From e48c1f2ef990a622722e416c8d301430db4f5081 Mon Sep 17 00:00:00 2001 From: Johannes Ranke Date: Wed, 16 Mar 2022 14:42:30 +0100 Subject: Use saemix in help page, typo in vignette --- docs/articles/web_only/dimethenamid_2018.html | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) (limited to 'docs/articles') diff --git a/docs/articles/web_only/dimethenamid_2018.html b/docs/articles/web_only/dimethenamid_2018.html index 0ba9d5a8..09aa5150 100644 --- a/docs/articles/web_only/dimethenamid_2018.html +++ b/docs/articles/web_only/dimethenamid_2018.html @@ -105,7 +105,7 @@

Example evaluations of the dimethenamid data from 2018

Johannes Ranke

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Last change 7 March 2022, built on 07 Mar 2022

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Last change 7 March 2022, built on 16 Mar 2022

Source: vignettes/web_only/dimethenamid_2018.rmd @@ -426,7 +426,7 @@ DFOP tc more iterations 665.88 663.80

Conclusion

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A more detailed analysis of the dimethenamid dataset confirmed that the DFOP model provides the most appropriate description of the decline of the parent compound in these data. On the other hand, closer inspection of the results revealed that the variability of the k2 parameter across the population of soils is ill-defined. This coincides with the observation that this parameter cannot robustly be quantified in some for some of the soils.

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A more detailed analysis of the dimethenamid dataset confirmed that the DFOP model provides the most appropriate description of the decline of the parent compound in these data. On the other hand, closer inspection of the results revealed that the variability of the k2 parameter across the population of soils is ill-defined. This coincides with the observation that this parameter cannot robustly be quantified for some of the soils.

Regarding the regulatory use of these data, it is claimed that an improved characterisation of the mean parameter values across the population is obtained using the nonlinear mixed-effects models presented here. However, attempts to quantify the variability of the slower rate constant of the biphasic decline of dimethenamid indicate that the data are not sufficient to characterise this variability to a satisfactory precision.

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