085e+00 -4.0807e-02 4.2559e-03 2.0029e-05 8.8244e-02 1.9704e-02 1.8898e-01 9.1352e-02 9.1920e-01 8.3494e-02 1.0034e+00 8.1604e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 439: 1.0250e+02 -4.0998e+00 -2.3215e+00 -4.0413e+00 -1.0084e+00 -4.0814e-02 4.2472e-03 2.0035e-05 8.8064e-02 1.9736e-02 1.8905e-01 9.1469e-02 9.1900e-01 8.3510e-02 1.0032e+00 8.1602e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 440: 1.0250e+02 -4.0998e+00 -2.3216e+00 -4.0414e+00 -1.0084e+00 -4.0845e-02 4.2385e-03 2.0044e-05 8.7953e-02 1.9775e-02 1.8906e-01 9.1482e-02 9.1902e-01 8.3529e-02 1.0029e+00 8.1605e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 441: 1.0250e+02 -4.0998e+00 -2.3218e+00 -4.0415e+00 -1.0084e+00 -4.0561e-02 4.2293e-03 2.0096e-05 8.7978e-02 1.9848e-02 1.8914e-01 9.1431e-02 9.1890e-01 8.3545e-02 1.0026e+00 8.1618e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 442: 1.0250e+02 -4.0998e+00 -2.3219e+00 -4.0415e+00 -1.0085e+00 -4.0297e-02 4.2190e-03 2.0140e-05 8.8016e-02 1.9884e-02 1.8912e-01 9.1373e-02 9.1910e-01 8.3556e-02 1.0025e+00 8.1632e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 443: 1.0250e+02 -4.0998e+00 -2.3222e+00 -4.0415e+00 -1.0086e+00 -4.0124e-02 4.2172e-03 2.0182e-05 8.8183e-02 1.9921e-02 1.8920e-01 9.1354e-02 9.1928e-01 8.3555e-02 1.0023e+00 8.1646e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 444: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0084e+00 -4.0120e-02 4.2226e-03 2.0208e-05 8.8142e-02 1.9980e-02 1.8916e-01 9.1269e-02 9.1934e-01 8.3540e-02 1.0020e+00 8.1653e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 445: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0083e+00 -4.0180e-02 4.2279e-03 2.0283e-05 8.8188e-02 2.0009e-02 1.8925e-01 9.1096e-02 9.1924e-01 8.3538e-02 1.0017e+00 8.1644e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 446: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0417e+00 -1.0084e+00 -4.0083e-02 4.2373e-03 2.0357e-05 8.8255e-02 2.0030e-02 1.8937e-01 9.0921e-02 9.1921e-01 8.3535e-02 1.0015e+00 8.1652e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 447: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0417e+00 -1.0083e+00 -4.0032e-02 4.2591e-03 2.0418e-05 8.8322e-02 2.0055e-02 1.8931e-01 9.0741e-02 9.1928e-01 8.3527e-02 1.0011e+00 8.1662e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 448: 1.0250e+02 -4.0999e+00 -2.3224e+00 -4.0417e+00 -1.0083e+00 -4.0042e-02 4.2759e-03 2.0499e-05 8.8372e-02 2.0083e-02 1.8935e-01 9.0554e-02 9.1942e-01 8.3524e-02 1.0010e+00 8.1661e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 449: 1.0250e+02 -4.0999e+00 -2.3224e+00 -4.0417e+00 -1.0083e+00 -4.0219e-02 4.2779e-03 2.0525e-05 8.8377e-02 2.0104e-02 1.8937e-01 9.0424e-02 9.1970e-01 8.3510e-02 1.0009e+00 8.1654e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 450: 1.0250e+02 -4.0999e+00 -2.3223e+00 -4.0416e+00 -1.0084e+00 -4.0390e-02 4.2779e-03 2.0520e-05 8.8387e-02 2.0120e-02 1.8939e-01 9.0277e-02 9.1991e-01 8.3489e-02 1.0010e+00 8.1662e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 451: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0085e+00 -4.0403e-02 4.2785e-03 2.0554e-05 8.8442e-02 2.0130e-02 1.8934e-01 9.0032e-02 9.2001e-01 8.3485e-02 1.0011e+00 8.1676e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 452: 1.0250e+02 -4.0999e+00 -2.3220e+00 -4.0415e+00 -1.0084e+00 -4.0503e-02 4.2730e-03 2.0537e-05 8.8507e-02 2.0135e-02 1.8926e-01 8.9777e-02 9.2031e-01 8.3473e-02 1.0013e+00 8.1671e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 453: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0084e+00 -4.0716e-02 4.2650e-03 2.0525e-05 8.8565e-02 2.0168e-02 1.8921e-01 8.9653e-02 9.2030e-01 8.3473e-02 1.0010e+00 8.1665e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 454: 1.0250e+02 -4.0999e+00 -2.3221e+00 -4.0415e+00 -1.0083e+00 -4.0900e-02 4.2583e-03 2.0505e-05 8.8572e-02 2.0194e-02 1.8912e-01 8.9524e-02 9.2039e-01 8.3457e-02 1.0009e+00 8.1658e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 455: 1.0250e+02 -4.0999e+00 -2.3220e+00 -4.0415e+00 -1.0083e+00 -4.0930e-02 4.2524e-03 2.0495e-05 8.8643e-02 2.0246e-02 1.8914e-01 8.9416e-02 9.2035e-01 8.3454e-02 1.0006e+00 8.1655e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 456: 1.0250e+02 -4.0999e+00 -2.3218e+00 -4.0414e+00 -1.0084e+00 -4.1008e-02 4.2455e-03 2.0482e-05 8.8831e-02 2.0290e-02 1.8904e-01 8.9438e-02 9.2042e-01 8.3448e-02 1.0005e+00 8.1672e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 457: 1.0250e+02 -4.0999e+00 -2.3216e+00 -4.0414e+00 -1.0085e+00 -4.1073e-02 4.2376e-03 2.0479e-05 8.8831e-02 2.0310e-02 1.8893e-01 8.9411e-02 9.2049e-01 8.3438e-02 1.0005e+00 8.1677e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 458: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0085e+00 -4.1036e-02 4.2288e-03 2.0479e-05 8.8894e-02 2.0311e-02 1.8879e-01 8.9378e-02 9.2055e-01 8.3419e-02 1.0006e+00 8.1689e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 459: 1.0250e+02 -4.0999e+00 -2.3216e+00 -4.0414e+00 -1.0085e+00 -4.1084e-02 4.2296e-03 2.0472e-05 8.8976e-02 2.0290e-02 1.8876e-01 8.9365e-02 9.2056e-01 8.3404e-02 1.0007e+00 8.1678e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 460: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0084e+00 -4.1065e-02 4.2257e-03 2.0473e-05 8.8978e-02 2.0254e-02 1.8871e-01 8.9287e-02 9.2061e-01 8.3386e-02 1.0007e+00 8.1663e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 461: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0084e+00 -4.1142e-02 4.2254e-03 2.0441e-05 8.8952e-02 2.0238e-02 1.8864e-01 8.9236e-02 9.2067e-01 8.3359e-02 1.0007e+00 8.1670e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 462: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0413e+00 -1.0083e+00 -4.1199e-02 4.2230e-03 2.0409e-05 8.9161e-02 2.0235e-02 1.8852e-01 8.9179e-02 9.2070e-01 8.3339e-02 1.0005e+00 8.1686e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 463: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0413e+00 -1.0084e+00 -4.1131e-02 4.2191e-03 2.0397e-05 8.9356e-02 2.0251e-02 1.8850e-01 8.9138e-02 9.2098e-01 8.3308e-02 1.0003e+00 8.1688e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 464: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0084e+00 -4.0937e-02 4.2187e-03 2.0395e-05 8.9553e-02 2.0237e-02 1.8848e-01 8.9097e-02 9.2108e-01 8.3293e-02 1.0001e+00 8.1684e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 465: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0086e+00 -4.0873e-02 4.2226e-03 2.0374e-05 8.9675e-02 2.0210e-02 1.8854e-01 8.9045e-02 9.2115e-01 8.3282e-02 1.0002e+00 8.1678e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 466: 1.0250e+02 -4.0999e+00 -2.3213e+00 -4.0414e+00 -1.0085e+00 -4.1046e-02 4.2312e-03 2.0379e-05 8.9703e-02 2.0232e-02 1.8852e-01 8.9031e-02 9.2100e-01 8.3294e-02 9.9982e-01 8.1665e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 467: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0414e+00 -1.0086e+00 -4.1081e-02 4.2382e-03 2.0421e-05 8.9802e-02 2.0266e-02 1.8851e-01 8.9175e-02 9.2124e-01 8.3271e-02 9.9943e-01 8.1671e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 468: 1.0250e+02 -4.0999e+00 -2.3215e+00 -4.0414e+00 -1.0085e+00 -4.1107e-02 4.2412e-03 2.0446e-05 8.9937e-02 2.0281e-02 1.8857e-01 8.9238e-02 9.2125e-01 8.3255e-02 9.9912e-01 8.1659e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 469: 1.0250e+02 -4.0999e+00 -2.3214e+00 -4.0414e+00 -1.0084e+00 -4.1269e-02 4.2380e-03 2.0449e-05 8.9938e-02 2.0285e-02 1.8867e-01 8.9378e-02 9.2144e-01 8.3225e-02 9.9906e-01 8.1651e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 470: 1.0250e+02 -4.0999e+00 -2.3212e+00 -4.0413e+00 -1.0083e+00 -4.1552e-02 4.2384e-03 2.0437e-05 8.9924e-02 2.0280e-02 1.8878e-01 8.9520e-02 9.2149e-01 8.3205e-02 9.9880e-01 8.1648e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 471: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0412e+00 -1.0082e+00 -4.2096e-02 4.2375e-03 2.0433e-05 8.9875e-02 2.0267e-02 1.8880e-01 8.9608e-02 9.2149e-01 8.3221e-02 9.9869e-01 8.1642e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 472: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0411e+00 -1.0081e+00 -4.2380e-02 4.2446e-03 2.0435e-05 8.9823e-02 2.0262e-02 1.8885e-01 8.9602e-02 9.2156e-01 8.3233e-02 9.9868e-01 8.1643e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 473: 1.0250e+02 -4.0999e+00 -2.3210e+00 -4.0410e+00 -1.0080e+00 -4.2522e-02 4.2486e-03 2.0429e-05 8.9793e-02 2.0231e-02 1.8877e-01 8.9608e-02 9.2177e-01 8.3210e-02 9.9901e-01 8.1637e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 474: 1.0250e+02 -4.0999e+00 -2.3209e+00 -4.0410e+00 -1.0079e+00 -4.2640e-02 4.2536e-03 2.0403e-05 8.9731e-02 2.0213e-02 1.8876e-01 8.9632e-02 9.2177e-01 8.3192e-02 9.9942e-01 8.1632e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 475: 1.0250e+02 -4.0999e+00 -2.3208e+00 -4.0409e+00 -1.0079e+00 -4.2882e-02 4.2576e-03 2.0375e-05 8.9666e-02 2.0190e-02 1.8866e-01 8.9718e-02 9.2160e-01 8.3218e-02 9.9931e-01 8.1622e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 476: 1.0250e+02 -4.0999e+00 -2.3207e+00 -4.0409e+00 -1.0080e+00 -4.2983e-02 4.2599e-03 2.0368e-05 8.9563e-02 2.0171e-02 1.8859e-01 8.9777e-02 9.2162e-01 8.3236e-02 9.9932e-01 8.1620e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 477: 1.0250e+02 -4.0999e+00 -2.3205e+00 -4.0410e+00 -1.0081e+00 -4.3022e-02 4.2570e-03 2.0364e-05 8.9440e-02 2.0166e-02 1.8860e-01 8.9785e-02 9.2171e-01 8.3236e-02 9.9940e-01 8.1633e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 478: 1.0250e+02 -4.0999e+00 -2.3203e+00 -4.0410e+00 -1.0080e+00 -4.3129e-02 4.2505e-03 2.0371e-05 8.9374e-02 2.0151e-02 1.8859e-01 8.9826e-02 9.2171e-01 8.3224e-02 9.9970e-01 8.1620e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 479: 1.0250e+02 -4.1000e+00 -2.3201e+00 -4.0410e+00 -1.0080e+00 -4.3186e-02 4.2440e-03 2.0373e-05 8.9355e-02 2.0133e-02 1.8858e-01 8.9837e-02 9.2168e-01 8.3214e-02 9.9991e-01 8.1621e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 480: 1.0250e+02 -4.1000e+00 -2.3198e+00 -4.0410e+00 -1.0080e+00 -4.3477e-02 4.2424e-03 2.0440e-05 8.9311e-02 2.0121e-02 1.8857e-01 8.9848e-02 9.2158e-01 8.3221e-02 9.9995e-01 8.1627e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 481: 1.0250e+02 -4.1000e+00 -2.3194e+00 -4.0410e+00 -1.0079e+00 -4.3647e-02 4.2358e-03 2.0479e-05 8.9315e-02 2.0096e-02 1.8851e-01 8.9865e-02 9.2159e-01 8.3197e-02 1.0002e+00 8.1642e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 482: 1.0250e+02 -4.1000e+00 -2.3188e+00 -4.0409e+00 -1.0079e+00 -4.3909e-02 4.2370e-03 2.0551e-05 8.9382e-02 2.0085e-02 1.8840e-01 8.9799e-02 9.2147e-01 8.3229e-02 1.0001e+00 8.1656e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 483: 1.0250e+02 -4.1000e+00 -2.3189e+00 -4.0409e+00 -1.0078e+00 -4.4169e-02 4.2467e-03 2.0587e-05 8.9377e-02 2.0054e-02 1.8838e-01 8.9943e-02 9.2130e-01 8.3237e-02 1.0003e+00 8.1650e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 484: 1.0250e+02 -4.1000e+00 -2.3188e+00 -4.0408e+00 -1.0078e+00 -4.4346e-02 4.2627e-03 2.0605e-05 8.9450e-02 2.0020e-02 1.8840e-01 9.0090e-02 9.2114e-01 8.3237e-02 1.0004e+00 8.1639e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 485: 1.0250e+02 -4.1000e+00 -2.3185e+00 -4.0408e+00 -1.0079e+00 -4.4414e-02 4.2737e-03 2.0594e-05 8.9541e-02 1.9999e-02 1.8842e-01 9.0237e-02 9.2116e-01 8.3227e-02 1.0004e+00 8.1641e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 486: 1.0250e+02 -4.1000e+00 -2.3183e+00 -4.0408e+00 -1.0080e+00 -4.4572e-02 4.2902e-03 2.0581e-05 8.9733e-02 1.9978e-02 1.8837e-01 9.0412e-02 9.2098e-01 8.3224e-02 1.0003e+00 8.1642e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 487: 1.0250e+02 -4.1000e+00 -2.3182e+00 -4.0407e+00 -1.0081e+00 -4.4698e-02 4.2979e-03 2.0560e-05 8.9822e-02 1.9954e-02 1.8827e-01 9.0744e-02 9.2114e-01 8.3212e-02 1.0003e+00 8.1644e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 488: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0081e+00 -4.4892e-02 4.3035e-03 2.0549e-05 8.9849e-02 1.9928e-02 1.8816e-01 9.1000e-02 9.2118e-01 8.3206e-02 1.0003e+00 8.1644e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 489: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0081e+00 -4.5037e-02 4.2987e-03 2.0515e-05 8.9843e-02 1.9906e-02 1.8815e-01 9.1260e-02 9.2116e-01 8.3190e-02 1.0001e+00 8.1633e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 490: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0405e+00 -1.0081e+00 -4.5139e-02 4.2930e-03 2.0508e-05 8.9827e-02 1.9887e-02 1.8814e-01 9.1545e-02 9.2114e-01 8.3178e-02 9.9991e-01 8.1624e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 491: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0405e+00 -1.0081e+00 -4.5107e-02 4.2871e-03 2.0490e-05 8.9765e-02 1.9855e-02 1.8814e-01 9.1702e-02 9.2089e-01 8.3179e-02 9.9986e-01 8.1624e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 492: 1.0250e+02 -4.1000e+00 -2.3178e+00 -4.0405e+00 -1.0080e+00 -4.5192e-02 4.2818e-03 2.0470e-05 8.9791e-02 1.9831e-02 1.8810e-01 9.1846e-02 9.2086e-01 8.3164e-02 9.9977e-01 8.1630e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 493: 1.0250e+02 -4.1000e+00 -2.3179e+00 -4.0406e+00 -1.0078e+00 -4.4968e-02 4.2782e-03 2.0452e-05 8.9797e-02 1.9804e-02 1.8806e-01 9.1987e-02 9.2080e-01 8.3146e-02 9.9982e-01 8.1627e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 494: 1.0250e+02 -4.1000e+00 -2.3180e+00 -4.0406e+00 -1.0078e+00 -4.4773e-02 4.2766e-03 2.0453e-05 8.9696e-02 1.9781e-02 1.8805e-01 9.2096e-02 9.2057e-01 8.3148e-02 9.9999e-01 8.1611e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 495: 1.0250e+02 -4.1000e+00 -2.3181e+00 -4.0408e+00 -1.0078e+00 -4.4647e-02 4.2798e-03 2.0446e-05 8.9661e-02 1.9763e-02 1.8804e-01 9.2155e-02 9.2039e-01 8.3137e-02 9.9999e-01 8.1599e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 496: 1.0250e+02 -4.1000e+00 -2.3182e+00 -4.0408e+00 -1.0079e+00 -4.4482e-02 4.2851e-03 2.0434e-05 8.9630e-02 1.9750e-02 1.8796e-01 9.2258e-02 9.2042e-01 8.3124e-02 1.0000e+00 8.1601e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 497: 1.0250e+02 -4.1000e+00 -2.3184e+00 -4.0409e+00 -1.0079e+00 -4.4175e-02 4.2866e-03 2.0423e-05 8.9656e-02 1.9743e-02 1.8789e-01 9.2225e-02 9.2017e-01 8.3126e-02 1.0002e+00 8.1616e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 498: 1.0250e+02 -4.1000e+00 -2.3187e+00 -4.0409e+00 -1.0079e+00 -4.3826e-02 4.2847e-03 2.0406e-05 8.9587e-02 1.9730e-02 1.8781e-01 9.2143e-02 9.2017e-01 8.3156e-02 1.0002e+00 8.1613e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 499: 1.0250e+02 -4.1000e+00 -2.3190e+00 -4.0409e+00 -1.0078e+00 -4.3529e-02 4.2806e-03 2.0397e-05 8.9653e-02 1.9712e-02 1.8779e-01 9.2107e-02 9.2028e-01 8.3172e-02 1.0004e+00 8.1607e-02</span> -<span class="r-out co"><span class="r-pr">#></span> 500: 1.0250e+02 -4.1000e+00 -2.3193e+00 -4.0409e+00 -1.0077e+00 -4.3241e-02 4.2787e-03 2.0390e-05 8.9759e-02 1.9689e-02 1.8773e-01 9.2021e-02 9.2029e-01 8.3203e-02 1.0006e+00 8.1613e-02</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="co"># The following takes a very long time but gives</span></span> -<span class="r-in"><span class="va">f_nlmixr_dfop_sfo_focei</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/nlmixr/man/nlmixr.html" class="external-link">nlmixr</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span>, est <span class="op">=</span> <span class="st">"focei"</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> parameter labels from comments are typically ignored in non-interactive mode</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BBBB;">ℹ</span> Need to run with the source intact to parse comments</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → creating full model...</span> -<span class="r-msg co"><span class="r-pr">#></span> → pruning branches (`if`/`else`)...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → loading into <span style="color: #0000BB;">symengine</span> environment...</span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate jacobian</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate sensitivities</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(f)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → calculate ∂(R²)/∂(η)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in inner model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in EBE model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling inner model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → finding duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → optimizing duplicate expressions in FD model...</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling EBE model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> → compiling events FD model...</span> -<span class="r-msg co"><span class="r-pr">#></span> </span> -<span class="r-msg co"><span class="r-pr">#></span> <span style="color: #00BB00;">✔</span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Needed Covariates:</span> -<span class="r-out co"><span class="r-pr">#></span> [1] "CMT"</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="font-weight: bold;">Key:</span> U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> F: Forward difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> C: Central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> M: Mixed forward and central difference gradient approximation</span> -<span class="r-out co"><span class="r-pr">#></span> Unscaled parameters for Omegas=chol(solve(omega));</span> -<span class="r-out co"><span class="r-pr">#></span> Diagonals are transformed, as specified by foceiControl(diagXform=)</span> -<span class="r-out co"><span class="r-pr">#></span> |-----+---------------+-----------+-----------+-----------+-----------|</span> -<span class="r-out co"><span class="r-pr">#></span> | #| Objective Fun | parent_0 | log_k_m1 |f_parent_qlogis | log_k1 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| log_k2 | g_qlogis | sigma_low | rsd_high |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| o1 | o2 | o3 | o4 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| o5 | o6 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 1</span>| 496.69520 | 1.000 | -1.000 | -0.9393 | -0.9673 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.000 | -0.9214 | -0.9072 | -0.9199 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9082 | -0.8909 | -0.8969 | -0.8991 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8928 | -0.8991 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 496.6952 | 100.0 | -4.100 | -0.9400 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.100 | -0.01100 | 0.7300 | 0.06700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6756 | 1.581 | 1.265 | 1.151 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.151 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 496.6952</span> | 100.0 | 0.01657 | 0.2809 | 0.09072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01657 | 0.4973 | 0.7300 | 0.06700 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6756 | 1.581 | 1.265 | 1.151 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.477 | 1.151 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | G| Gill Diff. | -72.99 | -3.907 | -0.8109 | 0.02803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.841 | 0.006841 | -22.18 | -32.78 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.538 | -16.93 | -12.84 | -12.77 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.02 | -9.608 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 2</span>| 1346.5436 | 1.823 | -0.9559 | -0.9301 | -0.9677 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9792 | -0.9215 | -0.6570 | -0.5501 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9482 | -0.6999 | -0.7521 | -0.7551 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7234 | -0.7907 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 1346.5436 | 182.3 | -4.056 | -0.9314 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.079 | -0.01100 | 0.8213 | 0.07939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6486 | 1.883 | 1.449 | 1.317 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.728 | 1.276 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 1346.5436</span> | 182.3 | 0.01732 | 0.2826 | 0.09069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01692 | 0.4972 | 0.8213 | 0.07939 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6486 | 1.883 | 1.449 | 1.317 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.728 | 1.276 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 3</span>| 512.48246 | 1.082 | -0.9956 | -0.9384 | -0.9674 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9979 | -0.9214 | -0.8822 | -0.8830 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9122 | -0.8718 | -0.8824 | -0.8847 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8759 | -0.8883 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 512.48246 | 108.2 | -4.096 | -0.9391 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7391 | 0.06824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6729 | 1.611 | 1.284 | 1.167 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.502 | 1.163 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 512.48246</span> | 108.2 | 0.01665 | 0.2811 | 0.09072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01661 | 0.4973 | 0.7391 | 0.06824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6729 | 1.611 | 1.284 | 1.167 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.502 | 1.163 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 4</span>| 495.95762 | 1.015 | -0.9992 | -0.9391 | -0.9673 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9996 | -0.9214 | -0.9027 | -0.9133 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9090 | -0.8874 | -0.8943 | -0.8965 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8898 | -0.8972 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.95762 | 101.5 | -4.099 | -0.9398 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.100 | -0.01100 | 0.7316 | 0.06722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6751 | 1.587 | 1.269 | 1.154 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.95762</span> | 101.5 | 0.01659 | 0.2809 | 0.09072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01658 | 0.4973 | 0.7316 | 0.06722 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6751 | 1.587 | 1.269 | 1.154 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.482 | 1.153 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.81 | -3.013 | -0.08916 | -0.3303 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.914 | 0.005472 | -23.39 | -29.38 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.465 | -17.07 | -12.49 | -12.74 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.23 | -9.735 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 5</span>| 495.32815 | 1.003 | -0.9984 | -0.9391 | -0.9673 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9991 | -0.9214 | -0.8962 | -0.9051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9099 | -0.8826 | -0.8908 | -0.8930 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8855 | -0.8944 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 495.32815 | 100.3 | -4.098 | -0.9398 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.099 | -0.01100 | 0.7340 | 0.06750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6745 | 1.594 | 1.273 | 1.158 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.156 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 495.32815</span> | 100.3 | 0.01660 | 0.2809 | 0.09073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01659 | 0.4973 | 0.7340 | 0.06750 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6745 | 1.594 | 1.273 | 1.158 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.488 | 1.156 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -47.70 | -3.739 | -0.6694 | -0.04580 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.870 | 0.006670 | -22.76 | -30.26 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.613 | -16.75 | -12.29 | -12.38 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.09 | -9.486 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 6</span>| 494.72051 | 1.016 | -0.9974 | -0.9389 | -0.9672 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9986 | -0.9214 | -0.8902 | -0.8971 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9109 | -0.8782 | -0.8876 | -0.8897 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8816 | -0.8919 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.72051 | 101.6 | -4.097 | -0.9397 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.099 | -0.01100 | 0.7362 | 0.06777 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6738 | 1.601 | 1.277 | 1.162 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.159 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.72051</span> | 101.6 | 0.01662 | 0.2810 | 0.09073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01660 | 0.4973 | 0.7362 | 0.06777 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6738 | 1.601 | 1.277 | 1.162 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.494 | 1.159 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 48.34 | -2.939 | -0.03847 | -0.3608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.945 | 0.005434 | -20.90 | -26.17 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.821 | -17.00 | -12.53 | -12.70 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.56 | -9.587 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 7</span>| 494.15722 | 1.003 | -0.9966 | -0.9389 | -0.9671 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9981 | -0.9214 | -0.8845 | -0.8900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9119 | -0.8736 | -0.8842 | -0.8863 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8773 | -0.8893 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 494.15722 | 100.3 | -4.097 | -0.9396 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7383 | 0.06800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6731 | 1.608 | 1.282 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.500 | 1.162 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 494.15722</span> | 100.3 | 0.01663 | 0.2810 | 0.09074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01660 | 0.4973 | 0.7383 | 0.06800 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6731 | 1.608 | 1.282 | 1.166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.500 | 1.162 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.36 | -3.770 | -0.7003 | -0.03307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.882 | 0.006830 | -20.02 | -28.64 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.020 | -16.49 | -12.31 | -12.33 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.87 | -9.319 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 8</span>| 493.49185 | 1.015 | -0.9955 | -0.9387 | -0.9671 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9975 | -0.9214 | -0.8787 | -0.8818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9128 | -0.8688 | -0.8806 | -0.8827 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8730 | -0.8866 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 493.49185 | 101.5 | -4.096 | -0.9395 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.098 | -0.01100 | 0.7404 | 0.06828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6725 | 1.616 | 1.286 | 1.170 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.507 | 1.165 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 493.49185</span> | 101.5 | 0.01665 | 0.2810 | 0.09074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01661 | 0.4973 | 0.7404 | 0.06828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6725 | 1.616 | 1.286 | 1.170 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.507 | 1.165 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 41.03 | -2.976 | -0.07989 | -0.3421 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.950 | 0.005619 | -20.95 | -25.58 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.377 | -16.59 | -11.95 | -12.23 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.73 | -9.398 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 9</span>| 492.95463 | 1.003 | -0.9946 | -0.9387 | -0.9670 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9969 | -0.9215 | -0.8725 | -0.8742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9138 | -0.8639 | -0.8771 | -0.8790 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8686 | -0.8839 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 492.95463 | 100.3 | -4.095 | -0.9394 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.097 | -0.01100 | 0.7427 | 0.06853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6718 | 1.624 | 1.291 | 1.174 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.513 | 1.168 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.95463</span> | 100.3 | 0.01666 | 0.2810 | 0.09075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01662 | 0.4973 | 0.7427 | 0.06853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6718 | 1.624 | 1.291 | 1.174 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.513 | 1.168 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.97 | -3.772 | -0.7121 | -0.02926 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.890 | 0.006985 | -18.86 | -26.85 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.866 | -16.28 | -11.70 | -11.82 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.59 | -9.132 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 10</span>| 492.31444 | 1.015 | -0.9935 | -0.9385 | -0.9670 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9964 | -0.9215 | -0.8668 | -0.8662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9147 | -0.8589 | -0.8735 | -0.8755 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8642 | -0.8811 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 492.31444 | 101.5 | -4.094 | -0.9393 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.096 | -0.01100 | 0.7448 | 0.06880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6712 | 1.632 | 1.295 | 1.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.520 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 492.31444</span> | 101.5 | 0.01668 | 0.2810 | 0.09075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01663 | 0.4972 | 0.7448 | 0.06880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6712 | 1.632 | 1.295 | 1.178 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.520 | 1.172 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 40.47 | -2.944 | -0.07505 | -0.3464 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.962 | 0.005707 | -18.58 | -22.75 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.454 | -16.50 | -11.93 | -12.14 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -15.04 | -9.193 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 11</span>| 491.79472 | 1.003 | -0.9926 | -0.9385 | -0.9669 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9957 | -0.9215 | -0.8609 | -0.8590 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9158 | -0.8537 | -0.8697 | -0.8716 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8594 | -0.8781 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.79472 | 100.3 | -4.093 | -0.9392 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.096 | -0.01100 | 0.7469 | 0.06904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6705 | 1.640 | 1.300 | 1.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.175 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.79472</span> | 100.3 | 0.01670 | 0.2811 | 0.09076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01664 | 0.4972 | 0.7469 | 0.06904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6705 | 1.640 | 1.300 | 1.183 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.527 | 1.175 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.84 | -3.756 | -0.7183 | -0.02810 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.902 | 0.007122 | -19.51 | -25.13 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.711 | -16.03 | -11.73 | -11.80 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.28 | -8.965 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 12</span>| 491.12641 | 1.014 | -0.9913 | -0.9383 | -0.9669 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9951 | -0.9215 | -0.8546 | -0.8511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9167 | -0.8483 | -0.8658 | -0.8677 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8546 | -0.8752 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 491.12641 | 101.4 | -4.091 | -0.9390 | -2.400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.095 | -0.01100 | 0.7492 | 0.06931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6699 | 1.648 | 1.305 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.534 | 1.178 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 491.12641</span> | 101.4 | 0.01672 | 0.2811 | 0.09076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01665 | 0.4972 | 0.7492 | 0.06931 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6699 | 1.648 | 1.305 | 1.187 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.534 | 1.178 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.57 | -2.950 | -0.1076 | -0.3310 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.967 | 0.005897 | -18.06 | -21.71 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.154 | -16.24 | -11.62 | -11.87 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.73 | -8.995 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 13</span>| 490.65951 | 1.002 | -0.9903 | -0.9382 | -0.9668 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9944 | -0.9215 | -0.8485 | -0.8438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9178 | -0.8429 | -0.8619 | -0.8637 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8496 | -0.8721 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.65951 | 100.2 | -4.090 | -0.9390 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.094 | -0.01100 | 0.7514 | 0.06955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6692 | 1.657 | 1.310 | 1.192 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.541 | 1.182 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.65951</span> | 100.2 | 0.01673 | 0.2811 | 0.09077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01667 | 0.4972 | 0.7514 | 0.06955 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6692 | 1.657 | 1.310 | 1.192 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.541 | 1.182 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.76 | -3.759 | -0.7472 | -0.01668 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.908 | 0.007323 | -16.70 | -21.90 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.094 | -15.72 | -11.38 | -11.47 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.04 | -8.745 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 14</span>| 490.01300 | 1.014 | -0.9891 | -0.9380 | -0.9667 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9937 | -0.9215 | -0.8428 | -0.8366 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9189 | -0.8372 | -0.8579 | -0.8596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8446 | -0.8690 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 490.013 | 101.4 | -4.089 | -0.9388 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.094 | -0.01100 | 0.7535 | 0.06979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6684 | 1.666 | 1.315 | 1.