From 17af45b984d348505527140470c7fff204748ea6 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Fri, 12 Sep 2025 22:16:13 +0200 Subject: Facilitate centering covariates The motivation for this is to obtain confidence intervals for covariate dependent parameters that are valid for a median/mean value of the covariate. Implementation by adding an argument to the 'saem' function, and adapting the relevant functions working with 'saem' objects. Vignettes, the template and tests were updated to use the new functionality. --- README.md | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) (limited to 'README.md') diff --git a/README.md b/README.md index 2d3720ca..a7ecf758 100644 --- a/README.md +++ b/README.md @@ -47,7 +47,7 @@ at the package vignettes The HTML documentation of the latest version released to CRAN is available at [jrwb.de](https://pkgdown.jrwb.de/mkin/) and -[github](https://jranke.github.io/mkin/). +[github](https://jranke.github.io/mkin/). Documentation of the development version is found in the ['dev' subdirectory](https://pkgdown.jrwb.de/mkin/dev/). @@ -238,13 +238,13 @@ saemix for the evaluation of chemical degradation data. Regarding the application of nonlinear mixed-effects models to degradation data, von Götz et al (1999) have already proposed to use this technique in the context of environmental risk assessments of pesticides. However, this work was -apparently not followed up, which is why we had to independently arrive at the +apparently not followed up, which is why we had to independently arrive at the idea and missed to cite this previous work on the topic in our first publications. ## References - - +
Ranke J (2023) Application of nonlinear hierarchical models to the +
Ranke J (2023) Application of nonlinear hierarchical models to the kinetic evaluation of chemical degradation data - Guidance for the use of an R markdown template file. Umweltbundesamt TEXTE 151/2023 @@ -270,7 +270,7 @@ idea and missed to cite this previous work on the topic in our first publication 30 17 doi:10.1186/s12302-018-0145-1
Von Götz N, Nörtersheuser P, Richter O (1999) Population based analysis of pesticide kinetics Chemosphere -- cgit v1.2.1