diff options
Diffstat (limited to 'man/synthetic_data_for_UBA.Rd')
| -rw-r--r-- | man/synthetic_data_for_UBA.Rd | 5 |
1 files changed, 4 insertions, 1 deletions
diff --git a/man/synthetic_data_for_UBA.Rd b/man/synthetic_data_for_UBA.Rd index a9df9767..f9d3c77b 100644 --- a/man/synthetic_data_for_UBA.Rd +++ b/man/synthetic_data_for_UBA.Rd @@ -13,7 +13,10 @@ Variance component 'b' is also based on a normal distribution, but with a standard deviation of 7.
Variance component 'c' is based on the error model from Rocke and Lorenzato (1995), with the
minimum standard deviation (for small y values) of 0.5, and a proportionality constant of 0.07
- for the increase of the standard deviation with y.
+ for the increase of the standard deviation with y. Note that this is a simplified version
+ of the error model proposed by Rocke and Lorenzato (1995), as in their model the error of the
+ measured values approximates lognormal distribution for high values, whereas we are using
+ normally distributed error components all along.
Initial concentrations for metabolites and all values where adding the variance component resulted
in a value below the assumed limit of detection of 0.1 were set to \code{NA}.
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