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.549 | 1.186 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 490.013</span> | 101.4 | 0.01676 | 0.2811 | 0.09077 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01668 | 0.4972 | 0.7535 | 0.06979 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6684 | 1.666 | 1.315 | 1.196 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.549 | 1.186 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 34.25 | -2.890 | -0.09666 | -0.3362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.973 | 0.006003 | -17.09 | -20.19 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 3.007 | -15.95 | -11.25 | -11.56 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.42 | -8.788 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 15</span>| 489.51603 | 1.003 | -0.9880 | -0.9380 | -0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9930 | -0.9215 | -0.8366 | -0.8294 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9200 | -0.8313 | -0.8537 | -0.8553 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8392 | -0.8658 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 489.51603 | 100.3 | -4.088 | -0.9388 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.093 | -0.01100 | 0.7558 | 0.07003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6677 | 1.675 | 1.320 | 1.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.556 | 1.189 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 489.51603</span> | 100.3 | 0.01677 | 0.2812 | 0.09078 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01669 | 0.4972 | 0.7558 | 0.07003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6677 | 1.675 | 1.320 | 1.201 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.556 | 1.189 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -45.29 | -3.673 | -0.7179 | -0.03084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.907 | 0.007423 | -17.34 | -21.86 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.565 | -15.52 | -11.05 | -11.19 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.28 | -8.545 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 16</span>| 488.89410 | 1.014 | -0.9866 | -0.9377 | -0.9666 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9922 | -0.9215 | -0.8304 | -0.8220 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9210 | -0.8254 | -0.8495 | -0.8510 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8337 | -0.8625 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.8941 | 101.4 | -4.087 | -0.9385 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.092 | -0.01100 | 0.7580 | 0.07028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6670 | 1.685 | 1.325 | 1.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.565 | 1.193 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.8941</span> | 101.4 | 0.01680 | 0.2812 | 0.09079 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01670 | 0.4972 | 0.7580 | 0.07028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6670 | 1.685 | 1.325 | 1.206 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.565 | 1.193 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 32.56 | -2.827 | -0.09853 | -0.3366 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.968 | 0.006143 | -15.42 | -18.16 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.733 | -15.52 | -10.94 | -11.25 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.13 | -8.583 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 17</span>| 488.48678 | 1.002 | -0.9855 | -0.9377 | -0.9664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9915 | -0.9215 | -0.8246 | -0.8152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9220 | -0.8195 | -0.8454 | -0.8468 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8284 | -0.8593 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 488.48678 | 100.2 | -4.086 | -0.9385 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.091 | -0.01100 | 0.7601 | 0.07051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 1.694 | 1.331 | 1.211 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.572 | 1.197 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 488.48678</span> | 100.2 | 0.01681 | 0.2812 | 0.09080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01671 | 0.4972 | 0.7601 | 0.07051 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 1.694 | 1.331 | 1.211 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.572 | 1.197 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -50.86 | -3.681 | -0.7723 |-0.0007467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.892 | 0.007742 | -16.40 | -20.55 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.306 | -15.16 | -10.65 | -10.82 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -14.00 | -8.331 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 18</span>| 487.81394 | 1.012 | -0.9841 | -0.9374 | -0.9664 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9907 | -0.9215 | -0.8186 | -0.8083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9229 | -0.8132 | -0.8411 | -0.8424 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8225 | -0.8558 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.81394 | 101.2 | -4.084 | -0.9383 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.091 | -0.01100 | 0.7623 | 0.07074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6657 | 1.704 | 1.336 | 1.216 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.581 | 1.201 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.81394</span> | 101.2 | 0.01684 | 0.2812 | 0.09080 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01673 | 0.4972 | 0.7623 | 0.07074 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6657 | 1.704 | 1.336 | 1.216 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.581 | 1.201 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.73 | -2.818 | -0.1513 | -0.3103 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.952 | 0.006413 | -14.43 | -16.89 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.774 | -15.21 | -10.56 | -10.91 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.80 | -8.354 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 19</span>| 487.41354 | 1.002 | -0.9829 | -0.9374 | -0.9663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9898 | -0.9215 | -0.8126 | -0.8013 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9240 | -0.8068 | -0.8367 | -0.8378 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8167 | -0.8523 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 487.41354 | 100.2 | -4.083 | -0.9382 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.090 | -0.01100 | 0.7645 | 0.07098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6649 | 1.714 | 1.342 | 1.221 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.590 | 1.205 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 487.41354</span> | 100.2 | 0.01686 | 0.2813 | 0.09082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01674 | 0.4972 | 0.7645 | 0.07098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6649 | 1.714 | 1.342 | 1.221 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.590 | 1.205 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.04 | -3.605 | -0.7738 | -0.005231 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.885 | 0.007887 | -13.75 | -19.14 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.153 | -14.90 | -10.33 | -10.54 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.68 | -8.125 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 20</span>| 486.77105 | 1.012 | -0.9814 | -0.9371 | -0.9662 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9889 | -0.9215 | -0.8076 | -0.7947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9250 | -0.7999 | -0.8321 | -0.8330 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8104 | -0.8486 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 486.77105 | 101.2 | -4.081 | -0.9380 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.089 | -0.01100 | 0.7664 | 0.07119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6643 | 1.725 | 1.347 | 1.227 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.599 | 1.209 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.77105</span> | 101.2 | 0.01688 | 0.2813 | 0.09082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01676 | 0.4972 | 0.7664 | 0.07119 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6643 | 1.725 | 1.347 | 1.227 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.599 | 1.209 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.27 | -2.713 | -0.1438 | -0.3142 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.939 | 0.006562 | -14.18 | -16.12 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.525 | -14.86 | -10.17 | -10.57 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.46 | -8.131 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 21</span>| 486.40106 | 1.002 | -0.9802 | -0.9371 | -0.9661 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9881 | -0.9215 | -0.8015 | -0.7878 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9261 | -0.7935 | -0.8277 | -0.8285 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8046 | -0.8452 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 486.40106 | 100.2 | -4.080 | -0.9379 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.088 | -0.01100 | 0.7686 | 0.07143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6635 | 1.735 | 1.353 | 1.232 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.608 | 1.213 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 486.40106</span> | 100.2 | 0.01690 | 0.2813 | 0.09083 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01677 | 0.4972 | 0.7686 | 0.07143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6635 | 1.735 | 1.353 | 1.232 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.608 | 1.213 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -49.43 | -3.533 | -0.7907 | 0.002583 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.861 | 0.008122 | -12.85 | -17.77 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.313 | -14.52 | -9.868 | -10.18 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.34 | -7.899 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 22</span>| 485.77865 | 1.012 | -0.9786 | -0.9368 | -0.9660 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9871 | -0.9215 | -0.7966 | -0.7818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9271 | -0.7864 | -0.8231 | -0.8237 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7980 | -0.8414 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.77865 | 101.2 | -4.079 | -0.9376 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.087 | -0.01100 | 0.7704 | 0.07163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6629 | 1.746 | 1.359 | 1.238 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.617 | 1.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.77865</span> | 101.2 | 0.01693 | 0.2814 | 0.09084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01679 | 0.4972 | 0.7704 | 0.07163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6629 | 1.746 | 1.359 | 1.238 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.617 | 1.217 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.77 | -2.587 | -0.1355 | -0.3176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.913 | 0.006717 | -13.39 | -15.00 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.211 | -14.53 | -9.747 | -10.22 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -13.16 | -7.915 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 23</span>| 485.42886 | 1.002 | -0.9775 | -0.9367 | -0.9659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9862 | -0.9215 | -0.7907 | -0.7751 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9281 | -0.7799 | -0.8187 | -0.8190 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7921 | -0.8378 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 485.42886 | 100.2 | -4.077 | -0.9376 | -2.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.086 | -0.01100 | 0.7725 | 0.07185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6622 | 1.757 | 1.364 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.626 | 1.221 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 485.42886</span> | 100.2 | 0.01695 | 0.2814 | 0.09085 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01680 | 0.4972 | 0.7725 | 0.07185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6622 | 1.757 | 1.364 | 1.243 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.626 | 1.221 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.95 | -3.431 | -0.7980 | 0.007511 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.828 | 0.008340 | -12.05 | -16.59 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.177 | -14.27 | -9.567 | -9.843 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.98 | -7.655 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 24</span>| 484.82183 | 1.012 | -0.9759 | -0.9364 | -0.9658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9852 | -0.9215 | -0.7861 | -0.7697 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9290 | -0.7723 | -0.8141 | -0.8141 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7852 | -0.8339 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.82183 | 101.2 | -4.076 | -0.9373 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.085 | -0.01100 | 0.7742 | 0.07203 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6616 | 1.769 | 1.370 | 1.249 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.636 | 1.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.82183</span> | 101.2 | 0.01698 | 0.2814 | 0.09086 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01682 | 0.4972 | 0.7742 | 0.07203 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6616 | 1.769 | 1.370 | 1.249 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.636 | 1.226 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.05 | -2.460 | -0.1372 | -0.3150 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.875 | 0.006918 | -12.51 | -13.87 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.059 | -14.26 | -9.441 | -9.910 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.81 | -7.688 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 25</span>| 484.49026 | 1.002 | -0.9747 | -0.9363 | -0.9656 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9843 | -0.9215 | -0.7802 | -0.7632 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9300 | -0.7655 | -0.8095 | -0.8093 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7791 | -0.8302 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 484.49026 | 100.2 | -4.075 | -0.9372 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.084 | -0.01100 | 0.7764 | 0.07225 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6609 | 1.779 | 1.376 | 1.254 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.645 | 1.230 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 484.49026</span> | 100.2 | 0.01700 | 0.2815 | 0.09087 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01684 | 0.4972 | 0.7764 | 0.07225 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6609 | 1.779 | 1.376 | 1.254 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.645 | 1.230 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -48.40 | -3.314 | -0.8046 | 0.01082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.785 | 0.008564 | -11.34 | -13.90 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.095 | -13.95 | -9.157 | -9.483 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.66 | -7.448 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 26</span>| 483.91316 | 1.012 | -0.9731 | -0.9360 | -0.9656 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9832 | -0.9215 | -0.7758 | -0.7593 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9309 | -0.7575 | -0.8048 | -0.8042 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7719 | -0.8261 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.91316 | 101.2 | -4.073 | -0.9369 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.083 | -0.01100 | 0.7780 | 0.07238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6603 | 1.792 | 1.382 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.656 | 1.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.91316</span> | 101.2 | 0.01702 | 0.2815 | 0.09088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01685 | 0.4972 | 0.7780 | 0.07238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6603 | 1.792 | 1.382 | 1.260 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.656 | 1.235 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.71 | -2.295 | -0.1241 | -0.3190 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.824 | 0.007081 | -13.14 | -14.20 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.713 | -13.92 | -9.049 | -9.560 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.44 | -7.439 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 27</span>| 483.53972 | 1.003 | -0.9719 | -0.9359 | -0.9654 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9822 | -0.9215 | -0.7695 | -0.7529 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9317 | -0.7501 | -0.8002 | -0.7993 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7653 | -0.8222 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.53972 | 100.3 | -4.072 | -0.9368 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.082 | -0.01100 | 0.7803 | 0.07259 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6598 | 1.804 | 1.388 | 1.266 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.666 | 1.239 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.53972</span> | 100.3 | 0.01705 | 0.2815 | 0.09089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01687 | 0.4972 | 0.7803 | 0.07259 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6598 | 1.804 | 1.388 | 1.266 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.666 | 1.239 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -41.33 | -3.086 | -0.7421 | -0.01550 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.732 | 0.008667 | -12.24 | -14.31 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.879 | -13.57 | -8.704 | -9.151 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.31 | -7.231 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 28</span>| 483.02129 | 1.012 | -0.9704 | -0.9356 | -0.9653 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9811 | -0.9215 | -0.7639 | -0.7482 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9323 | -0.7422 | -0.7957 | -0.7943 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7582 | -0.8182 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 483.02129 | 101.2 | -4.070 | -0.9365 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.081 | -0.01100 | 0.7823 | 0.07275 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6594 | 1.816 | 1.393 | 1.271 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.676 | 1.244 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 483.02129</span> | 101.2 | 0.01707 | 0.2816 | 0.09090 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01689 | 0.4972 | 0.7823 | 0.07275 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6594 | 1.816 | 1.393 | 1.271 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.676 | 1.244 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 24.99 | -2.064 | -0.07177 | -0.3414 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.768 | 0.007186 | -12.35 | -13.09 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.619 | -13.63 | -8.749 | -9.199 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -12.40 | -7.209 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 29</span>| 482.63111 | 1.003 | -0.9692 | -0.9355 | -0.9651 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9800 | -0.9215 | -0.7579 | -0.7429 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9329 | -0.7344 | -0.7911 | -0.7893 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7510 | -0.8142 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.63111 | 100.3 | -4.069 | -0.9364 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.080 | -0.01100 | 0.7845 | 0.07293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6589 | 1.829 | 1.399 | 1.277 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.687 | 1.249 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.63111</span> | 100.3 | 0.01709 | 0.2816 | 0.09092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01691 | 0.4972 | 0.7845 | 0.07293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6589 | 1.829 | 1.399 | 1.277 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.687 | 1.249 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.55 | -2.873 | -0.6941 | -0.03251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.664 | 0.008820 | -11.56 | -13.31 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.468 | -13.22 | -8.319 | -8.815 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.93 | -7.014 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 30</span>| 482.15860 | 1.013 | -0.9679 | -0.9352 | -0.9650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9789 | -0.9215 | -0.7525 | -0.7387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9332 | -0.7261 | -0.7866 | -0.7843 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7435 | -0.8100 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 482.1586 | 101.3 | -4.068 | -0.9361 | -2.398 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.079 | -0.01100 | 0.7865 | 0.07307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6587 | 1.842 | 1.405 | 1.283 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.698 | 1.253 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 482.1586</span> | 101.3 | 0.01711 | 0.2817 | 0.09093 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01693 | 0.4972 | 0.7865 | 0.07307 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6587 | 1.842 | 1.405 | 1.283 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.698 | 1.253 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 26.18 | -1.853 | -0.03641 | -0.3540 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.697 | 0.007343 | -10.35 | -10.94 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.762 | -13.15 | -8.194 | -8.841 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.73 | -7.013 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 31</span>| 481.77253 | 1.004 | -0.9667 | -0.9350 | -0.9648 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9778 | -0.9215 | -0.7477 | -0.7350 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9339 | -0.7174 | -0.7818 | -0.7789 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7358 | -0.8055 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.77253 | 100.4 | -4.067 | -0.9360 | -2.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.078 | -0.01100 | 0.7882 | 0.07320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6583 | 1.855 | 1.411 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.709 | 1.259 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.77253</span> | 100.4 | 0.01713 | 0.2817 | 0.09095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01695 | 0.4972 | 0.7882 | 0.07320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6583 | 1.855 | 1.411 | 1.289 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.709 | 1.259 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -33.42 | -2.468 | -0.6588 | -0.04495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.582 | 0.009000 | -9.278 | -10.93 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 2.073 | -12.89 | -7.995 | -8.451 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.53 | -6.784 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 32</span>| 481.33405 | 1.012 | -0.9656 | -0.9347 | -0.9646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9766 | -0.9215 | -0.7446 | -0.7329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9352 | -0.7079 | -0.7769 | -0.7733 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7275 | -0.8008 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 481.33405 | 101.2 | -4.066 | -0.9357 | -2.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.077 | -0.01100 | 0.7894 | 0.07326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6574 | 1.870 | 1.417 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.721 | 1.264 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 481.33405</span> | 101.2 | 0.01715 | 0.2818 | 0.09096 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01697 | 0.4972 | 0.7894 | 0.07326 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6574 | 1.870 | 1.417 | 1.296 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.721 | 1.264 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.32 | -1.710 | -0.03967 | -0.3452 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.599 | 0.007614 | -9.890 | -10.44 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.650 | -12.78 | -7.841 | -8.441 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.31 | -6.748 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 33</span>| 480.95912 | 1.004 | -0.9646 | -0.9346 | -0.9644 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9754 | -0.9215 | -0.7406 | -0.7300 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | -0.6985 | -0.7720 | -0.7677 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7193 | -0.7960 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.95912 | 100.4 | -4.065 | -0.9356 | -2.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.075 | -0.01100 | 0.7908 | 0.07336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 1.885 | 1.424 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.734 | 1.270 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.95912</span> | 100.4 | 0.01717 | 0.2818 | 0.09098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01699 | 0.4972 | 0.7908 | 0.07336 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 1.885 | 1.424 | 1.302 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.734 | 1.270 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -30.38 | -2.273 | -0.6168 | -0.05646 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.481 | 0.009185 | -8.899 | -11.86 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.510 | -12.49 | -7.578 | -8.069 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -11.13 | -6.546 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 34</span>| 480.53887 | 1.012 | -0.9637 | -0.9342 | -0.9642 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9743 | -0.9216 | -0.7379 | -0.7267 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9369 | -0.6888 | -0.7673 | -0.7623 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7109 | -0.7912 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.53887 | 101.2 | -4.064 | -0.9352 | -2.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.074 | -0.01100 | 0.7918 | 0.07347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.901 | 1.429 | 1.308 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.746 | 1.275 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.53887</span> | 101.2 | 0.01719 | 0.2819 | 0.09100 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01700 | 0.4972 | 0.7918 | 0.07347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.901 | 1.429 | 1.308 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.746 | 1.275 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.40 | -1.545 | -0.009684 | -0.3499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.497 | 0.007817 | -10.78 | -11.16 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.267 | -12.36 | -7.423 | -8.042 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.90 | -6.497 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 35</span>| 480.15983 | 1.005 | -0.9631 | -0.9341 | -0.9640 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9733 | -0.9216 | -0.7332 | -0.7223 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9371 | -0.6793 | -0.7629 | -0.7571 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7029 | -0.7866 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.15983 | 100.5 | -4.063 | -0.9351 | -2.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.073 | -0.01100 | 0.7935 | 0.07362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6561 | 1.916 | 1.435 | 1.314 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.758 | 1.280 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.15983</span> | 100.5 | 0.01720 | 0.2819 | 0.09102 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01702 | 0.4972 | 0.7935 | 0.07362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6561 | 1.916 | 1.435 | 1.314 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.758 | 1.280 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.57 | -2.381 | -0.5845 | -0.05882 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.378 | 0.009420 | -9.960 | -11.12 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.408 | -12.08 | -7.201 | -7.708 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.66 | -6.274 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 36</span>| 479.76525 | 1.013 | -0.9621 | -0.9338 | -0.9638 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9724 | -0.9216 | -0.7274 | -0.7189 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9370 | -0.6698 | -0.7590 | -0.7523 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6950 | -0.7821 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.76525 | 101.3 | -4.062 | -0.9349 | -2.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.072 | -0.01100 | 0.7956 | 0.07373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.931 | 1.440 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.770 | 1.286 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.76525</span> | 101.3 | 0.01721 | 0.2819 | 0.09104 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01704 | 0.4972 | 0.7956 | 0.07373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 1.931 | 1.440 | 1.320 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.770 | 1.286 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 25.60 | -1.145 | 0.04744 | -0.3638 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.405 | 0.007969 | -8.937 | -9.159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.481 | -11.97 | -7.076 | -7.721 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.46 | -6.241 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 37</span>| 479.40619 | 1.005 | -0.9617 | -0.9337 | -0.9635 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9714 | -0.9216 | -0.7231 | -0.7171 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6597 | -0.7546 | -0.7470 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6867 | -0.7774 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.40619 | 100.5 | -4.062 | -0.9348 | -2.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.071 | -0.01100 | 0.7972 | 0.07380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.947 | 1.445 | 1.326 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.782 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.40619</span> | 100.5 | 0.01722 | 0.2820 | 0.09107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01705 | 0.4972 | 0.7972 | 0.07380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.947 | 1.445 | 1.326 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.782 | 1.291 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.68 | -2.255 | -0.5492 | -0.06756 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.289 | 0.009576 | -8.071 | -10.65 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.114 | -11.68 | -6.840 | -7.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.30 | -6.055 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 38</span>| 479.03445 | 1.012 | -0.9610 | -0.9335 | -0.9633 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9705 | -0.9216 | -0.7212 | -0.7148 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6492 | -0.7503 | -0.7416 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6779 | -0.7724 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 479.03445 | 101.2 | -4.061 | -0.9345 | -2.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.071 | -0.01100 | 0.7979 | 0.07387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.963 | 1.451 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.795 | 1.297 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 479.03445</span> | 101.2 | 0.01723 | 0.2820 | 0.09109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01707 | 0.4972 | 0.7979 | 0.07387 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.963 | 1.451 | 1.332 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.795 | 1.297 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.12 | -1.081 | 0.03630 | -0.3485 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.311 | 0.008233 | -8.610 | -8.856 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.385 | -11.53 | -6.694 | -7.351 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -10.05 | -5.987 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 39</span>| 478.70046 | 1.005 | -0.9607 | -0.9334 | -0.9629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9697 | -0.9216 | -0.7185 | -0.7124 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9378 | -0.6386 | -0.7461 | -0.7363 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6692 | -0.7674 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.70046 | 100.5 | -4.061 | -0.9345 | -2.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.070 | -0.01100 | 0.7989 | 0.07395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 1.980 | 1.456 | 1.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.808 | 1.302 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.70046</span> | 100.5 | 0.01724 | 0.2820 | 0.09112 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01708 | 0.4972 | 0.7989 | 0.07395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 1.980 | 1.456 | 1.338 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.808 | 1.302 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.51 | -2.193 | -0.5308 | -0.05813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.191 | 0.009843 | -9.246 | -10.25 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.049 | -11.25 | -6.459 | -7.