From 9b5f45d5f45722875adada2afc554cec8308a761 Mon Sep 17 00:00:00 2001 From: jranke Date: Mon, 21 Oct 2013 09:46:27 +0000 Subject: - Simplified implementation of mkinerrmin (see ChangeLog) - Improve ChangeLog and add comment to source code - Simple test of the new mkinerrmin implementation in test.R - Added some summaries for documenting the changes in mkinerrmin git-svn-id: svn+ssh://svn.r-forge.r-project.org/svnroot/kinfit/pkg/mkin@120 edb9625f-4e0d-4859-8d74-9fd3b1da38cb --- ChangeLog | 12 ++++++++++-- 1 file changed, 10 insertions(+), 2 deletions(-) (limited to 'ChangeLog') diff --git a/ChangeLog b/ChangeLog index a57894d3..422deb2c 100644 --- a/ChangeLog +++ b/ChangeLog @@ -1,3 +1,9 @@ +2013-10-21 Johannes Ranke for mkin (0.9-22) + + * Get rid of the optimisation step in mkinerrmin - this was unnecessary + Thanks to KinGUII for the inspiration - actually this is equation 6-2 + in FOCUS kinetics p. 91 that I had overlooked originally + 2013-10-17 Johannes Ranke for mkin (0.9-22) * Fix plot.mkinfit as it passed graphical arguments like main to the solver @@ -16,11 +22,13 @@ * Correct the output of the data in the case of manual weighting * Implement IRLS assuming different variances for observed variables - 2013-10-09 Johannes Ranke for version (0.9-22) * Do not use 0 values at time zero for chi2 error level calculations. - This is the way it is done in KinGUII and it makes sense + This is the way it is done in KinGUII and it makes sense. It does + impact the chi2 error levels in the output. Generally they seem to be + lower for metabolites now, presumably because the mean of the observed + values is higher Changes performed in earlier versions are documented in the subversion log files on R-Forge http://www.r-forge.r-project.org/scm/?group_id=615 -- cgit v1.2.1