From 4c6f29fe2a3ece5a85160b891c89ce0f55299c11 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Wed, 23 Jul 2014 08:34:59 +0200 Subject: Parallel metabolite formation with formation fractions in mkinerrmin --- NEWS.md | 4 ++++ 1 file changed, 4 insertions(+) (limited to 'NEWS.md') diff --git a/NEWS.md b/NEWS.md index c10a25b0..9d5129c9 100644 --- a/NEWS.md +++ b/NEWS.md @@ -2,6 +2,8 @@ ## NEW FEATURES +- The number of degrees of freedom is difficult to define in the case of ilr transformation of formation fractions. Now for each source compartment the number of ilr parameters (=number of optimised parameters) is divided by the number of pathways to metabolites (=number of affected data series) which leads to fractional degrees of freedom in some cases. + - The default for the initial value for the first state value is now taken from the mean of the observations at time zero, if available. - The kinetic model can alternatively be specified with a shorthand name for parent only degradation models, e.g. `SFO`, or `DFOP`. @@ -14,6 +16,8 @@ ## BUG FIXES +- In the determination of the degrees of freedom in `mkinerrmin`, formation fractions were accounted for multiple times in the case of parallel formation of metabolites. See the new feature described above for the solution. + - `transform_rates=FALSE` in `mkinfit` now also works for FOMC and HS models. - Initial values for formation fractions were not set in all cases. -- cgit v1.2.1