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.842 | -5.790 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 40</span>| 478.33460 | 1.012 | -0.9602 | -0.9332 | -0.9627 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9690 | -0.9216 | -0.7136 | -0.7111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9376 | -0.6278 | -0.7425 | -0.7314 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6607 | -0.7626 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.3346 | 101.2 | -4.060 | -0.9343 | -2.395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.069 | -0.01100 | 0.8007 | 0.07400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.997 | 1.461 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.820 | 1.308 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.3346</span> | 101.2 | 0.01724 | 0.2821 | 0.09114 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01709 | 0.4972 | 0.8007 | 0.07400 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6558 | 1.997 | 1.461 | 1.344 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.820 | 1.308 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 20.00 | -1.246 | 0.04282 | -0.3358 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.228 | 0.008460 | -8.250 | -8.533 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.305 | -11.09 | -6.335 | -6.999 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.637 | -5.739 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 41</span>| 478.02904 | 1.005 | -0.9595 | -0.9333 | -0.9623 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9683 | -0.9217 | -0.7087 | -0.7092 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9377 | -0.6173 | -0.7388 | -0.7264 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6523 | -0.7577 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 478.02904 | 100.5 | -4.060 | -0.9343 | -2.395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.068 | -0.01100 | 0.8025 | 0.07406 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 2.014 | 1.466 | 1.350 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.833 | 1.314 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 478.02904</span> | 100.5 | 0.01726 | 0.2820 | 0.09117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01711 | 0.4972 | 0.8025 | 0.07406 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6557 | 2.014 | 1.466 | 1.350 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.833 | 1.314 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.91 | -2.133 | -0.5430 | -0.03427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.114 | 0.01012 | -7.324 | -9.914 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9278 | -10.81 | -6.119 | -6.673 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.457 | -5.557 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 42</span>| 477.67480 | 1.012 | -0.9587 | -0.9331 | -0.9620 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9677 | -0.9217 | -0.7077 | -0.7075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9374 | -0.6060 | -0.7354 | -0.7215 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6433 | -0.7527 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.6748 | 101.2 | -4.059 | -0.9342 | -2.395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.068 | -0.01100 | 0.8028 | 0.07412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.032 | 1.470 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.846 | 1.319 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.6748</span> | 101.2 | 0.01727 | 0.2821 | 0.09120 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01712 | 0.4972 | 0.8028 | 0.07412 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.032 | 1.470 | 1.355 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.846 | 1.319 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 17.58 | -1.074 | 0.03251 | -0.3151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.162 | 0.008688 | -9.226 | -9.481 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9303 | -10.65 | -6.004 | -6.660 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.223 | -5.492 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 43</span>| 477.36674 | 1.005 | -0.9586 | -0.9332 | -0.9617 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9672 | -0.9217 | -0.7028 | -0.7029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9362 | -0.5954 | -0.7323 | -0.7170 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6350 | -0.7479 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.36674 | 100.5 | -4.059 | -0.9343 | -2.394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.067 | -0.01100 | 0.8046 | 0.07427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6567 | 2.048 | 1.474 | 1.361 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.858 | 1.325 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.36674</span> | 100.5 | 0.01727 | 0.2821 | 0.09123 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01713 | 0.4972 | 0.8046 | 0.07427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6567 | 2.048 | 1.474 | 1.361 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.858 | 1.325 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -26.86 | -1.999 | -0.5088 | -0.02993 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.056 | 0.01029 | -6.930 | -7.943 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.123 | -10.40 | -5.776 | -6.354 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -9.032 | -5.321 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 44</span>| 477.05158 | 1.012 | -0.9583 | -0.9331 | -0.9614 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9667 | -0.9217 | -0.6985 | -0.7029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9357 | -0.5841 | -0.7296 | -0.7125 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6265 | -0.7430 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 477.05158 | 101.2 | -4.058 | -0.9342 | -2.394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.067 | -0.01100 | 0.8062 | 0.07427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.066 | 1.477 | 1.366 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.871 | 1.331 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 477.05158</span> | 101.2 | 0.01728 | 0.2821 | 0.09126 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01713 | 0.4972 | 0.8062 | 0.07427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.066 | 1.477 | 1.366 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.871 | 1.331 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 21.59 | -0.9080 | 0.1072 | -0.3377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.120 | 0.008656 | -8.076 | -8.919 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8940 | -10.23 | -5.724 | -6.385 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.830 | -5.273 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 45</span>| 476.75116 | 1.006 | -0.9582 | -0.9333 | -0.9610 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9662 | -0.9217 | -0.6961 | -0.7025 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9353 | -0.5723 | -0.7265 | -0.7076 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6174 | -0.7378 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.75116 | 100.6 | -4.058 | -0.9343 | -2.394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.066 | -0.01100 | 0.8070 | 0.07428 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.085 | 1.481 | 1.371 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.884 | 1.337 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.75116</span> | 100.6 | 0.01728 | 0.2820 | 0.09129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01714 | 0.4972 | 0.8070 | 0.07428 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.085 | 1.481 | 1.371 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.884 | 1.337 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -19.26 | -1.806 | -0.3949 | -0.06769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | 0.01017 | -6.717 | -7.715 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.115 | -9.949 | -5.529 | -6.080 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.599 | -5.083 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 46</span>| 476.47529 | 1.013 | -0.9577 | -0.9333 | -0.9608 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9657 | -0.9218 | -0.6941 | -0.7020 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9354 | -0.5606 | -0.7233 | -0.7027 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6086 | -0.7326 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.47529 | 101.3 | -4.058 | -0.9343 | -2.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.066 | -0.01100 | 0.8078 | 0.07430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.103 | 1.485 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.897 | 1.342 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.47529</span> | 101.3 | 0.01729 | 0.2820 | 0.09132 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01715 | 0.4972 | 0.8078 | 0.07430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6573 | 2.103 | 1.485 | 1.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.897 | 1.342 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 23.23 | -0.7393 | 0.1467 | -0.3435 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.063 | 0.008714 | -6.650 | -7.604 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.072 | -9.778 | -5.421 | -6.068 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.413 | -5.023 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 47</span>| 476.20958 | 1.007 | -0.9575 | -0.9335 | -0.9604 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9651 | -0.9218 | -0.6949 | -0.7035 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9364 | -0.5488 | -0.7198 | -0.6977 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5996 | -0.7274 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 476.20958 | 100.7 | -4.058 | -0.9345 | -2.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.065 | -0.01100 | 0.8075 | 0.07425 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 2.122 | 1.490 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.910 | 1.349 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 476.20958</span> | 100.7 | 0.01729 | 0.2820 | 0.09135 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01716 | 0.4972 | 0.8075 | 0.07425 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6566 | 2.122 | 1.490 | 1.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.910 | 1.349 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.91 | -1.652 | -0.3580 | -0.07063 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9392 | 0.01022 | -6.706 | -7.708 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9788 | -9.498 | -5.202 | -5.742 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -8.208 | -4.851 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 48</span>| 475.96032 | 1.013 | -0.9572 | -0.9335 | -0.9601 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9647 | -0.9218 | -0.6944 | -0.7034 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9370 | -0.5368 | -0.7166 | -0.6928 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5905 | -0.7221 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.96032 | 101.3 | -4.057 | -0.9346 | -2.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.065 | -0.01100 | 0.8077 | 0.07425 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 2.141 | 1.494 | 1.388 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.924 | 1.355 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.96032</span> | 101.3 | 0.01730 | 0.2820 | 0.09138 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8077 | 0.07425 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6562 | 2.141 | 1.494 | 1.388 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.924 | 1.355 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 22.21 | -0.6469 | 0.1490 | -0.3297 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9912 | 0.008804 | -6.697 | -7.730 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.011 | -9.295 | -5.014 | -5.737 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.990 | -4.768 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 49</span>| 475.69232 | 1.007 | -0.9579 | -0.9338 | -0.9597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9645 | -0.9219 | -0.6939 | -0.7032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9375 | -0.5243 | -0.7149 | -0.6885 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5813 | -0.7168 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.69232 | 100.7 | -4.058 | -0.9348 | -2.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01100 | 0.8078 | 0.07426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.161 | 1.496 | 1.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.937 | 1.361 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.69232</span> | 100.7 | 0.01729 | 0.2819 | 0.09141 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8078 | 0.07426 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6559 | 2.161 | 1.496 | 1.393 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.937 | 1.361 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -16.63 | -1.703 | -0.3428 | -0.06069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9074 | 0.01024 | -7.409 | -9.759 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6668 | -9.063 | -4.970 | -5.451 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.786 | -4.607 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 50</span>| 475.41012 | 1.012 | -0.9580 | -0.9340 | -0.9594 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9645 | -0.9219 | -0.6912 | -0.6928 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9358 | -0.5138 | -0.7150 | -0.6862 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5743 | -0.7128 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.41012 | 101.2 | -4.058 | -0.9351 | -2.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8088 | 0.07461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.177 | 1.496 | 1.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.948 | 1.365 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.41012</span> | 101.2 | 0.01728 | 0.2819 | 0.09144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01717 | 0.4972 | 0.8088 | 0.07461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6570 | 2.177 | 1.496 | 1.396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.948 | 1.365 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 17.88 | -0.8521 | 0.09625 | -0.2834 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.006 | 0.008928 | -8.320 | -8.272 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6841 | -8.896 | -4.958 | -5.482 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.690 | -4.565 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 51</span>| 475.17343 | 1.006 | -0.9580 | -0.9344 | -0.9592 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9643 | -0.9219 | -0.6806 | -0.6840 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9328 | -0.5062 | -0.7153 | -0.6852 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5694 | -0.7102 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 475.17343 | 100.6 | -4.058 | -0.9354 | -2.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8127 | 0.07490 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6590 | 2.189 | 1.495 | 1.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.955 | 1.368 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 475.17343</span> | 100.6 | 0.01728 | 0.2818 | 0.09146 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01718 | 0.4972 | 0.8127 | 0.07490 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6590 | 2.189 | 1.495 | 1.397 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.955 | 1.368 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -22.54 | -1.885 | -0.4332 | -0.003109 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9120 | 0.01053 | -7.129 | -7.659 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8338 | -8.700 | -4.918 | -5.365 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.558 | -4.481 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 52</span>| 474.94312 | 1.012 | -0.9570 | -0.9345 | -0.9591 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9638 | -0.9220 | -0.6676 | -0.6825 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9307 | -0.4984 | -0.7146 | -0.6834 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5639 | -0.7072 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.94312 | 101.2 | -4.057 | -0.9355 | -2.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.064 | -0.01101 | 0.8175 | 0.07495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6604 | 2.202 | 1.496 | 1.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.963 | 1.372 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.94312</span> | 101.2 | 0.01730 | 0.2818 | 0.09147 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01718 | 0.4972 | 0.8175 | 0.07495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6604 | 2.202 | 1.496 | 1.399 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.963 | 1.372 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 20.08 | -0.5236 | 0.1181 | -0.2986 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9599 | 0.008866 | -5.310 | -6.088 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8565 | -8.707 | -4.867 | -5.430 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.458 | -4.464 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 53</span>| 474.70657 | 1.007 | -0.9569 | -0.9346 | -0.9588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9629 | -0.9220 | -0.6640 | -0.6851 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9296 | -0.4868 | -0.7112 | -0.6784 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5553 | -0.7021 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.70657 | 100.7 | -4.057 | -0.9356 | -2.392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8188 | 0.07487 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6612 | 2.220 | 1.500 | 1.405 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.976 | 1.378 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.70657</span> | 100.7 | 0.01730 | 0.2818 | 0.09149 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01720 | 0.4972 | 0.8188 | 0.07487 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6612 | 2.220 | 1.500 | 1.405 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.976 | 1.378 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -17.64 | -1.502 | -0.3627 | -0.03824 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.7798 | 0.01049 | -5.965 | -8.154 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5631 | -8.385 | -4.675 | -5.151 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.306 | -4.317 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 54</span>| 474.46623 | 1.012 | -0.9580 | -0.9346 | -0.9586 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9630 | -0.9221 | -0.6659 | -0.6813 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9264 | -0.4751 | -0.7083 | -0.6739 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5464 | -0.6970 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.46623 | 101.2 | -4.058 | -0.9356 | -2.391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8181 | 0.07499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6633 | 2.239 | 1.504 | 1.410 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.989 | 1.384 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.46623</span> | 101.2 | 0.01728 | 0.2818 | 0.09151 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01720 | 0.4972 | 0.8181 | 0.07499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6633 | 2.239 | 1.504 | 1.410 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 1.989 | 1.384 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.93 | -0.7754 | 0.09266 | -0.2754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8835 | 0.009135 | -6.026 | -6.068 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.8217 | -8.210 | -4.532 | -5.141 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -7.011 | -4.237 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 55</span>| 474.23394 | 1.006 | -0.9577 | -0.9351 | -0.9581 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9633 | -0.9221 | -0.6610 | -0.6793 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9234 | -0.4633 | -0.7068 | -0.6694 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5382 | -0.6917 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 474.23394 | 100.6 | -4.058 | -0.9360 | -2.391 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01101 | 0.8199 | 0.07506 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.257 | 1.506 | 1.415 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.001 | 1.390 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 474.23394</span> | 100.6 | 0.01729 | 0.2817 | 0.09156 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01719 | 0.4972 | 0.8199 | 0.07506 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.257 | 1.506 | 1.415 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.001 | 1.390 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.30 | -1.703 | -0.3919 | -0.002629 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8653 | 0.01064 | -4.947 | -7.765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7818 | -8.010 | -4.437 | -4.875 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -6.938 | -4.094 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 56</span>| 473.98878 | 1.011 | -0.9542 | -0.9354 | -0.9578 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9619 | -0.9222 | -0.6621 | -0.6770 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9235 | -0.4507 | -0.7053 | -0.6648 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5298 | -0.6863 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.98878 | 101.1 | -4.054 | -0.9363 | -2.390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.062 | -0.01101 | 0.8195 | 0.07514 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6653 | 2.277 | 1.508 | 1.421 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.013 | 1.396 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.98878</span> | 101.1 | 0.01735 | 0.2816 | 0.09159 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01722 | 0.4972 | 0.8195 | 0.07514 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6653 | 2.277 | 1.508 | 1.421 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.013 | 1.396 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 57</span>| 473.76836 | 1.011 | -0.9500 | -0.9359 | -0.9574 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9601 | -0.9223 | -0.6653 | -0.6763 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9234 | -0.4357 | -0.7046 | -0.6601 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5205 | -0.6802 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 473.76836 | 101.1 | -4.050 | -0.9368 | -2.390 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.060 | -0.01101 | 0.8183 | 0.07516 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.301 | 1.509 | 1.426 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.027 | 1.403 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 473.76836</span> | 101.1 | 0.01742 | 0.2815 | 0.09163 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01725 | 0.4972 | 0.8183 | 0.07516 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6654 | 2.301 | 1.509 | 1.426 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.027 | 1.403 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 58</span>| 472.96708 | 1.009 | -0.9317 | -0.9384 | -0.9555 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9527 | -0.9228 | -0.6791 | -0.6735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9230 | -0.3711 | -0.7015 | -0.6396 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4802 | -0.6537 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.96708 | 100.9 | -4.032 | -0.9391 | -2.388 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.053 | -0.01101 | 0.8133 | 0.07525 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6656 | 2.403 | 1.513 | 1.450 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.087 | 1.433 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.96708</span> | 100.9 | 0.01774 | 0.2811 | 0.09180 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01737 | 0.4972 | 0.8133 | 0.07525 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6656 | 2.403 | 1.513 | 1.450 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.087 | 1.433 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 59</span>| 472.23802 | 1.005 | -0.8811 | -0.9451 | -0.9502 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9323 | -0.9240 | -0.7172 | -0.6658 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9220 | -0.1924 | -0.6930 | -0.5829 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3688 | -0.5805 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.23802 | 100.5 | -3.981 | -0.9455 | -2.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.032 | -0.01103 | 0.7994 | 0.07551 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 2.686 | 1.523 | 1.515 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.251 | 1.518 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.23802</span> | 100.5 | 0.01866 | 0.2798 | 0.09228 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01773 | 0.4972 | 0.7994 | 0.07551 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6663 | 2.686 | 1.523 | 1.515 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.251 | 1.518 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -10.41 | 25.09 | -1.964 | 0.8913 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.956 | 0.02208 | -7.724 | -8.360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01123 | -2.619 | -3.185 | -1.886 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -3.376 | -1.727 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 60</span>| 470.34942 | 1.020 | -1.007 | -0.9408 | -0.9496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9429 | -0.9259 | -0.7397 | -0.6282 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9207 | 0.06578 | -0.6693 | -0.4998 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2002 | -0.4722 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 470.34942 | 102.0 | -4.107 | -0.9414 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.043 | -0.01105 | 0.7911 | 0.07677 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.094 | 1.553 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.34942</span> | 102.0 | 0.01646 | 0.2806 | 0.09235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01755 | 0.4972 | 0.7911 | 0.07677 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.094 | 1.553 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 49.94 | -17.10 | 1.872 | -1.413 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.684 | 0.005064 | -7.591 | -5.431 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2085 | -2.165 | -1.196 | -0.1732 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4074 | -0.2957 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 61</span>| 480.76065 | 0.9913 | -0.9789 | -0.9482 | -0.9314 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.207 | -0.9279 | -0.6546 | -0.4866 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9168 | 0.2296 | -0.6593 | -0.5083 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1307 | -0.4332 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 480.76065 | 99.13 | -4.079 | -0.9483 | -2.364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.307 | -0.01107 | 0.8222 | 0.08152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6698 | 3.353 | 1.566 | 1.601 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.603 | 1.687 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 480.76065</span> | 99.13 | 0.01693 | 0.2792 | 0.09404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01347 | 0.4972 | 0.8222 | 0.08152 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6698 | 3.353 | 1.566 | 1.601 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.603 | 1.687 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 62</span>| 472.12595 | 0.9860 | -0.9933 | -0.9428 | -0.9466 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9755 | -0.9261 | -0.7254 | -0.6089 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9204 | 0.08558 | -0.6674 | -0.5007 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1921 | -0.4676 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 472.12595 | 98.60 | -4.093 | -0.9433 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.076 | -0.01105 | 0.7964 | 0.07742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.125 | 1.556 | 1.609 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.512 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 472.12595</span> | 98.60 | 0.01668 | 0.2802 | 0.09262 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01698 | 0.4972 | 0.7964 | 0.07742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.125 | 1.556 | 1.609 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.512 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 63</span>| 470.26696 | 1.005 | -1.002 | -0.9414 | -0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9444 | -0.9259 | -0.7373 | -0.6265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9207 | 0.06646 | -0.6689 | -0.4998 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4721 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 470.26696 | 100.5 | -4.102 | -0.9420 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.044 | -0.01105 | 0.7920 | 0.07683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.095 | 1.554 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 470.26696</span> | 100.5 | 0.01654 | 0.2805 | 0.09239 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01752 | 0.4972 | 0.7920 | 0.07683 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6672 | 3.095 | 1.554 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -57.97 | -21.53 | 0.3336 | -0.1964 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 4.949 | 0.01388 | -7.299 | -5.475 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3363 | -1.951 | -1.200 | 0.1716 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4705 | -0.2755 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 64</span>| 469.85165 | 1.014 | -0.9972 | -0.9415 | -0.9489 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9548 | -0.9260 | -0.7307 | -0.6235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9208 | 0.07069 | -0.6682 | -0.5004 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1987 | -0.4712 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.85165 | 101.4 | -4.097 | -0.9421 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01105 | 0.7944 | 0.07693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6671 | 3.101 | 1.555 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.85165</span> | 101.4 | 0.01662 | 0.2805 | 0.09241 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.7944 | 0.07693 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6671 | 3.101 | 1.555 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.302 | -15.01 | 1.055 | -0.6015 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.082 | 0.004567 | -8.090 | -5.650 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2579 | -2.336 | -1.339 | -0.08766 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5208 | -0.3062 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 65</span>| 469.69998 | 1.007 | -0.9853 | -0.9423 | -0.9484 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -0.9260 | -0.7231 | -0.6186 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9204 | 0.07309 | -0.6671 | -0.5006 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1982 | -0.4709 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.69998 | 100.7 | -4.085 | -0.9429 | -2.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.7972 | 0.07709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.105 | 1.556 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.69998</span> | 100.7 | 0.01682 | 0.2803 | 0.09245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.7972 | 0.07709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6674 | 3.105 | 1.556 | 1.610 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -36.86 | -12.39 | 0.1028 | 0.1354 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7614 | 0.008951 | -8.542 | -6.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2246 | -2.313 | -1.235 | 0.1010 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5654 | -0.2998 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 66</span>| 469.45579 | 1.013 | -0.9821 | -0.9425 | -0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9260 | -0.7099 | -0.6134 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9182 | 0.07758 | -0.6674 | -0.5042 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1996 | -0.4719 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.45579 | 101.3 | -4.082 | -0.9430 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.8020 | 0.07727 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6689 | 3.112 | 1.556 | 1.605 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.45579</span> | 101.3 | 0.01687 | 0.2803 | 0.09239 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8020 | 0.07727 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6689 | 3.112 | 1.556 | 1.605 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.383 | -7.976 | 0.5709 | -0.2773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.4749 | 0.005686 | -7.013 | -4.742 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3037 | -2.186 | -1.089 | -0.04880 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5661 | -0.3435 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 67</span>| 469.35718 | 1.007 | -0.9760 | -0.9430 | -0.9493 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9561 | -0.9261 | -0.6977 | -0.6075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9166 | 0.08278 | -0.6675 | -0.5068 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4722 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.35718 | 100.7 | -4.076 | -0.9435 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01105 | 0.8065 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6700 | 3.121 | 1.556 | 1.602 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.35718</span> | 100.7 | 0.01698 | 0.2802 | 0.09237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8065 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6700 | 3.121 | 1.556 | 1.602 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -28.34 | -7.406 | -0.07810 | 0.1748 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6873 | 0.009156 | -6.696 | -4.901 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2913 | -2.170 | -1.086 | -0.02443 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6503 | -0.3607 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 68</span>| 469.19639 | 1.012 | -0.9749 | -0.9431 | -0.9497 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9262 | -0.6862 | -0.6021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9137 | 0.09137 | -0.6688 | -0.5111 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2009 | -0.4726 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.19639 | 101.2 | -4.075 | -0.9436 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01105 | 0.8107 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6719 | 3.134 | 1.554 | 1.597 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.19639</span> | 101.2 | 0.01699 | 0.2802 | 0.09233 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8107 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6719 | 3.134 | 1.554 | 1.597 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.760 | -4.629 | 0.3091 | -0.1325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04401 | 0.005819 | -5.826 | -2.903 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1562 | -2.130 | -1.121 | -0.2535 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6922 | -0.4141 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 69</span>| 469.12263 | 1.008 | -0.9713 | -0.9434 | -0.9499 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9262 | -0.6727 | -0.6012 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9123 | 0.09974 | -0.6678 | -0.5134 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2010 | -0.4726 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.12263 | 100.8 | -4.071 | -0.9438 | -2.