diff options
Diffstat (limited to 'man/saem.Rd')
| -rw-r--r-- | man/saem.Rd | 19 |
1 files changed, 17 insertions, 2 deletions
diff --git a/man/saem.Rd b/man/saem.Rd index d5a8f17e..45f74e44 100644 --- a/man/saem.Rd +++ b/man/saem.Rd @@ -14,9 +14,12 @@ saem(object, ...) object, transformations = c("mkin", "saemix"), degparms_start = numeric(), + test_log_parms = FALSE, + conf.level = 0.6, solution_type = "auto", control = list(displayProgress = FALSE, print = FALSE, save = FALSE, save.graphs = FALSE), + fail_with_errors = TRUE, verbose = FALSE, quiet = FALSE, ... @@ -29,6 +32,7 @@ saemix_model( solution_type = "auto", transformations = c("mkin", "saemix"), degparms_start = numeric(), + test_log_parms = FALSE, verbose = FALSE, ... ) @@ -50,11 +54,22 @@ SFO or DFOP is used for the parent and there is either no metabolite or one.} \item{degparms_start}{Parameter values given as a named numeric vector will be used to override the starting values obtained from the 'mmkin' object.} +\item{test_log_parms}{If TRUE, an attempt is made to use more robust starting +values for population parameters fitted as log parameters in mkin (like +rate constants) by only considering rate constants that pass the t-test +when calculating mean degradation parameters using \link{mean_degparms}.} + +\item{conf.level}{Possibility to adjust the required confidence level +for parameter that are tested if requested by 'test_log_parms'.} + \item{solution_type}{Possibility to specify the solution type in case the automatic choice is not desired} \item{control}{Passed to \link[saemix:saemix]{saemix::saemix}} +\item{fail_with_errors}{Should a failure to compute standard errors +from the inverse of the Fisher Information Matrix be a failure?} + \item{verbose}{Should we print information about created objects of type \link[saemix:SaemixModel-class]{saemix::SaemixModel} and \link[saemix:SaemixData-class]{saemix::SaemixData}?} @@ -104,7 +119,7 @@ f_saem_dfop <- saem(f_mmkin_parent["DFOP", ]) # The returned saem.mmkin object contains an SaemixObject, therefore we can use # functions from saemix library(saemix) -compare.saemix(list(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so)) +compare.saemix(f_saem_sfo$so, f_saem_fomc$so, f_saem_dfop$so) plot(f_saem_fomc$so, plot.type = "convergence") plot(f_saem_fomc$so, plot.type = "individual.fit") plot(f_saem_fomc$so, plot.type = "npde") @@ -112,7 +127,7 @@ plot(f_saem_fomc$so, plot.type = "vpc") f_mmkin_parent_tc <- update(f_mmkin_parent, error_model = "tc") f_saem_fomc_tc <- saem(f_mmkin_parent_tc["FOMC", ]) -compare.saemix(list(f_saem_fomc$so, f_saem_fomc_tc$so)) +compare.saemix(f_saem_fomc$so, f_saem_fomc_tc$so) sfo_sfo <- mkinmod(parent = mkinsub("SFO", "A1"), A1 = mkinsub("SFO")) |