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01105 | 0.8156 | 0.07768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6728 | 3.147 | 1.555 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.12263</span> | 100.8 | 0.01706 | 0.2801 | 0.09232 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8156 | 0.07768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6728 | 3.147 | 1.555 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.86 | -4.532 | -0.1251 | 0.1663 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1284 | 0.008177 | -5.101 | -3.487 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2183 | -2.137 | -1.171 | -0.2991 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6817 | -0.4261 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 70</span>| 469.02483 | 1.011 | -0.9711 | -0.9434 | -0.9500 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9263 | -0.6616 | -0.6038 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9105 | 0.1111 | -0.6656 | -0.5157 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2026 | -0.4730 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 469.02483 | 101.1 | -4.071 | -0.9439 | -2.383 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01105 | 0.8196 | 0.07759 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6741 | 3.165 | 1.558 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.641 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 469.02483</span> | 101.1 | 0.01706 | 0.2801 | 0.09230 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8196 | 0.07759 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6741 | 3.165 | 1.558 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.641 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.786 | -2.589 | 0.2046 | -0.1061 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1383 | 0.006373 | -4.080 | -2.588 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1418 | -1.956 | -0.9118 | -0.4226 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7530 | -0.4429 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 71</span>| 468.97618 | 1.009 | -0.9710 | -0.9439 | -0.9494 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9625 | -0.9265 | -0.6573 | -0.5998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9085 | 0.1255 | -0.6648 | -0.5157 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2015 | -0.4719 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.97618 | 100.9 | -4.071 | -0.9443 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.063 | -0.01106 | 0.8212 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6755 | 3.188 | 1.559 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.97618</span> | 100.9 | 0.01706 | 0.2800 | 0.09236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01721 | 0.4972 | 0.8212 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6755 | 3.188 | 1.559 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -11.25 | -3.431 | -0.02518 | 0.1501 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -1.529 | 0.005347 | -4.655 | -3.448 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3102 | -2.013 | -0.8937 | -0.3742 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7403 | -0.4511 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 72</span>| 468.91299 | 1.010 | -0.9702 | -0.9444 | -0.9496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9534 | -0.9266 | -0.6524 | -0.5929 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9051 | 0.1362 | -0.6665 | -0.5172 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2029 | -0.4725 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.91299 | 101.0 | -4.070 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.053 | -0.01106 | 0.8230 | 0.07796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6777 | 3.205 | 1.557 | 1.590 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.496 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.91299</span> | 101.0 | 0.01707 | 0.2799 | 0.09234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01736 | 0.4972 | 0.8230 | 0.07796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6777 | 3.205 | 1.557 | 1.590 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.496 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -8.129 | -2.859 | -0.02802 | -0.004107 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 1.281 | 0.009120 | -4.291 | -2.058 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1551 | -2.052 | -1.121 | -0.5699 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7547 | -0.4743 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 73</span>| 471.25018 | 1.036 | -0.9607 | -0.9443 | -0.9496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9266 | -0.6382 | -0.5860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9046 | 0.1430 | -0.6628 | -0.5153 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2004 | -0.4709 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 471.25018 | 103.6 | -4.061 | -0.9447 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01106 | 0.8282 | 0.07819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6781 | 3.216 | 1.562 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 471.25018</span> | 103.6 | 0.01724 | 0.2800 | 0.09234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8282 | 0.07819 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6781 | 3.216 | 1.562 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 74</span>| 468.90555 | 1.012 | -0.9692 | -0.9444 | -0.9496 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9538 | -0.9266 | -0.6510 | -0.5922 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9050 | 0.1369 | -0.6661 | -0.5170 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2027 | -0.4723 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.90555 | 101.2 | -4.069 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.054 | -0.01106 | 0.8235 | 0.07798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6778 | 3.206 | 1.557 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.90555</span> | 101.2 | 0.01709 | 0.2799 | 0.09234 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01736 | 0.4972 | 0.8235 | 0.07798 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6778 | 3.206 | 1.557 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 11.48 | -1.027 | 0.1960 | -0.1655 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9827 | 0.007474 | -3.960 | -2.226 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2199 | -2.046 | -1.158 | -0.6171 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7493 | -0.4797 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 75</span>| 468.88608 | 1.010 | -0.9691 | -0.9444 | -0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9542 | -0.9266 | -0.6497 | -0.5917 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9044 | 0.1391 | -0.6659 | -0.5166 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2026 | -0.4722 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.88608 | 101.0 | -4.069 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.054 | -0.01106 | 0.8240 | 0.07799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6782 | 3.210 | 1.558 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.88608</span> | 101.0 | 0.01709 | 0.2799 | 0.09235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01735 | 0.4972 | 0.8240 | 0.07799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6782 | 3.210 | 1.558 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.497 | 1.642 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.784 | -1.944 | 0.009889 | -0.02065 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.9781 | 0.008521 | -3.685 | -1.489 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08345 | -1.963 | -0.9408 | -0.4978 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7271 | -0.4658 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 76</span>| 468.87604 | 1.012 | -0.9680 | -0.9444 | -0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9547 | -0.9266 | -0.6476 | -0.5909 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9043 | 0.1402 | -0.6654 | -0.5163 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2021 | -0.4719 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.87604 | 101.2 | -4.068 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8248 | 0.07802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6783 | 3.211 | 1.558 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.87604</span> | 101.2 | 0.01711 | 0.2799 | 0.09235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8248 | 0.07802 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6783 | 3.211 | 1.558 | 1.591 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.309 | -0.5261 | 0.1314 | -0.1053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 0.007435 | -3.809 | -2.129 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2297 | -2.013 | -1.108 | -0.5855 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7533 | -0.4780 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 77</span>| 468.85962 | 1.010 | -0.9680 | -0.9444 | -0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9550 | -0.9266 | -0.6462 | -0.5907 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9037 | 0.1428 | -0.6653 | -0.5160 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2020 | -0.4717 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.85962 | 101.0 | -4.068 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8253 | 0.07803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6787 | 3.215 | 1.558 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.85962</span> | 101.0 | 0.01711 | 0.2799 | 0.09235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8253 | 0.07803 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6787 | 3.215 | 1.558 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.556 | -1.258 | -0.007590 | 0.001179 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7035 | 0.008243 | -4.446 | -2.277 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2406 | -1.984 | -1.075 | -0.5476 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7588 | -0.4741 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 78</span>| 468.84535 | 1.011 | -0.9673 | -0.9444 | -0.9495 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9554 | -0.9266 | -0.6436 | -0.5895 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9036 | 0.1439 | -0.6647 | -0.5157 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2016 | -0.4714 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.84535 | 101.1 | -4.067 | -0.9448 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8262 | 0.07807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6788 | 3.217 | 1.559 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.84535</span> | 101.1 | 0.01712 | 0.2799 | 0.09235 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8262 | 0.07807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6788 | 3.217 | 1.559 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.498 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.130 | -0.4165 | 0.05789 | -0.04298 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5152 | 0.007618 | -4.342 | -2.024 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2412 | -1.936 | -0.8986 | -0.4874 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7551 | -0.4761 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 79</span>| 468.83559 | 1.009 | -0.9672 | -0.9445 | -0.9494 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9556 | -0.9266 | -0.6414 | -0.5890 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9032 | 0.1455 | -0.6647 | -0.5153 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2012 | -0.4711 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.83559 | 100.9 | -4.067 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8270 | 0.07809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6790 | 3.220 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.83559</span> | 100.9 | 0.01713 | 0.2799 | 0.09236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8270 | 0.07809 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6790 | 3.220 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.643 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.676 | -1.212 | -0.1115 | 0.08612 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.5488 | 0.008589 | -2.761 | -2.165 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2456 | -1.924 | -0.8622 | -0.4413 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7592 | -0.4720 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 80</span>| 468.82320 | 1.011 | -0.9670 | -0.9445 | -0.9494 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9559 | -0.9267 | -0.6401 | -0.5885 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9025 | 0.1478 | -0.6651 | -0.5152 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2008 | -0.4708 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.8232 | 101.1 | -4.067 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8275 | 0.07810 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6795 | 3.223 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.8232</span> | 101.1 | 0.01713 | 0.2799 | 0.09236 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8275 | 0.07810 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6795 | 3.223 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.499 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.440 | -0.1810 | 0.05193 | -0.03082 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3483 | 0.007438 | -3.541 | -1.923 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2409 | -1.947 | -1.058 | -0.5469 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7518 | -0.4735 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 81</span>| 468.81154 | 1.010 | -0.9671 | -0.9445 | -0.9493 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9267 | -0.6389 | -0.5880 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9017 | 0.1505 | -0.6652 | -0.5150 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2005 | -0.4704 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.81154 | 101.0 | -4.067 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8279 | 0.07812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6800 | 3.228 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.81154</span> | 101.0 | 0.01713 | 0.2799 | 0.09237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8279 | 0.07812 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6800 | 3.228 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.500 | 1.644 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.875 | -0.7736 | -0.05343 | 0.05244 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.3113 | 0.007978 | -4.161 | -2.012 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2433 | -1.896 | -0.8853 | -0.4539 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7524 | -0.4694 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 82</span>| 468.80001 | 1.011 | -0.9668 | -0.9445 | -0.9493 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9563 | -0.9267 | -0.6364 | -0.5873 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9013 | 0.1522 | -0.6651 | -0.5147 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2001 | -0.4701 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.80001 | 101.1 | -4.067 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8288 | 0.07814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6803 | 3.230 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.80001</span> | 101.1 | 0.01713 | 0.2799 | 0.09237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8288 | 0.07814 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6803 | 3.230 | 1.559 | 1.593 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 6.046 | 0.03721 | 0.05257 | -0.02595 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1943 | 0.007238 | -2.985 | -2.233 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3122 | -1.891 | -0.9609 | -0.5652 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.8019 | -0.4712 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 83</span>| 468.79133 | 1.009 | -0.9669 | -0.9445 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9565 | -0.9267 | -0.6348 | -0.5869 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9006 | 0.1543 | -0.6654 | -0.5144 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1996 | -0.4698 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.79133 | 100.9 | -4.067 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8294 | 0.07816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6807 | 3.234 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.79133</span> | 100.9 | 0.01713 | 0.2799 | 0.09237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8294 | 0.07816 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6807 | 3.234 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.501 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.226 | -0.9038 | -0.1166 | 0.1039 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2475 | 0.008246 | -3.388 | -1.948 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2420 | -1.872 | -0.8620 | -0.4291 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7186 | -0.4561 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 84</span>| 468.77848 | 1.011 | -0.9668 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9568 | -0.9267 | -0.6338 | -0.5863 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8997 | 0.1569 | -0.6658 | -0.5142 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1992 | -0.4695 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.77848 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8298 | 0.07818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6814 | 3.238 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.502 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.77848</span> | 101.1 | 0.01713 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8298 | 0.07818 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6814 | 3.238 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.502 | 1.645 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.503 | -0.1762 | 0.005994 | 0.01651 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.06327 | 0.007339 | -4.407 | -2.185 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3133 | -1.836 | -0.8110 | -0.4803 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7946 | -0.4665 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 85</span>| 468.76805 | 1.010 | -0.9668 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9267 | -0.6312 | -0.5853 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8993 | 0.1583 | -0.6657 | -0.5139 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1987 | -0.4691 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.76805 | 101.0 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8307 | 0.07821 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6816 | 3.240 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.76805</span> | 101.0 | 0.01713 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8307 | 0.07821 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6816 | 3.240 | 1.558 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.980 | -0.7098 | -0.1045 | 0.1001 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.1097 | 0.008007 | -2.998 | -1.799 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2421 | -1.902 | -1.021 | -0.4929 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7234 | -0.4545 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 86</span>| 468.76178 | 1.012 | -0.9666 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9268 | -0.6296 | -0.5849 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8987 | 0.1602 | -0.6657 | -0.5136 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1982 | -0.4689 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.76178 | 101.2 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8313 | 0.07822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6820 | 3.243 | 1.558 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.76178</span> | 101.2 | 0.01714 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8313 | 0.07822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6820 | 3.243 | 1.558 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.503 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 9.381 | 0.4945 | 0.08709 | -0.04347 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04178 | 0.006758 | -3.785 | -1.947 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3007 | -1.819 | -0.8940 | -0.4901 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7836 | -0.4662 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 87</span>| 468.74724 | 1.010 | -0.9668 | -0.9447 | -0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6284 | -0.5849 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8978 | 0.1628 | -0.6658 | -0.5134 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1979 | -0.4686 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.74724 | 101.0 | -4.067 | -0.9451 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8318 | 0.07822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6827 | 3.247 | 1.558 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.74724</span> | 101.0 | 0.01713 | 0.2799 | 0.09239 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8318 | 0.07822 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6827 | 3.247 | 1.558 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.646 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.251 | -0.3146 | -0.04610 | 0.05724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.02086 | 0.007590 | -4.230 | -2.098 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3136 | -1.833 | -0.9365 | -0.5244 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7857 | -0.4618 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 88</span>| 468.73570 | 1.011 | -0.9666 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6257 | -0.5836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8976 | 0.1639 | -0.6652 | -0.5131 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1974 | -0.4683 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.7357 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8327 | 0.07827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6828 | 3.249 | 1.559 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.7357</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8327 | 0.07827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6828 | 3.249 | 1.559 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.504 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 4.473 | 0.2106 | 0.02342 | 0.003517 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03354 | 0.007130 | -3.431 | -1.904 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3114 | -1.829 | -0.9161 | -0.5352 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7806 | -0.4641 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 89</span>| 468.73562 | 1.009 | -0.9667 | -0.9447 | -0.9491 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6239 | -0.5826 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8973 | 0.1651 | -0.6648 | -0.5128 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1970 | -0.4681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.73562 | 100.9 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8334 | 0.07830 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.73562</span> | 100.9 | 0.01713 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8334 | 0.07830 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | C| Central Diff. | -12.26 | -1.176 | -0.2138 | 0.1217 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02157 | 0.008077 | -2.776 | -1.301 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1367 | -1.738 | -0.7465 | -0.4531 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7359 | -0.4611 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 90</span>| 468.72331 | 1.010 | -0.9665 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6235 | -0.5825 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8973 | 0.1654 | -0.6647 | -0.5127 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1969 | -0.4680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.72331 | 101.0 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8335 | 0.07831 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.72331</span> | 101.0 | 0.01714 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8335 | 0.07831 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6830 | 3.251 | 1.559 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.505 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3583 | -0.08989 | -0.03828 | 0.04946 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.006154 | 0.007526 | -3.405 | -1.898 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3214 | -1.836 | -0.8751 | -0.5118 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7778 | -0.4622 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 91</span>| 468.71715 | 1.011 | -0.9665 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6223 | -0.5817 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8972 | 0.1661 | -0.6643 | -0.5125 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1966 | -0.4678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.71715 | 101.1 | -4.067 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8340 | 0.07833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6831 | 3.252 | 1.560 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.71715</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8340 | 0.07833 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6831 | 3.252 | 1.560 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.647 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 92</span>| 468.70862 | 1.011 | -0.9665 | -0.9446 | -0.9492 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6204 | -0.5807 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8970 | 0.1671 | -0.6639 | -0.5123 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1962 | -0.4676 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.70862 | 101.1 | -4.066 | -0.9450 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8347 | 0.07836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6832 | 3.254 | 1.560 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.70862</span> | 101.1 | 0.01714 | 0.2799 | 0.09238 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8347 | 0.07836 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6832 | 3.254 | 1.560 | 1.596 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.506 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 93</span>| 468.69301 | 1.011 | -0.9664 | -0.9446 | -0.9493 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9268 | -0.6166 | -0.5786 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8967 | 0.1691 | -0.6629 | -0.5117 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1953 | -0.4671 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.69301 | 101.1 | -4.066 | -0.9449 | -2.382 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01106 | 0.8361 | 0.07843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6834 | 3.257 | 1.562 | 1.597 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.508 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.69301</span> | 101.1 | 0.01714 | 0.2799 | 0.09237 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8361 | 0.07843 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6834 | 3.257 | 1.562 | 1.597 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.508 | 1.648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.000 | 0.4463 | 0.03173 | -0.005614 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04729 | 0.007073 | -3.041 | -1.513 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3269 | -1.766 | -0.6347 | -0.4208 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.7611 | -0.4631 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 94</span>| 468.66018 | 1.011 | -0.9666 | -0.9442 | -0.9484 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9562 | -0.9269 | -0.6101 | -0.5828 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8947 | 0.1828 | -0.6704 | -0.5138 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1918 | -0.4639 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.66018 | 101.1 | -4.067 | -0.9446 | -2.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01106 | 0.8385 | 0.07829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6847 | 3.279 | 1.552 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.513 | 1.652 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.66018</span> | 101.1 | 0.01714 | 0.2800 | 0.09245 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8385 | 0.07829 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6847 | 3.279 | 1.552 | 1.594 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.513 | 1.652 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 95</span>| 468.61872 | 1.011 | -0.9669 | -0.9434 | -0.9467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9547 | -0.9271 | -0.5984 | -0.5914 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8911 | 0.2086 | -0.6849 | -0.5181 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1852 | -0.4581 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.61872 | 101.1 | -4.067 | -0.9439 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.055 | -0.01106 | 0.8427 | 0.07801 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6872 | 3.320 | 1.534 | 1.589 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.523 | 1.658 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.61872</span> | 101.1 | 0.01713 | 0.2801 | 0.09261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01734 | 0.4972 | 0.8427 | 0.07801 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6872 | 3.320 | 1.534 | 1.589 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.523 | 1.658 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.484 | 0.5384 | 0.08463 | 0.09865 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7055 | 0.007848 | -2.909 | -1.559 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2162 | -1.642 | -1.728 | -0.7121 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5947 | -0.3648 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 96</span>| 468.58548 | 1.008 | -0.9690 | -0.9515 | -0.9524 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9418 | -0.9281 | -0.5713 | -0.6320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8823 | 0.2961 | -0.6589 | -0.5284 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1884 | -0.4503 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.58548 | 100.8 | -4.069 | -0.9515 | -2.385 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.042 | -0.01107 | 0.8526 | 0.07665 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6931 | 3.458 | 1.567 | 1.578 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.518 | 1.667 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.58548</span> | 100.8 | 0.01709 | 0.2786 | 0.09208 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01757 | 0.4972 | 0.8526 | 0.07665 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6931 | 3.458 | 1.567 | 1.578 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.518 | 1.667 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -20.63 | -1.258 | -0.4941 | -0.2790 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 5.133 | 0.01399 | -2.360 | -3.936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.04374 | -1.146 | -0.2901 | -1.004 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6864 | -0.2503 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 97</span>| 468.42330 | 1.011 | -0.9777 | -0.9596 | -0.9476 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9583 | -0.9295 | -0.5827 | -0.6211 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8760 | 0.3979 | -0.6632 | -0.5247 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1834 | -0.4404 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.4233 | 101.1 | -4.078 | -0.9591 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8485 | 0.07701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6974 | 3.619 | 1.561 | 1.582 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.525 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.4233</span> | 101.1 | 0.01695 | 0.2771 | 0.09253 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8485 | 0.07701 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6974 | 3.619 | 1.561 | 1.582 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.525 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.203 | -3.445 | -0.3661 | -0.1876 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3413 | 0.004713 | -2.617 | -2.520 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09908 | -0.8887 | -0.1336 | -0.9981 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6593 | -0.1712 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 98</span>| 468.44544 | 1.015 | -0.9711 | -0.9083 | -0.9392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9571 | -0.9308 | -0.5728 | -0.6140 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9111 | 0.4459 | -0.6774 | -0.4582 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1728 | -0.4486 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.44544 | 101.5 | -4.071 | -0.9109 | -2.372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01110 | 0.8520 | 0.07725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6737 | 3.695 | 1.543 | 1.658 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.541 | 1.669 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.44544</span> | 101.5 | 0.01706 | 0.2868 | 0.09331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8520 | 0.07725 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6737 | 3.695 | 1.543 | 1.658 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.541 | 1.669 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 99</span>| 468.45245 | 1.016 | -0.9696 | -0.9377 | -0.9438 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9300 | -0.5745 | -0.6143 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8908 | 0.4193 | -0.6689 | -0.4955 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1780 | -0.4435 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.45245 | 101.6 | -4.070 | -0.9385 | -2.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01109 | 0.8514 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6874 | 3.653 | 1.554 | 1.615 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.533 | 1.675 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.45245</span> | 101.6 | 0.01708 | 0.2812 | 0.09288 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8514 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6874 | 3.653 | 1.554 | 1.615 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.533 | 1.675 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 100</span>| 468.50368 | 1.017 | -0.9688 | -0.9537 | -0.9463 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9296 | -0.5755 | -0.6144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8797 | 0.4047 | -0.6643 | -0.5158 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1808 | -0.4408 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.50368 | 101.7 | -4.069 | -0.9536 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01109 | 0.8511 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6949 | 3.630 | 1.560 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.529 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.50368</span> | 101.7 | 0.01710 | 0.2782 | 0.09265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8511 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6949 | 3.630 | 1.560 | 1.592 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.529 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 101</span>| 468.41664 | 1.014 | -0.9744 | -0.9593 | -0.9474 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9295 | -0.5802 | -0.6187 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8761 | 0.3987 | -0.6631 | -0.5237 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1828 | -0.4402 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.41664 | 101.4 | -4.074 | -0.9588 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8494 | 0.07709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6973 | 3.620 | 1.561 | 1.583 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.526 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.41664</span> | 101.4 | 0.01700 | 0.2771 | 0.09254 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8494 | 0.07709 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6973 | 3.620 | 1.561 | 1.583 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.526 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 15.72 | -0.02243 | -0.2559 | -0.2642 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4515 | 0.003975 | -3.178 | -2.839 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02889 | -0.8526 | -0.3239 | -1.069 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6251 | -0.1666 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 102</span>| 468.39161 | 1.011 | -0.9744 | -0.9571 | -0.9468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9295 | -0.5795 | -0.6181 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8777 | 0.4014 | -0.6637 | -0.5208 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1824 | -0.4404 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.39161 | 101.1 | -4.074 | -0.9567 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8496 | 0.07711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6962 | 3.624 | 1.561 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.527 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.39161</span> | 101.1 | 0.01700 | 0.2775 | 0.09260 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8496 | 0.07711 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6962 | 3.624 | 1.561 | 1.586 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.527 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.3129 | -1.347 | -0.3359 | -0.08922 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3284 | 0.005471 | -2.643 | -3.028 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08821 | -0.8778 | -0.3083 | -0.9349 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6501 | -0.1781 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 103</span>| 468.37315 | 1.012 | -0.9728 | -0.9567 | -0.9467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9295 | -0.5763 | -0.6144 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8776 | 0.4024 | -0.6633 | -0.5197 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1816 | -0.4402 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.37315 | 101.2 | -4.073 | -0.9564 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8508 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6963 | 3.626 | 1.561 | 1.588 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.528 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.37315</span> | 101.2 | 0.01703 | 0.2776 | 0.09261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8508 | 0.07724 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6963 | 3.626 | 1.561 | 1.588 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.528 | 1.679 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.643 | -0.05906 | -0.3284 | -0.08464 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2659 | 0.005628 | -2.441 | -2.741 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1033 | -0.8597 | -0.2783 | -0.9091 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.6423 | -0.1835 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 104</span>| 468.35774 | 1.011 | -0.9727 | -0.9524 | -0.9471 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9297 | -0.5762 | -0.6128 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8791 | 0.4096 | -0.6644 | -0.5136 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1797 | -0.4410 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.35774 | 101.1 | -4.073 | -0.9523 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8508 | 0.07729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6953 | 3.637 | 1.560 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.531 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.35774</span> | 101.1 | 0.01703 | 0.2784 | 0.09257 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8508 | 0.07729 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6953 | 3.637 | 1.560 | 1.595 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.531 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -4.235 | -0.7549 | -0.2072 | -0.03117 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2512 | 0.006470 | -2.488 | -2.805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1485 | -0.7903 | -0.1532 | -0.6368 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5813 | -0.1871 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 105</span>| 468.34230 | 1.012 | -0.9728 | -0.9537 | -0.9473 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9300 | -0.5748 | -0.6111 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8817 | 0.4177 | -0.6661 | -0.5086 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1765 | -0.4413 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.3423 | 101.2 | -4.073 | -0.9535 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01109 | 0.8513 | 0.07735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6935 | 3.650 | 1.558 | 1.600 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.535 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.3423</span> | 101.2 | 0.01703 | 0.2782 | 0.09256 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8513 | 0.07735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6935 | 3.650 | 1.558 | 1.600 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.535 | 1.678 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 5.528 | 0.1613 | -0.1518 | -0.1427 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4211 | 0.005662 | -2.339 | -2.549 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1833 | -0.8387 | -0.3838 | -0.5791 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5586 | -0.2081 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 106</span>| 468.32828 | 1.011 | -0.9730 | -0.9582 | -0.9446 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9303 | -0.5739 | -0.6081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8827 | 0.4247 | -0.6653 | -0.5110 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1721 | -0.4394 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.32828 | 101.1 | -4.073 | -0.9578 | -2.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01110 | 0.8517 | 0.07745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6929 | 3.661 | 1.559 | 1.598 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.542 | 1.680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.32828</span> | 101.1 | 0.01703 | 0.2773 | 0.09281 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8517 | 0.07745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6929 | 3.661 | 1.559 | 1.598 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.542 | 1.680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.625 | -0.2716 | -0.4478 | 0.07059 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3746 | 0.006164 | -2.097 | -1.611 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.05708 | -0.8042 | -0.2658 | -0.6338 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.5023 | -0.1867 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 107</span>| 468.31633 | 1.012 | -0.9727 | -0.9524 | -0.9447 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9305 | -0.5707 | -0.6067 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8839 | 0.4327 | -0.6650 | -0.5105 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1703 | -0.4382 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.31633 | 101.2 | -4.073 | -0.9523 | -2.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01110 | 0.8528 | 0.07749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6921 | 3.674 | 1.559 | 1.598 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.545 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.31633</span> | 101.2 | 0.01703 | 0.2784 | 0.09280 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8528 | 0.07749 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6921 | 3.674 | 1.559 | 1.598 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.545 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 8.853 | 0.6395 | -0.04718 | -0.01095 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5142 | 0.005281 | -1.984 | -1.469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.06825 | -0.7616 | -0.1275 | -0.5767 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4529 | -0.1729 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 108</span>| 468.30195 | 1.011 | -0.9730 | -0.9497 | -0.9482 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9586 | -0.9308 | -0.5675 | -0.6075 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8868 | 0.4402 | -0.6670 | -0.5066 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1704 | -0.4381 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.30195 | 101.1 | -4.073 | -0.9498 | -2.381 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.059 | -0.01110 | 0.8540 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6901 | 3.686 | 1.556 | 1.603 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.544 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.30195</span> | 101.1 | 0.01703 | 0.2789 | 0.09247 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01727 | 0.4972 | 0.8540 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6901 | 3.686 | 1.556 | 1.603 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.544 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.407 | -0.4624 | -0.02880 | -0.1214 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5499 | 0.005628 | -1.325 | -1.518 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1161 | -0.7707 | -0.3300 | -0.4912 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4772 | -0.1931 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 109</span>| 468.29210 | 1.012 | -0.9733 | -0.9523 | -0.9459 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9311 | -0.5658 | -0.6073 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8878 | 0.4488 | -0.6682 | -0.5015 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1697 | -0.4385 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.2921 | 101.2 | -4.073 | -0.9523 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01111 | 0.8546 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6894 | 3.699 | 1.555 | 1.608 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.2921</span> | 101.2 | 0.01702 | 0.2784 | 0.09269 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8546 | 0.07747 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6894 | 3.699 | 1.555 | 1.608 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.681 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 110</span>| 468.28540 | 1.012 | -0.9739 | -0.9554 | -0.9432 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9314 | -0.5648 | -0.6081 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8889 | 0.4579 | -0.6697 | -0.4962 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1692 | -0.4390 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.2854 | 101.2 | -4.074 | -0.9551 | -2.376 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01111 | 0.8550 | 0.07745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6886 | 3.714 | 1.553 | 1.615 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.2854</span> | 101.2 | 0.01701 | 0.2779 | 0.09293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8550 | 0.07745 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6886 | 3.714 | 1.553 | 1.615 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.546 | 1.680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 3.644 | 0.03668 | -0.1986 | 0.05251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5265 | 0.006364 | -2.013 | -2.999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3077 | -0.7577 | -0.4283 | -0.2217 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.4457 | -0.1968 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 111</span>| 468.26285 | 1.012 | -0.9738 | -0.9546 | -0.9455 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9321 | -0.5638 | -0.6053 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8894 | 0.4796 | -0.6701 | -0.4937 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1665 | -0.4375 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.26285 | 101.2 | -4.074 | -0.9544 | -2.378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01112 | 0.8554 | 0.07754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.748 | 1.552 | 1.617 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.550 | 1.682 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26285</span> | 101.2 | 0.01701 | 0.2780 | 0.09272 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8554 | 0.07754 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.748 | 1.552 | 1.617 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.550 | 1.682 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 112</span>| 468.24808 | 1.012 | -0.9737 | -0.9538 | -0.9478 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9581 | -0.9328 | -0.5632 | -0.6032 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8900 | 0.5018 | -0.6707 | -0.4913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1639 | -0.4361 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.24808 | 101.2 | -4.074 | -0.9537 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8556 | 0.07761 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6879 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24808</span> | 101.2 | 0.01701 | 0.2781 | 0.09251 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8556 | 0.07761 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6879 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 7.572 | 0.7442 | -0.1004 | -0.2485 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5511 | 0.005645 | -1.896 | -1.976 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3421 | -0.6164 | -0.3384 | -0.1002 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3637 | -0.1858 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 113</span>| 468.24925 | 1.009 | -0.9744 | -0.9459 | -0.9275 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9342 | -0.5606 | -0.6003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8814 | 0.5390 | -0.6664 | -0.4916 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1575 | -0.4319 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.24925 | 100.9 | -4.074 | -0.9463 | -2.360 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01114 | 0.8565 | 0.07771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6937 | 3.842 | 1.557 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.563 | 1.689 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24925</span> | 100.9 | 0.01700 | 0.2796 | 0.09441 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8565 | 0.07771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6937 | 3.842 | 1.557 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.563 | 1.689 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 114</span>| 468.25666 | 1.009 | -0.9742 | -0.9500 | -0.9379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9335 | -0.5615 | -0.6013 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8858 | 0.5198 | -0.6685 | -0.4914 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1608 | -0.4340 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.25666 | 100.9 | -4.074 | -0.9501 | -2.371 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8562 | 0.07768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6908 | 3.812 | 1.554 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.686 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.25666</span> | 100.9 | 0.01701 | 0.2789 | 0.09342 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07768 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6908 | 3.812 | 1.554 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.686 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 115</span>| 468.26483 | 1.009 | -0.9741 | -0.9524 | -0.9439 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9331 | -0.5620 | -0.6018 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8883 | 0.5089 | -0.6697 | -0.4913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1626 | -0.4352 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.26483 | 100.9 | -4.074 | -0.9523 | -2.377 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8560 | 0.07766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 3.794 | 1.553 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26483</span> | 100.9 | 0.01701 | 0.2784 | 0.09287 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8560 | 0.07766 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6891 | 3.794 | 1.553 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 116</span>| 468.25961 | 1.009 | -0.9740 | -0.9538 | -0.9477 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9328 | -0.5624 | -0.6023 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5020 | -0.6705 | -0.4913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4360 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.25961 | 100.9 | -4.074 | -0.9536 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8558 | 0.07764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.25961</span> | 100.9 | 0.01701 | 0.2782 | 0.09252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8558 | 0.07764 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 117</span>| 468.24351 | 1.011 | -0.9738 | -0.9538 | -0.9477 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9580 | -0.9328 | -0.5629 | -0.6029 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8899 | 0.5019 | -0.6706 | -0.4913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1638 | -0.4360 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.24351 | 101.1 | -4.074 | -0.9537 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8557 | 0.07762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24351</span> | 101.1 | 0.01701 | 0.2781 | 0.09252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8557 | 0.07762 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6880 | 3.783 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -0.7570 | -0.04882 | -0.1901 | -0.1704 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4436 | 0.006358 | -1.944 | -2.069 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3547 | -0.6277 | -0.2411 | -0.07768 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3909 | -0.1932 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 118</span>| 468.24096 | 1.012 | -0.9738 | -0.9538 | -0.9477 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9579 | -0.9328 | -0.5622 | -0.6021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5021 | -0.6705 | -0.4913 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4360 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.24096 | 101.2 | -4.074 | -0.9536 | -2.380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8559 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.784 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.24096</span> | 101.2 | 0.01701 | 0.2782 | 0.09252 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8559 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.784 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.456 | 0.1549 | -0.1619 | -0.1892 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4078 | 0.006267 | -1.860 | -2.735 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3543 | -0.6265 | -0.1851 | -0.08656 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3612 | -0.1856 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 119</span>| 468.23716 | 1.012 | -0.9738 | -0.9536 | -0.9467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9576 | -0.9329 | -0.5614 | -0.6008 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8898 | 0.5037 | -0.6704 | -0.4911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1638 | -0.4357 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23716 | 101.2 | -4.074 | -0.9534 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8562 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23716</span> | 101.2 | 0.01701 | 0.2782 | 0.09261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.250 | 0.2329 | -0.1405 | -0.1467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3393 | 0.006453 | -1.023 | -1.889 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3583 | -0.6239 | -0.2353 | -0.09107 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3636 | -0.1837 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 120</span>| 468.26529 | 1.008 | -0.9742 | -0.9534 | -0.9465 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9571 | -0.9329 | -0.5599 | -0.5980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | 0.5046 | -0.6700 | -0.4910 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1633 | -0.4354 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.26529 | 100.8 | -4.074 | -0.9532 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8568 | 0.07778 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.553 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.26529</span> | 100.8 | 0.01701 | 0.2782 | 0.09263 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8568 | 0.07778 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.553 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 121</span>| 468.23604 | 1.011 | -0.9739 | -0.9535 | -0.9467 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9329 | -0.5612 | -0.6003 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8897 | 0.5039 | -0.6703 | -0.4911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1637 | -0.4357 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23604 | 101.1 | -4.074 | -0.9534 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01113 | 0.8563 | 0.07771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23604</span> | 101.1 | 0.01701 | 0.2782 | 0.09261 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8563 | 0.07771 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6881 | 3.786 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.554 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.188 | -0.1927 | -0.1868 | -0.1045 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2665 | 0.006857 | -1.024 | -1.172 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2153 | -0.6125 | -0.1502 | -0.07921 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3902 | -0.1918 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 122</span>| 468.23464 | 1.012 | -0.9738 | -0.9534 | -0.9465 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9329 | -0.5609 | -0.6000 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8895 | 0.5043 | -0.6702 | -0.4911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1635 | -0.4356 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23464 | 101.2 | -4.074 | -0.9533 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8564 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.787 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23464</span> | 101.2 | 0.01701 | 0.2782 | 0.09263 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8564 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6883 | 3.787 | 1.552 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.857 | 0.1925 | -0.1360 | -0.1332 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2859 | 0.006578 | -0.9819 | -1.076 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2136 | -0.6087 | -0.2154 | -0.09459 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3609 | -0.1836 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 123</span>| 468.23346 | 1.011 | -0.9739 | -0.9532 | -0.9463 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9329 | -0.5607 | -0.5998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8893 | 0.5049 | -0.6701 | -0.4911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1633 | -0.4355 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23346 | 101.1 | -4.074 | -0.9531 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8565 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.552 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23346</span> | 101.1 | 0.01701 | 0.2783 | 0.09265 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8565 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6884 | 3.788 | 1.552 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.684 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.112 | -0.08635 | -0.1600 | -0.09176 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2402 | 0.006873 | -0.9941 | -1.084 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2133 | -0.6080 | -0.2006 | -0.08423 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.3853 | -0.1906 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 124</span>| 468.23209 | 1.012 | -0.9738 | -0.9531 | -0.9461 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9329 | -0.5604 | -0.5995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8891 | 0.5054 | -0.6700 | -0.4910 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1631 | -0.4354 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23209 | 101.2 | -4.074 | -0.9530 | -2.379 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8566 | 0.07774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6885 | 3.789 | 1.553 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23209</span> | 101.2 | 0.01701 | 0.2783 | 0.09266 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8566 | 0.07774 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6885 | 3.789 | 1.553 | 1.621 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.555 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 125</span>| 468.23061 | 1.012 | -0.9738 | -0.9526 | -0.9453 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9330 | -0.5604 | -0.5995 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8885 | 0.5071 | -0.6698 | -0.4911 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1626 | -0.4353 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.23061 | 101.2 | -4.074 | -0.9525 | -2.378 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8566 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6889 | 3.791 | 1.553 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.23061</span> | 101.2 | 0.01701 | 0.2784 | 0.09274 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8566 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6889 | 3.791 | 1.553 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.556 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 126</span>| 468.22552 | 1.012 | -0.9738 | -0.9506 | -0.9419 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9573 | -0.9333 | -0.5606 | -0.5998 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8861 | 0.5138 | -0.6689 | -0.4912 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1606 | -0.4347 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.22552 | 101.2 | -4.074 | -0.9506 | -2.375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01113 | 0.8565 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6906 | 3.802 | 1.554 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.22552</span> | 101.2 | 0.01701 | 0.2788 | 0.09305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8565 | 0.07773 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6906 | 3.802 | 1.554 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.559 | 1.685 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 127</span>| 468.21689 | 1.012 | -0.9737 | -0.9426 | -0.9286 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9574 | -0.9344 | -0.5614 | -0.6009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8763 | 0.5405 | -0.6653 | -0.4919 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1525 | -0.4325 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.21689 | 101.2 | -4.074 | -0.9431 | -2.361 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01114 | 0.8562 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6972 | 3.844 | 1.558 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.571 | 1.688 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.21689</span> | 101.2 | 0.01701 | 0.2803 | 0.09430 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8562 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.6972 | 3.844 | 1.558 | 1.620 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.571 | 1.688 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.525 | 0.5842 | 0.4183 | 0.9468 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.5439 | 0.008618 | -1.874 | -1.936 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2463 | -0.5498 | 0.04440 | -0.1490 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.2038 | -0.1015 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 128</span>| 468.19158 | 1.011 | -0.9737 | -0.9504 | -0.9293 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9577 | -0.9362 | -0.5600 | -0.6009 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8523 | 0.5756 | -0.6644 | -0.4878 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1417 | -0.4298 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.19158 | 101.1 | -4.074 | -0.9504 | -2.362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01116 | 0.8567 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7134 | 3.900 | 1.560 | 1.624 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.691 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.19158</span> | 101.1 | 0.01701 | 0.2788 | 0.09423 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8567 | 0.07769 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7134 | 3.900 | 1.560 | 1.624 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.691 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -7.990 | 0.8226 | -0.02734 | 0.9308 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.6358 | 0.008756 | -3.089 | -2.706 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.08468 | -0.5047 | 0.1760 | -0.08785 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.06839 | -0.06706 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 129</span>| 468.16872 | 1.012 | -0.9746 | -0.9536 | -0.9297 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9583 | -0.9383 | -0.5551 | -0.6021 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8428 | 0.6190 | -0.6652 | -0.4874 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1424 | -0.4276 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.16872 | 101.2 | -4.075 | -0.9534 | -2.362 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.058 | -0.01118 | 0.8585 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7198 | 3.968 | 1.559 | 1.625 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.586 | 1.694 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.16872</span> | 101.2 | 0.01700 | 0.2782 | 0.09420 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01728 | 0.4972 | 0.8585 | 0.07765 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7198 | 3.968 | 1.559 | 1.625 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.586 | 1.694 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 1.949 | 1.224 | -0.09904 | 0.8335 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8902 | 0.008091 | -1.732 | -1.975 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.02618 | -0.4349 | 0.2067 | -0.1419 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.09587 | -0.05531 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 130</span>| 468.14579 | 1.011 | -0.9759 | -0.9465 | -0.9356 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9407 | -0.5519 | -0.5999 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8420 | 0.6626 | -0.6664 | -0.4855 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1418 | -0.4273 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.14579 | 101.1 | -4.076 | -0.9467 | -2.368 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01121 | 0.8597 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.037 | 1.557 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.694 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.14579</span> | 101.1 | 0.01698 | 0.2795 | 0.09364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4972 | 0.8597 | 0.07772 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.037 | 1.557 | 1.627 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.587 | 1.694 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -9.402 | -0.5832 | 0.1847 | 0.5188 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4155 | 0.008564 | -1.671 | -1.980 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.03632 | -0.3649 | 0.3304 | -0.09551 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1039 | -0.08698 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 131</span>| 468.12514 | 1.011 | -0.9763 | -0.9445 | -0.9403 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9555 | -0.9442 | -0.5537 | -0.5953 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8391 | 0.7059 | -0.6668 | -0.4805 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1376 | -0.4223 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.12514 | 101.1 | -4.076 | -0.9449 | -2.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01125 | 0.8590 | 0.07788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7223 | 4.106 | 1.557 | 1.633 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.593 | 1.700 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.12514</span> | 101.1 | 0.01697 | 0.2799 | 0.09320 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01733 | 0.4972 | 0.8590 | 0.07788 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7223 | 4.106 | 1.557 | 1.633 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.593 | 1.700 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -5.823 | -0.4010 | 0.3316 | 0.1628 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2993 | 0.008766 | -1.373 | -1.049 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.008284 | -0.3402 | 0.4029 | 0.04088 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.03436 | -0.04680 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 132</span>| 468.10920 | 1.012 | -0.9773 | -0.9503 | -0.9395 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9556 | -0.9476 | -0.5516 | -0.5942 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8420 | 0.7499 | -0.6684 | -0.4836 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1347 | -0.4216 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.1092 | 101.2 | -4.077 | -0.9504 | -2.372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01129 | 0.8598 | 0.07791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.175 | 1.555 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.597 | 1.700 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.1092</span> | 101.2 | 0.01695 | 0.2788 | 0.09328 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01732 | 0.4972 | 0.8598 | 0.07791 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7204 | 4.175 | 1.555 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.597 | 1.700 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 0.4262 | -0.09925 | 0.1213 | 0.1364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.2200 | 0.008054 | -0.8480 | -0.9224 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.002683 | -0.2932 | 0.3866 | -0.06974 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01820 | -0.05063 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 133</span>| 468.09766 | 1.011 | -0.9774 | -0.9506 | -0.9392 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9564 | -0.9508 | -0.5497 | -0.5929 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8318 | 0.7901 | -0.6724 | -0.4776 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1474 | -0.4133 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.09766 | 101.1 | -4.077 | -0.9507 | -2.372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.056 | -0.01132 | 0.8605 | 0.07796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7273 | 4.239 | 1.550 | 1.636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.578 | 1.710 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.09766</span> | 101.1 | 0.01695 | 0.2788 | 0.09331 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01731 | 0.4972 | 0.8605 | 0.07796 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7273 | 4.239 | 1.550 | 1.636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.578 | 1.710 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -1.610 | 0.04645 | 0.08092 | 0.1870 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1143 | 0.008788 | -0.7906 | -0.9380 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.03576 | -0.2567 | 0.2790 | 0.04583 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1853 | 0.03622 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 134</span>| 468.08577 | 1.011 | -0.9779 | -0.9521 | -0.9394 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9569 | -0.9550 | -0.5484 | -0.5900 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8316 | 0.8332 | -0.6752 | -0.4781 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1428 | -0.4231 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.08577 | 101.1 | -4.078 | -0.9520 | -2.372 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01137 | 0.8610 | 0.07805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7274 | 4.307 | 1.546 | 1.635 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.585 | 1.699 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.08577</span> | 101.1 | 0.01694 | 0.2785 | 0.09329 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4972 | 0.8610 | 0.07805 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7274 | 4.307 | 1.546 | 1.635 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.585 | 1.699 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -2.835 | -0.08271 | 0.01028 | 0.1502 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.2859 | 0.008536 | -0.7298 | -0.7597 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.09519 | -0.2281 | 0.1720 | -0.01715 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1386 | -0.1062 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 135</span>| 468.06947 | 1.011 | -0.9795 | -0.9573 | -0.9407 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9575 | -0.9652 | -0.5443 | -0.5834 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8515 | 0.9153 | -0.6785 | -0.4834 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1291 | -0.4003 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.06947 | 101.1 | -4.080 | -0.9569 | -2.373 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01148 | 0.8625 | 0.07827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7139 | 4.437 | 1.542 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.605 | 1.725 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.06947</span> | 101.1 | 0.01692 | 0.2775 | 0.09316 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01729 | 0.4971 | 0.8625 | 0.07827 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7139 | 4.437 | 1.542 | 1.629 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.605 | 1.725 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | -3.887 | -0.6407 | -0.1939 | 0.08469 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.4208 | 0.006503 | -1.301 | -1.072 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1255 | -0.1861 | 0.1431 | -0.06050 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.01658 | 0.1111 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 136</span>| 468.05012 | 1.012 | -0.9812 | -0.9547 | -0.9420 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9873 | -0.5356 | -0.5736 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8556 | 1.092 | -0.6884 | -0.4796 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1211 | -0.3873 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.05012 | 101.2 | -4.081 | -0.9544 | -2.375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01172 | 0.8656 | 0.07860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05012</span> | 101.2 | 0.01689 | 0.2780 | 0.09305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4971 | 0.8656 | 0.07860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | F| Forward Diff. | 2.331 | -0.3124 | 0.04539 | -0.09325 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.3359 | 0.005628 | -0.9294 | -0.4404 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.1788 | -0.1003 | -0.1180 | -0.02636 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 0.09915 | 0.1820 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 137</span>| 468.05341 | 1.012 | -0.9836 | -0.9687 | -0.9317 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9507 | -1.013 | -0.5235 | -0.5660 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8472 | 1.268 | -0.6904 | -0.4754 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1200 | -0.3857 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.05341 | 101.2 | -4.084 | -0.9676 | -2.364 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.051 | -0.01201 | 0.8700 | 0.07886 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 4.995 | 1.527 | 1.639 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.619 | 1.742 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05341</span> | 101.2 | 0.01685 | 0.2754 | 0.09401 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01741 | 0.4970 | 0.8700 | 0.07886 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7168 | 4.995 | 1.527 | 1.639 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.619 | 1.742 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> |<span style="font-weight: bold;"> 138</span>| 468.05012 | 1.012 | -0.9812 | -0.9547 | -0.9420 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.9570 | -0.9873 | -0.5356 | -0.5736 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -0.8556 | 1.092 | -0.6884 | -0.4796 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| -0.1211 | -0.3873 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | U| 468.05012 | 101.2 | -4.081 | -0.9544 | -2.375 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| -4.057 | -0.01172 | 0.8656 | 0.07860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> | X|<span style="font-weight: bold;"> 468.05012</span> | 101.2 | 0.01689 | 0.2780 | 0.09305 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.01730 | 0.4971 | 0.8656 | 0.07860 |</span> -<span class="r-out co"><span class="r-pr">#></span> |.....................| 0.7112 | 4.716 | 1.529 | 1.634 |</span> -<span class="r-out co"><span class="r-pr">#></span> <span style="text-decoration: underline;">|.....................| 2.617 | 1.740 |...........|...........|</span></span> -<span class="r-out co"><span class="r-pr">#></span> calculating covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> done</span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating residuals/tables</span> -<span class="r-msg co"><span class="r-pr">#></span> done</span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/r/stats/AIC.html" class="external-link">AIC</a></span><span class="op">(</span><span class="va">f_nlmixr_dfop_sfo_saem</span><span class="op">$</span><span class="va">nm</span>, <span class="va">f_nlmixr_dfop_sfo_focei</span><span class="op">$</span><span class="va">nm</span><span class="op">)</span></span> -<span class="r-msg co"><span class="r-pr">#></span> Calculating -2LL by Gaussian quadrature (nnodes=3,nsd=1.6)</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> df AIC</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_saem$nm 16 1105.3725</span> -<span class="r-out co"><span class="r-pr">#></span> f_nlmixr_dfop_sfo_focei$nm 14 810.3271</span> -<span class="r-in"><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_nlmixr_dfop_sfo_sfo</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span class="r-err co"><span class="r-pr">#></span> <span class="error">Error in h(simpleError(msg, call)):</span> error in evaluating the argument 'object' in selecting a method for function 'summary': object 'f_nlmixr_dfop_sfo_sfo' not found</span> -<span class="r-in"><span class="co"># }</span></span> -<span class="r-in"></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary.saem.mmkin.html b/docs/dev/reference/summary.saem.mmkin.html deleted file mode 100644 index e434ad8d..00000000 --- a/docs/dev/reference/summary.saem.mmkin.html +++ /dev/null @@ -1,677 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" 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property="og:title" content="Summary method for class " saem.mmkin summary.saem.mmkin><meta property="og:description" content="Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Summary method for class "saem.mmkin"</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/summary.saem.mmkin.R" class="external-link"><code>R/summary.saem.mmkin.R</code></a></small> - <div class="hidden name"><code>summary.saem.mmkin.Rd</code></div> - </div> - - <div class="ref-description"> - <p>Lists model equations, initial parameter values, optimised parameters -for fixed effects (population), random effects (deviations from the -population mean) and residual error model, as well as the resulting -endpoints such as formation fractions and DT50 values. Optionally -(default is FALSE), the data are listed in full.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span></span> -<span> <span class="va">object</span>,</span> -<span> data <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> verbose <span class="op">=</span> <span class="cn">FALSE</span>,</span> -<span> covariates <span class="op">=</span> <span class="cn">NULL</span>,</span> -<span> covariate_quantile <span class="op">=</span> <span class="fl">0.5</span>,</span> -<span> distimes <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> <span class="va">...</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="co"># S3 method for summary.saem.mmkin</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">x</span>, digits <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/Extremes.html" class="external-link">max</a></span><span class="op">(</span><span class="fl">3</span>, <span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">getOption</a></span><span class="op">(</span><span class="st">"digits"</span><span class="op">)</span> <span class="op">-</span> <span class="fl">3</span><span class="op">)</span>, verbose <span class="op">=</span> <span class="va">x</span><span class="op">$</span><span class="va">verbose</span>, <span class="va">...</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>an object of class <a href="saem.html">saem.mmkin</a></p></dd> - - -<dt>data</dt> -<dd><p>logical, indicating whether the full data should be included in -the summary.</p></dd> - - -<dt>verbose</dt> -<dd><p>Should the summary be verbose?</p></dd> - - -<dt>covariates</dt> -<dd><p>Numeric vector with covariate values for all variables in -any covariate models in the object. If given, it overrides 'covariate_quantile'.</p></dd> - - -<dt>covariate_quantile</dt> -<dd><p>This argument only has an effect if the fitted -object has covariate models. If so, the default is to show endpoints -for the median of the covariate values (50th percentile).</p></dd> - - -<dt>distimes</dt> -<dd><p>logical, indicating whether DT50 and DT90 values should be -included.</p></dd> - - -<dt>...</dt> -<dd><p>optional arguments passed to methods like <code>print</code>.</p></dd> - - -<dt>x</dt> -<dd><p>an object of class summary.saem.mmkin</p></dd> - - -<dt>digits</dt> -<dd><p>Number of digits to use for printing</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>The summary function returns a list based on the <a href="https://rdrr.io/pkg/saemix/man/SaemixObject-class.html" class="external-link">saemix::SaemixObject</a></p> - - -<p>obtained in the fit, with at least the following additional components</p> -<dl><dt>saemixversion, mkinversion, Rversion</dt> -<dd><p>The saemix, mkin and R versions used</p></dd> - -<dt>date.fit, date.summary</dt> -<dd><p>The dates where the fit and the summary were -produced</p></dd> - -<dt>diffs</dt> -<dd><p>The differential equations used in the degradation model</p></dd> - -<dt>use_of_ff</dt> -<dd><p>Was maximum or minimum use made of formation fractions</p></dd> - -<dt>data</dt> -<dd><p>The data</p></dd> - -<dt>confint_trans</dt> -<dd><p>Transformed parameters as used in the optimisation, with confidence intervals</p></dd> - -<dt>confint_back</dt> -<dd><p>Backtransformed parameters, with confidence intervals if available</p></dd> - -<dt>confint_errmod</dt> -<dd><p>Error model parameters with confidence intervals</p></dd> - -<dt>ff</dt> -<dd><p>The estimated formation fractions derived from the fitted -model.</p></dd> - -<dt>distimes</dt> -<dd><p>The DT50 and DT90 values for each observed variable.</p></dd> - -<dt>SFORB</dt> -<dd><p>If applicable, eigenvalues of SFORB components of the model.</p></dd> - -</dl><p>The print method is called for its side effect, i.e. printing the summary.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke for the mkin specific parts -saemix authors for the parts inherited from saemix.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># Generate five datasets following DFOP-SFO kinetics</span></span></span> -<span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"DFOP"</span>, <span class="st">"m1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/Random.html" class="external-link">set.seed</a></span><span class="op">(</span><span class="fl">1234</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">k1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.1</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">k2_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">g_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.5</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_parent_to_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">plogis</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/stats/Normal.html" class="external-link">rnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">qlogis</a></span><span class="op">(</span><span class="fl">0.3</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">k_m1_in</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/Lognormal.html" class="external-link">rlnorm</a></span><span class="op">(</span><span class="fl">5</span>, <span class="fu"><a href="https://rdrr.io/r/base/Log.html" class="external-link">log</a></span><span class="op">(</span><span class="fl">0.02</span><span class="op">)</span>, <span class="fl">0.3</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">pred_dfop_sfo</span> <span class="op"><-</span> <span class="kw">function</span><span class="op">(</span><span class="va">k1</span>, <span class="va">k2</span>, <span class="va">g</span>, <span class="va">f_parent_to_m1</span>, <span class="va">k_m1</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1</span>, k2 <span class="op">=</span> <span class="va">k2</span>, g <span class="op">=</span> <span class="va">g</span>, f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1</span>, k_m1 <span class="op">=</span> <span class="va">k_m1</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">ds_mean_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">5</span>, <span class="kw">function</span><span class="op">(</span><span class="va">i</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">dfop_sfo</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="va">k1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k2 <span class="op">=</span> <span class="va">k2_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, g <span class="op">=</span> <span class="va">g_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>,</span></span> -<span class="r-in"><span> f_parent_to_m1 <span class="op">=</span> <span class="va">f_parent_to_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span>, k_m1 <span class="op">=</span> <span class="va">k_m1_in</span><span class="op">[</span><span class="va">i</span><span class="op">]</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, m1 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="st">"ds"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">5</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">ds_syn_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/lapply.html" class="external-link">lapply</a></span><span class="op">(</span><span class="va">ds_mean_dfop_sfo</span>, <span class="kw">function</span><span class="op">(</span><span class="va">ds</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">ds</span>,</span></span> -<span class="r-in"><span> sdfunc <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="fl">1</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="fl">0.07</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> n <span class="op">=</span> <span class="fl">1</span><span class="op">)</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span></span></span> -<span class="r-in"><span><span class="op">}</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># Evaluate using mmkin and saem</span></span></span> -<span class="r-in"><span><span class="va">f_mmkin_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="mmkin.html">mmkin</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span><span class="va">dfop_sfo</span><span class="op">)</span>, <span class="va">ds_syn_dfop_sfo</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span>, error_model <span class="op">=</span> <span class="st">"tc"</span>, cores <span class="op">=</span> <span class="fl">5</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">f_saem_dfop_sfo</span> <span class="op"><-</span> <span class="fu"><a href="saem.html">saem</a></span><span class="op">(</span><span class="va">f_mmkin_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Kinetic nonlinear mixed-effects model fit by SAEM</span> -<span class="r-out co"><span class="r-pr">#></span> Structural model:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> -<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_m1 * m1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 171 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood computed by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 810.8 805.4 -391.4</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> estimate lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 100.86947 97.81542 103.92353</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -4.06947 -4.16944 -3.96950</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.93256 -1.34200 -0.52312</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.37017 -2.72660 -2.01375</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 -4.06264 -4.21344 -3.91184</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.02174 -0.45898 0.41549</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.87598 0.67275 1.07922</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.07949 0.06389 0.09509</span> -<span class="r-out co"><span class="r-pr">#></span> SD.parent_0 0.19170 -30.36286 30.74626</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k_m1 0.01883 -0.28736 0.32502</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.44300 0.16391 0.72209</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 0.35320 0.09661 0.60978</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 0.13707 0.02359 0.25056</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.37478 0.04490 0.70467</span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] "sd(parent_0)" "sd(log_k_m1)"</span> -<span class="r-in"><span><span class="va">f_saem_dfop_sfo_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>,</span></span> -<span class="r-in"><span> no_random_effect <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"parent_0"</span>, <span class="st">"log_k_m1"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="illparms.html">illparms</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo_2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Approximate 95% confidence intervals</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 98.36731429 101.42508066 104.48284703</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.01513234 0.01670094 0.01843214</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.20221431 0.27608850 0.36461630</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.06915073 0.09759718 0.13774560</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.01487068 0.01740389 0.02036863</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.37365671 0.48384821 0.59563299</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> sd(f_parent_qlogis) 0.16439770 0.4427585 0.7211193</span> -<span class="r-out co"><span class="r-pr">#></span> sd(log_k1) 0.08304243 0.3345213 0.5860002</span> -<span class="r-out co"><span class="r-pr">#></span> sd(log_k2) 0.03146410 0.1490210 0.2665779</span> -<span class="r-out co"><span class="r-pr">#></span> sd(g_qlogis) 0.06216385 0.4023430 0.7425221</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.67696663 0.87777355 1.07858048</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.06363957 0.07878001 0.09392044</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo_2</span>, data <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> saemix version used for fitting: 3.2 </span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for pre-fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:34:58 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:34:58 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - ((k1 * g * exp(-k1 * time) + k2 * (1 - g) * exp(-k2 *</span> -<span class="r-out co"><span class="r-pr">#></span> time)) / (g * exp(-k1 * time) + (1 - g) * exp(-k2 * time)))</span> -<span class="r-out co"><span class="r-pr">#></span> * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_m1/dt = + f_parent_to_m1 * ((k1 * g * exp(-k1 * time) + k2 * (1 - g)</span> -<span class="r-out co"><span class="r-pr">#></span> * exp(-k2 * time)) / (g * exp(-k1 * time) + (1 - g) *</span> -<span class="r-out co"><span class="r-pr">#></span> exp(-k2 * time))) * parent - k_m1 * m1</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> 171 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type analytical </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted in 9.384 s</span> -<span class="r-out co"><span class="r-pr">#></span> Using 300, 100 iterations and 10 chains</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model: Two-component variance function </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for degradation parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 </span> -<span class="r-out co"><span class="r-pr">#></span> 101.65645 -4.05368 -0.94311 -2.35943 -4.07006 </span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis </span> -<span class="r-out co"><span class="r-pr">#></span> -0.01132 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed degradation parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> None</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for random effects (square root of initial entries in omega):</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_m1 f_parent_qlogis log_k1 log_k2 g_qlogis</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 6.742 0.0000 0.0000 0.0000 0.0000 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 0.000 0.2236 0.0000 0.0000 0.0000 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000 0.0000 0.5572 0.0000 0.0000 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 0.000 0.0000 0.0000 0.8031 0.0000 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 0.000 0.0000 0.0000 0.0000 0.2931 0.000</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis 0.000 0.0000 0.0000 0.0000 0.0000 0.807</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for error model parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 b.1 </span> -<span class="r-out co"><span class="r-pr">#></span> 1 1 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Likelihood computed by importance sampling</span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 807 802.3 -391.5</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.42508 98.36731 104.48285</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -4.09229 -4.19092 -3.99366</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.96395 -1.37251 -0.55538</span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 -2.32691 -2.67147 -1.98235</span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 -4.05106 -4.20836 -3.89376</span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis -0.06463 -0.51656 0.38730</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.87777 0.67697 1.07858</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.07878 0.06364 0.09392</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.44276 0.16440 0.72112</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 0.33452 0.08304 0.58600</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 0.14902 0.03146 0.26658</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.40234 0.06216 0.74252</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Correlation: </span> -<span class="r-out co"><span class="r-pr">#></span> parnt_0 lg_k_m1 f_prnt_ log_k1 log_k2 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -0.4693 </span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -0.2378 0.2595 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k1 0.1720 -0.1593 -0.0669 </span> -<span class="r-out co"><span class="r-pr">#></span> log_k2 0.0179 0.0594 0.0035 0.1995 </span> -<span class="r-out co"><span class="r-pr">#></span> g_qlogis 0.1073 -0.1060 -0.0322 -0.2299 -0.3168</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> SD.f_parent_qlogis 0.4428 0.16440 0.7211</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k1 0.3345 0.08304 0.5860</span> -<span class="r-out co"><span class="r-pr">#></span> SD.log_k2 0.1490 0.03146 0.2666</span> -<span class="r-out co"><span class="r-pr">#></span> SD.g_qlogis 0.4023 0.06216 0.7425</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Variance model:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.87777 0.67697 1.07858</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.07878 0.06364 0.09392</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> est. lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.4251 98.36731 104.48285</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0167 0.01513 0.01843</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.2761 0.20221 0.36462</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.0976 0.06915 0.13775</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.0174 0.01487 0.02037</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.4838 0.37366 0.59563</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_m1 0.2761</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.7239</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90 DT50back DT50_k1 DT50_k2</span> -<span class="r-out co"><span class="r-pr">#></span> parent 15.54 94.33 28.4 7.102 39.83</span> -<span class="r-out co"><span class="r-pr">#></span> m1 41.50 137.87 NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> ds name time observed predicted residual std standardized</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 89.8 1.014e+02 -11.62508 8.0383 -1.44620</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 0 104.1 1.014e+02 2.67492 8.0383 0.33277</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 88.7 9.650e+01 -7.80311 7.6530 -1.01961</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 1 95.5 9.650e+01 -1.00311 7.6530 -0.13107</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 81.8 8.753e+01 -5.72638 6.9510 -0.82382</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 3 94.5 8.753e+01 6.97362 6.9510 1.00326</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 71.5 7.254e+01 -1.04133 5.7818 -0.18010</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 7 70.3 7.254e+01 -2.24133 5.7818 -0.38765</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 54.2 5.349e+01 0.71029 4.3044 0.16502</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 14 49.6 5.349e+01 -3.88971 4.3044 -0.90366</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 31.5 3.167e+01 -0.16616 2.6446 -0.06283</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 28 28.8 3.167e+01 -2.86616 2.6446 -1.08379</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 12.1 1.279e+01 -0.69287 1.3365 -0.51843</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 60 13.6 1.279e+01 0.80713 1.3365 0.60392</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 6.2 6.397e+00 -0.19718 1.0122 -0.19481</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 90 8.3 6.397e+00 1.90282 1.0122 1.87996</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 2.2 3.323e+00 -1.12320 0.9160 -1.22623</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 parent 120 2.4 3.323e+00 -0.92320 0.9160 -1.00788</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 1 0.3 1.179e+00 -0.87919 0.8827 -0.99605</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 1 0.2 1.179e+00 -0.97919 0.8827 -1.10935</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 3 2.2 3.273e+00 -1.07272 0.9149 -1.17256</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 3 3.0 3.273e+00 -0.27272 0.9149 -0.29811</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 7 6.5 6.559e+00 -0.05872 1.0186 -0.05765</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 7 5.0 6.559e+00 -1.55872 1.0186 -1.53032</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 14 10.2 1.016e+01 0.03787 1.1880 0.03188</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 14 9.5 1.016e+01 -0.66213 1.1880 -0.55734</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 28 12.2 1.268e+01 -0.47913 1.3297 -0.36032</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 28 13.4 1.268e+01 0.72087 1.3297 0.54211</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 60 11.8 1.078e+01 1.02493 1.2211 0.83936</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 60 13.2 1.078e+01 2.42493 1.2211 1.98588</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 90 6.6 7.705e+00 -1.10464 1.0672 -1.03509</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 90 9.3 7.705e+00 1.59536 1.0672 1.49491</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 120 3.5 5.236e+00 -1.73617 0.9699 -1.79010</span> -<span class="r-out co"><span class="r-pr">#></span> ds 1 m1 120 5.4 5.236e+00 0.16383 0.9699 0.16892</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 118.0 1.014e+02 16.57492 8.0383 2.06198</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 0 99.8 1.014e+02 -1.62508 8.0383 -0.20217</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 90.2 9.599e+01 -5.79045 7.6129 -0.76061</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 1 94.6 9.599e+01 -1.39045 7.6129 -0.18264</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 96.1 8.652e+01 9.57931 6.8724 1.39388</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 3 78.4 8.652e+01 -8.12069 6.8724 -1.18164</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 77.9 7.197e+01 5.93429 5.7370 1.03439</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 7 77.7 7.197e+01 5.73429 5.7370 0.99953</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 56.0 5.555e+01 0.44657 4.4637 0.10005</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 14 54.7 5.555e+01 -0.85343 4.4637 -0.19120</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 36.6 3.853e+01 -1.93170 3.1599 -0.61132</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 28 36.8 3.853e+01 -1.73170 3.1599 -0.54803</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 22.1 2.110e+01 1.00360 1.8795 0.53396</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 60 24.7 2.110e+01 3.60360 1.8795 1.91728</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 12.4 1.250e+01 -0.09712 1.3190 -0.07363</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 90 10.8 1.250e+01 -1.69712 1.3190 -1.28667</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 6.8 7.419e+00 -0.61913 1.0546 -0.58709</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 parent 120 7.9 7.419e+00 0.48087 1.0546 0.45599</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 1 1.3 1.422e+00 -0.12194 0.8849 -0.13781</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 3 3.7 3.831e+00 -0.13149 0.9282 -0.14166</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 3 4.7 3.831e+00 0.86851 0.9282 0.93567</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 7 8.1 7.292e+00 0.80812 1.0490 0.77034</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 7 7.9 7.292e+00 0.60812 1.0490 0.57969</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 14 10.1 1.055e+01 -0.45332 1.2090 -0.37495</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 14 10.3 1.055e+01 -0.25332 1.2090 -0.20953</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 28 10.7 1.230e+01 -1.59960 1.3074 -1.22347</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 28 12.2 1.230e+01 -0.09960 1.3074 -0.07618</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 60 10.7 1.065e+01 0.05342 1.2141 0.04400</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 60 12.5 1.065e+01 1.85342 1.2141 1.52661</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 90 9.1 8.196e+00 0.90368 1.0897 0.82930</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 90 7.4 8.196e+00 -0.79632 1.0897 -0.73078</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 120 6.1 5.997e+00 0.10252 0.9969 0.10284</span> -<span class="r-out co"><span class="r-pr">#></span> ds 2 m1 120 4.5 5.997e+00 -1.49748 0.9969 -1.50220</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 106.2 1.014e+02 4.77492 8.0383 0.59402</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 0 106.9 1.014e+02 5.47492 8.0383 0.68110</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 107.4 9.390e+01 13.49935 7.4494 1.81214</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 1 96.1 9.390e+01 2.19935 7.4494 0.29524</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 79.4 8.152e+01 -2.12307 6.4821 -0.32753</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 3 82.6 8.152e+01 1.07693 6.4821 0.16614</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 63.9 6.446e+01 -0.55834 5.1533 -0.10834</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 7 62.4 6.446e+01 -2.05834 5.1533 -0.39942</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 51.0 4.826e+01 2.74073 3.9019 0.70241</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 14 47.1 4.826e+01 -1.15927 3.9019 -0.29711</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 36.1 3.424e+01 1.86399 2.8364 0.65718</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 28 36.6 3.424e+01 2.36399 2.8364 0.83346</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 20.1 1.968e+01 0.42172 1.7815 0.23672</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 60 19.8 1.968e+01 0.12172 1.7815 0.06833</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 11.3 1.195e+01 -0.64633 1.2869 -0.50222</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 90 10.7 1.195e+01 -1.24633 1.2869 -0.96844</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 8.2 7.255e+00 0.94532 1.0474 0.90251</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 parent 120 7.3 7.255e+00 0.04532 1.0474 0.04327</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 0 0.8 2.956e-11 0.80000 0.8778 0.91140</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 1 1.8 1.758e+00 0.04187 0.8886 0.04712</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 1 2.3 1.758e+00 0.54187 0.8886 0.60978</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 3 4.2 4.567e+00 -0.36697 0.9486 -0.38683</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 3 4.1 4.567e+00 -0.46697 0.9486 -0.49224</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 7 6.8 8.151e+00 -1.35124 1.0876 -1.24242</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 7 10.1 8.151e+00 1.94876 1.0876 1.79182</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 14 11.4 1.083e+01 0.57098 1.2240 0.46647</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 14 12.8 1.083e+01 1.97098 1.2240 1.61022</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 28 11.5 1.147e+01 0.03175 1.2597 0.02520</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 28 10.6 1.147e+01 -0.86825 1.2597 -0.68928</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 60 7.5 9.298e+00 -1.79834 1.1433 -1.57298</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 60 8.6 9.298e+00 -0.69834 1.1433 -0.61083</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 90 7.3 7.038e+00 0.26249 1.0382 0.25283</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 90 8.1 7.038e+00 1.06249 1.0382 1.02340</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 120 5.3 5.116e+00 0.18417 0.9659 0.19068</span> -<span class="r-out co"><span class="r-pr">#></span> ds 3 m1 120 3.8 5.116e+00 -1.31583 0.9659 -1.36232</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 104.7 1.014e+02 3.27492 8.0383 0.40741</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 0 88.3 1.014e+02 -13.12508 8.0383 -1.63281</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 94.2 9.781e+01 -3.61183 7.7555 -0.46572</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 1 94.6 9.781e+01 -3.21183 7.7555 -0.41414</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 78.1 9.110e+01 -13.00467 7.2307 -1.79853</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 3 96.5 9.110e+01 5.39533 7.2307 0.74617</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 76.2 7.951e+01 -3.30511 6.3246 -0.52258</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 7 77.8 7.951e+01 -1.70511 6.3246 -0.26960</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 70.8 6.376e+01 7.03783 5.0993 1.38016</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 14 67.3 6.376e+01 3.53783 5.0993 0.69379</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 43.1 4.340e+01 -0.30456 3.5303 -0.08627</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 28 45.1 4.340e+01 1.69544 3.5303 0.48026</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 21.3 2.142e+01 -0.12077 1.9022 -0.06349</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 60 23.5 2.142e+01 2.07923 1.9022 1.09308</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 11.8 1.207e+01 -0.26813 1.2940 -0.20721</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 90 12.1 1.207e+01 0.03187 1.2940 0.02463</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 7.0 6.954e+00 0.04554 1.0347 0.04402</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 parent 120 6.2 6.954e+00 -0.75446 1.0347 -0.72914</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 0 1.6 1.990e-13 1.60000 0.8778 1.82279</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 1 0.9 7.305e-01 0.16949 0.8797 0.19267</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 3 3.7 2.051e+00 1.64896 0.8925 1.84753</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 3 2.0 2.051e+00 -0.05104 0.8925 -0.05719</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 7 3.6 4.204e+00 -0.60375 0.9382 -0.64354</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 7 3.8 4.204e+00 -0.40375 0.9382 -0.43036</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 14 7.1 6.760e+00 0.34021 1.0267 0.33137</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 14 6.6 6.760e+00 -0.15979 1.0267 -0.15563</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 28 9.5 9.011e+00 0.48856 1.1289 0.43277</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 28 9.3 9.011e+00 0.28856 1.1289 0.25561</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 60 8.3 8.611e+00 -0.31077 1.1093 -0.28014</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 60 9.0 8.611e+00 0.38923 1.1093 0.35086</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 90 6.6 6.678e+00 -0.07753 1.0233 -0.07576</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 90 7.7 6.678e+00 1.02247 1.0233 0.99915</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 120 3.7 4.847e+00 -1.14679 0.9572 -1.19804</span> -<span class="r-out co"><span class="r-pr">#></span> ds 4 m1 120 3.5 4.847e+00 -1.34679 0.9572 -1.40698</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 110.4 1.014e+02 8.97492 8.0383 1.11651</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 0 112.1 1.014e+02 10.67492 8.0383 1.32800</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 93.5 9.466e+01 -1.16118 7.5089 -0.15464</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 1 91.0 9.466e+01 -3.66118 7.5089 -0.48758</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 71.0 8.302e+01 -12.01844 6.5988 -1.82130</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 3 89.7 8.302e+01 6.68156 6.5988 1.01254</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 60.4 6.563e+01 -5.22574 5.2440 -0.99652</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 7 59.1 6.563e+01 -6.52574 5.2440 -1.24442</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 56.5 4.727e+01 9.22621 3.8263 2.41128</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 14 47.0 4.727e+01 -0.27379 3.8263 -0.07156</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 30.2 3.103e+01 -0.83405 2.5977 -0.32108</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 28 23.9 3.103e+01 -7.13405 2.5977 -2.74634</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 17.0 1.800e+01 -0.99696 1.6675 -0.59787</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 60 18.7 1.800e+01 0.70304 1.6675 0.42161</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 11.3 1.167e+01 -0.36809 1.2710 -0.28961</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 90 11.9 1.167e+01 0.23191 1.2710 0.18246</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 9.0 7.595e+00 1.40496 1.0623 1.32256</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 parent 120 8.1 7.595e+00 0.50496 1.0623 0.47535</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 0 0.7 0.000e+00 0.70000 0.8778 0.79747</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 1 3.0 3.158e+00 -0.15799 0.9123 -0.17317</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 1 2.6 3.158e+00 -0.55799 0.9123 -0.61160</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 3 5.1 8.443e+00 -3.34286 1.1013 -3.03535</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 3 7.5 8.443e+00 -0.94286 1.1013 -0.85613</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 7 16.5 1.580e+01 0.69781 1.5232 0.45811</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 7 19.0 1.580e+01 3.19781 1.5232 2.09935</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 14 22.9 2.216e+01 0.73604 1.9543 0.37663</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 14 23.2 2.216e+01 1.03604 1.9543 0.53014</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 28 22.2 2.423e+01 -2.03128 2.1011 -0.96678</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 28 24.4 2.423e+01 0.16872 2.1011 0.08030</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 60 15.5 1.876e+01 -3.25610 1.7187 -1.89455</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 60 19.8 1.876e+01 1.04390 1.7187 0.60739</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 90 14.9 1.366e+01 1.23585 1.3890 0.88976</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 90 14.2 1.366e+01 0.53585 1.3890 0.38579</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 120 10.9 9.761e+00 1.13911 1.1670 0.97613</span> -<span class="r-out co"><span class="r-pr">#></span> ds 5 m1 120 10.4 9.761e+00 0.63911 1.1670 0.54767</span> -<span class="r-in"><span><span class="co"># Add a correlation between random effects of g and k2</span></span></span> -<span class="r-in"><span><span class="va">cov_model_3</span> <span class="op"><-</span> <span class="va">f_saem_dfop_sfo_2</span><span class="op">$</span><span class="va">so</span><span class="op">@</span><span class="va">model</span><span class="op">@</span><span class="va">covariance.model</span></span></span> -<span class="r-in"><span><span class="va">cov_model_3</span><span class="op">[</span><span class="st">"log_k2"</span>, <span class="st">"g_qlogis"</span><span class="op">]</span> <span class="op"><-</span> <span class="fl">1</span></span></span> -<span class="r-in"><span><span class="va">cov_model_3</span><span class="op">[</span><span class="st">"g_qlogis"</span>, <span class="st">"log_k2"</span><span class="op">]</span> <span class="op"><-</span> <span class="fl">1</span></span></span> -<span class="r-in"><span><span class="va">f_saem_dfop_sfo_3</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>,</span></span> -<span class="r-in"><span> covariance.model <span class="op">=</span> <span class="va">cov_model_3</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/pkg/nlme/man/intervals.html" class="external-link">intervals</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo_3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Approximate 95% confidence intervals</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed effects:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 98.39888363 101.48951337 104.58014311</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.01508704 0.01665986 0.01839665</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.20141557 0.27540583 0.36418131</span> -<span class="r-out co"><span class="r-pr">#></span> k1 0.07708759 0.10430866 0.14114200</span> -<span class="r-out co"><span class="r-pr">#></span> k2 0.01476621 0.01786384 0.02161129</span> -<span class="r-out co"><span class="r-pr">#></span> g 0.33679867 0.45083525 0.57028162</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Random effects:</span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> sd(f_parent_qlogis) 0.38085375 0.4441841 0.5075145</span> -<span class="r-out co"><span class="r-pr">#></span> sd(log_k1) 0.04774819 0.2660384 0.4843286</span> -<span class="r-out co"><span class="r-pr">#></span> sd(log_k2) -0.63842736 0.1977024 1.0338321</span> -<span class="r-out co"><span class="r-pr">#></span> sd(g_qlogis) 0.22711289 0.4502227 0.6733326</span> -<span class="r-out co"><span class="r-pr">#></span> corr(log_k2,g_qlogis) -0.83271473 -0.6176939 -0.4026730</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> lower est. upper</span> -<span class="r-out co"><span class="r-pr">#></span> a.1 0.67347568 0.87437392 1.07527216</span> -<span class="r-out co"><span class="r-pr">#></span> b.1 0.06393032 0.07912417 0.09431802</span> -<span class="r-in"><span><span class="co"># The correlation does not improve the fit judged by AIC and BIC, although</span></span></span> -<span class="r-in"><span><span class="co"># the likelihood is higher with the additional parameter</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/stats/anova.html" class="external-link">anova</a></span><span class="op">(</span><span class="va">f_saem_dfop_sfo</span>, <span class="va">f_saem_dfop_sfo_2</span>, <span class="va">f_saem_dfop_sfo_3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Data: 171 observations of 2 variable(s) grouped in 5 datasets</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> npar AIC BIC Lik</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop_sfo_2 12 806.96 802.27 -391.48</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop_sfo_3 13 807.99 802.91 -391.00</span> -<span class="r-out co"><span class="r-pr">#></span> f_saem_dfop_sfo 14 810.83 805.36 -391.42</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/summary_listing.html b/docs/dev/reference/summary_listing.html deleted file mode 100644 index e584416a..00000000 --- a/docs/dev/reference/summary_listing.html +++ /dev/null @@ -1,164 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Display the output of a summary function according to the output format — summary_listing • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" 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code chunk with the chunk -option results = "asis".'><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" 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class="fu">summary_listing</span><span class="op">(</span><span class="va">object</span>, caption <span class="op">=</span> <span class="cn">NULL</span>, label <span class="op">=</span> <span class="cn">NULL</span>, clearpage <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">tex_listing</span><span class="op">(</span><span class="va">object</span>, caption <span class="op">=</span> <span class="cn">NULL</span>, label <span class="op">=</span> <span class="cn">NULL</span>, clearpage <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span> -<span></span> -<span><span class="fu">html_listing</span><span class="op">(</span><span class="va">object</span>, caption <span class="op">=</span> <span class="cn">NULL</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The object for which the summary is to be listed</p></dd> - - -<dt>caption</dt> -<dd><p>An optional caption</p></dd> - - -<dt>label</dt> -<dd><p>An optional label, ignored in html output</p></dd> - - -<dt>clearpage</dt> -<dd><p>Should a new page be started after the listing? Ignored in html output</p></dd> - -</dl></div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/synthetic_data_for_UBA_2014-1.png b/docs/dev/reference/synthetic_data_for_UBA_2014-1.png Binary files differdeleted file mode 100644 index 11eae1f9..00000000 --- a/docs/dev/reference/synthetic_data_for_UBA_2014-1.png +++ /dev/null diff --git a/docs/dev/reference/synthetic_data_for_UBA_2014.html b/docs/dev/reference/synthetic_data_for_UBA_2014.html deleted file mode 100644 index b8154c47..00000000 --- a/docs/dev/reference/synthetic_data_for_UBA_2014.html +++ /dev/null @@ -1,446 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014 • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Synthetic datasets for one parent compound with two metabolites — synthetic_data_for_UBA_2014"><meta property="og:description" content="The 12 datasets were generated using four different models and three different - variance components. The four models are either the SFO or the DFOP model with either - two sequential or two parallel metabolites. -Variance component 'a' is based on a normal distribution with standard deviation of 3, - Variance component 'b' is also based on a normal distribution, but with a standard deviation of 7. - Variance component 'c' is based on the error model from Rocke and Lorenzato (1995), with the - minimum standard deviation (for small y values) of 0.5, and a proportionality constant of 0.07 - for the increase of the standard deviation with y. Note that this is a simplified version - of the error model proposed by Rocke and Lorenzato (1995), as in their model the error of the - measured values approximates lognormal distribution for high values, whereas we are using - normally distributed error components all along. -Initial concentrations for metabolites and all values where adding the variance component resulted - in a value below the assumed limit of detection of 0.1 were set to NA. -As an example, the first dataset has the title SFO_lin_a and is based on the SFO model - with two sequential metabolites (linear pathway), with added variance component 'a'. -Compare also the code in the example section to see the degradation models."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Synthetic datasets for one parent compound with two metabolites</h1> - - <div class="hidden name"><code>synthetic_data_for_UBA_2014.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The 12 datasets were generated using four different models and three different - variance components. The four models are either the SFO or the DFOP model with either - two sequential or two parallel metabolites.</p> -<p>Variance component 'a' is based on a normal distribution with standard deviation of 3, - Variance component 'b' is also based on a normal distribution, but with a standard deviation of 7. - Variance component 'c' is based on the error model from Rocke and Lorenzato (1995), with the - minimum standard deviation (for small y values) of 0.5, and a proportionality constant of 0.07 - for the increase of the standard deviation with y. Note that this is a simplified version - of the error model proposed by Rocke and Lorenzato (1995), as in their model the error of the - measured values approximates lognormal distribution for high values, whereas we are using - normally distributed error components all along.</p> -<p>Initial concentrations for metabolites and all values where adding the variance component resulted - in a value below the assumed limit of detection of 0.1 were set to <code>NA</code>.</p> -<p>As an example, the first dataset has the title <code>SFO_lin_a</code> and is based on the SFO model - with two sequential metabolites (linear pathway), with added variance component 'a'.</p> -<p>Compare also the code in the example section to see the degradation models.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="va">synthetic_data_for_UBA_2014</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A list containing twelve datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>, - each containing, among others, the following components</p><dl><dt><code>title</code></dt> -<dd><p>The name of the dataset, e.g. <code>SFO_lin_a</code></p></dd> - - <dt><code>data</code></dt> -<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative - zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452</p> -<p>Rocke, David M. und Lorenzato, Stefan (1995) A two-component model for - measurement error in analytical chemistry. Technometrics 37(2), 176-184.</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># The data have been generated using the following kinetic models</span></span></span> -<span class="r-in"><span><span class="va">m_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">m_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">m_synth_DFOP_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="st">"M1"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">m_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"DFOP"</span>, to <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The model predictions without intentional error were generated as follows</span></span></span> -<span class="r-in"><span><span class="va">sampling_times</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fl">0</span>, <span class="fl">1</span>, <span class="fl">3</span>, <span class="fl">7</span>, <span class="fl">14</span>, <span class="fl">28</span>, <span class="fl">60</span>, <span class="fl">90</span>, <span class="fl">120</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d_synth_SFO_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.7</span>, f_parent_to_M1 <span class="op">=</span> <span class="fl">0.8</span>,</span></span> -<span class="r-in"><span> k_M1 <span class="op">=</span> <span class="fl">0.3</span>, f_M1_to_M2 <span class="op">=</span> <span class="fl">0.7</span>,</span></span> -<span class="r-in"><span> k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d_synth_DFOP_lin</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_DFOP_lin</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="fl">0.2</span>, k2 <span class="op">=</span> <span class="fl">0.02</span>, g <span class="op">=</span> <span class="fl">0.5</span>,</span></span> -<span class="r-in"><span> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.5</span>, k_M1 <span class="op">=</span> <span class="fl">0.3</span>,</span></span> -<span class="r-in"><span> f_M1_to_M2 <span class="op">=</span> <span class="fl">0.7</span>, k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d_synth_SFO_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_SFO_par</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k_parent <span class="op">=</span> <span class="fl">0.2</span>,</span></span> -<span class="r-in"><span> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.8</span>, k_M1 <span class="op">=</span> <span class="fl">0.01</span>,</span></span> -<span class="r-in"><span> f_parent_to_M2 <span class="op">=</span> <span class="fl">0.2</span>, k_M2 <span class="op">=</span> <span class="fl">0.02</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d_synth_DFOP_par</span> <span class="op"><-</span> <span class="fu"><a href="mkinpredict.html">mkinpredict</a></span><span class="op">(</span><span class="va">m_synth_DFOP_par</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>k1 <span class="op">=</span> <span class="fl">0.3</span>, k2 <span class="op">=</span> <span class="fl">0.02</span>, g <span class="op">=</span> <span class="fl">0.7</span>,</span></span> -<span class="r-in"><span> f_parent_to_M1 <span class="op">=</span> <span class="fl">0.6</span>, k_M1 <span class="op">=</span> <span class="fl">0.04</span>,</span></span> -<span class="r-in"><span> f_parent_to_M2 <span class="op">=</span> <span class="fl">0.4</span>, k_M2 <span class="op">=</span> <span class="fl">0.01</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fl">100</span>, M1 <span class="op">=</span> <span class="fl">0</span>, M2 <span class="op">=</span> <span class="fl">0</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> <span class="va">sampling_times</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Construct names for datasets with errors</span></span></span> -<span class="r-in"><span><span class="va">d_synth_names</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"d_synth_"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SFO_lin"</span>, <span class="st">"SFO_par"</span>,</span></span> -<span class="r-in"><span> <span class="st">"DFOP_lin"</span>, <span class="st">"DFOP_par"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Original function used or adding errors. The add_err function now published</span></span></span> -<span class="r-in"><span><span class="co"># with this package is a slightly generalised version where the names of</span></span></span> -<span class="r-in"><span><span class="co"># secondary compartments that should have an initial value of zero (M1 and M2</span></span></span> -<span class="r-in"><span><span class="co"># in this case) are not hardcoded any more.</span></span></span> -<span class="r-in"><span><span class="co"># add_err = function(d, sdfunc, LOD = 0.1, reps = 2, seed = 123456789)</span></span></span> -<span class="r-in"><span><span class="co"># {</span></span></span> -<span class="r-in"><span><span class="co"># set.seed(seed)</span></span></span> -<span class="r-in"><span><span class="co"># d_long = mkin_wide_to_long(d, time = "time")</span></span></span> -<span class="r-in"><span><span class="co"># d_rep = data.frame(lapply(d_long, rep, each = 2))</span></span></span> -<span class="r-in"><span><span class="co"># d_rep$value = rnorm(length(d_rep$value), d_rep$value, sdfunc(d_rep$value))</span></span></span> -<span class="r-in"><span><span class="co">#</span></span></span> -<span class="r-in"><span><span class="co"># d_rep[d_rep$time == 0 & d_rep$name %in% c("M1", "M2"), "value"] <- 0</span></span></span> -<span class="r-in"><span><span class="co"># d_NA <- transform(d_rep, value = ifelse(value < LOD, NA, value))</span></span></span> -<span class="r-in"><span><span class="co"># d_NA$value <- round(d_NA$value, 1)</span></span></span> -<span class="r-in"><span><span class="co"># return(d_NA)</span></span></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># The following is the simplified version of the two-component model of Rocke</span></span></span> -<span class="r-in"><span><span class="co"># and Lorenzato (1995)</span></span></span> -<span class="r-in"><span><span class="va">sdfunc_twocomp</span> <span class="op">=</span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span>, <span class="va">sd_low</span>, <span class="va">rsd_high</span><span class="op">)</span> <span class="op">{</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/MathFun.html" class="external-link">sqrt</a></span><span class="op">(</span><span class="va">sd_low</span><span class="op">^</span><span class="fl">2</span> <span class="op">+</span> <span class="va">value</span><span class="op">^</span><span class="fl">2</span> <span class="op">*</span> <span class="va">rsd_high</span><span class="op">^</span><span class="fl">2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Add the errors.</span></span></span> -<span class="r-in"><span><span class="kw">for</span> <span class="op">(</span><span class="va">d_synth_name</span> <span class="kw">in</span> <span class="va">d_synth_names</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">{</span></span></span> -<span class="r-in"><span> <span class="va">d_synth</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/get.html" class="external-link">get</a></span><span class="op">(</span><span class="va">d_synth_name</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_a"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">3</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_b"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>, <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fl">7</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/assign.html" class="external-link">assign</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="va">d_synth_name</span>, <span class="st">"_c"</span><span class="op">)</span>, <span class="fu"><a href="add_err.html">add_err</a></span><span class="op">(</span><span class="va">d_synth</span>,</span></span> -<span class="r-in"><span> <span class="kw">function</span><span class="op">(</span><span class="va">value</span><span class="op">)</span> <span class="fu">sdfunc_twocomp</span><span class="op">(</span><span class="va">value</span>, <span class="fl">0.5</span>, <span class="fl">0.07</span><span class="op">)</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="op">}</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">d_synth_err_names</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="va">d_synth_names</span>, each <span class="op">=</span> <span class="fl">3</span><span class="op">)</span>, <span class="va">letters</span><span class="op">[</span><span class="fl">1</span><span class="op">:</span><span class="fl">3</span><span class="op">]</span>, sep <span class="op">=</span> <span class="st">"_"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="op">)</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># This is just one example of an evaluation using the kinetic model used for</span></span></span> -<span class="r-in"><span><span class="co"># the generation of the data</span></span></span> -<span class="r-in"><span> <span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_synth_SFO_lin</span>, <span class="va">synthetic_data_for_UBA_2014</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>,</span></span> -<span class="r-in"><span> quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="synthetic_data_for_UBA_2014-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> mkin version used for fitting: 1.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> R version used for fitting: 4.2.3 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of fit: Sun Apr 16 08:35:08 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> Date of summary: Sun Apr 16 08:35:08 2023 </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Equations:</span> -<span class="r-out co"><span class="r-pr">#></span> d_parent/dt = - k_parent * parent</span> -<span class="r-out co"><span class="r-pr">#></span> d_M1/dt = + f_parent_to_M1 * k_parent * parent - k_M1 * M1</span> -<span class="r-out co"><span class="r-pr">#></span> d_M2/dt = + f_M1_to_M2 * k_M1 * M1 - k_M2 * M2</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Model predictions using solution type deSolve </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fitted using 833 model solutions performed in 0.166 s</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model: Constant variance </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Error model algorithm: OLS </span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for parameters to be optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.3500 state</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.1000 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> k_M1 0.1001 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> k_M2 0.1002 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.5000 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M2 0.5000 deparm</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Starting values for the transformed parameters actually optimised:</span> -<span class="r-out co"><span class="r-pr">#></span> value lower upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 101.350000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.302585 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -2.301586 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M2 -2.300587 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.000000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 0.000000 -Inf Inf</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Fixed parameter values:</span> -<span class="r-out co"><span class="r-pr">#></span> value type</span> -<span class="r-out co"><span class="r-pr">#></span> M1_0 0 state</span> -<span class="r-out co"><span class="r-pr">#></span> M2_0 0 state</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Results:</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> AIC BIC logLik</span> -<span class="r-out co"><span class="r-pr">#></span> 188.7274 200.3723 -87.36368</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Optimised, transformed parameters with symmetric confidence intervals:</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 102.1000 1.57000 98.8600 105.3000</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -0.3020 0.03885 -0.3812 -0.2229</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -1.2070 0.07123 -1.3520 -1.0620</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M2 -3.9010 0.06571 -4.0350 -3.7670</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 1.2010 0.23530 0.7216 1.6800</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 0.9589 0.24890 0.4520 1.4660</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.2730 0.25740 1.7490 2.7970</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Parameter correlation:</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent log_k_M1 log_k_M2 f_parent_qlogis</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.000e+00 3.933e-01 -1.605e-01 2.819e-02 -4.624e-01</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent 3.933e-01 1.000e+00 -4.082e-01 7.166e-02 -5.682e-01</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -1.605e-01 -4.082e-01 1.000e+00 -3.929e-01 7.478e-01</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M2 2.819e-02 7.166e-02 -3.929e-01 1.000e+00 -2.658e-01</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -4.624e-01 -5.682e-01 7.478e-01 -2.658e-01 1.000e+00</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 1.614e-01 4.102e-01 -8.109e-01 5.419e-01 -8.605e-01</span> -<span class="r-out co"><span class="r-pr">#></span> sigma -2.900e-08 -8.030e-09 -2.741e-08 3.938e-08 -2.681e-08</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis sigma</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 1.614e-01 -2.900e-08</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent 4.102e-01 -8.030e-09</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M1 -8.109e-01 -2.741e-08</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_M2 5.419e-01 3.938e-08</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis -8.605e-01 -2.681e-08</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_qlogis 1.000e+00 4.971e-08</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 4.971e-08 1.000e+00</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Backtransformed parameters:</span> -<span class="r-out co"><span class="r-pr">#></span> Confidence intervals for internally transformed parameters are asymmetric.</span> -<span class="r-out co"><span class="r-pr">#></span> t-test (unrealistically) based on the assumption of normal distribution</span> -<span class="r-out co"><span class="r-pr">#></span> for estimators of untransformed parameters.</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 102.10000 65.000 7.281e-36 98.86000 105.30000</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.73930 25.740 2.948e-23 0.68310 0.80020</span> -<span class="r-out co"><span class="r-pr">#></span> k_M1 0.29920 14.040 1.577e-15 0.25880 0.34590</span> -<span class="r-out co"><span class="r-pr">#></span> k_M2 0.02023 15.220 1.653e-16 0.01769 0.02312</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.76870 18.370 7.295e-19 0.67300 0.84290</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M2 0.72290 14.500 6.418e-16 0.61110 0.81240</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 2.27300 8.832 2.161e-10 1.74900 2.79700</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> FOCUS Chi2 error levels in percent:</span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 8.454 6 17</span> -<span class="r-out co"><span class="r-pr">#></span> parent 8.660 2 6</span> -<span class="r-out co"><span class="r-pr">#></span> M1 10.583 2 5</span> -<span class="r-out co"><span class="r-pr">#></span> M2 3.586 2 6</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Resulting formation fractions:</span> -<span class="r-out co"><span class="r-pr">#></span> ff</span> -<span class="r-out co"><span class="r-pr">#></span> parent_M1 0.7687</span> -<span class="r-out co"><span class="r-pr">#></span> parent_sink 0.2313</span> -<span class="r-out co"><span class="r-pr">#></span> M1_M2 0.7229</span> -<span class="r-out co"><span class="r-pr">#></span> M1_sink 0.2771</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Estimated disappearance times:</span> -<span class="r-out co"><span class="r-pr">#></span> DT50 DT90</span> -<span class="r-out co"><span class="r-pr">#></span> parent 0.9376 3.114</span> -<span class="r-out co"><span class="r-pr">#></span> M1 2.3170 7.697</span> -<span class="r-out co"><span class="r-pr">#></span> M2 34.2689 113.839</span> -<span class="r-out co"><span class="r-pr">#></span> </span> -<span class="r-out co"><span class="r-pr">#></span> Data:</span> -<span class="r-out co"><span class="r-pr">#></span> time variable observed predicted residual</span> -<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.5 1.021e+02 -0.56248</span> -<span class="r-out co"><span class="r-pr">#></span> 0 parent 101.2 1.021e+02 -0.86248</span> -<span class="r-out co"><span class="r-pr">#></span> 1 parent 53.9 4.873e+01 5.17118</span> -<span class="r-out co"><span class="r-pr">#></span> 1 parent 47.5 4.873e+01 -1.22882</span> -<span class="r-out co"><span class="r-pr">#></span> 3 parent 10.4 1.111e+01 -0.70773</span> -<span class="r-out co"><span class="r-pr">#></span> 3 parent 7.6 1.111e+01 -3.50773</span> -<span class="r-out co"><span class="r-pr">#></span> 7 parent 1.1 5.772e-01 0.52283</span> -<span class="r-out co"><span class="r-pr">#></span> 7 parent 0.3 5.772e-01 -0.27717</span> -<span class="r-out co"><span class="r-pr">#></span> 14 parent 3.5 3.264e-03 3.49674</span> -<span class="r-out co"><span class="r-pr">#></span> 28 parent 3.2 1.045e-07 3.20000</span> -<span class="r-out co"><span class="r-pr">#></span> 90 parent 0.6 9.530e-10 0.60000</span> -<span class="r-out co"><span class="r-pr">#></span> 120 parent 3.5 -5.940e-10 3.50000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 M1 36.4 3.479e+01 1.61088</span> -<span class="r-out co"><span class="r-pr">#></span> 1 M1 37.4 3.479e+01 2.61088</span> -<span class="r-out co"><span class="r-pr">#></span> 3 M1 34.3 3.937e+01 -5.07027</span> -<span class="r-out co"><span class="r-pr">#></span> 3 M1 39.8 3.937e+01 0.42973</span> -<span class="r-out co"><span class="r-pr">#></span> 7 M1 15.1 1.549e+01 -0.38715</span> -<span class="r-out co"><span class="r-pr">#></span> 7 M1 17.8 1.549e+01 2.31285</span> -<span class="r-out co"><span class="r-pr">#></span> 14 M1 5.8 1.995e+00 3.80469</span> -<span class="r-out co"><span class="r-pr">#></span> 14 M1 1.2 1.995e+00 -0.79531</span> -<span class="r-out co"><span class="r-pr">#></span> 60 M1 0.5 2.111e-06 0.50000</span> -<span class="r-out co"><span class="r-pr">#></span> 90 M1 3.2 -9.670e-10 3.20000</span> -<span class="r-out co"><span class="r-pr">#></span> 120 M1 1.5 7.670e-10 1.50000</span> -<span class="r-out co"><span class="r-pr">#></span> 120 M1 0.6 7.670e-10 0.60000</span> -<span class="r-out co"><span class="r-pr">#></span> 1 M2 4.8 4.455e+00 0.34517</span> -<span class="r-out co"><span class="r-pr">#></span> 3 M2 20.9 2.153e+01 -0.62527</span> -<span class="r-out co"><span class="r-pr">#></span> 3 M2 19.3 2.153e+01 -2.22527</span> -<span class="r-out co"><span class="r-pr">#></span> 7 M2 42.0 4.192e+01 0.07941</span> -<span class="r-out co"><span class="r-pr">#></span> 7 M2 43.1 4.192e+01 1.17941</span> -<span class="r-out co"><span class="r-pr">#></span> 14 M2 49.4 4.557e+01 3.83353</span> -<span class="r-out co"><span class="r-pr">#></span> 14 M2 44.3 4.557e+01 -1.26647</span> -<span class="r-out co"><span class="r-pr">#></span> 28 M2 34.6 3.547e+01 -0.87275</span> -<span class="r-out co"><span class="r-pr">#></span> 28 M2 33.0 3.547e+01 -2.47275</span> -<span class="r-out co"><span class="r-pr">#></span> 60 M2 18.8 1.858e+01 0.21837</span> -<span class="r-out co"><span class="r-pr">#></span> 60 M2 17.6 1.858e+01 -0.98163</span> -<span class="r-out co"><span class="r-pr">#></span> 90 M2 10.6 1.013e+01 0.47130</span> -<span class="r-out co"><span class="r-pr">#></span> 90 M2 10.8 1.013e+01 0.67130</span> -<span class="r-out co"><span class="r-pr">#></span> 120 M2 9.8 5.521e+00 4.27893</span> -<span class="r-out co"><span class="r-pr">#></span> 120 M2 3.3 5.521e+00 -2.22107</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/test_data_from_UBA_2014-1.png b/docs/dev/reference/test_data_from_UBA_2014-1.png Binary files differdeleted file mode 100644 index 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mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" 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class="va">test_data_from_UBA_2014</span></span></code></pre></div> - </div> - - <div id="format"> - <h2>Format</h2> - <p>A list containing three datasets as an R6 class defined by <code><a href="mkinds.html">mkinds</a></code>. - Each dataset has, among others, the following components</p><dl><dt><code>title</code></dt> -<dd><p>The name of the dataset, e.g. <code>UBA_2014_WS_river</code></p></dd> - - <dt><code>data</code></dt> -<dd><p>A data frame with the data in the form expected by <code><a href="mkinfit.html">mkinfit</a></code></p></dd> - - -</dl></div> - <div id="source"> - <h2>Source</h2> - <p>Ranke (2014) Prüfung und Validierung von Modellierungssoftware als Alternative - zu ModelMaker 4.0, Umweltbundesamt Projektnummer 27452</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span> <span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span> <span class="co"># This is a level P-II evaluation of the dataset according to the FOCUS kinetics</span></span></span> -<span class="r-in"><span> <span class="co"># guidance. Due to the strong correlation of the parameter estimates, the</span></span></span> -<span class="r-in"><span> <span class="co"># covariance matrix is not returned. Note that level P-II evaluations are</span></span></span> -<span class="r-in"><span> <span class="co"># generally considered deprecated due to the frequent occurrence of such</span></span></span> -<span class="r-in"><span> <span class="co"># large parameter correlations, among other reasons (e.g. the adequacy of the</span></span></span> -<span class="r-in"><span> <span class="co"># model).</span></span></span> -<span class="r-in"><span> <span class="va">m_ws</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent_w <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"parent_s"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> parent_s <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"parent_w"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span> <span class="va">f_river</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_ws</span>, <span class="va">test_data_from_UBA_2014</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="test_data_from_UBA_2014-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Could not calculate correlation; no covariance matrix</span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_w_0 95.91998118 NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_w 0.41145375 NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_s 0.04663944 NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_w_to_parent_s 0.12467894 NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_s_to_parent_w 0.50000000 NA NA NA NA NA</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.13612618 NA NA NA NA NA</span> -<span class="r-in"><span> <span class="fu"><a href="mkinerrmin.html">mkinerrmin</a></span><span class="op">(</span><span class="va">f_river</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 0.1090929 5 6</span> -<span class="r-out co"><span class="r-pr">#></span> parent_w 0.0817436 3 3</span> -<span class="r-out co"><span class="r-pr">#></span> parent_s 0.1619965 2 3</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="co"># This is the evaluation used for the validation of software packages</span></span></span> -<span class="r-in"><span> <span class="co"># in the expertise from 2014</span></span></span> -<span class="r-in"><span> <span class="va">m_soil</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span>parent <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"M1"</span>, <span class="st">"M2"</span><span class="op">)</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M1 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M3"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M2 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="st">"M3"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> M3 <span class="op">=</span> <span class="fu"><a href="mkinmod.html">mkinsub</a></span><span class="op">(</span><span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span> <span class="va">f_soil</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">m_soil</span>, <span class="va">test_data_from_UBA_2014</span><span class="op">[[</span><span class="fl">3</span><span class="op">]</span><span class="op">]</span><span class="op">$</span><span class="va">data</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-wrn co"><span class="r-pr">#></span> <span class="warning">Warning: </span>Observations with value of zero were removed from the data</span> -<span class="r-in"><span> <span class="fu"><a href="plot.mkinfit.html">plot_sep</a></span><span class="op">(</span><span class="va">f_soil</span>, lpos <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"topright"</span>, <span class="st">"topright"</span>, <span class="st">"topright"</span>, <span class="st">"bottomright"</span><span class="op">)</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="test_data_from_UBA_2014-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">f_soil</span><span class="op">)</span><span class="op">$</span><span class="va">bpar</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 76.55425650 0.859186399 89.1008710 1.113861e-26 74.755959418</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.12081956 0.004601918 26.2541722 1.077359e-16 0.111561575</span> -<span class="r-out co"><span class="r-pr">#></span> k_M1 0.84258615 0.806160102 1.0451846 1.545268e-01 0.113779609</span> -<span class="r-out co"><span class="r-pr">#></span> k_M2 0.04210880 0.017083034 2.4649483 1.170188e-02 0.018013857</span> -<span class="r-out co"><span class="r-pr">#></span> k_M3 0.01122918 0.007245856 1.5497385 6.885052e-02 0.002909431</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 0.32240200 0.240783943 1.3389680 9.819076e-02 NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 0.16099855 0.033691952 4.7785464 6.531136e-05 NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M3 0.27921507 0.269423780 1.0363416 1.565267e-01 0.022978205</span> -<span class="r-out co"><span class="r-pr">#></span> f_M2_to_M3 0.55641252 0.595119966 0.9349586 1.807707e-01 0.008002509</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.14005399 0.149696423 7.6157731 1.727024e-07 0.826735778</span> -<span class="r-out co"><span class="r-pr">#></span> Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 78.35255358</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.13084582</span> -<span class="r-out co"><span class="r-pr">#></span> k_M1 6.23970702</span> -<span class="r-out co"><span class="r-pr">#></span> k_M2 0.09843260</span> -<span class="r-out co"><span class="r-pr">#></span> k_M3 0.04333992</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M1 NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_M2 NA</span> -<span class="r-out co"><span class="r-pr">#></span> f_M1_to_M3 0.86450775</span> -<span class="r-out co"><span class="r-pr">#></span> f_M2_to_M3 0.99489895</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 1.45337221</span> -<span class="r-in"><span> <span class="fu"><a href="mkinerrmin.html">mkinerrmin</a></span><span class="op">(</span><span class="va">f_soil</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> err.min n.optim df</span> -<span class="r-out co"><span class="r-pr">#></span> All data 0.09649963 9 20</span> -<span class="r-out co"><span class="r-pr">#></span> parent 0.04721283 2 6</span> -<span class="r-out co"><span class="r-pr">#></span> M1 0.26551208 2 5</span> -<span class="r-out co"><span class="r-pr">#></span> M2 0.20327575 2 5</span> -<span class="r-out co"><span class="r-pr">#></span> M3 0.05196550 3 4</span> -<span class="r-in"><span> <span class="co"># }</span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/tex_listing.html b/docs/dev/reference/tex_listing.html deleted file mode 100644 index 03bd83f2..00000000 --- a/docs/dev/reference/tex_listing.html +++ /dev/null @@ -1,143 +0,0 @@ -<!DOCTYPE html> 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output of a summary function in tex listing environment</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/tex_listing.R" class="external-link"><code>R/tex_listing.R</code></a></small> - <div class="hidden name"><code>tex_listing.Rd</code></div> - </div> - - <div class="ref-description"> - <p>This function can be used in a R markdown code chunk with the chunk -option <code>results = "asis"</code>.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">tex_listing</span><span class="op">(</span><span class="va">object</span>, caption <span class="op">=</span> <span class="cn">NULL</span>, label <span class="op">=</span> <span class="cn">NULL</span>, clearpage <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>The object for which the summary is to be listed</p></dd> - - -<dt>caption</dt> -<dd><p>An optional caption</p></dd> - - -<dt>label</dt> -<dd><p>An optional label</p></dd> - - -<dt>clearpage</dt> -<dd><p>Should a new page be started after the listing?</p></dd> - -</dl></div> - - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.6.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/tffm0.html b/docs/dev/reference/tffm0.html deleted file mode 100644 index 8988b5a2..00000000 --- a/docs/dev/reference/tffm0.html +++ /dev/null @@ -1,158 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta 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Therefore this transformation was used originally in mkin. It -was later replaced by the ilr transformation because the ilr transformed -fractions can assumed to follow normal distribution. As the ilr -transformation is not available in RxODE and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in nlmixr_model. 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Therefore this transformation was used originally in mkin. It -was later replaced by the <a href="ilr.html">ilr</a> transformation because the ilr transformed -fractions can assumed to follow normal distribution. As the ilr -transformation is not available in <a href="https://nlmixrdevelopment.github.io/RxODE/reference/RxODE.html" class="external-link">RxODE</a> and can therefore not be used in -the nlmixr modelling language, this transformation is currently used for -translating mkin models with formation fractions to more than one target -compartment for fitting with nlmixr in <a href="nlmixr.mmkin.html">nlmixr_model</a>. However, -this implementation cannot be used there, as it is not accessible -from RxODE.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="fu">tffm0</span><span class="op">(</span><span class="va">ff</span><span class="op">)</span> - -<span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_trans</span><span class="op">)</span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>ff</dt> -<dd><p>Vector of untransformed formation fractions. The sum -must be smaller or equal to one</p></dd> -<dt>ff_trans</dt> -<dd><p>Vector of transformed formation fractions that can be -restricted to the interval from 0 to 1</p></dd> -</dl></div> - <div id="value"> - <h2>Value</h2> - <p>A vector of the transformed formation fractions -A vector of backtransformed formation fractions for natural use in degradation models</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span class="va">ff_example</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span></span> -<span class="r-in"> <span class="fl">0.10983681</span>, <span class="fl">0.09035905</span>, <span class="fl">0.08399383</span></span> -<span class="r-in"><span class="op">)</span></span> -<span class="r-in"><span class="va">ff_example_trans</span> <span class="op"><-</span> <span class="fu">tffm0</span><span class="op">(</span><span class="va">ff_example</span><span class="op">)</span></span> -<span class="r-in"><span class="fu">invtffm0</span><span class="op">(</span><span class="va">ff_example_trans</span><span class="op">)</span></span> -<span class="r-out co"><span class="r-pr">#></span> [1] 0.10983681 0.09035905 0.08399383</span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.2.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/transform_odeparms.html b/docs/dev/reference/transform_odeparms.html deleted file mode 100644 index 4cb2e575..00000000 --- a/docs/dev/reference/transform_odeparms.html +++ /dev/null @@ -1,336 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Functions to transform and backtransform kinetic parameters for fitting — transform_odeparms"><meta property="og:description" content="The transformations are intended to map parameters that should only take on -restricted values to the full scale of real numbers. For kinetic rate -constants and other parameters that can only take on positive values, a -simple log transformation is used. For compositional parameters, such as the -formations fractions that should always sum up to 1 and can not be negative, -the ilr transformation is used."><meta name="robots" content="noindex"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]> -<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> -<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> -<![endif]--></head><body data-spy="scroll" data-target="#toc"> - - - <div class="container template-reference-topic"> - <header><div class="navbar navbar-default navbar-fixed-top" role="navigation"> - <div class="container"> - <div class="navbar-header"> - <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false"> - <span class="sr-only">Toggle navigation</span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - <span class="icon-bar"></span> - </button> - <span class="navbar-brand"> - <a class="navbar-link" href="../index.html">mkin</a> - <span class="version label label-info" data-toggle="tooltip" data-placement="bottom" title="In-development version">1.2.3</span> - </span> - </div> - - <div id="navbar" class="navbar-collapse collapse"> - <ul class="nav navbar-nav"><li> - <a href="../reference/index.html">Reference</a> -</li> -<li class="dropdown"> - <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-bs-toggle="dropdown" aria-expanded="false"> - Articles - - <span class="caret"></span> - </a> - <ul class="dropdown-menu" role="menu"><li> - <a href="../articles/mkin.html">Introduction to mkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with (generalised) nonlinear least squares</li> - <li> - <a href="../articles/FOCUS_D.html">Example evaluation of FOCUS Example Dataset D</a> - </li> - <li> - <a href="../articles/FOCUS_L.html">Example evaluation of FOCUS Laboratory Data L1 to L3</a> - </li> - <li> - <a href="../articles/web_only/FOCUS_Z.html">Example evaluation of FOCUS Example Dataset Z</a> - </li> - <li class="divider"> - <li class="dropdown-header">Example evaluations with hierarchical models (nonlinear mixed-effects models)</li> - <li> - <a href="../articles/prebuilt/2022_dmta_parent.html">Testing hierarchical parent degradation kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_dmta_pathway.html">Testing hierarchical pathway kinetics with residue data on dimethenamid and dimethenamid-P</a> - </li> - <li> - <a href="../articles/prebuilt/2022_cyan_pathway.html">Testing hierarchical pathway kinetics with residue data on cyantraniliprole</a> - </li> - <li> - <a href="../articles/web_only/dimethenamid_2018.html">Comparison of saemix and nlme evaluations of dimethenamid data from 2018</a> - </li> - <li> - <a href="../articles/web_only/multistart.html">Short demo of the multistart method</a> - </li> - <li class="divider"> - <li class="dropdown-header">Performance</li> - <li> - <a href="../articles/web_only/compiled_models.html">Performance benefit by using compiled model definitions in mkin</a> - </li> - <li> - <a href="../articles/web_only/benchmarks.html">Benchmark timings for mkin</a> - </li> - <li> - <a href="../articles/web_only/saem_benchmarks.html">Benchmark timings for saem.mmkin</a> - </li> - <li class="divider"> - <li class="dropdown-header">Miscellaneous</li> - <li> - <a href="../articles/twa.html">Calculation of time weighted average concentrations with mkin</a> - </li> - <li> - <a href="../articles/web_only/NAFTA_examples.html">Example evaluation of NAFTA SOP Attachment examples</a> - </li> - </ul></li> -<li> - <a href="../news/index.html">News</a> -</li> - </ul><ul class="nav navbar-nav navbar-right"><li> - <a href="https://github.com/jranke/mkin/" class="external-link"> - <span class="fab fa-github fa-lg"></span> - - </a> -</li> - </ul></div><!--/.nav-collapse --> - </div><!--/.container --> -</div><!--/.navbar --> - - - - </header><div class="row"> - <div class="col-md-9 contents"> - <div class="page-header"> - <h1>Functions to transform and backtransform kinetic parameters for fitting</h1> - <small class="dont-index">Source: <a href="https://github.com/jranke/mkin/blob/HEAD/R/transform_odeparms.R" class="external-link"><code>R/transform_odeparms.R</code></a></small> - <div class="hidden name"><code>transform_odeparms.Rd</code></div> - </div> - - <div class="ref-description"> - <p>The transformations are intended to map parameters that should only take on -restricted values to the full scale of real numbers. For kinetic rate -constants and other parameters that can only take on positive values, a -simple log transformation is used. For compositional parameters, such as the -formations fractions that should always sum up to 1 and can not be negative, -the <a href="ilr.html">ilr</a> transformation is used.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">transform_odeparms</span><span class="op">(</span></span> -<span> <span class="va">parms</span>,</span> -<span> <span class="va">mkinmod</span>,</span> -<span> transform_rates <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> transform_fractions <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span> -<span></span> -<span><span class="fu">backtransform_odeparms</span><span class="op">(</span></span> -<span> <span class="va">transparms</span>,</span> -<span> <span class="va">mkinmod</span>,</span> -<span> transform_rates <span class="op">=</span> <span class="cn">TRUE</span>,</span> -<span> transform_fractions <span class="op">=</span> <span class="cn">TRUE</span></span> -<span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>parms</dt> -<dd><p>Parameters of kinetic models as used in the differential -equations.</p></dd> - - -<dt>mkinmod</dt> -<dd><p>The kinetic model of class <a href="mkinmod.html">mkinmod</a>, containing -the names of the model variables that are needed for grouping the -formation fractions before <a href="ilr.html">ilr</a> transformation, the parameter -names and the information if the pathway to sink is included in the model.</p></dd> - - -<dt>transform_rates</dt> -<dd><p>Boolean specifying if kinetic rate constants should -be transformed in the model specification used in the fitting for better -compliance with the assumption of normal distribution of the estimator. If -TRUE, also alpha and beta parameters of the FOMC model are -log-transformed, as well as k1 and k2 rate constants for the DFOP and HS -models and the break point tb of the HS model.</p></dd> - - -<dt>transform_fractions</dt> -<dd><p>Boolean specifying if formation fractions -constants should be transformed in the model specification used in the -fitting for better compliance with the assumption of normal distribution -of the estimator. The default (TRUE) is to do transformations. -The g parameter of the DFOP model is also seen as a fraction. -If a single fraction is transformed (g parameter of DFOP or only a single -target variable e.g. a single metabolite plus a pathway to sink), a -logistic transformation is used <code><a href="https://rdrr.io/r/stats/Logistic.html" class="external-link">stats::qlogis()</a></code>. In other cases, i.e. if -two or more formation fractions need to be transformed whose sum cannot -exceed one, the <a href="ilr.html">ilr</a> transformation is used.</p></dd> - - -<dt>transparms</dt> -<dd><p>Transformed parameters of kinetic models as used in the -fitting procedure.</p></dd> - -</dl></div> - <div id="value"> - <h2>Value</h2> - - -<p>A vector of transformed or backtransformed parameters</p> - </div> - <div id="details"> - <h2>Details</h2> - <p>The transformation of sets of formation fractions is fragile, as it supposes -the same ordering of the components in forward and backward transformation. -This is no problem for the internal use in <a href="mkinfit.html">mkinfit</a>.</p> - </div> - <div id="author"> - <h2>Author</h2> - <p>Johannes Ranke</p> - </div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>, use_of_ff <span class="op">=</span> <span class="st">"min"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># Fit the model to the FOCUS example dataset D using defaults</span></span></span> -<span class="r-in"><span><span class="va">FOCUS_D</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span> <span class="co"># remove zero values to avoid warning</span></span></span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="co"># Transformed and backtransformed parameters</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.60 1.5702 96.40 102.79</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent_sink -3.04 0.0763 -3.19 -2.88</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent_m1 -2.98 0.0403 -3.06 -2.90</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1_sink -5.25 0.1332 -5.52 -4.98</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.13 0.3585 2.40 3.85</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 102.7931</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04103 0.0560</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04678 0.0551</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># Compare to the version without transforming rate parameters (does not work</span></span></span> -<span class="r-in"><span><span class="co"># with analytical solution, we get NA values for m1 in predictions)</span></span></span> -<span class="r-in"><span><span class="va">fit.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO</span>, <span class="va">FOCUS_D</span>, transform_rates <span class="op">=</span> <span class="cn">FALSE</span>,</span></span> -<span class="r-in"><span> solution_type <span class="op">=</span> <span class="st">"deSolve"</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit.2.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.2.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 96.40384 1.03e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 0.04049 5.54e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 0.04661 5.49e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 0.00384 6.69e-03</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 2.39609 3.85e+00</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.2.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40384 1.03e+02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_sink 0.04792 0.00365 13.11 6.13e-15 0.04049 5.54e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent_m1 0.05078 0.00205 24.80 3.27e-23 0.04661 5.49e-02</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1_sink 0.00526 0.00070 7.51 6.16e-09 0.00384 6.69e-03</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.85e+00</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">initials</span> <span class="op"><-</span> <span class="va">fit</span><span class="op">$</span><span class="va">start</span><span class="op">$</span><span class="va">value</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">initials</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">start</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">transformed</span> <span class="op"><-</span> <span class="va">fit</span><span class="op">$</span><span class="va">start_transformed</span><span class="op">$</span><span class="va">value</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="va">transformed</span><span class="op">)</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/colnames.html" class="external-link">rownames</a></span><span class="op">(</span><span class="va">fit</span><span class="op">$</span><span class="va">start_transformed</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">transform_odeparms</span><span class="op">(</span><span class="va">initials</span>, <span class="va">SFO_SFO</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 log_k_parent_sink log_k_parent_m1 log_k_m1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 100.750000 -2.302585 -2.301586 -2.300587 </span> -<span class="r-in"><span><span class="fu">backtransform_odeparms</span><span class="op">(</span><span class="va">transformed</span>, <span class="va">SFO_SFO</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent_sink k_parent_m1 k_m1_sink </span> -<span class="r-out co"><span class="r-pr">#></span> 100.7500 0.1000 0.1001 0.1002 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="co"># The case of formation fractions (this is now the default)</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">fit.ff</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit.ff.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.ff</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.5985 1.5702 96.404 102.79</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.3157 0.0409 -2.399 -2.23</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -5.2475 0.1332 -5.518 -4.98</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_qlogis 0.0579 0.0893 -0.124 0.24</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.1255 0.3585 2.396 3.85</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 99.59848 1.57022 63.43 2.30e-36 96.40383 102.7931</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.09870 0.00403 24.47 4.96e-23 0.09082 0.1073</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.00526 0.00070 7.51 6.16e-09 0.00401 0.0069</span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 0.51448 0.02230 23.07 3.10e-22 0.46912 0.5596</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 3.12550 0.35852 8.72 2.24e-10 2.39609 3.8549</span> -<span class="r-in"><span><span class="va">initials</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"f_parent_to_m1"</span> <span class="op">=</span> <span class="fl">0.5</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">transformed</span> <span class="op"><-</span> <span class="fu">transform_odeparms</span><span class="op">(</span><span class="va">initials</span>, <span class="va">SFO_SFO.ff</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu">backtransform_odeparms</span><span class="op">(</span><span class="va">transformed</span>, <span class="va">SFO_SFO.ff</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> f_parent_to_m1 </span> -<span class="r-out co"><span class="r-pr">#></span> 0.5 </span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="co"># And without sink</span></span></span> -<span class="r-in"><span><span class="va">SFO_SFO.ff.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinmod.html">mkinmod</a></span><span class="op">(</span></span></span> -<span class="r-in"><span> parent <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span>, to <span class="op">=</span> <span class="st">"m1"</span>, sink <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> m1 <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/list.html" class="external-link">list</a></span><span class="op">(</span>type <span class="op">=</span> <span class="st">"SFO"</span><span class="op">)</span>,</span></span> -<span class="r-in"><span> use_of_ff <span class="op">=</span> <span class="st">"max"</span><span class="op">)</span></span></span> -<span class="r-msg co"><span class="r-pr">#></span> Temporary DLL for differentials generated and loaded</span> -<span class="r-in"><span></span></span> -<span class="r-in"><span></span></span> -<span class="r-in"><span><span class="va">fit.ff.2</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="va">SFO_SFO.ff.2</span>, <span class="va">FOCUS_D</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="va">fit.ff.2.s</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/pkg/saemix/man/summary-methods.html" class="external-link">summary</a></span><span class="op">(</span><span class="va">fit.ff.2</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.2.s</span><span class="op">$</span><span class="va">par</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate Std. Error Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 84.79 3.012 78.67 90.91</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_parent -2.76 0.082 -2.92 -2.59</span> -<span class="r-out co"><span class="r-pr">#></span> log_k_m1 -4.21 0.123 -4.46 -3.96</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 8.22 0.943 6.31 10.14</span> -<span class="r-in"><span><span class="fu"><a href="https://rdrr.io/r/base/print.html" class="external-link">print</a></span><span class="op">(</span><span class="va">fit.ff.2.s</span><span class="op">$</span><span class="va">bpar</span>, <span class="fl">3</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> Estimate se_notrans t value Pr(>t) Lower Upper</span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 84.7916 3.01203 28.15 1.92e-25 78.6704 90.913</span> -<span class="r-out co"><span class="r-pr">#></span> k_parent 0.0635 0.00521 12.19 2.91e-14 0.0538 0.075</span> -<span class="r-out co"><span class="r-pr">#></span> k_m1 0.0148 0.00182 8.13 8.81e-10 0.0115 0.019</span> -<span class="r-out co"><span class="r-pr">#></span> sigma 8.2229 0.94323 8.72 1.73e-10 6.3060 10.140</span> -<span class="r-in"><span><span class="co"># }</span></span></span> -<span class="r-in"><span></span></span> -</code></pre></div> - </div> - </div> - <div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar"> - <nav id="toc" data-toggle="toc" class="sticky-top"><h2 data-toc-skip>Contents</h2> - </nav></div> -</div> - - - <footer><div class="copyright"> - <p></p><p>Developed by Johannes Ranke.</p> -</div> - -<div class="pkgdown"> - <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p> -</div> - - </footer></div> - - - - - - - </body></html> - diff --git a/docs/dev/reference/update.mkinfit-1.png b/docs/dev/reference/update.mkinfit-1.png Binary files differdeleted file mode 100644 index 9278aefd..00000000 --- a/docs/dev/reference/update.mkinfit-1.png +++ /dev/null diff --git a/docs/dev/reference/update.mkinfit-2.png b/docs/dev/reference/update.mkinfit-2.png Binary files differdeleted file mode 100644 index f73a6180..00000000 --- a/docs/dev/reference/update.mkinfit-2.png +++ /dev/null diff --git a/docs/dev/reference/update.mkinfit.html b/docs/dev/reference/update.mkinfit.html deleted file mode 100644 index 90aa0edb..00000000 --- a/docs/dev/reference/update.mkinfit.html +++ /dev/null @@ -1,181 +0,0 @@ -<!DOCTYPE html> -<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1.0"><title>Update an mkinfit model with different arguments — update.mkinfit • mkin</title><!-- jquery --><script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script><!-- Bootstrap --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous"><script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script><!-- bootstrap-toc --><link rel="stylesheet" href="../bootstrap-toc.css"><script src="../bootstrap-toc.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- pkgdown --><link href="../pkgdown.css" rel="stylesheet"><script src="../pkgdown.js"></script><meta property="og:title" content="Update an mkinfit model with different arguments — update.mkinfit"><meta property="og:description" content="This function will return an updated mkinfit object. 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The fitted degradation -model parameters from the old fit are used as starting values for the -updated fit. Values specified as 'parms.ini' and/or 'state.ini' will -override these starting values.</p> - </div> - - <div id="ref-usage"> - <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="co"># S3 method for mkinfit</span></span> -<span><span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">object</span>, <span class="va">...</span>, evaluate <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></code></pre></div> - </div> - - <div id="arguments"> - <h2>Arguments</h2> - <dl><dt>object</dt> -<dd><p>An mkinfit object to be updated</p></dd> - - -<dt>...</dt> -<dd><p>Arguments to <code><a href="mkinfit.html">mkinfit</a></code> that should replace -the arguments from the original call. Arguments set to NULL will -remove arguments given in the original call</p></dd> - - -<dt>evaluate</dt> -<dd><p>Should the call be evaluated or returned as a call</p></dd> - -</dl></div> - - <div id="ref-examples"> - <h2>Examples</h2> - <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co"># \dontrun{</span></span></span> -<span class="r-in"><span><span class="va">fit</span> <span class="op"><-</span> <span class="fu"><a href="mkinfit.html">mkinfit</a></span><span class="op">(</span><span class="st">"SFO"</span>, <span class="fu"><a href="https://rdrr.io/r/base/subset.html" class="external-link">subset</a></span><span class="op">(</span><span class="va">FOCUS_2006_D</span>, <span class="va">value</span> <span class="op">!=</span> <span class="fl">0</span><span class="op">)</span>, quiet <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma </span> -<span class="r-out co"><span class="r-pr">#></span> 99.44423885 0.09793574 3.39632469 </span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_err</a></span><span class="op">(</span><span class="va">fit</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="update.mkinfit-1.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="va">fit_2</span> <span class="op"><-</span> <span class="fu"><a href="https://rdrr.io/r/stats/update.html" class="external-link">update</a></span><span class="op">(</span><span class="va">fit</span>, error_model <span class="op">=</span> <span class="st">"tc"</span><span class="op">)</span></span></span> -<span class="r-in"><span><span class="fu"><a href="parms.html">parms</a></span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span></span> -<span class="r-out co"><span class="r-pr">#></span> parent_0 k_parent sigma_low rsd_high </span> -<span class="r-out co"><span class="r-pr">#></span> 1.008549e+02 1.005665e-01 3.752222e-03 6.763434e-02 </span> -<span class="r-in"><span><span class="fu"><a href="plot.mkinfit.html">plot_err</a></span><span class="op">(</span><span class="va">fit_2</span><span class="op">)</span></span></span> -<span class="r-plt img"><img src="update.mkinfit-2.png" alt="" width="700" height="433"></span> -<span class="r-in"><span><span class="co"># }</span></span></span> -</code></pre></div> - 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